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معرفة , اتجاه وسلوك النساء الحوامل عن فقر الدم خلال الحمل في مستشفي بغداد التعليمي 2016 == Knowledge, Attitudes and Practice of Pregnant Women about Anemia during Pregnancy in Baghdad Teaching Hospital - 2016

اسم المؤلف: رؤى صفاء سعيد
اسم المشرف: علياء مكي حسن الصافي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب العائلة
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Back ground : Anemia constitutes a public health problem worldwide, in both developed and developing countries.Aims : 1) assess the level of knowledge, attitude and practice of pregnant women about anemia 2) assess the association between knowledge of pregnant women and their socio - demographic variances 3) assess the association between the practice of pregnant women and their socio - demographic variances. Methods : The study was cross - sectional, carried out in among pregnant Baghdad Teaching Hospital, from 25th February to 28th April, 2016. A total of 300 pregnant women participated in the study. The tool of study was questionnaire. Chi - square test was used to test the statistical significance (p - value< 0.05).Results : The study revealed 63.3% of pregnant women had good knowledge, positive attitude found in 65.3% and health practice in 59.3% among pregnant women regarding anemia, the study show association between the knowledge of the pregnant woman and educational level of her and her husband, also there is association between the practice of pregnant woman and her occupation.Conclusion : A noticeable general good level of knowledge , attitude and practice among pregnant women regarding anemia during pregnancy ,level of knowledge in pregnant woman associated with the educational level of her and her husband and healthy practice increase in employed pregnant woman.Recommendations : Raise the level of knowledge and practice for prevention, learn pregnant women healthy dietary habit and encourage pregnant women to early registration in primary health care center.

انتشار ومتنبات الاكتئاب لدى عينة من المرضى المصابين بداء الذاب الحمامي المجموعي == Prevalence and Predictors of Depression in a Sample of patients with Systemic Lupus Erythematosus

اسم المؤلف: زهراء عدنان
اسم المشرف: فائق ايشو كوريال | مشتاق طالب هاشم
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: المرضى والطرائق : شملت الدراسة المقطعية (60) مريضا مصابا بداء الذاب الحمامي المجموعي تم تشخيصهم حسب المعاييرالمطورة التشخيصية بواسطة الكلية الامريكية لامراض الرثية.تم جمع بيانات المرضى الديموغرافية والسريرية بما في ذلك العمر والجنس ومعيار كتلة الجسم وحالة التدخين والحالة الزوجية والحالة الوضيفية واعراض سابقة لشمول الجهاز العصبي المركزي ومدة المرض وفاعلية المرض بواسطة مقياس فاعلية المرض لداء الذاب الحمامي ,الادوية المستخدمة وتحاليل الدم وشاكلة الاضداد. تم تحري جميع المرضى بواسطة المعايير التشخيصية لنوبة الاكتئاب الرئيسية د س م 5 . النتائج : نسبة انتشار الاكتئاب كانت (31.7%),نسبة الاكتاب الحاد لوحظت في (13.3%) من الحالات بينما كانت نسبة الاكتئاب المتوسط الشدة (8.3%).علاوة على ذالك الحالات الفعالة حسب مقياس فاعلية المرض لداء الذاب الحمامي12< مثلت اعلى نسب الاكتئاب(40%).مقارنتا ب(20%) لحالات المرض الخفيفة الى متوسطة الشدة.لا توجد هناك اهمية اواحصائية معتد بها للفرق في معدل فاعلية المرض لداء الذاب الحمامي بين الفئات شديدة الاكتئاب) .(p>0.05المستوى التعليمي كانت له علاقة عكسية مع الاكتئاب معتد بها احصائيا,مرضى داء الذاب الحمامي من غير تعليم رسمي كانت لهم اعلى نسب الاكتئاب (85.7%)مقارنتا لمعدل مابين (21.7%و29.4%)لمن مستوى تعليمهم اعلى.خطورة الاصابة بالاكتئاب لم تكن مختلفة في حالة وجود اوغياب اعراض تخص شمولية الجهاز العصبي المركزي بالمرض(33.3%و3.35)على التوالي.العمر والجنس والحالة الزوجية والحالة الوظيفية لايوجد لهراابط ملحوظ او معتد احصائيا مع الاكتئاب.الادوية التي سبق للمريض تعاطيها والتي تشمل اي من البريدنيزولون ,هايدروكسي كلوروكوين,سايكلوفوسفامايد ,ازاثيوبرين ,مايكوفينوليت موفتيل ,ميثوتريكسيت ,كلوروكوين ,لا توجد لها اهمية او رابط احصائي معتد مع الاكتئاب.لا توجد اهمية ملحوضة او معتدة احصائيا لتاثير وجود نتيجة ايجابية لاضداد النوى ,اضداد دي ان اي ذو الطاقين وعوز المتممة (ج3و /او ج 4)على نسبة الاصابة بالاكتاب. الاستنتاجات : نسبة الاكتئاب لدى المرضى المصابين بداء الذاب الحمامي المجموعي شائعة نسبيا.وتزداد مع زيادة فعالية المرض. المستوى التعليمي كانت له علاقة عكسية مع الاكتئاب معتد بها احصائيا. | Background : Systemic lupus erythematosus (SLE) is a multi - systemic auto immune inflammatory disease in which genetic and environmental factors implicated in its pathogenesis. Depression is a potentially life - threatening disorder that affects hundreds of millions of people all over the world. The World Health Organization has ranked depression the 4th leading cause of disability worldwide.Objectives : The aim of this study was to evaluate the prevalence and predictors of depression in a sample of Iraqi patients with SLE if present. Patients and methods : This cross - sectional study involved 60 patients with SLE diagnosed according to revised American College of Rheumatology (ACR) classification criteria. Demographics and clinical data were collected including age, sex, BMI, smoking status, marital status, unemployment, educational status, crowding index, history of CNS involvement and disease duration. Disease activity for SLE was assessed with the SLE Disease Activity Index (SLEDAI). Medications used, blood investigations and autoantibody profile were collected, all subjects were screened for depression by using the Diagnostic and statistical manual of mental disorders - 5 ( DSM5) diagnostic criteria of depression.Results : The prevalence of depression was (31.7%). A severe form of depression was observed in 13.3% of SLE cases, while a mild degree of depression was elicited in 8.3% of the cases. Furthermore, cases with a severe form of disease evaluated by SLEDAI score >12 had an obviously higher rate of depression (40%) compared to 20% among those with mild or moderate disease. There was no important or statistically significant difference in median SLEDAI score between depression severity categories (p more than 0.05). Educational level had a statistically significant negative association with depression, SLE cases with no formal education had the highest rate of depression (85.7%) compared to a rate between 21.7% and 29.4% for higher level of educational attainment. The risk of having depression was not different in the presence or absence of central nervous system (CNS) involvement (33.3% and 31.3% respectively), age, gender, marital status and employment status had no obvious or statistically significant association with depression. The history of using each of prednisolone, hydroxychloroquine, cyclophosphamide, azathioprine, mycophenylate, methotrexate and chloroquine had no important or statistically significant association with depression. Also the presence of antinuclear antibodies and anti - double stranded Deoxyribo nucleic acid (DNA) antibodies and the decrease in complement (C3 and/or C4) had no important or statistically significant effect on the presence of depression.Conclusions : The prevalence of depression in SLE patients was relatively high. SLE disease severity increase depression rate. Educational level had statistically negative association with depression

التحليل الجزيئي للجين CYP21A2 في المرضى العراقيين المصابين بتضخم الغدة الكظرية الولادي == Molecular Analysis of CYP21A2 Gene in Iraqi Patients with Congenital Adrenal Hyperplasia

اسم المؤلف: رقية غياث ياسين العبيدي
اسم المشرف: بسام موسى صادق الموسوي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - الوراثة
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Congenital adrenal hyperplasia (CAH) is a group of autosomal - recessive disorders that result from a genetic defect in the pathway of steroidogenesis. The most common type is 21 - hydroxylase enzyme deficiency (21 - OHD), which accounts for 90 - 95% of cases and is categorized into two clinical forms : severe classic early onset (salt wasting and simple virilizing) and milder non - classic late onset forms. The molecular analysis of mutations affecting CYP21A2 gene coding for 21 - OH enzyme was not tried earlier in Iraqi patients.Aim of Study : To analyze the commonly expected mutations affecting CYP21A2 gene causing 21 - hydroxylase and thus congenital adrenal hyperplasia in Iraqi children and to determine the frequency of each type and their clinical impact.Patients, Materials & Methods : Fifty - four children with a clinical diagnosis of CAH were recruited from the Pediatric Endocrine Consultation Clinic / Children Welfare Hospital - Baghdad and the Genetic Consultation Clinic - Teaching Laboratories / Medical City - Baghdad during the period between September 14th, 2014 and March 14th, 2015. The clinical diagnosis of 21 - hydroxylase deficiency was made when the patients presented with ambiguous genitalia in females with or without dehydration, or vomiting and dehydration with normal male phenotype early in life, or pseudo - precocious puberty later in life.Peripheral blood samples were collected from all patients. Two samples were taken from those with ambiguous genitalia; one for chromosomal analysis and sex determination and the other for DNA analysis. For the other cases, a single sample was taken for DNA analysis.The other tests, namely electrolytes and hormonal assessment were sent for to be performed by another laboratory (governmental or private).Two cases with ambiguous genitalia showing male karyotypes were excluded from this study as they do not fit in the criteria of 21OHD.Molecular analysis of CYP21A2 gene was performed by PCR amplification using biotinylated primers and hybridization of amplification products to a test strip containing allele - specific oligonucleotide probes immobilized as an array of parallel lines. The bound biotinylated sequences are detected using streptavidin - alkaline phosphatase and color substrates according to the manufacturers’ instructions.Results : CYP21A2 gene was analyzed by CAH StripAssay® for detection of 11 common point mutations, and 50% of deletions and conversions in all 52 cases. Mutations (point mutations and deletions/conversions) were detected in 36 (69.2%) cases while 16 (30.8%) cases had undetected mutations. The most frequent mutations were : large deletions / conversions in 11 (21.15%), Q318X in 7 (13.46%), I2 Splice in 6 (11.54%), I172N in 5 (9.6%), Del 8bp in 1 (1.9%), V281L in 2 (3.85%), P453S in 1 (1.9%), R483P in 1 (1.9%) and multiple mutations in 2 cases (3.85%). Among those with large deletions/conversions, deletion/conversion (P30L, I2Splice, Del8bp) found in 3 (5.8%) cases, Deletion/conversion (P30L, I2 Splice, Del8bp, I172N) in 2 (3.85%) cases, Deletion/conversion (Cluster E6, V281L, L307 frameshift, Q318X, R356W) in 4 (7.7%) cases, complete gene deletion in 2 (3.85%) cases.Four mutations (namely P30L, R356W, Cluster E6, L307 frameshift) were not detected in any of our cases.Most cases demonstrated good correlations between genotypes and phenotypes. In the salt wasting group, the correlation was found in all cases with homozygous genotype, while among the simple virilizing group, the concordance of genotype/phenotype was found in all cases of group B (5 cases with homozygous I172N) and the single case in group A (homozygous I2 Splice), while it was absent in group null (one case withhomozygous deletion/conversion) and in group C (one case with homozygous V281L).Conclusions : 1. The majority of 21 - hydroxylase deficiency cases were females presented early in life with ambiguous genitalia with/without salt losing crisis, while a smaller number of patients were males with normal genitalia and salt wasting with/without precocious puberty; the patients have a high rate of parental consanguinity.2. There is a diversity of mutations affecting CYP21A2 gene in Iraqi 21 - hydroxylase deficiency patients, with a good percentage of undetected mutations.3. The diagnosis of 21 - OHD in CAH patients will be made more accurate when based on results of molecular testing.4. The data of molecular studies are useful in genetic counseling, in prenatal diagnosis and offering accurate treatment plan during pregnancy and in detection of carriers in families having previously affected child, diminishing the complications for these families

تاثير قطر دوالي الخصيه على نوعية السائل المنوي للمرضى المصابين بدوالي الخصية غير السريري == The Impact of the diameter of spermatic veins on Seminal fluid Analysis of patients with Subclinical Varicocele

اسم المؤلف: ابراهيم جاسم حمادي
اسم المشرف: غسان ثابت سعيد | رعد حفظي توفيق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: ان الصحة الانجابية هي انعكاس للحالة الصحية العامة والتي تشمل الصحة العقلية والفيزيائية والاجتماعية وليس مجرد مجموعه الامراض المتعلقة بالجهاز التناسلي ووظائفه وعليه يعد العقم مرضا يستحق التشخيص والعلاج . يعرف العقم على انه عدم القدرة على الانجاب بعد سنة من الزواج بدون وجود اي مانع للعلاقة بين الزوجين . يشمل العامل الذكري حوالي 25 - 30 % من كل حالات العقم وايضا 30% اخرى بالاشتراك مع العامل الانثوي . ان 60% من عقم الرجال ناتج عن عوامل جينية اما الاسباب الاخرى فقد تكون نتيجة لدوالي الخصيتين ، عوامل بيئية ، عقاقير طبية ، تعاطي الكحول او التعرض المستمر للحرارة العالية او المواد الكيميائية....الخ. يعد مرض دوالي الخصيتين من الامراض الشائعة بين الرجال الذين يعانون من العقم وهو عبارة عن توسع وتعرج الاورده الناقلة للدم الراجع من الخصيتين نتيجة لتلف الصمامات الوريدية وينعكس ذلك سلبا على الوظيفة الطبيعية للخصية نتيجة لارتفاع درجه حرارة الخصية بسبب تراكم الفضلات الكيميائية من الغدد فوق الكلوية وكذلك الكليتين اضافة الى اسباب اخرى. يشكل دوالي الخصية السريري حوالي 15% بين الرجال ويشخص سريريا بفحص الخصيتين . اما في حالات اخرى لايمكن تشخيص دوالي الخصيه عن طريق الفحص السريري فقط وعليه تستخدم وسائل اخرى للتشخيص حيث يتم استخدام اجهزه الفحص بالموجات فوق الصوتية (السونار) لغرض تشخيص حالات كهذه ويسمى الدوالي غير السريريه وهو موضوع البحث . اجريت الدراسة على 122مريضا في عيادة علاج العقم في مستشفى اليرموك التعليمي بغداد/العراق. وقد استثني من الدراسة اي مريض مصاب باي مرض ممكن ان يتعارض مع الخصوبة وقد اخذت معلومات عامة من المرضى كذلك تم قياس الطول والوزن وقد اجريت لهم بعض التحاليل المختبرية كتحليل السائل المنوي وقياس مستوى بعض الهرمونات في الدم والتي شملت الهرمون المحفز للحويصلات((FSH,هرمون الجسم الاصفر (LH) وهرمون الشحمون الذكري(Testosterone) .كذلك تم فحص السائل المنوي للتاكد من وجود جينFasL)) لمجموعه تتكون من 60 مريضا والذين يعانون من الدوالي غير السريريه في مختبرات جامعة مانشستر مترو بوليتان في المملكة المتحدة. قسم المرضى الى مجموعتين الاولى تشمل المرضى المصابين بالدوالي السرير ي والمجموعة الثانية وتشمل المرضى المصابين بالدوالي غير السريري وقد تم مقارنه النتائج مع 50 مريضا سليما وقادرا على الانجاب . لقد اجريت عمليات جراحيه لعلاج الدوالي غير السريريه ل 60 مريضا وملاحظه التغيرات التي قد تطرا على متغيرات السائل المنوي والهرمونات وكذلك حجم الخصية . اوضحت الدراسة تاثيرا سلبيا بين المرضى الذين يعانون من الدوالي السريريه ومتغيرات السائل المنوي حيث كان التاثير واضحا في قله اعداد الحيوانات المنوية وكذلك سرعتها وشكلها الطبيعي كما اثر سلبا على حجم الخصيه المصابة وكذلك اظهر الفحص زيادة معنويه في هرمون (FSH) ونقص واضح في الهرمون الذكري (T).دون التاثير على هرمون LH)). اظهرت الدراسة تاثير دوالي الخصية غير السريري على متغيرات ا لسائل المنوي حيث كان التاثير على عدد الحيوانات المنوية وكذلك على سرعه الحيوانات المنوية وعلى شكلها الطبيعي دون التاثير على حجم الخصية او على هرمونات FSH),) او LH)).مع تاثير معنوي واضح على هرمون التستوستيرون(T) وكانت نتائج فحص ال FasL))مرتفعه لدى مرضى المجموعه. يستنتج من هذه الدراسة ان دوالي الخصية غير السريريه له تاثير واضح على بعض متغيرات السائل المنوي والهرمون الذكري وان اجراء العملية الجراحية لبعض المرضى يساعد في تحسن مستوى الخصوبة لديهم | Reproductive health is a state of complete physical, mental and social well - being and not merely the absence of disease or infirmity in all matters relating to the reproductive system and to its functions and processes. Infertility should, therefore considered to be a disease process worthy of investigation and treatment. Infertility defined as the inability of a couple to conceive after 1 year of unprotected intercourse. Male factors alone constitute about 25% - 30% of all cases of infertility, and they contribute to another 30% in combination with female factors and about 60% of male factor infertility may be due to genetic causes, others could be due to varicocele, genitourinary infections, environmental agents drugs, alcohol, life style factors like age and obesity. Varicocele is a state of dilated, elongated and tortuous veins of the pampiniform plexus of the spermatic cord typically developed during adolescent and have been found in about 15٪ of the general populations This condition is pathophysiologically characterized by retrograde flow in testicular veins found clinically as the presence of a palpable, soft scrotal mass, could be associated with mild to moderate pain, and they can also be associated with infertility. The size of varicocele is variable according to the severity of the disease. It ranges from large palpable mass of veins easily felt by the patient to varicocele that is only discovered by ultrasound study called subclinical varicoele. The treatment of the large sized varicocele is recommended and known to cause relief of the symptoms and might cause improvement to the seminal fluid quality and the state of fertility while the subclinical varicoele treatment is still controversial as there are results of some studies that showed a significant improvement of fertility after surgical treatment otherwise the treatment in many centers is still not indicated. The study objectives were to determine the relationship between subclinical varicocel and male fertility parameters in addition to follow up treated subclinical patients to determine the effects of surgical treatment on the seminal fluid and fertility. Data analyzed for 122 patients included in this study , full comprehensive history was taken ,physical examination ,testicular color Doppler ultrasound examination , pre and post operative assessments of seminal fluid analysis also evaluation serum levels of some reproductive hormonal profile includes, Follicle stimulating hormone (FSH), Luteinizing hormone (LH) and Testosterone (T) in addition to the expression of FasL mRNA gene in seminal sperms of the patients with subclinical varicocele . The Doppler ultrasound was done to all included patients to measure the testicular volume and the accurate size of the dilated testicular veins to diagnose the subclinical cases , the veins diameter 2.5 mm was used as a cutoff point. Follow up was done for 60 patients of subclinical group pre and post varicocelectomy .Fifty healthy fertile male of similar age were included in this study as a control group.The study was done in male infertility clinic of Al - Yarmouk Teaching Hospital Baghdad, Iraq from the 1st of October 2013 to the end of December 2014 while the FasL expression of 60 samples of subclinical varicocele patients were studied in Manchester Metropolitan University . Health and science laboratories - UK. Results showed that the subclinical varicocele affects male fertility with a significant negative correlation between subclinical group and some of semen parameters including : sperm morphology, percentage of progressive motile sperms and also a significant positive correlation between sperm count and FasL gene. The results also supported the hypothesis of clinical varicocele effects on male fertility as there was a significant negative correlation with the total sperm count, percentage of progressive motile sperms and also there was a significant increase in FSH with decreased testosterone (T) and mild decrease in the testicular volume. From this study we can conclude that subclinical varicocele cause decrease in sperm count, motility and sperm morphology and to some extend hormonal serum levels but no significant changes for testicular volume. Samples of subclinical patients showed a significant expression of FasL RNA and the surgical treatment of such cases gave an improvement to the state of fertility.

اثار حبوب منع الحمل الفومية احادية الطور على فعالية عامل التخثر السابع ومستوى ثنائي ال دي - دايمر في النساء الاصحاء والبدينات == The Effect of Regular Monophasic Oral Contraceptive Pills on Factor VII Activity and D - dimer Level in Healthy and Obese Women

اسم المؤلف: اسراء سعدي عباس
اسم المشرف: هيثم احمد الربيعي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - الدم
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The combined oral contraceptive pill includes a combination of estrogen and progestin. Clinical and epidemiological studies indicate that the use of these pills is associated with an increased risk of thrombotic disorder including both deep vein thrombosis and pulmonary embolism.The pathogenesis of increased thrombotic risk with pills use is that the estrogen content in the pills has many effects on coagulation system that results in shifting of the hemostatic balance toward a prothrombotic state.Obesity is defined as abnormal or excessive fat accumulation that may impair health. Body mass index is commonly used to classify overweight and obesity. It is an independent risk factor for venous thromboembolism and increases the risk of thrombosis 2 - fold, since obese individuals have higher levels of several procoagulant factors. There may be an additional risk of thrombosis caused by venous stasis that also occurs with obesity. Oral contraceptive use in conjunction with obesity increases the risk of thrombosis about 10 - fold.Aim of the studyTo assess the level of FVII activity, D - dimer level, and other hemostatic changes in healthy non - obese and obese women on contraceptive pills and compare them to that found in normal healthy non - user women.Patient, materials and methodsThis case - control study included 50 females attending the family planning clinic at Baghdad Teaching Hospital of Medical City. TheyIIIwere regularly using monophasic regular dose estrogen containing combined oral contraceptive pills (Microgynon® ED Fe) for at least 3 months. Their ages were between 18 and 45 years. Females on pills were divided into 2 groups :  Non - obese group : enrolled 25 females with BMI of < 30 kg/m2 (15/25 females were overweight, and 10/25 were of normal weight) Obese group : composed of 25 females with BMI of ≥ 30 kg/m2Twenty five healthy, non - obese (16/25 were overweight and 9/25 had normal weight), age - matched non - pregnant females neither on pills, nor taking any hormonal therapy and having no history of malignancy or previous thrombosis, were assigned as a control group.Relevant clinical data were collected from all participants. Weight and height were measured (in kilograms and centimeters, respectively), and then the BMI was calculated accordingly for each participant.Platelet counts were measured by a hematology auto - analyzer (Cell - DYN, RUBY ABBOTT Diagnostic, USA). Prothrombin time, activated partial thromboplastin time, and factor VII activity were measured using semi - automated coagulometer (STart4®, DIAGNOSTICA STAGO/France). D - dimer levels were measured by turbidimetric immunoassay using an automated analyzer (ARCHITECT c4000, Abbott Diagnostics, USA).ResultsThere was significant reduction in prothrombin time in the non - obese, obese, and pills users groups compared to that in the control group (P= 0.014, 0.020, and 0.006 respectively), while the activated partial thromboplastin time was insignificantly reduced in all of these groups.Moreover 22% of pills user cases had shortened prothrombin time compared to the lower limit of prothrombin time in the control group (11.8 sec), and 8% of them were found to have shortened activated partial thromboplastin time compared to the lower limit of activated partial thromboplastin time in the control group (24.6 sec).The correlations between the duration of pills use (< 1 year and > 1 year) and prothrombin time and activated partial thromboplastin time showed statistically insignificant differences in both study groups.The factor VII activity in the non - obese, obese, and pills users groups were significantly higher than that of the control group (P= 0.041, 0.001, and 0.004 respectively). It had been observed that 22% of pills user cases had FVII activity above the highest value of activity that was found in the control group (95%). Also there was a significant inverse correlation between the prothrombin time and factor VII activity with P - value of 0.008.The D - dimer levels were found to be significantly higher in the non - obese and obese group compared to that of the control group (P= 0.029 and 0.038, respectively). The mean D - dimer of the pills users group was insignificantly higher than that of the control group, P value = 0.053.The platelet count was insignificantly increased in the non - obese group when compared with that in the control group (P= 0.106), while it was significantly increased in the obese and pills users groups compared with that in the control (P = 0.027, and 0.034, respectively). There were no statistically significant differences in the means of prothrombin time, activated partial thromboplastin time, factor VII activity, D - dimer level, and platelet count between the non - obese and obese groups (P > 0.05).

تقييم عدم تزامن انقباضية البطين الايسر لدى مرضى ارتفاع ضغط الدم ممن يمتلكون قوة ضخ ضمن المعدل الطبيعي == Echocardiographic assessment of Left Ventricular Dyssynchrony in Hypertensive Patients with Normal Systolic Function

اسم المؤلف: مروة طارق محمد
اسم المشرف: علي ال ياسين
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: صدى القلب
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: congestive heart failure,the majority of such patients have systemic hypertension. Recent studies have demonstrated Left Ventricular dyssynchrony among patients with heart failure and normal systolic function.The co - existence between Left Ventricular dyssynchrony and hypertension with normal systolic function (with no clinical evidence of heart failure), is less well understood.The Aim of study : To assess the Left Ventricular dyssynchrony among hypertensive patients with normal systolic function by using Tissue doppler imaging.To find out the associations between the LV dyssynchrony and other global echocardiographic findings like (LA volume index, LVmass index , LV sephericity and LV filling pressure E/E) .Patients and method Prospective case - control study conducted in Baghdad Teaching Hospital from 1st of June 2015 to 30th of May 2016 .Study included two groups of people, a 40 age_ matched healthy (control) group (group1) and 60 patients with established hypertension (group 2). A Complete 2 - D and TDI echocardiography studies with simulitnous ECG were performed for all patients. Examination involved LV septal and posterior wall thicknesses, internal dimensions, left atrial size, ejection fraction and tissue doppler derived waves velocities E', E/E.' Dyssynchrony was determined by measuring T - P max ( the maximal time difference from the onset of QRS to peak systolic velocity on TDI between any opposing LV wall in 3 apical views) .Results : The study included 40 age - matched control people, 27males (67.5%) and 13 females (32.5%) with a male to female ratio was 1.8 : 1, ranging from (42.4 - 58y) with mean age was (50.2 ±7.8y ) (group 1) and 60 hypertensive patients, 38 males (63.3%) and 22 females (36.7%) with a male to female ratio was 1.7 : 1, ranging from (48.5 - 66.5y) with mean age of (57.5± 9.0 y) (group 2) .Left Ventricular dyssynchrony was identified in 20 of 60 patients (33.3%) .Dyssynchrony had no significant association with age and BSA. Dyssynchrony was significantly associated with LA volume index (r = 0.61, p=0.001), LV mass index (r=0.52 ,p=0.001) , LV sphericity index (r= 0.5, p = 0.003) ) and LV filling pressure (r=0.6 , p value=0.001) . Dyssynchrony had significant negative correlation with ( E) velocity (r= - 0.7 ,P =0.001) .

شيوع متلازمة الم الليف العضلي بين عينة من النساء العراقيات المصابات بالعقم == Prevalence of Fibromyalgia among a Sample of Women with Infertility

اسم المؤلف: رسل عبد الامير شاكر
اسم المشرف: نزار عبد اللطيف جاسم | الاء حازم بدر
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Fibromyalgia is the current term for chronic widespreadmusculoskeletal pain for which no alternative cause can be identified, itfrequently affects women of fertile age. Fibromyalgia is a debilitating andfrustrating syndrome that is usually triggered by psychological orphysical stressful events. Infertility is failure to achieve pregnancy in a 12month period for patients under 35 years of age and failure to conceive ina 6 months period for the over 35 years that causes major psychosocialimpact on infertile person life whether male or female.Aims of the studyTo estimate the prevalence of fibromyalgia among a sample ofinfertile women; and to study its correlation with age, duration ofmarriage, and duration and type of infertility.Patients and MethodsA cross sectional study was conducted in Kamal Al - SamarraeeInfertility Center & Infertility Clinic in Baghdad Teaching Hospital on202 infertile women. Personal information, sociodemographic featuresand obstetrical history of each patient were recorded and fibromyalgiawas diagnosed according to 2012 Canadian Guidelines for Diagnosis andManagement of Fibromyalgia.ResultsFibromyalgia was reported in 48 women (23.8%). There wassignificant association between fibromyalgia and age (P=0.023), longerduration of marriage (P=0.001) and longer duration of infertilityVIII(P=0.04), but no significant association with type of infertility whetherprimary or secondary(P=0.32).ConclusionsThe prevalence of fibromyalgia among infertile women was higher than reported in general population and its occurrence was significantly associated with age, longer duration of marriage and infertility.

نوعية الحياة اثناء العلاج الشعاعي الخارجي للراس والرقبة == Quality of Life During Head and Neck External Beam Radiotherapy

اسم المؤلف: علي غالب محمود
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Worldwide, head and neck carcinoma is the sixth most common cancer accounting for 2.8% of all malignancies. Radiotherapy plays an integral role in their management and it is used in approximately 60 - 70% of cases. Even withrecent advancements in the radiation therapy it is still associated with certain treatment - induced reactions that may affect the quality of life of patients during and after treatment. This study aim to evaluate the radiation induced early side effects in patients receiving external beam radiotherapy for the treatment of a head and neck carcinoma.Patients and methods This study is an observational descriptive cross - sectional survey, with the target population being patients whom had external beam radiotherapy for a head and neck tumor whom are within 180 days from starting treatment. Forty patientswere included, all received external beam radiotherapy to the head and neck region at the Oncology Teaching Center / Radiation Therapy Department at the Medical City Complex with either a radical or adjuvant intent. The data were collected from 1st of January 2016 to 1st of March 2016. All patients were evaluated for the early side effects of external beam radiotherapy to the head and neck region including fatigue, skin dermatitis, voice changes, xerostomia, altered taste, oral mucositis, and dysphagia. As well as the incidence of patients who required a tracheostomy and/or a gastrostomy after initiation of radiotherapy, and that of those who developed a significant weight loss (>10% of their initial weight).ResultsIn this study, dysphagia occurred in 88% of the studied patients, only 1 patient (3%) developed a grade 4 dysphagia and required a gastrostomy. Of the 40 patients who were studied, 14 patients (35%) had a significant weight loss ≥10% of their initial weight. Xerostomia occurred in 85% of the studied patients, while fatigue occurred in 83% of the studied patients. Oral mucositis and skin dermatitis had similar incidences, each occurring in 63% of the studied patients.Voice changes and altered taste occurred in 55% and 53% of the studied patients respectively.ConclusionsDysphagia and xerostomia were the two most common early side effects of radiotherapy to the head and neck region. More than half of patients with dysphagia had a grade 2 or higher dysphagia, and about three - quarters of those with xerostomia had a grade 2 or higher xerostomia. To spare the salivary glands and pharynx during radiotherapy plan preparations as much as possible is highly recommended to reduce those two side effects.Although fatigue ranked third in incidence after dysphagia and xerostomia, the majority of those patients complained of only a mild fatigue over baseline.Skin dermatitis and oral mucositis had a similar incidence occurring in 63% of the studied patients. More than half of those patients had only a mild reaction (grade 2 or less). Regular use of soothing agents is recommended to counteract these two side effects.

تاثير القلق او الاكتئاب او كلاهما على الالم والتيبس والوظيفة البدنية لعينة من المرضى المصابين بالفصال العظمي الاولي للركبة : دراسة مقطعية عرضية == Impact of Anxiety and/or Depression symptoms on Pain, Stiffness, and Physical Function in Patients with Primary Osteoarthritis of The Knee : A Cross Sectional Study

اسم المؤلف: عياء عبد الامير محمد
اسم المشرف: سامي سلمان شهاب
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Osteoarthritis is the most common articular disease of thedeveloped countries and a leading cause of pain and disability. The presenceof anxiety and depression symptoms in patients with osteoarthritis canadversely affect pain and physical function. There is also a proposed adverseeffect of anxiety and depression symptoms on joint stiffness.Objective : To examine the effect of anxiety and/or depression on pain,stiffness, and physical function in patients with knee osteoarthritis.Patients and Methods : A cross - sectional study was conducted on a totalof 101 patients with diagnosis of primary knee osteoarthritis according tothe American College of Rheumatology criteria. Each patient completed theWestern Ontario and McMaster Universities Osteoarthritis (WOMAC) Indexand the Hopkins Symptoms Checklist - 25 for anxiety and depression (HSCL - 25). The presence of anxiety and/or depressive symptoms was determined,and their effects on the WOMAC scores were assessed.Results : According to the study, 83.2% of patients were found to haveanxiety and/or depression symptoms while only 16.8% have no symptoms ofthese disorders. Patients with anxiety symptoms only had significantlyhigher mean pain score than those with none (p. value = 0.042). while theeffect of anxiety symptoms only on the mean physical function, stiffness,and total WOMAC scores was not statistically significant, (p .value = 0.18,0.87, 0.08) respectively. Patients with depression symptoms only hadsignificantly higher mean pain, physical function, and total WOMAC scoresas compared with those with none, (p .value = 0.044, 0.021, 0.013)respectively. While there is no statistically significant effect for the presenceof depression symptoms only on mean stiffness score (p. value = 0.094).Patients who have symptoms of both anxiety and depression had higherABSTRACTVIImean pain, physical function, stiffness, and total WOMAC scores comparedwith those with none , (p. value <0.001, <0.001, =0.013, <0.001). The totalnumber of patients with anxiety and/or depression symptoms hadsignificantly higher mean pain, physical function, stiffness, and totalWOMAC scores as compared with those with none, (p. value <0.001, <0.001, =0.01, <0.001) respectively. After performing multiple logistic regressions to control any confounding effect, the pain, Stiffness and total WOMAC scores were significantly associated with the presence of anxiety and or depression, (P. value<0.05), after adjustment for other variables.Conclusions : 1. According to anxiety and depression scores most of the patients with KOA had anxiety or depression symptoms or both.2. The presence of anxiety and/or depression symptoms was associated with significantly higher pain, stiffness, and total WOMAC scores, but the association with physical function scores was not significant.

تقييم المعرفة حول هشاشة العظام في عينة من النساء البالغات في بغداد, العراق, 2016 == Assessment of Knowledge about Osteoporosis among a Sample of adult Women in Baghdad, Iraq, 2016

اسم المؤلف: هند صلاح محمد
اسم المشرف: فارس حسن اللامي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب العائلة
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Osteoporosis
  • Iraq
  • OKAT
  • Adult women
الصفحات الاولى:
المستخلص: Background : Osteoporosis is a global growing health problem and contributor of mortality and morbidity. It causes a significant personal and societal impact and increases the burden of healthcare services. The objective of this study is to assess the level of knowledge about osteoporosis among a sample of adult women in Baghdad, Iraq, 2016.Methods : A cross - sectional study conducted on a sample of adult women in Baghdad (age ≥ 25 years old) who attended consulting clinics in Baghdad Teaching Hospital. The estimated sample size was calculated to be 384. We used a questionnaire to gather socio - demographic data and life habits that may affect osteoporosis risk, and the Osteoporosis Knowledge Assessment Tool (OKAT) to measure osteoporosis knowledge of women. The maximum score of the total knowledge was out of 100 points. The score had been categorized as follow weak (<50%), moderate (50% - 75%), good (>75%).Results : The mean level of knowledge scores is 53.53±13.04, and the range is 5 - 85%. Around 70% had correctly answered half of the questions. On Binary analysis, we found the level of education and source of information were the only significant risk factors (p value=0.001). On application of Logistic regression analysis; educational status was the only significant (OR=1.41, 95% CI : 1.2 - 1.7).Conclusion : Iraqi women had moderate level of knowledge about osteoporosis.More work is needed to ensure more women having the right knowledge, attitudes and practices.

التصنيف الجزيئي لعينة من مرضى سرطان الثدي العراقيين وعلاقته بحالة المرضى السريرية والنسيجية : دراسة وصفية == Molecular Classification of Iraqi Breast Cancer Patients and Its Correlation with Patients’ Profile (Observational Study)

اسم المؤلف: مصطفى خضير جاسم
اسم المشرف: منور عبد الاله النقاش
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Iraqi breast cancer
  • molecular classification
  • Luminal B like.
الصفحات الاولى:
المستخلص: Background : Breast cancer is a complex, multifaceted disease encompassing a great variety of entities that show considerable variation in clinical, morphological and molecular attributes. Traditional classifications including histological assessment and clinical staging are used to guide patient management. In recent years, there has been exponential progress in molecular analysis with profound implications for our understanding of breast cancer biology and, hence, classification.Objective : The aim of this study to assess Iraqi breast cancer patients’ clinical profile (tumor size, lymph nodes, etc…). Evaluate patients’ molecular profile (Estrogen receptor, Progesterone receptor, HER2/neu and Ki - 67).Patients & Methods : This is a cross - sectional descriptive study was done in Baghdad oncology teaching hospital from the 1st of December 2015 to the 1st of April 2016, carried on 100 breast cancer female patients with their age range from 27 to 73 years old and with their histopathology reports and immunohistochemical (IHC) results including Estrogen (ER), Progesterone (PgR), HER2/neu and Ki - 67. The patients in this study underwent surgical intervention either by a biopsy or mastectomy with axillary clearance, and the formalin - fixed paraffin - embedded tissue blocks were sent to the hospital’s laboratory for H&E and IHC.Results : The mean age ± SD (51 ± 10) years, the highest incidence of breast cancer among patients in 5th (40 - 49 years) and 6th (50 - 59 years) decades of life and each group is (32%), while the lowest incidence in 3rd decade of life (2%). In regards of tumor size, T1 was (28%), T2 was (56%), T3 was (15%) and T4 was (1%). According to lymph nodes, Nx was (33%), N0 was (16%), N1 was (25%), N2 was (17%) and N3 was (9%). ER and PgR values were observed in 74% and 75% respectively, regarding ER receptor there were 14 patients (14%)XIwith +1, 17 patients (17%) with +2, 43 patients (43%) with +3, and 26 patients (26%) with negative score, while PgR receptor there were 11 patients (11%) with +1, 20 patients (20%) with +2, 44 patients (44%) with +3, and 25 patients (25%) with negative score. In regards of the immunohistochemicetry of Her2/neu there were 26 patients (26%), 28 patients (28%), 30 patients (30%) and 16 patients (16%) for score 0, +1, +2, +3 respectively, score +3 considered positive, score 0, +1 considered negative, while +2 equivocal, and 31 patients (31%) with Ki - 67 <14, while 69 patients (69%) with Ki - 67 ≥14. There was a negative correlation between the tumor size and Her2/neu, with statistically significant P value = 0.013, and there was a weak correlation between the lymph nodes and the tumor size with insignificant P value = 0.181. Also there was a strong correlation between ER and PgR with highly significant P value < 0.0001, and a strong correlation between ER and Her2 with significant P value = 0.009. On the other hand, our results reported a weak correlation between PgR and Her2 with insignificant P value = 0.165. Luminal B - like were 53 patients (53%), Luminal A - like were 29 patients (29%), Triple negative were 15 patients (15%) and HER2 overexpressed were 3 patients (3%). The highest frequency was seen among patients with Luminal B - like followed by Luminal A - like and triple negative, while the lowest frequency was seen among patients with HER2 overexpressed.Conclusions : Highest incidence of breast cancer in the studied patients was seen ≥ 40 years in the 5th & 6th decades of life, and the most common tumor size was T2, beside the most common assessed axillary lymph nodes were N1. Luminal B - like was the most common molecular subtype of the breast cancer patients in the studied group mostly due to high Ki - 67 index. Most of the breast cancer patients in the current study were ER and PgR (Hormonal) positive 74%, 75% respectively

تقييم الاضرار الجانبية المبكرة للعلاج الشعاعي في مرضى سرطان الثدي == Assessment of early side effects of radiotherapy in breast cancer patients

اسم المؤلف: ايلاف علي حسين
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Breast cancer
  • Conventional fractionation
  • Hypofractionation
  • Radiation Dermatitis
الصفحات الاولى:
المستخلص: سرطان الثدي هو السرطان الاكثر شيوعا" عند النساء في العراق والعالم. العلاج الشعاعي يلعب دورا" اساسيا" في علاج سرطان الثدي. عند الممارسة العامة لعلاج الاورام بالاشعاع, سرطان الثدي نموذجيا" يشكل حوالي 25% من مجموع حالات المرضى.هذا يجعل فهم ماهية الضرر المتوقع من الاشعاع لسرطان الثدي وعلاجه ذو اهمية اولوية بما انه يؤثر على عدد قيم من المرضى يوميا".الاضرار الجانبية الناتجة عن الاشعاع في مرضى سرطان الثدي يمكن ان تنقسم الى اضرار جانبية مبكرة (حادة ومتوسطة) واخرى متاخرة. الاضرار الجانبية المبكرة تحدث خلال مدة المعالجة وحتى ستة اشهر بعد انتهاء العلاج.هذه الدراسة هي مسح استبياني ((cross - sectional survey مع مكونات تحليلية تهدف لتقييم الاضرار الجانبية المبكرة للعلاج الشعاعي الخارجي المساعد في 60 مريض بسرطان الثدي عولجوا في قسم العلاج الشعاعي في مستشفى الاورام والطب النووي في مدينة الطب من فترة كانون الثاني لنيسان 2016 بعد استئصال الثدي (44 مريض) او عمليات الحفاظ على الثدي (16 مريض).الاضرار الجانبية الناتجة عن الاشعاع الاكثر حدوثا" كانت تهيج جلدي 81.6%, ارهاق 70%, الم في المناطق المشععة 66.6%, حرقة البعوم 58.3%, غثيان 41.6%, صعوبة البلع 35% وتورم الذراع 28.3%.كان هناك فرق ذا قيمة احصائية بين حدوث التهيج الجلدي بين جرع الاشعاع الثلاث المستحدمة. تهيج الجلد الشديد (الدرجة الثانية والثالثة) كان حادثا"بصورة قيمة اكثر في المرضى المستلمين لجلسات الشعاع الاعتيادية (5000 cGy/25 F (CF)) منه في المرضى المستلمين لجلسات العلاج الشعاعي المختصرة (hypofractionation). وهذا متوافق مع المصادر.نسبة حدوث التهيج الجلدي كانت اكثر ايضا" في المرضى المعالجين بعمليات الحفاظ على الثدي 87.5% منها في الذين استاصلوا الثدي 79.5%, لكن العلاقة لم تكن ذات قيمة احصائية.استنتجنا ان هناك الكثير من الاضرار الجانبية الحادة تحدث بعد العلاج الشعاعي لمرضى سرطان الثدي ليس منها فوق الدرجة الثالثة. ولكنها تؤثر على جودة الحياة الصحية ويجب تجنبها ان امكن. تهيج الجلد كان اكثر اضرارالاشعاع الجانبية شيوعا وكان متعلقا بتقسيم الجرع. الارهاق كان الثاني وكان ذو صلة بمرحلة المرض. | Background : Breast cancer is the commonest cancer in women In Iraq and globally. Radiation plays an essential role in the management of breast cancer. In a general radiation oncology practice, breast cancer comprises approximately 25% of total patient caseload. This makes understanding what type of toxicity to expect from radiation for breast cancer and its management of prime importance since it affects significant numbers of patients daily. Radiation induced side effects (RISE) in breast cancer patients can be divided into early (acute and subacute) and late side effects. Early radiation toxicities occur during treatment time and up to six months after treatment has finished. Objectives : assessment of the early side effects of adjuvant external beam radiotherapy (EBRT) in breast cancer patients.Patients and Methods : A cross sectional survey with analytic component conducted on 60 patients treated in the radiotherapy department of oncology teaching hospital of medical city from the first of January to the 30th of April 2016 after mastectomy (44 patients) or breast conserving surgery (BCS) (16 patients).Results : The most prevalent RISE were radiation dermatitis (81.6%), fatigue (70%), pain in the irradiated area (66.6%), sore throat (58.3%), nausea (41.6%), dysphagia (35%), and arm edema (28.3%). There was a significant difference between prevalence of dermatitis with different radiation doses used. Dermatitis was more prevalent with conventional fractionation (CF), than in hypofractionated radiotherapy. The prevalence of dermatitis was also more in patient treated with BCS (87.5%) than those who had mastectomy (79.5%), but this relation was not statistically significant. Fatigue was found to be related to disease stage.Conclusion : Much acute toxicity were developed after radiotherapy to breast cancer patients, none of them was above grade 3; however they affect health related quality of life (HRQL) and should be avoided if possible. Dermatitis was the most common acute toxicity of radiotherapy in breast cancer patients. It was related to dose fractionation. Fatigue was the 2nd common. It was correlated with disease stage.

الحالة السريرية والمرضية النسيجية لمرضى سرطان الرئة في العراق وقت عرض الحالة == Clinical And Pathological Profile Of Iraqi Lung Cancer Patients At Time Of Presentation (An Observation Study)

اسم المؤلف: هالة ساطع طه
اسم المشرف: منور عبد الاله النقاش
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الخلفية العلمية : في جميع انحاء العالم يمثل سرطان الرئة 13% (1.6 مليون) من مجموع حالات السرطان و18% (1.4 مليون) من الوفيات الناجمة عن السرطان على اساس تقديرات عام 2008 وسرطان الرئة في العراق سبب شائع في للوفاة في كلا الجنسين اهداف الدراسة : التقييم السريري والتصويري للحالة المرضية وايجاد علاقة بين الانواع الفرعية النسيجية المرضية وغيرها من معلومات المريض .طريقة البحث : تعتبر هذه الدراسة من نوع دراسة المراقبة (دراسة مقطعية) تتكون من 60 مريض يعانون من مرض سرطان الرئة متوسطة اعمارهم 60 عام 38 ذكور و22 اناث (نسبة الذكور الى الاناث 1.7 : 1) تم جمع حالات المرضى من العيادة الاستشارية في مستشفى الاورام التعليمي في مدينة الطب من شهر كانون الثاني الى شهر نيسان 2016 تم تقييم جميع الحالات واجراء الفحص السريري والتشخيصي والنسيجي.النتيجة . تم دراسة (60) مريضا اثبتت اصابتهم بسرطان الرئة سن الحد الادنى للمرضى هو 32 سنة والحد الاقصى 81 سنة بمتوسط عمر 60 عام 38 من الذكور و22 اناث معظم المرضى لديهم صعوبة التنفس في وقت العرض (21%)، ونفث الدم (20%). تليها السعال (16 %). اما المكان التشريحي الاكثر اصابة بسرطان الرئة الفص العلوي الايمن 14 (23%). ثم الفص العلوي الايسر 9 (15%). يعد الغسل القصبي اختبار الخلايا 22 (36%) اكثر وسيلة مستخدمة لتشخيص المرض يليها فحص الخلايا المسحوبة بواسطة الابرة الناعمة 9 (15 %)، طموح السائل الجنبي 8(13.3%) الخزعة الاستئصالية 7 (11.7%)، الخزعة الجراحية 5 (8.3%)، علم خلايا البلغم 4(6.7%)، الخزعة الماخوذة بمساعدة الجهازالطبقي المقطعي 2 (3.3%) النتيجة التشريحيةالمرضية الرئيسية هي سرطان الخلية الحرشفية (41.7%) ثم الغدية (36.7%) بعدها سرطان الرئة صغير الخلية ، ورم الظهارة المتوسطة (8.3%) اخيرا يمثل سرطان الخلايا القشرية هو الشائع في الذكور 20(52.6%) ولكنه في الاناث 5 (22.7%) ومع ذلك السرطانات الغدية هي الاكثر شيوعا في الاناث 12 (54.5%) من الذكور 10 (26.3%) هنالك علاقة طردية بين نسبة حدوث سرطان الرئة من نوع الخلايا الصغيرة مع التدخين حيث ان جميع المرضى هم مدخنين بينما في الخلايا الحرشفية فان (47.8%) هم مدخنين (P=0.003) اغلب المرضى لديهم ورم خبيث منتشر وقت تشخيص الحالة (56%) و(33.3%) لديهم استسقاء رئويالاستنتاجات : 1 - اكثر عارض مرضي يعاني منه مرضى السرطان في العراق هو ضيق التنفس ثم النفث الدموي.2 - الفص العلوي الايمن هو الاكثر اصابة بالمرض 3 - الغسل القصبي وفحص الخلايا هو اكثر طرق التشخيص شيوعا 4 - سرطان الخلايا الحرشفية هو النوع النسيجي المرضي السائد في الذكور بينما سرطان الرئة من نوع الغدي هو السائد في الاناث 5 - هناك علاقة ذات دلالة احصائية بين سرطان الخلايا الحرشفية والتدخين (P=0.003) واغلب المرضى يعانو من مراحل متقدمة في وقت عرض الحالة | Background; Carcinoma of the lung is currently the leading cause world wide of death . The disease has become an epidemic as incidence rates and lung cancer deaths have risen dramatically over the last century, Throughout the world, lung cancer accounts for 13% (1.6 million) of the total cases of cancer and 18% (1.4 million) of the cancer - related deaths based on 2008 estimates. Among males, lung cancer is the most commonly diagnosed cancer and leading cause of cancer death. Among females worldwide, it is the fourth most commonly diagnosed cancer and the second leading cause of cancer death.Aim of study : 1 - Identify the most common stages of lung cancer at time of presentation2 - Estimate the anatomical distribution of lung cancer according to histopathological subtypes3 - Find the acorrelation between histopathological subtypesAnd other parameters of patient profilePatients &Methods : Methods;An observation study ( A cross sectional study) of 60 patients with lung cancer with mean age of 60 years old.38 male;22 female (male : female 1.7 : 1). cases were collected from consultant clinic at the Oncology Teaching Center in Medical City. The data were collected from 1st January to 30th of April/2016. All patients were evaluated from history ,physical examination ,sent for investigations &review of histopathology samples.Results : A total of 60 lung cancer patients were studied,mean age of patients 60 yrs old , male : female ratio 1.7 : 1 ,most patients are smoker, Sequamous cell carcinoma is commonest type (41.9% ) of all patients, and its male predominant (33.3%) .Most patient diagnosed by bronchial wash and cytology (36%) ,Right upper zone is commonest site of malignancy (23.3%) ,most patients presented in advance stage and metastasis (56%).Conclusions*Lung cancer is commonest cause of cancer related death.*Proper stage of disease is recommended as mediastinscopy found 15% of occult lymph node metastasis in radiologically normal nodes.*Most patients have metastasis at time of presentation so we can use new radiological modalitiy to diagnosed occult metastasis.*use molecular biology to proper diagnose the histopathologiac subtypes and identify the response to treatment and give a prognosis idea*Active surveillance of primary small lung lesion

العوامل المرتبطة مع سرطان الثدي وتاثيراتها في عينة من المرضى لمستشفى الامل الوطني لعلاج السرطان في بغداد == Factors associated with Breast Cancer Impact in a sample of Al - Amal National hospital for Cancer management in Baghdad

اسم المؤلف: اسامة مدحت لفتة
اسم المشرف: احمد سمير النعيمي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Breast cancer (BC) known to be the most common cause of cancer - related death among females with excess of more than a million inflicted with this disease every year. In Iraq, breast cancer is the most common type of malignancy among the Iraqi population in general. The disease affects physical and mental health among breast cancer survivors. The true impact of a successful medical intervention could be understood by the degree to which the treatment has a positive influence on patient’s immediate and /or future well - being. Assessment of quality of life among breast cancer is vital to identify area of concerns to the patient and health professional, and to suggest means to improve disease outcome and reduce patient’s suffering. The current study aimed at measuring the impact of Breast Cancer on different aspects of health related quality of life. In addition, to studying the association between the impact of breast Cancer and sociodemographic characteristics or treatment modalities.A cross - sectional study was conducted on a total of 250 randomly selected females with an established diagnosis of breast cancer attending Al - Amal National hospital for Cancer management in Baghdad. Data collection took place during the period from January to April, 2016, each participant was asked to fill The questionnaire composed of three parts : The first one covered sociodemographic characteristics including : age, gender, educational attainment, marital status, living arrangement, finical status, BMI and blood pressure. The second part contained the ABCIS (Arabic Breast Cancer Impact Scale) with 14 questionnaire items. The third part of the questionnaire gathered data about disease associated factors like duration, treatment modalities. The answers that reflect the impact of the disease on specific life domains were anchored to a 5 points Likert - scale type rating scale. It ranges from large extent to no impact. Higher rating reflects higher negative impact. In addition, the importance of each domain rated on 4 points likert - scale ranges from very important to not important. Higher rating reflects greater importance.Breast cancer had negative impact on patients quality of life. The psychological domain was the most affected among the three domains of quality of life, while theviisocial domain was the least affected. The retest part of the study supported a high reliability for the tested instrument among Iraqi Breast Cancer patients. A quarter of study subjects described the quality of their life as poor. This group of females is at risk for bad prognosis and deterioration of their conditions later on.The study failed to detect an association between type of treatment (whether radio or chemo - therapy) and negative impact of breast cancer on quality of life. Most cancer patients in Iraq fail to cope with the new events and changes in their body image and daily activities that resulted from their disease, neither in their social or occupational life. This might be related to the lack of the psychological therapy and rehabilitation program, which should be provided in all stages of management.

تصنيف المرضى العراقيين المصابين بالاورام العصبيه الغديه وتقدير مدى استجابتهم لعقارالساندوستاتين (الاوكتيريوتايد) == NEUROENDOCRINE TUMORS CLASSIFICATION AND RESPONSE TO LONG ACTING SOMATOSTATIN ANALOGUE; AN IRAQI EXPERIENCE

اسم المؤلف: مروة خالد عبد الفتاح
اسم المشرف: منور عبد الاله النقاش
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The lack of studies regarding the incidence of neuroendocrine tumors (NETs) is related to the rarity of these tumors (25/1,000,000). Chromogranin A is a useful tumor marker for NETs diagnosis & follow - up. Octereotide LAR is an established treatment for NETs by both providing symptomatic relief & inhibiting tumor growth. However, studies regarding incidence of NETs & their response to SAS - LAR are still insufficient.Aim of studyTo shade the light on the incidence of NETs, the clinico - pathologic characteristics of Iraqi patients with NETs & their response to long acting Octereotide.Patients & methodsThis is a cross - sectional observational study that was conducted in Oncology teaching hospital/medical city complex using patients’ follow - up sheets. Data recruitment included all NET patients diagnosed after October 2013 to April 2016.ResultsIn our registry, 38 patients were recorded; most patients (60.5%) were over the age of 50 years with male to female ratio (1.2 : 1). We found the gastroenteropancreatic tract being the most common primary organ followed by pelvis . With respect to the GI tract we found that pancreas (26.3 %) was the commonest primary organ. Metastatic disease at presentation was found in (44.7%) of patients with the Liver (15.8%)was the most common metastatic site.Notably, most of our patients presented with G3 disease (44.7%) & (13.2%) with G1 . Serial CgA tests were performed in (17/28) patients used SAS - LAR, with a change in mean value from (225.3 U/L) pre - using the agent to (17.5 U/L) two months after use & to (8.7 U/L) four months after use(p=0.001) while the change in mean of CgA level was from (205.9 U/L) to (200.9 U/L) in 10 patients who did not use octereotide.(p=0.2). After a period of 2 years ,the median time of remission following SAS - LAR administration was 3 months compared to 7 months in patients received other modalities of treatment. In our study, a statistically significant difference was demonstrated between the two groups of patients.(p=0.003).Conclusion Plasma CgA is the most reliable marker for NETs, reflecting the clinical evolution of the disease. Aids in diagnosis & response assessment to different therapies.Octreotide LAR provides symptomatic response & contributes to disease stabilization & tumor regression in both functional & non functional NETs.1 - INTRODUCTION Neuroendocrine tumors are thought to arise from cells throughout the diffuse neuroendocrine system that is composed of peptide - and amine - producing cells that may secrete different hormones depending on the site of origin. NETs are composed of monotonous sheets of small round blue cells with uniform nuclei and cytoplasm(1). They compromise a broad family of tumors, the most common of which are carcinoid tumors (most commonly arise in the lungs & bronchi, small intestine, appendix rectum, or thymus)& pancreatic NETOther neuroendocrine tumors arise from parathyroid, adrenal, pituitary gland, & in calcitonin - producing cells of the thyroid (causing medullary thyroid carcinoma)( 2).Most NETs seem to be sporadic; risk factors for sporadic NET are poorly understood. Risk factors for the development of midgut carcinoid tumors include age, male sex, and increased body mass index, and menopausal hormone therapy (1).NET may also arise in the context of inherited genetic syndromes, include multiple endocrine neoplasia (MEN) types 1& 2 (2).The incidence of gastrointestinal (GI) NETs is 6.2 per 100,000 populations and has been steadily increasing. The increasing incidence of NETs reportedIn many studies is likely multifactorial and includes increased awareness and improved endoscopic methods of detection.As these tumors are indolent and patients survive a long time, the prevalence is quite high, making them the second most prevalent GI tract tumor, second only to colon cancer. Some are clinically silent and have been detected only at autopsy (incidence 8%). Further ,patients with GI NETs have a higher risk of other noncarcinoid primary tumors. The overall 5 - year survival rate of all patients with GI NETs is 28.5%.(1) Of all NETs ∼25% are located in the respiratory tract. Typical carcinoids (TCs) comprise ∼1% - 2% and atypical carcinoids (ACs) only 0.1% - 0.2% of pulmonary neoplasms. According to the surveillance, epidemiology and end results program (SEER) database from 2003, the combined incidence has been 1.57/100 000 inhabitants . The prevalence of thymic NET is ∼3% of the total number of NETs at all sites. In the last SEER database, a reported incidence of thymic NETs is 0.02/100 000 population per year . They constitute ∼5% of all thymic tumors. Both bronchial and thymic NETs may be part of multiple endocrine neoplasia type 1 syndrome (MEN - 1, 5% - 15%). The median age at diagnosis for bronchial NETs is 64 years and for thymic NETs 59 years.(3) The incidence of G1NET increased from 2.0 to 3.0; there was a large increase in G2NET from 0.01 in 1990 to 0.2 in 2010, and of the G3 - LCNET from 0.01 to 1.8, respectively. In G3 - SCNET incidence in men decreased from 21.3 to 10.1, whereas in women it increased from 4.5 to 7.7.(4).

تاثير عمر الام على نتائج الحمل == Effect of maternal age on pregnancy outcome

اسم المؤلف: حلا نعمان محمدعلي
اسم المشرف: جواد كاظم الديوان
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب العائلة
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: خلفية البحث : في العقود القليلة الماضية ،كان هناك تاخير في الحمل الاول ، ومعدل عمر النساء في وقت الولادة تزايدت. يرافق المراهقات الحوامل والحوامل المتقدمات بالعمرمضاعفات اثناء الحمل والولادة. هدف الدراسة : لدراسه تاثير عمر الام على صحه الام والوليد .المنهجية : دراسة مقطعية اجريت في مستشفى بغداد التعليمي للفترة من بداية شهراذار وحتى بداية شهر حزيران من سنة 2016 ،العينة متكونة من( 500امراة) اختيرت بطريقة العينات العشوائية المنتظمة من ملفات المرضى في قسم الاحصاء .تمت جمع المعلومات من قبل الباحثة من فايلات المرضى اللذين دخلوا او رقدوا في ردهات قسم النسائية لسنة 2015 ، ثم تم تصنيفهم حسب العمر الى ستة فئات عمرية المجموعة(<20 )، المجموعة (20 - 24 ) ،المجموعة (25 - 29) ،المجموعة (30 - 34 ) المجموعة(35 - 39)،المجموعة (40≤) .النتائج : اظهرت الدراسة بان هناك فروق ذات دلالة احصائية بين المجاميع العمرية المختلفة ،بالنسبة لوجود ارتفاع ضغط الدم اثناء الحمل ،داء السكري الولادة المبكرة ،وزن الوليد ،التشوهات الولادية ، وفاة الجنين داخل الرحم ،وطريقة الولادة. ولايوجد فروق ذات دلالة احصائية بالنسبة لوجود الاسقاط ،ولادة جنين ميت ،فقر الدم ،والحمل المتعدد. الاستنتاج : اثبتت الدراسة ان مضاعفات الحمل والولادة والمشاكل المتعلقة بالجنين عند الولادة تكون نسبتها اعلى عندالمراهقات الحوامل والنساء المتقدمات بالعمر . | Background : In the last few decades, there has been a delay in first - time pregnancies, and the average age of women at the time of delivery has increased in many countries. Teenage and advanced maternal ages are associated with adverse pregnancy outcomes.Objective : To demonstrate the effect of maternal age on pregnancy outcomes in different age groups mothers.Subjects and methods : Across sectional study was conducted in Baghdad Teaching Hospital, data was collected in obstetric \gynecology department from 1st of March until 1st of June 2016 .Total of 500 women were included in the study using the systemic random sampling, every 10th case was selected, then divided into six age groups, a list of information was taken from hospital record at statistic department.Results : The results showed that there was statistically significant association among different age group, regarding presence of pregnancy induced hypertension, diabetes mellitus, preterm delivery, birth weight, congenital anomalies, IUD, mode of delivery (p value<0.05). Interestingly there was no statistically significant association regarding presence of fetal loss (miscarriage, stillbirth), anemia, and multiple pregnancies (p value> 0.05).Conclusion : Maternal and neonatal complications are higher during the teenage years and advanced maternal age.Keywords : Maternal age, outcome of pregnancy

دور فحص المرونة وسرعة الموجات المقصوصة في التفريق بين الاورام الحميدة والخبيثة في الثدي == USE OF SHEAR WAVE ELASTOGRAPHY TO DIFFERENTIATE BETWEEN BENIGN AND MALIGNANT BREAST MASS

اسم المؤلف: اوان حكمت محمد
اسم المشرف: ليث احمد خلف
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة التشخيصية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Shear wave elastography is a new method of obtaining elastography images based on the combination of a radiation force induced in a tissue by an ultrasonic beam and an ultrafast imaging sequence capable of catching in real time the propagation of the resulting shear waves.Aim of studyTo assess the performance of shear wave elastography in differentiating between the malignant and benign breast tumors. Patients and Methods A cross sectional study carried out in Breast Clinic at Oncology Teaching Hospital - Baghdad Medical city for period from 1st of November, 2015 to end of June, 2016 convenient sample of 80 women with suspected breast tumor. After full history and examination, enrolled women were examined with ultrasound by the researcher with help of Radiologist.ResultsA highly significant association was observed between women with BIRADS V and high shear wave elastography ratio (p<0.001). Women with BIRADS V had significantly malignant fine needle aspiration findings of breast (p<0.001) and women with high shear wave elastography ratio were significantly had malignant FNA findings (p<0.001). The cutoff shear wave elastography ratio of 3.75 had good validity results (87% sensitivity, 82.4 % specificity).Conclusions Shear wave elastography is non - invasive reliable diagnostic method facilitating characterization of breast tumor.

العلاقة بين متلازمة الالم الليفي العضلي والبهاق : دراسة مقدمة الى كلية الطب - جامعة بغداد - قسم الامراض الباطنية == Relationship Between Fibromyalgia Syndrome and Vitiligo

اسم المؤلف: علا سفير خضير
اسم المشرف: عمار فيصل حميد
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Fibromyalgia syndrome (FMS) is a common, chronic, and highly disabling syndrome characterized with chronic widespread pain, fatigue, sleep disturbances, cognitive dysfunction and mood disorders. Vitiligo is an acquired pigment disorder which causes disfigurement to skin and negative effect on quality of life (QOL) for patients. There is no previous study on relationship between FMS and vitiligo.Objective : To assess relationship between FMS and vitiligo in a sample of Iraqi patients and to evaluate the predictors of this relationship if present.Patients and methods : A case controlled study involved 100 Iraqi patients with vitiligo and 200 healthy individuals matched for age and sex as a control group. The 2012 Canadian Guidelines criteria were used for the diagnosis of FMS and applied to all Vitiligo patients and controls included in the study. Baseline characteristics of patients with vitiligo and controls were recorded in form of : age, sex, employment condition, and marital status. Body mass index (BMI) was measured for both groups. Patients with vitiligo were fully assessed for : type, duration, severity of disease and medications used.Results : Prevalence of FMS in a sample of Iraqi patients with vitiligo was12% compared to 7% in controls (p=0.15, OR=1.81,95% CI=0.8 - 4.08). FMS symptoms in vitiligo patients were : fatigue 46%, diffuse body pain 34%, sleep disturbance 33%, cognitive dysfunction in 30%, mood disorders 23%, and visceral symptoms : central nervous system (CNS) 52%, skin 35%, gastrointestinal tract (GIT) 32%, cardiovascular system - respiratory system (CVS - RS) 16%, genitourinary tract(GUT) 8%, and ear nose throat (ENT) 7%).There was significant association between the FMS in vitiligo patients and : females with vitiligo 22.2% compared to none among males with vitiligo 0% (P

الخصائص الوبائيه للحروق في مستشفى بغداد للحروق, بغداد, العراق 2015 == Epidemiological Characteristics of BurnInjuries in Baghdad Burn Hospital,Baghdad, Iraq, 2015

اسم المؤلف: رنا خالد الناصر
اسم المشرف: فارس حسن اللامي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الوبائيات التطبيقية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Burns are a global public health problem, accounting for an estimated 265,000 deaths annually, in 2013 fire and heat resulted in 35 million injuries. This resulted in about 2.9 million hospitalizations and 238,000 deaths. This makes it the 4th leading cause of injuries after motor vehicle collisions, falls, and violence. About 90% of burns occur in the developing world. This has been attributed partly to overcrowding and an unsafe cooking situation. Iraq burn injuries are the second cause for visiting emergency room after gun fire according to World Health Organization (WHO) Injury Surveillance Pilot Project, Iraq, 2008.Objectives : To describe epidemiological and clinical characteristics, estimate the case fatality rate and identify the main determinants of death among burn cases in Baghdad Burn hospital, Baghdad, Iraq during 2015.Patients and Methods : A cross sectional study was conducted in Baghdad Burn Hospital. The study population was all the burn cases that were admitted to these hospitals during 2015. The files of the patients were obtained from the statistics department in the hospital. All burn patients with different types and degrees of burn injuries who were admitted to this hospital during 2015 were included in the study. Patients with minor superficial burns treated in the emergency department as out patients and cases that admitted for surgical treatment of old scars were excluded.Data was collected using a form included demographic data, etiology, burn type, anatomical location and percentage of body surface area burned, operating procedures and outcome were recorded.Results : This study involved 676 patients, 32.90% of them were females. 26.62% patients were below 10 years of age. Two thirds had less than 20% of body surface area burns (66.42%) and only 9.46% had more than 50% body surface area burns.Flame burns were the commonest (71.59%) followed by scalds (23.37%) and electrical 2.52%. Scalds were common in children. About 76.33% of patients improved 8.28% left on their responsibility and 2.07% shifted to other hospitals. Case fatality rate was 13.30%, Mortality was 44.4% with sepsis as the leading cause, multiple organ failure, and shock were other causes of mortality.Conclusions : Burns injury is a major public health concern and is associated with high mortality. Flame, scald and electrical burns are commonly a result of domestic and occupation accidents and are preventable. Strict follow up to the infection control guideline can minimize the high case fatality rate.

انتشار اكتناف العين لدى عينة من المرضى العراقيين البالغين المصابين بمتلازمه فرط مرونه المفاصل الحميد == Prevalence of Ocular Involvement in a Sample of Iraqi Adult Patients With Benign Joint Hypermobility Syndrome

اسم المؤلف: ايناس عدنان مجيد
اسم المشرف: محمد هادي العصامي | نجاح كاظم القريشي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: خلفية البحث : تعرف متلازمه فرط مرونه المفاصل الحميد بانها اضطراب النسيج الضام الوراثي الذي يتميز بالام عضليه هيكليه ونطاق المرونه المفرطه في المفاصل , الكثير من مظاهر العين موجوده عند مرضى متلازمه فرط مرونه المفاصل الحميد بعضها مشهورة الترابط مع المرض والاخرى مخبر عنها في تقارير حاله .الهدف : تقييم انتشار وخصائص اكتناف العين لدى عينة من المرضى العراقيين المصابين بمتلازمه فرط مرونه المفاصل الحميد .المرضى والطرائق : شملت الدراسة ( 300) فرد في الدراسه المقطعيه , )100( مريض بمتلازمه فرط المرونه و)200 (من الافراد الاصحاء وهم مطابقين في العمر والجنس للمجموعه التي اخذت كمجموعه تحكم .خضع كل المرضى للفحوصات العينيه والتي تضمنت تقييم حده البصر مع مخطط سنيل , فحص القطعه الاماميه والخلفيه للعين مع مصباح سلت , فحص شيرمر , صبغه الفلورسين القرنيه وتقدير ضغط داخل العين مع مقياس توتر العين بالنفث الهوائي . تم استبعاد المرضى اللذين لديهم رضح سابق في العين اوالمرضى المصابين بفرط ضغط الدم وداء السكري او تراكب مع امراض الانسجة الضامة الاخرى او التهاب المفصل الالتهابي . جمعت بيانات المرضى الديموغرافية والسريرية بما في ذلك العمر والجنس ومعيار كتلة الجسم ,مده الاعراض , بيانات مرتبطه بمظاهر المرض الريئسيه وميزات اخرى مرتبطه بمتلازمه فرط مرونه المفاصل الحميد . تم قياس تقدير مرونه المفاصل بالنسبه الى طريقه درجه بايتون لكل المشتركين في الدراسه .النتائج : من مجموع 100 مريضا مصابا بمتلازمه فرط مرونه المفاصل الحميد ممن التحقوا في هذه الدراسه . تم تحديد انتشار الاخطاء الانكسارية في (%78 (, وحسر)قصر البصر(في (49%) ثم لابوريه (20%) وطول البصرفي (9%) منهم.وجدت المظاهر العينيه الاخرى المحدده جفاف العين في (15%) , بينما التهاب الجفن الامامي والخلفي في (%5) و(4%)من المرضى على التوالي .شخصت متلازمه الصباغ التشتتي في (3 %) واخر المظاهر العينيه المحدده ساد في (2%) من مرضى متلازمه فرط مرونه المفاصل الحميد .ان كل النتائج السابقه ذات دلاله احصائيه ماعدا ساد حيث لم تصل الى حد الدلاله الاحصائيه .لايوجد رابط معتد بين العمر , الجنس , نوع المفصل الاكثر شيوعا ودرجه المفصل في حرز بايتون مع زياده خطر المظاهر العينيه . الاستنتاجات : مظاهر العين في عينة المرضى العراقيين المصابين بمتلازمه فرط مرونه المفاصل الحميد شائعه نسبيا. ان اكتشافات العين المتعلقة بمتلازمه فرط مرونه المفاصل الحميد الاكثر شيوعا هي حسر البصر ثم لابوريه ثم طول البصر .لقد كان جفاف العين , التهاب الجفن الامامي والخلفي ومتلازمه الاصباغ التشتتي وساد قليله الحدوث في متلازمه فرط مرونه المفاصل الحميد . | Background : Benign joint hypermobility syndrome (BJHS) is a hereditary connective tissue disorder, characterized by musculoskeletal pain and an excessive range of motion in joints . Many ocular manifestations of BJHS have been described, some being well - known associations and others reported for the first time in case reports .Objectives : The aim of this study was to evaluate the prevalence andcharacteristics of ocular involvement in a sample of Iraqi patients with BJHS. Patients and methods : A total of 300 individuals were included in this cross sectional study, 100 patients had benign hypermobility syndrome and another 200 healthy individuals matched in age and sex were taken as a control group.All patients undergone for opthalmological examination involved visual acuity assessment with Snellen chart, examination of anterior and posterior eye segments with the slit lamp, Schirmer test and corneal fluorescein staining and assessment of intraocular pressure with air puff tonometer.Patients had history of previous eye trauma, hypertension, diabetes mellitus, and overlap with other connective tissue diseases or inflammatory arthritis were excluded. Demographics and clinical data were collected including age, sex, BMI duration of symptom, data related to main disease manifestations and other related features to BJHS. The assessment of joint mobility was measured according to Beighton score method for all the participants in the study.Results : A total of 100 patients with (BJHS) enrolled in this study. Prevalence of refractive errors detected in 78% patients, myopia was detected in (49%), followed by astigmatism (20%) and hypermetropia (9% ) .The other identified ocular manifestation was dry eye (15%), While anterior & posterior blepharitis (5% and 4%) respectively. Pigment dispersion syndrome diagnosed in (3%) of patients and The last identified ocular manifestation was cataract which detected in about (2%) of BJHS patients.All previous findings were statistically significant except cataract not reach to statistically significant level. There were no significant correlation between age group, gender, type of common joint involved or degree of beighton score with increase risk of ocular manifestations .Conclusions : Ocular manifestations in a sample of Iraqi patients with BJHS were relatively common. The most common BJHS - related ocular findings were Myopia followed by, Astigmatism and hypermetropia. Dry eye symptoms, anterior and posterior blepharitis, pigment dispersion syndrome and cataract are rare in patients with BJHS.

تاثير الارتجاع العضوي المزمن للصمام الاكليلي على وظيفة البطيي الايمن الانبساطية باستخدام دوبلر صدى القلب في عدة مراكز للقلب في بغداد == Impact of chronic organic mitral regurgitation on Right Ventricular Diastolic Function using Doppler echocardiographic study in Multi Cardiac Center in Baghdad

اسم المؤلف: عطاء خليل طه
اسم المشرف: غازي فرحان حاجي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: صدى القلب
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : To date, little is known regarding the effect of left ventricular volume overload on right ventricular diastolic function. We hypothesized that patients with chronic organic mitral regurgitation and preserved left ventricular systolic function might have subclinical right ventricular dysfunction, and related to pulmonary artery systolic pressure.Objective : To study the effect of left ventricular volume overload on right ventricular diastolic function by Doppler echocardiography in patients with chronic organic compensated mitral regurgitation.Patients and methods : A cross - sectional study held in multi cardiac center in Baghdad. From April 2015 to June 2016. Patients categorized in to two groups; Thirty - one were without pulmonary hypertension (group I, mean age 32±7.1 years) and thirty of patients were with pulmonary hypertension (group II, mean age 36.1±5.7years). All of them compared with sixty - one healthy individuals serving as a control group (group III, mean age 32.1±6.6 years). Transthoracic echocardiography (multiple views) M - mode, Two - dimensional and Doppler were done for all groups of study.Results : Conventional and tissue Doppler echocardiographic assessment of right ventricular diastolic function revealed impairment in up to 44.3% of patients, (19.4% in group I vs 70% in group II, P<0.001). Patients had lower right ventricular E - wave velocity, lower E/A ratio, and prolonged right ventricular isovolumic relaxation time compared to control. Tissue Doppler analysis showed lower E', and lower E'/A' ratio. All changes were statistically significant at P < 0.001). Patients with pulmonary hypertension were older with higher E/E' ratio in comparison to the other two groups (5.79±1.75 in group II vs 3.91±0.41, 4.08±0.93 in group III and I, respectively, P <0.001).

التدخين بين الكوادر الطبية والصحية في مستشفيات بغداد 2016 == Smoking among Health Care Workers in Baghdad Hospitals, 2016

اسم المؤلف: ولاء طالب یوسف
اسم المشرف: ايمان عدنان القصير
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الوبائيات التطبيقية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Smoking is the inhalation of the smoke of burning tobacco encased in cigarettes, pipes, shisha or argela and cigars. Smoking causes diminished overall health, increased absenteeism from work, and increased health care utilization and cost. Quitting smoking lowers the risk for smoking - related diseases and can add years to life. The global tobacco epidemic is predicted to kill 10million people annually over the next 20 to 30 years (mainly in developing countries). Health Workers have potential role in preventing smoking among patients as they are health educators and counselors for quitting smoking.Objectives : To determine smoking prevalence among Health Care Workers and to study HCWs knowledge and attitudes toward tobacco smoking during work.Methods : A cross sectional study was conducted on three general hospitals in Baghdad Al Karkh side that were chosen randomly and all Health Care Workers that agree to participate during time of visit to their hospitals were included in the study and they were 448; from end of June to end of August 2016; data collected through self - filled questionnaire then data was entered and analyzed by excel sheet and SPSS software. Results : Mean of age of participants was 35.6±10 years; the prevalence of current smoker was 12.5%; most of particip ates were aware about smoking complications (92%); most of participates expressed positive attitudes towards smoking control irrespective of their own smoking status; about 90% of participates were bothered from Second Hand Smoking; the mean of cigarette smoking was 20±12 cigarettes per day; the mean of 1st age for starting smoking was 21±8 years & the mean of period of smoking was 13.7±8 years. About 39% of smokers had signs of nicotine addiction.Conclusion : The prevalence of smoking was relatively low; males were significantly more prone to smoke (96%) compared to females; there was no significant association between smoking and profession; females were significantly bother from Second Hand Smoking; smokers that get sickness from smoking were more prone to stop smoking and there was significant association between periods of smoking with nicotine addiction.Recommendations : Activation of penalty fines on smoking during work or induce Official penalty & Provision of special places for smoking in work places.

قيمة السلالة الطولية مقابل تصوير الاوعية التاجية في الكشف عن مرض الشريان التاجي == The Value of Longitudinal Strain versus Coronary Angiography in Detection of Coronary Artery Disease

اسم المؤلف: حسان نوري محمود
اسم المشرف: معتز فوزي حسين
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: صدى القلب
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Introduction : Coronary artery disease is characterized by atherosclerosis in the epicardial coronary arteries. The reduction in coronary artery flow may be symptomatic or asymptomatic, occurs with exertion or at rest, and culminate in a myocardial infarction or angina, depending on obstruction severity and the rapidity of development. Speckle - tracking echocardiography is a new noninvasive ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function independently from the angle of insonation and from cardiac translational movements.Aim of the study : to assess the value of longitudinal strain versus coronary angiography in detection of coronary artery disease Patients and method : A cross sectional study was conducted in Ibn - Albitar hospital during the period between March 2015 and March 2016 and a sample of 72 patients was selected with positive coronary angiography. Results : The mean age of patients was 56.4 ± 10.1 years; furthermore, 73.6% of the patients aged more than 50 years. About half of the patients, (51.4%) were smokers, (73.6%) were diabetic, (33.3%) were hypertensive and (58.3%) had hyperlipidemia. the findings of 2D LV Longitudinal strain - speckle tracking, positive LADA (left anterior descending artery) stenosis was reported in (86.1%), the CX artery stenosis reported in (76.4%) and the RCA stenosis was found in (84.7%) of the patients. for the stenosis in LADA, the current study showed that the longitudinal strain was a good predictor with a sensitivity of (93.8%), specificity (75%) and accuracy (91.7%) compared with coronary angiography, with good performance of the test between tests, good predictive value and accuracy of the test.The longitudinal strain showed that there was a good performance in detection of stenosis in CXA with high sensitivity, specificity and accuracy. The performance and validity of 2D LV longitudinal strain in detection of RCA stenosis in comparison with angiography, it had a sensitivity of (93.5%), specificity of (70.0%) and accuracy of (90.3%).Conclusion : The current study revealed that the Speckle - tracking echocardiography technique has a good performance and validity in detection of coronary artery stenosis with very good agreement with angiography.

عوامل الخطورة وتصنيــف اورام الرحــم وتدريجاتـه == Risk factors and histopathological types of uterine cancer 2016

اسم المؤلف: رشا زكــــي شكــــــر
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: سرطان الرحم نسبيا يعتبر من الاورام الشائعه بين النساء حيث انه ياتي في المرتبه الرابعه بين الاورام الخبيثه التي تصيب النساء خاصة النوع الشبيه ببطانة الرحم.ان التصنيف حسب التشريح النسيجي المرضي ومرحلة الورم وعوامل الخطوره للمرض لم يتم تقييمها بصوره جيده في النساء العراقيات من اللواتي اصبن بهذا المرض.الغرض من الدراسةان الغرض من هذه الدراسة هو لمعرفة نوع الورم حسب التشريح النسيجي المرضي ومرحلة المرض عند تشخيص المرض وعوامل الخطوره للمرض بين المريضات العراقيات المرضى وطرق البحثتشمل هذه الدراسة خمسه واربعون مريضة مصابة بسرطان الرحم من مراجعات مستشفى الاورام التعليمي في مدينة الطب في بغداد للفترة من شهر كانون الثاني لغاية شهر نيسان 2016.لقد تم جمع المعلومات الضروريه من خلال الاستبيان المعد مسبقا من قبل فريق البحث وقد تم جمع المعلومات المطلوبه من فايلات المرضى المراجعين لمستشفى الاورام التعليمي في مدينة الطبالنتائجفي هذه الدراسة كانت 77.8% مريضة بعمر اكثر من 50 سنة ,86.7% من المريضات كان لديهن تاريخ احاظه مبكره,86.7% من المريضات كن في مرحلة سن الياس.كانت هناك نسبه قليله من المريضات ممن كان لدين تاريخ دوائي باستخدام الهورمونات او عدم الانجاب او وجود تاريخ مرضي للمرض في العائله وان نسبة 51% كن في المرحله الاولى من المرض اثناء تشخيص المرض ابتدائيا | Uterine cancer is relatively common; it’s the fourth most common malignancy in women. Histopathological types, staging and risk factors for uterine cancer are not yet well evaluated in Iraqi patients with uterine malignancy.Aim of study : - To classify uterine carcinoma patients according to histopathological type, risk factors and stageing.Patients and method : Cross - sectional study was conducted for 45 patients in Oncology Teaching Hospital, Medical city, Baghdad, Iraq between Jan.1st - April 1st2016. The data were collected from the medical records of patients with uterine cancer who’s attending to the hospital for completion of treatment through questionnaire which was developed by research team.Results : - The results of this current study on total of 45 patients showed that 77.8% 35 patients were older than 50 years, 86.7% 39 patients with history of early menarche, 86.7% 39 patients were in post - menopause phase, 33.3% of patients had history of hormonal therapy, infertility and family history of the disease. Endometrioid and Papillary serous types represented the highest percentage (42.2%, 28.9%) respectively. Highest percentages (51%) of patients were in stage one at the time of diagnosis.Recommendation : - - Further studies on uterine tumor. - Early detection programs should be activated. - Close follow up on patients from Stage 1. - Awareness programs on risk factors should be activated. - Patients educational sessions should be conducted regularly in the Hospitals.

معالجة اورام الدماغ في العراق 2016 == Management of brain Tumors in Iraq 2016

اسم المؤلف: هدير رياض سعيد
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: CNS tumors constitute 2% of all cancers, and are observed in 4 - 5 in 100,000. CNS tumors exhibit different behaviors according to age, histology, and location.Aim of study1 - Detect the rate of incidence of CNS tumors in relation to age, sex, geographical distribution, environmental factors & genetic factors in our country2 - Explaining of the associated clinical features3 - Determine the effect of radiotherapy & chemotherapy on the patient’s outcome.Patients and methodsProspective study of CNS tumors started from the beginning of Jan 2016 to the end of Apr 2016. The patients were taken from the outpatient clinic of Oncology Teaching Hospital / Medical City in BaghdadAll patients (47) underwent surgery and the surgeons then sent them to our out patients clinic with their Histopathological reports seeking for further management.(42) Patients received Chemotherapy and/or Radiotherapy while the remaining (5) patients didn’t followed up after surgery because they didn’t attend to our out patients clinic according to their dates.The outcome of management was divided into : Good outcome, Fair outcome and Poor outcome.ResultsThe 5th decade is the most commonly involved age with male incidence more than females and the incidence is higher in the south of Iraq. There is little IIassociation of CNS tumors with family history and high association with environmental factors. Neurological deficit was the main chief compliant and headache was present in most of the patients at time of diagnosis. Frontal region was the commonest site for CNS tumors with size of 1 - 5cm and mostly associated with edema and +ve enhancement. Meningioma was the commonest histological type.Conclusions1 - There is a poor relationship between family history & CNS tumors2 - There is significant relationship between environmental factors & CNS tumors.3 - Headache is not the dominant chief compliant in compare with neurological deficit .4 - Total resection of the tumor followed by radio and/or chemotherapy has the best prognosis.Recommendations1 - Further researches with larger sample size to be collected from all oncology hospitals in Iraq are needed to generalize the results to national level .2 - Make the total resection of the brain tumor the aim of the surgeon because it is the golden stone in brain tumor management.3 - Use the new technique of radiotherapy like gamma knife and IMRT for the

التقييم الكهروفسلجي للانواع الفرعيه لمتلازمة غوليان - باريه لشريحه من الاطفال العراقيين == ELECTROPHYSIOLOGICAL ASSESSMENT OF GUILLAIN - BARRE SUBTYPES IN A SAMPLE OF IRAQI CHILDREN

اسم المؤلف: لميس منصور حسين
اسم المشرف: نجيب حسن محمد
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة العصبية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Guillain - Barre syndrome represents the most common cause of acute motor paralysis in children. It is clinically characterized by an acute non - febrile, post - infectious illness marked as ascending weakness, and areflexia. However; sensory, autonomic and brainstem abnormalities may also be seen.This study aimed to assess the role of electrophysiological study (NCS and EMG) in the diagnosis of Guillain - Barre syndrome subtypes in children, estimate the frequency of subtypes whether demyelinating or axonal form of Guillain - Barre syndrome and match the electrophysiological results with the findings of CSF protein analysis.Two groups of either sex are involved in this study, children with Guillain - Barre (19 males and 11 females) with a mean age of (5 ± 2) years and normal healthy children served as control group (16 males and 14 females) matched for gender and age with a mean age of (6 ± 3) years. Each child submitted to medical history, brief clinical examination, and electrophysiological study. This study was performed at the unit of neurophysiology of Baghdad teaching hospital and Nursing house hospital in a period from December/2015 to June/2016.The electrophysiological assessments involve the following tests : 1 - Sensory NCS for bilateral median, right ulnar and bilateral medial plantar nerves in which latency, sensory nerve action potential amplitude (SNAP) and sensory nerve conduction velocity (SNCV) were studied.2 - Motor NCS for bilateral median, right ulnar and bilateral common peroneal nerves (fibular nerve) in which, distal motor latency (DML),compound muscle action potential amplitude (CMAP), motor nerve onduction velocity (MNCV), conduction block and temporal dispersio were performed.3 - Minimal F - wave latency for bilateral median, right ulnar and bilateral fibular nerves.4 - H - reflex latency of bilateral tibial nerve.5 - Needle EMG for bilateral proximal and distal muscles of upper (first dorsal interosseous) and lower limbs (tibialis anterior and extensor digitorum brevis) in which insertional activity, spontaneous activity, motor unit action potential MUAP and interference pattern were applied.The results of this study revealed that acute inflammatory demyelinating polyneuropathy (AIDP) is the most frequent subtype followed by acute motor axonal neuropathy (AMAN) and acute motor sensory axonal neuropathy (AMSAN) respectively. Children with an age (3 - 6) years among other age groups are more vulnerable to develop GBS following infection in the preceding 3 months.The sensory nerve parameters (sensory latency is prolonged, SNAP is reduced and SNCV is slowed) are significantly changed between GBS children and control groups.The motor nerve parameters (DML is prolonged, CMAP is reduced and MNCV is slowed) are significantly changed between GBS children and control groups. Moreover among the GBS subtypes, there were significant differences in which the prolonged (DML) mostly in AIDP subtype, while the reduced (CMAP) mostly in axonal subtype was reported.Concerning minimal F - wave, it was absent in lower limbs more than upper limbs (46.6% and 26.6% respectively). Whereas H - reflex was absent in (73.3%) of children.Needle EMG had showed reduced recruitment in all GBS subtypes in addition to the evidence of spontaneous activity particularly in axonal subtype.In conclusion, this study detected that the AIDP was the most frequent subtype of GBS compared to others. Motor nerve conduction study is more useful than sensory nerve conduction study in GBS subtyping.Additionally Late responses (minimal F - wave and H - reflex) are very informative in the early course of the disease since they reflect the involvement of proximal nerve segment, which is more vulnerable to demyelination than terminal and intermediate nerve trunk segments, in addition CSF protein analysis showed no significant differences between GBS subtypes.

تاثيرات الامراض المتزامنة على فاعلية المرض والحالة الوظيفية للمرضى المصابين بالتهاب الفقار المقسط == Comorbidities Effects on Disease Activity and Functional Status in Patients with Ankylosing Spondylitis

اسم المؤلف: غسان مكي كاظم
اسم المشرف: نزار عبد اللطيف جاسم
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Ankylosing spondylitis is a chronic, multisystem inflammatory disorder that primarily involving the sacroiliac joints and the axial skeleton and less frequently the peripheral joints, entheses as well as other extra - articular organs such as eyes, skin, and cardiovascular system.Patients with ankylosing spondylitis frequently suffer from comorbidities that may either be linked to the disease process, to the treatment, or may be an independent finding and they contribute to the burden of the disease.Objective : To evaluate the relative frequency of comorbidities in ankylosing spondylitis and their effects on disease activity and functional status. Patients and methods : A longitudinal study was conducted on (402) ankylosing spondylitis patients. Patients who had irregular registration were excluded.Demographic and clinical data were collected including age, sex, duration of disease, previous and current treatment, Bath Ankylosing Spondylitis Disease Activity Index score (BASDAI) and Bath Ankylosing Spondylitis Functional Index score (BASFI) were applied to all patients. All patients were asked to confirm the presence of any of five comorbidities which were hypertension, diabetes mellitus, peptic ulcer, heart failure and cerebrovascular accident, then presence of many of these comorbidities were confirmed by data from patient’s medical reports or physician prescriptions.Results : The most frequently reported comorbidity in the current study sample was hypertension(20.1%), Peptic ulcer is (17.2%), diabetes mellitus is (9.5%), heart failure and cerebrovascularVIaccident were very rare, accounting both for (2%) of all cases. At least one of these comorbidconditions was present in (30.6%) of cases.Presence of hypertension was associated with significant increase in BASDAI and BASFI at baseline. Additionally it was found that presence of any comorbid condition or multiple comorbidities was associated with higher mean BASDAI and BASFI. Presence of the remaining comorbidities had no significant differences.Hypertension is associated with a significantly higher mean reduction in BASDAI score after six months of biological treatment compared to those with no hypertension. Similarly the presence of any comorbid condition or multiple comorbid conditions are associated with significant mean reduction in BASDAI score after six months, The remaining comorbid conditions had no significant association with the mean change in BASDAI score.None of the tested comorbid conditions had an important or statistically significant association with the mean change in BASFI score after six months. Conclusions : Comorbidities are relatively frequent in ankylosing spondylitis and hypertension is the most common comorbid condition. Multiple comorbid conditions or hypertension with ankylosing spondylitis are associated with more active disease and functional impairment.

دراسة فاعلية وسلامة التغييرات المختبرية ومعلمات التنبؤ للاستجابة لعقار الاداليموماب في علاج المرضى المصابين بالتهاب الفقار المقسط النشط == Efficacy, Safety of Laboratory Changes and Predictors of Response to Adalimumab in Treatment of Patients with Active Ankylosing Spondylitis

اسم المؤلف: ليث محمود شاكر
اسم المشرف: خضير زغير معيوف البدري
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Ankylosing Spondylitis belongs to a family of rheumatic diseases known as spondyloarthritides that characteristically cause spinal joint inflammation and bony fusion of the spine. Ankylosing spondylitis is the prototype of the Spondyloarthritides and is typified by ankylosis of the axial skeleton.There is no cure for ankylosing spondylitis, although treatments and medications are available to reduce joints pain and stiffness with subsequent improvement in quality of life.Adalimumab is a fully human monoclonal antibody of the Immunoglobulin G1isotype that neutralizes the biological function of tumor necrosis factor - α, has been used as effective treatment in ankylosing spondylitis in the last years.Objective : To assess the efficacy and safety of laboratory changes of Adalimumab in treatment of patients with active ankylosing spondylitis, as well as to assess the predictors of response to Adalimumab in treatment of patients with active ankylosing spondylitis.Patients and methods : An open labeled single group prospective study that was conducted over 17 months period on 61 Iraqi patients with ankylosing spondylitis diagnosed according to Modified New York criteria (1984) for diagnosis of ankylosing spondylitis and ASAS classification criteria for axial SpA .All the patients included in the study were given Adalimumab vial at a dose of 40 mg by subcutaneous injection every other week. Each patient was followed at regular intervals of baseline, 3 months and 6 months for disease activity including Bath Ankylosing Spondylitis Disease Activity Index and functional assessment including Bath Ankylosing Spondylitis Functional Index and for laboratory changes in hemoglobin, white blood cell count, aspartate aminotransferase, alanine aminotransferase, blood urea and serum creatinine . In addition, the study assessed eight different patients’ characteristics : age, gender, disease duration, human leukocyte antigensubtype B27, smoking, using steroids, using disease - modifying antirheumatic drugs (methotrexate, sulfasalazine), and drug history of using of other biological drugs (Etanercept, Infliximab) as predictors of response to Adalimumab treatment.Results : Data analysis showed that Bath Ankylosing Spondylitis Disease Activity Index 50% response rate was 59% after three month of treatment and reached to 85.6% after six months of treatment, the analysis also showed that the age and a positive history of using other biologic agents as apart from ( gender, disease duration, human leukocyte antigensubtype B27, smoking status , using steroids, and disease - modifying anti rheumatic drugs ) had a statistically significant association with reduced response to treatment, for each one year increase in age, the risk of being a respondent is decreased by 4% (P=0.026), and a positive history of using biologic agents is associated with decrease in the risk of being a respondent by 2.5 times (P=0.016) , all the variables were statistically significant effect on treatment and were evaluated as a strong effect (Cohen’s d>0.8). In Bath Ankylosing Spondylitis Functional Index ≥5 group, data analysis showed that their is statistically significant reduction by a mean of 2 units after three months of treatment and reached to a mean of 2.5 units after six months of treatment, the data analysis showed that increase age and a positive human leukocyte antigen - subtype B27 had a statistically significant association with reduced response to treatment, all the variables were statistically significant effects on treatment and were evaluated as a strong effect (Cohen’s d>0.8).In Bath Ankylosing Spondylitis Functional Index ˂5 group, data analysis showed that their is statistically insignificant reduction in the score of by a mean of 0.5 units after three months, and 0.6 units after six months of treatment, all the variables were statistically insignificant effects on treatment and were evaluated as a weak to moderate effect.The treatment effect of Adalimumab was evaluated as a moderately strong reduction in white blood cell count (Cohen’s d=0.43). While treatment effect on (hemoglobin, aspartate aminotransferase, alanine aminotransferase, blood urea and serum creatinine) was evaluated as week effects (Cohen’s d<0.3).Conclusion : Adalimumab drug is effective and relatively safe in treatment of patients with active ankylosing spondylitis. Increase in age, positive history of using of other biological drugs (Etanercept, Infliximab) and positive human leukocyte antigen - subtype B27 had significant correlation with reduced response to treatment.

جدوى قياس سرعة الانتشار في الشريان الابهر النازل كمعيار تنبؤي لامراض الشرايين التاجيه في اثنين من مراكز القلب في بغداد == The Value of Measuring Propagation Velocity Of The Descending Aorta as Predictor of Coronary Artery Disease in Two Cardiac Centers in Baghdad

اسم المؤلف: دنيا حامد كاظم
اسم المشرف: امال نوري المراياتي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: صدى القلب
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Elastic properties of the aorta affect the left ventricular function and epicardial arteries blood flow. Thats why several parameters are used to assess those properties in order to predict the likelihood of atherosclerotic coronary artery disease. Those parameters include aortic strain, aortic distensibility and early diastolic velocity of the anterior aortic wall.Objectives : Testing the value of aortic propagation velocity as a parameter of aortic stiffness in predicting coronary artery disease. The strength of this parameter in predicting the number of affected coronary arteries is also assessed.st of August 2015 to the 1 st Study population and methodology : From the 1 of July 2016, and after applying the inclusion and exclusion criteria, 120 patients were included in this comparative multi - center study. They were assessed for demographic criteria and risk factor profiles. Trans thoracic echocardiographic examination was done, all the needed measurements were obtained as well as measuring the carotid intima media thickness by Doppler, then the results of their coronary angiography were revised, 60 patients were included in the coronary artery disease group and another 60 in the non - coronary artery disease group.Results : Aortic propagation velocity was found to be related to the aortic distensibility, strain, early diastolic anterior aortic wall velocity and the overall carotid intima media thickness to a statistically significant level (r=+0.481, p<0.001; r=+0.548, p<0.001; r=+0.595, p<0.001; r= - 0.361, p<o.oo1 respectively). It was found that aortic propagation velocity predicts coronary artery disease (p<0.001) and correlates with the number of affected coronary arteries (r= - 0.711, p<0.001).Conclusion : Aortic propagation velocity is an easily applied echocardiographic parameter of aortic stiffness that can predict coronary artery disease caused by vascular atherosclerosis in a non - invasive way. It also correlates with the number of the affected coronary arteries.

معرفة ومواقف النساء الحوامل حول طرق الولادة == Knowledge and Attitudes of Pregnant Women towards mode of Delivery In Baghdad Teaching Hospital - 2016

اسم المؤلف: هند عامر ناهي الخفاجي
اسم المشرف: نادية عزيز ناصر
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب العائلة
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Delivery is one of the most important issues for human being and generation in the world. The process through which childbirth naturally occurs is called natural vaginal delivery. Caesarean is delivery of child through incisions in abdominal wall (Laparotomy) or uterus (Histrotomy).Aim of the study : To assess the knowledge, attitude of pregnant women and the associated factors with attitude towards the mode of delivery.Patients and method : A cross sectional study conducted in prenatal clinic in Baghdad teaching hospital for four months duration from the 1st of Feb. 2016 to the end of the May 2016.Results : A total of 300 pregnant women were included in present study with mean age as 28.3±9.8 years; Most of studied women were housewives. More than half of pregnant women (54.3%) married at younger age. The information of pregnant women about delivery modes were obtained mainly from social relationships (82.6). Half of pregnant women had good knowledge of delivery modes, 90.3% of them had good attitude toward normal vaginal delivery, 51.3% of them had poor attitude toward cesarean section .A significant association was observed between older age women and poor knowledge of them regarding delivery modes (p=0.01). There was a significant association between employed women and good knowledge score.Conclusion : The knowledge of pregnant women regarding vaginal delivery was relatively low and the attitude was high, while their attitude toward cesarean section was low. The main associated factors for women's knowledge were women's age, job, educational level, husband's age and abortion history and the main factors for women's attitude were women's age, educational level of women and their husbands and history of previous cesarean section.

دراسة مقارنة بين الرياضيين وكثيري الجلوس من ناحية وظائف الرئة وتشبع الاوكسجين وتركيز الشوارد في الدم == Comparative Study of Pulmonary Functions, Oxygen Saturation, and Electrolytes in Athletes and Sedentary Controls at Rest

اسم المؤلف: زياد طارق عبد الرزاق
اسم المشرف: زيد عبد المجيد المدفعي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: علم وظائف الاعضاء الرياضية هو دراسة الاثار طويلة المدى وقصيرة المدى للتدريب والظروف على الرياضيين، لمعرفة كيف يتفاعل رياضيا لانواع معينة من التمارين الرياضية.العضلات، والشوارد وتشبع الاكسجين تتاثر في الغالب في ممارسة. وفقا لنوع من الرياضة، ومدة التدريب والعضلات تتاثر في الغالب من قبل هذا التمرين، تتاثر قراءات الرئوية ايضا، وتميل الى ان تكون اعلى لدى الرياضيين من تلك التي من الناس المستقرة وبين المجموعات الرياضية انفسهم.1. هذه الدراسة وسط لتحديد احتراما في استجابة لاختبار وظائف الرئة، الشوارد وتشبع الاكسجين بين الرياضيين والمستقرة.2. التعرف على الفروق في استجابة لاختبار اداء الرئتين، وتشبع الاكسجين والشوارد بين الرياضيين من مختلف الرياضة الاكثر شعبية في العراق.اجريت قياس التنفس، ومستوى تشبع الاكسجين والدم الشوارد بما في ذلك الكالسيوم والمغنيسيوم والصوديوم والبوتاسيوم على 66 الرياضيين المستوى الوطني مختلفة تتراوح اعمارهم بين [24.36 ± 4.65 سنة]. وكان لاعب من خمس مجموعات رياضة مختلفة وكانوا جميعا من الذكور. للخروج منها، كان هناك 20 المصارعين، 15 لاعبي كرة القدم، 8 سباحين و8 عدائين و15 الكاراتيه مختلطة المقاتلين جميعهم رجال الرياضية المتخصصة، في حين كانت المستقرة 40 طلاب الطب، والذكور. وتبين هذه الدراسة ان الرياضيين لديها اعلى اختبارات وظائف الرئة من الجلوس في حين اظهر تشبع الاكسجين والشوارد في الدم في هذه الدراسة لا يوجد فرق كبير بين الرياضيين في الراحة وتلمس المستقرة | Sports physiology is the study of the long - and short - term effects of training and conditions on athletes, to learn how an athlete reacts to specific types of exercise.Muscles, electrolytes and oxygen saturation are mostly affected in exercise; and according to the type of sport, duration of training and muscles mostly affected by this workout, pulmonary readings are also affected and tend to be higher in athletes than those of sedentary people and between athletic groups themselves.1. This study is amid to Identify the deference in response of pulmonary function test, electrolytes and oxygen saturation between athletes and sedentary.2. Identify the differences in response of pulmonary function test, oxygen saturation and electrolytes between athletes of different most popular sport in Iraq.Spirometry, oxygen saturation level and serum electrolytes including calcium, magnesium, sodium and potassium were conducted on 66 different national level athletes aged [24.36 ± 4.65 years]. The athletes were from five different sport groups and were all males. Out of them, there were 20 wrestlers, 15 footballers, 8 swimmers, 8 runners and 15 karate mixed fighters all of them are specialized sports men, while sedentary were 40 medical students, males. This study shows that athletes have higher pulmonary function tests than sedentary while oxygen saturation and serum electrolytes in the present study showed

المعرفة والمواقف حول اجهزة منع الحمل داخل الرحم بين عينة من النساء في بغداد == KNOWLEDGE AND ATTITUDE CONCERNING INTRAUTERINE CONTRACEPTIVE DEVICE AMONG A SAMPLE OF WOMEN IN BAGHDAD

اسم المؤلف: ميرفت عبد علي عبد الوهاب
اسم المشرف: بتول علي غالب ياسين
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب العائلة
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Although intrauterine contraceptive device (IUCD) is the most widely used of long acting reversible method of fertility regulation in the world today, only 10% of Iraqi women aged 15 to 44 were using IUCD in 2011..Objective : To assess the knowledge and attitude towards intrauterine contraceptive device among women in reproductive age in Baghdad city, and to identify the effect of certain factors on their knowledge and attitude.Methods : A cross sectional study was conducted in Baghdad Teaching Hospital and Al - Shaheed Abdul - Sahib Dakhil PHCC. Any woman aged (15 - 45 years) who agreed to participate was included in the study. Data was collected through direct interview with the participants and the scores of knowledge were classified into : Good, fair and poor for knowledge and positive, neutral and negative for attitude.Results : Assessing the knowledge and attitude of the 301 participants revealed that 97.3% knew what IUCD is and 96.6% were aware of the aim of using the Copper IUCD, 42.8% were aware of its side effects, whereas only 5.9% of them were aware of the types, 13.9% aware of complications and 3.3% aware of who is eligible for using IUCD. In spite of this only 1.0 % of the participants got good knowledge score and 76.1 % got poor scores. Regarding attitude 15.0% had a positive attitude toward the use of IUCD.Knowledge scores of the respondents increased with increasing age (p<0.001), level of education (P = 0.026), being married (P=0.008),number of children (P<0.001) and history of previous abortions (P=0.04). Friends, neighbors and relatives were the main source of knowledge (77.4 %(.Conclusions : Most of participants were with poor knowledge score and the main source of them were friends, neighbors and relatives.Attitude score of Less than one - fifth of them was positive

انواع الرضاعة والاستجابة للعلاج الضوئي كعلاج للاطفال حديثي الولادة المصابين بمرض اليرقان الغير مباشر في المستشفيات التعليمية في بغداد == Types of Infant Feeding and Response to Phototherapy as a Treatment for Fullterm Newborns with Neonatal Indirect Hyperbilirubinemia in Tertiary Teaching Hospitals in Baghdad

اسم المؤلف: شيماء خضير عباس
اسم المشرف: احمد سمير النعيمي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب العائلة
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Neonatal jaundice remains the most common and the most controversial problem in full - term newborns during the immediate postnatal period.Aim of the study : To assess the association between types of feeding and response to phototherapy in full - term infants with indirect hyperbilirubinemia.Method : In the period from the 25th of January to the 22th of July 2016, 120 full - term newborns admitted to the neonatal care unit in Tertiary Teaching Hospitals (Pediatric Teaching Hospital in medical city, AI - Imamein Al - Kadhimein medical city and Child Center Teaching Hospital) were studied by cohort study. The newborns diagnosed by pediatrician as cases of indirect hyperbilirubinemia and phototherapy started when TSB level>14.9 mg/dl. TSB was measured twice daily and phototherapy terminated when TSB level< 10.8 mg/dl. All infants were weighed at start and end of phototherapy. The duration of phototherapy had been recorded.Results : The infants divided into three groups according to type of feeding; group1, Breast - fed infants (n=37); group2, Formula - fed infants (n=51); group3, Mixed - fed infants (n=32).Phototherapy was highly effective in reducing serum bilirubin concentration in all of three groups but with a significant less efficacy for breast - fed neonates ( mean duration of phototherapy 32.2± 2.1 hrs) in comparison to mix - fed neonates (30.4 ± 2.5 hrs) and formula - fed neonates (29.9± 2.7 hrs).There was a weight loss during phototherapy. There was significant difference in the weight loss in the three groups, the more weight loss in breast - fed neonates than mixed - fed and formula - fed neonates. Conclusion and recommendations : Phototherapy had effectively reduced bilirubin levels in breast - fed newborns with hyperbilirubinemia, but these patients showed a significantly slower response to this modality of treatment than mixed and formula - fed newborns. Therefore; in breast - fed infants with severe jaundice that requires phototherapy, the addition of formula - feeding will enhance the response to phototherapy without any interruption of breastfeeding.

كثافة معدن العظم لدى عينة من المرضى العراقيين المصابين بمرض التصلب المجموعي == Bone Mineral Density in a Sample of Iraqi Patients with Systemic Sclerosis

اسم المؤلف: حسين جفات هايت
اسم المشرف: محمد هادي العصامي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Back ground : Systemic sclerosis is a chronic connective tissue disease.Low bone mineral density may be one of the complications that occur inpatients with this disease due to disease chronicity and the presence ofmultiple secondary risk factors for osteoporosis.Objective : to evaluate the bone mineral density (BMD) in patients withsystemic sclerosis and to determine associated risk factors.Methods : In this case - control study, a 37 patients with systemic sclerosisand 61 ages - and sex - matched healthy controls were included. Allpatients had to fulfill the American College of Rheumatology criteria1980 or the American College of Rheumatology/European LeagueAgainst Rheumatism for the classification of systemic sclerosis 2013 toestablish the diagnosis. Exclusion criteria include any other chronic orconnective tissue diseases, all patients who have been on steroids,medications for treating osteoporosis, or other therapies that couldinfluence bone metabolism.Clinical examination was carried out to determine the diseasesubtypes according to skin involvement (limited and diffuse SSc), andpatients were assessed clinically and functionally with Health AssessmentQuestionnaire - Disability Index (HAQ - DI). BMD was measured atlumbar spine (L1 - L4) and the femoral neck .The measurement wasperformed using the dual energy X - ray absorptiometry (DXA) machine(Stratus). The results expressed in gm/cm2, and then compared accordingto age, and body mass index (BMI), disease duration, disease subtype(limited and diffuse) and to menopausal state.Results : The mean age of cases and controls was 37.5 ±9.4 and 38.2 ±7.4years old respectively, small proportion of males in patients and controlgroups (10.8% and 16.4% respectively),20 patients (54.1%) had limitedVIItype and 17 patients had diffuse type, 24.3% of cases with long diseaseduration (> 10 years) while18.9% with a short duration (<5years) and themajority 56.8% within 5 - 10 years. Osteoporosis was detected assignificant in lumbar spine (p=0.003) and in femoral neck (P = ˂ 0.001)with the T - score, also with Z - score was (P =0.007 and P =0.004respectively). Factors such as disability and severity of organinvolvement (HAQ - DI), age, menopausal status and BMI showcorrelation with BMD value, but the correlation did not reach astatistically significant level. No important or statistically significantassociation between BMD and the disease patterns, or treatment used(cyclophosphamide, mycophenilate and azathioprine).Conclusions : the BMD of the femoral neck and lumbar spine wassignificantly lower in patients with systemic sclerosis than in the healthycontrol.

قيمة تتبع للرقطي الطولي في الكشف عن الخلل الانقباضي للبطين الايسر لمرضى ارتفاع ضغط الدم مع مقياس الجزء الانقباضي الطبيعي == The Value of Speckle - Tracking Strain Echocardiography For Detection of Subclinical Left Ventricle Systolic Dysfunction In Hypertensive Patients With Normal Ejection Fraction

اسم المؤلف: بان صباح نوري
اسم المشرف: حسن علي الفرحان
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: صدى القلب
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Hypertension is one of the most common diseases in the world and can cause many structural and functional cardiac abnormalities. One of these changes is left ventricular systolic dysfunction which may not be detected by conventional echocardiographic parameters and need to use a new modality of two dimensional speckle tracking strain for early detection and improvement of prognosis Objectives : Assessment of left ventricle systolic function in hypertensive patients with normal ejection fraction using two dimensional speckle - tracking stain and its role as early predictor of subclinical dysfunction Patients and methods : This was a comparative observational study of two groups of individuals : (100)hypertensive patients and (50) normotensive subjects were enrolled in the study which take place at Ibn Al - Bittar Teaching Hospital from September 2015 to August 2016. Both the conventional echocardiographic parameters (ejection fraction, left ventricular mass and relative wall thickness, diastolic function and mitral annular plane systolic excursion) and speckle tacking longitudinal strain done for the patients. Results : Hypertensive patients with mean age (53.6 ± 5.37), males were (56%) and females were (44%),two dimensional speckle strain showed no significant differences between normotensive ( - 21.1 ± 2.5%) and hypertensive ( - 19.2 ± 3.9%) groups.Applying Cut off value of ( - 17.5%), it was found that 21% of hypertensive patient were present with undetected left ventricular systolic dysfunction even with preserved ejection fraction Global longitudinal strain was reduced significantly in those with concentric left ventricle hypertrophy ( - 18.2 ± 3.5%, p value=0.02),elevated in left ventricular end diastolic pressure ( - 14.8 ± 1.6% , p - value= 0.002) and reduced mitral annular plane systolic excursion ( - 14.8 ± 1.6%, p - value=0.008) Conclusion : Speckle tracking stain is a useful tool in the early detection of subtle left ventricular systolic dysfunction in a group of hypertensive patients with preserved ejection fraction and in whom more aggressive interventions could have a significant impact on prognosis.

كفاءة استعمال الشريط العلاجي لعلاج الفصال العظمي في مفصل الركبة دراسة عشوائية مسيطر عليها == Efficacy of Knee Tape in Management of Knee Osteoarthritis : Randomized Controlled Trail

اسم المؤلف: رشا كاظم حسوني
اسم المشرف: سامي سلمان شهاب
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الفصال العظمي هو اضطراب تنكسي مزمن متعدد الاسباب ، يمتاز باضمحلال الغضروف المفصلي. الفصال العظمي هو سبب رئيسي للالم والاعاقه عند كبار السن على نطاق عالمي . في غضون ذلك تم احراز تقدم محدود باتجاه علاج المرض,معالجة الاعراض هو الركن الاساسي في العلاج. من المهم توفيرعلاجات بسيطه وغير مكلفه التي تزيد من تشكيلة الخيارات للمرضى.الهدف : لفحص تاثير استخدام الشريط العلاجي للركبه في تحسين الالم ، والوظيفة البدنية في مرضى الفصال العظمي للركبة وان الفائده تستمر حتى بعد ايقاف العلاج.المرضى والطرق : الدراسة هي عشوائية متحكم بها, شملت 170 مريضا والذين يعانون مرض فصال الركبة الاولي حسب الكلية الامريكية لامراض المفاصل.تم توزيعهم عشوائيا على ثلاثة مجاميع .تلقت المجموعة الاولى الشريط العلاجي , وتلقت المجموعة الثانية الشريط المتحكم به,وجموعة بدون شريط. كان المقياس لمدى الفعالية للعلاج هو التغير الحاصل في مؤشر فصال العظام لجامعات ماكماستر واونتاريو الغربية (وماك ) (WOMAC ) شاملا الالم، التيبس والوظيفة البدنية.النتائج : وجدت الدراسة ان هناك انخفاضا واضحا ذو دلالة احصائيه في مؤشر الالم ,التيبس ,الوظيفة البدنية عند الزيارة الثانية (3اسابيع من النظام العلاجي) في مجموعة الشريط العلاجي والشريط المتحكم به هو اكبر مما هو بالنسبه لمجوعه بدون شريط.لوحظ عند الزيارة الثالثة بعد مرور 3 اسابيع على قطع العلاج ان مؤشرات الالم ،التيبس ، الوظيفة بقيت تقريبا مقاربه للزياره الثانيه لدى مرضى المجموعة الاولى بينما كان النقصان طفيف في المجموعة الثانية .الفائده للشريط امتدت لثلاثة اسابيع بعد توقف العلاج. الاستنتاجات : الشريط العلاجي كانت طريقه فعالة في تحسين الاعراض لدى مرضى الفصال العظمي لمفصل الركبة فيما يتعلق بالالم، التيبس | Osteoarthritis (OA) is a chronic degenerative disease of multifactorial etiology described by loss of articular cartilage. Osteoarthritis is a leading cause of pain and disability in elderly people worldwide. Meanwhile limited progress has been made towards curing the disease, management of symptoms is the mainstay of treatment. Simple, inexpensive treatments that increase the range of options for patients with the disease are necessary.Aim of the studyTo test the suggestions that therapeutic taping of the knee improves pain and disability in patients with osteoarthritis of the knee and that benefits remain after stopping treatment.Patients and methodsA randomized, control study included 170 patients were diagnosed to have knee OA according to the American College of Rheumatology (ACR) criteria for classification of (KOA).Patients were randomly allocated to receive e either therapeutic tape, control tape, or no tape. The efficacy outcome measure was the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) including the pain, stiffness and physical function subscales.ResultsSignificant reduction in the pain, stiffness , physical function in the 2nd visit (after 3 weeks of treatment regimen) (P<0.001) in tape group and control group (p=0.003) than no tape group (p=0.056).At the third visit 3weeks after cessation of treatment these scores remain to approximate the 2nd visit value in tape group , while slightly decreased in control group. Benefits of therapeutic tape were maintained three weeks after stopping treatment.ConclusionTherapeutic knee taping is an efficacious treatment for the management of pain and disability in patients with knee osteoarthritis

دراسة فاعلية وسلامة ومعلمات التنبؤ للاستجابة لعقار الريتوكسيماب في علاج المرضى العراقيين المصابين بالتهاب المفاصل الروماتويدي النشط == Efficacy, Safety and Predictors of Response To Rituximab in Treatment of Iraqi Patients With Active Rheumatoid Arthritis

اسم المؤلف: سارة طارق عبد العزيز
اسم المشرف: سامي سلمان شهاب
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض - المفاصل
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: دراسة فاعلية وسلامة ومعلمات التنبؤ للاستجابة لعقار الريتوكسيماب في المرضى العراقيين المصابين بالتهاب المفاصل الروماتويدي النشططريقة البحثتمت دراسة 65 مريضا عراقيا خلال فترة 12 شهرا وتم استخدام طريقة معايير الكلية الامريكية لامراض الروماتزم لتصنيف التهاب المفاصل الروماتويدي النشط لتشخيص المرض ACR. اعطي كل المرضى 4 جرعات ريتوكسيماب في الوريد على مدى 6 اشهر 1غرام/ الجرعة. وتمت متابعة كل مريض في كل زيارة لتقييم نشاط المرض بما في ذلك مؤشر الامراض السريرية اخر (CDAI) والدرجة الوظيفية(FC). كما تم تقييم 9 من الخصائص المختلفة للمرضى (العمر، الجنس، مدة المرض، ووجود عامل الروماتويد، ووجود ACPA، حالة التدخين، واستخدام السابق لblocker TNF ، واستخدام الميثوتريكسيت ومؤشر كتلة الجسم) كعلامات تنبئ محتملة لاستجابتهم لعقار الريتوكسيماب.النتائج : واظهر تحليل البيانات تحسنا ملحوظا في نشاط المرض CDAI) (P = 0.005))والعجز الوظيفي (P = 0.001)، ومستوى الهيموغلوبين (p=0.005) وESR p=0.005)) مع استخدام ريتوكسيماب اكثر من 6 اشهر. واظهر التحليل ايضا ان التدخين له علاقة سلبية مع الاستجابة للعلاج (p=0.005). واعتبر استجابة افضل في مجموعة المرضى الحاملين للعامل الرماتويدي في الدم.و كانت المتغيرات الاخرى ليس لها اثار على الاستجابة للعلاج.مجموعة المرضى الذين تحولوا من TNF - blocker للريتوكسيماب كانت (29)، وكانت مجموعة المرضى الذين بداؤ علاج الريتوكسيماب (36) (اما بسبب وجود التدرن لديهم(موجب للPPD ) او عدم توفر العلاجات البايولوجية الاخرى. وتظهر النتائج نفس فاعلية الريتوكسيماب في كلا المجموعتين (P> 0.05).الاستنتاج : 1.الريتوكسيماب علاج فعال سواء سريريا، وظيفيا ومختبريا وامن في علاج المرضى الذين يعانون من التهاب المفاصل الروماتويدي النشط. 2.التدخين له علاقة سلبية مع الاستجابة للعلاج.3. الاستجابة افضل في مجموعة المرضى ذووي العامل الروماتويدي الموجب في الدم. | Rheumatoid arthritis (RA) is a chronic, systemic disease that primarily targets the synovium, leading to synovial inflammation and proliferation, loss of articular cartilage, and erosion of juxtarticular bone. The natural history of the disease is one of progressive joint damage and deformity and, in a minority, the development of extra - articular manifestations, and premature death. RA follows a disease course of remissions and exacerbations. Rituximab (RTX) is an anti - CD20 chimeric monoclonal antibody which effectively deplete B cells and is used for treating rheumatoid arthritis.Objectives Aim of the study is to assess the efficacy and safety of rituximab (RTX) in Iraqi patients with active RA and to assess the predictors of response to RTX in treatment of Iraqi patients with active RA.Patients and methods An open labeled single group longitudinal study that was conducted over 13 months on 65 patients with RA diagnosed according to 1987 American College of Rheumatology (ACR) criteria. All patients were given 4 doses RTX by intravenous infusion over 6 months 1gm/dose. Each patient was followed at each visit for disease activity including Clinical Disease Activity Index (CDAI) and functional class (F Class). Also we assess 9 different patients’ characteristics (age, gender, disease duration, the presence of RF, presence of ACPA, smoking status, previous use of TNF - blocker, the use of methotrexate and BMI) as predictors to RTX .Results : Data analysis showed significant improvement in disease activity (CDAI) (P=0.005) and functional disability (P=0.001), Hb level (p= 0.005) and ESR (P=0.005) with RTX use over 6 months. The analysis also showed that smoking has a negative correlation with response to treatment (p= 0.005). Better response was seen in RF positive group. The other variables had no effects on the response to treatment. The patients who switched from TNF - blocker were (29), the patients who started on RTX were 36 (either due to positive PPD or unavailability of either due to positive Purified Protein Derivative of tuberculin test PPD or TNF - blocker ), result show same RTX efficacy in both groups.Conclusion : * RTX is effective both clinically CDAI (0.005), functionally F Class (0.005) and in lab. measures (ESR (0.005)) . * It is more effective in patients who are not smokers (0.005). * RXT was more effective in those who are seropositive for RF. * RTX safe with few side effects, tolerable by most patients. Most common side effect is transfusion reaction in form of sore throat (17 pt.) * Hb. Level increased significantly with the treatment (p= 0.005

انتشار ومحددات قلة النشاط البدني بين مرضى داء السكري و\ او ارتفاع ضغط الدم في محافظة بغداد, العراق, 2015 - 2016 == PREVALENCE AND DETERMINANTS OF PHYSICAL INACTIVITY AMONG DIABETIC AND/OR HYPERTENSIVE PATIENTS, BAGHDAD PROVINCE, IRAQ, 2015 - 2016

اسم المؤلف: مناف فائق احمد
اسم المشرف: فارس حسن اللامي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الخلفية : ان انتشار الامراض غير المعدية في تزايد في جميع انحاء العالم مع 80% من وفيات الامراض غير المعدية تحدث في البلدان المنخفضة والمتوسطة الدخل. هذه الامراض عادة ما تكون الاصابة بها ذات مدة طويلة ، وكذلك بطيئة التقدم . وعلى الصعيد العالمي ، كانت عوامل الخطر الغذائية وقلة النشاط البدني المسؤولة عن اكبر اعباء المرض. سنويا الخمول البدني يسبب حوالي 3.2 مليون حالة وفاة و69.3 مليون سنة مصاحبة للعجز ( 2.8% من المجموع الكلي) على مستوى العالم.اهداف الدراسة : لقياس مدى انتشار وتحديد الفئات عالية الخطر والمعرضة لقلة النشاط البدني بين البالغين الذين يعانون من ارتفاع ضغط الدم و/ او مرض داء السكري في محافظة بغداد, 2015 - 2016 . الاشخاص وطرق العمل : هذه دراسة مقطعية اجريت على عينة من 584 من البالغين الذين يعانون من ارتفاع ضغط الدم و/ او مرض السكري في بغداد (عمر ≥ 18 عام) والذين حضروا الى مراكز الرعاية الصحية الاولية والعيادات الطبية الشعبية. الذكور والاناث الذين تتراوح اعمارهم بين 18 عام او اكثر والذين حضروا لاي سبب الى مراكز الرعاية الصحية الاولية او العيادات الطبية الشعبية المختارة بالدراسة. تم استبعاد المرضى الذين لديهم اي حالات مرضية تتداخل مع النشاط البدني من الدراسة. وبالمثل، استبعدت ايضا الذين يعانون من مضاعفات خطيرة تجعل المقابلة غير مجدية. وقد تم تطبيق نوعين مختلفين من الاستبيانات لجميع الحاضرين لجمع المعلومات المطلوبة. تم ملئ الاستبيانات من قبل الباحث من خلال المقابلة المباشرة مع المشاركين في الدراسة وتم استخدام الاستبيان الاول لجمع المعلومات الاجتماعية والديموغرافية للمشاركين. الاستبيان الثاني (GPAQ) يحتوي على 16 بند خاصة بالنشاط البدني وضعتها منظمة الصحة العالمية وسجل حسب البروتوكولات القياسية المستخدمة لقياس المتغيرات النشاط البدني. اي درجة لمعامل التمثيل الغذائي (MET) اقل من 600 في الاسبوع فانها تمثل قلة النشاط البدني. النتائج : شملت هذه الدراسة 584 مريضا بارتفاع ضغط الدم او \ وداء السكري. كان معدل اعمار المرضى هو 48.9 ± 11.8 سنة. كان 57.2% منهم اناث. 69.5% منهم كان متزوج و82.5% منهم كانوا من المناطق الحضرية. 73% منهم كانوا مصابين بارتفاع ضغط الدم و53.3% كانوا مصابين بداء السكري (92% من النوع الثاني) وان 27.1% كانوا مصابين بدائي السكري وارتفاع ضغط الدم معا. 45% لم يكملوا الدراسة الثانوية وان 84.4% من الاناث ربات بيوت. 72% من الذكور كانوا موظفين او مرتبطين بعمل. 71% من المشاركين كانوا غير مدخنين وكذلك 92.5% من المشاركين غير متعاطين للكحول وان 47.4% من المشاركين يعانون من السمنة.كان انتشار الخمول البدني بنسبة 57.5% (فاصل الثقة 95% : 53.49 - 61.51). في مجتمع الدراسة وجد ان المجال الاقل نشاطا هو وقت الفراغ (6.7%) مقارنة مع مجالات العمل (45.7%) والنقل (47.6%). وكشف تحليل الانحدار اللوجستي عوامل الخطورة التالية : الشيخوخة ( 1.047=OR)، مطلق / ارمل (1.323=OR)، متقاعد / ربات البيوت (1.331=OR)، ومستوى الاميين من التعليم (1.439=OR)، والسمنة (1.46=OR) وعدم وجود المشورة المتعلقة بفوائد النشاط البدني (3.443=OR).الاستنتاجات : اكثر من نصف مرضى ارتفاع ضغط الدم و/ او داء السكري هم غير نشطين بدنيا. وكان التعليم المنخفض، والسمنة وقلة المشورة المتعلقة بفوائد النشاط البدني اهم عوامل الخطورة القابلة للتعديل. | Background : The prevalence of Non communicable diseases is increasing throughout the world with 80% of NCDs mortality occurring in low - and middle - income countries (LMICs) (Lee et al 2015). They are generally of long duration, and slow progression. Globally, dietary risk factors and physical inactivity were responsible for the largest disease burden. Physical inactivity causes around 3.2 million deaths and 69.3 million DALYs (2.8% of the total) globally, each year (Lim et al 2012). The Objective of this study is to measure the prevalence and identify high risk groups of physical inactivity among adults with hypertension and/or diabetes in Baghdad, Iraq, 2015 - 2016.Subjects and Methods : A cross - sectional study conducted on a sample of 584 adults with hypertension and/or diabetes in Baghdad (age ≥ 18 years) who attended primary health care centers and Medical Popular Clinics. Male and female individuals aged 18 years or more who attended the selected PHCCs or MPCs for any complaint. Patients that have any comorbid illnesses that interfere with physical activity were excluded from the study. Similarly, those with severe complications that make the interview not feasible were also excluded. Two different types of questionnaires had been applied to all attendants to collect needed information, the questionnaires were filled by the researcher through direct interview with the study population. First questionnaire was used to gather socio - demographic information of the participants. Second one was the 16 - item Global Physical Activity Questionnaire (GPAQ) (developed by WHO and incorporated within the WHO Stepwise instrument), scored as per standard protocols used to measure the physical activity variables. A metabolic equivalent task (MET) score of less than 600 per week indicates physical inactivity.Results : This study involved 584 HYN and/or DM patients. The mean age of the patients was 48.9±11.8 years; 57.2% were females; 69.5% were currently married; and 82.5% were from urban areas. Around 73% had HTN, 53.3% had DM (92% type2 DM), and 27.1% had both HTN and DM. About 45% didn’t complete their secondary school; 84.4% of females were housewives, and 72% of males were currently employed. Around 71% were non - smokers; 92.5% were non - alcohol drinkers; and 47.4% were obese. The prevalence of physical inactivity was 57.5% (95% CI : 53.49 - 61.51%). The study population was found to be least active in the leisure time domain (6.7%) compared with the work (45.7%) and transport (47.6%) domains. Logistic regression analysis revealed the following risk factor : Aging (OR=1.047), Divorced/Widowed (OR=1.323), Retired/housewives (OR=1.331), Illiterate level of education (OR=1.439), obesity (OR=1.46) and lack of physical activity advice (OR=3.443).Conclusion : More than half of hypertension and/or diabetes subjects were physically inactive. Low education, obesity and lack of advice were the most important modifiable risk factors affecting PA

تقييم تاثيرات المتفورمين والستاقلبتين على تفاعلية الاوعية الدموية الدماغية لدى مرضى السكري من النوع الثاني بواسطة دوبلر الدماغ : دراسة سريرية مقارنة == Evaluation The Effects of Metformin and Sitagliptin on Cerebral Vasoreactivity in Diabetic Patients (Type 2) By Transcranial Doppler : A Comparative Clinical Study

اسم المؤلف: احمد محمد حسن المظفر
اسم المشرف: حيدر كاظم حسون | محمد رشاد ابراهيم
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: ان مرض السكري من النوع الثاني يزيد من خطر الاصابة بالجلطة الدماغية ب (3 - 6) اضعاف وذلك بسبب اضطراب وظيفة النسيج الطلائي للاوعية الدموية وما ينتج عنه من تصلب مبكر لشرايين الجسم بشكل عام ومنها شرايين الدماغ. ان الكشف والعلاج المبكرين لذلك يقلل من خطر الجلطة الدماغية. ان جهاز دوبلر الدماغ هو جهاز لفحص شرايين الدماغ ومن الممكن تطبيق بعض الاختبارات الفسلجية لفحص مرونة وتفاعلية شرايين الدماغ.لقد اثبتت الدراسات السابقة ان ضعف تفاعلية شرايين الدماغ يزيد من احتمالية الاصابة بالجلطة الدماغية ولذلك من الممكن تقييم تاثيرات الادوية المستخدمة لعلاج داء السكري من النوع الثاني على تقليل خطر الاصابة بالجلطة الدماغية.هدف الدراسة : لقد اجريت هذه الدراسة من اجل تقييم تاثيرات عقاري المتفورمين والسيتاقلبتين والجمع بينهما على تفاعلية الاوعية الدموية الدماغية في مرضى السكري من النوع الثاني والمشخص حديثا باستخدام جهاز دوبلر الدماغ.طريقة العمل : اجريت هذه الدراسة في عامي (2015 - 2016) وقد شارك في الدراسة 182مريضا جميعهم من المصابين بداء السكري من النوع الثاني والمشخص لديهم حديثا. تم استبعاد مائة وثلاث مرضى اما الباقين تم تقسيمهم الى اربعة مجاميع. المجموعة الاولى هي مجموعة الضبط (وشملت 20 مريض) حيث تم علاجهم بواسطة ضبط النظام الغذائي وممارسة الرياضة فقط اما المجموعة الثانية فقد تم علاجهم بعقار المتفورمين بجرعة قدرها خمسمائة ملغرام مرتين يوميا لمدة ثلاثة اشهر اضافة الى ضبط النظام الغذائي وممارسة الرياضة للاقلال من وزن الجسم ووشملت 20 مريض . اما المجموعة الثالثة فقد تم علاجهم بعقار السيتاقلبتين عن طريق الفم مرتين يوميا لمدة ثلاثة اشهر وبجرعة قدرها خمسون ملغرام اضافة الى ضبط النظام الغذائي وممارسة الرياضة وشملت 19 مريض. اما المجموعة الرابعة فقد عولجوا بالسيتاقلبتين والمتفورمين مجتمعين مع ضبط النظام الغذائي وممارسة الرياضة ايضا وشملت 20 مريض. وقد اخذت موافقة جميع المرضى شفهيا قبل المشاركة. بعد ذلك تم اجراء الفحوصات المختبرية وفحص دوبلر الدماغ للشريان المخي الاوسط وتم تسجيل سرعة جريان الدم الانقباضية والانبساطية والوسطى وتم تسجيل معامل مقاومة الشريان ومعامل القدرة الانبساطية والانقباضية للشريان. ثم تم فحص تفاعلية الشريان المخي الاوسط بواسطة قياس مؤشر كتم النفس ومؤشر مدى التوسع الكامل للاوعية الدموية ومقياس فرط جريان الدم لكل مريض قبل وبعد ثلاثة اشهر من العلاج.النتائج : سجلت جميع مجاميع الدراسة زيادة ذات دلالة احصائية في مؤشر كتم النفس الا ان اكثرها قوة كان في المجموعة الرابعة (مجموعة الجمع) حيث كانت الزيادة من 0.64±0.029)) الى (0.87±0.035) مقارنة بالمجموعة الاولى (مجموعة الضبط) حيث كانت الزيادة من (0.67±0.027 ) الى (029 ( 0.72±0.اما بالنسبة الى مؤشر مدى التوسع الكامل للاوعية الدموية , لم تظهر جميع مجموعات الدراسة زيادة ذات دلالة احصائية في هذا المؤشر الا المجموعة الرابعة (مجموعة الجمع) حيث اظهرت هذه المجموعة زيادة ذات دلالة احصائية في هذا المؤشربعد العلاج من 30.3±1.18%)) الى (35.75±2.09%) .وفيما يتعلق بمقياس فرط جريان الدم , لم تظهر المجموعة الاولى (مجموعة الضبط) فرق ذو دلالة احصائية بعد العلاج بينما اظهرت المجموعتين الثانية والثالثة (مجموعتي المتفورمين والسيتاقلبتين) زيادة ذات دلالة احصائية وقد اظهرت المجموعة الرابعة (مجموعة الجمع) الزيادة الاكبر في هذا المقياس من بين جميع مجموعات الدراسة من ) 1.24±0.057) الى ( 1.59±0.06) .الاستنتاجات : 1. ان ادوية الميتفورمين والسيتاقلبتين منفردة زادت بصورة ملحوظة من تدفق الدم الانبساطي من للشريان المخي الاوسط وتخفيض RI وPI هذا التاثير اكثر وضوحا عندما يتم اعطاء كل من الدوائين معا مما يزيد من مرونة شرايين الدماغ.2. ان ممارسة الرياضة وبرنامج الحمية الغذائية زاد من مؤشر كتم التنفس كما الميتفورمين وعلاج السيتاقلبتين. ومع ذلك، فان التاثير اكثر وضوحا مع مزيج من الميتفورمين والسيتاقلبتين.3. ان ممارسة الرياضة وبرنامج الحمية الغذائية ،وادوية الميتفورمين والسيتاقلبتين لا يزيد مقياس مدى التوسع الكامل للاوعية الدموية او مقياس فرط جريان الدم في المرضى الذين يعانون من النوع 2 من داء السكري الذي اكتشف لديهم حديثا. بينما الجمع بين علاج الميتفورمين والسيتاقلبتين له تاثير اكثر اهمية في مقياس مدى التوسع الكامل للاوعية الدموية او مقياس فرط جريان الدم.4. وقد وجدت الدراسة وجود تناسب عكسي ذا دلالة احصائية واضحة بين نسبة السكر في الدم ومعدل السكر التراكمي من جهة ومقاييس تفاعلية الاوعية الدموية الدماغية (مؤشر كتم التنفس ومؤشر فرط جريان الدم ) من جهة اخرى.5. ان الجمع بين عقار المتفورمين والسيتاقلبتين في علاج مرضى السكري من النوع الثاني يقلل خطر الاصابة بالجلطة الدماغية من خلال زيادة كل مقاييس تفاعلية الاوعية الدموية الدماغية (مؤشر كتم النفس ومقياس مدى التوسع الكامل للاوعية الدموية ومؤشر فرط جريان الدم ) | Diabetes mellitus type 2 increases the risk of stroke 3 folds. It do so by inducing endothelial injury and accelerated atherosclerosis. Early diagnosis and treatment lower the risk of stroke. Transcranial Doppler examination applied with certain physiological tests can be used to test vasoreactivity of intracranial arteries. Impaired cerebral vasoreactivity can predict the risk of stroke. Therefore , this diagnostic test can be used for evaluation the effect of oral hypoglycemic drugs on risk of stroke. This study was conducted for evaluation and comparison of the effects of metformin, sitagliptin and their combination on cerebrovascular reactivity in patients with newly diagnosed type 2 diabetic patients. A total of 79 patients were involved in this study. They are all with newly diagnosed type 2 diabetes mellitus. They were divided into four groups; control, metformin, sitagliptin and combination. A verbal consent were taken from each participant. Control group includes twenty patients and was treated with dietary control and regular exercise. Metformin group includes twenty patients and was treated with metformin 500mg twice daily plus dietary control and exercise. Sitagliptin group includes nineteen patients and was treated with sitagliptin 50mg twice daily plus dietary control and regular exercise. Finally, combination group includes twenty patients and was treated with dietary control and regular exercise plus metformin 500mg with 50mg of sitagliptin twice daily. Treatment duration was three months. Biochemical tests were done before and after treatment. Measurement of hemodynamic parameters including systolic, diastolic and mean velocities with pulsatility and resistive indices was done by transcranial Doppler before and after treatment. Vasoreactivity measures which include breath - holding index, FRVD and transient hyperemic response rate ,all were recorded for each patient before and after treatment. In control group, there was significant statistical increase in breath - holding index from (p=0.008). In metformin group, breath - holding index also significantly increased (p<0.000). In sitagliptin group, breath holding index showed significant increase (p<0.000). Finally, combination group showed highest level after treatment among study group (p<0.000). Regarding FRVD; control group revealed insignificant statistical difference after treatment (p=0.702). Metformin group showed increase in FRVD it was statistically insignificant (p=0.071). Sitagliptin group exhibited non - significant statistical difference in FRVD (p=0.701). On the other hand, combination group revealed significant statistical increase in FRVD (p=0.001). In control group, THRR increased after treatment but it was insignificant change (p=0.209). Metformin group showed increase in THRR which was significant change (p=0.019). Sitagliptin group showed significant increase in THRR (p<0.000). Finally, combination group showed significant statistical increase in THRR (p=0.0003) which was the highest value among groups after treatment. From the results obtained in this study we can conclude that treatment with metformin plus sitagliptin increase all parameters of cerebral vasoreactivity in this study. Furthermore, decrease in fasting blood sugar and HbA1c correlates inversely with increase in breath - holding index after treatment

تاثير عقار السيتاقلبتين على الصدفية المزمنة من النوع اللويحي لدى مرضى السكري في العراق == Effect of Sitagliptin on chronic plaque psoriasis of diabetic patients in Iraq

اسم المؤلف: سرمد نوري الدجيلي
اسم المشرف: نصير عبد الامير الحرجان | محسن عبد الحسين الظالمي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: مرض الصدفية يعتبر من الامراض المزمنة النظامية المعقدة والمحفزة مناعيا بواسطة خلية المناعة من نوع ت ويتميز بلويحات حمراء مقشرة من الجلد والمفاصل. وقد حفز وسطاء الالتهابات 17IL - ,TNF - α وIL - 6 وربما عملية الجهد الناكسدي على انقسام خلايا بشرة الجلد وتمايزها مما ادى الى ظهور الصفات المميزة للمرض. مرضى الصدفية مع النوع اللويحي لا سيما مع ارتفاع مؤشر كتلة الجسم لديهم خطر الاصابة بمرض السكري من النوع الثاني وارتفاع الدهون. العلاجات الحديثة البيولوجية للمرض مثل مضادات α - TNF ومضاد ustekinumab) IL - 17) قد اسفرت عن نتائج افضل من العلاجات التقليدية غير ان استخدامها قد انحسر لعدد قليل من المرضى لما لها من اثار جانبية خطيرة. السيتاقلبتين يعتبر من الكابحات لانزيم الدايبيبتديل ببتايتيز4 وله تاثير مضاد للالتهابات للمرضى الذين يعانون من داء السكري من النوع الثاني وبدون اي تاثيرات جانبية . ولذلك فان الهدف من الدراسة الحالية هو تقييم اثر السيتاقلبتين على درجة باسي عبر التداخل مع معلمات متلازمة الايض, وسطاء الالتهابات وعلامات الاجهاد التاكسدي لمرضى الصدفية المصابين بالسكري من النوع الثاني.المرضى وطرق العمل : لقد اجريت الدراسة على 48 مريضا مصابا بمرض الصدفية يعانون من داء السكري وتم تقسيمهم الى مجموعتين : مجموعة البلاسيبو (ن = ٢٤) : اعطيت١٠٠ملغم من كبسولة البلاسيبو مرة واحدة يوميا بالاضافة الى مراقبة النظام الغذائي وممارسة التمارين الرياضية لمدة ١٢ اسبوع. مجموعة السيتاقلبتين (ن = ٢٤) : اعطيت قرص السيتاقلبتين ١٠٠ملغم مرة واحدة يوميا بالاضافة الى مراقبة النظام الغذائي وممارسة التمارين الرياضية لمدة ١٢ اسبوع. وقد تم الحصول على عينات الدم من المرضى في كلا المجموعتين قبل وبعد استخدام ١٢ اسبوعا من العلاج لقياس تركيز المصل من السكر بعد الصيام ، HbA1c، الدهون الثلاثية، الكولسترول، البروتين الدهني منخفض الكثافة ،البروتين الدهني منخفض الكثافة جدا ،البروتين الدهني عالي الكثافة ، α TNF - ، IL - 17، IL - 6، IL - 10، MDA وGSH، ودراسة العلاقة مع درجة باسي بعد ١٢ اسبوعا من العلاج. تم اجراء الخزعات من نوع لكمة مع قطر ۵ملم سمك لكلا المجموعتين قبل وبعد ١٢ اسبوعا من العلاج وارسالها للفحص النسيجي.النتائج : مقارنة مع خط الاساس في مجموعة السيتاقلبتين ومجموعة البلاسيبو بعد ١٢ اسبوعا من العلاج مستوى السكر بعد الصيام، نسبة HbA1c، الدهون الثلاثية، الكولسترول، البروتين الدهني منخفض الكثافة ، البروتين الدهني منخفض الكثافة جدا، TNF - α ، IL - 17 وIL - 6في مصل الدم اظهرت انخفاضا معنويا (0.05 >P) بعد ١٢ اسبوعا من العلاج بالسيتاقلبتين وارتباطا ملحوظا موجبا مع درجة باسي (0.05 >P) . في المقابل مستوى البروتين الدهني عالي الكثافة، IL10 وGSHفي الدم اظهرت ارتفاعا معنويا (0.05 >P) بعد ١٢ اسبوعا من العلاج بالسيتاقلبتين وارتباط سلبي ملحوظ مع درجة باسي (0.05 >P) . وكشف فحص الانسجة تغييرات معنوية (0.05 >P) بعد ١٢ اسبوعا من العلاج بالسيتاقلبتين في الصفات النسيجية للبشرة والخلايا اللمفاوية المتسللة لادمة الجلد بالمقارنة مع قبل العلاج لمجموعة السيتاقلبتين وبعد١٢ اسبوعا من العلاج لمجموعة البلاسيبو ولا يوجد اي تاثير معنوي على الاوعية الدموية لادمة الجلد.الاستنتاج : كشفت الدراسة ان السيتاقلبتين قد خفض درجة باسي دون غياب كامل للويحات الصدفية من خلال تحسن ارتفاع السكر في الدم، الدهون، وسطاء الالتهابات او السيتوكينات ومسارات الاجهاد التاكسدي مع تاكيد النتائج السريرية والمناعية من حلال التحسن الملحوظ في التغييرات النسيجية المرضية . | Psoriasis represents a complex chronic systemic T cell immune - mediated inflammatory disease characterized by erythematous, scaly plaques of skin and joints. Inflammatory mediators such as IL - 17, IL - 6, TNF - α and possibly oxidative stress process have stimulated abnormal proliferation of keratinocytes and differentiation resulting in characteristic appearance of psoriasis. Psoriatic patients with plaque psoriasis particularly those with high body mass index have increasing risk of developing a diabetes mellitus type 2 (DM2) and hyperlipidemia. Advance treatment of psoriasis with biological agents such as TNF - antagonists and IL - 17 antagonist like ustekinumab have been tried with a better result than traditional treatment. However their use have been limited in some patients, because of severe side effects. Sitagliptin is a dipeptidyl peptidase - IV (DPP - IV) inhibitor exerts anti - inflammatory effect when used in patients with type 2 diabetes without any reported severe side effects. Therefore the objective of current study was to assess the effect of Sitagliptin on psoriasis area and severity index (PASI) score in psoriatic patients with diabetes via interfering with metabolic syndrome parameters, inflammatory mediators and oxidative stress markers.Patients and Methods The study was conducted on 48 diabetic patients with moderate to severe plaque psoriasis who were divided into two groups : Placebo group (n=24) patients were administered placebo once daily plus dietary control and exercise for 12 weeks ; Sitagliptin group (n=24) patients were administered Sitagliptin tablet 100mg once a day plus dietary control and exercise for 12 weeks. PASI score for all patients was assessed before and after 12 weeks of treatment. The fasting blood samples were obtained from the patients in both groups at baseline and after 12 week of therapy used to measure the concentration of serum fasting blood sugar (FBS), HbA1c, triglyceride(TG), cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), tumor necrosis factor alpha (TNF - α), intreleukin - 17 (IL - 17), intreleukin - 6 (IL - 6), intreleukin - 10 (IL - 10), malondialdehyde (MDA) and reduced glutathione (GSH), and to determine their correlation with PASI score after 12 weeks of treatment. Punch biopsies with size of 5mm diameter were performed for both groups at baseline and after 12 week of treatment and sent for histopathological examination and psoriasis histopathological score (PHS) was measured for patients in both groups at baseline and after 12 week of treatment. Results : Compared with baseline in Sitagliptin group and placebo group after 12week, the level of PASI score was significantly reduced (P < 0.05) after 12 weeks of Sitagliptin treatment. The level of FBS, HbA1c, TG, cholesterol, LDL, VLDL, TNF - α, IL - 17, IL - 6 and MDA were significantly reduced (P < 0.05) after 12 weeks of Sitagliptin treatment when compared with baseline in Sitagliptin group and placebo - treated group after 12 week and positively correlated (P < 0.05) with PASI score. In contrast the level of HDL, IL10 and GSH were significantly increased (P < 0.05) after 12 weeks of Sitagliptin treatment in comparison to baseline in sitagliptin group and with that of placebo - treated group after 12week and negatively correlated with PASI score (P < 0.05). PHS was significantly reduced (P < 0.05) after 12 weeks in comparison to baseline in Sitagliptin - treated group and with that of placebo - treated group after 12 week. Histopathological examination also revealed a significant improvement (P < 0.05) in epidermal histological features and dermal lymphocytic infiltration with no effect on dermal blood vessels.Conclusion The present study revealed that Sitagliptin reduce PASI score without complete absence of psoriatic plaques via an improvement in hyperglycemia, hyperlipidemia, inflammatory mediators or cytokines and oxidative stress markers with confirmation of our clinical and immunological results by significant improvement in PHS.

بعض مضادات الالتهابات اللاستيرودية المستخدمة في علاج الالام البسيطة على الاباضة في النساء : دراسة سريرية == Effects of Some Commonly Used COX - 1&COX - 2 NSAIDs in The Treatment of Minor Aches on Ovulation In Women (A CLINICAL STUDY)

اسم المؤلف: اسماء نجم عبد جواد
اسم المشرف: احمد محمود الزهيري | سامي سلمان شهاب
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعد الاباضة الوظيفة الاساسية للمبيض واضطراب هذه الوظيفة هو اهم اسباب عدم الخصوبة في الاناث . تعد الادوية اللاستيرودية المضادة للالتهابات من اكثر الادوية استعمالا وذلك لخواصها المسكنة للالم والخافضة للحرارة وكونها مضادة للالتهابات وقد ثبت ان هذه الادوية تؤثر على الاباضة في اجناس كثيرة من اللبائن التي جربت عليها هذه الادوية لحد الان ومن المرجح ان السبب هو في تثبيط هذه الادوية للانزيم المسؤول عن انتاج البروستوكلاندين.وعلى هذا الاساس فان المعالجة بمضادات الالتهابات اللاستيرودية قد تكون احد الاسباب التي تؤدي الى اضطرابات الخصوبة لدى النساء.الدراسة الحالية اجريت على نساء في سن الانجاب لاجل تقصي تاثير ادوية السيليكوكسيب وحامض الميفينامك والايبوبروفين على عملية الاباضة على ان الجرع المستعملة من الادوية اعلاه هي جرع علاجية عادية قياسية وان ادوية اخرى جربت سابقا في قسمنا ثبت انها تؤثر سلبا على الخصوبة .وان الادوية المستعملة في هذه الدراسة من اجيال مختلفة وواسعة الاستعمال في العلاج على مستوى الجمهور .وقد خلصت الدراسة الحالية الى النتائج التالية : - تثبيط مؤثر على الاباضة للادوية الثلاثة. - كان دواء السيليكوكسيب الاكثر فعالية في التاثير على الاباضة مقارنة مع الايبوبروفين وحامض الميفينامك. - انخفاض غير مؤثر في هورمون البروجستيرون في المجاميع العلاجية للادوية الثلاث. - لوحظ وجود تكيسات في مبايض النساء اللاتي عولجن بدواء السيليكوكسيب فقط ولم تلاحظ هذه الظاهرة في مجاميع العلاج للدوائين الاخرين. - لا يوجد اي تاثير على بطانة الرحم في المجاميع العلاجية للادوية الثلاث.ان النتائج المشار اليها اعلاه يجب ان تؤخذ على محمل الجد من قبل الاطباء المعالجين عند وصف الادوية المضادة للالتهابات اللاستيرودية اعلاه(السيليكوكسيب,ايبوبروفين,حامض الميفينامك ) للنساء في سن الانجاب والاتي يرمن انجاب اطفال تلافيا لتوقف الاباضة او حدوث تكيسات المبايض مما يؤثر سلبا على خصوبتهن. | Ovulation is the central event in ovarian physiology, and ovulatory dysfunction is a relevant cause of female infertility. Non - steroidal anti - inflammatory drugs (NSAIDs), are widely used due to their analgesic , antipyretic and anti - inflammatory properties, consistently inhibit ovulation in all mammalian species investigated so far, likely due to the inhibition of cyclooxygenase that is the rate limiting enzyme in prostaglandin (PG) synthesis. NSAID therapy is likely implicated in human infertility and could be an important, frequently overlooked, cause ovulatory dysfunction in women. The present study employed in women[52 patients plus 12 controls] attending Baghdad teaching hospital department of rheumatology to assess the effects of celecoxib, mefenamic acid and ibuprofen on ovulation. Doses used in this study,were therapeutic doses having effects on ovulation as appeared in previous studies carried out in this department. The non - steroidal anti - inflammatory drugs employed in the present study are from different generations ,well - known & widely used .The present study revealed the following findings : 1. A significant inhibition of ovulation have been observed in patients treated with celecoxib , ibuprofen & mefenamic acid.2. Celecoxib was the highest inhibitor of ovulation compared to the other two drugs ( ibuprofen & mefenamic acid ). 3. A non significant decrease in progesterone level in all three groups in compared to the control group.4. Functional cyst have been observed in patients treated with celecoxib,and no functional cyst occur in other two groups treated with mefenamic acid and ibuprofen.5. Endometerial thickness not affected in all three treated groups.The above findings should be kept in mind and taken in consideration by physicians when they prescribe NSAIDs[Celecoxib, Ibuprofen &mefenamic acid ] to treat female patients at child bearing age due to the inhibitory effects of these drugs on ovulation

تقييم تغيرات جين Topoisomerase II alpha بواسطة التهجين الموضعي الصبغي وعلاقته بمستقبل الاستروجين ER ومستقبل البروجستيرون PR ومعلم ki - وher2/neu67 في سرطان الثدي عند الانسان == Evaluation of Topoisomerase II alpha Gene Alterations by Chromogenic in situ Hybridization in Correlation with ER, PR, HER2/neu, and Ki?67 in Human Breast Cancer

اسم المؤلف: رشا عبد الرؤوف نعمة الصافي
اسم المشرف: منال عدنان حبيب | ساهرة عبود علي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض النسيجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Breast cancer is a clinically and biologically heterogeneous disease,Characterized by dys - regulation of multiple cellular pathways anddifferent sensitivities and responses to treatment. There is high tendencythat all diagnosed breast cancers should be tested for her2/neu oncogeneamplification with an in situ hybridization tests for further evaluation ofan equivocal cases (2+) detected by immunostaining.Topoisomerase II alpha gene is located on chromosome 17 adjacent toher2/neu gene, and Topoisomerase II alpha gene is responsible for codingtopoisomerases enzymes that modulate the topology of DNA duringcellular proliferative process. Topoisomerase II alpha is a moleculartarget for some important anticancer drugs, including anthracyclines,which are the key chemotherapeutic agents in the treatment of breastcancer.Fluorescent In situ hybridization is widely used technique in clinicaldiagnoses to identify oncogene amplification and chromosomaltranslocation in the cellular genome. Recently it was stated thatchromogenic in situ hybridization is regarded as a good alternative forfluorescent in Situ hybridization. Dual color - chromogenic in situhybridization combines the advantages of both FISH and CISH andallows the assessment of ratio of gene copy number to the chromosomalcentromere along with proper histopathological examination and the easeof bright - field microscopy.VIThe aim of the study is to evaluate Topoisomerase II alpha geneamplification and deletion by dual color chromogenic in situ hybridization in females with invasive breast cancer and to correlate Topoisomerase II alpha gene status with her2/neu, estrogen receptor, progesterone receptor and ki - 67 index and to detect the elation of Topoisomerase II alpha gene with clinico - pathological parameters like age, histological types, stage, grade and lymph node involvement in females with breast cancer.This study was done from July 2014 to February 2015. Females diagnosed to have invasive breast carcinoma reaching Oncology hospital in Baghdad Medical City were enrolled in the study. All females have been experienced modified radical mastectomy with axillary clearance. Immunohistochemical study for Estrogen receptor; Progesterone receptor; Her2/neu and Ki67 were done for their tissue blocks. Patients with Her2/neu equivocal (score 2+) and strong positive her2/neu (score 3+) were selected forming seventy five cases. Dual color chromogenic in situ hybridization was done in central public health laboratory/Baghdad for all cases for evaluation of topoisomerase 2 alpha gene and for further evaluation of her/neu in equivocal cases. Just 53 cases were successfully hybridized and enrolled in the study by applying Her2/neu and Topoisomerase II alpha genes probes. There was no topoisomerase II alpha gene deletion. No significant statistical relationship between topoisomerase alpha gene amplification and age, histological types of breast cancer, stage and lymph nodes while the relation was significant with the grades of breast cancer in that the highest level of gene amplification was in grade III detected in 9 (64.3%) of cases.There was a significant negative relationship between topoisomerase II alpha gene and hormone receptors (estrogen receptor and progesterone receptor) as the highest gene amplification was detected in hormone negative cases. The relation of topoisomerase II alpha gene with ki - 67 was not significant. After Chromogenic in Situ Hybridization study 12 (44.4%) out of 27 equivocal cases show her2/neu gene amplification as 4 (14.8%) cases and 8(29.6%) for high and low her2/neu gene amplification respectively.Accordingly the amplified cases of her2/neu gene were gathered with the strongly positive her2/neu cases from immunohistochemistry to form 38 (71.7%) out of 53 cases which representing the first group of total positive her2/neu cases out of total 53 cases. The second negative her2/neu group of 15 / 53 cases representing cases which were resulted from Chromogenic In Situ Hybridization study.The relation between topoisomerase II alpha gene and her2/neu gene was statistically significant in that 50% of her2/neu amplified cases show topoisomerase II alpha gene amplification (co - amplification). Thirty nine percent 39% of total positive 38 cases show Topoisomerase 2 alpha gene co - amplification, from these 11/ 28.9% cases show high level of amplification. .So a significant positive correlation of topoisomerase 2 alpha gene with her2/neu and its negative correlation with estrogen and progesterone receptors may indicate that it could be considered as a bad prognostic factor.

تاثير الاجسام المضادة لل انفلياكسيمب وعلاقتها مع مستضدات الكريات البيض البشرية - النوع الثاني - DRB1 في المرضى العراقيين المصابين بالتهاب المفاصل الرثوي == Influence of Anti - infliximab Antibodies and its Association with HLA - class II - DRB1 alleles in Iraqi patients with Rheumatoid arthritis

اسم المؤلف: محمد احمد الكرخي
الموضوع العام: الطب
السنة: 2016
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: التهاب المفاصل الرثوي هو مرض مزمن ذاتي المناعة يصيب عدة اعضاء من الجسم ومن ضمنها المفاصل ويمكن ان يؤدي الى تدمير المفاصل والعجز الشديد اذا لم يعالج في وقت مبكر. المضادات لعامل نخر الورم عامل الفا (TNFα) مثل اينفلياكسيمب (INF) وهو من الاجسام المضادة وحيدة النسيلة خيالية ادخلت في عام 2010 من قبل وزارة الصحة كعوامل فعالة للغاية لعلاج المرضى العراقيين المصابين بالتهاب المفاصل الرثوي الحاد متوسط الشدة او الشديد الذي لا يستجيب للعلاج التقليدي.اينفلياكسيمب يمكن ان يحفز على تكوين الاجسام المضادة لعقار اينفلياكسيمب (ATIS)، ولكن هذه الاجسام المضادة من الممكن ان تؤدي الى نقص فعالية الاينفلياكسيمب او تاثيرات جانبية سلبية.وفقا لمعلوماتنا المتاحة انه لا توجد اية معلومات عن هذه الاجسام المضادة لل انفلياكسيمب وارتباطها مع النتائج السريرية، العلامات المصلية ومستضدات HLA - classІІ - DRB1 في المرضى العراقيين المصابين بالتهاب المفاصل الرثوي.وقد اجريت هذه الدراسة لاعطاء فكرة واضحة عن تكون ودور هذه الاجسام المضادة في الاستجابة السريرية للمرضى لعقار الاينفلياكسيمب وكذلك توضيح تاثير مستضداتHLA - classІІ - DRB1 على القابلية المناعية لعقار الانفلياكسيمب في تكوين هذه المضادات.المرضى والطرق : شملت الدراسة 100 شخص. حيث تضمنت ما مجموعه 50 مريضا الذين توافقوا مع المعايير المنقحة لمرض التهاب المفاصل الرثوي (الكلية الامريكية لامراض الروماتيزم 1987 و2010) في المواءمة مع 50 مجموعة السيطرة (25 اشخاص اصحاء و25 مرضى مصابين بالتهاب المفاصل الرثوي لم يعالجوا بعقار اينفلياكسيمب). وقد اجريت هذه الدراسة خلال الفترة من بداية شهراذار 2014 حتى نهاية شهر ايلول 2014 في وحدة العلاج البيولوجي لقسم امراض الروماتيزم / مستشفى بغداد التعليمي، مختبر الدراسات العليا / فرع الاحياء المجهرية / كلية الطب - جامعة بغداد، المختبرات التعليمية / مدينة الطب، وحدة زرع الكلى / مستشفى الكرامة التعليمي ومركز التطابق النسيجي البحثي / كلية طب الكندي / جامعة بغداد. تم جمع عينات الدم من مجموعة السيطرة والمرضى الذين يعانون من التهاب المفاصل الرثوي في والذين تمت معالجتهم بعقار الانفلياكسيمب لاكثر من ثلاثة اشهر لغرض تقييم الاجسام المضادة لعقار الاينفلياكسيمب،مضادات - CCP، بروتين سي التفاعلي والتنميط الجيني HLA - DRB1.المرضى الذين لم تتكون لديهم الاجسام المضادة لل انفلياكسيمب فتمت متابعتهم لمدة 6 اشهر واعادة فحصهم للتحقق من وجود الاجسام المضادة لل انفلياكسيمب,anti - CCP وبروتين سي التفاعلي.تم الكشف عن الاجسام المضادة لل انفلياكسيمب والاجسام المضادة لل CCP بواسطة جهاز فحص الانزيم الرابط المناعي (ELISA) ,اما بروتين سي التفاعلي(CRP) فتمت قياسته بواسطة جهازNephelometer في حين تم اجراء تحليل التنميط الجيني النوع الثاني DRB1 بواسطة بادئات محددة تفاعل البلمرة المتسلسل (PCR - SSO) لكل من المرضى ومجموعة السيطرة الاصحاء.النتائج : من اصل 50 مريض في الدراسة الحالية، كان متوسط العمر (45.24 ± 9.15سنة) وكانت الاناث اكثر من الذكور (اناث : ذكور 3 : 1).تم اكتشاف الاجسام المضادة لل انفلياكسيمب في خمسة وثلاثون مريض(70٪) من مرضى التهاب المفاصل الرثوي بعد فترة ثلاثة اشهر من العلاج بهذا الدواء, بينما لم تتكون هذه المضادات للعقار في 15 (30٪) منهم.في حين لم يتم الكشف عن اية اجسام مضادة في مجموعة السيطرة (الاصحاء ووالسيطرة المرضية)، كان الفرق على درجة عالية وذات دلالة احصائية (قيمةp = 0.000001)، ومع حساسية وخصوصية (70٪، 100٪) على التوالي. في نفس المدة من العلاج تم الكشف عن الاجسام المضادة لل - CCP في 47 (94٪) من المرضى بينما لم يتم اكتشاف هذه الاجسام المضادة في في 3 (6.0٪)منهم، في حين تم الكشف عن هذه الاجسام المضادة في 22 (88٪) من مجموعة السيطرة ولم يتم اكتشافها في 3 (12٪) منهم.بينما لم يتم اكتشاف اية اجسام مضادة لل - CCPفي مجموعة الاصحاء ,وكان الفرق معتد للغاية وذات دلالة احصائية (قيمة p=0.0005) مع حساسية وخصوصية (94٪، 100٪) على التوالي.تم توثيق علاقة قوية بين نشوء الاجسام المضادة للانفلياكسيمب والاجسام المضادة لل - CCP (قيمة p = 0.006).وفيما يتعلق بفحص بروتين سي التفاعلي، تم الكشف عنه في 26 (52٪) من مجموعةالمرضى بينما لم يتم الكشف عنه في 24 (48٪) منهم، كما انه كان ايجابيا في كل مجموعة السيطرة المرضية, بينما في مجموعة السيطرة للاصحاء، كان ايجابيا في 10 (40٪) وسلبيا في 15 (60٪) وكان الفرق ذات دلالة احصائية عالية (قيمة p= 0.000014) مع تدني في الحساسية والخصوصية (52٪، 60٪) على التوالي.ولم تسجل الدراسة الحالية اي ارتباط ذو قيمة بين نتيجة بروتين سي التفاعلي وتكون اضداد اينفلياكسيمب (قيمةp = 0.084).بالنسبة لمجموع المرضى الذين لم يتم اكتشاف اضداد ال انفلياكسيمب لديهم والبالغ عددهم 15 مريض فتمت متابعتهم بعد 6 اشهر من فترة العلاج بال انفلياكسيمب لغرض التحقق من احتمالية تكون الاجسام المضادة لل انفلياكسيمب ,اضافة الى اعادة فحص اضداد - CCPو بروتين سي التفاعلي ,اظهرت النتائج عن عدم وجود فرق احصائي بين نتائج الفحص بعد 3 اشهر وونتائج الفحص بعد 6 اشهر وكانت قيمة - p((0.067، 0.067 و1.0) على التوالي.وعلاوة على ذلك، كشفت الدراسة وجود علاقة ايجابية بين HLA - DRB1 * 04 (DR4) اليل مع 35 مريض مصاب بالتهاب المفاصل الرثوي تمت علاجهم بال اينفلياكسيمب حيث تمت مقارنتهم مع 25شخص من مجموعة السيطرة للاصحاء وكان الفرق ذات دلالة احصائية (قيمة p = 0.001).واخيرا كشفت الدراسة الحالية عن عدم وجود اي ارتباط بين HLA - DRB1 وتكون الاجسام المضادة لل اينفلياكسيمب في المرضى الذين يعانون من التهاب المفاصل الرثوي (قيمة p = 0.0914).الاستنتاجات : اظهرت الدراسة الحالية على ان ما يقرب من ثلاثة ارباع المرضى العراقيين المصابين بمرض التهاب المفاصل الرثوي تتكون لديهم الاجسام المضادة لل ااينفلياكسيمب بعد ثلاثة اشهر من العلاج مع هذا العامل البيولوجي مع عدم وجود اي ارتباط للعامل الوراثي (اليل DRB1 - HLAالنوع الثاني) مع تكونها، كما اثبتت الدراسة وجود ارتباط وثيق بين العامل الجيني الاليل( HLA - DRB1 * 04 (DR4مع نشوء مرض التهاب المفاصل الرثوي في المرضى العراقيين. | Rheumatoid arthritis is a systemic chronic autoimmune inflammatory polyarthritis leads to joints destruction and severe disability if not treated early. Tumor necrosis factor alpha antagonists such as infliximabwhich is a chimeric monoclonal antibody have been introduced and approved in 2010 by Ministry of Health as highly effective agents for the treatment of Iraqi patients with moderate to severe Rheumatoid arthritis that not responds to conventional treatment.Infliximab can induce formation of anti - infliximab antibodies, however, these antibodies may lead to lack of efficacy to Infliximab or adverse reactions.According to our knowlege no information is available about these antibodies to infliximab and their association with clinical findings , serological markers and HLA - class ІІ - DRB1 antigens in iraqi patients with Rheumatoid arthritis.The present study was conducted to give a clear idea about the development and the role of these antibodies in clinical response of patients to infliximab and demonstration the effect of HLA - class ІІ - DRB1 antigens on the immungenicity of infliximab. Patients and Methods : The study covered 100 subjects. It included a total of 50 patients who met the revised criteria for RA (the American College of Rheumatology 1987 and 2010) in aligment with the 50 control group(25 healthy individuals and 25 RA patients not treated by infliximab). This study was carried out during the beginning of March 2014 till the end of September 2014 in the Biological Therapy Unit of the Deparment of Rheumatology/Baghdad Teaching Hospital, the laboratory for Higher Studies/Microbiology Deparment/Baghdad College of Medicine, the Teaching Laboratories/Medical City, the Kidney Transplant Unit/ Al - Karama Teaching Hospital and HLA Research Center /Al - kindy College of Medicine/Baghdad University. Blood samples were collected from control group and patients with RA on infliximab therapy for more than three months duration for assesment of antibodies to infliximab , anti - Cyclic Citrullinated Peptide(anti - CCP) ,C - reactive Protein(CRP) and for Human Leukocyte Antigen - DRB1(HLA - DRB1) genotyping.The patients with negative anti - infliximab antibodies were follow up and reinvestigated after 6 month of infliximab therapy for anti - infliximab antibodies, anti - cyclic citrullinated peptide and C - reactive Protein.Anti - bodies to infliximab and anti - Cyclic Citrullinated Peptide antibodies were detected by Enzyme Link Immunosorbent Assay (ELISA), the C - reactive protien (CRP) was measured by Nephlometer . whereas the genotyping analysis for HLA - class ІІ - DRB1 had been done by polymerase chain reaction - sequence specific primers (PCR - SSO) for both patients and healthy control group.Results : Out of 50 case study group included in the current study, their mean age was (45.24± 9.15) the females were predminance than males in a ratio (F : M 3 : 1).Thirty five (70%) of RA patients developed antibodies against infliximab after three months of treatment with this drug ,15 (30%) of them were negative for these antibodies, while no anti - inflixmab antibodies were detected in control groups( (healthy and case control) ,the difference was a highly statistically significant(P - value=0.000001), and with sensitivity and specificity (70 %,100%) respectively.At the same duration of treatment the anti - CCP was detected in 47 (94%) patients and negative in 3 (6.0%), while in case control was postive in 22 ( 88%) and negative in 3(12%), and was not detected in all healthy control group,the difference was highly satistically siginficant ( p - value =0.0005) with sensitivity and specificity (94%,100%) repectively.A strong correlation was reported between the development of anti - infliximab and anti - CCP antibodies (p - value=0.006).Regarding the CRP test ,it was positive in 26 (52%) patients and negative in 24 (48%), also it was positive in all case control group while in healthy control group ,it was reported positive in 10(40%) and negative in 15(60%) with highly statistically significance(p - value=0.000014) with low sensitivity and specificity (52%, 60%) respectively.No significant correlation was reported between CRP and development of anti - infliximab antibodies (p - value=.084).Fifteen patients group with negative anti - infliximab antibodies were follow up and re - investigated after six months of treatment with infliximab for anti - infliximab ,anti - CCP antibodies and CRP, the results showed no statistical difference of these test after three and six month of infliximab treatment with p - value (0.067, 0.067 and 1.0) respectively.The study revealed a positive association of HLA - DRB1*04(DR4) allele with 35 patients with RA on infliximab therapy whom compared with 25 healthy control and the difference was statistically significant (p - value=0.001).There was no association found between the HLA - DRB1 and development of antibodies to infliximab in patients with RA (p - value=0.0914).Conclusions : The current thesis showed that approximately three quarter of Iraqi patients with RA developed antibodies against infliximab after three months of treatment with this biological agent and without association of genetic factor( HLA - class ІІ - DRB1 alleles) with their development ,also the study suggested an association of susceptibility of RA in Iraqi patients with HLA - DRB1*04(DR4).

دور Foxp جين والاحماض النووية الرايبوية متناهية الصغر ,145 ,146a ,20aفي عينة من المرضى العراقيين المصابين بمرض تصلب الاعصاب المنتشر == The Role of Foxp3 and MicroRNAs (20a, 146a, 145, and 155) in a Sample of Iraqi patients with Multiple sclerosis

اسم المؤلف: زينب عبد الاله عبد الجواد الجوادي
اسم المشرف: عائدة رشيد منصور الدرزي | بان عباس عبد المجيد
الموضوع العام: الطب
السنة: 2016
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Multiple sclerosis is a devastating central nervous system autoimmune disorder that is characterized by a series of inflammations, demyelinations, and neurodegenerations that affect the brain and spinal cord. The epigenetic studies specially micro Ribonucleic acid expression represent an important field of researches that probably uncover the obscurities behind the multiple sclerosis pathogenesis. The aims of the present work were to study the expression of micro Ribonucleic acids (20a, 146a, 155, and 145) and forkhead box P3 genes by real time polymerase chain reaction relative quantification technique, to correlate their expression according to different clinical parameters, and to perform chromosomal analysis on the multiple sclerosis patients peripheral blood lymphocytes. A case - control study was performed on 25 newly diagnosed untreated multiple sclerosis patients during their attendance to Multiple Sclerosis clinic, or during their admission to the Neuromedical ward (10th floor) in Baghdad Teaching Hospital, and Special Nursing Home (5th floor) in Baghdad Medical City as well as from the Neuromedical Consultancy Unit in Al - Yarmouk Teaching Hospital in Baghdad city, in addition to 25 apparently healthy controls which were medical staff with no history of having any autoimmune disease or receiving any steroid or immunomodulatory therapy. Furthermore, chromosomal analysis was performed for multiple sclerosis patients. This work was conducted during the period from 1st of April 2015 to 31st of March 2016.From a total of 25 multiple sclerosis patients, 23 of them were females and 2 were males with a female to male ratio (F : M) of 11.5 : 1. The ages of these patients ranged between 18 - 55 years; mean age was 33.32 + 9.45 years. Studying of micro Ribonucleic acids expression revealed a significant down - regulation in micro Ribonucleic acid - 20a and forkhead box P3 gene while up - regulation of micro Ribonucleic acid - 155 expression in multiple sclerosis patients in comparison to controls. Micro Ribonucleic acid - 146a was directly associated with inflammation, and multiple sclerosis disease activity. On the other hand, micro Ribonucleic acid - 145 was not associated with significant changes in its expression in relation to multiple sclerosis disease. Chromosomal analysis was done for multiple sclerosis patients and it was normal.In conclusion, multiple sclerosis is associated with significant changes in micro Ribonucleic acids expression including micro Ribonucleic acid - 20a, micro Ribonucleic acid - 146a, and micro Ribonucleic acid - 155 but not micro Ribonucleic acid - 145 as well as to a significant change in forkhead box P3 gene expression that can be measured by real time polymerase chain reaction technique. Furthermore, multiple sclerosis is not associated withgross chromosomal abnormalities.

ظاهرة التنمر ضمن طلاب المدارس الاعدادية في بغداد - الكرخ == BULLYING AMONG STUDENTS IN HIGH SCHOOLS IN BAGHDADKARKH

اسم المؤلف: حيدر مجيد يحيى
اسم المشرف: مشتاق طالب هاشم
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Bullying is a major public health problem especially among students in high schools.Literature showed that bullying have an effect on mental, social, emotional, general behavior and academic function of students in school.Objective : To explore the prevalence of bullying among students in intermediate and secondary schools in Baghdad.Subjects and methods : A multi - stage stratified random sample of (302) students from intermediate and secondary schools in Baghdad - Karkh was included in the study; collection of data was done from October to December 2014. Using Focus Group Discussion each participant was directly interviewed to complete a questionnaire which contains four elements. First element was contained the sociodemographic information, Second element was formulated to measure the bullying depending on “Factors associated with bullying behavior in middle school students” by Bosworth, Espelage and Simon, and “A comparison of the Gatehouse Bullying Scale and the Peer Relations Questionnaire for students in secondary school” by Bond, Wolfe, Tollit, Buttler and Patton, and “Development of the Multi - dimensional Peer Victimization Scale” by Mynard and Joseph. Third element was for measuring the frequency of symptoms of bullying, the statements were translated from a compendium of the National Center on Birth Defects andDevelopment disabilities, Centers for Disease Control and Prevention. Fourth element was to assess the posttraumatic stress symptoms by using Harvard Trauma Questionnaire - Iraqi version for trauma symptoms (Part IV).Chi - square was used to examine the association between independent variables (socio - demographic variables and traumatic events) with dependent variables (bully, victim and witness). P value < 0.05 was considered statistically significant.Results : The rate of bullies was 24.3%, rate of victims was 38.8%, rate of sexual bullies was 17.1%, and rate of sexual victims was 21.4%. There was no significant statistical association between age and bullying (P=0.3).A significant association was noticed between sex and bullying (P=0.001).Bullying was varied significantly between resident area (P=0.004). A significant association was found between bullies with smoking and failure in school (P=0.001 for each).Conclusion : High prevalence of bullying (bullies, victims, sexual bullies and sexual victims) was found among student. The smoking and substance use was reported among the participants of study.Key words : Bullying, victimization, war, PTSD, Iraq.

تقييم تضييق الصمام التاجي باستخدام طريقة PISA للمرضى العراقيين بواسطة الايكو == Assessment of Mitral Valve stenosis by Simplifying proximal Isovelocity surface area in Iraqi Patients by Trans thoracic Echocardiography

اسم المؤلف: محمد جاسم حتروش
اسم المشرف: غازي فرحان حاجي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: صدى القلب
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Mitral Stenosis refers to narrowing of the mitral valve orifice, resulting in impairment of filling of the left ventricle in diastole. It is usually caused by rheumatic heart disease. Proximal isovelocity surface area measurement, also known as the “flow convergence” method, can be used in Transthoracic Echocardiography to estimate the area of an orifice through which blood flows.Objectives : To compare simple PISA equation, created by combined fixing the angle to 1000 and the Val to 33 cm/s, with mitral valve area measured by pressure half time and planimetry which was taken as reference method.Patients and Methods : A cross sectional prospective study was conducted in multi teaching centers (Baghdad teaching hospital, Ibin AL Nafees hospital, Ibn AL Bitar hospital and Ghazi AL Harriry teaching hospital) from the June 2015 to the June 2016. 104 patients were enrolled in this study, 41 were excluded from the study (patients with mild mitral stenosis, with aortic regurgitation, mitral regurgitation and those with poor window were excluded from the study). Transthoracic echocardiographic examination include para sternal long axis, apical four chamber and parasternal short axis view were used to analyze parameters were selected by M - mode, 2D, and pulse doppler Results : There were 63 patients enrolled in this study with a mean age of 45.4 ± 7.1years, (23.8%) of them within the age group 30 - 39 years and the remaining (76.2%) were > 40 years. Female patients were the dominant represented 73.0% while male were 7.0% of the studied group (female : male ratio was 3 : 1); (61.9%) were in sinus rhythm and (38.1%) in atrial fibrillation. 58.7% of the patients are with Wilkin's score less than8, the mean mitral valve area according to planimetry method was (1.14 ± 0.32) cm2 and it was (1.12 ± 0.28) cm2 by PISA while the mean mitral valve area by pressure half time method was (1.19 ± 0.30) cm2. The agreement between PISA and planimetry revealed that PISA had good agreement with planimetry in diagnosis of mitral stenosis, (kappa= 0.835, P< 0.001). On the other hand, there was a fair significant agreement between pressure half time and planimetry.Conclusions : PISA method can effectively predict mitral valve area and severity of mitral stenosis by the equation; mitral valve area = 115 _ r2/Vmax, Provided that aliasing velocity is fixed at 33 cm/s, with the advantage of easy calculation over other methods used to evaluate mitral valve area by Trans thoracic Echocardiography.

علاقة هورمونات الغرلين, اللبتين, غلوكاغون والانسولين بمقاومة الانسولين بمرضى السمنة والناس الغير مصابين بالسمنة == Relationship between Ghrelin, Leptin, Glucagon and Insulin with Insulin Resistance in Obese Patients and Non - Obese Individuals

اسم المؤلف: دعاء مهدي عمران
اسم المشرف: علي حسين البياتي | سعد مرزة الاعرجي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: تعتبرالسمنة وباءا عالميا حيث انها تؤثرفي حوالي اكثر من 2 مليار شخص حول العالم حتى عام2013, ان ارتفاع نسبة انتشار السمنة في كل من البلدان المتقدمة والنامية كانت نتيجة لعدد من الاسباب والتي تتمثل بالبيئة، الوراثة الطبية مثل اضطراب الغدد الصماء، والعلاج مثل العقاقير المضادة للذهان والمنشطات الستيرويدية, ان اغلب الناس البدينين يكونون عرضة للاخطار الكبيرة حيث تعرضهم للمضاعفات كداء السكري وارتفاع ضغط الدم وتصلب الشرايين، ومشاكل المفاصل، وامراض السرطان وخاصة السرطانات المحفزة بالهرمون، بالاضافة الى مشاكل في الجهاز التنفسي وغيرها من المضاعفات الاخرى, ان الهدف من هذه الدراسة هو اظهار تاثير زيادة الوزن على تمثيل تاهورمونات التالية : الغرلين, اللبتين, الانسولين والغلوكاكون في المرضى المصابين بالسمنة مع او بدون مقاومة الانسولين ومقارنتهم بالناس الغير مصابين بالسمنة مع او بدون مقاومة الانسولين, تم اخذ 100 شخصا منهم 50 شخصا مصابين بالسمنة و50 شخصا غير مصابين للفترة بين شهر كانون الثاني 2015 وشهر حزيران 2016 بمعدل اعمار بلغ (34.00±9.43) بالنسبة لمرضى السمنة و(34.50±7.40) بالنسبة للاشخاص الغير مصابين بالسمنة, تم الاعتماد على معامل كتلة الجسم لتفريق المجموعتين وتم سؤال الجميع حول ان كانوا مصابين بامراض معينة او يتناولون ادوية معينة تؤثر في وزنهم, وتم مختبريا اجراء الفحوصات التالية : فحص نسبة السكر في الدم, هورمون الانسولين, هورمون الغلوكاكون, هورمون اللبتين, هورمون الغرلين وتم قياس مقاومة الانسولين حسب المعادلة بين الانسولين والسكرو اظهرت النتائج وجود فرق معنوي بين المجموعتين (p value ≤ 0.05) فيما يخص اختلاف الجنس والتعليم وكذلك اختلافا معنويا (p value ≤ 0.05) فيما يخص الفحوصات المختبرية لنسبة السكر في الدم, نسبة هورمون الانسولين, هورمون اللبتين ومقاومة الانسولين فيما لم تظهر فرقا فيما يخص هورموني الغرلين والكلوكاكون.اعتمد الباحث في تعريب المصطلحات العلمية على : المعجم الطبي الموحد - انكليزي - عربي. رئيس التحرير د. محمود الجليلي - الطبعة الرابعه 2009 م , مطبعة المجمع العلمي العراقي. | Obesity is representing a global epidemic that affecting more than 2 billion peoples around the world on 2013. The obesity prevalence has risen in both developed and developing countries. Many causes have been implicated for developing obesity such as : environmental, hereditary, medical disease like endocrine disorders furthermore, some medication like antipsychotic drugs and steroids. Obese people are at high risk to develop much complication such as diabetes, hypertension, atherosclerosis, joints problems, cancers especially hormone dependent, respiratory problems and others. The aim of this study was to compare the impact of increase in weight on the clinical presentation of Ghrelin, Leptin, Insulin, and Glucagon in obese patients with or without Insulin resistance and compare it to that of non - obese individuals with or without Insulin resistance, one hundred people are included in this study attending Marjan medical city from December 2015 till June 2016, a fifty normal non - obese and fifty obese, the overall mean age of patients and controls were (34.00±9.43) and (34.50±7.40) years old, respectively, they are classified according to body mass index after measuring their weight, height, the mean BMI of case patients was (39.23±6.71 kg/m²) and (23.08±1.19 kg/m²) for the control individuals, a general questionnaire were done for all patients and control for diagnosis excluded disease and any treatment that effect on obesity, the investigations that were done include : fasting blood sugar with hormonal testing is performed by ELISA kits examining Serum Insulin, Glucagon, Leptin and Ghrelin and the results of this study showed a significantly higher difference in percentage (p value ≤ 0.05) between study and control groups concerning education and gender. Regarding investigation there is significantly higher difference in percentage (p value ≤ 0.05) between study and control groups in parameters of fasting blood sugar, HOMA IR, Leptin and Insulin, while no significant difference (p value ˃ 0.05) in percentage between study and control for Ghrelin hormone and Glucagon hormone, so the conclusion of the results of this study support the evidence that obesity associated with Insulin Resistance, high level of Insulin and Leptin hormones and low concentrations of Ghrelin hormone, while it did not found a link with Glucagon hormone

دراسة بكتريولوجية وجزيئية لبكتريا Proteus mirabilis معزولة من عينات مختلفة == Bacteriological and Molecular Study of Proteus mirabilis Isolated from Different Clinical Samples

اسم المؤلف: ختام فاضل عباس
اسم المشرف: جواد كاظم الخفاجي | ميساء صالح الشكري
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: تلخصت هذه الدراسة بجمع وتشخيص P. mirabilis حيث عزلت وشخصت سبعة عشر عزلة (12.6%) عائدة الى بكتريا P. mirabilis من 135 عينة جمعت من مصادر مختلفة من المرضى المراجعين الى مستشفى الحلة الجراحي خلال الفترة من (تشرين الاول 2014 الى شباط 2015). عدد ونسبة العزلات التي تم الحصول عليها من مرضى المجاري البولية 11(64%)و التهاب الاذن 3(17%) . بالاضافة الى ذلك نسبة العزلات التي تم الحصول عليها من مرضى الاسهال والجروح والتهابات المهبل من كل حالة 1(5.9%). العزلات التي تم الحصول عليهزارعت في اوساط خاصة وشخصت بايوكيميائيا وبكتريولوجيا.من خلال التحري عن بعض عوامل الضراوة وجد ان جميع العزلات (100%) قادرة على انتاج الهيمولايسين ، اليورييز، البروتسين وظاهرة الانثيال. تم الكشف على انتاج البيتالاكتميزلجميع العزلات المقاومة لمضادات البيتا لاكتام بحسب طريقة Rapid Iodiometric وبينت نتائج الدراسة ان16(94.1%) من العزلات منتجة للبيتالاكتميز. اظهرت نتائج الدراسة قابلية جميع العزلات على مقاومة بعض المضادات الحياتية فقد بينت النتائج بان كل العزلات كانت مقاومة كليا 17(100%) الى Imipenem كما ان اغلب العزلات كانت حساسة الى Ertapenem حيث ان نسبة المقاومة فقط 3(17.6%). علاوة على ذلك مقاومة العزلات لمختلف المضادات الحياتية فحصت وظهرت ان العزلات مقاومة بنسب مختلفة 14(82.3%) منهم اعطت مقاومة الى Amoxicillin وCefotaxime , 9 (52.9%) منهم اعطت مقاومة الى Amoxiclave, 11(64.7 %) منهم اعطت مقاومة الى Ceftriaxone و4(23.5%) منهم اعطت مقاومة الى Cefepime Clavulanic acid.لجينات المشفرة عوامل الضراوة لبكتريا P. mirabilis كشفت باستخدام تقنية تفاعل البلمرة المتسلسل PCR)). ظهرت النتائج ان كل عزلات البكتريا اعطت نتيجة موجبة للجين rsbA, luxS, pm1, mrpA ,ureC مع عدد ونسبة ,(53%)9 7(41%), 8(47%),,(35%)6 ,(18%)3 بالتعاقب. | This study is devoted to isolation and identification of Proteus mirabilis; 17 isolates of P. mirabilis have been isolated and identified out of one hundred thirty five clinical specimens obtained from patients attending to Hilla teaching Hospital during a period from October 2014 to February 2015. The number and percentage of isolates obtained from patients with urinary tract infections was 11(64.7%), and ear infection 3(17.6%). Other isolates obtained from patients with diarrhea, wound and vaginal infection that each case has percentage 1(5.9%). The isolates obtained have been cultured in selective media and biochemically assay. Some virulence factors of all isolates are studied, and the results showed that all bacterial isolates 17(100%) produced hemolysin, urease, Bacteriocin (proticin) and swarming. The detection of β - lactamase production is performed according to Rapid Iodometric Method and the result is shown that 16(94.1%) of isolate produced beta - lactamase. Antibiogram of P. mirabilis isolates has been studied and it has been found that all isolates were entirely resistant to Imipenem 17(100%), while most of the P. mirabilis isolates were sensitive to Ertapenem so the resistant only 3(17.6%). Furthermore, the resistance of isolates to a variety of antibiotics has been investigated and found that these isolates have been resistant to more than one antibiotic : 14(82.3%) to Amoxicillin and Cefotaxime, also 9(52.9%) of them were resistant to Amoxiclave, 11(64.7%) of them were resistant to Ceftriaxone and 4(23.5%) of them were resistant to Cefepime Clavulanic acid. Virulence factors encoding genes of P. mirabilis is detected by using polymerase chain reaction PCR. It is found that all bacterial isolates gave positive result for ureC, mrpA, pm1, luxS and rsbA with number and percentage 3(18%), 6(35%), 7(41%), 8(47%), 9(53%) respectively

هرموني اللبتين والرزستين وعلاقتهما مع الجهد التاكسدي في مرض البقع المزمنة للصدفية == Correlation of Leptin and Resistin with Oxidative Stress in Chronic Plaque Psoriasis

اسم المؤلف: احمد محمد فاضل جواد المختار
اسم المشرف: عبد السميع حسن الطائي | محمد كاظم الحطاب
الموضوع العام: الطب
السنة: 2016
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: الصدفية هو مرض جلدي شائع يصيب 1 - 3 ٪ من سكان العالم ويتميز بالتهاب مزمن في خلايا بشرة الجلد مع تغيرات غير طبيعية في نضوج الخلايا الكيراتينية. تتراكم الادلة على دور السايتوكينات بما في ذلك الاديبوكينات مثل اللبتين والرزستين في التسبب بمرض الصدفية. ومن ناحية اخرى تتزايد الادلة على شمول الصدفية في الاجهاد التاكسدي نظرا لتعرض الجلد لاصناف الاوكسجين الفعالة، والتي تلعب دورا مهما في الاستجابات الالتهابية .الاهداف : تهدف الدراسة الحالية الى تقييم مستويات هرمونات اللبتين والرزستين، اضافة الى تقدير الاجهاد التاكسدي عن طريق قياس مستويات مضادات الاكسدة الكلوتاثايون والقدرة الكلية لمضادات الاكسدة وناتج اكسدة الدهون المالونيل ثنائي الالديهايد كمؤكسد في مرضى الصدفية ومجموعة من الاصحاء كمجموعة سيطرة في دراسة للحالات والشواهد. كما تهدف الدراسة الى التقصي عن العلاقة بين الاجهاد التاكسدي ومستويات اللبتين والرزستين فضلا عن دور هذه الاديبوكينات في توليد الاجهاد التاكسدي عند المرضى والاصحاء. المواد وطرق العمل : صممت هذه الدراسة كدراسة للحالات والشواهد. وشملت هذه الدراسة خمسين مريضا (30 ذكرا و20 انثى) مصابين بمرض الصدفية واربعين شخصا ( 20 ذكرا و20 انثى) اصحاء ظاهريا كمجموعة سيطرة بسن وجنس متوافقين. وكان متوسط العمر (45.47 ± 17.58) للذكور و(30.4 ± 19.33) للاناث لمرضى الصدفية ، وكان متوسط العمر لمجموعة السيطرة (46.35 ± 16.66) للذكور و(29.8 ± 12.25) للاناث. وقد اجريت هذه الدراسة في عيادة الامراض الجلدية في مستشفى مرجان التعليمي في مدينة الحلة، خلال الفترة من تشرين الثاني 2015 الى حزيران 2016. شخص مرضى الصدفية سريريا من قبل طبيب مختص. واجريت الاختبارات البدنية مثل مؤشر شدة مرض الصدفية ومؤشر كتلة الجسم بطرق منهجية.قدر هرموني اللبتين والرزستين بواسطة تقنية الفحص المناعي للانزيم المرتبط. وقدر الكلوتاثايون بوساطة تقنية كروماتوغرافيا السائل عالية الاداء، في حين تم تقدير القدرة الكلية لمضادات الاكسدة والمالونيل ثنائي الالديهايد بوساطة الطرق اللونية.النتائج : اظهرت نتائج الدراسة زيادة معنوية في مستويات هرموني اللبتين والرزستين والمالونيل ثنائي الالديهايد ، في حين اظهرت انخفاضا معنويا في مستويات الكلوتاثايون والقدرة الكلية لمضادات الاكسدة عند مرضى الصدفية بالمقارنة مع مجموعة السيطرة. لم يكن هناك ارتباطا معنويا بين الاديبوكينات اللبتين والرزستين مع مؤشر كتلة الجسم، بينما كان هناك ارتباطا معنويا موجبا مع مؤشر شدة مرض الصدفية. ووجدت علاقة معنوية سالبة بين الاديبوكينات ومضادات الاكسدة. في حين كانت العلاقة بين الاديبوكينات وناتج اكسدة الدهون المالونيل ثنائي الالديهايد علاقة معنوية موجبة. ووجدت ايضا العلاقات بين مؤشر شدة مرض الصدفية مع متغيرات الاجهاد التاكسدي كما هو الحال في علاقاته مع الاديبوكينات. الاستنتاجات : تقترح الدراسة الحالية شمول مرضى الصدفية بالاجهاد التاكسدي بوضوح من ملاحظة الانخفاض المعنوي في مستويات مضادات الاكسدة الكلوتاثايون والقدرة الكلية لمضادات الاكسدة والزيادة المعنوية في مستويات ناتج اكسدة الدهون المالونيل ثنائي الالديهايد، وكان ارتباط الاجهاد التاكسدي هذا ارتباطا معنويا مع شدة الصدفية.وجدت الدراسة ارتفاعا معنويا في مستويات هرموني اللبتين والرزستين في المرضى، وكان هذا الارتفاع يتناسب بشكل معنوي وطردي مع شدة مرض الصدفية. ووجدت الدراسة الحالية علاقة معنوية بين مستويات هرموني اللبتين والرزستين مع متغيرات الاجهاد التاكسدي، الامر الذي يدعم فكرة مساهمة اللبتين والرزستين في توليد الجذور الحرة والاجهاد التاكسدي في الصدفية. لذلك تقترح الدراسة ان هرموني اللبتين والرزستين قد يكونان السبب او قد يساهمان في توليد الاجهاد التاكسدي المرافق للصدفية وبعدة طرق | Psoriasis is a common skin disease affects 1 - 3% of the worldwide and is characterized by chronic inflammation of the skin epidermal cells with abnormal changes in the maturation of keratinocytes. There is accumulating evidence on the role of cytokines including adipokines such as leptin and resistin in the pathogenesis of psoriasis. On the other hand, increasing evidence was reported that psoriasis is involved in oxidative stress due to exposure of skin to reactive oxygen species, which play an important role in inflammatory responses. Objectives : The present study aims to evaluate the levels of leptin and resistin as well as, oxidative stress via measuring the levels of antioxidants, glutathione (GSH), total antioxidant capacity (TAC) and lipid peroxidation product malondialdehyde (MDA) as an oxidant in patients with psoriasis and healthy controls in case control study. The present study aims to investigate the relationship between oxidative stress and leptin and resistin levels as well as the role of these adipokines in the generation of oxidative stress in patients and healthy control.Subjects and Methods : This study was designed as a case control. Fifty patients (30 males, 20 females) with psoriasis and forty (20 males, 20 females) apparently healthy persons as control with the compatible age and sex were enrolled in this study. The mean age was (45.47±17.58) for males and (30.4±19.33) for females psoriatic patients, and the mean age for healthy control groups was (46.35±16.66) for males and (29.8±12.25) for females. The study was conducted in Dermatology Clinic of Merjan Teaching Hospital in Hilla City and Clinical Biochemistry Department in Babylon University College of Medicine during the period November 2015 to June 2016. Patients with psoriasis were diagnosis clinically by specialist physician. Physical examination like psoriasis area severity index PASI score and body mass index BMI were determined by systematic ways. Leptin and resistin adipokines were estimated by enzyme - linked immunoassay ELISA technique. GSH was estimated by high performance liquid chromatography HPLC, Whereas TAC and MDA were determined by spectrophotometic methods.Results : The results present in this study were shown as a significance increases in leptin and resistin levels as well as MDA, whereas significant decreases were found in the antioxidants levels GSH and TAC of psoriatic patients when compared with healthy control. There was no significance correlation between adipokines leptin and resistin with BMI, while there were significance positive correlations of adipokines with PASI score. The relations between adipokines and antioxidants found a significance negative correlations. Whereas, the relations between adipokines with lipid peroxidation end product MDA were significant positive correlations. Also, the disease severity as expressed by PASI score relation with oxidative stress parameters were found to be the same as that of adipokines correlations. Conclusions : The present study obviously suggested an involvement of the patients with psoriasis in oxidative stress by observing the significant decrease in TAC and GSH levels as well as the significant increase in levels of MDA, and this oxidative stress was significantly correlated with the severity of psoriasis. This study has found a significant elevation in levels of leptin and resistin in patients, and this elevation was significantly and directly proportional to the severity of the psoriasis. The current study has found a significant relationship among leptin and resistin levels with oxidative stress parameters, which supports the opinion of the contribution of leptin and resistin in the generation of free radicals and oxidative stress in psoriasis. Therefore, the present study suggested that the leptin and resistin may be the cause or may contribute in the generation of oxidative stress associated with psoriasis by many ways

مدى شيوع مرض السمنة والعوامل المرتبطة به بين طلبة جامعة ذي قار وكلية مزايا للعام الدراسي 2016 == Prevalence of Obesity and its associated factors Among Thi - Qar University and Mazaya college Students,2016

اسم المؤلف: Alaa Jassim Mohammod
اسم المشرف: Dheyaa k. Al - Omar
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: خلفية البحث : ان معدل انتشار السمنة يزداد في البلدان النامية ودول العلم الثالث .و السمنة هي احدى عوامل الخطر الرئيسية لعدد من الامراض المزمنة كالسكر وارتفاع ضغط الدم وامراض القلب ، ولذلك تعتبر من مشاكل الصحة العامة الرئيسية .الهدف : دراسة معدل انتشار السمنة والعوامل المرتبطة بها بين طلبة الجامعات في محافظة ذي قار . كذلك دراسة الانماط والعادات الغذائية بينهم.اشخاص وطريقة الدراسة : بدات هذه الدراسة المقطعية في الاول من نيسان وانتهت في العاشر من شهر ايار2016، تم من خلالها دراسة مجموعة تتكون من 841طالب وطالبة (358 و456 على التوالي ) بعمر 18 - 36 سنة (بمعدل7. 21 +2.3 سنة ) اختيروا بشكل عشوائي طلبة جامعة ذي قار الحكومية وكلية مزايا الاهلية . شملت استمارة الاستبيان معلومات عن العمر ،الجنس،عدد افراد الاسرة ،الدخل الشهري للاسرة ،المستوى التعليمي للابوين ،السكن ،عدد ساعات النوم خلال اليوم ، وسيلة المجيئ للكلية ،نوع النشاط الممارس اثناء اوقات الفراغ ،العادات الغذائية وقائمة تحتوي انواع مختلفة من الاطعمة ، تم قياس الوزن ،الطول ،محيط الخصر، ودليل كتلة الجسم لتقييم الحالة التغذوية . تم تحليل البيانات باستعمال الرزمة الاحصائية للعلوم الاجتماعية (اس بي اس اس )النسخة 23 اعتبرت قيمة p اصغر من 0.05 ذات قيمة معنوية احصائيا .النتائج : كان معدل كتلة الجسم للطلبة24.17+4.0 كغم /م 2 وكان اكثر من نصفهم من (59.2) من ذوي الوزن الطبيعي (63.8 %من الطلاب و55.2 %من الطالبات ) ، بينما كان معدل انتشار زيادة الوزن وكذلك السمنة بينهم 28.3 % و8.1 % على التوالي . كان معدل انتشار السمنة متقاربا بين الذكور والاناث ، بينما كان معدل انتشار زيادة الوزن اكثر شيوعا بين الطالبات مقارنة بالطلاب (32 %مقابل 23.1 % على التوالي ).كان معدل انتشار قلة الوزن اكثر شيوعا بين الطلاب مقارنة بالطالبات (5.1 %من الطلاب مقابل 3.7 % من الطالبات ) .اعتمادا على محيط الخصر كان 3 % من الذكور و18 % من الاناث اكثر عرضة لخطر الاصابة بالامراض المصاحبة للسمنة .كان معدل انتشار السمنة ومحيط الخصر اعلى لدى الطلبة الذين تتجاوز اعمارهم السادسة والعشرين وكذلك الطلبة من ذوي الاسر التي لاتتجاوز اعداد افرادها الست اشخاص(p<.05) لكلا المتغيرين . نسبيا ، هناك نسبة عالية نسبيا (42.7 %من الطلاب و35.8 % من الطالبات )يقضون اكثر من ساعتين في اليوم امام شاشات الحاسوب . الطالبات اقل نشاطا وحركة من الطلاب (p<.05) نسبة عالية من الطلاب والطالبات لا يتناولون وجبة الافطار والحليب وكذلك الخضروات والفواكه يوميا .الاستنتاجات : تدعم هذه الدراسة بانه هناك عوامل متعددة مسببة للسمنة . واظهرت ان العمر والاسر المكونة من اقل من ستة اشخاص من عوامل الخطر . | Background : The prevalence of overweight and obesity is increasing in both developed and developing countries. Obesity is a major risk factor for many chronic diseases including diabetes, hypertension and ischemic heart diseases, so it is considered a major Public health problem. Objectives : to study the prevalence of obesity and its associated factors among Thi - Qar university students. Dietary habit and food consumption pattern are also assessed.Subjects and methods : A cross sectional study started from 1st of April 2016 - 10th of May 2016, A total of 841 students (358 were males and 456 were females) between 18 years and 36 years of age (mean 21.7 ± 2.3years) were selected randomly from 24 colleges of both Thi - Qar and Mazaya private college. A questionnaire was distributed to each participant : Age, gender, family member numbers, monthly family income, level of parent educations, residency, time of sleep per night, types of activity during leisure times, dietary habit and different food items were considered, Height, weight and waist circumference were measured and BMI was calculated and used to assess weight status. The data were analyzed by using SPSS. p value less than 0.05 was considered as statistically significant.Results : The mean BMI was 24.17 ± 4.0 kg/m2; more than half (59.2%) of students were of normal weight (63.8% of male students and 55.2% of female students); whereas the prevalence of overweight and that of obesity among them was 28.3% and 8.1% respectively. The prevalence of obesity was nearly similar for both male and female students, while the prevalence of overweight was more common among female’s students than among males (32 %of females vs. 23.1% of males). The prevalence of underweight was more common among male than female students (5.1 % of male vs. 3.7 % of female). Depending on their waist circumference 3% of male and 18 % of female students were at a higher risk of developing abdominal obesity co morbidities. There was a significant higher prevalence of obesity and mean waist circumference within students of more than 26 years old aged and of less than 6 household family number (p < .05 for both variables).A relatively high proportion (42.7 % for males and 35.8 % for females) spend more than two hours on screen time daily. Females were significantly (p< .05) much less physically active than males. A high proportion of students (male and female) didn’t have a daily intake of breakfast, milk vegetable or fruitConclusion : The prevalence of obesity and overweight were more than the obesity reported among university students in previous local studies in Iraq, however it still lower than obesity and overweight reported among the university students of the neighborhood countries. The study supports the multi factorial etiology of obesity; it demonstrates that age, parent’s education and household number are risk factors. The study also shows high prevalence of sedentary behaviors, physical inactivity and unhealthy dietary habit among Thi - Qar university students.Recommendation : the study results mandate the need for public health strategies to prevent overweight and obesity and adopt a healthy dietary habit and life style.Key word : Prevalence, Obesity, Overweight, Cross sectional study, Dietary habit, Life style.Abbreviations : WHO, World Health Organization; BMI, body mass index; SPSS, Statistical Package for Social Sciences.

مدى انتشار الامراض غير الانتقالية بين الناس المسنين في مدينة الناصرية 2015 : دراسة مسحية سكانية == Prevalence and patterns of non - communicable diseases among a geriatric population in Al - Nasiriya city 2015

اسم المؤلف: رحيم نايف ناصر
اسم المشرف: علي عبد سعدون الغزي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: دراسة مدى انتشارالامراض المزمنة غير الانتقالية بين الناس المسنين في مدينة الناصرية وتقييم الوضع الصحي العام لهم وتقييم خدمات الرعاية الصحية المقدمة لهذه الفئة من السكان.المواد والاساليب : دراسة مقطعية وصفية وتحليلية من خلال اجراء المسح السكاني للعوائل في بعض الاحياء السكنية. اجريت هذه الدراسة في منطقة حضرية جغرافيا من مدينة الناصرية التي تبعد عن العاصمة بغداد 360 كم جنوبا. تمت الدراسة خلال فترة امتدت اكثر من سنة (من 1 ايلول 2015 الى نهاية شهر تشرين الاول 2016). تم جمع البيانات من عينة تمثيلية من 423 من الاشخاص الذين تتراوح اعمارهم من 60 سنة فما فوق ومن خلال اخذ عينات متعددة المراحل (عنقودية).النتائج : كان معدل انتشار الامراض المزمنة غير الانتقالية بنسبة 89.8% بين الاشخاص المسنين، وفي مقدمتها الحالات الخمسة التالية : ارتفاع ضغط الدم (67%)، مرض السكري (31,2%)، امراض العظام والعضلات (15,4%)، امراض القلب (11,1%)، اعتام عدسة العين (12,8%) وكان انتشار مرضين او اكثر في ان واحد بمعدل 59%.اما اعراض ومشاكل الشيخوخة الرئيسية فكانت : مشاكل في الرؤيا (77,8%), الشعور بالحزن او الاكتئاب (36,4%)، مشاكل السمع (31,7%)، السقوط (30%), مشاكل في الذاكرة (22,9%)، والاعراض البولية (11,1%).اثبتت هذه الدراسة ان معدل انتشار الامراض المزمنة غير الانتقالية في مدينة الناصرية كان مرتفعا ومثيرا للقلق وخاصة امراض القلب والاوعية الدموية التي تحتاج الى الجهود الفعلية والتركيز في مجال الوقاية وكذلك تحسين وتعزيز نظام الرعاية الصحية خاصة في مجال الرعاية الصحية لكبار السن للحد من الاصابة بالامراض المزمنة ومضاعفاتها والاثر السلبي على الحياة والتطور الاقتصادي | More than one year starting from the 1st September 2015 to the end of October 2016, an observational, analytical - cross - sectional study through a household survey was conducted in Al - Nasiriya city to study the prevalence of non - communicable diseases among a geriatric population, other objectives were to describe the symptomatology (geriatric review of system for elderly), subjective general health status of wellbeing, and the accessibility and satisfaction of patients to health care services provided in this segment of the population. A representative sample of 423 individual aged ≥ 60 years through multistage sampling had been included in the study. Special form of questionnaire was planned to collect information, which tested by three experts in the field of community medicine and family medicine for the validity before its use in the collection of data. The diagnosis of cases (the inclusion and exclusion criteria) was clearly depending on the chronic disease card or any available documentations that support the definite diagnosis (medical reports, investigation, or current treatment). In contrast to self - reporting studies, the direct observation from the researcher as an advantage of a cross - sectional household survey study plays an important role in minimizing the information bias during the stage of data collection. In addition, it was based mainly on the doctors - diagnoses conditions and consistent with the definition of chronic diseases A pilot study was conducted on 18 elderly individuals prior to the proper study in order to test the feasibility of the research, time requirement and the cost. The results were discussed with the supervisor for any change or modification needed. All those 18 cases were included in the proper study. For statistical analysis, Statistical Package for Social Sciences (SPSS)version (23) was used for data analysis including frequencies, percentages, test of significance (Chi - square test, Monte Carlo test, Fisher exact test), correlation and logistic regression analysis. A p - value of <0.05 was considered to be significant. The overall prevalence of at least one chronic NCD was 89.8%. The top five chronic conditions : hypertension (67.8%), diabetes mellitus (31.2%), musculoskeletal diseases (15.4%), heart diseases (11.1%), and cataract (12.8%). The prevalence of multi - morbidity (patient with two or more chronic diseases) was 59%. The main geriatric symptoms were vision related problems (77.8%), feeling sad or depressed (36.4%), hearing problems (31.7%), falls (30%), memory problems (22.9%), and urinary symptoms (11.1%). The main limitations in this study were its performance in an urban area, some cautions must be taken regarding the generalization of the results. Also not all types of chronic disease and geriatric symptoms were discussed in this study, however all the available data in the sample were collected and studied. Nevertheless, further studies are required specially to estimate the prevalence of risk factors, to estimate the cost of care and health, expenditure, quality of health services and geriatric health need. This study will help in establishing the priorities to act on according to the magnitude of the problems and their impact. Also to design the strategies for prevention and control of NCDs. According to the results obtained from this study and the current situation regarding the care of geriatric population in Iraq and specifically in Al - Nasiriya city, the most important and practical recommendation is to activate the geriatric health care at PHCCs or at least in every hospital with a geriatric clinic with well - trained doctors and other heath staff in the field of geriatrics.

الاستدلال عن مستقبلات الاستروجين ، البروجستيرون وعامل النمو البشري لدى مرضى سرطان الثدي في الناصرية2014 - 2015 == Expression of Estrogen, Progesterone and Human epidermal growth factor Receptors in Breast Cancer in Al - Nasiriya 2014 - 2015

اسم المؤلف: اصيل ضيول حسن
اسم المشرف: حميد نعيم موسى
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: الخلفية : سرطان الثدي هو الورم الخبيث الاكثر شيوعا ومشكلة الصحة العامة للسيدات في جميع انحاء العالم وفي العراق. سرطان الثدي هو مرض متغير الخواص للغاية، هناك ثلاث علامات تنبؤيه : مستقبلات الاستروجين، مستقبلات بروجسترون ومستقبلات عامل النمو عندها قيمة تنبؤيه مستقلة. يظهر تعبيرERفي 80 - 90% من المرضى بسرطان الثدي، بينما يظهر تعبيرPRفي 70 - 80 % من الحالات. مستقبلات عامل النمو موجود في 15 - 20% من الحالات. لهذاسرطان الثدي يمثل بشكل افضل بتعبير المستقبل المشترك من التمثيل بمستقبل واحد 0علامات الواسم المناعي - الكيميائي النسيجي (IHC) من مستقبلات هرمون الاستروجين (ER)،مستقبلات هرمون البروجسترون (العلاقات العامة) ومستقبلات عامل النمو (HER2) يمكن تصنيف التعبير الهرموني لسرطان الثدي الى 4 انواع فرعية : النوع الاول ثلاثي موجب مستقبلات الهرمونات(هرمون الاستروجين موجب والعلاقات العامة موجب ومستقبلات عامل النمو موجب)؛النوع الثاني (هرمون الاستروجين موجب والعلاقات العامة موجب ومستقبلات عامل النمو سالب)؛ النوع الثالث ثلاثي سالب مستقبلات الهرمونات (هرمون الاستروجين سالب والعلاقات العامة سالب ومستقبلات عامل النمو سالب)والنوع الرابع (هرمون الاستروجين سالب والعلاقات العامة سالب ومستقبلات عامل النمو موجب).الدراسات السابقة اظهرت ادلة على الفرق الجزيئية التي تكون مسؤولة عن الفرق النتيجة0الهدف من الدراسة : هو تقييم حالة الهرمونات وعلاقتهم بدرجة ومرحلة الورم لحظة تشخيص المرض0المرضى وطريقة العمل : كان نوع الدراسة دراسة مقطعية في محافظة ذي قارفي مدينة الناصرية في مستشفى الحبوبي مركز الاورام ،تضمنت 165 حالة من المرضى الذين شخصت اصابتهم بسرطان الثدي خلال فترة (كانون الثاني 2014 - كانون الاول 2015) تم تجميع معلومات كل مريض وتحليلها : عمر المريض ،الجنس، مكان الاقامة ومعلومات متعلقة بالورم مثل درجة الورم ومرحلة الورم، ومنزلة المستقبلات (ER،PR،her2مستقبلات)0النتائج : العمري الوسطي = 49 ± 11.1. وكانت معظم الحالات 75,2% هرمون البروجسترون موجب بينما هرمون الاستروجين موجب في (72.7٪)،ولكن معظمهم كانواHER2سالب(78.2٪). كان معظم المرضى من الدرجة الثانية (64.2 ٪ ) والمرحلة الثانية (50.3 ٪ )؛كان النوع الفرعي الاكثر شيوعا (ER / PR موجب وher2سالب )والتي تمثل 64.8٪ 0بالنسبة لمقارنة التعبير الهرموني للمرض مع درجة ومرحلة الورم لوحظ ان اعلى درجة الورم (الثاني) (76.93٪) وجدت في النوع الرابع (ER / PRسالب،HER2موجب) وكانت هناك علاقة بين التعبير الهرموني ومرحلة المرض0 الاستنتاجات : سرطان الثدي يمتلك خصوصية مستقبلات هرمونية0الكثير من الحالات توجد في المرحلة الثانية والدرجة الثانية لحظة التشخيص0 التعبير الهرموني السلبي متعلق بمرحلة متقدمة من المرض 0ينبغي توجيه الجهود في توحيد اساليب وتطوير اختبارات اكثر وثوقا لتشخيص المرض بمرحلة مبكرة0

Epidemiology of Acute Childhood and Adolescent Poisoning in Al - Nassiryia Poison Center (2013 - 2015)

اسم المؤلف: Khashaa Abdulkadhum Jaber
اسم المشرف: Raid Kareem Dehiol
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: Background : Acute childhood and adolescent poisoning remain one of the important emergencies causing a significant burden to the populations with important morbidity and mortality rates. Epidemiological studies are so important to determine the extent of the problem, according to which the preventive strategies are related. Objectives : This study aimed to determine the epidemiological features of poisoning for the patients less than 19 years old in Thi - qar governorate, involving the main types, clinical presentations, management, outcome, and seasonal variation of poisoning. Methods : A descriptive cross sectional study was involved 340 patients recorded in Al - Nasiriyah poison center from (January 2013 to December 2015), data that collected from the case sheets and records of phone cases. These data was analysed by the statistical package of social science (SPSS) for analysis. Results : Toddler age group seen in 45% of cases with predominance of accidental type, while adolescents (14 - 18yrs.) are mostly intentional with female preponderance, two hundred cases (58.8%) of the exposed patients were male, urban populations are more prone to poisoning 236 cases (69.4%), accidental exposure is the commonest (83.2%), oral route is (99.4%), (62.9%) of the causative agents are pharmaceutical, and (50.7%) are asymptomatic. most of them treated conservatively (96.5%) with survival rate of (97.9%), mortality seen in those presented after the first 24 hrs. of exposure. One third of acute poisoning occurred in summer season.Conclusion : Toddler age group commonly prone to acute poisoning, male are more in accidental pattern, majority of patients were from urban population, one third of the poisoning occur at summer, and there is a strong relationship between time of arrival to the hospital and outcome of the patient

نسبة انتشار اضطراب الكابة بين النساء الحوامل اللواتي يعانين من التقيؤ الحملي الشديد في مستشفيات ذي قار للامومة == Prevalence of depression among pregnant women with hyperemesis gravidarum in Thi - Qar maternity hospitals

اسم المؤلف: منار نجم عبد
اسم المشرف: Alaa Hussein Ali Al Nasir
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الطب النفسي
الجامعة: جامعة ذي قار
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: خلفية : على الصعيد العالمي، يعتبر مرض الاكتئاب السبب الرئيسي الاول للعبيء المرضي بين النساء في سن الانجاب (14 - 45سنة). اما على الصعيد الوطني، فان المعلومات المنشورة حول انتشار الاكتئاب في النساء الحوامل الذين يعانون من التقيؤ الحملي الشديد هي معلومات شحيحة .الاهداف : تم اجراء هذه الدراسة لقياس مدى انتشار الاكتئاب بين النساء الحوامل اللواتي يعانين من التقيؤ الحملي الشديد في مستشفيات ذي قار للامومة.الطرائق : تعتبر هذه الدراسة دراسة مقطعية منفذة في اثنين من المستشفيات التعليمية لمحافظة ذي قار ( مستشفى الحبوبي التعليمي ومستشفى بنت الهدى التعليمي) للفترة ما بين الاول من شهر ايلول 2015 ولغاية الواحد والثلاثون من شهر تموز 2016. جميع النساء الحوامل اللواتي يعانين من التقيؤ الحملي الشديد واللواتي راجعن العيادات الخارجية لاقسام النسائية في هذه المستشفيات , تم تضمينها في هذه الدراسة. تم احتساب العينة البحثية بناء على نسبة انتشار الاكتئاب بين النساء الحوامل في دراسة سابقة في العراق (37.2٪)، وبنسبة دقة انتشار 5% ومستوى ثقة 95%, وبعد اضافة 10% لتغطية استمارات التحري الناقصة والنساء الحوامل الرافضات للاشتراك في هذا البحث, يكون حجم العينة البحثية (322) مشاركة .تم جمع البيانات بواسطة استمارتي استبيان, الاولى النسخة العربية من مقياس بيك للاكتئاب - II والثانية صممت خصيصا لغرض هذه الدراسة. النساء الحوامل المشاركات في البحث واللواتي يجمعن نقاط تقييم استمارة النسخة العربية لمقياس بيك - II اكثر من (20) نقطة, تعتبر المشاركة مصابة بالاكتئاب. النتائج : تبين هذه الدراسة ان معدل انتشار الاكتئاب بين النساء الحوامل اللواتي يعانين من التقيؤ الحملي الشديد في مستشفيات ذي قار للامومة هو 37.1٪. يتاثر هذا المعدل بشكل كبير بزيادة العمر الحملي "Increased gestational age" (P = 0.003)، الوضع الاجتماعي والاقتصادي المرتفع "High socioeconomic status" (P = 0.009)، التاريخ السابق للاصابة بالتقيؤ الحملي"previous history of Hyperemesis gravidarum" (P = 0.03)، الحمل غير المرغوب فيه "Unwanted pregnancy" (P = 0.03)، وزيادة عدد مرات الحمل "Gravidity" (P = 0.03) .الاستنتاجات والتوصيات : ثلث النساء الحوامل اللواتي يعانين من التقيؤ الحملي الشديد في مستشفيات ذي قار للامومة يعانين من الاكتئاب. عليه يوصى باعادة فرض برامج الرعاية الصحية النفسية للنساء الحوامل من خلال خدمات الرعاية الصحية الاولية السابقة للولادة في مستوى الرعاية الصحية الاولية، مع تعزيز اساليب اعادة التاهيل النفسي والاجتماعي التي تستخدم لتاهيل النساء الحوامل المصابات بالاكتئاب | Background : Globally, depression is considered as the first leading cause of disease burden in women at child bearing age (15 - 44year). Nationally, scarce information was published regarding the prevalence of depression in pregnant women with hyperemesis gravidarum.Objectives : This study was carried out to measure the prevalence of depression among pregnant women with hyperemesis gravidarum in Thi - Qar maternity hospitals.Materials and methods : A hospital based cross sectional study was carried out in two teaching hospitals (Al Habobi teaching hospital and Bent Al Huda teaching hospital) in Thi - Qar Maternity hospitals from first of Sep/2015 to 31st of Jul/ 2016. All pregnant women who were suffering from hyperemesis gravidarum, and attended the obstetric outpatients in these two hospitals were included in this study. Based on assumed prevalence of depressive symptoms among pregnant women in a previous study in Iraq was (37.2%), so the needed sample size to calculate such prevalence rate with precision of 5%, confidence level of 95%, and added extra sample of 10%, is almost equal to 322. Women data were collected by using Arabic version of Beck depression inventory - II and a specialized questionnaire which was designed for the purpose of the study. Depression was considered when patients have BDI - II score of > 20. Results : This study showed that prevalence rate of depression among pregnant women with hyperemesis gravidarum was 37.1%. This rate was significantly affected by increased gestational age (P = 0.003), high socioeconomic status (P = 0.009), previous history of hyperemesis (P = 0.03), unwanted pregnancy (P = 0.03), and increased gravidity (P = 0.03).Conclusion : One - third of pregnant women with hyperemesis gravidarum in Thi - Qar maternity hospitals had depression. It is recommended to re - inforce mental health care of pregnant women through the antenatal care services at primary health care level, with strengthening the mental and social rehabilitation methods that are used for diagnosed women with depression. Key word : Depression, pregnant, hyperemesis gravidarum, Thi - Qar province

تقويم تحمل بعض اصناف البطاطا Solanum tuberosum L للملوحة خارج الجسم الحي == Evaluation of certain potato (Solanum tuberosum L.) cultivars for salinity tolerance in vitro

اسم المؤلف: اماني اسماعيل خليل طاهر
اسم المشرف: ماجد عبد الحميد ابراهيم | عواطف نعمة جري
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات - البستنة
الدرجة: دكتوراه
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: The study was carried out at the laboratory of plant tissue culture - college of Agriculture - University of Basra during the period 15/3/2013to 20/07/2015 ,to study the effect of salinity stress on some growthindicators contain in callus produced from three potato varieties (Lizeta,Arnova and Safari) in Vitro.The sprout of the three potato varieties (Lizeta, Arnova and Safari) were cultured in aseptic condition on Murashige and Skoog (MS) full strength media supplemented with IAA and BA at concentration of 1.0 mg / L in addition to GA3 at concentration of 0.1 mg / L.For callus induction, the shoots were cultured on (MS) media upplemented with 3 mg / L NAA in combination with 1 mg / L Kin or BA.Moreover; to study the effect of salinity stress on some growth indicators , the callus exposed to NaCl at concentration (0,80, 100, 120 ,140 and 160 mM ) four weeks period, in additon to the effect of salisalic acid in combination with NaCl on protien charectirstic in callus of three potato cultivars. The results sammurized at follow : 1 - The effect of cultivars and growth regulators results sammaurized : No significant on regeneriation ,but Arnova cultivar was superior in height plant and number of shoots reached (7.27 cm and 2.48 shoot ) respectively.Lizeta was superior in number of leaves (1.59 leaves / plant ), the combination of hormons (1.0 mg/L of eachIAA & BA) was superior in height plant and number of shoots reached (2.1 cm and 1.6 leaves / plant ) respectively. 2 - Lizeta cultivar was superior in (% callus induction, callus fresh weight on 28 and 45 days ,CHO,protein,proline, Lipid peroxidation and K+ ion) parameters reached (31% ,186.25 mg, 303.9 mg, 29.09 mg /gm dry weight , 16.29 mg/gm dry weight 3.05 μ.gm /dry weight , 204 nmol MDA g/ fw and 9.16 mg/gm dry weight ) respectively .While Ornova cultivar was superior in (plant hight,shoots number, callus dry weight ) reached (7.27 cm, 2.48 shoot/ plant and 18.13 mg) respectively .3 - The combination of (1.0 mg / l ) of BA and IAA affected significantly on number of shoots and leaves parameters and give (2.1 shoot/plant ,1.61 leaf/ plant ) respectivelywhile (1.0 mg/l IAA+0.1 mg/l GA3 +1.0 mg/l BA ) affected significantly on shoots hieght which reached 8.03 cm .4 - Varied response were found among potato callus growth under 100 mM concentration of salt stress, Arnova and Lizeta were superior as compare with Safari which didn’t show any response in addition to callus growth reduction were found at high concentration (120, 140 and 160 ) mM of salinity . Moreover,100 mM gave negative responce on on callus fresh and dry weight .Furthermore, NaCl affected significantly on V.C and Lipid peroxidation at high concentration of NaCl as compare to control treatment .Concerninig to (CHO,protien,proline, Na - 1 and Cl - 1 ions containt ) , 100 mM of NaCl gave posetive responce for both Lizeta and Arnova cultivars as compere to Safari which in turn recorded highest rate at 80 mM concentration and less concentration of protien , K and K/Na ratio 5 - the interaction of 120 mM NaCl with 0.250 mM SA affected significantly on callus growth in Lizeta as compare with other tow cultivars which recorded no responce NaCl affected posetively on Gen expression, in callus of potatocultivars which represented in a form of a new protein bands with new molecular weight at 80 and 100 mM in addition to the interaction of NaCl with SA treatment in Lizeta cultivar. 7 - Significant responce were found among NaCl and potato cultivars in % of shoot initiation reached 42.11% for Lizita in control treatment and less responce in 80 mM reached 11.78 %. 8 - Sucsessful % of acclimatized plant for Safari reached 82.59% as compare to other cultivars while Lizita was superior in plant hight number of leaves, total root system length ,total yield , number and dimeter of tubers reached (28.33cm, 5.50 leaf/plant ,1.06 dcm2 ,10.25 cm, 17.63 g/plant , 5.16 tuber/plant, 3.18 cm) respectively . On the other hand Safari cultivar were recorded significant reduction in proline, CHO, protien reached (2.03 μ.gm/dry weight, 23.05 and 5.77 mg/gm dry weight) respectively.

دراسة تاثير طرق الاستخلاص على مكونات الزيوت العطرية لبعض بذور العائلة الخيمية باستخدام تقنية GC - - MS

اسم المؤلف: رفل عبد الحسين رسن المالكي
اسم المشرف: ضياء فالح عبد الله الفكيكي | اسعد رحمان سعيد الحلفي
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الاغذية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: In this study, essential oils extracted from Umbelifera family plants (cumin, aniseed, fennel, and caraway) have been extracted by using microwave - assisted water distillation and traditional water distillation (Clevenger method).The results showed that the needed time to extract essential oils from seed by microwave - assisted water distillation was significantly less than Clevenger method. The results also showed that the higher oil yield extracted from cumin, aniseed, fennel, and caraway by microwave - assisted water distillation were 4.8, 1.3,7, 3.4 and 2.8 % respectively, while by using Clevenger method were 4.5, 2.8, 2.3 and 1.3 % respectively. As noticed that higher oil yield was from cumin compare with other studied oils.Physical properties have been studied of extracted oils by microwaveassisted water distillation and Clevenger method. The results revealed that oils extracted by the two methods were dissolved into alcohol and did not dissolve in water. Also, colors of extracted essential oils ranged between yellow to yellowish brown. Caraway oil was yellow gold, cumin was yellowish. In addition, the taste of fennel oil and aniseed was sweet contrary to cumin and caraway oils were bitter. Specific density of all essential oils extracted by microwave - assisted water distillation and Clevenger method in this study ranged from 0.64 - 0.92. Refractive index values of extracted essential oils by Clevenger ranged between 1.48 - 1.55, and 1.49 - 1.55 by microwave - assisted water distillation. In terms ofabsorbency, the better absorbency was at microwave - assisted water distillation and Clevenger method at wave length of 280 nm compare with other oils that appeared better absorbency at wavelength of 250nm. Antioxidant activity has been measured of different concentrations of the four essential oils extracted by microwave - assisted water distillation and Clevenger method. Also, the results showed that antioxidant activity of linoleic acid of essential oils was converging for both methods Antioxidant activity was increased with increasing essential oil concentration, and the concentration of 100% had gave higher value of antioxidant activity of oils extracted from cumin, aniseed, fennel, and caraway by Clevenger reached 60 ، 69،78%respectively, also reached 65, 74, 59, 68% respectively for essential oils extracted by microwave - assisted water distillation . Also, the results showed that antioxidant activity of caraway oil was significantly higher than other essential oils. The abilityof different concentration from the four essential oils extracted by microwave - assisted water distillation and Clevenger method has been studied in the growth inactivation some types of pathogenic bacteria such as Escherichia coli, Pseudomonas aeroginosa and Staphylococcus aureus where noticed that activity of essential oils was increased with increasing oil concentration and the higher inactivation of oils was at 100% concentration. There is a variation in activity of all essential oils toward Bactria types. Caraway has high inactivated effect compared with other oils in this study and inactivation diameter of oil caraway extracted by Clevenger at concentration of 100% reached 19, 28, 32 mm toward testing Bactria of Staphylococcus aureus، Escherichia coli and Pseudomonas aeruginosarespectively, while average inactivation of this oil extracted by microwave - assisted water distillation was less compare with Clevenger where reached 30, 25, 16 mm towards cited Bactria types respectively. The results also showed that the identification of activation chemical compounds that is present in the essential oils xtracted by Clevenger and microwave - assisted water distillation using GC - MS technique for acknowledgment its quality, quantity and percentage in the four essential oils as follow : 1. The results of identification of active compounds of essential oil caraway extracted by Clevenger and microwave - assisted water distillation have been demonstrated Carvon compound by high ratio reached 47.12 and 40.5 % for both extraction methods respectively, while compound ratio Anethol and D - Limonene of caraway oil extracted by Clevenger were 16.18 % and 11.67% respectively and by microwave - assisted water distillation were 22.19% and 10.96% respectively.2. The chemical compounds like Alpha - Isopropylbenzyl alcohol, Cumic aldehyde and betapinene extracted from cumin essential oil by Clevenger reached 35.19, 22.60 and 13.26% respectively, while reached 33.77, 21.24 and 13.26% respectively by using microwaveassisted water distillation. On the other hand, the compound of Alpha - Isopropylbenzylalcohol has higher concentration compared with other prevailing compounds in extracted oil by these two methods.3. The results showed that the appearance of chemical compounds in aniseed oil extracted by Clevenger and the higher ratio was registered by Anethol compound reached 75.33% compared with other prevailing compounds, also the appearance of the samecompound with high ratio reached 77.58% in the extracted oil by microwave - assisted water distillation.4. The prevailing compounds in the essential oil of fennel extracted by clevengerwere Anethol , L - Fenchon and Estrago by 72.78, 7.41 and 5.52% respectively, while their ratio reached 67.01, 8.28 and 4.93% respectively by using microwave - assisted water distillation.From these results, the Anethol compound was prevailingcompound in the two extraction methods.

مقارنة عيوشية المعززات الحيوية في منتجات الالبان المحلية ودراسة تاثيرها على بعض المعايير الدموية لفئران التجارب == Compared to the viability of bio - boosters in the local dairy products and the study of its impact on some of the blood standards for mice

اسم المؤلف: زينب مصدق جعفر الشلاه
اسم المشرف: حيدر ابراهيم علي | سرمد غازي الشاوي
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الاغذية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:

تاثير نظام الزراعة واضافة السماد Moench النتروجيني في نمو وحاصل محصولي الذرة البيضاء .Vigna radiata L والماش (.L) Sorghum bicolor == Effect of planting system and Nitrogen fertilizer application on growth and yield of Sorghum (Sorghum bicolor (L). Moench) and Mungbean (Vigna radiate L.)

اسم المؤلف: ياسين محسن غضيب البهادلي
اسم المشرف: علي فرهود ناصر
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات - المحاصيل الحقلية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: Field experiment executed during 2015 season in farmers' fields in the AL - Maymonh district southwest of Missan province ( about 30 km from city center) in Silty loam soil. The objective of the study was to know the effect of intercropping system and nitrogen fertilizer on growth and yield of Sorghum and Mungbean, The experiment executed in split - plot in (R.C.B.D) design with three replicates, main plot were include nitrogen fertilizer with four levels (F1=50 , F2=100, F3= 150, F4=200) Kg N ha - 1. While sub plot were include three planting systems (Sorghum only= S1, Mungbean only=S2, one line of Sorghum + one line of Mungbean= S3). Variety kafer of Sorghum and local variety of Mungbean was used. The experiment include 36 experimental units, area of each units (3and studying the following characteristics : Plant height(cm),the number of leaves ,leaf area(cm2),leaf area index for two crops, number of grain in panicle and 1000 grain weight(gm) of sorghum ,number of pod.plant - 1, number of seed.pod - 1 and 1000 seed weight (gm) of Mungbean ,biological yield (t ha - 1) ,total economic yield (t ha - 1),harvest index (%) ,protein percentage (%) for two crops. Results were analyses statistically and mean compared with LSD test, the result of the study showed the following : 1 - Single plant pattern caused significant increasing on plant height of Sorghum and Mungbean, number of leaves; leaf area; leaf area index; number of grain in panicle;number of pod in plant; number of seed in pod; weight of 1000 grain or seed for Sorghum and Mungbean; biological yield of Mungbean; seed yield of Mungbean 1.79 t ha - 1; highest protein percentage of Mungbean. Single planting pattern non - significant in Sorghum biological yield; harvest index of Mungbean. Intercropping pattern caused significant increase in protein percentage of Sorghum and non - significant increase grain yield of Sorghum that gave 4.58 t ha - 1 compared with single plant pattern that gave 4.57 t ha - 1.2 - Increasing N rate increased almost studied characteristics , level of 200 kg N ha - 1 gave highest average of plant height of Sorghum and Mungbean; number of Sorghum leaves; leaf area , leaf area index, biological yield of Sorghum and Mungbean; number of grain in panicle; number of seed in pod; number of pod in plant; highest grain yield of Sorghum 6.50 tha - 1; highest seed yield of Mungbean 2.60 th - 1 and highest harvest index for Sorghum and Mungbean, Application 150 kg N ha - 1 significantly increased protein percentage and gave highest average of Sorghum and Mungbean Application nitrogen fertilizer non - significant on, number of leaves of Mungbean and weight 1000 grain seed for two crops.3 - Results also showed a significant Interaction between nitrogen fertilizer and intercropping pattern ,the highest leaf area; leaf area index; number of seed in pod and biological yield of Mungbean, obtained at treatment (F4*S2),. Intercropping of Sorghum and Mungbean (1 : 1) with nitrogen 200 kg N ha - 1 gave 6.56 t ha - 1 grain yield of Sorghum .The interaction between two planting system non - significant on almost characteristics that mean both two system gave nearly results by effected addition nitrogen fertilizer

تاثير احلال الشعير المحسن باستخدام التخمير بسائل الكرش واضافة الانزيمات محل الذرة الصفراء في بعض الصفات الانتاجية والفسلجية والكيكروبية لفروج اللحم == The effect of bringing improved barley by fermentation rumen fluid and adding enzymes replace maize in some productive traits , physiological and microbial for broiler chickens

اسم المؤلف: وليد هيلان سعدون راضي الموسوي
اسم المشرف: عبد الله عبد المنعم محمد
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الاغذية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: The current study included two experiments, The labrotary experiment was carried out to investigate the effect of fermented barley with rumen liquor (10 , 20 ml / kg barley) at different inclusion periods (7 ,14 and 21 days) . The results of chemical analysis to crud protein , fat and ash percentage for fermented barley showed increased, and fiber percentage decreased on 10 and 20 ml rumen liquor at 14 days fermented period . The second experiment was included the effect of addition fermented barley by 20 ml rumen liquor for 14 days . A total of 360 unsexed one day old chicks were randomly distributed to eight treatments in three replicated ( 15 chicks/ replicate) . During the experimental period 35 days two diets were fed starter and grower .The treatments as follow : 1 - First treatment of control included 50% maize .2 - Second treatment included the replacement of barley in the rate of 25%. 3 - Three Treatment included the replacement of barley in the rate of 50%.4 - Fourth treatment included the replacement of barley in the rate of 75%.5 - Fifth treatment included the replacement of barley in the rate of 100%.6 - Sixth treatment included the replacement of barley in the rate of 25%+1 g enzymes/ kg feed7 - Seventh treatment included the replacement of barley in the rate of 50% + 1 g enzymes/ kg feed .8 - Eighth treatment included the replacement of barley in the rate of 75%+ 1 g enzymes/ kg feed.The results of this studies indicated that : 1. A significant increase(P <0.05) of mean body weights and body weight gains in T2 as compared with the control treatment while T3 and T4 showed non significant differences as compared with control .2. A significant increase(P <0.05) of accumulative feed consumption and feed conversion efficiency of T5 and T8 but T2 and T3 were given a least significant differences compared with control.3. Non significant increase(P <0.05) of dressing percentage for T2 , T3 and T4 as compared with control treatment . b 4. Treatments T2,T3 , T4 and T5 showed a significant differences (P <0.05) in relative weight of gizzard and cecum compared with enzymes treatments.5. A significant differences of hemoglobin of all treatments as compared with control , while glucose levels were significantly(P <0.05) increased in control and treatments treated with rumen fuid compared with enzyme treatments . but T1 and T2 showed highly significant (P <0.05) in cholesterol levels as compared with others .6. There were significant differences (P <0.05) in logartmic numbers of total bacteria, lactobacillus and bacteria degrading cellulose in rumen fuid treatments as compared with others.7. T2 , T3 ,T4 showed significant differences (P <0.05) in intestinal length as compared with others, while T3,T4,T5,T6,T7 and T8 showed a significant (P <0.05) increase passage rate compared with T1 and T2 .8. T2 and T3 recorded less significantly differences (P <0.05) in viscosity intestinal contain as compared with other treatments . 9. Treatments treated by barley fermented with rumen fuid showed a highly significant (P <0.05) in tibia length , tibia ash percentage , tibia calcium and phosphorus contains as compared with control and treatment treated with enzymes .10. A significant differences (P <0.05) in villus length and the ratio between the length and depth in all treatments as compared with control .11. No significant differences in all treatments as compared with control in the carcass quality .12. The economical benefits of the study fed barley fermented rumen fuid T2,T3,T4 and control showed significant differences (P <0.05) in production index and production coefficient as compared with enzymes treatments.

فصل دهون صفار بيض الدجاج والبط والوز والنعام المحلي ودراسة محتواها الكيميائي وتاثير الخزن على صفاتها الفيزيائية والكيميائية == Separation of local Chicken, Duck, Gees and Ostrich Egg Yolk Fat and Study it’s Chemical Contents and effect of storage on physical , chemical properties

اسم المؤلف: وفاء علي رحيم الشويلي
اسم المشرف: ام البشر حميد جابر الموسوي
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الاغذية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: تضمنت هذه الدراسة فصل دهن صفار بيض الدجاج والبط والوز والنعام ودراسة ومحتواه من العناصر المعدنية والاحماض الدهنية المشبعة وغير المشبعة والكولسترول والبروتينات الدهنية (اللايبوبروتين) والدهون الفسفورية (الفوسفولبيدات) والكاروتينات والفيتامينات وصفاته الفيزيائية والكيميائية ومتابعة هذه الصفات بعد مدة خزن 30 و60 و90 يوما.وقد كانت النتائج مايلي.1 - اظهرت نتائج دراسة المحتوى الكيميائي لصفار البيض وجود فروق معنوية بين انواع المدروسة فتراوحت نسبة الرطوبة من 46.60% الى 49.34% في النعام والدجاج على التوالي، والدهن من 31.63% الى 34.65% في بيض الدجاج والوز على التوالي، والبروتين من 15.55% الى 16.75% في بيض الوز والنعام على التوالي، والرماد من 1.00% الى 1.33% في بيض الوز والنعام على التوالي، كان صفار بيض الوز الاعلى في نسبة الدهن.2 - اظهرت نتائج تحليل العناصر المعدنية في الصفار ودهن الصفار ان عنصر الحديد كان اعلى تركيز مقارنة بالعناصر الاخرى فتراوح تركيزه من 8.52 PPM الى 10.08 PPM في الصفار ومن 2.44 PPM الى 9.16 PPM في الدهن، اما العناصر الاخرى فتباينت تراكيزها حسب انواع البيض المدروسة اذ تراوح عنصر الرصاص من 2.48 PPM الى 4.58 PPM في الصفار ومن 2.05 PPM الى PPM 2.53 في الدهن وعنصر الزنك من 0.808 PPM الى 0.852 PPM في الصفار ومن 0.02 PPM الى 2.92 PPM في الدهن اما عنصر الكادميوم فتراوح من 0.117 PPM الى0.259 PPM في الصفار ومن 0.067 PPM الى 0.081 PPM في الدهن وعنصر النحاس من 0.01 PPM الى 0.215 PPM في الصفار ومن 0.05 PPM الى 0.74 PPM في الدهن.3 - قدرت الاحماض الدهنية الكلية في دهن صفار بيض الدجاج والبط والوز والنعام وشخصت كمية الاحماض الدهنية ونوعيتها بتقنية الكروموتوغرافيا الغاز المتصل بمطياف الكتلة Gas Chromatography / Mass Spectrometry (GC - MS) واظهرت النتائج ان نسبة الاحماض الدهنية المشبعة وغير المشبعة في دهن صفار بيض الدجاج كانت 45.14% و54.66% على التوالي، وفي دهن صفار بيض البط 45.89% و54.11% على التوالي، اما دهن صفار بيض الوز فكانت نسبة الاحماض الدهنية المشبعة فيه 33.02% وغير المشبعة 65.61% وبلغت اعلى نسبة للاحماض الدهنية غير المشبعة في دهن صفار بيض النعام 82.36% اما الاحماض الدهنية المشبعة 17.11%.4 - قدر محتوى الكولسترول باستعمال الطريقة الكيميائية اذ بلغت اعلى نسبة له في دهن صفار بيض الدجاج 13.56ملغم /غم ثم يليه دهن صفار بيض الوز بنسبة 11.02ملغم /غم، اما نسبته في دهن صفار بيض البط والنعام فقد كانت متقاربة وهي 10.70 و10.60ملغم /غم على التوالي.5 - قدرت تراكيز البروتين الدهني الواطئ الكثافةLow Density Lipoprotein (LDL) والبروتين الدهني العالي الكثافةHigh Density Lipoprotein (HDL) والبروتين الدهني واطئ الكثافة (vLDL)Density Lipoprotein Veryبجهاز Rflatron في دهن صفار بيض الدجاج والبط والوز والنعام وكانت تراكيز HDL في دهن صفار بيض الدجاج والبط والوز والنعام ( 50 و15و9 و93 ) mg/dl على التوالي، اما LDL فقد كانت ( 20 و21و 18 و33 ) mg/dl وvLDL بلغت ( 327 و253 و239 و250 ) mg/dl على التوالي.6 - قدرت نسبة الدهون الفسفورية في دهن صفار بيض الدجاج والبط والوز والنعام وبحسب انواعها Phosphatidyl choline (PC) وethanolamine (PE) Phosphatidyl وlinositol (PI) Phosphatidyl وكانت اعلى نسبة PC مقارنة بالفوسفولبيدات الاخرى لجميع انواع الدهن المدروسة حيث تراوحت قيم PC من 54.3 الى 83.7 في دهن صفار بيض الوز والدجاج على التوالي وPE من 4.7 الى 29.1 دهن صفار بيض الدجاج والوز على التوالي وPI من 2.2 الى 11.3 في دهن صفار بيض الدجاج والوز على التوالي.7 - بينت النتائج ان جميع انواع الدهون المدروسة احتوت على الفيتامينات A وD وE وK ولكن بنسب متفاوتة اذ تراوحت النسبة المئوية لها من 10.2 - 50.8 % لفيتامين A ومن 0.6 - 2.2 % لفيتامين D ومن 11.4 - 32.5 % لفيتامين E ومن 0.4 - 4.5 % لفيتامين K.8 - كان اعلى تركيز للكاروتينات في دهن صفار بيض الوز 192.29 ملغم/غم يليه دهن صفار النعام185.26 ملغم/غم ثم دهن صفار بيض الدجاج 136.83 ملغم/غم ودهن صفار بيض البط 109.56ملغم/غم.9 - الصفات الفيزيائية لدهن صفار بيض الدجاج والبط والوز والنعام : - - كانت قيم نقطة الانصهار في دهن صفار بيض الدجاج 40 م° والبط 41 م° والوز 39م° والنعام 30 م° وقد لوحظ انخفاض تدريجي خلال مدة الخزن. - اظهرت نتائج التحليل الاحصائي ان قيمة اللزوجة تاثرت معنويا (P<0.05) بين جميع انواع الطيور حيث تراوحت من 10.22الى 16.36 سنتي بويز في دهن صفار بيض الدجاج ومن10.67 الى 17.13سنتي بويز في دهن صفار بيض البط اما في دهن صفار بيض الوز والنعام انخفضت اللزوجة من 15.13 الى 9.45 و13.29 الى 8.2 سنتي بويز على التوالي، وقد تاثرت معنويا بتقدم فترات الخزن. - بينت النتائج ان قيمة معامل الانكسار لدهن صفار بيض الدجاج والبط والوز والنعام كانت 1.4663 و1.4661 و1.4665 و1.4671 على التوالي، وانخفضت خلال مدة الخزن اذ اتضح من نتائج التحليل الاحصائي وجود فروقات معنوية بينها. - اما قيم الوزن النوعي فقد تاثرت معنويا (P<0.05) بمصدر الدهن وكانت اعلى قيمة للوزن النوعي في دهن صفار بيض النعام 0.9663 وادنى قيمة في دهن صفار بيض الدجاج 0.9622 اما في دهن صفار بيض البط والوز فقد كانت قيمة 0.9632 و0.9650 على التوالي، وقد تاثرت معنويا بتقدم فترات الخزن.10 - اشارت الدراسة الى الصفات الكيميائية لدهن صفار بيض الدجاج والبط والوز والنعام اذ : - اظهرت نتائج التحليل الاحصائي وجود فروق معنوية (P<0.05) لتاثير مدة الخزن على قيم الرقم اليودي وتراوحت القيم لدهن الصفار بين اقل قيمة في دهن صفار بيض الدجاج 60 واعلى قيمة في دهن صفار بيض النعام 85، اما دهن صفار بيض البط والوز فكانت 67.33 و72.3 على التوالي، وقد انخفضت قيم الرقم اليودي باستمرار مدة الخزن. - اما قيم البيروكسيد فقد بلغت اقل قيمة لها في دهن صفار بيض الوز 0.18 مليمكافئ /كغم واعلى قيمة للبيروكسيد في دهن صفار بيض النعام 0.34 مليمكافئ /كغم ثم دهن صفار بيض البط 0.31 مليمكافئ /كغم واخيرا دهن صفار بيض الدجاج 0.22 مليمكافئ /كغم وقد ارتفعت قيمة البيروكسيد باستمرار فترة الخزن. - بلغت قيم التصبن لدهن صفار بيض الدجاج والبط والوز والنعام ( 175.2 و179.45 و190.2 و170.2 ) مليمكافئ /كغم على التوالي، وقد ارتفعت قيم التصبن باستمرار مدة الخزن. - كما اظهرت نتائج التحليل الاحصائي وجود تاثر معنوي في قيم الحموضة لدهن صفار بيض الدجاج والبط والوز والنعام اذ كانت 0.28 و0.31 و0.56 و0.40 ملغم KOH /غم على التوالي، وقد لوحظ ارتفاع قيم الحموضة تدريجيا خلال مدة الخزن | The current Study including of separating chicken, duck, goose and ostrich egg yolk fat and studying its Content of the metallic elements Free fatty acid cholesterol , Lipoproteins , Phospholipids , Carotenes , Vitamins , and its Physical and Chemical properties and flowed after period of storage for 30, 60, 90, days. The results were as follow : 1 - The results of the study of the chemical contents showed significant differences among the sorts of the studied egg and the percentage of the moisture Varied from 46.60% to 49.34% the oil from 31.63% to 34.65% , the protein from 15.55% to 16.75% the ash from 1.00% to 1.33% and the yolk egg of the ducks got the highest percentage of oil . 2 - The results of the metallic elements analysis in the yolk and the oil of the yolk showed that the iron element was the highest in concentration in comparison with other elements . lt varies from 8.52 ppm to 10.08 in the yolk and from 2.44ppm to 9.16ppm in oil . As for the other elements its concentrations varied according to the types of the egg which was used in the study . According to the pb 2.48ppm to 4.58ppm in yolk and from 2.05 to 2.53ppm in the oil , and Zinc element from 0.808 to 0.852ppm in the yolk and form 0.02 ppm to 2.92ppm in the oil . As for the Cadmium element from 0.117 to 0.259ppm in yolk , and 0.067 to 0.081ppm in oil and the CU element varies from 0.01 to 0.215 ppm in yolk and from o.o5ppm to 0.74 ppm in the oil . 3 - The total free fatty acid to the oil of the yolk in the egg of chicken and ducks and ostrich was amounted and the quantity , and quality of the fatty acid was identified by the technique of gas chromatography by mass Spectrometry GC - MS .The results showed that the percent of saturated fatty acid and unsaturated fatty acid for the oil of the yolk in the egg of chicken was from 45.14% and 54.66% respectively and for the oil of the egg of the ducks was from 45.89 to 54.77%, while oil in the yolk of the Gooses egg was 33.02% saturated and 65.661% unsaturated . The highest percentage of the unsaturated fatty acid in the oilof ostriches egg which was 82.36% , while the saturated was 17.11%. 4 - The cholesterol was amounted by using the chemical method where the highest percentage in the yolk oil of the chicken eggs which was reached 13.56 mg/100g . and the duck. Comes then which reached to 11.02 ,while its percentage in the yolk oil of the ducks and ostrich's was approximately 10.70 and 10.60 respectively . 5 - The Concentrations of the Low Density lipoprotein ( LDL ) and the high density lipoprotein by the Rflatron in the yolk oil of the egg of chicken, ducks , Geese and Ostrich and the concentrations were 93,5,15and 50 respectively .while LDL was 33,18,21,20 and vLDL were reached 350, 239, 253 and 327 respectively. 6 - The amount of lipid phosphate in the yolk of the chicken, ducks, Geese, and ostriches egg according to its types (PC) phosphatidyl and ethanolamine (PE) and phosphatidyl inositol (Pl) for all types of the studied yolk were varied from 54.3 to 83.7 for (PE) from 29.1 to 4.1 and (Pl) from 2.2 to 11 .7 - The percentage of vitamin were showed that all lipids studied contained deferent vitamins A, D, E, and K 10.2 - 50.8% for Vit, A , 0.6 - 2.2% for Vit. D, 11.4 - 32.5% for vit. E and 0.4 - 4.5% for vit. K . 8 - The Creations was amounted and the highest Concentration was noticed in the oil of yolk of the Geese mg/g and then the oil of the chicken egg, and the oil of the ducks egg. 9 - The physical properties of the oil in chicken ,ducks, Geese's , ostrich egg were as followed : - The amount of polting point in the oil of the yolk in the chickens egg 40C0 and 41C0 and Geese's 41C and ostriches 30m0 and it reached to alow point through the time of storage . - The result of the statistical analysis showed that the amomt 0f viscosity was influenced (P<0.05) among all types of birds where varied from 16.36 to 10.22 in the oil of the yolk of the chicken egg and from 10.67 to 17.13 in ducks while in Geese and ostrich was lowered from 15.13 to 9.45 and 13.29 to 8.2 respectively . - The results showed that refractive index for the oil in chicken was 1.4663 in ducks was 1.4661 in Geese was 1.4665 and in ostrich was 1.4671 and it was decreased during the period of storage and the statisticed analysis showed that there are significance differences among them. - As for the amomt of the weight it was inflamed by the source of the oil and the highest amount was for the oil in the yolk of ostrich egg 0.9663 and the lowest amomt in chicken 0.9622 while the ducks was 0.9632 , 0.9650 respectively . 10 - The chemical Properties for the yolk lipid of chicken , geese, duckes and ostrich were as follows : - The statistical analysis result showed that there were differences (P<0.05) in period of storage for the lodic number which was from the lowest amount in the chicken egg (60) and highest in lipid of the ostrich egg 85 , while the ducks and geese 67.33 and 72.3 respectively , and the lodin number amomts were decreased by the continuity of the peviod of storage. - The peroxide value reached smallest amount value in geese yolk egg 0.18 mq/kg and highest amount value in ostrich yolk egg oil 0.34 mq/kg then ducks yolk egg oil 0.31 mq/kg finally chicken yolk egg oil 0.22mq/kg and the peroxide value increased by the continuity of the storage period . - The saponification value of chicken egg yolk oil 175.2 mq/kg and ducks yolk egg oil 179.45 mq/kg geese yolk egg oil 190.2 mq/kg and ostrich yolk egg oil 170.2 mq/kg a high point by the continuity of the story period. - The statistical analysis result showed that there is an effect on the acid yolk oil it was 0.40,0.56,0.31, 0.28/KOH respectively and the amount of acid value were increased through the period of storing

دراسة بعض التغيرات المرافقة لتلقيح وعقد ثمار النخيل Phoenix dactylifera L صنفي الحلاوي والساير == study of some accompanying changes to pollination and fruit set of date palm Phoenixe dactylifera L.CV. Hillawi and Sayer

اسم المؤلف: وسن فوزي فاضل عباس الابریسم
اسم المشرف: مؤید فاضل عباس | ابتھاج حنظل التمیمي
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات
الدرجة: دكتوراه
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: The present study was carried out during the growing season of 2014 and 2015 in a private orchard in Shatt Al - Arab with the objective of knowing the effect of pollination 1, 2, 4 and 8 day from opening of female spathes, source of pollen (Ghannami Akhder and Smasmii) and by passing pollination process by spraying unpollinated flowers with the growth regulators and ethephon on certain aspects of the physiology and anatomy of date palm fruits cvs. Hillawi and Sayer. The results may be summarized as follows : 1 - The date pollination had no effect on fruit growth curve, but had a significant effect on length of the khalal stage which was 22, 18, 16 and 15 days for the cv. Hillawi and 24, 20, 18 and 17 days for the cv. Sayer, for the pollination dates 1, 2, 4, and 8 from opening of female spathes. The fruits of Hillawi and Sayer cultivars entered the tamr stage after 19 and 20 weeks from pollination respectively.2 - Fruits produced from flowers pollinated 8 days from opening during the khalal stage was superior in all physical characteristics of the fruit, with the exception of seed weight, which had its highest weight during the first date of pollination, however therewere no significant differences in fruit for both growing seasons, fruits of the cv.Hillawi had the highest values of physical characteristics in cooperation with those of Sayer cv.3 - As for Chemical characteristics of the fruits, the fourth pollination date (8 days from flower opening) gave a significantly highest value of total soluble solids, total sugars and dry matter. The highest values for reducing sugars was recorded during the second date of pollination( 2 days after female spathes opening), fruits of athe cv. Hillawi had the highest values for all those chemical constituents with its highest value with fruit of Sayer cv. 4 - These was significant difference of the unpollinated flowers in free amino acid and soluble proteins content, The second date of pollination gave the highest concentration of free amino acids 3.269mg.g - 1, whereas the fourth pollination date gave the highest1.856mg.gP - 1 P . As for the date of sampling , the fruits record during the third date ( 5 days after pollination) had the highest concentration of both free amino acids and soluble proteins, fruits of the cv. Hillawi had a significantly high concentration of both chemical constituents in comparison with fruits of the Sayer cv.5 - The results showed, that there were significant difference in the concentration of both auxin and cytokinins of the flowers ،422.5 271.5, where the second date of pollination gave the highest concentration of both hormones in the flowers, the date of sampling after pollination, had no effect on the concentration of auxins. however, the third sampling date( 5 days from pollination) had the highest of cytokinins in young fruits cv. Hillawi had the highest values with fruit of Sayer cv. .6 - The fourth date of pollination had the highest percentage ripening whereas the second date of pollination gave the highest fruit set percentage bunch weight during the rutab stage. Fruits of the cv. Hillawi was superior with respect to percentage fruit set, percentage fruit ripening, bunch weight as compared with fruits of the cv. Sayer. As for the effect of pollen source7 - The pollen source had no effect on fruit growth curve, but had a significant effect on the length of the khalal stage, the length of the klalal stage for fruit produced by the pollen Ghannami Akhdar wasb18 and 21 days for fruits of the cvs.Hillawi and Sayer respectively, whereas the length of the khalal stage for fruits produced the Smasmii pollen was 21 and 25 days for both cultivars respectively.8 - Fruit pollinated by Ghannami Akhdar had the highest values for the physical characteristics, as compared with fruits produced by the pollen Smasmii the pollen source Ghannami Akhdar recorded.9 - the highest values for total soluble solids and dry matter, whereas the pollen source Smasmii gave the highest value for the water content and total acidity. Fruit of the cv. Hillawi had the highest value for those chemical constituents as compared with fruits of the cv. Sayer.10 - As for sugars, the increase in reducing and total sugars was slow during early stage of fruit growth, thereafter, there was a rapid increase in sugars which reached its highest values during the 18 the week from pollination. For sucrose, its content in the fruit was at its highest during the 16 th week from pollination. Fruit produced by the pollen source Ghannami Akhdar had a significantly higher content of reducing and total sugars as well as sucrose. Fruits of the cv. Hillawi had a significantly higher sugars as compared with fruits of the Sayer cultivar.11 - As for changes in the activity of the enzymes invertase and cellulose the activity was low during early stage of fruit growth, and the highest level of activity was recorded during the 16 th week from pollination for both enzymes, for fruits of both cultivars. However, the activity of both invertase and cellulose was high for fruits of the Hillawi cv.2093, 787.7 As compared with fruits Sayer.12 - As for auxins, the concentration was in unpollinated female flowers. Fruits produced by the pollen Ghannami Akhdar had the highest concentration of auxins397.3 as compared with fruitscproduced by the pollen source Smasmii, the fifth sampling date( 7 days from pollination) gave the highest auxin concentration of young fruits. The unpollinated flowers of the cv. Hillawi had a significantly higher concentration of auxins as compared with those of the Sayer cv.13 - The study of embryogenesis of female flowers have shown that the process of fertilization took place after 2 days for flowers of Hillawi and Sayer pollinated by the pollen source Ghannami Akhdar, whereas fertilization took place after three days for flowers pollinated with pollen source Smasmii. However, the cv. Hillawi was superior in those characters as compared with the sayer cv.14 - The pollen source also, had a significant effect on percentage fruit set and fruit ripening, bunch weight as compared with fruits produced by the pollen Smasmii. However, fruits of the cv. Hillawi was a significantly superior, in those characteristics.15 - As for the by passing of the process of pollination by treating unpollinated flower with gibberellic acid and ethephon, such treatments had no effect on fruit growth curve, for both cultivars.16 - As for anatomical characteristic of parthenocarpic fruits not treated with gibberellic acid and ethephon(control), it gave the highest number of layers of exocarp, hypodermis and stone cells. The seeded fruits had the highest thickness of the inner mesocarp. Fruits of the cv. Sayer was superior with respect to thickness of the exocarp cells, hypodermis and stone cells, outer and inner mesocarp and tannin cells 259.6, 117.9, 117.8, 810.0, 3734, 773 μm Also, there were a change in the number as the Sayer cv 630.0mmPP. Had the highest number of cells as compared with fruits of the cv.Hillawi. The Hillawi showed the highest width of cells 72.5 μm, as compared with the cv. Sayer, but there were no difference in cell length. The control treatment gave the highest number of cells in pith tissues of parthenocarpic fruit, whereas the seeded fruit gave the highest length and width of cells.17 - treatment with gibberellic acid and ethephon had a significant effect on chemical characteristics of the parthenocarpic fruits treatment with 200mg.l - 1 +1000mg.l - 1 ethephon, caused a significant increase in total sugars and reducing, total soluble solids, and ripening percentage 56.09, 47.97, 59.09, 23.09% for parthenocarpic fruits of both cultivars Hillawi and Sayer. e

تاثير التلقيح ببعض الفطريات المعزولة من الترب الزراعية في المعالجة الحيوية للترب الملوثة بالمخلفات النفطية في محافظة البصرة == Effect of inoculation by some fungi isolated from agricultural soils in the bioremediation of contaminated soils with oil waste in Basrah

اسم المؤلف: هدى حاكم سعدون الاسدي
اسم المشرف: ميعاد مهدي الجابري
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: التربة والمياه
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: For the purpose of identifying the efficiency of inoculation different genus of fungi isolated from agricultural areas in the bioremediation of soil contaminated with petroleum hydrocarbon nearby regions from some the oil fields in the province of Basrah, southern Iraq, and the impact on plant growth as has been selected sites west of Qurna fields and North Rumaila fields, mixed with non - contaminated soil from the same areas at rates of 100% and 75% and 50% to reduce the pollution of oil hydrocarbons ratio.Isolation and purification of two species from fungus Aspergillus (A. niger and A. versicolor), Trichoderma viride and Penicillium citrinum from Five of agricultural areas (Shatt Al - Arab, Garma Ali, Al - Zubair, Al - deer and Abu Al - khaseeb) and studied the possibility of its adaptation and its growth in nutritional media contaminated with the quality of the two regions of oil each separately and inoculated the soil treatments that represent percentages above and inoculated at a temperature of 25 ᵒC to study the total numbers of bacteria and fungi and CO2 amount from Activity microbial in soil and estimated the amount of hydrocarbons broken by the inoculation process fungal soil every 10 days for 60 days of incubation.Agricultural experiment carried out by tested the most efficient of the two fungi in degraded hydrocarbons for each soil and for each contamination level in addition the treatment of a mixture of the most efficient of the two fungi and control treatment (without pollination), left after the treatments for two months with maintaining the humidity at around 75% of field capacity in a way to compensate the weight loss and planted them maize seeds Zea mays L. class Bhooth 106 and after 45 days of germination was estimated proportion of hydrocarbons broken and some parameter of plant growth as a rate of plant length, dry weight of the shoot and the quantity N, P and K absorbed in plant. Were obtained the following results : 1. increase the number of the total fungi and bacteria with time in soils inoculated with isolated fungi to Limit 60 days compared to the control treatment in which the increase lasted only 40 days in the pollution levels of 75% and 100%, while the increase continued to 60 days at the level of 50% of all pollination treatments, including the control treatment.2. increase the amount of CO2 liberated from Bioactivity with time in soil inoculated fungal treatment compared with control treatment and fungal isolates varied in their efficiency to stimulate biological activity, and mitigate pollution of soils to the extent of 50% contributed to the increase in the vital activity of soils represented an increase of the amount of the liberated CO2 .3. inoculation contaminated soils fungal isolates led to increase petroleum hydrocarbon ratio analysis with time and varied fungal isolates in their ability to biodegraded hydrocarbon wholly followed the following sequence : Aspergillus niger > Penicillium citrinum > Trichoderma - viride > Aspergillus versicolor in the soil of North Rumaila and sequence : Penicillium citrinum < Trichoderma viride < Aspergillus niger <Aspergillus versicolor in soils west of Qurna fields and gave the pollution level 50% higher analysis of petroleum hydrocarbon ratio compared to levels of 75% and 100%.4. Inoculate all levels of contamination by fungal isolates most efficient led to increasing lengths and dry weight of the plant maize and increase the quantity absorbed N, P and K by the plant and were observed increase in the proportion of hydrocarbons degraded at the end of the agricultural experiment.5. Soil North Rumaila showed a response to the inoculation of fungi in all levels of contamination of soil over Western Qurna fields in terms of the total numbers of fungi and bacteria and amount of the liberated CO2 and hydrocarbon ratio degradation as well as an increase in parameters of all the maize plant growth.6. The fungus Penicillium citrinum and Trichoderma viride Showed more efficient in increasing the activity and bioremediation in soil Western Qurna fields, while the fungus Aspergillus niger is the most efficient in the soil of the North Rumaila

تاثير التسميد الفوسفاتي والعضوي في صور فسفور التربة وعلاقتها بجاهزية لمحصول الذرة الصفراء Zea mays L في بعض الترب الكلسية == Effect of Phosphate and Organic Fertilization on Soil Phosphorus Forms and its Relationships With its Availability to Corn Crop (Zea mays L.) in Some Calcareous Soils

اسم المؤلف: هبة كلف رزاق القريشي
اسم المشرف: هيفاء جاسم حسين التميمي
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: التربة والمياه
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: For the purpose of phosphorus forms Knowledge in Basra Province Soils, and effect of phosphate Fertilization with Concentrated Super phosphate and Organic Fertilization with cow manure on Phosphorus Forms ,the study was carried out with in three sectors : - First : Field study : Soil samples were taken from tweleven location in Basra province, 1/Gurna,2/Medayna,3/Diar,4/Hartha,5/Garmat Ali,6/Garmat Ali - Basra University,7/Brahdia,8/Tanoma,9/Abul - Khaseeb - Hamdan,10/ Abul - Khaseeb - Center,11 /Seeba ,and 12/ Fao. Soil properties wer determined and different forms of soil phosphorus were extracted Which were soluble phosphorus ,phosphorus associated with Calcium (Ca - P),Phosphorus associated with aluminium (Al - P) ,Phosphorus associated with iron (Fe - P), available phosphate (Av - P), Mineral phosphate(M - P) ,organic phosphate (O - P), residual phosphate (R - P), and total phosphate (T - P) .Second : Effect of phosphate and organic Fertilization on phosphorus forms : - Laboratory experiment was conducted by using two levels of phosphate fertilizer (0,0.65gmPkg - 1 soil) as concentrated super phosphate and two levels of cow manure (0,2.5%) for all studied soils. Soils wer inculcated at 30ºc for one month . Soil phosphorus forms were extracted and determined .Third : Effect of phosphorus forms on Maize growth parameters : - Biological experiment was conducted by using maize crop (Zea mays L.) according to factorial experiment with complete design including the following factors [soil*(phosphate fertilizer, cowmanure, * phosphate fertilizer cowmanure with control) *replicates](10*2*2*3) summing to 120 experimental units, after exclusion Seeba and Fao soils because of their high Salinity .Two levels of phosphate fertilizer were used (0,100kg P ha - 1) as concentrated super phosphate , and two levels of organic fertilizer (0,30ton ha - 1)as cow manure mixing with Soils. Nitrogen was added at rate of 320 kg N ha - 1 as urea with two doses For all soils , first dose at planting (15/3/2015) mixing with soil and the second dose after one month of planting with irrigation water .Potassium was added with rate of 120kg K ha - 1 as potassium sulfate mixing with soils at planting .Plants were harvested after 60 days and shoots were dried at 65ºc inIIoven and dry matter was recorded. Dry Shoots were digested and phosphorus concentration was determined , and phosphorus uptake was Calculated.The results of the study showed the following : - 1 - Soluble phosphorus concentration values ranged between (0.27 to 1.85) mg L - 1 with a mean value of 0.99 mg L - 1, phosphorus associated with Calcium between (104.40 to 226.10) mg kg - 1 with a mean value of 169.16 mg kg - 1 , phosphorus associated with aluminium between (0.42 to 0.99) mg kg - 1 with a mean value of 0.70 mg kg - 1 , phosphorus associated with iron between (0.09 to 0.76) mg kg - 1 with a mean value of 0.38 mg kg - 1 , Available phosphorus between (10.10 to 25.65) mg kg - 1 with a mean value of 18.11 mg kg - 1 , mineral phosphorus between (139.57 to 250.40 ) mg kg - 1 with a mean value of 198.27 mg kg - 1 ,organic phosphorus between (50.12 to 89.70)mg kg - 1 with a mean value of 77.62 mg kg - 1 , residual phosphorus between (6.00 to 12.00)mg kg - 1 with a mean value of 8.91 mg kg - 1 and total phosphorus between (229.27 to 306.88) mg kg - 1 with a mean value of 275.88 mg kg - 1 .2 - Result of simple correlation coefficient (r) Showed that soil salinity had significant effect in phosphorus associated with Calcium (r=0.589*), and negative correlation with available phosphorus (r= - 0.641*). Calcium Carbonate content had a high significant effect on phosphorus associated with Calcium (r=0.992**), mineral phosphorus (r=0.899**), and total phosphorus (r=0.880**),and high negative correlation with available phosphorus (r= - 0.965++) and organic phosphorus (r= - 0.774++) . Organic matter had a significant effect on available phosphorus (r= 0.837++) , organic phosphorus (r=0.924++) , and total phosphorus (r=0.773++) , and negative significant effect with phosphorus associated with calcium (r= - 0.887++) , and mineral phosphorus (r= - 0.895++) . Soil pH ,CEC , Sand , Silt , and clay showed no significant effects on Soil phosphorus forms.3 - Laboratory experiment results showed that soils and fertilizing treatments (phosphoric , organic , and their interactions) had significant effect on phosphorus forms in studied soil . Effect of fertilizing treatments was followed the following : - Phosphate and organic fertilization > organic fertilization > phosphate fertilization .III4 - Soil and fertilizing treatments (phosphoric, organic, and their interactions) had significant effect on dry matter of shoot of corn crop, phosphorus concentration, and phosphorus uptake. Fertilizing treatments were taken the same manor in increasing of dry matter , phosphorus con centration, and phosphorus uptake as following : - Phosphate and organic fertilization > organic fertilization > phosphate fertilizationphosphorus uptake was taken the following arrangement in the studied soils : - Diar > Medayna > Brahdia > Tanoma > Hartha > Gurna > Garmat Ali - Basra University > Abul - Khaseeb - Hamdan > Abul - Khaseeb - center> Garmat Ali.5 - Result of statistical analysis of simple correlation coefficient (r)showed that phosphorus forms had no significant effect on dry matter of corn shoot and phosphorus concentration ,While phosphorus uptake gave high significant correlation with available phosphorus (r=0.959**) and organic phosphorus (r=0.954**).

دراسة تاثير المخلفات النباتية والحيوانية والفطر الاحيائي Trichoderma viride في مكافحة مرض تعفن جذور الباميا المتسبب عن الفطر Macrophomina phaseolina == A study of effect of plant and animal residues and the bioagent Trichoderma viride in controlling okra root rot disease caused by Macrophomina phaseolina

اسم المؤلف: نور مهدي صالح المالكي
اسم المشرف: ضياء سالم علي الوائلي
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات - الوقاية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: This study aimed to use plant and animal residues and bioagent Trichoderma viride against pathogenic fungus Macrophomina phaseolina which caused okra root rot disease in pots and field and to detect the active compounds in okra leaves by GCMS technique.Three pathogenic fungi were isolated from infected plants, they were M.phaseolina , Rhizoctonia solani and Fusarium solani .The fungus M.phaseolina gave the highest percentage of occurance and freguencywhich were 55 and 66.67% .The pathogenicity test showed that M.phaseolina led to decrease germination pereen and increase damping - off up to 20 and 26.67% respectively, compared to control treatment which was 80 and 0% respectively.The results explained that the animal manure (F) , rice (R) and wheat (w) led to increase the germination percent up to 66.67% , 60 and 53.3% respectively compared to control treatment which was 40% , the fresh weight also increased in the same treatments up to 1.36 , 1.25 and 1.28 gm respectively compared to control which was 0.64 gm .It was founed the less infection intensity with M.phaseolina in pots was noticed in the treatment RTv (bioagent +rice) and FTv (bioagent+animal manure), it was 0% compared to control treatment which was 90%, which the highest shoot weight and plant height were noticed in the treatment FTv which were 6.22 gm and 32.03 cmrespectively compared to control which were 1.33 gm and 22.55 cm. The field experiment results revealed that the less infection intensity was observed in the treatment FTv which was 0% compared to control which was 62.22% .The treatment RTv gave a high shoot weight which was 156.11 gm compared to control which was 46.39 gm, while the high plant height was obsrved in the treatments RTv and FTv which were 73.9 and 71.98 gm respectively compared to control which was 40.33 gm. It was also founed that the high plant production was noticed in the treatment RTv and FTv which were 64.53 and 63.10 gm respectively compared to contorl which was 1.44 gm.From the other hand ,the total chlorophyl was noticed in the treatment RTv ,R,FTv,wTv and F which were 1728,224 ,1629.96,1454.442,1377.884 and 1281.168 mgm/100gm fresh weight respectively compared to 359.9 mgm/100gm fresh weight. The results of phenotic compouneds detection in the plant leaves by using GCMS technique revealed a presence of some compouneds such as Pentanol, 1,2,4 Triazole and Cyclohexanol with the treatments RTv,FTv and wTv ,these compouneds were not been recorded in the other treatments.

تاثير نظم الحراثة في نمو وحاصل الذرة الصفراء Zea mays L المزروعة بطريقتي المروز والسطور . == Effect of Tillage system on the growth and production of corn (Zea mays L. ) that cultivation by ridge and seed drilling

اسم المؤلف: نور صالح عبد الجليل حسون الحميداوي
اسم المشرف: شاكر حنتوش عداي | وليد عبد الرضا جبيل
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات - المحاصيل الحقلية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: field experiments was conducted in Almdiana district in autumn season 2014 - 2015 in ALmalha Irrigation project , to study effect the tillage system in the growth and yield of ( Zea mays L. ) that cultivated by ridge and seed drilling .The tillage system represent the main plots while the planting methods represent the sub - plots .The tillage system includes four plows namely, subsoiler , combined subsoiler , moldboard plow , harrowing chisel and zero tillage. The methods of planting include idge and seed drilling , The results were analyzed using complete randomize design within split - plots.The results showed that the tillage and planting methods them significantly effected on soil physical properties ( soil bulk density , penetration resistance , Ec and pH ) but the interaction was not significant .The highest soil bulk density was recorded for zero tillage and for the three periods of sample collection . the values of the soil bulk densities are 1.399 Mg.m - 3 while the lowest values were record for the combined subsoiler plow , the values are 1.254 Mg.m - 3 . For the other tillage being medium the values for the subsoiler plow are 1.346 Mg.m - 3 , they are harrowing chisel 1.336 Mg.m - 3, and moldboard plow are 1.316 Mg.m - 3 .For soil penetration resistance, the results showed that the combined subsoiler surpassed the other tillage in reducing soil penetration resistance , the values are 360.370 KN/m2 for the three periods respectively . while zero tillage treatment gave the highest values which they are 502.407 KN/m2 for the three periods respectively .The combined subsoiler plow also surpassed the other plow types in reducing Ec and pH . the lowest values were recorded for combined subsoiler , while the heights values were recorded for zero tillage.The results also showed that the tillage and planting methods significantly Effected the plant growth and production parameters , while the interaction was not significant in its effect on the studied parameters. The combined subsoiler surpassed the other plowing methods in all plant parameters studied which they are plant height , leaf area , ear length , number of ears per plant , seed production , biological production , number of seeds per row

دور المستخلصات المائية لبعض النباتات في تحولات النتروجين ونمو نبات الذرة الصفراء L. Zea mays في تربة معاملة بالمخلفات العضوية == Role of Some Plant Aqueous Extract on Nitrogen Transformation and Growth of Corn (Zea mays L .) in Soil Treated With Organic Residues

اسم المؤلف: مؤيد ابراهيم علي
اسم المشرف: عبد المهدي صالح حسين الانصاري
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: التربة والمياه
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: Series of incubation and pots experiments were conducted in laboratories and green house of the college of agriculture university of Basrah , to study the role of plants aqueous extracts of Caper seeds, pomegranate peels , date palm fiber and blady grass rhizomes and chemical nitrification inhibitor dicyandiamide (DCD) on nitrogen mineralization , nitrification inhibition, ammonia volatilization addition to growth and N,P,K conc. of corn plant grown in soil sandy loam treated with organic residues of poultry manure, cow manure, alfalfa residue and corn cubs.aqueous extracts were prepared at ratio of 1 : 10 ( plant material : water)and added at conc. of 0.25 ml gm - 1 soil to soil treated with 5% organic residue. Above experiments were repeated by addition of 500 mg N kg - 1soil as (NH4)2SO4 . Soils were incubated at 35 °C for 15,30,45,60 and 75 days . After each incubation period set of samples was withdraw and NH4+, NO3¯ were measured then nitrification inhibition was calculated . Ammonia volatilization was measured at 2,7,14,21,28,35,42,49 and 56 days of incubation. Dry weight, N, P and K conc. in plant was measured after 60 days of corn growth.Results of the study showed : 1 - Application of water extracts of caper seeds, date palm fiber and DCD significantly increased NH4+ - N release from organic residues . Highest increased obtained with caper extract .2 - Higher N mineralization (NH4+, NO3¯ ) was associated with poultry manure as compared with other organic sources.3 - Application of N fertilizer significantly increased of organic N release (NH4+, NO3¯ ) and decreased nitrification inhibition for all treatments.4 - Increasing incubation time significantly increased NO3¯ amount release, but decreased NH4+ amount release and nitrification inhibition .

تاثير الرش ببعض مضادات الاجهاد البيئي في بعض الصفات الفسيولوجية والتشريحية والانتاجية لنخيل التمر Phoenix dactylifera L. صنف الحلاوي == Effect of Spraying Some Environmental Stress Compounds on Some Physiological and Anatomical and Productivity Characters of Phoenix dactylifera L. CV. Hillawi

اسم المؤلف: منتهى عبد الزهرة عاتي سدخان
اسم المشرف: عل حسين محمد الطه
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات
الدرجة: دكتوراه
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: This study was conducted in a private orchard at Abu El - Khasseb District, Basrah Governorate during the growing seasons of 2014 and 2015 to investigate the effect of foliar spray of some environmental stress compounds of Fegeamino and Drin at concentrations of (2 and 4 ) ml.L - 1 and Ascorbic Acid at concentrations (500 and 1000)mg.L - 1 on some biochemical , anatomical characters and yield components of date palm cv. Hillawi during the ripening stage of Khalal , Rutab and Tamir. Results showed that Ascorbic Acid treatment at 500 mg.L - 1 recorded significant increases in fruit and flesh and seed fresh weight of the first season, fruit length and diameter of both seasons , moisture content of the first season , dry matter percentage of the second season , potassium to sodium ratio and thickness of inner mesocarp ,whereas Ascorbic Acid treatment at 1000 mg.L - 1 had significant increases in fruit total acidity of the second season , total chlorophyll and carotene pigments concentration of leaf ,proline concentration of leaf , peroxidase activity of leaf , exocarp and outer mesocarp thickness of fruit , bunch weight and total yield of tree at Tamir stage . Results showed also that Drin treatment at 2 ml.L - 1 recorded significant increases in vitamin C concentration of leaf, phosphorus and potassium concentration of leaf , peroxidase activity of fruit , tannin layer thickness, and fruit ripening percentage at Tamir stage , whereas Drin treatment at 4 ml.L - 1 had significant increases in fruit dry matter percentage of the first season , total soluble solids of the second season, free amino acids at Rutab stage , soluble protein of fruit at Khalal stage , total carbohydrates of leaf , nitrogen concentration , ,total chlorophyll concentration of fruit, catalase activity of leaf and fruit, and number of cells in mm2 of inner mesocarp. Fegeameno treatment at 2 ml.l - 1 gave significant increasesin fruit and flesh fresh weight of the second season , fresh weight ,gibberllins concentration, carotene pigment concentration of fruit , cell length and width ,whereas Fegeamino treatment at 4 ml.L - 1 had significant increases in seed weight of the second season , auxins , abscic acid concentration and vitamin C of fruit . Control treatment had significant increases in fruit moisture content of the second season , total soluble solids and total acidity of the first season, soluble protein of leaf and potassium to sodium ratio of leaf . Once and twice and trice sprays of trees with environmental stress compounds gave significant increases in most of the studied characters .Results of the most influencail bio - combination treatments were Fegeamino at 2ml.L - 1 with once spray which gave significant increases in fruit and flesh and seed fresh weight of the second season, fruit length of the first season and cell length ,whereas Fegeamino treatment at 2ml.L - 1 and twice spray gave significant increases in fruit ripening percentage , fruit soluble protine ,leaf potassium to sodium ratio, vitamin C of fruit and cell width , and Fegeamino treatment at 2ml.L - 1 and trice spray had significant increases in fruit dry matter percentage of the first season, carotene pigment concentration, gibbirellins concentration , exocarp thickness and number of cell in mm2 of inner mesocarp.Drin treatment at 4 ml.L - 1 and trice spray increased significantly fruit total acidity, free amino acids , fruit total chlorophyll and carotene pigment concentration and, catalase activity . Ascorbic Acid treatment at 500 mg.L - 1 with twice spray increased significantly fruit and flesh fresh weight of the first season, fruit length and diameter of the second season , and leaf soluble protein , whereas Ascorbic Acid treatment at 1000 mg.L - 1 and trice spray increasedsignificantly bunch weight , total yield, peroxidase activity of leaf and fruit, and catalase activity of leaf. Control treatment of bio - combination gave significant increases in fruit moisture content of the second season and total soluble solids of fruit .Results of protein pattern showed the occurrence of deferential gene expression in which a number of bands appeared on the gel were differed in numbers and location depending on type of treatments .

عزل وتشخيص بكتريا Bifidobacterium bifidum ودراسة تاثير نواتجها الايضية في الحفظ الحيوي لبعض منتجات اللحوم == Isolation and Identification of Bifidobacterium bifidum And Study The Effect Of Metabolic Products In Biopreservation Of Some Meat Products

اسم المؤلف: مصطفى علي كاظم علي الزبيدي
اسم المشرف: نوفل عبد الامير حسين الحلفي | خديجة صادق جعفر
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الاغذية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: In the current study were obtained Bifidobacterium isolates from soucers including (Human milk and feces of children aged 7 - 43 day) using the selective media MRS NLLP and through morphological , microscopical and biochemical tests including catalase test , production of CO2 gas from glucose test , gelatinase test , producation of ammonium from arginin test , nitrate reduction test and carbohydrate fermentation were obtained 8 bacterial isolates belonging to the genus Bifidobacterium Bifidum.then Conducted confirmatory diagnosis for 8 bacterial isolates using Vitek 2 compact system which stressed the ownership of four of them to bacteria Bifidobacterium bifidum.Metabolic products (Cell free supernatus )were prepared for local and standard bacterial isolates of bacteria Bifidobacterium bifidum and measured effectiveness inhibitory for metabolic products (full bacterial filtrate , bacterial filtrate after removing the effect of hydrogen peroxide, bacterial filtrate after adjusting pH ) Against four types of pathogenic bacteria and bacteria that cause spoilage of food (Staphylococcus aureus,Bacillus cereus ,Escherichia coli ,Pseudomonas aeruginosa) The results were as follows : 1 - All metabolic products prepared from local bacterial isolates for Bifidobacterium bifidum bacteria (Three bacterial filtrates) showed significant inhibitory ability against four types of test bacteria. and outperforming to the ability of inhibitory metabolites that prepared from the standard isolation Bb12, gram positive test bacteria (Staphylococcus aureus, Bacillus cereus) showed high sensitivity to (Three bacterial filtrates) of the local isolation MB6 in comparing with gram negative test bacteria Escherichia coli, Pseudomonas aeruginosa.2 - It was noted that the inhibitory diameter of Staphylococcus aureus was The broader to (Three bacterial filtrates) of local isolation MB6 where was (19 , 16, 14) mm respectively Compared to the other local bacterial isolates (MB1, MB3, MB7) superior on the inhibitory diameter of all metabolic products prepared from standard bacterial isolation Bb12 .3 - Metabolic products of local bacterial isolation MB6 showed High inhibitory ability against Bacillus cereus for All filtrates where wasthe inhibitory diameter (17.15, 12.5) mm respectively Compared to the other local bacterial isolates (MB1, MB3, MB7) superior on the inhibitory diameter of all metabolic products prepared from standard bacterial isolation Bb12 .4 - Escherichia coli showed sensitivity to metabolic products of local bacterial isolation MB6 (full bacterial filtrate , bacterial filtrate after removing the effect of hydrogen peroxide, bacterial filtrate after adjusting pH) ) where was the inhibitory diameter (14 , 13 , 11) mm respectively Compared to the other local bacterial isolates (MB1, MB3, MB7) superior on the inhibitory diameter of all metabolic products prepared from standard bacterial isolation Bb12 .5 - Results indicated that Pseudomonas aeruginosa was most resistant to all filtrates of the local bacterial isolates (MB1, MB3, MB6, MB7) and standard isolation Bb12 compared to other types of test bacteria , all filtrates of local isolation MB6 showed The highest inhibitory diameter where was (13.5, 12, 10.5) mm respectively Compared to the other local bacterial isolates (MB1, MB3, MB7) superior on the inhibitory diameter of all metabolic products prepared from standard bacterial isolation Bb12 .Metabolic product (full bacterial filtrate) for local bacterial isolation MB6 using as a natural preservative against bacterial activity to prolong the storage period to producers of minced meat tablets and Iraqi kebabs for a period of 15 days from the refrigerated storage at a 4 C° using four different concentrations (0.75, 1.5, 2.25 , 3) %, The results were as follows , results of the study showed a significant effect when added metabolic product for Bifidobacterium bifidum bacteria at (0.75, 1.5, 2.25 , 3) % concentrations during storage by cooling on averages of log number of bacteria (total aerobic bacteria , total coliform bacteria , psychotropic bacteria, proteolytic bacteria, lipolytic bacteria) where it was noted that the highest inhibition was at a concentration of 3% for all types of bacteria above respectively for samples of minced meat tablets and Iraqi kebabs. results of the current study, showed a decrease in values of total volatile nitrogen , Peroxide value, acid value with Significant differences as a result of the impact of added metabolic product for Bifidobacterium bifidum bacteria at (0.75, 1.5, 2.25, 3) % concentrations during storage by cooling for fifteen days

تاثير استخدام التبن المعامل بالشرش واليوريا بنسب مختلفة في اداء الحملان العزابية الدكزية == Effect of the Using of Different Rates of Straw Treated with Whey and Urea on the Performance of Male Arabi Lambs

اسم المؤلف: محمد صبيح مجيد مريوش الساعدي
اسم المشرف: عماد فلاح حسن الجاسم
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الحيوان
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: The present study was conducted at Animal Farm/College of Agriculture/ University of Basra during 20/11/2014 to 18/2/2015. The aim was to clarify the effect of using straw treated with whey and urea at different levels on some productive and physiological traits of male Arabi lambs. A total of 16 male lambs were used aged 6 - 7 months with an average weight of 30.50±1.65 Kg. the lambs were distributed randomly and equally to four treatments. Concentrate diet included barley (55%), wheat straw (43%), vitamin and minerals (1%), urea (0.5%) and salt NaCl, (0.5%). Lambs were fed at 3% of their live body weight with adjustment depending on body weight change through the study period to every treatment (every two weeks). The residual feed was collected every following morning to measure the consumption feed. Ration of each treatment was as follow : 1 - First treatment : 100% concentrate diet.2 - Second treatment : 90% concentrate+10% straw treated with whey and urea.3 - Third treatment : 80% concentrate+20% straw treated with whey and urea.4 - Four treatment : 70% concentrate+30% straw treated with whey and urea.The studied productive traits were live weight, daily and total growth rates, feed consumption and feed conversion ratio, carcass traits (hot carcassweight, dressing%, cuts weight, carcass offal, internal organs weight, abdominal, heart, kidney, pelvic and tail fat weight with physical dissection of rib cut and measurement of meat, bone and fat%). Organoleptic test included color, flavor, tenderness, juiciness and total acceptance. Blood biochemical traits included total protein, glucose, cholesterol, triglycerides, serum urea and some hormones as growth and thyroxine hormones. Results can be summarized as follow : 1 - There were significant differences in final body weight and daily and total growth rate of lambs of second group, which was fed 10% treated straw with whey and urea in comparison with other groups.2 - Significant improvement in feed conversion ratio of lambs of 2nd group in comparison with other groups as well as there was an increase in feed consumption of lambs of 2nd and 3rd groups.3 - There were significant differences in hot carcass weights of 2nd group in comparison with other groups as well as dressing% of lambs of control and 2nd group in comparison with other groups.4 - Lack of significant differences among treated groups in the cases of cut weights, weight and % of meat, fat and bone of rib cut, external body offal, internal organs and some body fat depots.5 - Significant differences in tail weight of 2nd group and abdominal fat of 2nd and 4th groups in comparison with other groups were observed.6 - There were significant improvement in some organoleptic test as flavor and total acceptance of groups received straw treated with both 10% or 20% whey and urea in comparison with control group.7 - There was a significant increase in total proteın concentration in blood serum of lambs of 2nd and 3rd group in comparison with other groups. There was also a significant difference in serum urea concentration of lambs of 2nd, 3rd and 4th groups in comparison with control group.8 - Neither signifcant differences were found in cholesterol, glucose, triglyerides nor in growth and throxine hormones among studeid groups.

تاثير موعد الزراعة وكثافتها وحامض السالسليك وتداخلاتها في نمو نبات الكزبرة Coriandrum sativum L. وحاصله من الثمار وفعاليته التثبيطية لبعض الاحياء الدقيقة == Effect of Sowing date, plant density and Salicylic acid in Growth plant coriander Coriandrum sativum (L.) and their yield from fruit and inhibitory activities of some microorganism

اسم المؤلف: ليلى تركي فضالة البدري
اسم المشرف: سميرة عبد الكريم مطرود | ماجد عبد الحميد ابراهيم
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات - البستنة
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: The present study was conducted during the growing season of 2015/2016 in the Medical and Aromatic Plants Unit Field, Collage of Agricultural, Basrah University, to study the effect of sowing date, plant density and salicylic acid in growth and yield of Coraiandrum sativum (L and its inhibitory activities of some microorganismThe study Includes 12 factorial treatments, which were the combinations of two sowing dates 1/10 or 1/11, two plant densities 25 plant m - 2 or 50 plant m - 2 and spraying with salicylic acid in concentration of 0 ,7.5 or 15 mg.l - 1. A Complete Randomized Block Design in a factorial experiment was used with three replicates. Treatment means were compared according to the Least Significant Differences Test (L.S.D) in level 0.05 was used to compared with Genstat programs. The most important results may be summarized as follows : - 1. Effect of sowing dates : Plants sown on 1/10 gave significantly increases in plant height, leaf number. Plant - 1, number of main lateral branches.plant - 1, dry weights of shoot system.plant - 1, length and dry weight of root system date to the appearance of the first inflorescence, the total number of inflorescences. plant - 1, total number of mini inflorescences plant - 1.total, the productivity of fruit. hectare - 1 (8.96 ton),oil yield.plant - 1 (0.893g), productivity of oil.hectare - 1 (330 kg), refractive index of volatile oil, leaves content of total soluble carbohydrates, leaves content of vitamin C and fruit content of total soluble carbohydrates. Whereas plants sown on 1\11 had a significant effect in total of mini inflorescences, and total protein percentage in fruit.2. Effect of plant densitycultivated plant at 25 plant.m - 2 had a significantly effect in leaf number.Plant - 1, number of main lateral branches.plant - 1 , dry weights of shootSummaryBsystem.plant - 1, length and dry weight of root system , , total number of mini inflorescences.plant - 1, leaves content of total soluble carbohydrates, fruit content of total soluble carbohydrates. cultivated plant at 50 plant.m - 2 had a significant effect in plant height, the productivity of fruit hectare - 1 (8.56 ton), productivity of oil .hectare - 1 (320 kg).3. Effect of salicylic acidPlant sprayed with SA at 15 mg.l - 1 had a significant effect in number of main lateral branches, dry weights of shoot system.plant - 1, dry weight of root, the total number of inflorescences.plant - 1, total number of mini inflorescences plant - 1. weight of 1000 fruit, , refractive index of volatile oil, oil density, leaves content of total soluble carbohydrates, fruit content of total soluble carbohydrates, total protein percentage in fruit. Whereas Plant sprayed with SA at 7.5 mg.l - 1 had a significant effect in leaf number.Plant - 1, length of root system, and the productivity of fruit.hectare - 1 (8.83ton).4. Effect of the interactionsThe Interactions between the study factors, showed a significant effect in most studied parameters.5. Effectiveness of alcoholic extracts and oil of the plant coriander against the two types of pathogenic bacteria to humanThe activities of methanolic and ethanolic extracts and oil of fruit were tested against some types of bacteria Escherichia coli and Staphylococcus aureus at three concentrations100, 200, or 400 mg.l. - 1 by using filter paper disc diffusion method. Each of ethanolic extract and oil of the fruits inhibition in concentrations 400 mg.l - 1, were effected growth of bacteria E. coli. They reached the diameter of inhibition 12 mm. Ethanolic extracts of the fruits at concentration of 400 mg.l - 1 gave the highest inhibition of growth of bacteria staph. aureus amount 12mm and E. coli the diameter of inhibition 10 mm.SummaryC6. Effectiveness of alcoholic exteracts and oil of the plant coriander against two pathogenic fungi to humanThe activities of methanolic and ethanolic extracts and oil of fruit were tested against types two fungi Aspergillus niger and Candida albican at three concentrations 100, 200,or 400 mg.l - 1. Was mathanolic extract of the fruits at concentration of 400 mg.l - 1 gave the highest inhibition of growth of A. nigerand C. albican amount 12mm and showed oil fruit and ethanolic extracts at concentration cultivated of 400 mg.l - 1 the highest inhibition against A. nigerand C. albican amount 10mm.

تاثير التعقيم مصدر الجزء النباتي ومنظمات النمو في اكثار نبات الكاردينيا المتقزم Gardenia jasminoides Ellis صنف Radicans خرج الجسم الحي واقلمتة == Effect of Sterilization, The Source of Explants and growth regulators on propagation of dwraf Gardenia jasminoides Ellis. cv. Radicans In vitro and Acclimatization

اسم المؤلف: لمياء حسين موسى عايش المازني
اسم المشرف: هدى عبد الكريم عبد الودود الطه
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: النبات - البستنة
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: This work was conducted in Plant Tissue Culture Laboratory, Agriculture Collage, Basrah University, Basrah Governorate, Iraq during the period 23/ October/ 2013 to 15/ March/ 2015. The aims of this study can be summarized to : (a) set up a protocol for establishment of sterilization techniques and effect the source of explants in micropropagation of dwarf gardenia (Gardenia jasminoides Ellis.) cultivar 'Radicans', (b) study the effect of different growth regulators auxins and cytokinins on multiplication and rooting of regenerants , and (c) set up a procedure for plantlet acclimatization .Results can be summarized as follow : 1. Contamination is first obstacle facing the micropropagation for dwarf gardenia. In order to overcome this problem, a sterilization procedure was developed as a base line to determine the relative effectiveness of various disinfectants which is described in this study. Observations indicate that only 26.60% healthy clean cultures was obtained when 40% of sodium hypochlorite solution used singly. But, when explants disinfected first with 40% sodium hypochlorite followed by treating with 0.1% mercuric chloride for 10 minute the percentage rate of aseptic cultures increased to 56.60%. Therefore, the successful protocol was adopted in this study.2. (a) Results revealed that High response to tissue culture , shoot numbers , length, leaf width and leaf numbers (100%, 1.30 shoots/explant, 8.4 - 1.55 cm and 2.66 leaves/explant respectively) were obtained when the shoot tips and nodal explants cultured on MS medium supplemented with 3 mg/L BA+ 0.2mg/L NAA+ 0.2mg/L GA3 each. While, maximumsuccessful response of nodal explant to tissue culture 80% and 100% was observed in MS medium enriched with BA 3 and 4 mg/L BA. However, granular callus was formed on the lower part of the nodes, but after a time this callus turned brown and hyperhydric (vitrified).(b) Maximum successful response of shoot tips in vitro 100% was noticed in MS medium enriched with different concentrations of TDZ 0.5, 1, 1.5 and 2 mg/L in the presence of NAA and GA3 0.2mg/L each, but the high rate of shoot number 1.8 and length 1.18 cm obtained on MS medium containing 1 mg/L TDZ. Where, the rate value of leaf width and numbers were increased only on MS medium fortified with low concentrations of TDZ 0.5 and 1mg/L. On the contrary, nodal explants cultured on same medium failed to responding, except the ones cultured on MS medium containing 1mg/L TDZ , showed moderate rate value of average growth responding66. 06%.3. (a) Results also revealed that the culture of shoot tips on medium supplemented with a combination of 3 mg/L BA, 0.2 mg/L NAA and 2 mg/L GA3 gave the highest value of average shoots number, leave number, and leaf width (2.50 shoots/explant, 6 leaves/plant and 1.7cm respectively). But, at this formula shoots became hyperhydic and leaves fall down. Whereas, highest shoot length 1.75 cm was recorded on MS medium enriched with 1 mg/L BA.(b) Highest shoot and leaf numbers and leaf width recorded on MS medium containing 1 mg/L TDZ in the presence of NAA and GA3 0.2mg/L each 4.33 shoots/explant, 6.00 leaves/ explant and 1.30 cm respectively. Whereas, highest shoot length 1.50 cm recorded on MS medium fortified with 0.5 mg/L TDZ. However, small amount of white brownish callus raised around the nodes grown on medium containing 0.5 mg/L TDZ, whilebig amount of the same callus was recognized around the nodes grown on MS medium containing 1.5 mg/L TDZ.4. (a) The present study has revealed that abundant primary callus formation (100%) could be achieved only from young leaf segments (basal and middle segments) within 10.3 and 15.3 days in MS medium containing 3 mg/L 2,4 - D and 0.2 mg/L BA, and under dark conditions.1) Transferring the primary callus to MS medium enriched with 3mg/L 2,4 - D for 8 weeks under light conditions led to induce somatic embryos, that can be identified by their nodular consistency and green color.2) While, shifting the primary callus to MS medium enriched with 3 or 5mg/L BA + 0.2mg/L 2,4 - D led to converting the primary callus to compact callus, and at the end of incubation period, small adventitious shoots was generating.(b) Results also showed that white brownish granular callus initiated under dark conditions on the base of the leaf petioles (basal segment) explants grown on MS medium containing 5 mg/L BA+0.2mg/L NAA, then the callus increased to covered whole explant during the end of incubation period. However, adventitious shoots was generated from primary callus when shifted to MS medium fortify with 1 or 2 mg/L BA. Results also revealed that the middle segment of the leaf explants failed to form callus on MS medium containing different concentrations of BA used in this study.(c) It was observed that in vitro shoots segments 1.5 cm length produced 100% callus on 1/2 MS medium enriched with 8 mg/L NAA within 8 - 9 days of inoculation. However, transferring this callus to full strength of MS medium supplemented with 1 or 2 mg/L BA led to generating small green adventitious shoots.5. (a)Maximum root formation rate 100% with high number of roots 7.33/plantlet, root length 7.33cm and number of secondary roots (8.00/ main root), were obtained within a short period 13.33 days Also, it was found that the length of shoots and number of leaves were increased to 12 cm and 11.33 leaves/plantlet, respectively.(b) On ½MS medium containing different concentrations of NAA 2, 4, 6 and 8 mg/L in the presence of 0.2mg/L BA, adventitious roots formed with rate 100%. These roots emerged indirectly from the edge of shoots with callus induction phase and developed into white thick and wide roots which grew and branched inside medium. However, maximum value of morphological traits for root was obtained when the shoots grown on MS medium containing 8 mg/L NAA in the presence of 0.2mg/L BA, while the less period of root formation was recorded when the NAA concentration decreased to 2mg/L.6. Two procedures of acclimatization have been attempted to obtain full healthy plantlets ex vitro. Results showed that the soaking of rooted plants for 10 - 14 days in pure water, nearly 60% of plantlets were survived. Whereas, treated the plantlet with 2% PEG 6000 before transplanting to soil increased the survival rate to 100%, Also this concentration of PEG was decreased the precentage of wather loss from leaves of gardenia plants through the acclimatization stage 12.8%.

تاثير احلال نسب مختلفة من مجروش نوى التمر محل الشعير مع او بدون اضافة خميرة الخبز (Saccharomyces cerevisiae) في اداء الحملان العرابية الذكرية == Effect of replacing different ratios of crushed Date Stone instead of barley with or without addition of Saccharomyces cerevisiae on performance of Arabi Male Lambs

اسم المؤلف: كريم حمادي مهنى ابو سلوى
اسم المشرف: محارب عبد الحميد طاهر | عـماد فلاح الجاسم
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الحيوان
الدرجة: دكتوراه
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: This study was conducted in the Animal Farm of the College of Agriculture - University of Basrah. A total of 28 Arabi male lambs were used, with average age of 5 months and mean body weight of 21.74 ± 1.33 Kg. Lambs were distributed equally and randomly into 7 nutrition rations in two experiments. First experiment was a growth experiment which lasted for 90 days. The second was digestion field experiment and lasted for 13 days after the end of the first experiment. The experimental rations were as follows : Ration - 1 - (control) - fed on concentrate ration only by 3% of body weight. Ration - 2 - fed on 90% of the control ration and 10% of ground date stones substituted for the barley.Ration - 3 - lambs fed on the ration 2 with addition of 3 grams of bakery yeast (Saccharomyces cerevisiae) / Kg of feed. Ration - 4 - fed on 80% of the control ration with substitution of 20% of date stones for barley.Ration - 5 - lambs fed on the ration 4 with addition of 3 grams of bakery yeast per Kg of feed.Ration - 6 - fed on 70% of the control ration and 30% of date stones.Ration - 7 - lambs fed on the ration 6 with addition of 3 grams of bakery yeast per Kg of feed.Results were as follows : 1 - Mean final body weight (34.00 Kg) except Control ration, total gain weight (12.75 Kg) except the control and 2 rations and daily gain weight (141.67 g/ day) of lambs in ration 3 were significantly higher than animals in other rations.2 - Animals of ration 3 recorded the highest feed consumption arithmetically (0.829 Kg/ day/ lamb) and the best feed conversion ratio arithmetically too (5.85 Kg dry matter/ Kg body weight gain).3 - Substitution of date stones with addition of bakery yeast affected digestion coefficients of feed nutrients. Ration 3 was superior in digestion coefficients of dry matter, crude protein and nitrogen free extract to other rations. These values were 70.64, 72.11 and 80.64 %.4 - Results showed significant differences between means of pH of rumen fluid and total bacterial count which Significant decreases in each of 6 and 7 rations than other rations while in the counts of cellulolytic digestion bacteria, ration 3 were significantly than animals in other rations but not differ significantly from that of the ration 5 while it was similar with control ration. 5 - No significant differences between rations were noticed in means of red blood corpuscles, white blood cells, hemoglobin, packed cell volume, cholesterol concentration, glucose concentration and concentration of the enzymes GPT and GOT. While differences between means of blood urea concentration and total protein of blood were significant.6 - Mean empty body weight, hot carcass weight, dressing percentage on the basis of live weight and empty body weight of lambs in ration 3 28.02 Kg, 16.18 Kg, 47.59% and 57.74% respectively were significantly higher than that of animals in other rations except control ration in hot carcass weight.7 - The highest weights of rib cut (rib 7 - 12), leg cut and loin cut were for animals in ration 3 (1.61, 5.00 and 2.40 Kg respectively) than other rations but in the loin cut, the ration 3 was similar to the control ration 2.16 Kg.8 - For body measurements, the highest leg circumference were recorded for animals in rations 2 and 3 (35.00 and 36.50 cm respectively) than other rations but these rations were similar to the control ration. While the highest rib eye muscle area was for carcasses of animals in ration 3 (14.41 cm2) but this value did not differ significantly from that of the control animals (13.45 cm2).9 - In the case of some carcass muscle weights, the muscle Supraspinatus weight were higher in the animals of the ration 3 (176.67 g) but it was similar to control ration (164.25 g). Weight of the muscle Biceps femoris was higher in the carcasses of animals in ration 3 (625.75 g).10 - Carcasses of animals in ration 3 recorded the highest dissected lean meat 931.70 g and fat 280.55 g in rib cut, but no significant differences were registered for dissected bone weight among the different rations. Also weights of the internal organs of the animals namely : liver, heart, kidneys, lungs, spleen and the testicles for animals in ration 3 were higher than that of other rations.11 - Mean weights of separated fat of carcasses were higher for animals of the 2 and 3 rations (1.93 and 1.95 Kg respectively) in comparison with animals of other rations but these rations were similar to the control ration 2.08 Kg.12 - Substitution of date stones in percentages of 10% and 20%, with the addition of bakery yeast caused significant improvement in organoleptic characteristics (color, tenderness, juiciness and overall acceptability). Evaluation of samples of rations 3 and 5 were superior to that of other rations.13 - Rations 3 and 5 gave the best results for water holding capacity in meat. No significant differences were obtained in cholesterol concentration and pH of meat.Results showed that the lowest values of cooking loss were in ration 3 (43.30 %).No significant differences were observed in chemical composition of theLongissimus dorsi muscle (moisture, protein, fat and ash) between rations.

دراسة التنوع الوراثي للجاموس العراقي باستخدام تقنيتي RAPD وSTR == Study of Genetic Diversity of Iraqi Buffalo by RAPD and STR

اسم المؤلف: فالح حسن حمد
اسم المشرف: اسعد يحيى عايد | طالب احمد جايد
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الحيوان
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: The current study was conducted in the laboratory of Dr. TalibAhmed Jaayide Molecular Genetics / Faculty of Agriculture /University of Basrah. After collecting blood samples from the Iraqibuffalo in the provinces of Basrah (30 samples), Dhi Qar, Maysanand Najaf (25 samples each), bringing the total samples to 105samples. The study aimed to study the genetic diversity of the Iraqibuffalo through the use of tow techniques, first technique was, thePCR - RAPD technique and the second microsatellite technique(PCR - STR). After extracting the DNA samples, seven primers ofPCR - RAPD technique were used, included C01, C04, C06, C07,C09, C11 and C12. Primers of PCR - STR technique wereILSTS005, ILSTS029 and ILSTS072. After analyzing the results ofthe three technologies it can be summarized as follows : 1 - All primers of PCR - RAPD showed genetic polymorphisms,with the presence of many bands except the primer C11which was notamplified in all samples.2 - The size of primer C07 was 1969 bp, which was the biggestprimer size, however, the smallest primer size was C01(1606 bp).3 - Number of bands showed by PCR - RAPD primers were 28,42, 56, 53, 57 and 64 bands of C01, C04, C06, C07, C09,C12 primers respectively.4 - Primer C09 revealed the highest number of polymorphicbands in Basra and Dhi - Qar provinces (47 and 46 bandsrespectively). However, the primer C12 gave highest numberof polymorphic bands in Maysan (47 bands). The primer C01showed lowest number of polymorphic bands in all studiedprovinces (14 bands in Basra and Dhi - Qar provinces, 12bands in Maysan and 13 bands in Najaf province.5 - Shared bands between Basra and Dhi - Qar, Basra andMaysan, Basra and Najaf, Dhi - Qar and Maysan, Dhi - Qar andNajaf and Maysan and Najaf were 177, 151, 162, 146 and152 bands respectively. The high number of shared bandsreflected high genetic similarly among provinces.6 - Maysan province showed highest special bands of primerC07 (8 bands) followed by Dhi - Qar province (5 bands) whichis considered as fingerprint for these provinces even they showed very low frequencies.7 - Primer C04 revealed lowest genetic diversity measured by Shannon index in all studied areas (28.82 - 35.58%), however, all other primers showed higher genetic diversity (47.57 - 55.70%).8 - Similarity among provinces was higher than 70% to 95% for all PCR - RAPD primers, which indicates that all subpopulations of buffalo belong to one breed.9 - Primers C07 and C12 highlighted highest percent of mean gene diversity to population diversity (GST) with a value of 22.69 and 21.46 respectively.10 - All STR markers (ILSTS005, ILSTS029 and ILSTS072) have been amplified in all buffalo samples of all studied areas. Observed allele numbers were 20, 22 and 21 alleles for markers respectively with a total of 63 alleles. The marker ILSTS005 gave highest number of observed alleles in Dhi - Qar (21), Najaf (20) and Maysan (17). Whereas, the marker ILSTS029 showed less number of observed alleles at Maysan province (9 alleles). 11 - Allele frequencies ranged from 0.02 to 0.32 for all markers and provinces.12 - Shared alleles between Basra andDhi - Qar, Basra and Maysan, Basra and Najaf, Dhi - Qar and Maysan, Dhi - Qar andNajaf, Maysan and Najaf were 25, 27, 30, 22, 33 and 33alleles.13 - Special allele mean frequency of studied population was 0.048. While gene flow after adjusted for sample size of each province was 2.25 alleles. Range of missing allele frequency for all studied areas was 0.000 - 0.099.14 - Range of heterozygosity percent was 80 - 100%, whereas homozygosity% was 0 - 20%.15 - All Fis values of studied markers in all provinces were significant except the marker STR072 in Dhi - Qar province which was nonsignificant. This result reflected the absence of inbreeding in all areas and there was no significant deficiency in genetic variation.16 - Linkage disequilibrium test showed that tested markers are not located on one chromosome.17 - The study thus highlights the usefulness of heterologous PCR - RAPD and microsatellite markers to assess the genetic variability in buffalo. Also various diversity indices suggest sufficient genetic variability within Iraqi buffalo that can be utilized as initial guidelines for future breeding strategies and conservation.

التشكيل الوراثي لجين FASN وعلاقته لانتاج الحليب ومكوناته في سلالتي الابقار الجنوبي الفريزيان == FASN Gene Polymorphism and its relation to the production milk and components in the ALJnoby cattle breeds and friesian

اسم المؤلف: غفران ماجد عزيز مارد النيازي
اسم المشرف: اسعد يحيى عايد
الموضوع العام: علوم الزراعة
السنة: 2016
الموضوع الدقيق: الحيوان - التربية
الدرجة: ماجستير
الجامعة: جامعة البصرة
اللغة: العربية
مكان الجامعة: البصرة
الصفحات الاولى:
المستخلص: Atotal of 60 cows belong to freisian local Iraq breed (30 each ) were used in the cow for aperioed of 1/12/ 2012 to 30 /3 /2015 cows were from local breeders within Thi - Qar provin samples were callectted from each animal one hrough study period . After measuring milk asmples of 50 ml were taken to estimate fat , protein and some other milk composition as Well as fatty acid composition were estirm from extracted fat Besides that blood samples from each animal were taken to extract agene was amplicied cat in to different results can be summarized as follow : 1 - FASN gene has been amplified and there were identified .Genotypes were AA,AG and frequency of 0.13 ,0.54 and 0.33 respeccfin freisian breed and 0.47 ,0.33 and 0.16 of A and G alleles frequencies were 0.40 and 0.60 of freisian breed and 0.65 and 0.35 of local breed respechlivy the two population were at aqulibirium .2 - Breeds showed similar obsereved number of alleles (2) observied herrozygosity differe between breeds (53.3% and 36.5 for freisian and local breed respectively ). AHowver showed similar expected heterozygosity (48.81 and 46 .27% respectirely ).3 - AA and GG genotypes excceded the genotype AG by daily and total milk yield of freisian breed . they produced 2968.90 and 2809.80 kg total milk yield respectively .AG gene produced only 2645.54 kg .4 - AA genotype of freisian were produced significantly higher fat and protein (97.10 and 100.05 kg respectively ) that of other genotypes .As well as AA and AG genotypes produced singnificantly higher fat% (3.27% and 3.29% respectively ) in comparicer with 3.17% of GG genotypes the AG genotype produced highest protein% (3.4170)in comparison with other genotypes.5 - AA genotypes of local breed exceeded other genotype in producing daily and total milk yield ,fat and protein.on contrary ,GG genotype yielded higher fat %(4.2) in comparison with that of other genotypes AA and GG genotypes have got highest level of protein (3.25 and 3.30% respechvely ) in comparison with 3.20% AA genotype .B6 - Only AG and GG of local breed were strain in the registration of fat content protein within the standard range ,wich is 1.23, 1.27 respectire .7 - Daily milk breeds value s. recorded negative breedes values.there was an indicater that A allele has positive effecf on daily milk yield .hower A allel has negative effect.8 - A allele has negative effect on fat % in milk cows consequently genotypes have this allele (AA and AG) had negative breeders values. On the other hand ,AG and GG genotypes of local breed had negative breed ing values .9 - GG genotypes of both breeds had positive protein % breeding value ,although its breeding value was nearly zero .10 - GG genotype of Friesian breed produced higher palametic and oleic fatty acids than those of AA and AG genotypes . whereas , AA and AG genotypes produced highes level of palametic and total saturated fatty acid .11 - Genotypes of FASN gene of local breeds did not show significant differences amang all types of milk fatty acid .12 - Freisian exceeded local breed to quantity and quality of milk specially fatty acid composition that has positive effect on human health.C
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