Author name:
رواء هادي شريف
Supervisor name:
سامي رحيم الكاتب | احمد نعمة رجيب
University location:
Najaf
Abstract:
امراض الشرايين التاجية السبب الرئيسي لمعظم حالات العجز والوفاة في الدول المتقدمة. العمر, الجنس, السمنة, اختلال مستويات الدهون, التدخين, ارتفاع ضغط الدم, مرض السكر, الالتهابات, والاكسدة الضارة من اهم عوامل الخطورة الرئيسية للمرض. مجموعة من الدراسات اوحت ب | Coronary artery diseases are the most important causes of mortality and morbidity in many developing countries. Age, gender, obesity , lipid disturbance, smoking, hypertension, diabetes mellitus, inflammations and oxidative stress are considered as major risk factors of disease. Many of studies suggest that there is association between blood groups and risk factors of coronary artery diseases.Objective : The aims of study are to find if there is an association between blood groups and CADs and to study some of the causes that may be lead to this association. Also, it aims to determine the type of relation between some important factors such as, C - reactive protein (CRP), advanced glycation end products(AGEPs), and glutathione peroxidase - 3 (GPX - 3) with blood groups and coronary artery diseases. Materials & Methods : Ninety persons included in the study (60 as patients and 30 as healthy controls). Where the patients suffering from CAD, the controls are free from this diseases. Their ages ranged between 25 - 70 years old and they were divided into four groups according to the blood groups (A, B, AB, and O). This study is based on case control study done in Al - Sadder Teaching hospital (Cardiac Center) in Al - Najaf Al - Ashraf city from December 2012 - to October 2013. Some information were taken from each person in the study like, name, age, sex, address, weight and height. Finally and after getting permissions, the blood group was analyzed for each person in the study, then the sera were collected from those 90 persons and analyzed by using enzyme linked immunosorbent assay (ELISA) for CRP, AGEPs, and GPX - 3, meanwhile for lipids assay we used spectrophotometer. Results : The results of the study show that the blood group O( 33.7%) predominates in both studied groups (Patients and controls) followed by A (29.6%), B (27.4%), and AB (9%). There is no significant differences in the percentage of blood groups between patients and controls groups (P >0.05). Also, the results of the study show that the incidence of disease increase with age increases and in male (80%) more than female (20%). Also, the results show that only patients group has obese individuals and most obese were from blood group B(80%), followed by A(66.6%), O(60.8%), and AB(50%). The statistical analysis of the study shows that blood group AB among patients and blood group B among controls have a significant increasing (P<0.05) in the serum level of total cholesterol, and C - reactive protein (CRP). While, the results show that blood groups (B&AB) of patients have a significant increasing in the serum level of triglycerides. The blood group A among patients and blood group B among control show a significant increasing in the LDL cholesterol serum level, while blood groups (A& B) of patients have a significant reduction in the serum level of HDL cholesterol. Also, the study shows that blood group A of both patients and controls has a significant increasing in the serum level of advanced glycation end products (AGEPs), while the blood groups (A& B) of patients have a significant decreasing in the serum level of glutathione peroxidase - 3 (GPX3). Finally, the results of the study show a negative correlation (R= - ) between AGEPs and GPX3 in blood groups ( B&O) of both patients and controls group.Conclusions : Results of the present study show that the blood group O predominates in the studied groups in Al - Najaf Al - Ashraf city followed by A, B, and the last is AB. The incidence of CAD 2 to 4 time more common in male than female and incidence of CAD increase with age increases in both sex. The incidence of CAD 2 to 4 time more common in male than female and incidence of CAD increase with age increases in both sex. Also, There is a high percentage of subjects from blood groups (A, B, and AB) suffering from disturbance in the serum level of lipids and high level of CRP, which they were associated with atherosclerosis disease that was considered one of the most important leading cause of CAD.
