تحضير وتشخيص ودراسة بايولوجية لمشتقات جديدة من - 3,4,0 اوكسادايزول و3,4,0 - ثايادايازول ومعقداتها مع بعض العناصر الانتقالية واستخدامها في استخلاص الكوبلت الثنائي == Synthesis, Characterization, and Biological activity Study of New 1,3,4 - Oxadiazole and 1,3,4 - Thiadiazole Derivatives and Some of Their Transition Metal Complexes and Using in extraction of cobalt ion (ll)
Author name:
ازهار حميد كاطع
Supervisor name:
ساهر عبد الرضا علي | ابراهيم عبود فليفل
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Thi-Qar - College Of Science - Chemistry Department
Language:
Arabic
University location:
Dhi Qar
First pages:
25T1533 - p.pdf
Abstract:
The thesis include preparation and characterization of some new derivations of 1,3,4 - oxadiazole and 1,3,4 - thiadiazole as ligands which are : - L1 = 2,2' - [(1E,2E) - ethane - 1,2 - diylidenedi(2E)hydrazin - 1 - yl - 2 - ylidene]bis(5 - methyl - 1,3,4 - oxadiazole) L2 = 2 - hydrazinyl - 5 - [(2E) - 2 - {(2Z) - 2 - [2 - (5 - hydrazinyl - 1,3,4 - thiadiazol - 2 - yl)hydrazinylidene]ethylidene}hydrazinyl] - 1,3,4 - thiadiazole L3 = 2,2' - {1,3,4 - thiadiazole - 2,5 - diylbis[(1E)hydrazin - 2 - yl - 1 - ylidene(E)methylylidene]}bis(6 - methoxyphenol) with structural formula L1 L2 L3 The new complexes were prepared from the reactions of ligands L1,L2,L3 with the transition metal salts (CrCl3.6H2O, COCl2.6H2O,NiCl2.6H2O) . The elemental analysis (CHN) , Infrared(IR) Spectroscopy , Nuclear Magnetic Resonance Spectroscopy (1H - NMR) , Mass Spectra , Magnetic Susceptibility and Molar conductivity techniques were used to characterize the structural formula of these ligands and their complexes.1) The complexes of [Cr(III) , Co(III)] for all ligands have shown octahedral configuration. 2) Complexes of [Ni(II)] with all ligands have shown square planar configuration.liquid - liquid extraction using L2 as extracting agent , The best results were obtained from liquid - liquid extraction in which Co(ll) had a 95% extraction rate at pH 9 ,temperature degree at 40 C0 Testing the biological activity for ligands and their complex by using spreed method and measurement inhibition zone by using (DMSO) as solvent and erythromycin as standard bactericidal , using in this study two types from bacteria one gram negative bacterial strains (Escherichia coli ) and other isgram positive bacteria strains staphylococcus aureus
