تحضير وتشخيص بعض مشتقات الملئيمات الجديدة الحاوية على حلقات 2 - بايرازولين وبايرمدين - 2 - اون / ثايون ودراسة فعاليتها البايولوجية ثم بلمرتها ذايا او مع بعض معوضات الفاينيل == Preparation And Identification Some New Maleimide Derivatives Containing 2 - Pyrazoline And Pyrimidin - 2 - One/Thione Rings And Study of Biological Activity Then Homopolymerization Or With Some Substituted Vinyl
Author name:
غزوان حسن عبد الوهاب الصميدعي
Supervisor name:
احمد شهاب حمد الجنابي | خالد مطني محمد الجنابي
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
Tikrit University - College Of Science - Chemistry Department
Language:
Arabic
University location:
Salahaddin
First pages:
25T1504 - p.pdf
Abstract:
ترتبط بعض الامراض النفسية مثل مرض الاكتئاب الشديد والفصام بتغيرات مناعية حتى ولو كان الشخص سليم من الناحية الجسمية. على الرغم من ان هذين المرضين لايعتبران حاليا من الامراض المناعية الاساسية لكن توجد ادلة تقترح كون الالتهاب يلعب دورا في عملية الاصابة بالاك | Psychiatric illnesses, particularly major depressive disorder (MDD) and schizophrenia, are associated with inflammatory processes even in individuals who are otherwise physically healthy. While it is unlikely that MDD and schizophrenia are a primary inflammatory disorder, evidence suggesting that inflammation plays a subtle role in the pathophysiology of MDD and schizophrenia has been obtained. Several studies have shown that proinflammatory markers have increased in these disorders. However, these studies have included patients with obvious inflammation, i.e., patients with C - reactive protein >6 mg/L. A comprehensive study concluding that these conditions are inflammatory disorders and inflammation is due only to these two disorders have not been performed. In the present study, the inflammatory natures of MDD and schizophrenia were investigated. To achieve this goal, serum levels of the interleukins - 6 (IL - 6) and interleukins - 18 (IL - 18), tumor necrosis factor alpha (TNF?), and soluble interleukin - 2 receptor (sIL - 2R) in MDD and schizophrenia were obtained and compared with those of the control group. The total serum and ionized levels of calcium (Ca) and magnesium (Mg) in the studied groups were then measured.Significant increases (p < 0.05) in the serum levels of IL - 6, IL - 18, TNF?, and sIL - 2R in the MDD and schizophrenic groups were observed in comparison with those of the control group. In general, the schizophrenic group showed higher levels of inflammatory markers than the MDD and control groups. These results indicate a clear inflammatory state in both disorders. The schizophrenic patients exhibited significant changes in the ratios of T. Ca/Mg and I. Ca/Mg in comparison with those of the healthy and MDD patients; this finding reveals that T. Ca/Mg and I. Ca/Mg ratios are better indicators of cation state than serum cation levels alone.Basing on the results of the present study, we concluded that the immunological responses of the MDD and schizophrenia are significantly stimulated. These conditions may be considered inflammatory disorders because of increased pro - and inflammatory factors in both disorders.Anti - inflammatory drugs may be potentially used as an adjuvant aid in treating schizophrenia and MDD. Future studies may involve investigating other proinflammatory markers and following up results of treated patients that utilized and did not utilize anti - inflammatory drugs.
