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تخليق قواعد شف جديدة مشتقة من انهدريد البايرومليتك == Synthesis ,Antibacterial of Some Novel Schiff Bases Derived From Pyromellitic Dianhydride
Author name:
عذراء محمد سلوم
Supervisor name:
امينة عبد الرحمن فياض | عماد تقي علي
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University of Baghdad
Language:
English
University location:
Baghdad
First pages:
25T1508 - p.pdf
Abstract:
تم تخليق قواعد جديده مشتقة من انهدريد ثنائي البايرومليتك بعدة خطوات. حيث حضرت مشتقات حامض البايرومليتك المتناظره ac[ I ] من تفاعل انهدريد ثنائي البايرومليتك مع بعض الامينا ت الاورماتية الحاويه على (مجاميع ساحبه واخرى دافعة ) في الاسيتون كمذيب. واشتملت | The novel Schiff bases derived from pyromellitic dianhydride were synthesized by several steps reaction. A symmetrical diamic acide [I ]a - c was synthesized by the reaction of pyromellitic dianhydride with some aromatic amines (containing electron withdrawing , repulling groups ) in dry acetone.In the second step the diacids were converted to their corresponding diimide [II ]a - c using acetic anhydride and sodium acetate system as a dehydrating agent, via the intramolecular cyclization steps of amic acids.The third step was to synthesis the hydrazone derivatives from the reaction of diimides , with 80 % hydrazine hydrate at (50 - 60)C?.These hydrazone derivatives were allowed to react with several aromatic aldehydes to form new Schiff bases via step four at a temperature near by (80 - 85)C?. As shown in the following scheme (3.1). All the novel compounds and their structures have been ascertained by their melting points , mixed melting points , C.H. N analysis , FTIR , UV - Viss. and 1HNMR spectroscopy for some of them. Also the biological activity of some of them was studied which showed that these compounds have different activities towards the studied bacteria.
