تحضير وتشخيص مشتقات جديدة للكومارين - 3 - كاربوكسلك اسيد == Synthesis And Characterization of New Derived From Coumarin - 3 - Carboxylicacid
Author name:
كوثر عبد الواحد عبد الحميد
Supervisor name:
شذى فاضل نارين الزبيدي
General topic:
Chemistry
Specific topic:
Organic Chemistry
Degree:
Master
University:
University of Baghdad - College Of Science For Girls
Language:
Arabic
University location:
Baghdad
First pages:
25T1529 - p.pdf
Abstract:
تعد مشتقات الكومارين مهمه من الناحية البايلوجية والصناعيه والدوائيه وعلى هذا الاساس استمرت الدراسات في تحضيرمشتقات جديده للكومارين وعليه فقد تم في هذا البحث تحضير عدد من مشتقات للكومارين وعددها 23)) بالاضاقة الى المركب 2 - oxo - 2H - coumarin - 3 - carbox | The coumarin and his derivatives class of heterocyclic compoundsThey are presente in a large family of products with broad biological and industrial activities.This fact leads as to synthesis twenty eight compounds of heterocyclic by several methods show in diagrams (1, 2).Than we characterized this compounds by some spectral analysis Such as : (FT - IR), (GCMS), (H - NMR) and determination of their physical properties such as melting points and color.This work involved : 1. Synthesis of base compound ( coumarin 3 - carboxylic ) by reaction Malonic acid with Salicylaldehyde in Petroleum ether as a solvent.2. Synthesis of k1 by reaction ( coumarin 3 - carboxylic ) with Thionyl chloride in Dichloro methane as a solvent.3. Synthesis of k2 by reaction k1 with hydrazine hydrate 99%. 4. Reaction k2 with six kinds of aromatic aldehyde to Synthesis of Schiff Bases : K8 - k7 - k6 - k5 - k4 - k35. Synthesis of five from Tetrazoles compounds by reaction Schiff Bases With sodium azide in dioxane as a solvent. 6. Synthesis of five from thiazolidinone compounds by reaction Schiff Bases with Mercapto acetic acid in THF) as a solvent. 7. Synthesis of five from azetidinone compounds by reaction Schiff Bases with ChloroacetylChloride in Dioxane as a solvent. 8. Synthesis of five of thiourea compounds by reaction Schiff Bases with thiourea in methanol as a solvent.
