Share
تحضير وتشخيص وتقيم الفعالية البيولوجية لبعض مركبات الفورمازان المشتقة من قواعد شف الجديدة ومعقداتها مع بعض العناصر الانتقالية == Synthesis, characterization and biological evaluation of some new Formazan compounds derived from Schiff Bases and their complexes with some transition Metals.
Author name:
اعراف محمود داود
Supervisor name:
حيدر عباس مهدي
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Thi-Qar - College Of Science - Chemistry Department
Language:
English
University location:
Dhi Qar
First pages:
25T1537 - p.pdf
Abstract:
This thesis contains three chapters represents, the first chapter introduction and interested in studying the chemistry of schiff base and derivatives of formazan, their complexes in terms of their characteristics, importance and synthesis.The second chapter is interested in describing the chemicals and procedures used in the synthesis of the required compounds, and the study of physical measurements, synthesis methods of compounds and evaluation as well as the biological activity.In this research, four new derivatives of formazan (L3, L4, L5 - 4d), which synthesized from the reaction of Diazonium salt amine with suitable Schiff base (L1, L2 - 2d). The Schiff base can product of different primary amines with several aromatic aldehyde and synthesized both of the (Schiff bases, formazans) suitable complexes.The third chapter Results and Discussion, identified synthesized formazan derivatives as well as Schiff bases prefix and its complexes by appropriate spectral methods including of infrared spectroscopy (FT - IR) for all compounds, Nuclear Magnetic Resonance spectrum (1H - NMR) for all compounds Microanalysis (CHNS) for the majority of compounds as well as Mass spectra. For all complexes were recording certain physical properties, such as melting point (m.p.). Monitoring progress of the chemical reaction by using thin chromatography layer (TLC). We synthesis eight complexes (three from Schiff bases and five from formazan derivatives) were complexes with ions (Co, Ni, Cd), then measuring the molar conductivity of complexes. Then study the biological effectiveness for some compounds have been chosen complexes Schiff bases, as well as formazan complexes to determine the effect of active groups in these compounds to evaluate the efficiency ofXIthe compounds against different type of bacteria.The research also includes a test of biological effectiveness of the prepared ligands and their metallic complexes, where we study response inhibitory to the three types of bacteria, a gram positive type of bacteria (Staphylococcus aureuse) and gram negative type of the bacteria (Escherichia Coli and salmonella species) and compared with the standard inhibitor (Cipro).The biological effectiveness swohs positive results as it was noted The ligand L1, L2, L3, L4, L5 and Schiff base 4d Showed lower efficiency than the standard inhibitor trend three types of bacteria. The prepared complexes from ligands appeared high effective than the effectiveness of the ligands itself The formazan (L3, L4, L5 dna 2d) appeared high effective than the effectiveness of the prepared Schiff base
