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تخليق وتشخيص ودراسة الخصائص التفلورية والمضادة لفايروس نقص المناعة المكتسبة لبعض مشتقات البركنينولون الجديدة == Synthesis, Characterization, Fluorescence Properties, Anti - Hiv Activity And Molecular Modeling Study of Some New Pregenolone Derivatives
Author name:
رواء علاوي كاظم القريشي
Supervisor name:
نجم عبود لعيبي المسعودي | نبيل عبد عبد الرضا
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Doctorate
University:
University of Al-Qadisiyah - College Of Science - Chemistry Department
Language:
Arabic
Full text from the source:
https://qu.edu.iq/repository/wp-content/uploads/2017/04/%D8%A7%D9%84%D8%AC%D8%B2%D8%A1-%D8%A7%D9%84%D8%A7%D9%88%D9%84-%D9%85%D9%86-%D8%A7%D9%84%D8%B1%D8%B3%D8%A7%D9%84%D8%A9.pdf
University location:
Qadisiyah
First pages:
25T1476 - p.pdf
Abstract:
نظرا لما تتمتع به مركبات الازو من تطبيقات مهمة في كل من المجالين الاكاديمي والتطبيقي فقد تمحورت دراستنا على تحضير ستة ليكاندات ازو جديدة مشتقة من المركب 5,4 - ثنائي فنيل اميدازول ودراسة السلوك التناسقي لكل منها مع ستة ايونات فلزية هي Co(II) , Ni(II) , C | Azo compounds have important applications in both of academic and applied fields, Accordingly, our study based on the synthesis of azo compounds derived from 4,5 - diphenyl imidazole and characterization of these azo compounds with their metal complexese containing Co(II) , Ni(II) , Cu(II) , Zn(II), Cd(II) and Hg(II) ions. Mass Spectra of ligands and their complexes were supported their molecular formula, while H1NMR spectra of ligands agreed well with the suggested structures , The C.H.N. and Atomic absorption analysis showed a good agreement with the calculated values , The purity of ligands and their complexes were examined by TLC and the values of Rf were values measured.Electronic spectra of complexes showed a bathochromic shift comparing to ligands spectra as a result of the coordination between the metal ions and ligands. The concentrations that obeyed Beer - Lambert Law of the complexes were determined from calibration curves , Mole Ratio Method indicate a ratio (1 : 2) (Metal : ligand) for the complexes of (DPEPI) and (DPDED) while other complexes with other ligands show a ratio (1 : 1) (Metal : ligand).Satiability Constants of the complexes were calculated and found that the Stability constants of complexes of the first ligand (DPEPI) were ( 2.955×10 12) >(2.294× 1011 ) <(1.121×10 12 ) < (1.108 ×1011 ) varied in the arrangement as Co(II)< Ni(II) < Cu(II)> Zn(II) which agree with Irving - Williams Series. This arrangement was applied on the complexes of the other ligands. The Conductivity measurements of complexes showed non ionic character. Apparently the magnetic susceptibility values agree with their values of the octahedral high spin complexes for Co(II)) while the complexes of Zn(II), Cd(II), and Hg(II) were diamagnetic. IR Spectra of complexes showed obvious changes of the frequencies of ? (N=N) of azo group and ?(C=N) of heterocyclic imidazole ring as result of coordination with metal ions, While the frequencies of ?(C=N) of azomethine group did not show any significant change for complexes comparing to the ligands spectra ,New bands were appeared in the region (400 - 500) cm - 1 in the spectra of complexes that due to frequencies of ?(M - N) because of coordination process. From the previous results the purposed structures of the complexes can be summarized as shown in the following : Proposal structure of (DPEPI) Complexes Proposal structure of (DIDHP), (DIDMP),
