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دراسات حركية ثرموديناميكية لانزيم الكلوتاثيون الناقل المنقى جزئيا من مصل دم الانسان مع تاثير بعض ادوية علاج السكري

اسم المؤلف: غفران عبد عمران عبد الرضا محمد الخفاجي
اسم المشرف: عودة مزعل ياسر الزاملي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: This study involved (30) Person healthy (15males & 15 femals) the ages were between (20 - 25) years were obtained on samples of students from the university of Babylon / College of Science in Babel province, Iraq has been selected as control group without chronic disease and without smoking.This study attempt isolate GST enzyme from serum human .The partial purification of glutathione - S - Transferase were done using DEAE - Cellulose ,Then purification steps include precipitation by ammonium sulfate 70%, The specific activity was 0.244 U/mg protein and purification degree 1.07 folds and stepwise of Di ethyl amino ethyl - cellulose chromatography and further purified with DEAE - Cellulose column chromatography. The enzyme was apply on DEAE - Cellulose (1.5×30cm) and flow rate 1ml/min and The specific activity was 0.314 U/mg protein with recovery 55.14% and purification degree 1.50 folds.then the glutathione - S - transferase enzyme purified also from serum human by using pre - packed column affinity chromatography by containing glutathione Sepharose 4% and compare specific activity between two separation ways the activity of GST enzyme result from affinity column were more by using ion exchange column and measured of enzyme activity at 340nm by using CDNB as substrate of GST enzyme .The electrophoresis of the partial from human serum from ion - exchange chromatography and affinity chromatography in polyacrylamide gel was found that it was one protein band by using SDS - PAGE analysis by usingenzyme GST result from ion - exchange chromatography 27.7KD and affinity chromatography found (28KD). This study involved also some kinetic studies of GST , maximum activity for GST enzyme was obtained using 22.463mmol/L of 1 - chloro - 2,4 - dinitrobenzene (CDNB)as substrate ,the enzyme showed maximum activityat 35 and optimum pH at 6.8 and time at 12 minutes in incubation at 35 . Using Lineweaver - Burk plot the maximum velocity (Vmax ) and Michaelis constant Km were (11.12mmol/liter) and Vmax (1.254μmol/min) respectively .The thermodynamic constants of activation , were determined by using Arrhenius plot and found to be (35.906kJ. mol - 1, 31.73kJ.mol - 1, - 1.729 kJ.mol - 1.k ,551.40 kJ.mol - 1.k) respectively .Metformin and Dionial inhibition on the GST activity were found that , this lead to drugs effect on enzyme GST.Where showed result that non comparative inhibitor at metformin and showed that comparative inhibitor at dionial .

الاستخلاص بنقطة الغيمة لتقدير الكلور امفينيكول طيفيا في المستحضرات الصيدلانية == CLOUD POINT EXTRACTION FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CHLORAMPHENICOL IN PHARMACEUTICAL PREPARATIONS

اسم المؤلف: ضياء يحيى عزيز الحميدي
اسم المشرف: عباس نور محمد الشريفي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: In this thesis chloramphenicol drug was determined by three methods with spectrophotometric technique.In the first method chloramphenicol was reacted with p - N,NDimethyl - aminobenzaldehyde and form yellow Schiff base product which gave higher absorbance at 436.5 nm. Schiff base reaction occurs between two compounds, one contains amino group and the other contains carbonyl group but chloramphenicol is nitro compound therefore it must convert nitro group in drug to amino group therefore reduction process to nitro group necessary for convert it to amino group.Therefore optimum conditions of reduction process were studied to know exactly the volume of concentrated hydrochloric acid which will give higher absorbance of product. Also amount of zinc, temperature of heating and time from heating during the reduction process were studied. Other optimum conditions of reaction also were studied and Calibration curve constructed and regression equation known (y = 0.0556x + 0.0246), also range of concentration which obeys Beer - Lambert Law was (0.1 - 12)ppm, Molar absorptivity (1.8 * 104 ), Sandell's sensitivity (1.8 * 10 - 2), LOD and LOQ (0.037) and (0.124) respectively. also other studies were performed such as accuracy and precision, Molar ratio method, continues variation method, reaction mechanism, Stability constant of product, Analytical applications and t - test and F - test. The proposed method was successfully in determination of chloramphenicol (CAP) in pharmaceutical preparations with good values of recovery presents (97.6% - 102.5%) and Relative Error E% between ( - 2.351 - 2.562).In the second method, chloramphenicol was reacted with 1,2 - Naphthoquinone - 4 - Sulphonic Acid Sodium Salt in basic medium by condensation reaction and form orange - red product which gave higher absorbance at 489 nm.Optimum conditions of reaction were studied and Calibration curve constructed and regression equation known (y = 0.0577x - 0.0006), also range of concentration which obeys Beer - Lambert Law was (1 - 9)ppm, Molar absorptivity (1.86 * 104), Sandell's sensitive (1.73* 10 - 2), LOD and LOQ (0.068) and (0.207) respectively. Also other studies were performed such accuracy and precision, Molar ratio method ,continues variation method, reaction mechanism, stability constant of product, analytical applications and t - test and F - test. The proposed method was successfully in determination CAP in pharmaceutical preparations with good values of recovery presents (96.149% - 103.307%) and Relative Error E% between ( - 3.851 - 3.307) In the third method, cloud point extraction was applied by extractingthe product used in the second method because there is interaction between the alkaline medium and reagent, this the interaction leads to develop colored reagent and some of radiation absorbed at maximum wavelength of product therefore used cloud point extraction to remove the interference and enhancing sensitivity of method and increasing stability of product.Chloramphenicol was reacted with 1,2 - Naphthoquinone - 4 - Sulphonic Acid Sodium Salt in basic medium by condensation reaction forming orange - red product by using same optimum condition of reaction in the second method then the product was extracted from the solution by using cloud point extraction technique.Optimum conditions of cloud point extraction were studied and Calibration curve was constructed and regression equation known (y = 0.2318x + 0.0639), the range of concentration that obeys Beer - Lambert Law was (0.1 - 6) ppm, Molar absorptivity (7.49 * 104), Sandell's sensitivity (4.31* 10 - 3), LOD and LOQ (0.032) ppm and (0.097)ppm respectively. Also Recovery of solute ( was(99.92), preconcentration factor (fc) (3.33333) and phase volume ratio (Rv) (0.3), also other studies were performed such accuracy and precision, analytical applications and test and F - test. The proposed method was successful in determine chloramphenicol (CAP) in pharmaceutical preparations with good values of recovery percent (96.091% - 101.834%) and Relative Error E% between ( - 3.909 - 1.834).Finally, this thesis presented a proposal for a new way to deal with the data in the analytical methods, which includes the new equations to find a slop and y - intercept of a straight line equation as well as introduced new parameters to determine the best linear correlation between the results, it is average of recovery (Arec), the sum of the absolute values of the relative error (SARE) in concentration computed as well as the average of the absolute values of relative error ( AARE) that gives the best results and more accurate than the usual equation.

البلمرة التكاثفية للبنتااريثريتول مع حامض الفثاليك اللامائي وتحويرة ودراسة خواصة == Condensation Polymerization of Pentaerythritol with Phthalic Anhydride and Modification and Study of its Properties

اسم المؤلف: رواء حفظي زعولي
اسم المشرف: محمد ناظم بهجت | ناظر نجم عبد الله
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: تضمن البحث تحضير الكوبوليمر المحور بخطوتين : الخطوة الاولى ، تتضمن تحضير بوليمرتكاثفي باستخدام بنتا اريتريتول وانهيدرايد الفثالك وانهيدريد الماليئك بواسطة عملية الاسترة .ان الهيكل التركيبي للبوليمر المشترك المحور الذي حصلنا عليه ، كما يلي : وشخص البوليمر المحضر بواسطة مطيافية FTIR وHNMR الخطوة الثانية ، تتضمن تحضير راتنج ذو قوام شرابي باضافة (1مول،1.5مول ،2 مول) مونومير حامض الاكريلك على التوالي الى البوليمر ، لنحصل على تلاثة انواع من الراتنج .تضمن العمل عدد من الفحوصات مثل ، الانتفاخية في الماء والتولوين والايثانول في درجات حرارية مختلفة ، الانتفاخية في محلولي بفر ذوPH مختلف وخواص قوة الشد. تم حساب معاملات الانتفاخية في الماء والتولوين والايثانول،حيث وجد ان محتوى الماء في الهلام المائي يزداد بزيادة زمن الانتفاخية . كذلك تم دراسة تا ثير درجة الحرارة على الانتفاخية في الماء والتولوين والايثانول عند درجات حرارية مختلفة تتراوح مابين 298 - 318 كلفن . تزداد معاملات الانتفاخية بزيادة درجة الحرارة وكذلك فان الكسر الحجمي للراتنج (2 Ф) تقل بزيادة درجة الحرارة .من خلال اختبارات الشد ، لوحظ ان البوليمر المحضرذو سلوك ميكانيكي لين - ضعيف للراتنج المحتوي على الاكريلك اسد. | In this work, a new modified Co - polymer was prepared by condensation polymerization by using phthalic anhydride, pentaerythritol and maleic anhydride through esterification reaction.The structure of modified co - polymer was : Identification of modified polyester resin by FT - IR, 1H - NMRA preparation of pourable syrup resins by the addition of (1, 1.5 and 2 moles) acrylic acid monomer respectively, to the modified polymer, to give three types of resins.Many tests were carried out, i.e., swelling degree in water, toluene and ethanol at different temperatures, and swelling at two different PH. Also the tensile properties of the prepared polymers have been studded.The swelling parameters in water, ethanol and toluene were calculated. The water content, of hydrogels increased with increasing time of swelling. The effect of temperature on the swelling in water, ethanol and toluene at different temperatures ranging from 298 to 318 K was also studied. The water, ethanol and toluene content have been increased with increasing temperature. While the volume fraction of the resins (Ф2) have been decreased with increasing temperatures. From the tensile tests, it was found that the prepared polymer; have soft - weak behavior.

فصل انزيم اللايبوكسيجينيز من مصل الرجال الاصحاء ومعاملة خارجية للانزيم في مرضى الربو == Separation of Lipoxygenase from Sera of Healthy men and in Vitro Treatment of Enzyme in Asthmatic Patients

اسم المؤلف: احمد جياد عباس البرقعاوي
اسم المشرف: عودة مزعل ياسر الزاملي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: دكتوراه
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: This study is concerned with asthma. Sixty seven asthmatic male patients were examined and tested , their age ranged from 10 - 65 years and they previously diagnosed as asthmatic patient under the physician supervision in AL - Hilla center of Allergy and Asthma . They have the disease for more than five years. Forty patients were examined during the period between July2015 to October 2015, and twenty seven patients were examined during period between June to August 2016, also the control group consisted of sixty seven healthy males ranged from 10 - 65 years.In this study asthmatic patients were divided into three groups according to medication , the first group consisted of (17) asthmatic patients taking antihistamines such as loratadine , citrizine and allermine , while the second group included (24) asthmatic patients taking montelukast , and the third group included (26) asthmatic patients who were on different drugs other than antihistamines and montelukast such as steroids and beta agonists .Five milliliters of blood were obtained from each patient, serum collected absolutely free from hemolysis stored at - 20 °C until uses for measurement of the concentrations of Glutathione, Malondialdehyde, Catalase, Histamine, Serotonin, Lipoxygenase - 5, Leukotriene A4 Hydrolase, total Immunoglobulin E and specific immunoglobulin E.The results revealed that the mean of IgE level (measured by ELISA system)in serum of asthmatic group was (368.16 ±1.772 ng/ml) versus the control group (138.9±2.515 ng/ml) with a significant difference,)P < 0.001(. Asthmatic patients and patients treated with pharmacological drugs such as montelukast and antihistamines showed high sensitivity to some food, animals, plant, palm pollen, fungal and mite allergen and they showed different values between patients and control. The study showed that there is no association between the increased sensitization to food, animal, plant and fungal allergens with age of patients.The present study showed the relationship of count blood cells (WBC and RBC) in studied groups. In all studied groups, WBC values higher than control group while the RBC values showed little differences among all studied groups.According to levels of some variables (histamine, serotonin, LOX - 5 and LTA4H) in asthmatic patients, the results showed a higher mean value of serotonin in asthmatic patients (0.023± 0.004 ng /ml) compared with control group (0.002± 0.001 ng/ml, p˂0.001) In addition the value of histamine was observed high in asthmatic patients (8.511± 0.410 ng /ml)while the control group was (2.565 ± 0.140 ng/ ml) with a significant difference of the mean value of histamine between asthmatic patients and control group (p˂0.001). LOX - 5 level in serum of asthmatic patients was higher (11.080 ± 0. 190 ng/ml) than in control group (9.821 ± 0.203 ng/ml, p˂0.001.The data revealed significant high mean value of LTA4H in asthmatic patients (24.148 ± 0 .450 ng/ml) compared with control group (18.912 ± 0.459 ng/ml, p˂0.001).The result showed that histamine level was increased in the group (>40 years) with a mean value (9.67 ± 4.25 ng /ml ) . While LOX - 5 showed high mean value (11.532 ± 1.274) in the group 20 - 40 years . Also LTA4H enzyme showed high mean value (25.54 ± 3.504 ng/ml)in the group 20 - 40 years , while serotonin appeared with high mean value (0.027± 0.015 ng/ml) in the group (< 20 years) with a significant difference between levels of these variables in each age group (p ˂ 0.001)The mean concentration of an antioxidant, Glutathione(GSH), and Malondialdehyde (MDA) in serum of asthmatic patient and control groups. The mean concentration of MDA increased in asthmatic patients (11.317 ± 1.096 μmol/l) more than control group(8.733 ± 3.756 μmol/l)with a significant difference between these groups (p < 0.05). The mean concentration of GSH increased was in the control (5.106 ± 3.197 μmol/l) more than asthmatic patients(3.905 ± 1.638 μmol/l, p < 0.05).According to the results of the present study, the mean activity of catalase(CAT) was higher (1.555±0.982 U/l) in asthmatic patients when compared with control group(1.173 ± 0.502 U/l, p < 0.05).The current study also concerned with the extrection of lipoxygenase from serum of asthmatic patient and healthy men by taking 15 ml serum from ten asthmatic patients men and 15 ml from serum of ten healthy men. And these quantities of serum were precipitated by ammonium sulfate, The best ratio for precipitating serum and extraction of enzyme is 60%. The anion exchange chromatography was used for extraction of the enzyme. The molecular weight of the extracted enzyme was determined by SDS - PAGE . In this procedure one subunit of the extracted LOXs enzyme showed a molecular weight of 35KD for one chain while a recombinant pure human LOX - 5 showed a molecular weight of 38 KD. The current study used NATIVEN technique for purification of the extracted enzyme obtained from ion exchange chromatography.The results revealed the optimum pH and temperature for LOXs activity and they were 8 and 40°C, respectively.The velocity constant and maximum velocity of the extracted Lipoxygenase enzyme was detected by using PHYWE SYSTEME GMBH SYSTEM, this system had the ability to obtain the relationship between conductivity and concentration (an increase in concentration lead to an increase in conductivity).The extracted lipoxygenase enzyme Km was 2.2mM and Vmax= 140mM/min in asthmatic patients and Km was 2.7mM and Vmax= 135mM/min in controls (by applying Michaelis - Menten equation).While the enzyme Km= 5.5mM and Vmax= 238mM/min in asthmatic patients and Km= 5 mM and Vmax= 208 mM/min in controls (by applying Lineweaver - Burk equation).The extracted LOXs from asthmatic patients and controls was treated with montelukast. The Km and Vmax appeared to have low values Km 3.6mM and Vmax 153mM/min and Km 3.7mM and Vmax 147mM/min, respectively. Also the extracted LOXs from asthmatic patients and controls was treated with molsiodomine, showed low values Km 4.4mM and Vmax 182 mM/min and Km 4.3mM and Vmax 166 mM/min, respectively.

دراسة مستويات بعض مضادات الاكسدة غير الانزيمية وعنصري الحديد والنحاس في مصل دم مرض اضطرابات الغدة الدرقية في محافظة ميسان - العراق

اسم المؤلف: مهدي عودة محمد الساعدي
اسم المشرف: ساهرة غريب صياح
الموضوع العام: علوم الكيمياء
السنة: 2013
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: ماجستير
الجامعة: جامعة البصرة - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: the current study was designed to measure some Biochemical function in serum of patients with disorder of the thyroid gland (hyperthyroidism and hypothyroidism ), which can help in the early detection and follow - up of the malfunction of the thyroid gland.Specimens collected from 124 patients with malfunction of the thyroid gland Specimens were classified accord is to the type of disease ( an overactive thyroid gland = 62 , hypothyroidism = 62) and 62 blood samples in were collected from healthy non - infected persons (control group).The study included measuring automatically the levels of thyroid hormones, (FT4, FT3) and (TSH) in the serum using a Mini - VIDAS . The levels of vitamins (E, C) and beta - carotene , and uric acid were measured , also the levels of some trace elements (iron , copper) ,were measured in the serum three above groups.The results showed the following - :  The results of the present study ,the highest percentage of patients with hypothyroidism were indicated that females and the of malfunction of the thyroid gland is occurred at the third and fourth decade of life. The impact of the genetic factor in patients with excessive secretion of the thyroid gland were higher than in patients with deficient secretion of the thyroid gland. A significant increase in the level of the hormone tri - iodothyronin (FT3) and the level of the hormone tetra - iodothyronin (FT4) and a significant decrease in the level of thyroid stimulating hormone (TSH) in patients with excessive thyroid gland secretion compared to the control group. A significant decrease in the level of hormones (FT3), (FT4) and a significant increase in the level of the hormone (TSH) in patients with hypothyroidism compared to the control group.  Generally, there was a significant decrease in the level of vitamins C,E in the sera of patients with malfunction of thyroid compared to the control group. A significant increase in the level of uric acid in patients with excessive thyroid activity and a significant decrease in patients with thyroid failure compared to the control group.  A Significant decrease in the level of beta - carotene in patients with an overactive thyroid , and a significant increase in the level of beta - carotene in patients with hypothyroidism compared to the control group. A Significant decrease in the level of iron in the sera of patients with malfunction compared to the control group. A significant increase in the level of copper in patients with excessive thyroid activity and a significant decrease in patients with thyroid failure compared to the control group.

دراسة التاثيرات الانجابية لبعض العناصر النزرة على العقم عند الرجال في محافظة ذي قار - العراق == Reproductive Effects of Some Trace Elements On Male Infertility, In Thi - Qar Governorate/Iraq

اسم المؤلف: ملاك حريز نعيم الخفاجي
اسم المشرف: ساجد حسن كزار | ايناس صالح جواد
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:

تحضير وتشخيص وتقييم الفعالية البايولوجية لبعض مركبات الفورمازان المشتقة من قواعد شف ومركبات الازو الجديدة ومعقداتها مع الكادميوم الثنائي II == Synthesis , Charactrization and Evaluation Biological Activity of some New Formazan Compounds Derived from Schiff Bases and Azo Compounds and Their Complexes With Cadmium(II)

اسم المؤلف: محمد عبد الحسن شلال
اسم المشرف: حيدر عباس مهدي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: The letter includes the preparation of twenty new derivatives of Formazan compounds that include Schiff bases associated with AZO compounds.The spectrum of spectroscopy (FT.IR) for all compounds, the NMR spectrum, the NMR spectrum of NMR and the CHIS for all compounds and the identification of some of their physical properties such as grade (TPC), and then to prepare four complexes (two of them for morphine and two forformas) as complexes with cadmium ion, to determine optimal conditions for complex formation and then to measure the molecular conductivity of the complex as well as the electronic measurements Wa For magnetic sensitivity. And then studying of biological activity. For some of these vehicles the research has included two main parts : section One : I attended and identified a group of derivatives (Schiff bases) and then were linked through the interaction of the nuts under certain conditions for the preparation of new Formazan compounds containing (Schiff bases - AZO compounds) on the same compound and then attended four complexes of two Schiff bases and two of the Lycandat Formazan The new vehicles have been identified above Section Two : This part of the work was studied by studying the vital effectiveness of some compounds. Schiff bases and Formazan compounds were selected to determine the effect of the active groups of the compound on inhibiting the biological activity of the microorganisms studied in this thesis

تحضير وتشخيص بعض مشتقات قواعد شف والفورمازانات ومعقداتهما واستخدامهما في استخلاص ايون Cr+6 بطريقة استخلاص نقطة الغيمة == Preparation and Characterization of some Schiff base and formazans derivatives and their Complexes and using them in the Extraction of (Cr+6) Ion By Mothed Cloud - Point Extraction

اسم المؤلف: بتول مهدي صالح
اسم المشرف: ساهر عبد الرضا علي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: This study includes the preparation of ten ligands and it′s complexs : Ligand L4 (N - (4 - ((2 - (phenylcarbamothioyl)hydrazono)methyl)phenyl) acetamide) was prepared by the condensation of (4 - acetamido benzaldehyde) with (4 - phenylthiosemi carbazide). Ligand L5 (1, 3 - bis (2 - hydroxy - 3 - methoxy - (E) - benzylideneamino) eurea) was prepared by the condensation of (o - vanillin) with (carbohydrazide). Formazan F1 (1 - benzoyl - 3 - (2 - hydroxyphenyl) - 5 - phenylformazan) is prepared from coupling the diazonium salt with (L1) proportions Molar (1 : 1). Formazan F2 (3 - (2 - hydroxyphenyl) - 1 - nicotinyl - 5 - phenyl formazan) was prepared by coupling the diazonium salt with (L2) proportions Molar (1 : 1).Complexes were prepared for (L3), (F1) and (F2) by interaction with the salts of the elements NiCl2.6H2O, CoCl2.6H2O, CdCl2.6H2O, CrCl3.6H2O. The ligands and it′s complexes were characterized by using Elemental Analysis (C.H.N) Infrared Spectroscopy(FT - IR), Nuclear Magnetic Resonance Spectroscopy (1H - NMR) , Mass Spectra and Molar Electrical Conductivity and the results were identical to what is expected scientifically. The spatial shape of the complexes prepared is (octahedral). (ligand L1 and formazan F1) on distribution ratio values and percentage of extraction, where results showed that percentage values and distribution ratio in this way increase with increasing concentration of (L1 and F1) where he found that the best distribution ratio (D) and percentage (% E) to extract ion(Cr+6) when concentration (L1 & F1) is (5 * 10 - 4 M).

تحضير , تشخيص ودراسة بيولوجية لمشتقات جديدة من 4,3,1 - ثايادايازول ومعقداتها مع بعض ايونات العناصر الانتقالية == Preparation , Characterization and biological study of new derivatives of 1,3 , 4 - Thiadiazole and their complexes with some transitional element ions

اسم المؤلف: نعيم عبد السادة بشير الخفاجي
اسم المشرف: ابراهيم عبود فليفل
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: The present study involves preparation of three new ligands derived from the thiadiazole (2,5 - dihydrazineyl - 1,3,4 - thiadiazol) with 1H - indole - 2,3 - dione (Isatin) by the ratio (1 : 2). the ligands L1 and L2 were synthesized from the reaction between thiadiazole derivative with (Benzophenone) by the ratio (1 : 2). The ligand L3 was prepared from thiadiazole derivative and (3 - aminoacetophenone) by the ratio (1 : 2), the following are the structural formulas of the prepared ligands : Prepared the complexes of the transitional elements ions [Cr+3, Fe+3, Co+2, Ni+2 and Cu+2] with ligands (L1, L2 and L3), where the ligands and their complexes characterization by precision analysis of elements (C.H.N.), Infrared spectrum (FT - IR), proton Nuclear Magnetic Resonance (1H - NMR), Mass spectrometry, measurement magnetic sensitivity and measurement molarconductivity the results were practical exactly matching with the molecular and structural formulas of the proposed compounds. Hyperchem was used to draw ligands and their complexes and to show the distribution of electronic density. The data indicates that the configuration of the complexes {[CrL1Cl3], [FeL1 3] , [CoL1 3]}, {[CrL2 3], [FeL2 3] ,[CoL2Cl3]} {[Cr(L3)2Cl ]Cl, 3)2Cl2] and [Co(L )2Cl2]Cl} are octahedral , while the proposed configuration of the complexes {[NiL Cl2], 1Cl2]}, [NiL2Cl2] [CuL2Cl ]} ,{[NiL Cl2] and [CuL3Cl2 are square planer. A study was conducted testing the biological activity for the prepared ligands and their complexes against two types of bacteria (staphylococcus aureus) and (Escherichia coli) compared to the standard inhibitor (Ciprofloxacin), the obtained results confirmed the biological effectiveness of prepared preparations except for the third ligand higher than standard inhibitor (Cipro) towards the bacteria (Escherichia coli), the following complexes also showed (A5, C5, C4, C3 and C1) biological effectiveness towards the bacteria (Escherichia coli) higher than standard inhibitor (Cipro), while the rest complexes showed less effectiveness than the standard inhibitor (Cipro) ) 4and A 3, A2(A ) except the complexesEscherichia colitowards the bacteria (where don't showed any biological effectiveness. Also the study confirmed that ligands and their complexes did not show any biological activity towards the bacteria (staphylococcus aureus).

استخلاص وتشخيص ودراسة كيموحيوية لبعض الزيوت الاساسية في نبات الرشاد البري في مدينة الناصرية / العراق

اسم المؤلف: مريم ماجد كاظم الحسيناوي
اسم المشرف: حسام محمد كريدي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: ذي قار
الصفحات الاولى:

تحضير وتشخيص وتقيم الفعالية البيولوجية لبعض مركبات الفورمازان المشتقة من قواعد شف الجديدة ومعقداتها مع بعض العناصر الانتقالية == Synthesis, characterization and biological evaluation of some new Formazan compounds derived from Schiff Bases and their complexes with some transition Metals.

اسم المؤلف: اعراف محمود داود
اسم المشرف: حيدر عباس مهدي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: This thesis contains three chapters represents, the first chapter introduction and interested in studying the chemistry of schiff base and derivatives of formazan, their complexes in terms of their characteristics, importance and synthesis.The second chapter is interested in describing the chemicals and procedures used in the synthesis of the required compounds, and the study of physical measurements, synthesis methods of compounds and evaluation as well as the biological activity.In this research, four new derivatives of formazan (L3, L4, L5 - 4d), which synthesized from the reaction of Diazonium salt amine with suitable Schiff base (L1, L2 - 2d). The Schiff base can product of different primary amines with several aromatic aldehyde and synthesized both of the (Schiff bases, formazans) suitable complexes.The third chapter Results and Discussion, identified synthesized formazan derivatives as well as Schiff bases prefix and its complexes by appropriate spectral methods including of infrared spectroscopy (FT - IR) for all compounds, Nuclear Magnetic Resonance spectrum (1H - NMR) for all compounds Microanalysis (CHNS) for the majority of compounds as well as Mass spectra. For all complexes were recording certain physical properties, such as melting point (m.p.). Monitoring progress of the chemical reaction by using thin chromatography layer (TLC). We synthesis eight complexes (three from Schiff bases and five from formazan derivatives) were complexes with ions (Co, Ni, Cd), then measuring the molar conductivity of complexes. Then study the biological effectiveness for some compounds have been chosen complexes Schiff bases, as well as formazan complexes to determine the effect of active groups in these compounds to evaluate the efficiency ofXIthe compounds against different type of bacteria.The research also includes a test of biological effectiveness of the prepared ligands and their metallic complexes, where we study response inhibitory to the three types of bacteria, a gram positive type of bacteria (Staphylococcus aureuse) and gram negative type of the bacteria (Escherichia Coli and salmonella species) and compared with the standard inhibitor (Cipro).The biological effectiveness swohs positive results as it was noted The ligand L1, L2, L3, L4, L5 and Schiff base 4d Showed lower efficiency than the standard inhibitor trend three types of bacteria. The prepared complexes from ligands appeared high effective than the effectiveness of the ligands itself The formazan (L3, L4, L5 dna 2d) appeared high effective than the effectiveness of the prepared Schiff base

تخليق وتشخيص بعض المركبات الاحادية والثنائية للكاما لاكتام والثايزوليدينون == SYNTHESIS AND CHARACTERIZATION OF SOME MONO AND BIS ? - LACTAMS AND THIAZOLIDINONES COMPOUNDS

اسم المؤلف: اصالة سلام جبر
اسم المشرف: محمود شاكر مكطوف التميمي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء العضوية
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: This study is concerned with the synthesis and characterization of mono, bis γ - lactams 3(a - h) and mono, bis Thiazolidinone 4(a - i). The structures of the prepared compounds are confirmed by the spectral data include FT - IR spectroscopy , 1H - NMR spectroscopy , 13C - NMR spectroscopy, Mass spectroscopy.Mono and bis γ - Lactams are prepared by reacting Phenyl succinic anhydride with the appropriate Schiff base , in dry chloroform. The obtained mono and bis γ - lactams 3(a - g) is in moderate yields (51 - 75%).The FT - IR spectra showed an absorption bands at (1636 - 1692 cm - 1) attributed to amide carbonyl group ( - N - C=O), and at (1699 - 1733 cm - 1) carboxylic group which attributed (COOH) . The 1H - NMR spectra of compounds 3(a - g),show signals of the aliphatic protons at rang (3.356 - 4.02) ppm and signals for aromatic protons at rang (7.202 - 8.218) ppm. The 13C - NMR spectra of compounds 3(a - e), show signal at rang (171.30 - 178.58) ppm which related amide carbon ( - N - C=O), and at rang (178.32 - 182.16) ppm carboxylic carbon (COOH).Mono and bis Thiazolidinones are prepared by the reaction of thioglycolic acid with Schiff base, in dry benzene. The produced Thiazolidinones 4(a - f) is in moderate yields (55 - 78%).The FT - IR spectra showed an absorption band at (1654 - 1691 cm - 1) attributed to carbonyl group which is related to ( - N - C=O). The 1H - NMR spectra show signals of the aliphatic protons at rang (4.2 - 7.1) ppm and signals for aromatic protons at rang (7.352 - 8.015) ppm. The 13C - NMR spectra show signals at rang (172.32 - 179.52) ppm which is related to amide carbonyl group ( - N - C=O).

دراسة مستويات مصل الهوموسيستين وعلاقته مع بعض انزيمات القلب في المرضى الذين يعانون من احتشاء عضلة القلب في محافظة ذي قار - العراق == Study of Serum Homocysteine levels and Its Correlation with Some Cardiac Enzymes in Patients with Myocardial Infarction In Thi - Qar Province/Iraq

اسم المؤلف: اديان سعد حمزة
اسم المشرف: محمد عجة عودة
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: Myocardial infarction (MI) or acute myocardial infarction (AMI) is the medical term for an event commonly known as heart attack. An MI occurs when blood stops flowing properly to a part of the heart, and the heart muscle is injured because it is not receiving enough oxygen. Biochemical tests are restricted to monitoring cardiac enzymes activities. Therefore, introducing homocysteine test in hospitals for MI patients may provide a clearer picture on the patient condition and help in the disease management.The study was conducted during the period from October 2015 till August 2016. Sixty - three of the people who have a history of injury in the acute myocardial infarction are studied. The diagnosis is based on the clinical presentation and confirmed by ECG, and cardiac enzyme. Forty - eight of persons as healthy volunteers were selected as a control group.The results indicated the following : The proportion of patients male (57%) and females (43%), smokers (49%) and non - smokers (51%), most of them are females. The results also showed that (32%) live in cities, compared to (68%) live in rural areas, and patients Serum homocysteine was significantly higher in MI patients compared to the control group. Homocysteine levels were higher in smokers(p = 0.0001). and unemployed individuals(p < 0.0001)., as well as in individuals with family history of MI or CAD(p < 0.0001). High hypertensive, diabetic and obese individuals had also higher levels of homocysteine . Based on the results of this study suggested measuring the amino acid Homocysteine levels of security as one of the effective ways to diagnose patients with myocardial infarction in hospitals

دراسة كيمو حيوية مقارنه للاجهاد التاكسدي وانماط الدهون في المرضى كبار السن المصابين بمرض الارتجاف الاذني في محافظة ذي قار العراق == A Biochemical Comparative Study of Oxidative Stress and Lipid Profile in Elderly Patients With Atrial Fibrillation in Thi - Qar Governorate/Iraq

اسم المؤلف: سارة عاشور ساير
اسم المشرف: رائد معلك حنون الصالح | عدنان الطعان الخفاجي
الموضوع العام: علوم الكيمياء
السنة: 2017
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: Atrial fibrillation (AF) is the most common cardiac arrhythmia in the general population, and a major cause of morbidity and mortality. Lifetime risk for development of AF has been estimated to 1 in 4 in individuals aged 40 years or more.The present study is designed to determine the levels of oxidative stress by measuring lipid peroxidation product (malondialdehyde MDA), antioxidant state by measuring some antioxidants such as (ceruloplasmin Cp, Transferrin Tf, albumin Alb ,uric acid Ua) ,in addition to lipid profile (cholesterol TC, triglyceride TG, high density lipoprotein cholesterol HDL - C, low density lipoprotein cholesterol LDL - C and very low density lipoprotein cholesterol VLDL - C) in atrial fibrillation patients .The study included (150) subjects; (75) normal subjects (control) and (75) patients with atrial fibrillation. The patients are divided into two groups according to the age : (39) elderly patients [the age range (60 - 80) years] and (36) others patients [the age range (20 - 59) years], also patients are divided in to two groups according to the age with one or more risk factor (Hypertention (HTN), Ischemic Heart Disease(IHD), Heart Hailure (HF)) : elderly which included (18) patients (lone AF) , (21) patients (AF with HTN, IHD, HF) and others which included (17) patients (lone AF), (19) patients (AF with HTN, IHD, HF).The normal subjects (control) also divided into two groups according to the age : elderly [the age range (60 - 80) years] and others [the age range (20 - 59) years] .According to age, the results shown significant increase in the concentration of serum (MDA, Cp, uric acid, TC, TG, VLDL - C, LDL - C ) in elderly and other groups in comparison with their control groups (p≤0.05). It was found significant increase in the concentration of serum MDA in elderly group in comparison with other group, also it was found significant increase in the concentration of serum uric acid in control elderly group in comparison withXIVcontrol other group (p≤0.05). The results also showed non significant differences in the concentration of serum (Cp, uric acid, TC,TG, LDL - C, VLDL - C) between elderly and other groups. It was also found non significant differences in the concentration of serum ( Cp, TC, TG, LDL - C, VLDL - C) between control elderly and control other groups (p≤0.05). While serum Alb , serum Tf and serum HDL - C concentrations show a significant decrease in elderly and other groups in comparison with their control groups (p≤0.05). The results showed significant decrease in the concentration of serum HDL - C in control elderly group in comparison with control other group. Also there were no significant differences in the concentration of serum Alb serum Tf and serum HDL - C between elderly and others groups (p≤0.05).According to the age with one or more risk factor (HTN, IHD, HF) the results show a significant increase in the concentration of serum (MDA, Cp , uric acid, TC, TG, VLDL - C , LDL - C ) in elderly and other groups in comparison with their control groups (p≤0.05). It was found a significant increase in the concentration of serum MDA in the groups AF and AF with HTN, IHD, HF ( in elderly groups) in comparison with groups AF and AF with HTN, IHD, HF (in other groups) respectively (p≤0.05). It was also found a significant increase in the concentration of serum uric acid in control elderly groups in comparison with control other groups , also there were no significant differences in the concentration of serum (CP ,TC , TG ,VLDL - C, LDL - C) between elderly and other groups (p≤0.05). serum Alb ,serum Tf and serum HDL - C show a significant decrease in elderly and other groups in comparison with their control groups, also there was significant decrease in the concentration of serum HDL - C in control elderly groups in comparison with control other groups (p≤0.05). It was also found non significant differences in the concentration of serum Alb and serum Tf between elderly and other groups (p≤0.05).

تحضير وتشخيص ودراسة بايولوجية لمشتقات جديدة من - 3,4,0 اوكسادايزول و3,4,0 - ثايادايازول ومعقداتها مع بعض العناصر الانتقالية واستخدامها في استخلاص الكوبلت الثنائي == Synthesis, Characterization, and Biological activity Study of New 1,3,4 - Oxadiazole and 1,3,4 - Thiadiazole Derivatives and Some of Their Transition Metal Complexes and Using in extraction of cobalt ion (ll)

اسم المؤلف: ازهار حميد كاطع
اسم المشرف: ساهر عبد الرضا علي | ابراهيم عبود فليفل
الموضوع العام: علوم الكيمياء
السنة: 2016
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: The thesis include preparation and characterization of some new derivations of 1,3,4 - oxadiazole and 1,3,4 - thiadiazole as ligands which are : - L1 = 2,2' - [(1E,2E) - ethane - 1,2 - diylidenedi(2E)hydrazin - 1 - yl - 2 - ylidene]bis(5 - methyl - 1,3,4 - oxadiazole) L2 = 2 - hydrazinyl - 5 - [(2E) - 2 - {(2Z) - 2 - [2 - (5 - hydrazinyl - 1,3,4 - thiadiazol - 2 - yl)hydrazinylidene]ethylidene}hydrazinyl] - 1,3,4 - thiadiazole L3 = 2,2' - {1,3,4 - thiadiazole - 2,5 - diylbis[(1E)hydrazin - 2 - yl - 1 - ylidene(E)methylylidene]}bis(6 - methoxyphenol) with structural formula L1 L2 L3 The new complexes were prepared from the reactions of ligands L1,L2,L3 with the transition metal salts (CrCl3.6H2O, COCl2.6H2O,NiCl2.6H2O) . The elemental analysis (CHN) , Infrared(IR) Spectroscopy , Nuclear Magnetic Resonance Spectroscopy (1H - NMR) , Mass Spectra , Magnetic Susceptibility and Molar conductivity techniques were used to characterize the structural formula of these ligands and their complexes.1) The complexes of [Cr(III) , Co(III)] for all ligands have shown octahedral configuration. 2) Complexes of [Ni(II)] with all ligands have shown square planar configuration.liquid - liquid extraction using L2 as extracting agent , The best results were obtained from liquid - liquid extraction in which Co(ll) had a 95% extraction rate at pH 9 ,temperature degree at 40 C0 Testing the biological activity for ligands and their complex by using spreed method and measurement inhibition zone by using (DMSO) as solvent and erythromycin as standard bactericidal , using in this study two types from bacteria one gram negative bacterial strains (Escherichia coli ) and other isgram positive bacteria strains staphylococcus aureus

ازالة صبغات الثيازين باستخدام تقنية الموجات فوق الصوتية وبعض طرائق الاكسدة المتقدمة == Removal of Thaizine dyes by using sonolysis Technology and Some Advanced Oxidation Processes

اسم المؤلف: الاء طالب حمزة
اسم المشرف: حسن عباس حبيب
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء الفيزيائية
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تناول البحث الحالي استعمال طرائق الاكسدة المتقدمة Advanced Oxidation Processes (AOP,S) المتمثلة ﺑ تقنية الموجات فوق الصوتية (US) والموجات فوق الصوتية مع الاشعة فوق البنفسجية (US/UV) والموجات فوق الصوتية والاوزون (US/O3) . لغرض تجزئة اصباغ الازور (AzureC, AzureB, AzureA) وازالة الوانها كما وتضمنت هذه الدراسة دراسة تاثير تركيز الصبغة الابتدائي, ودرجة الحرارة , وpH المحلول , وشدة الضوء المستعمل وسرعة الغاز على عملية تجزئة هذه الصبغات, بالاضافة الى ذلك تم استعمال طريقتي الاكسدة الضوئية المتمثلة ﺑ الاشعة فوق البنفسجية والاوزون (UV/O3) وتقنية الموجات فوق الصوتية والاشعة فوق البنفسجية والاوزون (US/UV/O3) وبظروف مثلى متمثلة في اوطا تركيز واعلى درجة حرارة وpH وشدة للضوء وسرعة للغاز والمقارنة بينها وبين الطرائق السابقة في كفاءة الازالة للصبغات. تم اجراء التجارب جميعها باستعمال جهاز مولد الموجات فوق الصوتية(Power Sonic LUC - 410) وتحققت التجزئة التامة في فترة زمنية قصيرة نسبيا (60 min) من التشعيع ولوحظ ان اسرع ازالة للون تمت في pH=8)) اي ودرجة حرارة (35oC) . كما لوحظ ان اﻔﺿل النتائج تم الحصول عليها باستخدام تقنية الموجات فوق الصوتية والاوزون (US/O3) في فترة (60 min) اما بالنسبة للطرائق التي اجريت لاحقا تبين ان اعلى نسبة ازالة تم الحصول عليها باسخدام طريقة (UV/O3) في فترة (15 min) اما بالنسبة لطريقة (US/UV/O3) كانت اعلى نسبة ازالة في (10 min) كما بينت النتائج ان سرعة الازالة تزداد بزيادة pH , وشدة الضوء المستعمل , وسرعة الهواء , ووجد ان نسبة الازالة تزداد بزيادة درجة الحرارة التي تسبب خفض طاقة التنشيط وكانت قيم طاقة التنشيط لعملية الازالة للصبغات (AzureC AzureB, AzureA) حسب الطرائق المذكورة انفا كالاتي , (16.7,15.3,16 KJ.mol - 1) على التوالي عند التشعيع بالموجات فوق الصوتية و(15,14.2,14.8 KJ.mol - 1) عند التشعيع بالموجات فوق الصوتية والاشعة فوق البنفسجية و(14,13.5,13.8 KJ.mol - 1 )عند التشعيع بالموجات فوق الصوتية والاوزون. كما اوضحت النتائج التي تم الحصول عليها ان سرعة الازالة تتبع حركيات المرتبة الاولى الكاذبة باستخدام الطرائق المذكورة انفا. | This research investigate of the efficiency of advanced oxidation processes (AOP,S), ultrasound alone (US) , ultrasound combined with ultraviolet (US/UV) and ultrasound combined with ozone (US/O3) for decolorizing of textile dyes (Azure A, Azure B, Azure C) in aqueous solution . The effect of dye concentration, temperature, pH, light intensity and rate flow gas on the removal process of dyes was also investigated. A comparative study with the above methods was also performed by using (UV/O3) and (US/UV/O3) in optimize process conditions are : lower concentration, higher temperature ,pH, light intensity, and rate flow gas to treat three Azure dyes. All experiments has been done be using ultrasonic reactor technology (Ultrasonic LUC - 410). Complete Dyes degradation has been achieved in a somewhat short period (60 min), and the maximum removal of color occurred at (pH=8) and temperature (35oC). The maximum removal of dye occurred by using ultrasound in combination with ozone in (60 min), with respect to the other methods, the maximum percent removal of dyes by using(UV/O3) method in (15min), While the maximum removal occurred at (10 min) by using (US/UV/O3) method. The results have shown that the rate of removal increases with decrease initial dye concentration, and increases in pH, light intensity, gas flow rate, and temperature, the increase in temperature caused a decrease in activation energy. It noticed that activation energy values of dye in three methods are : (16, 15.3, 16.7 KJ.mol - 1) for (Azure A, Azure B, Azure C) respectively, in ultrasound method only, (14.8, 14.2, 15 KJ.mol - 1) for (Azure A, Azure B, Azure C) respectively, in ultrasound with ultraviolet method, and (13.8, 13.5, 14 KJ/mol - 1) for (Azure A, Azure B, Azure C) respectively, in ultrasound with ozone method. The results was also showed that the rate of removal followed pseudo first order kinetics by using the methods mentioned above.

تحضير وتشخيص ليكاند قاعدة شف جديدة مشتقة من 4 - امينو انتي بايرين ومعقداتها مع بعض الايونات الفلزية ودراسة فعاليتها المضادة للبكتيريا == Synthesis And Characterization of New Schiff Base Ligand Derived From 4 - Aminoantipyrine And It'S Complexes With Some Metal Ions And Their Antibacterial Effective Study

اسم المؤلف: هيام هادي علكم
اسم المشرف: ساجد محمود لطيف
الموضوع العام: علوم الكيمياء
السنة: 2013
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تضمن البحث تحضير ليكاند قاعدة شف جديدة (L) ثنائية السن نوع (NO)1,5 - dimethyl - 4 - ( 2 - oxo - 1,2 - diphenyl ethylidene amino) - 2 - phenyl - 1,2dihydropyrazol - 3 - one.وذلك من مفاعلة 4 - aminoantipyriene مع Benzil باستعمال الايثانول وسطا للتفاعل. | This work covers the synthesis and characterization of the new Schiff base bidentate ligand(L) type (NO) 1,5 - dimethyl - 4 - (2 - oxo - 1,2 - diphenylethylidene amino) - 2 - phenyl - 1,2 dihydropyrazol - 3 - oneThe ligand (L) was prepared from reaction of 4 - aminoantipyrine with Benzil under reflux in ethanol solvent. The Ligand Complexes for the metal ions : VO(II) ,Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) and Hg(II) were prepared. The Ligand and its complexes were characterized by spectral methods [FT - IR , UV - Vis , Atomicabsorption , 1HNMR ] in addition to molar conductivity , Microanalysis (C.H.N) , Magnetic moment effect and melting point and mole ratio Ligand : Metal. From the above data for the ligand and its complexes , we suggested that the ligand (L) behaves as bidentate on complexation with metal ions Via Natom of ( C = N) group and O atom for ( C = O) of pyrazol ring. The suggested molecular formula and geometrical structure are : 1 - Squarepyrimide for [VO(L) (SO4) (H2O) ] 2 - Tetrahedral for [M(L)Cl2]. n H2O M = Zn (II) , n = 1 M = Cd(II) and Hg(II) ; n =0 3 - Octahedral for [M(L)2Cl X ]. Y M = Mn(II) , X = Cl , Y = H2O M = Co(II) , Ni(II) and Cu(II) X = H2O , Y = Cl

تحضير وتشخيص بعض المعقدات الفلزية احادية ومختلطة الليكاند المشتقة من سلفاميثاكزول و4,4' - ثنائي مثيل - 2,2' - باي بريدال == Synthesis And Characterization of Some Metal Complexes With Mono And Mixed Ligand Derived From Sulfamethoxazole And 4,4' - Dimethyl - 2,2' - Bipyridyl

اسم المؤلف: ميسون مزهر عـبد الحسـن
اسم المشرف: محاسن فيصل الياس
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء اللاعضوية
الدرجة: ماجستير
الجامعة: جامعة بغداد - كلية العلوم للبنات
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تم في هذا البحث تحضير معقدات جديدة للعناصر الثقيلة Rh(III)} وPd(II) Pt(IV)و {Au(III) من تفاعل الليكاند (sulfamethoxazole L1) مع ايونات املاح هذه الفلزات بالطريقة التقليدية وتم تحضير معقدات جديدة اخرى في الحالة الصلبة بواسطة تفاعل مزيج من (sulfamethoxazol | In the present study, new heavy metal complexes of sulfamethoxazole (SMX) as L1 have been prepared with Pd(II), Au(III), Rh(III) and Pt(IV) ions , in a solid state by conventional method. Two mixed ligands were chosen : sulfamethoxazole and 4,4/ - dimethyl - 2,2/ - bipyridyl (L2). This is done to prepare another series of complexes with some metal ions ( Co(II), Ni(II), Cu(II), Cd(II), Cr(III) , V(IV), Pd(II) and Au(III)) in order to investigate the coordination behavior of these ligands(L1) and (L2) toward these metal ions.These complexes, already prepared by the solid state, were characterized by the elemental analysis (C.H.N.S) and FT - IR , UV - Vis spectroscopy, in addition to the flame atomic absorption, magnetic susceptibility , melting point and conductivity measurements. According to the results obtained, it is noticed that ligand L1, with the light and heavy metal ions, clearly behaves as a bidentate through the O atom of sulfonyl group and N atom of sulfonylamid group for all the prepared complexes except Cu(II) and Ni(II). In this case, the ligand confirms that the bonding of the metal ion in a tridentate chelate through the O atom of sulfonyl group and N atom of sulfonylamid group and N atom of amine group.While L2 behaves as a bidentate ligand through two N atom. Conductivity measurements have shown that all the prepared complexes are ionic except PdL1L2 complex. Based on the results of the measurements, the following formula have been suggested for the new prepared complexes : - [VOL1L2]SO4.2H2O and [CuL1L2]2( NO3)4.0.5H2O have square pyramidal geometry while the following complexes are having octahedral geometry : - [CrL1L2 Cl2] Cl.H2O,[NiL1L2NO3]2 ( NO3)2.0.5 H2O,[PdL1L2 Cl2].0.5H2O,[PtL1Cl3H2O]Cl.H2O, [Au L1L2Cl2] Cl.2H2Oand the complexes below have tetrahedral geometry : - [CoL1L2] (NO3)2.3H2O,[CdL1L2](NO3)2.3H20 while [PdL1Cl]2 Cl2.H2O,[AuL1Cl2]Cl.3.5H2O,[RhL1ClH2O]Cl2.0.5H2O have square planar geometry.Different bonding and structural behaviors were revealed throughout the study of coordination chemistry of the newly prepared metal complexes.The nature of bonding between the metal ion and the donor atoms of the ligands were demonstrated by calculating Racah parameter and the other ligand field parameters which were calculated using suitable Tanaba - Sugano diagrams.The nature of the complexes in ethanol solution was studied for some of the prepared complexes such as (RhL1,PdL1,PtL1 and AuL1) in the solution state to determine the ratio between ligand to metal state by using the molar ratio method which gave results which approximately identical results when compared to those obtained from the isolated solid state. Besides the stability constant of the prepared complexes were studied and it was found that they were stable in molar ratio 1 : 1.

تحضير وتشخيص مشتقات جديدة للكومارين - 3 - كاربوكسلك اسيد == Synthesis And Characterization of New Derived From Coumarin - 3 - Carboxylicacid

اسم المؤلف: كوثر عبد الواحد عبد الحميد
اسم المشرف: شذى فاضل نارين الزبيدي
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء العضوية
الدرجة: ماجستير
الجامعة: جامعة بغداد - كلية العلوم للبنات
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعد مشتقات الكومارين مهمه من الناحية البايلوجية والصناعيه والدوائيه وعلى هذا الاساس استمرت الدراسات في تحضيرمشتقات جديده للكومارين وعليه فقد تم في هذا البحث تحضير عدد من مشتقات للكومارين وعددها 23)) بالاضاقة الى المركب 2 - oxo - 2H - coumarin - 3 - carbox | The coumarin and his derivatives class of heterocyclic compoundsThey are presente in a large family of products with broad biological and industrial activities.This fact leads as to synthesis twenty eight compounds of heterocyclic by several methods show in diagrams (1, 2).Than we characterized this compounds by some spectral analysis Such as : (FT - IR), (GCMS), (H - NMR) and determination of their physical properties such as melting points and color.This work involved : 1. Synthesis of base compound ( coumarin 3 - carboxylic ) by reaction Malonic acid with Salicylaldehyde in Petroleum ether as a solvent.2. Synthesis of k1 by reaction ( coumarin 3 - carboxylic ) with Thionyl chloride in Dichloro methane as a solvent.3. Synthesis of k2 by reaction k1 with hydrazine hydrate 99%. 4. Reaction k2 with six kinds of aromatic aldehyde to Synthesis of Schiff Bases : K8 - k7 - k6 - k5 - k4 - k35. Synthesis of five from Tetrazoles compounds by reaction Schiff Bases With sodium azide in dioxane as a solvent. 6. Synthesis of five from thiazolidinone compounds by reaction Schiff Bases with Mercapto acetic acid in THF) as a solvent. 7. Synthesis of five from azetidinone compounds by reaction Schiff Bases with ChloroacetylChloride in Dioxane as a solvent. 8. Synthesis of five of thiourea compounds by reaction Schiff Bases with thiourea in methanol as a solvent.

دراسة دورالانترلوكين - 36 كاما والبارااوكزونيز وحامض السياليك ومتغيرات اخرى في مصل المريضات بهجرة بطانة الرحم في بغداد == Study The Role of Interleukin - 36? , Paraoxonase , Sialic Acid And Other Parameters In Sera of Endometriotic Patients In Baghdad

اسم المؤلف: رشا زهير جاسم
اسم المشرف: زهير ابراهيم المشهداني | بشرى حميد علي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء الحياتية
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Endometriosis , a chronic inflammatory autoimmune disease, is among one of the most challenging of the 21st century that affects women in reproductive age. Seventy five consecutive married women endometriotic patients with age range (25 - 40) year were enrolled in this study , divided into three groups , the first included twenty five newly diagnosed endometriotic patients ( without any treatment) , the second consisted of twenty five endometriotic patients who were treated with zoladex for 3 to 5 months , the third involved twenty five patients with recurrent endometriosis (post treatment of zoladex) for one to two years ago. Patients groups were compared with two matched age and sex control groups , control group included twenty five healthy women while pathological control group involved twenty five women suffering from infertility caused by gynecological disorders not linked with endometriosis. The present study highlights the role of some morphological characteristics (BMI and W/H) , immunological / inflammatory aspect (Interleukin - 36 ? , Angiopoietein - 2 , Tumor Necrosis Factor - ? , Immunoglobulin G , Immunoglobulin A , Immunoglobulin M , Sialic acid ) , oxidative aspect (Total Cholesterol , Triacylglycerol , High Density Lipoprotein cholesterol , Low Density Lipoprotein cholesterol , Very Low Density Lipoprotein cholesterol , Paraoxonase - 1 , Ceruloplasmin ) and hormonal aspect (estrogen) in the pathogenesis of endometriosis. …………… Results have revealed that endometriotic patients have approximately a normal BMI and lower than pathological control group, but it was increased in patients under treatment with zoladex. A greater W/H ratio was associated with both endometriosis and pathological control group , while W/H was approximately not affected after treatment with zoladex. The present study have reported for the first time a positive relationship between IL - 36? , Sia and endometriosis. Those parameters could be considered novel biochemical markers in endometriosis because their levels were higher in sera of endometriotic patients without treatment compared with control and pathological control groups. Moreover , Ang - 2 appears to be a good biochemical marker in endometriotic patients. Hence, Ang - 2 levels were higher in sera of endometriotic patients compared with control and pathological control groups In contrast high levels of TNF - ? are associated not only with endometriosis but with pathological control group also. IgA and IgM could be used as possible biochemical markers for endometriosis. The present study is the first dealing with zoladex action on depressing IL - 36? , Ang - 2 , Sia while TNF - ?, IgG , IgA, IgM were decreased under treatment with zoladex. The present study have also suggested that TC and LDL - could be used in diagnosis of endometriosis , HDL - c levels were lower in patients without treatment compared with control and pathological control, but elevation obsereved under treatment with zoladex. PON - 1 activity was low in sera of patients while it was increased after treatment. Furthermore , this is the second study that proves a positive relation between CP and endometriosis and the first dealing with zoladex role on decreasing CP level in endometriosis. Lastly , estrogen was higher in endometriosis compared with control and pathological control groups , while it was decreased by zoladex action

تحضير وتشخيص بعض الليكندات الحلقية غير المتجانسة الجديدة وبوليمراتها الكلابية ودراسة انتقائيتها في استخلاص بعض الايونات == Synthesis And Characterization of Some New Cyclic Legand And Chelating Polymer And The Study of Their Selectivity for Some Ions

اسم المؤلف: احمد جاسم محمد الحوري
اسم المشرف: علي طه علي السامرائي | غزوان حسن الصميدعي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: In this study ,some Chalcons were prepared by using terphthaldehyde with aromatic ketone compounds in basic surrounding NaOH 10% ,adopting the basic medium rought ,compound that were prepared was studied by infrared (IR) , Nuclear Magnetic Resonance(NMR) and (CHN). table below includes numbers and structure of the prepared ChalconsCompound Structure Compound name No. (2,2') - 3,3' - (1,4 - phenylene) bis(1 - pyridin - 2 - yl)prop - 2 - en - 1 - one) 1 (2,2') - 3,3' - (1,4 - phenylene) bis(1 - pyridin - 3 - yl)prop - 2 - en - 1 - one) 2 (2,2') - 3,3' - (1,4 - phenylene) bis(1 - pyridin - 4 - yl)prop - 2 - en - 1 - one) 3 (2,2') - 3,3' - (1,4 - phenylene) bis(2 - hydroxyphenyl)prop - 2 - en - 1 - one) 4 (2,2') - 3,3' - (1,4 - phenylene) bis(2,5 - dihydroxyphenyl)prop - 2 - en - 1 - one) 5 (2,2') - 3,3' - (1,4 - phenylene) bis(4 - hydroxyphenyl)prop - 2 - en - 1 - one) 6 (2,2') - 3,3' - (1,4 - phenylene) bis(1 - phenylprop - 2 - en - 1 - one) 7Solution of (Cu2+,Mg2+,Hg2+,Ca2+,Co2+,Cd2 +,Cr3 +,Ni2+) metal ions in ethanol tested with solution of the prepared ligands in ethanol using spot test method ,compound (1) showed colored complex with Ni2+ ions, the complex was studied as a solution for the color metal determination of Ni2+ ions, metal to light ratio and calibration curve for Ni2+ ions, were established.The prepared chalcones were supported on rigid polymer than foam and the produced chelating polymers were evaluated for their loading capacity towards (Pb2+,Ni2+,Cu2+,Cr2+, Cd2+, Co2+,Mn2+,Zn2+) ions , the resins showed no response toward (Mn2+ and Zn2+ ) ions, and Avery low loading capacity towards ( Cr2+ and Cd2+) ions, but the studied resins showed a good resins toward the rest of the studied ions (Pb2+,Ni2+,Cu2+,Co2+) The effect of treatment time and pH on the loading capacity of the resins were studied while other parameters , like temperature ,weight of resin and metal ion concentration were kept constant. The results of max. loading capacity were as shown in the table below : Resin Loading Capacity (mg ion / gm resin) Ni2+ Pb2+ Cu2+ Co2+R1 8.8 9.5 8.9 8.6R2 7.5 7.8 7.3 7.0R4 8.9 9.3 9.1 8.5R5 8.7 9.3 8.4 8.2 A study of the recovery of ions from resins [(R1),(R2),(R4),(R5)] and the regeneration of the resin were also the studied carried out using 3M HNO3 as an eluent, the table below shows the %recovery of each ion from the studied resins.Resin Recovery % Ni2+ Pb2+ Cu2+ Co2+R1 64.8 74.6 52.9 49.2R2 64.5 76.4 51.2 47.6R4 44.0 61.1 52.4 48.7R5 48.1 68.6 57.4 50.1

تحضير ودراسات طيفيه لمعقدات ليكاندات الاميدوبنزوثايزول الممزوجه باستخدام الطريقه المايكرويفية == Synthesis And Spectral Studies of Amide Benzothiazole Mixed Ligands Complexes Using Microwave Method

اسم المؤلف: فرح سعدون جعفر
اسم المشرف: محاسن فيصل الياس
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء اللاعضوية
الدرجة: ماجستير
الجامعة: جامعة بغداد - كلية العلوم للبنات
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: في هذا البحث تم استخدام احدى تطبيقات الكيمياء الخضراء حيث حضرت المعقدات بالطريقة المايكرويفيه حيث تتيح هذه الطريقه ظروف افضل للعمل من حيث تقليل التلوث ,استخدام كمية مذيب اقل, اقل تكلفة, نسبة منتوج عاليه , تفاعل بزمن اقصر وكطريقة عمل ابسط.تم استخدام ليكا | One of green chemistry applications has been used in this work ,where the complexes were prepared by microwave irradiated reactions that availed reduced pollution, free or less solvent conditions, low cost, high yields, shorter reaction times and simplicity in processing. Two of benzothiazole derivatives ligands 2 - benzamid benzothiazole (L1) and 2 - acetamid benzothiazole (L2) were used to synthesize two types of transition metal complexes ; Rh(III), Pd(II), Cd(II), Pt(IV) and Au(III) , the other set of complexes was prepared in presence of a co - ligand 1,10 - phenanthroline(L') or 4,4? - dimethyl - 2,2? - bipyridyl (L") with the metal ions V(IV), Cr(III), Co(II), Ni(II), Cu(II), Zn(II) and Au(III) using microwave and conventional methods to compare the results between them. These ligands and their metal complexes were isolated and characterized in solid state using FT - IR, UV - Vis spectroscopy, flame atomic absorption, elemental analysis C.H.N.S. and magnetic susceptibility measurements as well as melting point and conductivity measurements. According to the results of the above measurements, the following shapes were suggested for the prepared complexes : Complexes of ligand (L1) : Complexes of Rh(III), Pd(II) and Au(III) have a square planar geometry, while Cd(II) complex has a Td geometry and Pt(IV) complex has an Oh geometry.Complexes of mixed ligands (L2 with L'/ L") : All complexes have an Oh geometry except V(IV) complex has a square pyramid and Co(II) complex has a Td geometry. The nature of bonding between the metal ion and the donor atoms of the ligands was demonstrated through the calculation of Racah parameter and other ligand field parameters, which were calculated using suitable Tanabe - Sugano diagrams.The nature of some (L1) complexes in liquid state was studied by following the molar ratio method which gave results approximately identical compared with those obtained from the isolated in the solid state; also, stability constants of the prepared complexes were studied , they were stable in the molar ratio 1 : 1. A theoretical treatment of the ligands and the prepared complexes in gas phase was done using two programs; Hyperchem - 8 and Gaussian program (GaussView Currently Available Versions (5.0.9) along with Gaussian 09 which is the latest in the Gaussian series of programs).Hyper chem. - 8 program used the molecular mechanics and semi - empirical calculation, the heat of formation (?H?f), binding energy (?Eb) dipole moment (µ) for the free ligands and their metal complexes were calculated using ZINDO/1, PM3 and AMBER methods at 298 K. It was found that the complexes were more stable than their ligands; furthermore, the electrostatic potential of free ligands was calculated to investigate the reactive site of the molecules, PM3 was used to evaluate the vibrational spectra of free ligands ,the obtained frequencies agreed well with those values experimentally found; in addition, the calculation helped to assign unambiguously the most diagnostic bands. Electronic spectra measurements for the ligands were calculated theoretically using ZINDO/S method comparing it with the experimental results. It was found that there was a closely relationship between the theory and experimental spectra.Gaussian program semi - empirical (PM3) method which used in order to calculate : the geometry optimization, dipole moment (?),total energy ,electrostatic potential, ELUMO and EHOMO was obtained, evaluate the vibrational spectra of free ligands and these obtained frequencies agreed well with those values experimentally found.Also electronic spectra measurements for the ligands were calculated theoretically by using the job type : Single point energy (SP) along with ZINDO method and also the job type frequency (Freq) used along with CIS method (3 - 21G).

التقدير الطيفي لبعض المركبات الفينولية ذوات الاهمية الصيدلانية == Spectrophotometric Determination of Some Phenolic Compounds of Pharmaceutical Importance

اسم المؤلف: زينب طالب عبد الكاظم السلطاني
اسم المشرف: قاسم حسن كاظم
الموضوع العام: علوم الكيمياء
السنة: 2013
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يتضمن الفصل الاول مقدمة عن تفاعلات الازوتة والازدواج واهميتها وتطبيقاتها في تقدير المستحضرات الصيدلانية، وتضمن ايضا عرضا لبعض الاستخدامات الطبية والصيدلانية للمركبات الفينولية الدوائية المدروسة واستعراضا موجزا للطرائق التحليلية المستخدمة في تقدير المرك | The first chapter included a common introduction on diazotization coupling reaction and their applications to the determination of pharmaceutical preparations. It also included a display of some of its pharmaceutical and medical uses. The chapter also demonstrates a brief review for the analytical methods that have been used for the determination of thymol, Sodium salicylate and Resorcinol in pharmaceutical preparations.The second chapter comprises to describe a simple and sensitive spectrophotometric method for the determination of thymol in aqueous solution, based on the coupling of thymol with diazotized 4 - bromo aniline in strong alkaline medium to produce an intense yellow colored ,water - soluble and stable Azo - dye which exhibits maximum absorption at 464nm. Beer’s law was obeyed between 0.6 - 7.2 µg.ml - 1, with a molar absorptivity of 3.0284×104 l.mol - 1.cm - 1,average recovery was 100.002%, and RSD was 0.796%, the LOD was 0.04?g.ml - 1 and LOQ was 0.1333?g.ml - 1. The method has been applied successfully for the determination of thymol in pharmaceutical preparations (mouthwashes) and the analytical results were compatible with certified value of pharmaceutical preparations and with a standard method. Moreover, the accuracy and validity of the method was evaluated against a standard method using F and t - tests. It was found that experimental F and t values at 95% confidence level did not exceed the critical values indicating that the present proposed methods have a good accuracy and validity. The third chapter demonstrates the development of simple and sensitive spectrophotometric method for the determination of microgram amounts of Sodium salicylate in some of its pharmaceutical preparations based on the coupling and Azo reaction to form an intense shine - yellow, water - soluble dye based on the coupling of Sodium salicylate with diazotized p - amino benzoic acid reagent in strong alkaline medium The dye formed has a maximum absorption at a wavelength of 452 nm. Beer’s law was obeyed between 2 - 30 µg.ml - 1, with a molar absorptivity of 8.5013×103 l.mol - 1.cm - 1, the LOD was 0.06?g.ml - 1 and LOQ was 0.213?g.ml - 1. The method had a good accuracy and precision, since the recovery was 99.702% and the RSD was 0.854%.. The method has been applied successfully in some pharmaceutical preparations including salicylic acid (topical solution). The analytical results agreed well with British pharmacopia method. Moreover, the accuracy and validity of this method were evaluated against pharmacopoeia method using F and t - tests. It was found that experimental F and t values at 95 % confidence level did not exceed the theoretical values indicating that the present method have good accuracy and validity. The fourth chapter comprises the description of a sensitive spectrophotometric method for the determination of resorcinol by diazotization reaction using a diazotized 4 - methoxy aniline reagent in strong alkaline medium, to form brown water - soluble colored dye. Which exhibits maximum absorption at 448 nm. The linear range was between 0.4 - 4.4 µg.ml - 1, with a molar absorptivity of 2.7844×104 l.mol - 1.cm - 1, average recovery of 101.017%, RSD was 1.02%, LOD was 0.019 µg.ml - 1 and LOQ was 0.065 µg.ml - 1. By the application of the proposed method on the some pure types resorcinol, it was found that the results agreed well with British pharmacopeia method. Moreover, the accuracy and validity of this method were evaluated against pharmacopoeia method using F andt - tests. It was found that experimental F and t values at 95 % confidence level did not exceed the theoretical values indicating that the present method have good accuracy and validity.

دراسة بعض المتغيرات الكيموحيوية لمرضى التهاب الكبد الفيروسي والعجز الكلوي المزمن == Study of Some Biochemical Parameters for Patients With Hepatitis And Chroinc Renal Failure

اسم المؤلف: ايناس حازم حميد الجنابي
اسم المشرف: صباح حسين خورشيد | فراس طاهر ماهر
الموضوع العام: علوم الكيمياء
السنة: 2013
الموضوع الدقيق: الكيمياء الحياتية
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: اجريت هذه الدراسة الحالية لتحديد العلاقة بين حالات الاصابة بالتهاب الكبد الفيروسي والعجز الكلوي المزمن ومستويات تركيز الفيوكوز الكلي (TF), والفيوكوز المرتبط بالبروتين (PBF) , والسكريات السداسية المرتبطة بالبروتين (PBHex) , وعدد من المتغيرات الكيموحيوية ال | The study was done to determine the relationship between hepatitis and chronic renal failure and total fucose (TF) level , protein bound fucose (PBF) , protein bound hexose (PBHex) and other biochemical parameter , which include : urea , creatinine, total bilirubin(direct_indirect), some enzyme [Alanine Transaminase Transaminase (AST) , (ALT) Aspartate Transaminase ] , electrolytes [Sodium (Na+) , Potassium (K+) ] ,and calicum ca++.This study included (50 ) patients of both sexes at age groups (3 - 70) , with hepatitis, and (50 ) patients of both sexes at age groups (15 - 70) with chronic renal failure, all patients have divided in to groups according to sex , age , and the duration of the disease. also the study included (50) healthy persons of both sexes at same age groups regarded as control groups. , and tending some of patients before,during and after dialysis ,so measuring biochemical parameter included three parts : - The first part measuring biochemical parameter in control, chronic renal failure before dialysis, where the results indicate - Results showed highly significant increase in TF, PBF, PBHex, Urea, Creatinine , K+ in relation to control group. while a slightiy difference between hepatitis & chronic renal failure, and a slightiy difference between male and female. - No significant differences in total bilirubin(direct and indirect), of chronic renal failure patients. - A low significant decrease of Na+ , Ca++ in the serum of chronic renal failure patients in compare to control group, and a slightiy difference between males and females.Measuring during dialysis showed - A highly significant increase(>0.01) in Urea ,Creatinine , K+ , and no difference in TF, PBF , PBHex level compared to their concentration befor dialysis. - A significant decrease in Na+,Ca++ in relation to their concentration befor dialysis. - No significant difference in total bilirubin(direct and indirect), AST,ALT compared levels to their concentration befor dialysis. - Measuring after dialysis showed - No significant difference in Urea , Creatinine Na+ , K+, Ca++ compared to their concentration with control group. - No significant difference in total bilirubin(direct and indirect), AST ,ALT levels compared to their concentrations in chronic renal failure befor and during dialysis and no changes in TF, PBF , PBHex levels compared to their concentration befor dialysis and during dialysis. - The study concluded that then results of hemodialysis results in improvement in some biochemical parameters of chronic renal failure and that the fucose level did not change during hemodialysis. - The study also concluded that there was an increase in TF , PBF , PBHex , AST , ALT and total bilirubin(direct and indirect) in the serum of patients with hepatitis in comparism with control group and for both sexes,while there was no change in Ca++ , K+ , Na+ , Urea , Creatinine level for both sexes in the serum of patients with hepatitis compared to control.

تحضير ودراسة بايوكيميائية للادوية المصاحبة الاسترية الحاوية على دواء الاسبرين او الايبوبروفين == Synthesis And Biochemical Study of Ester Prodrugs Containing Aspirin Or Ibuprofen

اسم المؤلف: نوري محمد عزيز فياض الجبوري
اسم المشرف: فراس شوقي عبد الرزاق | اياد سعدي حميد
الموضوع العام: علوم الكيمياء
السنة: 2011
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: يعد الاسبرين والايبوبروفين من الحوامض الاريلية المستخدمة كادوية مضادة للالتهابات غير استيرويدية (NSAID) ولغرض التقليل من التاثيرات الجانبية السلبية للاسبرين والايبوبروفين من خلال ازالة التاثير السام لمجاميع الكاربوكسيل الحرة المرتبطة بهما، هدفت الدراسة ا | Aspirin and ibuprofen are aryl acids of (NSAID) with good analgesic , anti - inflammatory. For reducing the gastrointestinal toxicity accociated with Aspirin and Ibuprofen therefor the present work is aimed to synthesized a novel ester prodrugs of these two drugs, 1,2 : 5,6 - Di - O - isopropylidine - ? - D - glucofuranose is used a carrier alcohol for attachment of non - steroidal anti - inflammatory Drugs (Aspirin and Ibuprofen ).This work was accomplished according to the following steps.1 - Aspirin and Ibuprofen acid chlorides(1,2) were prepared through the reaction of the corresponding acid with thionyl chloride.2 - 1,2 : 5,6 - Di - O - isopropylidine - ? - D - glucofuranose is afforded by reaction D - Glucose with acetone and Lewis acid catalyst.3 - Esterification reaction of 3 - OH group in compound [AA] with compounds (1) and (2) yielded the corresponding Aspirin ester and Ibuprofen ester prodrugs [AB] and [AC].4 - Deacetonation of Compound [AB]. Using 70% acetic acid afforded Compound [AD].5 - The purity of the compounds synthesized was established by (TLC) and column chromatography.While the structures of their mutual prodrug was confirmed by (FTIR, H1NMR,C13NMR) and the result obtained given good evidence for structures proposed to their compounds.6 - Using through the study 36 rabbit, proximate in the weight and divided in to six groups. First group (six rabbit) control group did not have any dose, second group have (DMSO) dose ,third group have the Aspirin dose, fourth group have the Ibuprofen dose , Fifth group have the compound (AD) and sixth group have the compound (AC), After two hours withdrawal sample of blood from each rabbit, separated the serum to use in the biochemical study to the parameter at the following : The measured parameters include : enzymes activity (Lactate dehydrogenase(LDH) , Acid phosphatase, creatinkinase (MB) , Alkaline phosphatase(ALP) , Gloutamate - pyrovate transaminase (GPT) , Glutamate - oxaloacetate transaminase (GOT) , cholinesterase , peroxidase) , and measured concentration of (Glutathione , malonldialdehdy ,creatinine , albumin , total protein , globulin , uric acid ) and some element’s (Mg ,Fe ,Cu ,Zn). Statistical data analysis revealed signification increase in the levels of creatinkinase activity (147.130±16.176) U/I،(157.785 ±21.590)U/I)، 146.995 ±29.314) U/I by effect Ibuprofen (D), compound (AD), compound (AC) a succession. and alkaline phosphatase (121.933±13.061) U/I، (129.158±17.052)U/I by effect compound (AD), compound (AC) a succession.And Gloutamate - pyrovate transaminase (30.521 ± 6.365)U/I، (31.387 ± 3.005)U/I،(26.863±7.470)U/I، (22.973±6.052)U/I by effect Aspirin (C) ,Ibuprofen (D), compound (AD), compound (AC) a succession. And Glutamate - oxaloacetate transaminase (72.731 ± 5.533) U/I، (75.366 ± 5.032)U/I، (77.560 ± 6.681)U/I by effect Ibuprofen (D), compound (AD), compound (AC) a succession. and peroxidase enzyme(26.433±7.722) U/I، (29.500±3.555)U/I، 31.150 ±4.932)U/I by effect Ibuprofen (D), compound (AD), compound (AC) a succession. And signification increase in the concentration of glutathione (4.897 ±0.448) µmol/L، (4.957 ± 0.501)µmol/L، (4.771 ± 0.366)µmol/L by effect Ibuprofen (D) , compound (AD), compound (AC) a succession. And signification increase in the concentration of malonldialdehyde(11.507±1.841) µmol/L،(12.744±2.275)µmol/L، (14.240±2.861)µmol/L، (14.409 ±1.712)µmol/L by effect Aspirin (C) ,Ibuprofen (D), compound (AD), compound (AC) a succession. And signification increase in the concentration of creatinine (138.847 ± 16.116)µmol/L، (153.021 ± 14.307) µmol/L، (162.466 ± 19.269) µmol/L and (156.074±19.99) µmol/L by effect Aspirin (C) ,Ibuprofen (D), compound (AD), compound (AC) a succession. And signification increase in the concentration of uric acid (108.994 ± 17.347) µmol/L، (90.972 ± 17.567) µmol/L، (101.322±18.090) µmol/L، (101.990±22.918)µmol/L by effect Aspirin (C) ,Ibuprofen (D), compound (AD), compound (AC) a succession (All compared with the serum levels of the control group.The study also showed a signification decrease in level of cholinesterase activity (3140.43±295.54) U/I، (2964.57±351.77)U/I، (2708.40 ±348.29)U/I، (2748.90±464.21)U/I by effect Aspirin (C) ,Ibuprofen (D), compound (AD), compound (AC) a succession.The study also showed a signification increase in level of Total protein by effect compound (AD) ,(AC) (64.821±3.116)g/Land (64.228±5.733)g/La succession.Results had also confirmed a presence of signification increase in the concentration of Mg (0.953±0.147) mmol/L by effect compound (AC). and signification increase in the concentration of Cu (23.964±2.043) µmol/L، (24.740±1.449)µmol/L، (25.367±1.656) µmol/L، 25.003±2.008) µmol/L by effect Aspirin (C) ,Ibuprofen (D), compound (AD), compound (AC) a succession, compared with the serum levels of the control group. The study also showed a signification decrease in concentration of Zn (13.810±0.904) µmol/L،(16.112 ± 1.565) µmol/L،(12.025 ± 1.306) µmol/L، 11.654 ± 2.194) µmol/L by effect Aspirin (C) ,Ibuprofen (D), compound (AD), compound (AC) a succession, compared with the serum levels of the control group.The study also showed non - signification decrease in the activity of Lactate dehydrogenase, acid phosphatase. and non - signification increase in the levels Albumin , Globulin and Iron. And no effect on the level Mg. compared with the serum levels of the control group.7 - To ensure the release of parent drugs (Aspirin, Ibuprofen) a hydrolytic studies of the ester prodrugs [AD],[AC] were done at different pH [ 2 , 4 , 10 ,12 ] and at constant temperature (25 C0) ,The results should that the hydrolysis at basic pH were faster than acidic pH then it mean that the most hydrolysis will obtain at intestine not at stomach.

تقدير بعض الاحماض الامينية بطريقة الحقن الجرياني - البريق الكيميائي == Quantification of Some Amino Acids By Flow Injection - Chemiluminescence Technique

اسم المؤلف: نشوان حسين علي سليمان الجبوري
اسم المشرف: سهام توفيق امين | نزار احمد ناجي
الموضوع العام: علوم الكيمياء
السنة: 2013
الموضوع الدقيق: الكيمياء التحليلية
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: شمل الفصل الاول مراجعة عامة تضمنت الاحماض الامينية، الخواص الكيميائية والفيزيائية للاحماض الامينية. كما تضمن الفصل الطرائق المستخدمة لتقدير (السستائين, السستين,الهستدين) بتقنياتها المختلفة، كما تم التطرق للبريق ولانواعه، والظروف الاساسية لحدوثه في الاطوار | This thesis are in four chapters : Chapter I : General survey for amino acids, and their chemical and physical properties. it also includes the methods used for the determination of (cysteine,cystine,histidine) with different techniques. This chapter covers different chemiluminescence types and the necessary conditions to happen in different phases (liquid, gases and solids). The chapter also includes the analytical application for chemiluminesccence reaction with luminol as regarded the donor molecules; also other molecules that has been used for determination of chemiluminesccence and was addressed Flow injection analysis, and application, Chapter I ended with the aim of the project.Chapter II : Includes the preparation of the major chemical reaction solutions that are required for this research work, and also many other solutions that were needed as stook solutions for the many detailed study that were conducted through this research work. The primary study system innovation (Electronic - chemical optical) for the measurement of chemiluminescne.Chapter III : It is three sections : Section A : Involves the study assessment of cysteine through all chemical variables for all involved chemicals in the reaction, ,also various physical parameters were studied,the optimum condition for the determination of system , based on the system chemiluminescence (luminol - hydrogen peroxide - cysteine), the concentration of cysteine over range of (5 - 110) µg.mL - 1.The limit of detection was 9×10 - 6 mol.L - 1. ,RSD % for five replicates of a standard (4.9×10 - 4) was 0.8%.Section B : The optimum condition for the determination of cystine , based on system chemiluminescence (luminol - hydrogen peroxide - Cu II - cystine), calibration was linear between (20 - 80) µg.mL - 1for cystine.The limit of detection was (1.6×10 - 6) mol.L - 1 ,RSD % for five replicates of a standard(2.08 x10 - 4) was 0.94 %. Section C : The optimum conditions the determination of histidine , based on the system chemiluminescence for (luminol - hydrogen peroxide - Mn II - Histidine), calibration was linear between (10 - 160) µg.mL - 1for histidine.The limit of detection was (9.2×10 - 6)mol.L - 1.RSD % for five replicates of standard (5.1 × 10 - 4) mol.L - 1 was 1.27%.All the proposed methods have been applied successfully for the determination of amino acids in pharmaceutical. Moreover, the accuracy and validity of those methods were evaluated against pharmacopoeia method using F and t - tests. It was found that experimental F and t values at 95% confidence level did not exceed the critical values indicating that the present proposed methods have a good accuracy and validity.Chapter IV : Deals with inferences and recommendations

تقدير الكميات الضئيلة من الخارصين (II) والنحاس (II) والنيكل (II) باستعمال الكاشف الجديد انتي بايرايل ازو (2,7) - نفثالين دايول بالطرق الطيفية == Determination of Trace Amounts of Zinc (II) , Copper (II) And Nickel (II) Using New Reagent of Antipyriyl Azo(2,7) - Naphthalindiol By Spectrophotometric Methods

اسم المؤلف: مسار علي عواد عناد الزيادي
اسم المشرف: حسين جاسم محمد
الموضوع العام: علوم الكيمياء
السنة: 2013
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة الكوفة - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: النجف
الصفحات الاولى:
المستخلص: تم في هذه الدراسة تفاعل الكاشف المحضر الجديد 1 - ('4 - انتي بايرايل ا?زو ) 2,7 - نفثالين دايول(1 - APANDOL) مع (11) ايون فلزي مع استحداث طريقة طيفية لتقدير كل من ايونات الخارصين (II) ,والنحاس (II) ,والنيكل (II) بهذا الكاشف اذ كان الطول الموجي للامتصاص الا | The research includes primary study of the reaction of 1 - ( '4 - anti pyriyl azo) 2,7 - naphthalindiol (1 - APANDOL) with (11) metal ions ,and development of Spectrophtometric method for the determination of Zinc (II) ,Copper (II) and Nickel (II)with this reagent. The wavelength of maximum absorption for the reagent was found at (453) nm and for the complexes formed between these ion with this reagent was found at (492,499,514) nm for Zinc (II), Copper(II) and Nickel (II), respectively in aqueous medium ,also the optimum conditions for the reaction of these ion with the reagent were employed ,such as the volume of reagent solution ,time ,temperature, order of addition and effectives of pH, The calibration curves of these complexes were constructed ,Beer,s law was obeyed in the range of (0.1 - 2.5) ppm for zinc (II) with a correlation coefficient of ( r =0.9976) and molar absorptivity( ? =1.3x104) L.mol - 1.cm - 1 and sandell sensitivity was (0.0049) ?g.cm - 2. For copper (II) the rang was (0.1 - 2.5) ppm with a correlation coefficient of (r =0.9979) molar absorptivity (? =1.9x104) L.mol - 1.cm - 1, and sandell sensitivity was (0.0032) ?g.cm - 2 , as for nickel (II), the range was (0.1 - 2.0) ppm with acorrlation coefficient (r =0.9962) and molar absorptivity (? =2.0x104) L.mol - 1.cm - 1 and sandell sensitivity was ( 0.0029) ?g.cm - 2 The stoichiometry of the formed soluble complexes among Zinc (II), Copper (II) and Nickel (II) with reagent was investigated by both the continuous variations method and mole ratio method ,the ratio (M : L) was (1 : 2) for complexes at pH(8,8 and 9) respectively.The stability constant (Kst) for the complexes were equal to (Kst = (Kst =0.29 x108L.mol - 1) (Kst =1.6 x1010L.mol - 1) and (0.128 x108L.mol - 1) for Zinc ,Copper and Nickel respectively. Precision and accuracy of the analytical procedure were showed for (0.5) ppm of Zinc(II) , Copper(II) and Nickel (II) that R.S.D% was equal to (1.41 , 0.77 and 0.63 %) and Erel % was found to be (0.53% ,0.65% and 0.95%) for these ions , respectively. the analytical procedure were showed for (1.0) ppm of Zinc(II), Copper(II) and Nickel (II) that R.S.D% was equal to (0.58, 0.36 and 0.4 %) and Erel % was found to be (0.28%,0.30% and 0.99%) for these ions , respectively.The interference of metal ions in the presence of related ions was determined , as well as masking of these ions by suitable masking agents was studied. The physical properties of precipitants were studied through the establishment of melting point, solubility and molar conductivity as well as the measurement of infrared spectra ,with the suggestion of structural formula of the formed complexes with the reagent (1 - APANDOL). The method was applied for the determination of the content of Zinc(II), Copper (II) and Nickel (II), in tea leaves.. Finally ,The biological activity of these complexes was tested with two types of bacteria.

تحضير عدد من مشتقات الادوية الجديدة لحامض الاسكوربيك وسكر الرايبوز وقياس تاثير هذه المركبات على فعالية انزيم اللايبيز والكولين استريز == Preparation A Number of New Drug From The Derivatives From Ascorbic Acid And Ribose And Study The Effect of These Compounds on The Activity of Lipase And Cholinesterase

اسم المؤلف: محمد يونس حمادي حسين
اسم المشرف: نزار احمد ناجي | فراس طاهر ماهر
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: الكيمياء الحياتية
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: In this study, the preparation of a number of new drugs from the derivatives of ascorbic acid (vitamin C) and ribose have been done through the formation of esters of these compounds. The tetra - acid esters of ribose have been obtained with mefenamic acid and methyldopa and aspirin during treatment of mefenamic acid, methyldopa and aspirin chlorides with ribose. The tetra - ester of ascorbic acid with ampicillin has also been obtained through the reaction of ampicillin chloride with ascorbic acid. The Products have been diagnosed by infrared spectroscopy (IR).The effect of four products has been studied on lipase activity compared with metronidazole benzoate as ester on lipase activity. The results showed that the highest activity of the enzyme was when tetra aspirin ester of ribose was used (2.36 Cherry - Crandall’s unit) and the lowest activity (1.37 Cherry - Crandall’s unit) when using tetra ampicillin ascorbic acid ester. Other compounds showed a slight increase in lipase activity.The effect of four compounds have been studied on cholinesterase activity, the results showed that tetra ampicillin ester is the highest effect to increase cholinesterase activity

دراسة طيفية وثرموديناميكية لعدد من معقدات انتقال الشحنة المشتقة من تفاعل 3 - ميثوكسي - 4 - هيدروكسي بنزلديهايد وعدد من الامينات الاروماتية مع عدد من المستقبلات الالكترونية == Spectral And Thermodynamic Studies for A Number of Charge Transfer Complexes Derived From The Reaction of 3 - Methoxy - 4 - Hydroxy Benzaldehyde And Number of Aromatic Amine With A Number of Electron Acceptors

اسم المؤلف: اماني اياد حسين علي
اسم المشرف: عبد الرحمن خضير عبد الحسين الطائي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: الجزء الاول : وفيه تم تحضير تسعة من قواعد شف المشتقة من 3 - ميثوكسي - 4 هيدروكسي بنزلديهايد وعدد من الامينات الاروماتية متمثلة بالانيلين والانيلين المعوض ب ( 2 - هيدروكسي، 4 - هيدروكسي، 2 - امينو، 4 - امينو، 2 - كربوكسي، 4 - كربوكسي، 2 - نيترو، 4 | This work divided into three parts which is dealt with study of charge transfer complexes. Nine Schiff bases used in this work were prepared by mixing (1 : 1) mole 3 - methoxy 4 - hydroxy benzyldehyde and the corresponding aromatic amines (aniline ,2_hydroxy aniline , 4_hydroxy aniline , 2_amino aniline , 4_amino aniline ,2_carboxy aniline , 4_carboxy aniline , 2_nitro aniline , 4_nitro aniline).The electronic spectra in absolute ethanol solvent were used to study the intermolecular charge - transfer complexes between the considered Schiff bases as charge donor and five charge accepter molecules.Three of them are non - acidic acceptors such as (dinitro benzene DNB , Trinitro benzene TNB and Iodine I2 ) , another two are weak - acidic acceptors (Trinitro phenol TNP and p - nitro phenol p - NP ).The equilibrium constant of the CT complexes have been calculated by applying the Benesi - Hildebrands equation for (1x10 - 4 : 1x10 - 5 M) Schiff base : Acceptors concentration ratio. The equilibrium constants for complexes formation which are ranging between (1250 - 3000 mol - 1. dm3) with Iodine, (800 - 6000 mol - 1. dm3) with dinitro benzene, (833 - 4500 mol - 1. dm3 ) with trinitro benzene, (1000 - 5555 mol - 1. dm3 ) with para nitro phenol, (1000 - 6250 mol - 1. dm3) with Trinitro phenol ,The extinction coefficients have been determined were (3333 - 25000 L.mol - 1.cm - 1) with Iodine, (3333 - 25000 L.mol - 1.cm - 1) with DNB, (1111 - 20000 L.mol - 1.cm - 1) with TNB, (1111 - 20000 L. mol - 1.cm - 1) with p - NP , (2000 - 33333 L.mol - 1.cm - 1) with TNP.The ionization potential (Ip) of these bases also have been determined and are (6.02 - 8.90 e.V) with Iodine ,(11.6 - 14.15 e.V ) with Dinitro benzene (8.10 - 9.20 e.V) with trinitro benzene , (8.57 - 9.64 e.V) with Para nitro phenol ,(6.26 - 8.15 e.V) with Trinitro phenol for the Schiff base association constant , It way noticed that the values of all the physical parameters of CTC and Schiff bases are affected by the substituted group due to the increases or decreases in the stability of the carbonium ion character of the azomethane.The another part of this work deals with study of the effect of temperature on the value of equilibrium constant KCT in the range (298 - 318)0k for charge - transfer complex formations in addition the values of ?H , ?G0 and ?S0 of the CT complexes were calculated from the dependence of KCT upon the temperature , The negative values of the enthalpy which proves that the formation of CTC are exothermic and could occur spontaneously.Finally , the third part of this work deals with studying the kinetic of formation and decomposition of the CTC in ethanol.The results indicated , the more stable CTC decomposes slower whatever was the nature of the acceptors , and the rate constant for formations and decompositions followed first order.

تقدير الخصائص الفيزيائية والكيميائية لمياه الابار المحلية بوساطة تقنيات تحليلية مختلفة لتحديد نوعيتها وصلاحيتها للاستخدام البشري والزراعي == Determination of Physical And Chemical Characteristics of Local Wells Water By Using Different Analytical Techniques For The Establishing Their Quality Specifications And Usage Conformity

اسم المؤلف: احسان نصيف جاسم العبيدي
اسم المشرف: كريم ديمة خلف | كاميران حسين شكر
الموضوع العام: علوم الكيمياء
السنة: 2008
الموضوع الدقيق: الكيمياء التحليلية
الدرجة: ماجستير
الجامعة: جامعة بغداد - كلية العلوم للبنات
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: مؤخرا، ازدادت ظاهرة حفر الابار في المنازل والمناطق المحلية خصوصا بعد الحرب على العراق عام 2003 تبعا لشحة تجهيز الماء الصالح للشرب من قبل السلطات المسؤولة. هدف البحث اساسا لتعرف نوعية مياه الابار المحلية ومدى صلاحيتها للاستهلاك البشري والمنزلي، با | Recently , the phenomenon of drilling wells in the local areas and housings has increased before the war on Iraq 2003 due to the anticipations of insufficient supply of drinking water by the competent authorities. This research work is aimed to recognize the quality of the local wells water quality and the extent of their adequacy for human and domestic consumption. In addition to try to know the relevance of these wells water and the nearest point of surface water (i.e. river water). In this study , five wells were selected in Al - Adheem Embankment area and the surface water of Al - Adheem River itself. The sampling strategy of the two type of water began in 1/3/2007 and the process of sampling is complied with guidelines cited by national and international specifications , This piece of study involves four chapters. Chapter one deals with chemical literature review concerning environment and pollution , sources of groundwater pollution in addition to the physical and chemical characteristics of water such as color turbidity , electrical conductivity , TDS , TSS , pH , total hardness, Ca2+ , Mg2+ , Cl - , SO42 - , NO3 - , NO2 - and heavy metals contaminates (Cu2+ , Cd2+ , Ni2+ , pb2+ , Zn2+). Chapter two describes all methodology and techniques used in this study such as atomic absorption spectrometry (both FAAS and ETAAS) , UV - Vis spectrophotometry , pH - meter , conductivity meter , and sampling protocol according to those cited by national and international bodies. In addition to , the all procedures for measuring the constituents and characteristics of water samples were described. In chapter three , the outcome of this research work were reviewed and discussed for each constituent as mentioned above. The results of study are summarized in the table hereafter : Chapter four explicates the conclusions that attained by this research work showing the important study accomplished for the first time in this area of Iraq in one hand. In the other hand , it showed that some characteristics agree and disagree with the specifications of drinking water that are listed by Iraqi and other international bodies. Finally , It concluded that all water recourse selected in this work were not drinkable and improper for human consumption according to national and international specifications , but it could be useful for arable particularly for that plants stand high concentrations of salts.

تطوير طرائق طيفية لتقدير السلفاميثوكسازول والسلفاديازين باستخدام تفاعل الاقتران الازوتي == Development of Spectrophotometric Method For The Determination of Sulphamethoxazole And Sulphadiazine Using Diazotization Coupling

اسم المؤلف: امل حسين محيميد حسين
اسم المشرف: سعدية احمد ظاهر
الموضوع العام: علوم الكيمياء
السنة: 2011
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد - كلية العلوم للبنات
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اشتملت هذه الرسالة على ثلاثة فصول : يتضمن الفصل الاول استعراضا موجزا لاملاح الديازونيوم والكاشف الثايمول واهمية ادوية السلفا فضلا عن بعض الطرائق الحديثة في تقدير ادوية السلفا والهدف من اجراء البحث.واشتمل الفصل الثاني على وصف طريقة طيفية بسيطة وحساسة | his thesis consists of three chapters : - the first chapter includes a short notes on the diazonium salt and thymol reagent demonstrates a brief review for, an assay of sulpha drugs and aim of the work.The second chapter describe a simple sensitive spectrophotometric method for the determination of microgram amounts of sulphamethoxazole in aqueous solution, based on the coupling of diazotized sulphamethoxazole with thymol reagent in alkaline medium to produce an intense yellow coloured ,water - soluble and stable azo - dye which exhibits maximum absorption at 473 nm. The determination limits of Beer’s law were 1 - 6 µg.ml - 1, with a molar absorptivity 2.1 × 104 l.mol - 1.cm - 1. The average recovery was 100.12 %, and RSD 0.492 %, the LOD is 0.0087 ?g.ml - 1 and LOQ is 0.029 ?g.ml - 1. The method has been successfully applied for the determination of sulphamethoxazole in pharmaceutical preparations where the analytical results are compatible with certified value of pharmaceutical preparations and with a standard addition procedure.The third chapter demonstrates the development of simple sensitive spectrophotometric method for the determination of microgram amounts 1 - 7 µg.ml - 1 of sulphadiazine , based on the formation of diazotized sulphadiazine by adding sodium nitrite in acidic medium; followed by removing the excess of nitrite by sulphamic acid, the formed diazotized sulphadiazine was then coupled with thymol in strong alkaline medium to get a yellow coloured azo dye. The produced dye is stable and soluble in aqueous medium and it has maximum absorption at a wave length of 469 nm. The molar absorptivity was 2.6 × 104 l.mol - 1.cm - 1 with LOD and LOQ 0.0077 and 0.025µg.ml - 1 respectively. The method had good accuracy and precision; The average recovery was 100.57 % and RSD 0.657 %. The method was applied on the pharmaceutical preparation of sulphadiazine (as cream), the analytical results were in agreement with certified value of pharmaceutical preparation and with a standard addition procedure.

تحضير وتشخيص ليكاندات ازو جديدة ومعقداتها ودراسة تطبيقاتها الصناعية والبكتيرية == Synthesis And Characterization of New Azo Ligands And Their Complexes And Studying Their Industrial And Bacteriological Application

اسم المؤلف: زينب سلمان كاظم
اسم المشرف: عامر جبار جراد
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تتضمن هذه الدراسة تحضير ثلاثة ليكاندات ازو جديدة (L3 - L1) ارتكزت جميعها على 2،4 - ثنائي مثيل فينول، تمتلك الصيغ التركيبية الاتية : - شخصت الليكاندات المحضرة باستخدام (FTIR, UV - Vis, 1HNMR) والتحليل الكمي الدقيق للعناصرC.H.N) )، فضلا عن درجات الانصهار. | Three new azo compounds (ligands) L1 - L3 have been prepared all rest on the 2,4 - dimethylphenol as a back - bone of the prepared ligands having the following structures.The prepared ligands were characterized by melting points measurements, IR, 1HNMR and UV - Vis spectra and (C.H.N) analysis. The other part of this project refer to the synthesis of complexes of the ions Ni(II) and Cu(II) with all prepared ligands.All preparation was performed after fixing the ideal pH and molar concentration that obeyed Lambert - Beer’s law in the studied pH ranges. The structure of these complexes was deduced according to the molar ratio and Job methods depending on the spectroscopic studies of the complex solution of the above ions. However, ration of 1 : 2 M : L for all ions were obtained.The prepared complexes were characterized using IR and Uv - Vis spectra conductivity magnetic susceptibility and melting points measurements. The percentage of the metals in the complexes has been found by flameless atomic absorption technique. Micro elemental analysis (C.H.N.) were also measured, the results are in agreement with the calculated values. All the complexes are quite stable and could be stored for months without any appreciable change. According to the results obtained by elemental and spectral analysis, an octahedral structure was suggested for the prepared complexes with the ligand (L1) and mixed ligands (L1,L3)while tetrahedral for the all prepared complexes with the ligand (L2) and ligand (L3).In addition the dyeing performance of the prepared compounds was assessed. The dyes were tested for light and detergent fastness. Study of biological activities of the prepared compounds has also been performed. The study was carried out using Escherichia Coli, Staphylococcus aurous and Bacillus cereus in agar medium. Some of the complexes exhibit good bacterial activities.

تقنية استخلاص نقطة الغيمة لفصل واغناء المغنيسيوم (II) والخارصين (II) والنيكل (II) على هيئة ايونات سالبة وتقديرها طيفيا في نماذج بيئية وحياتية مختلفة == Cloud Point Extraction Method For Separation And Preconcentration of Mg 2+,Zn 2+,Ni 2+as Anions And Their Spectrophotometric Determination In Environmental And Vital Samples

اسم المؤلف: اباء عدنان عزوز المحنه
اسم المشرف: شوكت كاظم جواد
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة الكوفة - كلية التربية للبنات - قسم الكيمياء
اللغة: العربية
مكان الجامعة: النجف
الصفحات الاولى:
المستخلص: قد استعملت تقنية CPEعلى مدى واسع من التطبيقات في اغناء وفصل واستخلاص العديد من المركبات البايلوجية والدوائية والمركبات العضوية والعديد من الايونات الفلزية على هيئة معقدات سالبة اوموجبة في محاليلها المائية.وتعد من التقنيات المهمة والسهلة والرخيصة والصديقة | Cloud point extraction CPE methodology is wide spread used for applications to separation or Preconcentration and extraction of many medic mental or biological compounds as well as organic compounds and several metal ions as negative or positive and neutral complexes for aqueous solutions, as well as this method considers an easy, cheap and important technique and one application of green chemistry with high sensitivity which isn’t use organic solvents. This study is an application for CPE methodology for extraction, separation and preconcentration of magnesium (II), zinc (II) and nickel (II) from aqueous solutions as anions coupled with spectrophotometric method for determination these metals in different vital and environmental samples. And the major thought of this study is to change the metal ion to anion complex in aqueous solutions, and then extracted as ion pair association complexes after combination with large suitable complexing agent and using surfactant as additional phase to extract ion pair association complexes formed and in this study surfactant TritonX - 100 was used. This study include extraction of Mg (II) as anion complex with Oxine [Mg (OX3) - ] after combination Mg2+with Oxine produced from 8 - hydroxy qunoline in basic solution NaOH, afterward formed ion pair association complex with Rhodamin - B.The first step in this study is the definition (?max ) for ion pair association complex formed and extracted spectrophotometricaly. The study show ?max was 648 nm according to mechanism below : Mg2+ + 3 OX - Mg (OX) 3 - Rhb+; Cl - + Mg (OX) 3 - [Rhb+; Mg (OX) 3 - ] + Cl Cloud point extraction CPE method is one of indirect method of extraction to submit to thermodynamic equilibria which is control extraction method.This study demonstrate (50µg/10 mL) giving best extraction with higher activity as well as this method need 0.08 M 8 - HQ for extraction, as well as 0.5 M NaOH to produce Oxine from 8 - HQ as well as need 1×10 - 4 M Rhodamine - B for favorable activity of extraction. Extraction of zinc (II) according to CPE method, by using PANN as new complexing agent prepared in this study to produce ion pair association complex in HCl media after change Zn2+ to ZnCl3 - , ZnCl4= , spectrophotometricaly show ?max = 414 nm for ion pair association complex formed and extracted. According to equilibria below : PANN + 2 HCl [2H - PANN] 2+; 2Cl - PANN + HCl HPANN+; Cl - Zn2+ +3 HCl - ZnCl3 - + 3H+ Zn2+ + 4 HCl ZnCl4= or HZnCl4 - + 3H+ or 4H+ HPANN+; Cl - + ZnCl3 - HPANN+; ZnCl3 - + Cl - HPANN+; Cl - + HZnCl4 - HPANN+; HZnCl4 - + Cl - [2H - PANN] 2+; 2Cl - +ZnCl4= [2H - PANN] 2+; ZnCl4= +2Cl - Hydrochloric acid HCl media play a major rule for change metal cation Zn2+ into anion complex ZnCl3 - or ZnCl4= , then study demonstrate 1M was optimum concentration of HCl giving higher activity of extraction Zn2+ with (20µg/10 mL). Extraction of nickel (II) according to CPE method by used DB18C6 with mechanism of extraction below : Ni2+ + 3H+Cl - NiCl3 - + 3H+ Ni2+ + 4 H+Cl - NiCl4=+ 4H+ Na+Cl - + DB18C6 [NaDB18C6] +; Cl - [NaDB18C6]+; Cl - + NiCl3 - [NaDB18C6] +; NiCl3 - + Cl - [NaDB18C6]+; Cl - + HNiCl4 - [NaDB18C6] +; HNiCl4 - + Cl - Higher activity of extraction was by use of 0.5 M HCl, 0.25 M NaCl, Ni2+ (50µg/10 mL) as well 1×10 - 4 M DB18C6. With study the effect of crown ethers and cryptand kinds. Which include thermodynamic and applications for spectrophotometric determination of these metals in different samples.

تحضير وتشخيص انواع جديدة من الاطيان الهجينة بطريقة ادخال ايونات المعادن باستخدام اطيان السمكتايت العراقية == Preparation And Characterization of Anew Hybrid Clays By Intercalaion With Metal Ions Using Iraqi - Smectite Clays

اسم المؤلف: فرات لطيف يحيى شريف
اسم المشرف: محمد حسن عبد اللطيف
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The aim of this study is to prepare two types of hybrid Iraqi Clays, which have been magnetic Properties by using the mothed of Intercalation.In this study, we have used two types of Iraqi clays (Bentonite and Attapulgite) with a saturated solution of ferrous chloride aqueous (FeCl2.4H2O) , ferric chloride aqueous (FeCl3.6H2O) and Super Magnet solution (Nd2 Fe14 B), the clays activate firstly by using the way of the ionic exchange with industrial Ionic exchanger on the formula (H - Form) , then we intercalate different percentage of iron ions and Super Magnet to that clays.They have used different analytical techniques in this study which include : Magnetic Susceptibility ,Infrared spectroscopy , X - ray diffraction spectrum and Scanning Electron microscopy. the results were have obtained as follows : 1 - The activation process has led to removal the impurities and thus led to increase of the proportion each of Montmorillonite and Attapulgite metal.2 - Magnetic Susceptibility of Initiated Clays are higher than the Magnetic Susceptibility of crude clays.3 - Magnetic Susceptibility increases due to intercalate two types of iron ions, as well as intercalated Super Magnet and has models depended in Table (3 - 2) as the higher models of Magnetic Susceptibility with bentonite clay and models in Table (3 - 13) are higher models of Magnetic Susceptibility with Attapulgite clay, 'the model number (1) is the highest Magnetic Susceptibility models of Super Magnet with clay bentonite, either Attapulgite clay has increased Magnetic Susceptibility by using all ratios in Table (3 - 27).4 - Infrared spectrum has showed appearance of clear peaks back to Hematite and Magnetite which have two types of iron oxides, which own magnetic properties and the peaks have notpresented in the spectrum of the raw clay for each of bentonite and Attapulgite as well as appearance of new peak back to hydroxide neodymium at intercalated the Super Magnet.5 - Powder X - ray diffraction spectrum has Showed an increasing in the intensity of each of the Montmorillonite and Attapulgite metal after activation process' After intercalation process we note a decrease in the intensity of Montmorillonite and Attapulgite metal because of the entry of different ratios of iron ions As well as (Nd2 Fe14 B) This is evidence formation of hybrid clays where the X - ray spectrum showed appearance of new peaks back to Hematite , Magnetite and Super Magnet, as well as an increase in the intensity peaks of Hematite in the original clay.6 - Scanning Electron microscopy image has shown on a clear change in the crystalline structures that have appeared on the surface of clay which show the success of intercalation process.Through the results we have obtained through this study that the method used in Activation of clay and intercalation of two type of iron as well as a Super Magnet is a successful method and can be depended in the preparation of Clays possess magnetic qualities can be used in high - efficiency adsorption and ion exchange applications.

طريقة مطورة لتقدير عقاري هيدروكلوريد البايريدوكسين واللايسينوبريل ببناء اقطاب بوليمرية انتقائية غشائية وبالطرائق الطيفية == Development Method for Determination of Pyridoxine Hydrochloride And Lisinopril Dihydrate Drugs By Construction of Selective Membrane Polymer Electrodes And Spectrophotometric Methods

اسم المؤلف: فدعم متعب عبدون حمد الجبوري
اسم المشرف: سهام توفيق امين
الموضوع العام: علوم الكيمياء
السنة: 2008
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: This study includes the determination of Pyridoxine Hydrochloride (PYR) and Lisinopril dihydrate (LIS) drugs by using Potentiometric and Spectrophotometric Analytical Methods.First : Potentiometric Methods : This method includes construction of membrane selective electrodes based on complexation of drugs with Phosphomolybdic acid (PM) and Phosphotungestic acid (PT) as an active materials and using Di - Butylphthalate (DBP) and Tri butyl phosphate (TBP) as a plasticizers , polyvinylchloride was used as a matrix for this electrodes.The Characters of each electrode were as follow : 1. For electrode PYR - PM using DBP as a plasticizer, the results were : 10 - 5 - 10 - 1, 52.4 mV/decade ,0.9969 , 2.37 x 10 - 7 M, 2.8 - 3.0 at 27oC for linear range, slope , correlation coefficient , limit of detection, optimum pH range respectively using internal filling solution of 10 - 3 M. The life time of the electrode was 23 days. 2. For electrode PYR - PT using DBP as a plasticizer, the results were : 10 - 5 - 10 - 1, 57.2 mV/decade ,0.9991 , 5.24 x 10 - 7 M, 2.5 - 2.7 at 25oC for linear range, slope , correlation coefficient , limit of detection, optimum pH range respectively using internal filling solution of 10 - 3 M. The life time of the electrode was 19 days.3. For electrode LIS - PM using DBP as a plasticizer, the results were : 10 - 5 - 10 - 1, 32.0 mV/decade ,0.9970 , 2.1 x 10 - 7 M, 3.6 - 3.9 at 27oC for linear range, slope , correlation coefficient , limit of detection, optimum pH range respectively using internal filling solution of 10 - 3 M. The life time of the electrode was 35 days.4. For electrode LIS - PM using TBP as a plasticizer, the results were : 10 - 5 - 10 - 1, 28.175 mV/decade ,0.9985 , 1.16 x 10 - 7 M, 3.2 - 3.5 at 25oC for linear range, slope , correlation coefficient , limit of detection, optimum pH range respectively using internal filling solution of 10 - 3 M. The life time of the electrode was 28 days.Second : Spectrophotometric Methods : 1. Oxidative Coupling : The drug PYR determined by oxidative with 1.8 ml of 0.1M Sodium periodate and 1.6 ml of the reagent 4AAP 0.05M , the absorption of the colored product is measured at 528 nm , for the range of concentration from 2.0 - 30 ?g.ml - 1.The molar absorptivity was 6126.88 l.mole - 1.cm - 1 and Sandel index 0.03356 ?g.cm - 2.2. Diazocoupling : The drug LIS determined by dizocoupling reaction , the drug react with excess nitrite in an acdic medium to produce the corresponding diazonium salt.After the removal of residual nitrate with sulphamic acid, the diazonium salt is coupled with the reagent 4AAP in basic medium to produce aso - dye an intense orange colored which exhibits maximum absorption at 453nm. Beer's law is obeyed over range from 40 - 320 ?g.ml - 1 with molar absorptivity was 1.0596×103 l.mole - 1.cm - 1 and Sandel index 0.416?g.cm - 2.

تحضير بعض بوليمرات قواعد شف ودراسة التشويب والتوصيلية الكهربائية لها == Synthesis And Characterization of Some Poly Schiff Base And Study Their Doping And Electrical Conductivity

اسم المؤلف: عمار فراس ابراهيم الدليمي
اسم المشرف: عماد طه بكر التكريتي | علي طه علي السامرائي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: يتناول البحث تحضير المونومير ثنائي الامين (M1) الناتج من تفاعل 4 - امينو اسيتو فينون مع التيرفثالدهايد بطريقة تحضير الجالكونات وكذلك تحضير سبع بوليمرات من نوع بولي قواعد شف اذ استعمل ثنائي الامين (M1) في تحضير البوليمر (I) من خلال عملية تكاثف مع التيرفثال | This research handles preparation of seven polymers of poly Schiff bases , and The di amin (M1) has been prepared from reaction of 4 - amino acetophenone with terphthaldehyde by Chalcons preparing method , where terphthaldehyde was used to prepare ( VI , V , VII ) polymers through condensation with di amines { 2,6 - di amino pyridine , 4 - amino phenyl sulfone , di amino malono nitrile } , also phtaldehyde was used to prepare ( VII , IV ) polymers by condensation with di amines ( 2,6 - diamino pyridine , 4 - amino phenyl sulfone ) , and isophthaldehyde was used in preparation of polymer (III) by condensation with { 2,6 - di amino pyridine } and below is the structure of the prepared di amine (M1). All polymers have been characterized by FT - IR technique , and some of them were characterized by CHN and 1H - NMR , Pellets preparing of all polymers where prepared with thickness range (0.97 - 0.75) with range pressure (1000 - 2000) Kg\cm2 , and then a Volume Electric doped Conductivity has been measured for the samples in their pure and doped state by using different dopants (Iodine , Ferric chloride , Zinc chloride , and p - toluene sulphonic acid) , with different mole percentage , and also The Iodine doping was carried out by vaporization tecnique , electrical conductivity of polymers have been found in pure state (fist polymer to seven polymer) as follows : ( 1.19 - 11 , 1.22E - 11 , 2,76E - 11 , 3.00E - 11 , 2.28 E - 11, 2.33E - 10 , 8.00E - 11 ) the highest value for conductivity was for polymer ( VI ) which reached 2.33E - 10 , while the highest conductivity for the doped polymers was by using dopant iodine and reach to 9.66E - 6. the effect of changing the substitution benzene and the effect of dopants on increasing conductivity of polymers where the most effective factors for increasing the conductivity.

تحضير مشتق جديد للبايروزولون ازو واستعماله في تقدير الكميات الضئيلة لبعض الايونات الفلزية بالطرائق الطيفية == Preparation of New Pyrozolone Azo Derivative And Use It For Micro Determination of Some Metal Ions By Spectrophotometric Methods

اسم المؤلف: شيماء حسن ملاح
اسم المشرف: حسين جاسم محمد
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تضمن البحث تحضير الكاشف الجديد 3 - (?4 - انتي بايرايل ازو) - 1 - نايتروزو - 2 - نفثول واجراء دراسة اولية مع (9) ايون فلزي واستحداث طريقة طيفية لتقدير كل من النحاس (II) والكوبلت (II) بهذا الكاشف في الوسط المائي، اذ كان الطول الموجي الاعظم للكاشف (374) نان | The research includes primary study of the reaction of 3 - (4? - Antipyriyl azo) - 1 - Nitroso - 2 - naphthol (APANN) with (9) metal ions and spectrophotometric method for the determination of copper (II) and Cobalt (II) ions with this reagent. The wavelength of maximum absorption (?max) for the reagent is (374) nm and for complexes formed between these ions with this reagent was found at (430.5) nm and (432) nm for both copper (II) and Cobalt (II( respectively in aqueous medium, also the optimum conditions for the reaction of these ions with the reagent were employed ,such as the volume of reagent solution, time, temperature, type of buffer, order of addition and effect of pH, calibration curves of these complexes were constructed. Beer's law was obeyed in the range (0.1 - 2.5) ppm of copper with a correlation coefficient (R2= 0.9971) and molar absorptivity ? = 1.83 × 104 L.mole - 1.cm - 1 and Sandell sensitivity was (0.00349) ?g.cm2 - , as for Cobalt, the range was (0.1 - 2.5) ppm with a correlation coefficient (R2= 0.9965) and molar absorptivity ? = ) 3.3×104 ( L.mol - 1.cm - 1 ,and Sandell sensitivity was (0.0018)µg.cm - 2. The stoichiometry of the formed soluble complexes between copper (II) and Cobalt(II) with reagent was investigated by both the continuous variations method and mole ratio method, the ratio (M : L) was (1 : 2) for Copper complex and Cobalt complex at pH (8.5) for both complexes. The stability constant (Ksta) for the complexes of copper (II) and Cobalt (II( was equal to (8.237 ×108 L.mol - 1) and (1× 108 L.mol - 1) respectively. Precision and accuracy of the analytical procedure were showed for (0.5) ppm of Cu (II) and Co (II) that R.S.D.% was equal to (0.97), (0.73) , (Erel, Re)% (0.6, 99.4)%, (0.4, 99.6)% for these ions, respectively. The analytical procedure were showed for (1) ppm of Cu (II) and Co (II) R.S.D.% was equal to (0.41,0.60) , (Erel, Re)% (0.3, 99.7)%,(0.2, 99.8)% for these ions respectively. The interference of metal ions in the presence of related ions was determined, as well as, masking of these ions by suitable masking agents was studied. The study of effect of three kinds of surfactants on the absorptions of the complexes and calculation of stability constants and treatment of the results statistically and make comparison with aqueous medium were done. The physical properties of precipitants were studied through the establishment of melting point, solubility and molar conductivity as well as the measurement of infrared spectra , and C.H.N, with the suggestion of structural formula of the formed complexes with the reagent (APANN). The method was applied for the determination of the content of copper (II) in tea leaves samples and Cobalt (II) in raw caw milk samples. Finally ,The biological activity of these complexes was tested with four types of bacteria.

تاثير بعض الادوية على بعض الانزيمات الناقلة لدى مرضى السكري النوع الثاني في محافظة بابل == Study Effect of Some Drugs On Some Transfer Enzymes In Diabetes Mellitus Type 2 In Babylon Province

اسم المؤلف: زينب غالب عبد الكريم الجبوري
اسم المشرف: عودة مزعل ياسر الزاملي
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: شملت الدراسة 100 مريضا بداء السكري من النوع الثاني )غير المعتمد على الانسولين( NIDDM، تراوحت اعمارهم بين ) 53 - 35 ( سنة وتم الحصول على النماذج من المرضى المراجعين الى مركز السكري في مدينة مرجان الطبية في محافظة بابل - العراق، بالاضافة الى 35 شخص ا اصحاء | This study involved 100 patients with Diabetes Mellitus type 2, with average of age between (35 - 63) years old. The patients were enrolled in the Diabetes Center in Merjan Medical City, in Babylon Province, Iraq at February 2014 to August 2014. In addition to 50 healthy persons who represent control group, and their age between (35 - 55) years old.The patients were divided into three groups as followingFirst : (28 patients were treated with Metformin (Glucophage) drug).Second : (30 patients were treated with Daonil (Glibeneclamide) drug).Third : (42 patients were treated with Metformin and Daonil).In addition to 50 healthy persons who are selected as control group (without chronic diseases or diabetic and without smoking).The Diabetes Mellitus type 2 was characterized as in WHO criteria which including that all patients in this study, (the patients who are not suffering from hypertension, the asthma, smoking, alcoholism and without using any other drugs over the essential diabetes drugs except that of (Metformin and Daonil) are dismissed in this study). Serum and whole blood were used to estimate the levels of fasting blood glucose, urea, creatinine, proteins, cholesterol, tri glyceride, fatty proteins (HDL - c, LDL - c and VLDL - c) and liver enzymes (ALT, AST and GGT) in the serum, HbA1c was detected in the whole blood. MDA and Glutathione in the erythrocytes. In this study, It was found that there are significant and insignificant differences for each of variables related to Diabetes for different types of drugs. Also, the glutathione S - transferase GST was purified from red blood cells (RBC) of control group by ionic exchange chromatography by means of DEAE Cellulose. After that, the electrophoresis of resulted enzyme was made to assess the molecular weight by using of Sodium Dodecyl Sulfate - Poly Acrylamide Gel2Electrophoresis (SDS - PAGE). The same process was done by using NAITIVIN apparatus to separate the enzyme quantified, and the resulted enzyme from NAITIVIN was treated with the drugs taken by patients. After that, the activity of GST enzyme was measured to show the different drugs effect upon the GST enzyme activity. For the purified enzyme activity after treating it with drugs was 3.62 , 3.57, 3.66 ?mol / min / ml , for each of Metformin, Daonil, and Metformin & Daonil respectively, while the activity of GST purified enzyme without treating with drugs was 3.24 ?mol / min / ml.Through this study, it has been noticed that there is an increasing of enzyme activity after purifying and mixing it with drugs, and this increasing results from the drugs effect upon GST activity, for the enzyme use to transform these poisons (drugs) and resulted compounds outside the body.

تحضير وتشخيص بوليمرات جديدة مقاومة لللهب ودراسة خواصها الحرارية == Synthesis And Characterization of New Flame Retardant Polymers And Study Their Thermal Properties

اسم المؤلف: محمود عودة مطشر
اسم المشرف: محمد علي مطر
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تستخدم البولي ايميدات الاروماتية على نطاق واسع في الصناعة لما لها من خصائص ممتازة في الثبات الحراري, الصلابة العالية ومقاومة اللهب, وهي واحدة من البوليمرات التجارية القوية جدا والعالية الاداء ولها استخدامات وتطبيقات واسعة في التكنلوجيا المتقدمة ,وتضمنت ال | Aromatic polyimides have been widely used in industry because of their excellent properties in thermal stability, high hardness and flame resistance. The present work involved preparation of new diamine monomers ( ABBB, ABAB, ABTB, ABDB, BPP, BCP, BDBP) containing (bromine, chlorine, phosphorus) as flame retardants and introducing them in reaction with different dianhydrides including )PMDA, BTDA, 6FDA) producing new aromatic polyimides (P1 - P7), as follows : - 1. preparation of aromatic diamine monomers containing bromine (ABAB and ABBB), and then introduced in reaction with dianhydride (PMDA) by solution polycondensation producing polymers (P1 and P2) respectively.2. preparation of aromatic diamine monomers which containing elemental (chlorine and bromine), a (ABDB, ABTB) and then reaction with dianhydride (BTDA and PMDA) respectively by solution polycondensation producing polymers (P3 and P4). 3. Preparation of aromatic diamine monomers which containing elemental phosphorus, (BDBP, BCP, BPP) and then their reaction with dianhydride (BTDA, 6FDA, BTDA) by solution polycondensation producing polymers (P5, P6, P7).The prepared monomers and polymers were characterized by (FT - IR and 1HNMR Spectra). The thermal stability of these aromatic polyimides were investigated by means of thermo gravimetric analysis (TGA) in a argon atmosphere and at a heating rate of 10°C/min at 800°C and by comparing them with aromatic polyimides (PIPM, PIBT, PI6F) empty elements flame retardant, where proven polymers (P1 - P7) stability of heat is very high, where temperatures were at loss (50%) by weight (T50%) more than (800oC) while the aromatic polyimides (PIPM, PIBT, PI6F) ranging between (492 - 582oC), and the percentage of remaining at a temperature of 800 o C for polymers( P1 - P7) ranging between (59 - 71%) on reverse polymers (PIPM, PIBT, PI6F), the percentage of remaining range (20 - 42%) , has been proven polymers (P1 - P7) high resistance to flame through the rate ratios (Char yield%) at a temperature of 500 o C where it was ranging between (86 - 99%), while for polymers (PIPM, PIBT, PI6F) ranging between (48 - 56%) at the same degree. and has been studying and evaluating the solubility of polymers prepared where appearance polymers (P1 - P7) solubility is very high, especially in solvents (polar aprotic) and because the process of modification in its chemical composition, where the presence of groups hydroxide and flexible ether linkages averse polymers (PIPM, PIBT, PI6F), which showed a lower solubility.

تخليق قواعد شف جديدة مشتقة من انهدريد البايرومليتك == Synthesis ,Antibacterial of Some Novel Schiff Bases Derived From Pyromellitic Dianhydride

اسم المؤلف: عذراء محمد سلوم
اسم المشرف: امينة عبد الرحمن فياض | عماد تقي علي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تم تخليق قواعد جديده مشتقة من انهدريد ثنائي البايرومليتك بعدة خطوات. حيث حضرت مشتقات حامض البايرومليتك المتناظره a­c[ I ] من تفاعل انهدريد ثنائي البايرومليتك مع بعض الامينا ت الاورماتية الحاويه على (مجاميع ساحبه واخرى دافعة ) في الاسيتون كمذيب. واشتملت | The novel Schiff bases derived from pyromellitic dianhydride were synthesized by several steps reaction. A symmetrical diamic acide [I ]a - c was synthesized by the reaction of pyromellitic dianhydride with some aromatic amines (containing electron withdrawing , repulling groups ) in dry acetone.In the second step the diacids were converted to their corresponding diimide [II ]a - c using acetic anhydride and sodium acetate system as a dehydrating agent, via the intramolecular cyclization steps of amic acids.The third step was to synthesis the hydrazone derivatives from the reaction of diimides , with 80 % hydrazine hydrate at (50 - 60)C?.These hydrazone derivatives were allowed to react with several aromatic aldehydes to form new Schiff bases via step four at a temperature near by (80 - 85)C?. As shown in the following scheme (3.1). All the novel compounds and their structures have been ascertained by their melting points , mixed melting points , C.H. N analysis , FTIR , UV - Viss. and 1HNMR spectroscopy for some of them. Also the biological activity of some of them was studied which showed that these compounds have different activities towards the studied bacteria.

تحضير وتشخيص ودراسة الفعالية البايولوجية لبعض مشتقات البريميدين الجديدة بتطبيق تفاعل سوزوكي == Synthesis And Characterization And Biological Activity Study of Some New Pyrimidine Derivatives Via Application Suzuki Reaction

اسم المؤلف: رؤى جميل كامل
اسم المشرف: نبيل عبد عبد الرضا
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء العضوية
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تضمنت الرسالة تحضير وتشخيص عدد من مشتقات البريميدين الجديدة من خلال تطبيق تفاعل سوزوكي، كما شملت الرسالة الفعالية البايولوجية للمركبات المحضرة ضد فيروس الايدز، تم انجاز موضوع الرسالة بتطبيق الاجزاء التالية : الجزء الاول تحضير المركبات 99 , 101 , 103 , 1 | The thesis included a detailed study of the biological importance of Pyrimidines compounds. The literature screening included the synthesis of different derivatives of pyrimidines compounds as well as their chemical reactivity , in addition to the experimental part which included the chemical procedures for preparation of the new derivatives of pyrimidine. New pyrimidine derivatives have been prepared by several parts : The first part include preparation of compounds 99 , 101 , 103 , 105 , 107 , 108 , 110 , 112 , 114 , 116 by Suzuki coupling reaction via reaction of uracil derivatived with the aromatic boronic acids to give new derivatives.The second part includes preparation of pyrimidine derived 117 by nitration of compound 42 using of concentrated nitric acid with concentrated sulfuric acid and preparation of new derivatives starting from compound 117 via Suzuki coupling reaction with some aromatic boronic acids.The third part includes includes preparation of new two compounds derived from compound 120 via Suzuki coupling reaction with the different boronic acides. The fourth part includes preparation of pyrimidine derivatives 126 by reaction of pyrimidine derivatives 120 with para - chloroaniline via coupling reaction to give the new derivative of azo pyrimdine dye.The fifth part includes preparation of new two compounds derived from compound 126 via Suzuki coupling reaction with the different boronic acides.As well as the thesis which us discussed the preparation and identification of new pyrimidine derivatives from throough spectra (I.R) , (1H - NMR) , (13C - NMR) and (C.H.N) and specta (HSQC) , (COSY) and (HMBC). For some of these compounds, and these identification studies approved the correctness of the chemical structures for the prepared derivatives. As well as in the thesis is included biological activity against AIDS. Scheme (1)R NO. R NO.4 - OH 96 4 - CHO 984 - OMe 109 4 - Cl 1004 - CN 111 4 - OEt 1024 - CF3 113 4 - OMe 1043,4 - OMe 115 4 - Br 106 (A) : (Ph3P)4Pd, Na2CO3, n - PrOH, Reflux(B) : NaNO2, HCl, (0 - 5)C°, 16h.

تحضير وتشخيص الليكاند 7 - ]2 - (بنزاميدازوليل) ازو [ - 8 - هيدروكسي كوينولين مع بعض ايونات العناصر الانتقالية ودراستها ضوئيا == Preparation And Identification of Ligand 7 - [2 - (Benz Imidazolyl)Azo] - 8 - Hydroxy Quinoline (BIAHQ) And With Some of Transition Elements Ions And Photo Study

اسم المؤلف: سؤدد عبد الباقر جابر
اسم المشرف: حسن عباس حبيب | خالد جواد العادلي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: لقد تضمنت هذه الرسالة تحضير نوع جديد من ليكاندات الازو العضوية غير المتجانسة حلقيا الحاوية على مجموعة ازو واحـدة وهو الليكاند 7 - ]2 - (بنزاميدازوليل ازو[ - 8 - هيدروكسي كوينولين(BIAHQ).وقد تم تشخيص هذا الليكاند بوساطة طيف الكتلة وبروتون طيف الرنين الن | This research included prepare a new ligand of azo organic heterocyclic ring containing one azo group which ligand 7 - [2 - (Benzimidazolyl azo) - 8 - hydroxy quinoline] (BIAHQ). Has been identification this ligand by mass spectrometry , proton nuclear magnetic resonance spectra ,infrared and UV - visible as well as analysis of the elements(C,H,N), included the preparation of four complexes of ligand (BIAHQ) with metal ions Co 2+ , Ni 2+,Cu 2+ and Zn2+ also studied the spectra of infrared spectra of the complexes prepared, and when compared with the spectra of the free ligand gave the obvious changes have shown these spectra a new peaks were not already present in the spectra ligand This is due to corrdenation between the metal ions under study with the atoms donor nitrogen group azo and nitrogen atom imidazole ring (N3) in the molecule of ligand, suffered with other peakes obvious changes in the shape, intensity and location, and an indication of this process for corrdenation between the metal ions under study and ligand, also studied the spectra of UV - visible, as well as a rigorous analysis of the elements (C,H,N) has been shown by the results agreat compatibility between the ratios calculated theoretically and practically of acquired. Through the results that have been reached suggested formulas compositional complexes showing through which that ligand azo imidazole mono - azo behave as ligand Triplalt coordenat through a nitrogen atom imidazole ring (N3),nitrogen group azo away from the ring heterogeneous and Oxygen of hydroxy quinoline group, which leads to the formation of complexes hexagonal symmetry. Studied the kinetics of photochemical dissociation of these complexes claw through irradiation solution single - wavelength light 365=? nm issued by the mercury lamp low pressure and at a temperature of 25 ?c and show that the interaction of dislocation is first order for all complexes. Was calculated photolysis rate constant kd mediated follow spectral changes during the process of irradiation. For access to the optimum conditions for the dissolution of these complexes have been studying the impact of several factors on the behavior of photochemical included : study the effect of the change in the intensity of light on the rate of disintegration and found that the increas in the intensity of the incident light increased the rate of disintegration of the complexes , as well as the study of the disintegration of the complexes in the temperature range 30 - 15?c found it increasing the temperature increases rate of disintegration. Values were calculated activation energy for all complexes , also studied the effect of the acidic function within the range of 9.3 and found that the rate of the disintegration of the four complexes increases with increasing pH solution. It was the study of the effect of the solvent polarity on the rate of disintegration using solvents ( methanol , ethanol,1 - butanol and isopropanol ) and found that the higher the rate of the disintegration of the complexes have been achieved in methanol , while lower rate was in isopropanol.Also thermal stability studied for ligand and complexes were submitted to thermal analysis (TGA and DSC) activation thermodynamic data are calculated and determainTg ,Tc , Tm and Td.

تحضير ودراسة طيفية وامتزاز لمعقدات بعض ايونات العناصر الانتقالية لليكندات المشتقة == Synthesis Spectroscopic And Adsorption Studies of Some Ions Transition Metal Complexes For Ligands Derived From Sulfamethoxazole And Its Mixed Ligands

اسم المؤلف: فرح علي داود
اسم المشرف: ساهرة صادق عبد الرزاق | احمد ثابت نعمان
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: ان الهدف من الدراسة هو تحضير وتشخيص ليكاند ثنائي السن : - [4 - (5,5 - dimethyl - 3 - oxocyclohex - 1 - enylamino) - N - (5 - methylisoxazol - 3 - yl)benzene sulfonamide]من تفاعل السلفاميثوكسازول مع الدايميدون لينتج الليكاند [H2L] باستخدام طريقة الصهر ا | The aim of the study is the preparation and characterization of bidentate Ligand [4 - (5,5 - dimethyl - 3 - oxocyclohex - 1 - enylamino) - N - (5 - methylisoxazol - 3 - yl) benzene sulfonamide]. The ligand was prepared by fusing sulfamethoxazole and dimedone at (170) ?C for half hour. The prepared ligand was characterized by FTIR,UV - Vis spectroscopy, H1,C3 - NMR spectra, mass spectra, molar conductivity measurement and melting point. The molecular structure for the ligand [H2L] which was proposed as drawn in the figure below : - Ligand [H2L]The complexes prepared using reflux in ethanol as solvent were two types namely : - 1 - Complexes of (1 : 1) mole ratio formula [M(H2L)(H2O)2]Cl22 - Complexes of (1 : 1 : 1) mole ratio formula [M(H2L)(HA)] in the presence of KOH as a base, Where : - M(II) = (Co ,Ni ,Cu) HA= 3 - amino phenol. Spectroscopic methods (FT - IR, UV - Vis spectroscopy) along with (A.A), chloride content and melting point were carried out in addition to molar conductance were done for the characterization of all complexes.The proposed tetrahedral geometry around the metal ions studied were concluded from these measurements. [M(H2L)(H2O)2]Cl2 [M(H2L)(HA)]Molar ratio method were used to determine M to L ratio at maximum wave length (?max=455nm ).The ratio were (1 : 1) mole for both complexes (1) and (4). Bentonite clay was used as adsorbent surface to gather with complexes (1) and (4). The adsorption time investigated was between (15 - 120) min at (25)°C as constant concentration for complexes being (70) mg/L for complex (1) and (50) mg/L for Complex (4) and mesh 75))?m. The results revered that the time needed to reach concentration equilibrium in the were 60 to 75 min for complex (1) and (4). during studying isotherm adsorption for the two complexes on bentonite surface, the results revealed that the trend of the adsorption isotherm was (L1) type according to Giles classification , which means that the adsorbent distributed horizontally on the bentonite surface to from a single adsorption layer type langmire.The adsorption phenomenon was studied at different temperatures (10, 25, 37.5, and 50) oC. The results of the adsorption for both complexes on bentonite surface were showed an increase with increasing temperature (endothermic process). Thermodynamic functions (?Ho, ?Go, and ?So) were calculated and the results were discussed. Generally, the increase in the pH of solution was showed an increase in quantity of both complexes that adsorbed on bentonite clay surface at a certain temperature. The study proved that an increase of adsorbent weight may be enhanced the adsorption process of both complexes. Moreover, the particle size of clay surfaces has an influence on the adsorption process showing an increase in adsorption quantity as the particle size decreased.

تحضير وتشخيص بعض مشتقات الملئيمات الجديدة الحاوية على حلقات 2 - بايرازولين وبايرمدين - 2 - اون / ثايون ودراسة فعاليتها البايولوجية ثم بلمرتها ذايا او مع بعض معوضات الفاينيل == Preparation And Identification Some New Maleimide Derivatives Containing 2 - Pyrazoline And Pyrimidin - 2 - One / Thione Rings And Study of Biological Activity Then Homopolymerization Or With Some Substituted Vinyl

اسم المؤلف: غزوان حسن عبد الوهاب الصميدعي
اسم المشرف: احمد شهاب حمد الجنابي | خالد مطني محمد الجنابي
الموضوع العام: علوم الكيمياء
السنة: 2008
الموضوع الدقيق: علوم الكيمياء
الدرجة: دكتوراه
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: ترتبط بعض الامراض النفسية مثل مرض الاكتئاب الشديد والفصام بتغيرات مناعية حتى ولو كان الشخص سليم من الناحية الجسمية. على الرغم من ان هذين المرضين لايعتبران حاليا من الامراض المناعية الاساسية لكن توجد ادلة تقترح كون الالتهاب يلعب دورا في عملية الاصابة بالاك | Psychiatric illnesses, particularly major depressive disorder (MDD) and schizophrenia, are associated with inflammatory processes even in individuals who are otherwise physically healthy. While it is unlikely that MDD and schizophrenia are a primary inflammatory disorder, evidence suggesting that inflammation plays a subtle role in the pathophysiology of MDD and schizophrenia has been obtained. Several studies have shown that proinflammatory markers have increased in these disorders. However, these studies have included patients with obvious inflammation, i.e., patients with C - reactive protein >6 mg/L. A comprehensive study concluding that these conditions are inflammatory disorders and inflammation is due only to these two disorders have not been performed. In the present study, the inflammatory natures of MDD and schizophrenia were investigated. To achieve this goal, serum levels of the interleukins - 6 (IL - 6) and interleukins - 18 (IL - 18), tumor necrosis factor alpha (TNF?), and soluble interleukin - 2 receptor (sIL - 2R) in MDD and schizophrenia were obtained and compared with those of the control group. The total serum and ionized levels of calcium (Ca) and magnesium (Mg) in the studied groups were then measured.Significant increases (p < 0.05) in the serum levels of IL - 6, IL - 18, TNF?, and sIL - 2R in the MDD and schizophrenic groups were observed in comparison with those of the control group. In general, the schizophrenic group showed higher levels of inflammatory markers than the MDD and control groups. These results indicate a clear inflammatory state in both disorders. The schizophrenic patients exhibited significant changes in the ratios of T. Ca/Mg and I. Ca/Mg in comparison with those of the healthy and MDD patients; this finding reveals that T. Ca/Mg and I. Ca/Mg ratios are better indicators of cation state than serum cation levels alone.Basing on the results of the present study, we concluded that the immunological responses of the MDD and schizophrenia are significantly stimulated. These conditions may be considered inflammatory disorders because of increased pro - and inflammatory factors in both disorders.Anti - inflammatory drugs may be potentially used as an adjuvant aid in treating schizophrenia and MDD. Future studies may involve investigating other proinflammatory markers and following up results of treated patients that utilized and did not utilize anti - inflammatory drugs.

تحضير ودراسة طيفية ومعالجة نظرية لمعقدات مزيج ليكاندي مشتقات البنزاميدازول والفينانثرولين

اسم المؤلف: دعاء حبيب محل
اسم المشرف: محاسن فيصل الياس
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء العضوية
الدرجة: دكتوراه
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • تحضیر
  • حلقیة غیر متجانسة
  • جالكون، بایرازولین
  • ثنائي هایدروبایرمدین - - 2 اون
  • ثنائي هایدروبایرمدین - 2 - ثایون، بولي ایماید
  • فعالیة بایولوجیة
  • موجات فوق صوتیة Synthesis
  • Heterocyclic
  • Chalcone
  • derivatives
  • Pyrazoline
  • Dihydropyrimidin - 2 - one
الصفحات الاولى:
المستخلص: In this study, two new aromatic chalcones have been synthesized. The first one contain one amino phenyl group while the second contain two amino phenyl groups , from the reaction of 2 - acetothiophene or pamino acetophenone with p - or m - amino benzaldehyde respectively by Claisen - Schmidt condensation in alcoholic base medium (10%NaOH ).Also, some of heterocyclic compounds have been derived from these prepared chalcones as a derivatives for 2 - pyrazoline ring and for dihydro pyrimidine - 2 - one/thione as follows : 1 - Preparation of 3,5 - di (amino phenyl ) - 2 - pyrazoline (3,9) derivatives from condensation of (1,2) chalcone with hydrazine hydrate in absolute ethanol.2 - Preparation of 3,5 - di (amino phenyl) - 1 - phenyl - 2 - pyrazoline (4,10) derivatives by the reaction of chalcone (1,2)with phenyl hydrazine in presence of acetic acid.3 - Preparation of 3,5 - di (amino phenyl) - 1 - substituted - 2 - pyrazoline (5 - 7,11 - 13) from the reaction of chalcones (1,2) with semicarbazide, thiosemicarbazide and isoniazide in strong basic medium (45% NaOH) in absolute ethanol.4 - Preparation of 4,6 - di(amino phenyl ) - 3,4 - dihydro pyrimidine - 2 - one / thion (14,15) : from the reaction of chalcone(2)with urea and thiourea in presence of sodium ethoxide in absolute ethanol in two ways : thermal catalyse and ultrasonic waves with high yield for the last one.The phenyl amines derivatives (3 - 7,9 - 15)included benzidine (8) were converted into N - substituted maleimic acid (16 - 28) , by reacted it with maleic acid anhydride in ether or dry acetone.These derivatives (16 - 28) were undergo dehydration by using anhydrous acetic and sodium acetate to give N - substituted malimide products ( 29 - 41) in good yield.Also, the homopolymers (42 - 54) for these malimides were prepared by free radical polymerization with benzoyl peroxide as initiator and dimethyl formamide (DMF) as a solvent at 130 0C. PDF created with pdfFactory Pro trial version www.pdffactory.com The copolymers (55 - 104)have been prepared by the samemethod and initiator with vinyl acetate for polymers (55 - 67)and with acryl amide for polymers (68 - 72) and with allyl benzene for polymers (73 - 80) and with maleimide (31) for the polymers (81 - 88) , also with maleimide (32) for the polymers (89 - 96) and finally with maleimide (33) for the polymers (97 - 104).The structures of these new compounds were characterized by UV spectra (as a comparable study for unpolymered molecules ),IR (infra - red ) spectra and 1H - NMR (nuclear magnetic resonance ) spectra for some of the prepared compounds and followed by TLC (thin layer chromatography ).The stability of these compounds (9 - 12) were studied spectrally from the changing in its high absorbance values (peaks) ?max for their solutions at concentrations 2×10 - 5M in light and dark with time for comparability. These compounds showed good stability whichcan be suggested to be used as an organic reagents for analytical study especially with drugs and phenolic compounds.More ever, the identification study , here we have studied the heoretical study of formation heat for intermediates and final compounds bodies length of the bond which was agreement with the particularly results.This study ,also includes the biological activity for some of the prepared compounds against four kinds of germs which known by its resistance against antibiotics ,these are Staphylococcus aureus (positive for Gram stain )and Escherichia coli ,Pseudomonas aeruginosa and Salmonalla typhi (negative for Gram stain ) and studiesy the inhibition values for these compounds comparable with three of standard antibiotics as controls (ampicilline : C1, Cloxacilin : C2, erythromycin : C3) , and the results show the ability of these prepared compounds to inhibit all the used germs except Pseudomonas which shows clear resistant for less polarity comparable with control samples.

دراسة بايوكيميائية وجزيئية لتاثير مرض السكري من النوع الثاني على مستوى الهوموسيستين وعلاقته بالجين (SHMT1C1420T) == Biochemical And Molecular Study on The Effect of Diabetes Type II on Homocysteine Level And Its Relationship With Gene (SHMT1C1420T)

اسم المؤلف: حسام داود عبد الله
اسم المشرف: نزار احمد ناجي | عقيل حسين علي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: الكيمياء اللاعضوية
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم للبنات - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: في هذا البحث تم تحضير واستخدام ليكاندين من مشتقات ال 2 - مركبتوبنزاميدازول وهما 2 - بنزويل ثايو بنزاميدازول (L1) و2 - ) بارا نايتروبنزويل ) ثايوبنزاميدازول (L2) لتحضير نوعين من المعقدات احدهما بوجود الليكاند المشترك phenanthroline (L') 1,10 - مع ايونات ا | IN this work Two of 2 - mercaptobenzimidazole derivatives ligands 2 - benzoyl thiobenzimiazole (L1) and 2 - (p - nitrobenzoyl) thiobenzimiazole (L2) were prepared and used to synthesize two types of transition metal complexes ; One of the set of complexes was prepared in presence of a co - ligand 1,10 - phenanthroline(L') with the metal ions V(IV), Cr(III), Co(II), Ni(II), Cu(II), Cd(II) and Zn(II), the other set of complexes was prepared with the heavy metal ions Rh(III), Pd(II), Pt(IV) and Au(III) using conventional method. These ligands and their metal complexes were isolated and characterized in solid state using FT - IR, UV - Vis spectroscopy, Nuclear magnetic resonance spectra 1H, 13C - NMR, flame atomic absorption, elemental analysis C.H.N.S. and magnetic susceptibility measurements as well as melting point and conductivity measurements. The nature of bonding between the metal ion and the donor atoms of the ligands was demonstrated through the calculation of Racah parameter and other ligand field parameters, which were calculated using suitable Tanabe - Sugano diagrams. The nature of some (L2) complexes in liquid state was studied by following the molar ratio method which gave results approximately identical compared with those obtained from the isolated in the solid state; also, stability constants of the prepared complexes were studied , they were stable in the molar ratio 1 : 1.According to the results of the above measurements, the following shapes were suggested for the prepared complexes : Complexes of mixed ligands (L1 with L') : All complexes have an Oh geometry except V(IV) complex has a square pyramid geometry. Complexes of ligand (L2) : Complexes of Rh(III), Pd(II) and Au(III) have a square planar geometry, while Pt(IV) complex has an Oh geometry.A theoretical treatment of the ligands and the prepared complexes in gas phase was done using two programs; Hyperchem - 8 and Gaussian program (GaussView Currently Available Versions (5.0.9) along with Gaussian 09 which is the latest in the Gaussian series of programs).Hyper chem. - 8 program used the molecular mechanics and semi - empirical calculation, the heat of formation (?H?f), binding energy (?Eb) dipole moment (µ) for the free ligands and their metal complexes were calculated using ZINDO/1, PM3 and AMBER methods at 298 K. It was found that the complexes were more stable than their ligands; furthermore, the electrostatic potential of free ligands was calculated to investigate the reactive site of the molecules, PM3 was used to evaluate the vibrational spectra of free ligands ,the obtained frequencies agreed well with those values experimentally found; in addition, the calculation helped to assign unambiguously the most diagnostic bands.Electronic spectra measurements for the ligands were calculated theoretically using ZINDO/S method comparing it with the experimental results. It was found that there was a closely relationship between the theory and experimental spectra.Gaussian program semi - empirical (PM3) method which used in order to calculate : the geometry optimization, dipole moment (?),total energy ,electrostatic potential, ELUMO and EHOMO was obtained, evaluate the vibrational spectra of free ligands and these obtained frequencies agreed well with those values experimentally found.Also electronic spectra measurements for the ligands were calculated theoretically by using the job type : Single point energy (SP) along with ZINDO method and also the job type frequency (Freq) used along with CIS method (3 - 21G).

تقدير السلينيوم بالطرق الطيفية في نماذج حياتية وبيئية == Estimation of Se By Spectrophotometric Method In Vital And Environmental Samples

اسم المؤلف: داليا عبد الامير احمد
اسم المشرف: صادق جعفر باقر
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يعد مرض السكري من الامراض المزمنة الواسعة الانتشار في العالم، ومن المشاكل الصحية الرئيسية في معظم دول العالم يضم هذا المرض مجموعة من الاضطرابات الايضية المختلفة (كاربوهيدرات، بروتينات، دهون )، اهمها ارتفاع مزمن في مستوى سكر الدم، حيث ان لتحلل الكلوكوز ف | Diabetes is a chronic disease widespread in the world and lt is amajor health problem. It is agroup of metabolic disorderd including carbohydrates , proteins and lipids. It is considerded as chronic high blood sugar (hyperglycemia). The glycolytic pathway in the cells play an important role to produce the serine which is formed by turning the phosphoglycerate in a series of steps. Serine is behaved as a donor of methyl group catalyzed by serine hydroxyl methyl transferase to produce homocysteine in a series of steps using vitamine B12 and tetrahydro folate (folate cycle) to control the lack of homocysteine that causes high damage to the lining of arteries and other organs , which in turn leads to partial decrease in insulin secretion or lack of insulin receptors. This may effect the eyes , kidneys , blood vessels, and nerves. This research includes people with diabetes type II. admitted to the teaching hospital in Tikrit, Samples have been taken from 40 patients (22 males and 18 females) and (5) samples of healthy males from the staff of the University of Tikrit, The study included two parts : - 1 - Biochemical study : - included the measurement of plasma level of homocysteine from the blood of patients with type II diabetes which showed : - 1 - Significant increase (P

تحضير وتشخيص بعض مشتقات4، 2، 1 و4، 3، 1 - اوكسادايازول وتقييم فعاليتها البايولوجية == Synthesis And Characterization of Some (1,2 ,4 & 1,3 ,4) - Oxadiazoles And Evaluation Their Biological Activity

اسم المؤلف: بشرى فيصل نعمان
اسم المشرف: خالد مطني محمد الجنابي
الموضوع العام: علوم الكيمياء
السنة: 2009
الموضوع الدقيق: الكيمياء اللاعضوية
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم للبنات - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: في هذه الدراسة تم تحضير ثلاثة ليكاندات ازو اميدازول جديدة (L1 - L3) وتم تشخيصها بوساطة اطياف ,C.H.N ,1HNMR, 13CNMR, UV - Vis, I.R طيف الكتله اضافه الى الطرائق الفيزيائيه من ذوبانيه ودرجة انصهار.حضرت عدد من المعقدات الجديدة لايونات Cd(II), Zn(II), Ni(II) | In this work, three azo imidazole ligands [L1 (2,3 - DMBAI), L2 (2 - CyBAI) and L3 (4 - SuBAI) ] have been prepared and characterized by I.R, UV - Vis spectra, (C.H.N.) microanalysis, 1HNMR, 13CNMR, mass spectroscopy and other physical properties like solubility and melting point measurements.A wide range of new complexes of Co( ), Ni( ), Cu( ), Zn( ), Cd ( ) and Hg ( ) with azo ligands (L1 - L3) were prepared after fixing the optimum conditions of pH and molar concentration. The structures of these complexes were assigned according to the molar ratio, which was obtained from the spectroscopic studies of the complexes solution of the above metal ions. However, metal - ligand (M : L) ratio of 1 : 2 were obtained.Stability constant have been founded in optimum concentration and optimum pH of complexes.The percentages of the metals in the complexes have been measured by flame atomic absorption spectrophotometer (A.A.) technique. Conductivity measurements with optimum concentration of prepared complexes have shown non - ionic character for all complexes in ethanol.The magnetic susceptibility measurements of Zn ( ), Cd ( ) and Hg ( ) complexes exhibit diamagnetic behavior, while paramagnetic properties were recorded for all the other complexes The UV - Vis spectra of the prepared complexes showed bathachromic shift in ?max , while the IR spectra ( using KBr disc) of the complexes showed changes in the band shape and density formed with those of the free ligand which indicated the complexation between the metal ions and ligands through the N atom of imidazole and azo group The analysis results showed that the proposed geometrical structure were octahedral configuration for all complexes and the general formula are : [M (Ln)2 X2 ]. mH2O , when M= Co( ), Ni( ), Cu( ), Zn( ),Cd ( ) and Hg ( ) ; L= ligands ; n= 1 - 3; X= Cl ; m= 0,1,2.

تحضير وتشخيص بعض مركبات قواعد شف الحلقية الجديدة ودراسة انتقائية معقداتها وبوليمراتها الكلابية == Synthesis And Characterization of Some New Heterocyclic Schiff Bases And The Study of Their Metal Ions Selectivity Complexes And Chelating Polymers

اسم المؤلف: دينا سعدي احمد مخلف الفلاحي
اسم المشرف: علي طه علي السامرائي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: تتضمن هذه الدراسة تحضير مشتقات الاوكسادايازول (4,2,1 و4,3,1) ودراسة الفعالية البايولوجية لبعضها وذلك بتحضير المركب 2 - امينوثايازول حامض الخليك (1) من تفاعل 2 - امينوثايازول مع كلورو حامض الخليك في الايثانول المطلق ثم تحضير معوضات الاميدواوكزيم (6 - 2) ا | This study deals with the synthesis of (1,2,4 & 1,3,4 - ) Oxadiazole compounds and evaluation their biological activity.The synthesis was outlined as follows : - 1 - 2 - aminothiazole acetic acid (1) was prepared through the reaction of 2 - aminothiazole with chloroacetic acid.2 - Some new amidoxime derivatives (2 - 6) were synthesized by the reaction of substituted aromatic nitriyle with hydroxylamine hydrochloride.3 - the reaction of compound(2 - 6) with 2 - aminothiazole acetic acid (1) in the presence of (DCC) afforded compounds (7 - 11) namlly; N - O - (subs) amidoximyl - thiazol - 2 - yl - amino carboxylate. cyclo dehydration reactions of compounds(7 - 11) by heating yielded the corresponding1,2,4 - oxadiazol (12 - 16).4 - 5 - pyridyl - 1,3,4 - oxadiazole - 2 - thiol (17) was prepared by the reaction of Nicotinic acid hydrazide with carbondisulfide (CS2) in alcoholic(KOH).5 - Reaction of compound (17) with aryl halides in the presence of alcoholic(KOH)yielded the corresponding thioethers (18 - 25). 6 - Some hydrazone derivatives (28 - 30) were prepared by the condensation reaction of benzoic acid hydrazide (27) with appropriale aromatic aldehyde , these hydrazone were cyclized to the corresponding1,3,4 - oxadiazoles (31 - 33) using(PbO2) in glacial acetic acid. These compounds were characterized by asins available spectroscopic methods (UV,IR and NMR) , the spectral data obtained are combatable with the structures assigned to these compounds , some of these compounds were tested againstThis study also include the evaluation of biological activity of some prepared (12,13,14,15,16,18,19,20,21,23,24,25,31,32&33) on the growth of four types of pathogenic bacteria , (Escherichia coli, pseudomonas auruginosa, klebsela pneumoniae (gram negative) and staphylococcus aurous (gram positive) ).The results abtained are shown in tables (22 - 24).

تحديد الظروف الفضلى للتفكك الضوئي لصبغة الاليزارين الصفراء على سطح اوكسيد الزنك المعدل والمسند == Determination The Optimum Conditions For The Photo Degradation of Alizarine Yellow Dye On The Surface of Modified And Supported Zinc Oxide

اسم المؤلف: سوزان ضياء رؤوف
اسم المشرف: احمد كاظم عباس
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تم في هذا البحث تحضير عدد من مركبات قواعد شف الحلقية غير المتجانسة وكما في الجدول ادناه : التركيب الرمز جرى تشخيص المركبات المحضرة باستخدام درجات الانصهار,الطرق الطيفية , FT - IR , H1 NMR , CHN Analysis ثم درست قابلية المركبات على تكوين معقدات ملونة ذائبة | The synthesis of heterocyclic schiff bases was achieved as shown in the table below : structure codeIn the first part of this work all the compounds were characterized by their M.p,IR,H1NMR and Elemental analysis CHN.In the second part ,the new compounds were examined by (spot test) for their metal complexes only compound D gave coloured compound with Cu2+ ions.A detailed study for this complex was carried for L/M ratio by mole ratio and continous variation method , calibration curve of Cu2+ ions were established depending on compound D.In the third part ,compounds A,B,C were loaded on poly urethane foam with 5% of the compounds and compound E with 10% to the foam so that chelating polymers P1,P2,P3,P5 were prepared respectively.Compound D was copolymerized with bis phenol A because its phenolic schiff base to produce polymer P4 with 10% of compound D.A complete analytical study for the prepared polymers regarding their loading capacity for different ions specially transition metal ions and heavy metals like Pb2+ and Cd2+ which are a major source of pollution.The study included two major factors i.e treatment time and pH and was conducted by batch study.Polymers P1,P2 and P3 showed same behavior towards the studied ions , on the other hand polymer P4 showed the highest loading capacity for all ions while polymer P5 showed the lowest this can be shown as : - Loading capacity P5< P1 , P2 , P3 < P4The highest loading capacity in all polymers was for Pb2+ ions , other ions were different in their order according to each polymer.A study for the regeneration of loaded polymer P5 (as an example) was conducted using (4M) HCL. The %recovery of Cr3+,Pb2+ and Co2+ was almost 90% or higher but Ni2+ was only 30% recovered.

دراسة بعض المتغيرات الكيموحيوية والمناعية في النساء المجهضات خلال الثلث الاول من الحمل == Study of Some Biochemical And Immunological Parameters in Abortifacient Women During First Trimester of Pregnancy

اسم المؤلف: انتصار فاضل مصطفى
اسم المشرف: صباح حسين خورشيد | نزار احمد ناجي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: تضمنت الرسالة تحضير العامل المساعد اوكسيد الزنك بطريقة الترسيب وقد تم تشخيصه بوساطة تقنية حيود الاشعة السينية XRD)) والاشعة تحت الحمراء (FTIR) والاشعة فوق البنفسجية - المرئية (..(UV - Vis تم دراسة تاثير درجة حرارة التلدين على الفعالية الضوئية لاوكسيد الزن | This work included preparation of zinc oxide by precipitation method. characterization of sample prepared work by using X - Ray Diffraction (XRD) and infrared spectra (FTIR) and Ultraviolet - visible spectra (UV - Vis). The effect of calcination temperature was studied on the photo activity of zinc oxide and physical properties such as surface area and porosity and density. The results showed that annealing temperature 773K was the best for the preparation of zinc oxide , which gave a good physical properties. The adsorption of Alizarin gelb dye (A.G) on the surface of zinc oxide was studied and it was found that the equilibrium time required was 30 min.. The kinetics of photo reaction of dye was studied in the presence of catalyst and oxygen through the irradiation of the dye solution by medium pressure mercury lamp at a temperature of 298 K and it was found that the order of reaction was first order. The optimum conditions for photooxidation of the dye was determined by studying several factors such us : dye concentration at the range (30 - 70) mg/L and it was found the optimum concentration was 40 mg/L , weight of zinc oxide at the range (0.05 - 0.9) g and it was found that the optimum weight was 0.3 g , pH of the medium at the range (3 - 11) and it was found that the optimum pH was 8 , different oxidants (potassium dichromate, potassium persulfate and hydrogen peroxide) and it was found that the highest percentage of dye decolorization was by using of hydrogen peroxide, The effect of doping transition metal ions (Co2+,Ni2+,Cu+2) it was found that undoping zinc oxide possessed higher activity from doped oxide , Effect presence of support materials such as (alumina, silica, bentonite, activated charcoal) on the dye decolorization and it was found that the higher percentage was by using activated charcoal.

التقدير الطيفي للاكسده الضوئيه المحفزه للباراسيتامول والبروكائين == Spectrophotometric Determination of Photocatalytic Oxidation of Paracetamol And Procaine

اسم المؤلف: الاء جواد عبد الزهرة الخاقاني
اسم المشرف: مثنى صالح مشكور | عامر موسى جودة
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء الحياتية
الدرجة: ماجستير
الجامعة: جامعة الكوفة - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: النجف
الصفحات الاولى:
المستخلص: تم في هذا البحث دراسة بعض اسباب ومتغيرات الاجهاض عند النساء عن طريق قياس هرمونات الغدة الدرقية(Thyroid gland) (T3,T4,TSH)، وهرموني البروجستيرون (Progesterone) والبرولاكتين(Prolactin)، وكذلك قياس مستويات السكر في الدم (Blood Sugar) ومستوى الدهون كـ( الكول | This study concluded the causes of abortion ( via estimation the thyroid gland hormones( T3, T4 ,TSH ) and both the progesterone and Prolactin as well as the estimation of the levels of blood sugar , cholesterol , triglyceride , high density lipoprotein( HDL) , low density lipoprotein( LDL) , and very low density lipoprotein( VLDL).The concentrations of the immunological test (TORCH) has been estimated which include : Toxoplasma ,Rubella , Cytomegalo , Herpes simplex virus II and the mean of haemolytic disease of newborn for women of negative Rh. Samples of 101 patients have been collected from General Kirkuk hospital who have suffered from multi abortion (Three times or more) with their ages ranged between 16 - 45 years. Forty blood samples of normal pregnants together with other forty samples of non - pregnant women were used for comparason.The following results are obtained from this study : 1 - Elevation of blood sugar level in aborted women compared to those of normal pregnant 2 - Significant decrease in thyroid hormone (T3 & T4) in aborted women compared to those of normal pregnant women. 3 - Significant increase in the concentration of TSH of aborted women compared with non - pregnant women. 4 - Significant decrease in Prolactin level in repeated abortion compared with those of normal pregnants. 5 - Significant decrease in progesterone level in aborted women compared to those with normal pregnant and non - pregnant women. 6 - Significant increase in cholesterol level in the groups of women who suffered from repeated abortion compared to groups of women of normal pregnant. 7 - Significant increase in the levels of triglyceride of aborted women compared to the groups of normal pregnant women.8 - Significant increase in LDL level in aborted women compared to those of normal pregnant.9 - Significant increase in VLDL level in repeated aborted women t compared to normal pregnant women.10 - Significant increase in the levels of HDL in aborted women compared to those with normal pregnant.11 - The investigation of IgM in Toxoplasma ,results reflects five positively infected cases out of 101 cases of aborted women and 28 positively cases of IgG out of 101of aborted women.12 - The investigation of Cytomegalovirus reflects 8 positively infected cases out of 101 in aborted women and 98 positive cases out of 101 aborted women.13 - The investigation of IgM of Rubella reflects 2 positively infected cases out of 101 aborted women and 92 positive cases in IgG class out of 101 aborted women.14 - The investigation of anti virus of Herpes simplex virus II IgG reflects 6 positively infected cases out of 101 of aborted women.15 - The investigation of negative Rh. appeared that there were no positive cases in the group of (5) negative Rh. women out of 101 of abortive women.

تحضير ودراسة حركية التفكك الضوئي لمعقدات الموليبدنيوم المخلبية مع ثنائي الكيل ثنائي ثايوكاربامات وN,N - ثنائي مثيل هيدرازين == Preparation And Kinetic Study Photodecomposition of Chelates Molybdenum Complexes With Dialkyl Dithiocarbamat & N,N - Dimethyl Hydrazine

اسم المؤلف: حسن خضر ناجي
اسم المشرف: حسن عباس حبيب
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تم تصميم الدراسة الحالية للتخلص من عقاري الباراسيتامول والبروكائين باستخدام الاشعة الفوق بنفسجية وبوجود اوكسيد الزنك كعامل مساعد، حيث سلطت الدراسه الضوء على اهمية كل من الضوء والعامل المساعد كعوامل اساسيه في التفكك الضوئي المحفز لكلا الدوائين.تضمنت الدرا | The current study is designed to treat the paracetamol and procaine by using UV light and ZnO as catalyst. This study explains the importance of the UV light and catalyst as a basic factors in the photocatalytic degradation for both paracetamol and procaine drugs. The study includes the measure of the rate of photocatalytic oxidation by measuring the absorbance of samples of aqueous solution for both drugs which is treated by UV light and ZnO. These absorbance are compared with the initial drug's absorbance. Some parameters which are effected on the rate of photocatalytic oxidation are studied in present research such as the amount of catalyst, initial concentration for the drug's solution, pH and the temperature for the drug's solution. The results show that the photocatalytic oxidation reaction for the paracetamol and procaine obey pseudo - first order according to the Langmuir - Hinshelwood relationship, and also it is found that the photoctalytic oxidation rate fits positively with the increase of the catalyst weight until the weights of ZnO equal to 0.025 g and 0.1 g are considered the optimum weights for paracetamol and procaine respectively where the best photocatalytic degradation is happened. So after these values, the photocatalytic degradation rate is decrease or stablized with the increase of the catalyst weight. In addition, the initial concentration increase for both drugs leads to reduce degradation rate. Also this study is found the increase of pH of reaction solution for both drugs has a positive effect represented by increasing the degradation rate until the pH 8 and 4 are the best acidic function of the paracetamol and procaine respectively. Regarding the change of the temperature has a little effect on the rate of photocatalytic degradation and it was noticed that the reaction rate increases with the increase of temperature. Activation energy is calculated according to the Arrhenius plot of lnK vs. 1/T, the slop of linear plot is equal to ( - Ea/R). Activation energy was found equal to 7.96 KJ. mol - 1 for paracetamol and 8.71 KJ. mol - 1 for procaine. The thermodynamic functions are calculated in current study for each drug and the results for paracetamol are as following : ?G = 63.61 ± 2.85 KJ.mol - 1?H = 5.40 ± 0.13 KJ.mol - 1?S = - 0.189 KJ.K - 1.mol - 1And the results of procaine are as following : ?G = 63.43 ± 2.81 KJ.mol - 1 ?H = 6.15 ± 0.13 KJ.mol - 1?S = - 0.186 KJ.K - 1.mol - 1The results of the suggested mechanism of degradation are shown that the final products for degradation are CO2, H2O and mineral acids.

تحضير ودراسة الفعالية الحيوية لبعض مشتقات الكرمارين الجديدة == Synthesis And Study Biological Activity of Some New Coumarin Derivatives

اسم المؤلف: قاسم عبد الحسين جابر الشيباني
اسم المشرف: نبيل عبد عبد الرضا
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تم في هذه الدراسة تحضير المعقدات على النحو الاتي : 1 - اوكسو 1,1 - ثنائي مثيل هايدرازيدو - ثنائي( ثنائي اثيل ثنائي ثايوكارباماتو) موليبدنيوم (VI) 2 - اوكسو 1,1 - ثنائي مثيل هايدرازيدو - ثنائي(ثنائي مثيل ثنائي ثايوكارباماتو) موليبدنيوم (VI) 3 - اوكسو 2,1 | In this study for complexes have been prepared are : 1 - Oxo 1,1 - dimethyl hydrazido - bis (diethyl dithiocarbamato) molybdenum (VI). 2 - Oxo 1,1 - dimethyl hydrazido - bis (dimethyl dithiocarbamato) molybdenum (VI) 3 - Oxo 1,2 - dimethyl hydrazido - bis (diethyl dithiocarbamato) molybdenum (VI). 4 - Oxo 1,2 - dimethyl hydrazido - bis (dimethyl dithiocarbamato) molybdenum (VI). Via two intermediate complexes are di oxo bis (diethyl dithiocarbamato) molybdenum (VI) and di oxo bis (dimethyl di thiocarbamato) molybdenum (VI). All complexes was characterized spectrophometically by UV - vis and FTIR. The kinetic of photo chemical reaction have been studied for these complexes by irradiate there solution by mono wave length light at (?= 366nm)supplied from medium pressure mercury lamp at 293 K for 90 minutes by using ethanol as solvent. Following the photo chemical reaction showed the order of photo dissociation reaction is pseudo - first reaction for all complexes and reaction rate constants were calculated , so the spectrum change were recorded during irradiation period. The effect of several factors have been studied included : period of irradiation , complex concentration , light intensity , PH value , solvent polarity and temperature. Where the periods of irradiation time were followed which last in the complex dissociation , were between 390 - 450 min. study of seven concentration of all complex where the dissociation rate was proportional inversty with concentration , so the dissociation increases when light intensity increase , and notice that changing in pH value between 4 - 10 lead to dissociation increment toward naturalization and decrease when alkalinity rise. According to the solvent effect , the photodissociation take the sequence for all complexes Isopropanol > 1 - butanol > Ethanol > Methanol. Besides the photo dissociation of all complexes was studied in the range 283 - 303 K and found that in the temperature rising the rate of dissociation rises and the activation energy for all complexes and study was calculated. Quantum yields have been calculated for all prepared complexes and the value was more than one , it raters to the photolysis was chain reaction and reaction done by heterogonous splitting of metal - ligand bond according to uv - vis spectrums where oxidation of ligand and the metal was reduced giving opposite complexes

دراسة طيفية لعدد من معقدات انتقال الشحنة لقواعد شف وحركيات الانحلال الضوئي للقواعد == Spectral And Photo Decay Kinetic Study for A Number of Charge - Transfer Complexes of Schiff Bases

اسم المؤلف: بشرى كامل نجم الفراجي
اسم المشرف: عبد الرحمن خضير عبد الحسين الطائي | نشوان عمر رشيد تبة باشي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: The thesis included the preparation of a number of new compounds derived from coumarin. In the first stage was to prepare two of the main compensators coumarin and published by preparation methods known , It was the preparation of compound 3 - acetyl coumarin [70] via Biginelli condensing and through reaction Salicyladehyde with ethyl acetoacetate in existence Piperidine. also prepared compound 3 - Carbomethoxy coumarin [85] in the same way by reaction Salicyladehyde with dimethyl malonate in existence Piperidine.Then, depending on the substituted groups in the two compounds [70] , [85] was the synthesis of other derivatives, namely : 1. Prepare derivatives [71] , [72]through reaction compound [70] with Phenyl hydrazine to produce derivative [71] or with 4 - Nitrophenyl hydrazine to produce derivative [72].2. Prepare derivatives [73] , [74] by Fischer reaction and through treatment of derivatives [71],[72] with poly phosphoric acid to produce a derivatives [73] , [74]respectively.3. Prepare derivatives [75] , [76] by Vilsmeier - Heack reaction and that the treatment derivatives [71] [72], with a mix of (DMF / POCl3) to produce a derivatives[75] , [76] respectively.4. Prepare derivatives [77] , [78] through reactance derivatives [71] , [72] with Copper acetate aquatic in acidic medium to produce a derivatives [77] , [78] respectively.5. prepare a series of derivatives [79 - 84] by Biginelli reaction and through treatment of compound [70] with a number of substitute aromatic aldehydes and urea in acidic medium and get on derivatives [79 - 84].6. prepare a series of derivatives [86 - 88] through reaction compound [85] with a number of primary aromatic amines in acidic medium and get on derivatives [86 - 88].7. prepare a series of derivatives [89 - 92] through reaction compound [85] with Piperazine and its derivatives in the acidic medium and get derivatives [89 - 92].In addition in this research was assigned the structures of some new derivatives via spectroscopic methods (FT - IR) and (1H NMR) and (13C NMR) and (HSQC, HMBC) in addition to accurate analysis of the elements (CHN), has demonstrated diagnostic studies the success of the chemical reactions and the health of chemical compositions of the derivatives prepared.As has been the study of biological effectiveness of some prepared compounds and the results showed a difference in their effect on bacteria and fungi, it was found that most of the derivatives prepared possess biological activity in the killing and inhibition of bacteria (E.coli, Staphylococcus aureus), as well as fungi (Candida albicans, Aspergillus niger) so as to contain aldehyd and hydroxyl groups and fluorine atoms, chlorine, and heterogeneous episodes that make these derivatives are more effective than the base compound in inhibiting and killing bacteria.

تحضير بعض مشتقات المركبات الحلقية غير المتجانسة المتضمنة حلقات رباعية وخماسية وسباعية وحلقة البايرازولين وتقييم تاثيرها على انواع مختلفة من البكتريا والفطريات == Synthesis of Some Deriativel Heterocyclic Compounds Containing Four, Five, Seven - Membered Rings And Pyrazol - 5 - One And Evaluate The Biological Activity of Some Bacteria And Fungies

اسم المؤلف: هبة حمزة رشيد لطيف التكريتي
اسم المشرف: خالد مطني محمد الجنابي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: تتضمن الدراسة عدة اجزاء : الجزء الاول : تحضير مجموعة من قواعد شف من تكثيف البنزلديهايدالمعوض بالمواقع بارا بمجاميع( بارا - برومو، بارا - كلورو، بارا - نايترو، بارا - N,N - ثنائي مثيل امينو بنزالديهايد ) مع معوضات الانلين المختلفة (بارا - امينو اسيتوفينو | This Work was accomplished through the following four part : Part one In this part nine Schiff bases derived from p - substituted benzaldehyde) with (p - bromo aniline , p - amino acetophenon, aniline, 2 - amino phenol were prepared.The electronic spectra in absolute ethanol solution were used to study the intermolecular charge - transfer complexes between the considered Schiff bases as charge donor , and iodine as charge acceptor molecules.The physical parameters of charge - transfer complexes were calculated by applying Bensi - Hildebrand equation. The equilibrium Constants for complexes formation were found to follow (3<4<9<6<7<8<5<1<2) arrangement. The energy of the complexes and extiztion coefficient were found to have the same arrangement shown above. The difference in the values of this physical properties are attributed to structural difference of the molecular (donating and withdrawing substituted groups). KCT values for the complexes were calculated from Bensi - Hildebrand equation and was found to fit the following arrangement ( 9<8<7<4<3<6<5<1<2 ), depending mainly on the types of substituted groups on aniline ring. Part Two Effect of temperature variation on equilibrium constant for the charge - transfer complexes formation were measured by applying Bensi - Hildebrand equation ,which used to estimate the thermodynamic parameter such as (?G0, ?S0 , ?H ) in absolute ethanol. Part Three The kinetic of the formation of charge - transfer complexes in absolute ethanol was studied.The results indicated that, the more stable charge - transfer complexes have higher rate constant formation and the kinetic of CTC was first order. Part Four Photo stability of (1 - 9) Schiff bases against direct sun light was investigated as solution in both ethanol and dimethyl sulfoxide DMSO.The results indicated that, the rates of photo decay of the Schiff bases in ethanol were faster than in DMSO solvent and the photo decay kinetic was found to follow first order reaction in ethanol and second order in DMSO solution.

المتحسس الكهروكيميائي المعتمد على الاقطاب المطورة == Electro Chemical Sensor Based on Modified Electrodes

اسم المؤلف: مثنى سعيد علي كريم
اسم المشرف: سهام توفيق امين | عبد الرحمن خضيرعبد الحسين الطائي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: الكيمياء العضوية
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: الدراسة تتضمن ثلاثة خطوات : - الخطوة الاولى : _ تحضير قواعد شيف (H1 - H15) التي تحتوي على موقع بارامع رسم المجموعات تحتوي على التحضيرات على التوالي في وسط متعادل خلال التفاعل بين مركبات الامينات الاروماتية ومعوضات البنزلديهايد في الايثانول المطلق. الخطوة | First step Schiff bases [H1 - 15] containing Para donating and with drawing groups have been prepared respectively in a neutral medium, through the reaction between aromatic amines compounds and substituted enz aldehyde in absolute ethanol. Second steppreparation of some of heterocyclic compounds include 3 - chloro - 2 - oxo - zetidine - 2 - one (H16 - 30) through its rection with chloro acetyl chloride in presence of tri ethyl amine in 1,4 - Dioxan and2 - (substituted aryl)thiozoldin - 4 - one (H31 - 40) is prepared from the reaction of thioglycolic acid with Schiff bases in presence of zinc chloride in dry Benzene and2 - (sub.aryl) - 5,7 - di - one oxazipene (H41 - 50) are synthesized by cyclization of Schiff bases using malic anhydride in methanol.Third stepthis part of the research included the preparation of compounds similar to chalcones which are the phenyl propene amide derivatives by the condensation of acetanilide and substituted acetanilide with substituted benzadehydes The phenyl propene amide derivatives were reacted with hydrazaid(iso nazaid) is preparation of Pyrazoline compounds (H56 - 60) are synthesized from the reaction of chalcons (H50 - 55).The structures of the synthesized compounds were supported by means of (FTIR), (UV - Vis), (1H - NMR) and the results are agreement with the proposed structures assigned to the synthesized compounds. Study of the biological activity for prepared compounds The study also includes the biological activity for some of the prepared compounds against four kinds of germs which known by its resistance against antibiotics, these are the compounds (H18,H31,H35,H41,H42,H53,H5) are tested on four types of germs which cause illness and resist the antibiotic agents and these germs( Bacillus submits, E - coli, salmonella, Enter course)and study the biological activity for some of the activity using different concentration and different type of fungous The results showed prominent activity against these bacteria, the detailed antibacterial screening are reported in Table (15) and the Inhibition of the fungus screening are reported in Table (16).

التقدير الطيفي للترايفلوبيرازين والكلوربرومازين في المستحضرات الصيدلانية باستخدام تفاعلات الاكسدة == Spectrophotometric Determination of Trifluoperazine Hydrochloride And Chlorpromazine Hydrochloride in Pharmaceutical Formulation By Oxidation Reactions

اسم المؤلف: عمر عدنان هاشم شريف ال ابليش
اسم المشرف: علي ابراهيم خليل الجبوري | محسن حمزة بكر
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: علوم الكيمياء
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: This study contained ageneral introduction about the Ion - Selective electrodes and ageneral introduction about Schiff's Base and the determination of Diphenhydramine Hydrochloride (DPH) and Phenylephrine Hydrochloride (PEH) and Metoclopramide Hydrochloride (METO) and Metformin Hydrochloride (METF ) drugs using new methods applying potentiometric (the first part) and using Schiff's Base as ionophor In ISES membranes ( the second part).The first part includes construction of membrane selective electrodes for DPH and PEH drugs based on complexation of drugs with Ammonium Reinckate (AR) and Phospho Molybdic acid (PMA) as an active substance using Di - n - Butyl phthalate (DBPH) as a plasticizers , poly vinyl chloride was used as a matrix for all electrodes.The Characters of each electrode were as follow : 1. For the Diphenhydramine - Ammonium Reinckate (DP - AR) electrode using (DBPH) as a plasticizers, the optimum condition were (4.5 - 6.5), (20 - 30?C), 10 - 2 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29.40) mv/decade, correlation coefficient r= 0.9971, detection limit (8.88x10 - 7 M) and life time of the electrode was 34 days.2. For the Diphenhydramine - Phospho Molybdic acid (DP - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (4.5 - 6.5), (20 - 30 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 90) mv/decade, correlation coefficient r= 0.9960, detection limit (6.8x10 - 8 M )and life time of the electrode was 40 days.3. For the Phenylephrine - Ammonium Reinckate (PE - AR) electrode using (DBPH) as a plasticizers, the optimum condition were (5 - 6), (25 - 30 ?C), 10 - 3 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29.8) mv/decade, correlation coefficient r= 0.9990, detection limit (2.22x10 - 7 M) and life time of the electrode was 24 days.4. For the Phenylephrine - Phospho Molybdic acid (PE - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (5 - 6), (25 - 30 ?C), 10 - 3 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29.5mv\decade), correlation coefficient r= 0.9990, detection limit (4.87x10 - 7 M ) and life time of the electrode was 26 days.The second part includes the use of Schiff's Base as ionophor in ISES MembranesThe second part includes construction of membrane selective electrodes for METO and METF drugs based on complexation of drugs Schiff METO and Schiff METF as Ionophor with Phospho Molybdic acid (PMA) as an active substance using Nitro benzene (NB) and Di - n - Butyl phthalate (DBPH) as a plasticizers , poly vinyl chloride was used as a matrix for all electrodes.The Characters of each electrode were as follow : 1.For the Metoclopramide - Phospho Molybdic acid (Schiff’s METO - PMA) electrode using (NB) as a plasticizers, the optimum condition were (4 - 6), (20 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (19.90) mv/decade, correlation coefficient r= 0.9970, detection limit (4.5x10 - 7 M) and life time of the electrode was 122 days.2.For the Metoclopramide - Phospho Molybdic acid (Schiff’s METO - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (4 - 6), (20 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively. The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 70) mv/decade, correlation coefficient r= 0.9950, detection limit (3.83x10 - 7 M )and life time of the electrode was 108 days.3.For the Metformin - Phospho Molybdic acid (Schiff’s METF - PMA) electrode using (NB) as a plasticizers, the optimum condition were (5 - 6), (25 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 30) mv/decade, correlation coefficient r= 0.9970, detection limit (3.87x10 - 7M )and life time of the electrode was 102 days.4.For the Metformin - Phospho Molybdic acid (Schiff’s METF - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (5 - 6), (25 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 10) mv/decade, correlation coefficient r= 0.9980, detection limit (2.37x10 - 7 M )and life time of the electrode was 90 days

دراسة تاثير الفسفاتين وبعض المتغيرات الحياتية على مرضى سوفان المفاصل المصابين وغير المصابين بداء السكري من النوع الثاني == A Study of Visfatin And Some Biochemical Variables In Osteoarthritis With And Without Diabetes Mellitus Type2

اسم المؤلف: لمياء شاكر عاشور
اسم المشرف: طارق محمد علي رجب الحكيم | حامد غفوري حسن
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: يتضمن هذا الفصل مقدمة عن المركبات الدوائية الاتية وطرائق تقديرها وهي : • الترايفلوبيرازين هيدروكلوريد Trifluoperazine Hydrochloride • طرائق تقدير للترايفلوبيرازين هيدروكلوريد Methods for the determination of Trifluoperazine hydrochloride • الكلوربروم | This thesis consists of four chapters : Chapter one : contains introduction about drug compounds listed below - Trifluoperazine hydrochloride. - Methods for the determination of Trifluoperazine hydrochloride. - Chlorpromazine hydrochloride. - Methods for the determination of Chlorpromazine. - Aim of the research.Chapter two The Chapter includes the development of a new sensitive spectrophotometric method for the determination of a Trifluoperazine hydrochloride in aqueous solution. The method is based on the oxidative coupling reaction of Trifluoperazine hydrochloride with Sulphanilic acid reagent in a acidic medium pH 1.4 in the presence of Potassium Iodate to produce an intense violet coloured, water soluble and stable product , which exhibits maximum absorption at 544 nm. Beer’s law is obeyed over the arange 12 to 66 µg.ml - 1 of Trifluoperazine hydrochloride, with a molar absorptivity of 4804 L.mo1 - 1.cm - 1 , Sandell’s sensitivity index of 0.01 µg.cm - 2 , relative error range not more than 1.26% , and D.L 0.495 µg.ml - 1. The method has been successfully applied for the determination of Trifluoperazine hydrochloride in tablets.Chapter threeThe Chapter includes the development of a sensitive spectrophotometric method for the determination of Trifluoperazine hydrochloride in aqueous solution based on reduction of Fe3+ with Trifluoperazine hydrochloride. The Fe2+ formed is complexed with 2,2’ - bipyridyl at pH 4.2 to produce a red , water soluble and stable complex, which exhibits maximum absorption at 524 nm. Beer’s law obeyed in the concentration range from 2 to 50 µg.ml - 1 of Trifluoperazine hydrochloride. The molar absorptivity is 5284.4 L.mol - 1.cm - 1 and Sandell’s sensitivity index of 0.090 µg. cm - 2 , relative error from 1.64 % , and D.L 0.788 µg.ml - 1. The method has been successfully applied to the determination of Trifluoperazine hydrochloride in tablets.Chapter FourThe Chapter includes the development of a new sensitive spectrophotometric method for the determination of a Chlorpromazine hydrochloride in aqueous solution. The method is based on the oxidative coupling reaction of Chlorpromazine hydrochloride with Sulphanilamide reagent in a acidic medium pH 3.2 in the presence of Ammonium ceric Sulphate dihydrate to produce an intense violet coloured, water soluble and stable dye, which exhibits maximum absorption at 530 nm. Beer’s law is obeyed over the arange 6 to 66 µg.ml - 1 of Chlorpromazine hydrochloride, with a molar absorptivity of 2842.28 L.mo1 - 1.cm - 1 , Sandell’s sensitivity index of 0.1250 µg.cm - 2 , relative error range not more than 2.49 % , and D.L 1.2028 µg.ml - 1. The method has been successfully applied for the determination of Chlorpromazine hydrochloride in tablets.

دراسة مستوى انزيم الرينيين والفا - ل - فيوكوز وبعض المتغيرات الكيموحيوية للمرضى المصابين بالعجز الكلوي المزمن == Level of Renin Enzyme, ? - L - Fucose And Some Biochemical Markers for Chronic Renal Failure Patients

اسم المؤلف: سروت بهرام عارف محمود الكاكةئي
اسم المشرف: صباح حسين خورشيد
الموضوع العام: علوم الكيمياء
السنة: 2013
الموضوع الدقيق: الكيمياء الحياتية
الدرجة: ماجستير
الجامعة: جامعة تكريت - كلية التربية للعلوم الصرفة - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: خلفيه البحث : سوفان المفاصل هو مرض مزمن يؤدي الى حدوث تغيرات ضارة في الغضاريف والعظام والاربطة والعضلات , علما ان وصف المرض بشكل دقيق غير محدد لحد الان. والسؤال المطروح عن العلاقة بين العلامات الناتجة عن هذا المرض وتلك الناتجة عن مرض السكري, هل الام السك | خلفيه البحث : سوفان المفاصل هو مرض مزمن يؤدي الى حدوث تغيرات ضارة في الغضاريف والعظام والاربطة والعضلات , علما ان وصف المرض بشكل دقيق غير محدد لحد الان. والسؤال المطروح عن العلاقة بين العلامات الناتجة عن هذا المرض وتلك الناتجة عن مرض السكري, هل الام السكري تخفي الام المفاصل ؟ حيث ان كلا المرضين(السكري والمفاصل) هما من الامراض المزمنة وتتصف بمستويات غير واضحة من التغيرات البايولوجية للمريض.الهدف من البحث : صممت هذه الدراسة لايجاد العلاقة بين داء السكري وسوفان المفاصل من خلال دراسة بعض المتغيرات الحياتية المشتركة بين المرضين مثل الفسفاتين واللبتين وهرمون النمو المشابه للانسولين... , وايضا دراسة تاثير داء السكري على تطور سوفان المفاصل. العينات, المواد وطرائق العمل : تضمنت هذه الدراسة (88)عينة مرضية من النساء فقط تراوحت اعمارهم (40 - 60) سنه ,في بداية التشخيص لمرض سوفان المفاصل من المصابين وغير المصابين بداء السكري الذين يعانون من السمنه)وقد تم جمع العينات من مستشفى الكاظمية التعليمي والمركز الوطني لبحوث وعلاج السكري / مستشفى اليرموك,من شهر ايار - تشرين الاول(2013 ) وقد تم تقسيم عينات المرضى الى ثلاث مجاميع وهي( مجموعة سوفان المفاصل وعددهم 24)و(مجموعة داء السكري وعددهم 20عينه)و(المجموعة الحاملة كلا المرضين عددهم 24عينه) فضلا عن مجموعة السيطرة وعددهم (20عينه) وقد تم تقدير مستويات الدوال في امصال العينات من خلال اجراء الفحوصات المختبرية التالية : هرمون الفس?اتين, هرمون االلبتين, هرمون النمو الشبيه بالانسولين - 1,مستوى الانسولين الصائم , هرمون المناسل المحفز الجربي FSH والمحفز للجسم الاصفر LH , مؤشر معصد البلازما بوساطه العلاقة اللوغاريتمية المتمثلة بالكسر المولي للدهون الثلاثية والدهون عالية الكثافة وفحص مقاومه الانسولين,وفحص السكر الصائم, الدهون في الدم وخضاب الدم المعسل والتي تم قياسها لجميع المرضى وافراد مجموعة السيطرة.النتائج : كانت النتائج المستحصلة من هذه الدراسة كما يلي : ? اظهر المستوى االمصلي للفسفاتين واللبتين وكذلك قيم مؤشر معصد البلازما زياده معنويه في مجاميع المرضى الثلاث وهي (داء السكري , سوفان المفاصل والذين يعانون كلا المرضين) بمجموعه السيطرة بمستوى احتماليه p< 0.05)),في حين لوحظ انخفاض معنوي لدى المرضى الذين يعانون من كلا المرضين (السكري والسوفان) في حالة اخذ الدواء مقارنة بالمرضى بدون دواء تحت احتماليه p< 0.05)).? اظهر المستوى المصلي لهرمون النمو الشبيه بالانسولين انخفاض معنوي في مجاميع المرضى الثلاث وهي (داء السكري , سوفان المفاصل والذين يعانون كلا المرضين) بمجموعه السيطرة تحت احتماليه p< 0.05)), في حين لوحظت زيادة معنوية لدى المرضى الذين يعانون من كلا المرضين (السكري والسوفان) في حالة اخذ الدواء مقارنة بالمرضى بدون دواء تحت احتماليه p< 0.05)), ووجد ايضا ان عامل العمر له تاثير " كبير جدا على قيم مؤشر معصد البلازما ومستوى الفسفاتين ,اللبتين وهرمون النمو الشبيه بالانسولين.? اظهر انخفاض معنوي في مستوى نسبة LH/ FSH في مجاميع المرضى الثلاث وهي (داء السكري , سوفان المفاصل والذين يعانون كلا المرضين) بمجموعه السيطرة تحت احتماليه p< 0.05)), في حين وجدت زياده معنوية في مستوى نسبة LH/FSH في مجموعة المرضى اللذين يعانون من كلا المرضين مقارنة بمجموعة مرضى السكري ومجموعة سوفان المفاصل ولوحدها. ? مستوى الفسفاتين يرتبط ايجابيا مع قيم مؤشر معصد البلازما في مجموعة مرضى داء السكري والمجموعة اللذين يعانون كلا المرضين تحت احتماليه p< 0.01)),في حين لايوجد ارتباط بين مستوى الفسفاتين وقيم مؤشر معصد البلازما في مجموعة مرضى سوفان المفاصل ومجموعة السيطرة. ? اظهر مستوى هرمون النمو الشبيه بالانسولين ارتباطا سلبيا مع قيم مؤشر معصد البلازما عند مجاميع المرضى الثلاثة ( داء السكري , سوفان المفاصل وكلا المرضين) تحت احتماليه p< 0.01)), لكن لايوجد ارتباط مع مجموعة السيطرة. ? اظهر مستوى اللبتين ارتباطا ايجابيا مع قيم مؤشر معصد البلازما عند مجاميع المرضى الثلاث ( داء السكري , سوفان المفاصل وكلا المرضين) تحت احتماليه p< 0.01)), لكن لايوجد ارتباط مع مجموعة السيطرة.? وايضا وجد ارتباط سلبي بين مستوى الفسفاتين ومستوى اللبتين عند المجموعة الحاملة كلا المرضين داء السكري وسوفان المفاصل تحت احتماليه p< 0.01)),في حين كان هناك ارتباطا ايجابيا بين مستوى الفسفاتين ومستوى اللبتين عند مجموعة السكري ومجموعة سوفان المفاصل ولوحدها تحت احتماليه p< 0.01)), وقد وجد ايضا ارتباطا سلبيا بين مستوى الفسفاتين ومستوى هرمون النموالشبيه بالانسولين عند مجاميع المرضى الثلاث تحت احتماليه p< 0.01)) , ولايوجد ارتباط مع مجموعة السيطرة. ? اظهر ارتباطا ايجابيا بين مستوى نسبة LH/FSH وكل من مستوى الفسفاتين , اللبتين وهرمون النمو الشبيه بالانسولين عند مجاميع المرضى الثلاث تحت احتماليه p< 0.01)), لكن لايوجد ارتباط في مجموعة السيطرة. الاستنتاج : نستنتج ان سوفان المفاصل له تاثير مباشر على بعض المؤشرات الحياتية مثل مستويات هرموني اللبتين والفسفاتين واختلال الدهون وقيم مؤشر معصد البلازما. ومن اهم النتائج ان الفسفاتين مؤشر جيد لدراسة تطور المرض ومن الممكن استخدامه كوسيلة للعلاج وكذلك نستنتج ان السيطرة على مستويات السكر عند مرضى سوفان المفاصل مهم جدا خلال العلاج وبالاخص لو تطلب الامر اجراء عملية جراحية.

تحضير، تشخيص وتقييم بايولوجي لبعض الادوية المصاحبة المشتقة من بعض مضادات الالتهابات غير الستيرويدية == Synthesis , Characterization And Biological Evaluation of Some Prodrugs Derived From Non - Steroidal Anti - Inflammatory Drugs (NSAIDs)

اسم المؤلف: مصطفى راجي عايد حمد
اسم المشرف: خالد مطني محمد الجنابي | اياد سعدي حميد الدليمي
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: الكيمياء الحياتية
الدرجة: دكتوراه
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: اجري هذا البحث لايجاد العلاقة بين العجز الكلوي المزمن ومستويات بعض المتغيرات الكيموحيوية عن طريق قياس مستوى انزيم الرينيين والفيوكوز الكلي (TF), الفيوكوز المرتبط بالبروتين (PBF) , البروتين المرتبطة بالسكريات السداسية (PBHex) وعدد من المتغيرات الكيموحيوية | This study has been done to determine the relationship between chronic renal failure and the level of some biochemical parameters (Rennin enzyme, Total Fucose(TF), Protein bound Fucose(PBF), protein bound Hexose (PBHex), and some other biochemical parameters including glucose , Urea, createnine, Uric acid, High density lipoproteins Cholestrol(HDL - c.), low density lipoproteins Cholestrol (LDL - c.) and electrolytes (Na+, K+ and Ca+2). Case study included (80) patients with chronic renal failure,Who admitted to the Kirkuk General Hospital Department of Dialysis , there ages were (31 - 60 years) of both sexes , patients has been divided into subgroups according to age {(31 - 35),(36 - 40),(41 - 45),(46 - 50),(51 - 550),(56 - 60)}year and severity compared with (45) normal persons as control with same ages, the results was as follows : Results showed a significant increase (P?0.01) in the level of rennin enzyme (5.013±0.052 ng/mL.h) of patients before dialysis compared with control group (2.58±0.32 ng/mL.h) for different age groups, and there was a significant increase slightly for different age groups.There was a significant increase (P?0.01) in the level of TF and PBF (12.14±0.89 mg/dL),(7.450±0.18 mg/dL) respectively compared with control group (28.76±0.03 mg/dL), (2.26±0.27 mg/dL) respectively for different age groups, and there was no significant correlation between age groups or sex.There was significant decrease (P?0.01) in the level of protein bound hexose PBHex, (123.35±0.9 mg/dL) compared with control group (89.76±0.9 mg/dl) for different age groups, and there was no significant correlation between age groups or sex.There was a significant increase (P?0.01) in the level of glucose (5.072±0.13 mmol/L) compared with control group (7.03±0.46 mmol/L) for different age groups, and there was a significant increase for females (7.40±0.7 mmol/L) compared with males (6.84±0.4 mmol/L).There was a significant increase (P?0.01) in the level of urea, uric acid and createnine, (5.66±0.24 mmol/L) , (336.5±1.4 mmol/L) , (90.8±1.3 mmol/L) respectively when compared with control group (34.27±0.9mmol/L) ,(516±1.8 mmol/L), (866±1.9 mmol/L) respectively for different age groups, and there was significant increase for males compared with females.There was a significant increase (P?0.01) in K+ level (5.896±0.05mmol/L) compared with control group (4.253±0.12mmol/L) and there was no significant correlation for males compared with females.There was a significant decrease (P?0.01) in Na+, Ca+2 level, (2.317±0.044 mmol/L), (144.35±1.6mmol/L) respectively compared with control group (1.89±0.046 mmol/L) , (121.00±1.1mmol/L) respectively and there was no significant correlation for different age groups or males and females, while there was a a significant correlation for male (1.979±1.1mmol/L) compared with female (1.768±0.073mmol/L).Result showed a significant decrease in HDL_c in the serum of patients before dialysis (1.263±0.027 mmol/L) compared with control (0.701±0.014 mmol/L) and there was a significant increase in HDL - c for female group compared with male group.There was significant increase in LDL_c in the serum of patients before dialysis (2.946±0.019mmol/L) compared with control (5.1±0.68mmol/L) and there was a significant increase in LDL - c for female (6.30±1.3 mmol/L) compared with male group(5.076±0.023mmol/L).

تحضير وتشخيص بعض مشتقات السكارين العضوية ومعقدات السكارين ومشتقاته الفوسفينية مع بعض الفلزات == Synthesis And Characterization Some of Organic Saccharin Derivatives And Metal Complexes of Saccharin And Its Phosphine Derrivative

اسم المؤلف: عفراء صابر شهاب الزوبعي
اسم المشرف: احمد عبد الحسن احمد الكاظمي | صبحي عطية محمود الجبوري
الموضوع العام: علوم الكيمياء
السنة: 2012
الموضوع الدقيق: الكيمياء العضوية
الدرجة: دكتوراه
الجامعة: جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: صلاح الدين
الصفحات الاولى:
المستخلص: تضمن البحث تحضير عدد من الادوية المصاحبة المشتقة من مضادات التهاب غير ستيرويدية تم الحصول عليها من معمل ادوية سامراء هي الايبوبروفين، الاندوميثاسين، النابروكسين، الاسبرين، الكابتوبريل والايزونوزايد. عملية تحوير ال | In this study, a number of prodrugs have been synthesized starting from Non - steroidal anti inflammatory drugs such as Ibuprofen, Indomethacin, Naproxen, Aspirin, Captopril and Isoniazid. The modification process started from the conversion of carboxyl group which is existing in these drugs (except in Isoniazid) into esters, chlorides and acid hydrazide.The drugs have been linked to each other and to itself via amide linkage through the reaction of their acid chlorides and acid hydrazides to afford 1,2 - diacyl hydrazine derivatives(M17 - M27). Some acid hydrazides have been treated with isophthaloyl chloride to Benzene - 1,3 - dicarbo hydrazide - 1,3 - Bis substituent(M28 - M30). The same hydrazides have been treated with Benzen - 1,3,5 - tri carbonyl tri chloride to afford Benzen - 1,3,5 - tricarbhydrazide - 1,3 - Tris substituent (M31 - M33). Compounds M28 and M29 have been treated with POCl3 to afford Bis - substituent - 5 - phenyl - 1,3,4 - Oxadizole(M34 - M35). Another modification onto drugs has been done through the linking of these drugs with quinazoline nucleus through amide linkage to afford N - (4 - oxo - 2 - phenylquinazolin - 3(4H) - yl)amide - substit derivatives (M38 - M42). Another modification has been carried out through the reaction of hydrazides with Aromatic aldehydes to afford the mono hydrazide - hydrazones derivatives or Schiff's bases (M43 - M65) and di hydrazide - hydrazones derivatives in which two moles from hydrazide have been treated with one mole of dialdehyde(M66 - M73). In addition, new hydrazones have been synthesized through the reaction of hydrazides with Isatin nucleus which is well known as biological active center to afford the compounds (M74 - M77) with good biological activity. Benzodiazepines have been obtained through the reaction of Isoniazid hydrazones with glycene phthalimide and p - aminobenzoic acid(M82 - M92). Indomethacin hydrazones have been treated with acetic anhydride to afford 1 - [2 - (substituent) - 5 - (5 - methoxy - 2 - methyl - 1H - indol - 3 - ylmethyl) - [1,3,4]oxadiazol - 3 - yl] - ethanone derivatives (93 - M97). The Derivatives of 5 - substit - 2 - Mercapto - 1,3,4 - Oxadiazole(M98 - M103) have been obtained through the reaction of the drug hydrazides with CS2 in the presence of KOH. The oxadizoles have been treated with hydrazine hydrate to afford 4 - amino - 5 - sub - 4H - 1,2,4 - triazole - 3 - thiol derivatives for the Non - steroidal anti - inflammatory drugs(M104 - M107). In addition, 5 - sub - 1,3,4 - Oxadiazole - 2 - amine derivatives have been obtained through the reaction of drug hydrazides with BrCN(M108 - M111). The compound 5 - {1 - [4 - (2 - methylpropyl)phenyl]ethyl} - N3 - phenyl - 4H - 1,2,4 - triazole - 3,4 - diamine (M113) has been synthesized through the reaction of the compound 2 - {2 - [4 - (2 - methylpropyl)phenyl]propanoyl} - N - phenylhydrazinecarbothioamide (M112) with hydrazine hydrate. The ester compound 2 - hydroxyphenyl 2 - [4 - (2 - methylpropyl)phenyl]propanoate (M114) have been obtained through the reaction of Ibuprofen chloride with salicylic acid. The two compounds, 2 - (4 - Isobutyl - phenyl) - propionic acid [1 - (4 - methyl - piperazin - 1 - ylmethyl) - 2 - oxo - 1,2 - dihydro - indol - 3 - ylidene] - hydrazide (M115) and 2 - (4 - Isobutyl - phenyl) - propionic acid [5 - fluoro - 1 - (4 - methyl - piperazin - 1 - ylmethyl) - 2 - oxo - 1,2 - dihydro - indol - 3 - ylidene] - hydrazide (M116) have been obtained through the reaction of M74, M77 with excess of formaldehyde and equimolar of N - methyl piperazine.The synthesized compounds have been identified using Infra - red spectroscopy FTIR, Nuclear Magnetic resonance (1H,13C), Mass spectroscopy and X - Ray. In addition , the changes in physical properties such as melting points, boiling points and color have been considered. Finally, the biological activity of some synthesized compounds has been evaluated and some of them have shown good biological activity especially those containing Isatin nucleus (M74 - M77) and (M115 - M116).

تحضير وتشخيص مشتقات جديدة للاندنول تحمل حلقات غير متجانسة متنوعة == Synthesis And Characterization of New Indole Derivatives Bearing Various Hetero Rings

اسم المؤلف: كاظم ماذي لازم العلياوي
اسم المشرف: جمبد هرمز توما | خالد فهد علي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء العضوية
الدرجة: دكتوراه
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تتضمن هذه الاطروحة تحضير وتشخيص بعض مشتقات السكارين العضوية ومعقدات السكارين ومشتقاته الفوسفينية مع بعض الفلزات، حيث استخدم سكارينات الصوديوم والسكارين كمواد اولية للتحضير وكما ياتي : 1 - حضر N - كلور اسيتل سكارين (A2) من تفاعل السكارين مع كلور استيل كلور | This thesis include synthesis and characterization of some organic saccharin derivatives and metal complexes of saccharin and its phosphine derivatives are synthesized in this work according to the following : 1. The N - Chloro acetyl saccharin (A2) is prepared from the reaction of saccharin with chloro acetyl chloride, in presence of Et3N in 1,4 Dioxan. The N - (2 - aryl amino) acetyl saccharine (A3 - A9) is synthesized from the reaction of compound (A2) with the substituted amin.The N - (2 - Saccharin - 2yl) acetyl saccharine A(10) is prepared from reaction of two mole saccharin with mole chloro acetyl chloride in presence of Et3N in 1,4Dioxin.2. Mannich Bases (A11 - A26) are prepared from the reaction of saccharin with substituted primary amin and fromaldehyde in methanol.3. N - Hydroxy methyl saccharin (A27) is prepared from the reaction of saccharin with formaldehyde in H2O or EtOH. The N - methylacetat saccharin (A28) is prepared from the reaction of compound (A27) with acetic anhydride in the presence of NaOH.4. (3 - Benzosulfonamide2 - Carboxylicacid2 - yl)2 - imino thiazolidin - 4 - (one) (A29) is prepared from the reaction of compound (A2) with KSCN in acetone.5. N - Benzoyl Saccharin (A30) is prepared from the reaction of saccharin with Benzoyl Chloride in acetone in the presence of NaHCO3.6. N - acetyl Saccharin(A31) is prepared from the reaction saccharin with acetyl chloride in DMF in the presence of Et3N also N - acetyl saccharin (A49) is prepared from the reaction of sodium saccharin with acetyl chloride in DMF. The N - acetyl saccharine is used in the preparation of ? - ? - Unsaturated carbonyl compounds(A50 - A54) through its reaction with substituted benzaldehyde , and also N - acetyl saccharin is used in the preparation of Schiff bass A(55 - 58) through its reaction with substituted amine.7. N - acetonyl saccharin (A32) is prepared from the reaction of sodium saccharin with chloro aceton in DMF. The N - acetonyl saccharin is used in the preparation of Schiff base A(33 - 38) through its reaction with substituted of amine and also N - Acetonyl saccharin is used in the.preparation.of? - ? - Unsaturated.carbonyl.compound(A39 - A45) through its reaction with substituted benzaldehyde.8. N - saccharinato acetic acid (A46) is prepared from the reaction of sodium saccharin with chloro acetic acid in DMF. The N - saccharinato acetic acid used in the preparation of 5 - (N - Saccharin) methyl )2 - amino - 1,2,3 thiadiazol (A47) through its reaction with thio semicarbazide in toluene and also N - Acetic acid saccharin is used preparation of N - ((1H - benzo[d]imidozol - 2yl)methyl) Saccharin (A48) through its reaction with O - Phenyl diamine.9. N - 3 - bromopropyl saccharin (A59) is prepared from the reaction of sodium saccharin with 1,3 dibromopropan in DMF.10. 2 - ChloroN - (4 - (2 - methaoxazol - 5yl)sulfamoyl)phenyl)acetamide (A60)is prepared from the reaction of4 - aminosulphamethaoxazol with chloroacetyl chlorid in 1,4dioxan in the presence of Et3N.2 - saccharin - N(4 - (2 - methyloxazol - 5yl)sulfamoyl)phenyl acetamide(A61)is.prepared from the reaction of sodium saccharin with (A6o)in DMF11. N - ethyl acetate saccharin A(62) is prepared from the reaction of sodium saccharin with chloro ethyl acetate in DMF. The N - acetic acid saccharin (A63) is prepared from the acidic hydrolysis of N - ethylsaccharin acetate by HCl , CH3COOH.The N - (acetyl thiosemicarbazide)saccharine(A64) is prepared from in the reaction of thiosemicarbazide with (A62)in acetone.The 5 - ((N - Saccharin )methyl) - 1,3,4 - thiadiaezol A(65) is synthesized in ring closur reaction by compound (A64) by sulfuric acid.12. N - Diphenyl phosphin saccharin (66) is prepared from the reaction of sodium saccharin with chloro diphenyl phosphine in dry ether. The N - diphenyl phosphin saccharin is used in the preparation of the complexe of the type [M CL2L2] , M=Pt(II) , Pd(II), Ni(II), L = Diphenyl phosphin saccharin [A70 - 72] through its reaction with Na2PdCl4 , PtCl2(DMSO)2,NiCl2 - 6H2O in CH2Cl2 or aceton in which N - Phenyl phosphin saccharin Ligands berhaves as amono dentat and coordinat through (P) atom to Metal.13. Aqua saccharin complexes of the type [M(Sac)2(H2O)4] 2H2O , (M=Ni,Co,Fe,Zn,Mn,Cd,Cu)(A73 - 79) are prepared from reaction sodium saccharin with divalent metal ions from (Ni,Co,Fe,Zn,Mn,Cd,Cu) in which saccharin Ligands behave amono dentate and coordinate through (N) atom to metal.Treament of (dppe , dppm) with aqua saccharinat complexes(A80 - A88) in CH2Cl2 gave complexes of this type.The treatment of dppe with aqua saccharinat complexes of the (Cd,Zn,Fe,Mn)(A79,A78 ,A76,A75)give complexes (A80 - A83)of this type [M(Sac)2(dppe)2], the dppe in these complexes coordinate as abidentate. but treatment of dppe with aqua saccharinat of the (Ni,Co)(A73,A74) gave complexes (A84,A85)of this type [M(Sac)2(dppe)], but treatment of dppe with aqua saccharinat complexes of the (Cu)(A77) , gave complexes(A86) of this type [Cu(Sac)dppe]. The treatment of dppm with aqua saccharinato complexes of the (Cd,Zn)(A78,A79) gave complexes (A87,A88) of this type [M(Sac)2(dppm)2].The structure of the synthesized compound are confirmed by I.R , H1 - N.M.R,C13 - N.M.R,Elemental analysis , molar conductivity and some chemical physical data.

تحضيروتشخيص بعض المشتقات الجديدة لثنائي هيدروبريميدينون باستخدام تفاعل بكينيلي ودراسة فعاليتها البايلوجية == Synthesis And Characterization And Biological Activity Study of Some New Dihydropyrimidinones Derivatives Via Application Biginelli Reaction

اسم المؤلف: احمد ماهر فهيم
اسم المشرف: نبيل عبد عبد الرضا
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: دكتوراه
الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: The present work involved synthesis of new indole derivatives containing other heterocyclic ring. These derivatives could be divided into the following parts : 1. The first part involved synthesis and characterization of novel 1,3 - diazidine[XIII]a - d and [XIV]a - d by the following steps : Scheme(1).a. Synthesis of 3 - [(5 - hydrazinyl - 4 - phenyl - 1,2,4 - triazol - 3 - yl)methyl] - 1H - indole [VI], this compound is synthesized by neucleophilic substitution reaction of 1,2,4 - triazole - 5 - thiol compound [V]a with excess of hydrazine hydrate in absolute ethanol as a solvent.b. Synthesis of 2 - {5 - [(1H - indol - 3 - yl) - propyl] - 4 - phenyl - 1,2,4 - triazol - 3 - yl} - thio - acetohydrazide[VIII]b, by the reaction of ester compounds[VII]b with excess of 80% hydrazine hydrate in ethanol under reflux.c. Synthesis of new Schiff bases[IX]a - d and [X]a - d by condensation reaction of primary amino compounds[VI] or [VIII]b with different aromatic aldehyde in absolute ethanol as a solvent.d. Synthesis of new N - acyl derivatives[XI]a - d and [XII]a - d by reaction of acetyl chloride with the synthesized Schiff bases[IX]a - d, [X] a - d in dry benzene.e. Synthesis of 1, 3 - diazetine derivatives[XIII]a - d and [XIV]a - d by addition reaction of compound[XI]a - d or [XII]a - d with sodium azide in dimethylformamid as a solvent at (55 - 60)0C temperature.2 - While the second part involved synthesis and characterization of novel thiazolidine - 4 - one compounds[XXI]a - d and [XXII]a - d by the following steps : Scheme(2).a. Synthesis of 2 - [5 - (2 - methyl - 1H - indol - 3 - yl) - 4H - 1,2,4 - triazol - yl] - thio - ethyl hydrazide[XVIII] by the reaction of ester compound[XVII] with excess of 80% hydrazine hydrate in ethanol under reflux.b. Synthesis of 2 - {5 - [(1H - indol - 3 - yl) - methylene] - 4 - phenyl - 1,2,4 - triazol - 3 - yl} - IXthio - ethylhydrazide[XVIII], by the reaction of ester compounds[XVII] with excess of hydrazine hydrate in ethanol under reflux. Also synthesize new Schiff bases [XIX]a - d and [XX]a - d by condensation reaction of acid hydrazide compounds [VIII]a or [XVIII] with different aromatic aldehyde in absolute ethanol as a solvent.c. Synthesis of new thiazolidine - 4 - one derivatives, [XXI]a - d and [XXII]a - d by refluxing equimolar amounts from Schiff bases[XIX]a - d and [XX]a - d with excess of thioglycolic acid in dry benzene.3. The third part involved synthesis and characterization of new series of thiazolidine - 4 - one [XXVII]a - c and [XXVIII]a - c by many steps reaction as follows : Scheme(3).a. Synthesis of new Schiff [XXIII]a,b, [XXIV]a,b by condensation reaction of acid hydrazide [III]a,b with two types of aromatic aldehyde in absolute ethanol.b. Synthesis of another type from thiazolidine - 4 - one derivatives [XXV]a, b and [XXVI]a, b from the reaction of Schiff bases [XXIII]a,b, [XXIV] a,b with excess of thioglycolic acid in dry benzene. The alkoxy derivatives of compounds [XXVII] and [XXVIII]; 2 - (4 - N - alkoxyphenyl) - 3 - (2 - methyl - 1H - indol - 3 - yl)amido - 1,3 - thiazolidine - 4 - one[XXVII]a - c and 2 - (4 - N - alkoxyphenyl) - 3 - (1H - indol - 3 - yl) acetamido - 1,3 - thiazolidine - 4 - one [XXVIII]a - c were synthesized by the reaction of terminal OH group of compound[XXV]a or [XXVI]a with different n - alkyl bromide in alkaline media.4 - The fourth part involved synthesis and characterization of amide derivatives of 1,3,4 - thiadiazole[XXXI]a - d, [XXXII]a - d and [XXXIII]a - d by the following steps : Scheme(4)a. Preparation of 2 - amino - 5 - (2 - methyl - 1H - indol - 3 - yl) - 1,3,4 - thiadiazole[XXIX] by cyclization reaction of 2 - (2 - methyl - 1H - indole - 3 - carbonyl) hydrazine carbo - thio amide [XV] in conc. H2SO4 under reflux followed by neutralized with liquid ammonia. While 2 - amino - 5 - [(1H - indol - 3 - yl)methyl] - 1,3,4 - thiadiazole[XXX]aand 2 - amino - 5 - [(1H - indol - 3 - yl)propyl] - 1,3,4 - thiadiazole[XXX]b synthesized by cyclization reaction under reflux of indole - 3 - acetic acid or indole - 3 - butric acid with thiosemicarbazide in the presence of phosphorous oxychloride.b. Synthesis of new amide derived from 2 - amino - 1,3,4 - thiadiazole [XXXI]a - d, [XXXII]a - d and [XXXIII]a - d from the reaction equimolar of suitable 2 - amino - 1,3,4 - thiadiazoles[XXIX] and [XXX]a,b with different acid chlorides in DMF and pyridine as accepter.5. The fifth part involved synthesis and characterization of new hydrazones [XXXVII]a - d and [XXXVIII]a - d. These compounds were synthesized according to the follows steps : Scheme(5)a. Synthesis and characterization of 1 - (2 - methyl - 1H - indole - 3 - yl) carbonyl - 3 - methyl - pyrazol - 5(4H) - one[XXXIV] and 1 - [(1H - indol - 3 - yl) ethanoyl or butanoyl] - 3 - methyl - pyrazol - 5(4H) - one [XXXV]a, b by heating under reflux a solution of equimolar from acid hydrazides[III]a - c with ethylacetoacetate in absolute ethanol.b. Synthesis and characterization of 1 - [4 - acetyl - (1H - indol - 3 - yl)ethanoyl or butanoyl] - 3 - methyl - pyrazol - 5 - one [XXXVI]a, b through reaction of pyrazolone derivatives[XXXV]a,b with acetyl chloride in 1,4 - dioxane in presence of calcium hydroxide.c. Synthesis and characterization of novel hydrazones [XXXVII]a - d and [XXXVIII]a - d by the reaction of 4 - acetyl - pyrazolone compounds[XXXVI]a, b with phenyl hydrazine or substituted phenyl hydrazine in ethanol.The synthesized compounds have been characterized by their melting points, elemental analysis (C.H.N) and by their spectral data, FTIR, 1HNMR and Mass spectroscopy (of some of theme).Study of the biological activity of some of the synthesized compounds against Gram - positive bacteria (Staphylococcus aureus) and Gram - negative bacteria (Escherichia coli). The results showed that most of the tested

دراسة مركبات الاوزميوم العنقودية باستخدام كيمياء الكم == Quantum Chemical Studies of Osmium Clusters

اسم المؤلف: احلام حسين حسن
اسم المشرف: محسن عبود محسن العبادي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء العضوية
الدرجة: ماجستير
الجامعة: جامعة الكوفة - كلية التربية - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: النجف
الصفحات الاولى:
المستخلص: تضمنت هذه الدراسة تحضير عدد من المشتقات الجديدة للدايهيدروبريميدينون والكوينزولينون وذلك من خلال عدة مسارات. المسار الاول تم تحضيرالمركبان (86,85) بعملية البنزلةbenzylation) ) والسلفنةsulfonation) ) لمشتق الالديهايد(4 - هيدروكسي بنزلديهايد) لانتاج الديه | The studies involves synthesis some new derivatives for the ( 3 , 4 dihydropyrimidin - 2(1H) - ones) by many schemes. The first Scheme involve synthesis compounds (85,86) by Benzylation and Sulfonation for aldahyde derived (4 - Hydroxybanzaldahyde) to give aldahydes larger and treatment in Biginelli reaction. The second Scheme includes preparation of derivatives(87 - 99) by Biginelli reaction for treatment different derivatives aldahydes with Ethylacetoacetate or Acetylacetone and Urea Catalyzed by Hydrochloric acid to give ( 3 , 4 dihydropyrimidin - 2(1H) - ones) The third Scheme includes preparation of Quinazolinone compounds (100 - 105) via reaction Cyclohxanone , Aldahyde derivativesand Urea Catalyzed by tributylborate in methanol as solvent. The last Scheme is treatment compound(90) is contan ketone group and a product via Biginelli reaction with primary amines such as p - toluidine and phenylhydrazine to give new Schiff base , also treatment compound(90) with diffrents aldehyde to give of pyrimidine compounds it is contan of Chalcones. As well as the thesis which us discussed the preparation and identification of newdihydro pyrimidine derivatives from throough spectra (I.R) , (1H - NMR) , (C13 - NMR) , (C.H.N) , specta (HSQC) , (COSY) and (HMBC). For some of these compounds, and these identification studies approved the correctness of the chemical structures for the prepared derivatives The study of biological activity of some of the synthesized compounds which were applied on bacteria of negative and positive gram formula showed that some of the studied compounds possess medium retardation activity against these bacteria.

تحضير دقائق مغناطيسيه متناهيه الصغر (نانو) ودراسة تقييدها لانزيم الزانثين اوكسيديز == Prepared of Magnetic Nanoparticles And Study The Immobilized For Xanthine Oxidase

اسم المؤلف: مصطفى محمد كريم
اسم المشرف: حسين كاظم الحكيم
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة الكوفة - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: النجف
الصفحات الاولى:
المستخلص: The purpose of this thesis is to report quantum chemical investigations into a series of problems related to contemporary organometallic chemistry. In recent years density functional approaches have become the most commonly used theoretical methodology in organometallic chemistry. Alongside these developments, a number of new tools for analyzing electronic structure such as topological analysis of electron density (Atoms in Molecules theory) have emerged. As a result, theory is now in a position to compute ab initio many of the experimental observables that underpin modern organometallic chemistry.The bonding in the Triosmium carbonyl cluster 1 [Os3(? - H)(? - ?2 - dpa - N,N)(CO)10] and Triosmium carbonyl cluster 2 [Os3( ? - H)2(NHC)(CO)9] are explored using the Quantum Theory of Atoms - in - Molecules (QTAIM). The metal - metal and metal - ligand bond critical points properties ?(r), ?2?(r), H(r), G(r), V(r) and ellipticity, and also the bond delocalization indices ?(A, B), are correlated with the data from previous studies of the organometallic systems. These results have allowed a comparison between topological properties of different atom - atom interactions. In the core of dihydride triosmium cluster 2, Os3H2 part, the topological data recognizes the existence of a bond path in the dihydride bridged Os atoms, Os(1) - Os(3) edges, whereas in monohydride triosmium cluster 1 there is no direct bond path has been found for the interaction between the hydride bridged Os atoms, although a non - negligible delocalization index ?(Os(1)...Os(2)) has been obtained for this non - bonding interaction. A multicenter 4c - 4e interaction is proposed to exist in the core part, Os3H, in cluster 1 and bridged part, Os(1) - H(1) - Os(3) - (H2) in cluster 2. In addition, an interaction of 5c - 5e type is proposed to exist in the core part, Os3H2. All topological parameters calculated for the Os - N and Os - C bonds between the osmium atoms and the pyridyl and NHC ligands in compound 1 and 2, respectively, are similar, and they confirm that these interactions are pure ? bond. The analysis of the topological parameters of the NHC and pyridyl ligands bonds confirm the existence of ? - electron delocalization within the six - membered ring of pyridyl ligand and hindered ? - electron delocalization within the five - membered ring of NHC ligand with some double - bond character in the interaction of the carbine C atom with the adjacent N atoms.

دراسة الخواص الميكانيكية لخلائط المطاط الطبيعي باستخدام انواع مختلفة من البوليمرات والمالئات == Study of Mechanical Properties For Natural Rubber Blends Using Different Types of Polymers And Fillers

اسم المؤلف: قصي خزعل موجر
اسم المشرف: محمد علي مطر
الموضوع العام: علوم الكيمياء
السنة: 2005
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: تم تحضير مركبات نانو مغناطيسية جديدة باستخدام الكوليستيرول والسلفادايزين مع اوكسيد الحديد المغناطيسي. حضرت هذه المركبات باستعمال طريقة الترسيب المشترك لاوكسيدي الحديد الثنائي والثلاثي ومن ثم ربطه بالحامض بطريقة فوق الاشباع. تم تشخيص المركبات المحضرة بالطر | Two new magnetic nanoparticles (MNPs) were prepared using magnetic iron oxides with cholesterol and sulfadiazine. These compounds were prepared by iron oxide (II and III) co - precipitation, and then the prepared MNP were incubated with cholesterol and sulfadiazine. The synthesized compounds were identified using multiple techniques, including transmission electron microscopy, scanning electron microscopy, diffractive light scattering, and thermogravimetric analysis. Results demonstrated the formation of new magnetic nanoparticles, namely, MNP@Cholesterol and MNP@Sulfadiazine. The interaction between the prepared MNPs and xanthine oxidase (XO) was evaluated as a potential method for the inhibition of the enzymatic activity. The inhibition of XO is an important issue to reduce the formation of uric acid, which is responsible for gout and kidney stone formation. Another potential application is the extraction of the XO enzyme from biological fluids, such as blood, or the immobilization of XO on the surfaces of MNPs as a new application of these insoluble particles.The interaction studies involved the incubation of XO solution with the suspension of prepared MNPs using XO solutions with different concentration and fixed MNP mass. The adsorption studies of XO on MNPs showed that the prepared MNPS can extract suitable amounts of XO from a solution. Slight differences in the XO quantities adsorbed on different MNPs were found. Adsorption isotherms followed the Sips equation, indicating slight heterogeneity in the adsorption active forces on MNPs. Circular dichroism study of the XO adsorption on the prepared MNPs showed significant changes in the secondary structures, namely, reduction of the ? - helix structure. Furthermore, fluorospectrophotometric studies showed changes in the tertiary structure of the XO caused by the interaction with the active sites of the prepared MNPs. The study of the inhibition of XO activity by the prepared MNPs showed mixed inhibition as a result of the changes in the original XO enzyme after interaction with the surfaces. Magnetic Fe3O4 showed the highest inhibition activity, followed by MNP@Sulfadiazine and MNP@Choleterol - XO.

التحضير والتشخيص الطيفي ودراسة الفعالية البايولوجية لليكاندي البنزاميدازوليل ازو غير متجانسي الحلقة الجديدين وبعض من معقداتهما الفلزية == Synthesis, Spectral Characterization And Biological Activity Study For New Heterocyclic Benzimidazolyl Azo Ligands And Their Metal Complexes

اسم المؤلف: بان عدنان حاتم
اسم المشرف: خالد جواد العادلي
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: نتيجة للتقدم العلمي الحاصل في مجال صناعة البوليمرات ظهرت الحاجة الى مواد بوليميرية بمواصفات معينة لا يمكن الحصول عليها من نوع واحد من البوليمرات , لذا كانت هناك محاولات لمزج نوعين او اكثر من البوليمرات للحصول على مزيج بوليميري بمواصفات صناعية مرغوب فيها و| As a result of scientific progress made in the field of polymer industry emerged the need for materials polymers with certain features has emerged can not be obtained from one type of polymers, so there have been attempts to blend two or more polymers for combination Self - leveling industrial specifications undesirable and the formation of a physical blends has the common characteristics of basic materials, and this depends on the type of polymers and blending mode. This study included the preparation Ajanta blends of natural rubber with thermoplastics, as follows : 1. Prepare Ajnat of natural rubber by (100phr) has been reinforced and the usual filers used black carbon types (HAFN330, ISAFN220, SAFN110) and adopted ratios (60,50,40,30,20,10 phr), and the results show that the increase in the content of black carbon leads to an increase in the mechanical properties (tensile strength, elastic modulus, hardness) and a decrease in (elongation at break and compressibility), and that the best ratio add was when (50phr) of all kinds of black carbon the study found that the best values of the properties of the species used from black carbon at (50phr) of type (SAFN110).2. Prepare Ajnat of natural rubber by (100phr) has been reinforced and enhanced using filer Nano (black carbon Nano, titanium dioxide Nano) rates (6,5,4,3,2,1 phr) and found that the increase during the study nano filers content leads to an increase in the mechanical properties (tensile strength, elastic modulus, hardness) and a decrease in the elongation at break and compressibility add that the best ratio was (5phr) of all kinds nano filers used. .3. Prepare Ajnat blends of natural rubber with thermoplastics (PP, PE, PS, PVC) adopted the blending ratios (55 / 45,70 / 30,85 / 15 phr), and the study found that an increase in plastics content leads to an increase in the hardness and low in compressibility, has been shown that the best mechanical properties (tensile strength, elastic modulus, elongation, and hardness, and compressibility) was when the proportion of blending (85phr) of natural rubber with (phr 15) of (PP, PS, PVC) and the proportion of blending (70phr) of natural rubber with (30phr) of (PE).4. The results of chemical analysis tests showed that blends prepared characterized by good resistance to chemical solutions (acids and bases) and a decrease in the degree of intumescent greater thermoplastics content ratio of(15phr) to (45phr) Ajnat in combination.5. The results show that the natural rubber blends with polyethylene showed chemical properties and good resistance to chemical solutions best compared with the plastics used in the preparation Ajnat.6. Determine compatibility blends by using technology (DSC) for blends prepared.

تحضير وتشخيص ليكاندات ازو جديدة غير متجانسة الحلقة مشتقة من 5,4 - ثنائي فنيل اميدازول ومعقداتها مع بعض الايونات الفلزية == Synthesis And Characterization of New Heterocyclic Ligands Based On 4,5 - Diphenyl Imidazole And Their Complexes With Some of Metal Ions

اسم المؤلف: اسراء نور كاظم وتوت
اسم المشرف: حسين عبد محمد صالح
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية العلوم - قسم الكيمياء
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: تضمن العمل تحضير ليكاندين جديدين من ليكاندات الازو العضويه غير المتجانسه المشتقة من البنزامبدازول الاول هو اليكاند 2'] - 2 - (بنزايميدازوليل) ازو [ - 6,4 - ثنائي كلورو فينول Benzimidazolyl) Azo] - 4,6 - dichloro phenol (BIADClP)) 2 - [2' - والليكاند الثا | This study deals with the preparation of two new ligands from the heterogeneous organic azo ligands drived from Benzimidazol.The first) 2 - [6 - Benzimidazolyl) Azo] - 2,4 - dichloro phenol (BIADClP). The second is 2 - [6 - (benzimidazolylazo)] - 2,4 - dibromo phenol(BIADBrP).The heterogeneous chain in both ligands includes two nitrogen atoms. These two ligands have been identification by the proton nuclear magnetic resonance spectra (1H - NNMR) ,the mass spectrum, infrared, visibale ultraviolet as well as the analysis of the micro - elements (C.H.N).And two new series of the solid canine complexes for these ligands. The first series includes six solid complexes of the ligand (BIADClP) with the metallic ions Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II). The second series includes the preparation of six solid complexes of the ligand (BIADBrP) with the metallic ions mentioned above. The effect of the solvent and the complexes stsbility have been studied on the prepared ligands with the passage of time starting from the moment of the metallic ion solution reaction with the ligand solution and up to 170 minutes. Also, the stability constants for these complexes have been calculated spectrally by visbale - ultraviolet spectra.All results show that these complexes have high stability. The infrared spectra of the prepared complexes have been studied and when compared with the free ligand spedtra give obvious changes as these spectra show new bands not already found in the spectra of both ligands and this is due to the occurance of the correlation between the metallic ions under study with the donar atoms [the nitrogen atom azo group near the heterogeneous chain (N3) and nitrogen atom benzimidazole molecule (N3) , the oxygen atom of hydroxyl group in the heterogenous chain ] in the ligand molecule whereas the other band suffered from obvious changes in shape, intensity and location and this is a proof on the occurance of consistency process between the metallic ions under study and the tow ligands. Atomic absorption spectrometer is used for assigning percentages of the metallic ions in the prepared complexes as well as the analysis of micro - elements (C.H.N). These results indicate the great consistency between the percentages theoretically calculated and practically gained. The magnetic sensitivity indicated that Ni(II) - complex and Cu(II) - complex for both ligands have baramagnatic characteristics whereas the Co(III) - complex, Zn(II) - complex, Cd(II) - complex, Hg(II) complex have adia magnetic characteristics. Also , the study deals with the molar conductivity of the canine complexes dissolved in DMF nad ethanol in a concentration (1×10 - 3) molar and in lap temperature. The results show that the complexes of Ni(II) , Cu(II), Zn(II), Cd(II), Hg(II) do not have ionic characteristics and they are solution of non - electrolytes nature whereas the complexes of Co(III) and for both prepared ligands (BIADClP) and (BIADBrP) have ionic characteristics of the electrolytes nature of type (1 : 1) whereas other remaining complexes do not have any ionic characteristics. Throughout the results that have been reached at, certain structural forms for the canine complexes have been suggested.It has been indicated that the azo Benzimidazol ligands under study behave as tridentate ligands where the consistency happens through the N atom benzimidazole chain (N3) and N azo group far from the heterogeneous chain (N3) oxygen hydroxyl group of the homogeneous chain which leads to forming canine hexagonal complexes having octahydral as steric form.The hybridization of these complexes is d2sp3 concerning Co(III) - complexes of the ligands (BIADClP) and (BIADBrP) whereas the other complexes have the hybridization sp3d2 with the tow prepared ligands under syudy. Moreover, the study deals with the biological activity of these ligands and metallic complexes in the growth of four types of bacterial spores (germs) by using the solvent DMSO and deployment technology as anti - bacterial such as Staphylococcus aureuse and Staph.lentus representative for Gram positive bacteria and enterobacte and Escherichia coli representative for Gram negative bacteria. It is found that ligands and there complexes have different effect as antidepressants in the inhibition and the growth of bacteria under study wheras the ligand (BIADClP) gave the ability in inhibition of the growth of bacteria more than the ligand (BIADBrO) this is due to the change of substituted group on the homogeneous chain and their different in both ligands which led to the emergence of such difference in the inhibition and growth of bacteria.

تخليق وتشخيص ودراسة الخصائص التفلورية والمضادة لفايروس نقص المناعة المكتسبة لبعض مشتقات البركنينولون الجديدة == Synthesis, Characterization, Fluorescence Properties, Anti - Hiv Activity And Molecular Modeling Study of Some New Pregenolone Derivatives

اسم المؤلف: رواء علاوي كاظم القريشي
اسم المشرف: نجم عبود لعيبي المسعودي | نبيل عبد عبد الرضا
الموضوع العام: علوم الكيمياء
السنة: 2015
الموضوع الدقيق: الكيمياء
الدرجة: دكتوراه
الجامعة: جامعة القادسية - كلية العلوم - قسم الكيمياء
اللغة: العربية
النص الكامل من المصدر: https://qu.edu.iq/repository/wp-content/uploads/2017/04/%D8%A7%D9%84%D8%AC%D8%B2%D8%A1-%D8%A7%D9%84%D8%A7%D9%88%D9%84-%D9%85%D9%86-%D8%A7%D9%84%D8%B1%D8%B3%D8%A7%D9%84%D8%A9.pdf
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: نظرا لما تتمتع به مركبات الازو من تطبيقات مهمة في كل من المجالين الاكاديمي والتطبيقي فقد تمحورت دراستنا على تحضير ستة ليكاندات ازو جديدة مشتقة من المركب 5,4 - ثنائي فنيل اميدازول ودراسة السلوك التناسقي لكل منها مع ستة ايونات فلزية هي Co(II) , Ni(II) , C | Azo compounds have important applications in both of academic and applied fields, Accordingly, our study based on the synthesis of azo compounds derived from 4,5 - diphenyl imidazole and characterization of these azo compounds with their metal complexese containing Co(II) , Ni(II) , Cu(II) , Zn(II), Cd(II) and Hg(II) ions. Mass Spectra of ligands and their complexes were supported their molecular formula, while H1NMR spectra of ligands agreed well with the suggested structures , The C.H.N. and Atomic absorption analysis showed a good agreement with the calculated values , The purity of ligands and their complexes were examined by TLC and the values of Rf were values measured.Electronic spectra of complexes showed a bathochromic shift comparing to ligands spectra as a result of the coordination between the metal ions and ligands. The concentrations that obeyed Beer - Lambert Law of the complexes were determined from calibration curves , Mole Ratio Method indicate a ratio (1 : 2) (Metal : ligand) for the complexes of (DPEPI) and (DPDED) while other complexes with other ligands show a ratio (1 : 1) (Metal : ligand).Satiability Constants of the complexes were calculated and found that the Stability constants of complexes of the first ligand (DPEPI) were ( 2.955×10 12) >(2.294× 1011 ) <(1.121×10 12 ) < (1.108 ×1011 ) varied in the arrangement as Co(II)< Ni(II) < Cu(II)> Zn(II) which agree with Irving - Williams Series. This arrangement was applied on the complexes of the other ligands. The Conductivity measurements of complexes showed non ionic character. Apparently the magnetic susceptibility values agree with their values of the octahedral high spin complexes for Co(II)) while the complexes of Zn(II), Cd(II), and Hg(II) were diamagnetic. IR Spectra of complexes showed obvious changes of the frequencies of ? (N=N) of azo group and ?(C=N) of heterocyclic imidazole ring as result of coordination with metal ions, While the frequencies of ?(C=N) of azomethine group did not show any significant change for complexes comparing to the ligands spectra ,New bands were appeared in the region (400 - 500) cm - 1 in the spectra of complexes that due to frequencies of ?(M - N) because of coordination process. From the previous results the purposed structures of the complexes can be summarized as shown in the following : Proposal structure of (DPEPI) Complexes Proposal structure of (DIDHP), (DIDMP),

دراسة حركية لتاثير بعض المركبات المخفضة للدهون الثيازينات والثياديازول على الكرياتين كاينيز و3 - هيدروكسي - 3 - مثيل كلوتاريل كو انزيم - اي ريدكتيز في امصال مرضى ارتفاع الدهون والفئران المختبرية التي تم حث ارتفاع الدهون فيها == Kinetic Study of The Effect of Some Novel Lipid Lowering Thiazines And Thiadiazole Compounds On Creatine Kinase And 3 - Hydroxy - 3 - Methyl - Glutaryl - Coa Reductase Activities In Sera of Hyperlipidemia Patient’s And Wister Mice With Induced Hyperlipide

اسم المؤلف: تمارة احمد عبد الكريم العبيدي
اسم المشرف: زينب منيب مالك الربيعي | غيد حسان عبد الهادي العبيدي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تمثل الستيرويدات فئة هامة من العقاقير الطبيعية وكذلك الصناعية نظرا لقدرتها على اختراق الخلايا واداء بعض الوظائف البيولوجية الاساسية وبشكل رئيسي هي عوامل مضادة للفيروسات ومضادات للاورام. وتقسم الرسالة الحالية على ثلاثة فصول.يمثل الفصل الاول مقدمة عامة حو | Steroids represent an important class of natural as well as synthetic drugs because of their ability to penetrate cells and perform some of the most fundamental biological functions mainly as antitumor and antiviral agents. The present thesis is devided into three chapters.The first chapter represented a general introduction concerning the structures of some potent steroids, and the pathways of the synthetic adrenal steroids as well as their pharmacological importance in medicine, in general. This part is focused mainly also on the pregnenolone as an important potentially active steroid, including its structural modification at the hydroxyl and keto groups at C - 3 and C - 20 and their uses as antitumor agents. Mitsunobu, Suzuki reactions and aldol condensation as well as chalcon formation and their application at steroids have been described. The second chapter is concerned with the experimental work which included different synthetic methodology.The third chapter is the main part of the thesis, described the synthesis of new 3? - pregnenolone ester derivatives at C - 3 via Misunobu reaction of the carboxylic acid derivatives, such as : rhodamin B, indomethacin, naproxen, protocatecuic acid, vanillic acid and p - coumaric acid, which showed inversion in configuration at the ester group at C - 3. In addition, the synthesis of 17 - (4 - chloro - chalconyl)pregnen - 3? - ol has been described, which then treated with various substituted phenylboronic acids such as : 2,4 - difluoro - , 5 - carboxy - 3 - nitrop - ,4 - fluoro, 4 - thiomethyl - , 4 - hydroxy - , 2,4, - dimethoxy - , 4 - trimethylsilyl, 2 - triflouromethyl - , 3 - cyano, 4 - ethoxyphenyl boronic acids under Suzuki cross - coupling reaction conditions using Pd(PPh3)4 as a catalyst and Na2CO3 as a base to give the (E) - 3 - (substituted - [1,1’ - biphenyl] - 4 - yl) - 1 - (3? - hydroxy - pregnen - 17 - yl) - prop - 2 - en - 1 - one. Two compounds, 17 - acetyl - 5 - pregnen - 3? - yl) - 2 - (2,6 - bis(diethylamino) - 9H - xanthen - 9 - yl)benzoate, and 17 - ((E) - 3 - (4 - chlorophenyl)acryloyl) - 5 - pregnen - 3? - yl) - 2 - (2,6 - bis(diethylamino) - 9H - xanthen - 9 - yl)benzoate have been synthesized via coupling reaction using DCC as a coupling reagent to afford these ester with retention in configuration, aiming to study their fluorescence properties. Moreover, tritylation of the pregnenolone has been described to protect the alcohol at C - 3 during the structural modification of keto group at C - 20 under basic medium. The structures of all the synthesized compounds have been assigned from their 1H, 13C, and 2D NMR (HSQC, HMBC, COSY, NOESY) spectroscopy as well the as theoretical calculations of the HOMO and LUMO energies of the trans and cis isomers of the chalconyl pregnenolone aryl derivatives to compare them with the NMR data, which showed that trans isomer is energetically more favoured.Furthermore, the flourescence proroperties of the two rhodainyl pregnenolone esters have been studies which one show remarkable quantum yield (?F) in comparison to Rhodamin B itself.The anti - HIV activity of some arylated chalconyl pregnenolone derivatives have been studies and one of these analogues having diflouro substituents exhibited remarkable activity against HIV - 1 and 2. Therefore, the molecular modeling study of this analogue is performed and showed two hydrophobic interactions and one hydrogen bonding with the amino acids residues of the reverse transcriptase enzyme of HIV.

تحسين حماية التاكل للمعادن (الخارصين، النحاس، الالمنيوم، الحديد الكربوني والحديد المقاوم للصدا 316) في ماء البحر الصناعي باستخدام الطلاء بالمواد النانوية == Corrosion Protection Enhancement Of; Zn, Cu, Al, Carbon Steel And Stainless Steel 316 In Artificial Seawater By Coating With Nanomaterials

اسم المؤلف: رائد عبد شاكر محمود
اسم المشرف: عبد الكريم محمد علي جبر السامرائي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الهدف من هده الدراسة هو تقدير تاثير بعض مشتقات الثياديازول والثيازين الجديدة التحضير على فعالية كل من الانزيمين الكرياتين كاينيز و3 - هيدروكسي - 3 - مثيل كلوتاريل كو - انزيم اي ريدكتيز بالاضافة الى قياس صورة الدهون في مرضى ارتفاع الدهون والفئران المختبرية | The aim of this study is to evaluate the effect of some novel prepared derivatives of thiadiazole and thiazine on the activities of creatine kinase (CK) and 3 - hydroxy - 3 - methylglutaryl CoA reductase(HMGR) in addition to lipid profile in sera of hyperlipidemic patients and in mice induced hyperlipidemia by feeding cholesterol rich diet.The study includes two parts; in vitro study : Sixty individuals with age ranged between (40 - 60) years were enrolled in this study. They were divided into two groups; first group (G1) consists of 30 healthy individuals as a control group with body mass index (BMI) (25.67). The second group (G2)consists of 30 patients with hyperlipidemia and BMI (26.48) which diagnosed by physician. The patients attended the Ibn - Al Naphes hospital during November 2013 to February 2014. Patients with high blood viscosity, diabetes mellitus, renal failure as well as those who are under treatment with statins were excluded. The serum which obtained used in the determination of lipid profile[total cholesterol(Tch),triglyceride(TG), high density lipoprotein(HDL - c), very low density lipoprotein(VLDL - c)], fasting blood glucose(FBG), aspartate transaminase (AST), alanine transaminase(ALT) and C - reactive protein(CRP).Four organic compounds 3 - (4 - (dimethylamino) phenyl) - 2,3 - dihydro - 2 - (3 - nitrophenyl benzo[1,3 - e]thiazin - 4 - one[I], 5 - (4 - imethylamino)benzylideneamino) - 1,3,4 - thiadiazole - 2 - thiol[II], 2 - (4 - dimethylamino)phenyl) - 2,3 - dihydro - 3 - (5 - mercapto - 1,3,4 - thiadiazol - 2 - yl)benzo[1,3 - e]thiazin - 4 - one[III], and N - (4 - (dimethyl amino)benzylidene) - 5 - (isopropylthio) - 1,3,4 - thiadiazole - 2 - amine[IV] were used in this study to test their antihyperlipidaemic ability and their effect on CK and HMGR activities. The results revealed that compounds(III and IV)showed an activation effect in all concentrations on CK and HMGR activities, while compounds(I and II) showed an inhibitory effect in some concentrations for CK and in all concentrations for HMGR. Therefore, compounds (III and IV) were excluded from this study. The results showed that (10 - 4M) for compound I and (10 - 5M) for compounds II give the best inhibition percentage among the other concentrations on CK and HMGR activities which the kinetic study throughout with these concentrations for these compounds. Simvastatin, which considered as standard drug for lipid lowering, was used for comparsion with the potency of compounds I and II on HMGR activity in treatment of hyperlipidaemia. The results showed an inhibitory effect of simvastatin on HMGR activity with percentage inhibition 88%. The effect of compounds (I and II) on ALT and AST were examined in (10 - 4 M) for compound I and (10 - 5M) for compound II in vitro study. The results showed the inhibitory effect of compounds I in concentration (10 - 4 M) and compound II in concentration (10 - 5M) on ALT and AST activities.The Vmax, Km and type of inhibition for compounds I and II on CK and HMGR activities were studied by using Lineweaver - Burk plot. The results showed that also compound I at 10 - 4M was considered to be a noncompetitive inhibitor for CK activity with Vmax values (1000 and 344.82)U/L for uninhibited and inhibited enzyme respectively and Km value (10) mmol/L. The results also showed that compound II at concentration 10 - 5M was considered to be a competitive inhibitor for CK activity with Vmax value (588.23)U/L and Km values (5.51 and 4)mmol/L for the uninhibited and inhibited enzyme respectively.In vitro, the effect of compound (I) with concentration (10 - 4M) and compound (II) with concentration (10 - 5M) were examined in vivo study. The study was carried out with sixty male Wister mice aged seven to eight weeks and theirweight were (180 - 200 g) ,obtained from animal house , in College of Medicine, Baghdad University. The mice were grouped as follow : group one (12 mice) as control group, group(2) : consists of 48 mice in which the mice were daily administered cholesterol (25mg/k/day), in coconut oil 6% and creamy cheese for 28 days. Lipid profile were measured for twelve mice chosen randomly from G2 to diagnosis hyperlipidemia. Then group2 is subdivided into three groups as follows : group (2.A) : (12 mice) as positive control group in which the mice were daily administered simvastatin (40mg /day) as standard drug for hyperlipidemia, group 2B : (12 mice) in which the mice were daily treated with (10 - 4)M of compound (I)via drinking water for 20 days and Group(2.C) : (12 mice) in which the mice were daily treated with (10 - 5)M of compound II for 20 days. The results showed significant elevation in levels of Tch, TG, LDL - c and VLDL - c, while there is significant reduction in HDL - c levels in G2 comparing to control group(G1), after administration of fat rich diet. Simvastatin, compound I with concentration (10 - 4M) and compound II with concentration (10 - 5M) were administrated to G2A, G2B and G2C respectively. Also, the results showed that the activities of CK reduced for group G2B and G2C while it is increased for G2A. The results also showed that the activities of HMGR were reduced in the three treated groups. The results revealed that compounds I and II exhibit more potent antihyperlipidaemic effect than simvastatin. Also, compound I showed more potent antihyperlipidaemic effect than compound II.The results revealed that compounds I and II showed a noncompetitive inhibitor effect on CK with Vmax values(1000and 166.6) U/L for uninhibited and inhibited enzyme respectively and Km value (0.6) mmol/L for compound I, and with Vmax vales (1000 and 250)U/L for uninhibited and inhibited enzyme respectively and Km value (0.84) mmol/L for compound II.In conclusion, the novel synthetic compounds (I and II) seem to be of interest in the development of new antihyperlipidaemic agents that exhibit inhibition effect on CK while statins cause increase in this enzyme. Also these compounds exhibit inhibition effect on HMGR activity more than simvastatin, which is a key enzyme in cholesterol synthesis.

تحضير مركبات عضوية جديدة ذات صفات بلورية سائلة == Preparing of New Organic Compounds With Liquid Crystalline Properties

اسم المؤلف: محمود عبد الستار يحيى القزاز
اسم المشرف: ابتسام خليفة جاسم
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء الفيزيائية
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: يهدف هذا العمل لدراسة امكانية طلاء سطوح بعض المعادن مثل الفولاذ المقاوم للصدا 316، الحديد الكربوني، النحاس، الالمنيوم والزنك، بالمواد النانوية لتحسين مقاومة التاكل وذلك باستخدام اثنين من التقنيات، الاولى بواسطة الطلاء بالالياف النانوية لمادة متعدد الانيلي | This work aims to study the possibility of coating the surfaces of some metals such as stainless steel 316, carbon steel, copper, aluminum, zinc, with nanomaterials to improve the corrosion resistance using two techniques, first by coating with polyaniline nanofiber using electropolymerization of aniline monomer and the second technique by TiO2 nanoparticles via sol - gel process starting from titanium isopropoxide. The work focused on getting thin and homogeneous layer to cover the entire surface of the metal and protect it from corrosion in artificial seawater solution (3.5% NaCl) at 293, 303, 313, and 323 K.Atomic Force Microscope (AFM), Scanning Electron Microscope (SEM), Energy dispersive x - ray (EDX), x - ray photoelectronic spectroscopy (XPS), and x - ray diffraction (XRD) were used to diagnose and describe the structure and morphology of the layers that cover the surface of the metals under investigation, and finally the corrosion parameters ;corrosion potential (Ecorr), corrosion current (Icorr), protection efficiency (PE%), polarization resistance (Rp) and the effect of temperature on the inhibition efficiency in the absence and presence of polyaniline (PANI) or TiO2 coating at temperature ranging from 293 to 323 K were obtained and expressed as; Ea , ?H*, ?S*, and ?G* of all samples were estimated from Tafel plots using potentiostatic technique.The SEM and AFM images of PANI films reflect nanofibers (diameter from 50 to 70 nm); the thicknesses were measured by special AFM scans. They showed values between )700 to 1564 nm(, which may be attributed to the differences in oxidation - reduction potentials of the metals. The XRD patterns of the deposited PANI showed duplicate broad scattering peaks around 2? of 20? and 25?.The AFM images of TiO2 nanoparticles deposited on specimens revealed that the layer was extremely smooth, the particles are small spherical and the average diameter between 26 and 38 nm.The shifts in Ecorr of the uncoated with comparison of the PANI or TiO2 coated samples were small for; S.S316, C.S, Cu, Al, and Zn which means that the anodic and cathodic reactions affected by the same extent.The Rp of the PANI and TiO2 coated substrate was always more than the uncoated ones that attributed to the weak conductivity of PANI and the semiconducting properties of the Titania. All coated metals with PANI or TiO2 exhibited good degree of corrosion protectiveness. For PANI the PE ranged between 56 and 92 % and the best results was achieved for Zn metal this may attributed to the high corrosion values of the bared Zn, while TiO2 coating showed PE at the range of 68 and 93% and the best was for Al metal. The protection efficiencies showed small changes by increasing the temperature but for TiO2 in some cases the PE somehow increased with increasing the temperature. The data showed that the thermodynamic activation functions (Ea and ?H*) of the corrosion of the coated samples are higher than those of the uncoated ones indicating more energy barrier. The entropy of activation ?S* for the uncoated and coated samples are always negative ,this indicates that the activated complex in the rate determining step represents an association rather than a dissociation step, the measured ?G* values takes positive values and showed almost small change with increasing temperature, indicating that the activated complex was not stable and the probability of its formation decreased somehow with rise in temperature and the ?G* values for coated samples reveal that in the activated corrosion complex becomes less stable as compared to the uncoated specimens.Single cyclic potentiostatic tests conducted at 293 K to follow up the pitting probabilities of each metal in seawater before and after coating. The I - V plots indicated that only SS316 and Aluminium specimens suffer from pitting corrosion and the two types of coating reduces the pitting area of the hysterias loop with pushing the pitting potentials for more positive values

تحضير ,تشخيص, دراسة فعالية مضادة للاكسدة ومضادة للسرطان لمعقدات الذهب (III) مع مركبات حلقية غير متجانسة == Synthesis ,Characterization ,Antioxidant And Anti - Cancer Activity Studies of Gold (III) Complexes With Heterocyclic Compounds

اسم المؤلف: اية جمال عبد الحميد
اسم المشرف: فراس عبد الله حسن
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: دكتوراه
الجامعة: جامعة النهرين - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تضمن موضوع البحث تحضير مركبات حلقيه خماسية وسباعية غير متجانسة متنوعة،من خلال اربعة اجزاء هي : الجزء الاول : - تضمن هذا الجزء تحضير مركبات مشتقات 1, 3, 4 - اوكسادايزول من مركب (ثنائي اثيل مالونيت)، كما موضح بالمخطط (1).الجزء الثاني : - تضمن هذا الجزء تحض | This work involves synthesis of different five, and seven membered heterocyclic rings, and divided into four different parts and the reaction steps for each part are summarized as shown below.First part : This part involved the synthesis of 1,3,4 - Oxadiazoles derived from diethyl malonate.Scheme (1).Second part : This part involved the synthesis of Oxazepine , tetrazoles, and thiazolidinone,from 4,4' - ((((methylenebis(1,3,4 - oxadiazole - 5,2 - diyl))bis(3,1 - phenylene))bis(azanylylidene))bis(methanylylidene))bis(N,N - dimethylaniline).(Scheme 2).Third part : This part involved the synthesis of 1,1' - (1,4 - phenylene)bis(N - substitutedmethanimine) [C1 - 9] from terephthalaldehyde. (Scheme 3). Fourth part : This part involved the synthesis of 1,3,4 - Oxadiazoles derived from terephthalaldehyde and hydrazone carboxamide.In addition, this part deals with the evaluation of antibacterial activities of some of the synthesized compounds. These activities were determined in vitro using disc diffusion method against four pathogenic strains of bacteria (E.coli a, Pseudomonas, Bacillus, and Staphylococcus.), the results revealed that some of these compounds showed measurable activity. (Scheme 4).The liquid crystalline behaviors of the two series have been examined by means of hot - stage polarizing microscopy for the determination of phase transition temperatures and the type of mesophases. The prepared compounds are characterized through determining their melting points, colors physical properties) and (FT - IR, 1H - NMR,) spectroscopy, (C.H.N.S, DSC) analysis and checked by T.L.C.

دراسة البلمرة الكهروكيمياوية وخواص حماية التاكل لطلاء متعدد البايرول على الفولاذ الكاربوني والفولاذ المقاوم للصدا == An Investigation of Electropolymerization And Corrosion Protection Properties of Polypyrrole Coating On Carbon Steel And Stainless Steel

اسم المؤلف: رواء عباس محمد
اسم المشرف: عبد الكريم محمد علي جبر السامرائي
الموضوع العام: علوم الكيمياء
السنة: 2014
الموضوع الدقيق: الكيمياء
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تم تحضير سلسلة من مشتقات 1, 2, 4 - ترايزول بواسطة تفاعلات الغلق ,حضر حامض البنزويك هيدرازايد (1) بواسطة تفاعل مثيل بنزويت مع الهيدرازين ثم تفاعل المركب (1) مع CS2 في محلول كحولي قاعدي ليعطي ملح البوتاسيوم (2). حضر المركب (3) بواسطة غلق ملح البوتاسيوم (2)م | A series of 1,2,4 - triazole derivatives were synthesized by cyclization reaction, the benzoic acid hydrazide (1) was synthesized by reaction of methyl benzoate with hydrazine hydrate then compound (1) was reacted with CS2 in solution of alkali ethanol to give potassium dithiocarbazinate salt (2) , the basic nucleus 4 - amino - 5 - phenyl - 1 - 4H - 1,2,4 - triazole - 3 - thiol (3) was prepared by cyclization of potassium salt (2) with hydrazine hydrate using water as solvent under reflux condition. compound (3) was subjected to addition reaction with different aromatic aldehydes to synthesize Schiff bases (4a,b) which were cyclized by treating with thioglycolic acid to prepare compounds (5a,b).compounds (6) and (7) obtained by cyclization reaction of compound (3) with urea and thiourea. Also in this research, 1,3,4 - thiadiazole derivatives were synthesized by cyclization of thiosemicarbazied with substituted carboxylic acid and sulphuric acid, to yield 2 - amino - 5 - R - 1,3,4 - thiadiazole (8). Schiff bases formation (9a,b) were by reflux of aromatic aldehyde with 2 - amino - 5 - R - 1,3,4 - thiadiazole (8) in the presence of absolute ethanol. Compounds (10a,b) were prepared by cyclization reaction of compounds (9a,b) with thioglycolic acid.The Synthesized compound were confirmed by their melting point ,FTIR ,U.V - visible ,1HNMR spectra and evaluated for their antioxidant activity by using stable free radical 1,1 - diphenyl - 2 - picryl - hydrazyl DPPH. of all tested compounds. compound (5b) was the most active in all concentrations compared to standard Ascorbic acid with an IC50 value 5.84 ?g/ml. In this study, the cytotoxic effects for compounds (5a),(5b),(6),(7),(10a),(10b) were studied in one cultured cellular models (MCF7 cell line) breast cancer (at different concentration) compared to doxorubicin as positive control by cell viability assay (MMT assay), compound (5b) showed the highest cytotoxicity effect with an IC50 value =56.98?g/ml.Also, we examine the cytotoxic effects of gold III complex (AuL2) of bi - dentate ligand (5a) in one cultured cellular models (MCF7 cell line) by High Content Screening and analysis (HCS). The inhibitory effect of AuL2 on breast cancer cell growth was due to induction of apoptosis as evidenced by Annexin V staining and cell shrinkage. We found that AuL2 - mediated lead to disruption of mitochondrial membrane potential (MMP), cell membrane permeability, and release of cytochrome c from the mitochondria into the cytosol. suggesting (AuL2 ) as a potential MCF7 inhibitor. Thus, we suggest that (AuL2) may have therapeutic value in breast cancer treatment worthy of further development. Bis(2 - (4 - Dimethylamino - phenyl) - 3 - (3 - mercapto - 5 - phenyl - [1,2,4]triazol - 4 - yl) - thiazolidin - 4 - one)gold(III) chloride. monohydrate
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