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تحضير وتشخيص بعض مركبات قواعد شف الحلقية الجديدة ودراسة انتقائية معقداتها وبوليمراتها الكلابية == Synthesis And Characterization of Some New Heterocyclic Schiff Bases And The Study of Their Metal Ions Selectivity Complexes And Chelating Polymers
Author name:
دينا سعدي احمد مخلف الفلاحي
Supervisor name:
علي طه علي السامرائي
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
Tikrit University - Faculty Of Education - Chemistry Department
Language:
Arabic
University location:
Salahaddin
First pages:
25T1498 - p.pdf
Abstract:
تتضمن هذه الدراسة تحضير مشتقات الاوكسادايازول (4,2,1 و4,3,1) ودراسة الفعالية البايولوجية لبعضها وذلك بتحضير المركب 2 - امينوثايازول حامض الخليك (1) من تفاعل 2 - امينوثايازول مع كلورو حامض الخليك في الايثانول المطلق ثم تحضير معوضات الاميدواوكزيم (6 - 2) ا | This study deals with the synthesis of (1,2,4 & 1,3,4 - ) Oxadiazole compounds and evaluation their biological activity.The synthesis was outlined as follows : - 1 - 2 - aminothiazole acetic acid (1) was prepared through the reaction of 2 - aminothiazole with chloroacetic acid.2 - Some new amidoxime derivatives (2 - 6) were synthesized by the reaction of substituted aromatic nitriyle with hydroxylamine hydrochloride.3 - the reaction of compound(2 - 6) with 2 - aminothiazole acetic acid (1) in the presence of (DCC) afforded compounds (7 - 11) namlly; N - O - (subs) amidoximyl - thiazol - 2 - yl - amino carboxylate. cyclo dehydration reactions of compounds(7 - 11) by heating yielded the corresponding1,2,4 - oxadiazol (12 - 16).4 - 5 - pyridyl - 1,3,4 - oxadiazole - 2 - thiol (17) was prepared by the reaction of Nicotinic acid hydrazide with carbondisulfide (CS2) in alcoholic(KOH).5 - Reaction of compound (17) with aryl halides in the presence of alcoholic(KOH)yielded the corresponding thioethers (18 - 25). 6 - Some hydrazone derivatives (28 - 30) were prepared by the condensation reaction of benzoic acid hydrazide (27) with appropriale aromatic aldehyde , these hydrazone were cyclized to the corresponding1,3,4 - oxadiazoles (31 - 33) using(PbO2) in glacial acetic acid. These compounds were characterized by asins available spectroscopic methods (UV,IR and NMR) , the spectral data obtained are combatable with the structures assigned to these compounds , some of these compounds were tested againstThis study also include the evaluation of biological activity of some prepared (12,13,14,15,16,18,19,20,21,23,24,25,31,32&33) on the growth of four types of pathogenic bacteria , (Escherichia coli, pseudomonas auruginosa, klebsela pneumoniae (gram negative) and staphylococcus aurous (gram positive) ).The results abtained are shown in tables (22 - 24).
