مشاركة
تحضير عدد من مشتقات الادوية الجديدة لحامض الاسكوربيك وسكر الرايبوز وقياس تاثير هذه المركبات على فعالية انزيم اللايبيز والكولين استريز == Preparation A Number of New Drug From The Derivatives From Ascorbic Acid And Ribose And Study The Effect of These Compounds on The Activity of Lipase And Cholinesterase
اسم المؤلف:
محمد يونس حمادي حسين
اسم المشرف:
نزار احمد ناجي | فراس طاهر ماهر
الموضوع العام:
علوم الكيمياء
السنة:
2012
الموضوع الدقيق:
الكيمياء الحياتية
الدرجة:
ماجستير
الجامعة:
جامعة تكريت - كلية التربية - قسم الكيمياء
اللغة:
العربية
مكان الجامعة:
صلاح الدين
الصفحات الاولى:
25T1520 - p.pdf
المستخلص:
In this study, the preparation of a number of new drugs from the derivatives of ascorbic acid (vitamin C) and ribose have been done through the formation of esters of these compounds. The tetra - acid esters of ribose have been obtained with mefenamic acid and methyldopa and aspirin during treatment of mefenamic acid, methyldopa and aspirin chlorides with ribose. The tetra - ester of ascorbic acid with ampicillin has also been obtained through the reaction of ampicillin chloride with ascorbic acid. The Products have been diagnosed by infrared spectroscopy (IR).The effect of four products has been studied on lipase activity compared with metronidazole benzoate as ester on lipase activity. The results showed that the highest activity of the enzyme was when tetra aspirin ester of ribose was used (2.36 Cherry - Crandall’s unit) and the lowest activity (1.37 Cherry - Crandall’s unit) when using tetra ampicillin ascorbic acid ester. Other compounds showed a slight increase in lipase activity.The effect of four compounds have been studied on cholinesterase activity, the results showed that tetra ampicillin ester is the highest effect to increase cholinesterase activity
