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المتخلفون عن الجهاد في القران الكريم والحديث الشريف : دراسة موضوعية The crippling of striving duty in Holy Quran and in the Hadith Objective study

المستخلص: ان الجهاد في سبيل الله ضرورة من ضرورات الدين ولازمة من لوازمه شرعه الله سبحانه وتعالى لاعلاء كلمة الاسلام واقامة احكامه والقضاء على الظلم والاستبداد.فقال في محكم كتابه : ﴿ وما لكم لا تقاتلون في سبيل الله والمستضعفين من الرجال والنساء والولدان الذين يقولون ربنا اخرجنا من هذه القرية الظالم اهلهوااجعل لنا من لدنك وليا واجعل لنا من لدنك نصيرا ﴾( ).وان ترك هذه الفريضة يؤدي الى هدم الدين ونسفه من قواعده وتمكين اعداء الاسلام وتسليطهم على المسلمين ليعيثوا في الارض الفساد ويهلكوا الحرث والنسل.والناظر الى احوال الامة الاسلامية اليوم وما هي عليه من الضعف في الايمان والركون الى الدنيواالتواكل والتخاذل يدرك غياب هذه الفريضة عن اذهان الكثير من المسلمين، لولواجود القلة القليلة المؤمنة الصابرة لعطلت وصارت تراثا.ان الاثر المترتب على تعطيل فريضة الجهاد في سبيل الله كبير غفل عنه الكثير من عامة الناس واستخف به بعضهم لانشغالهم بالمعاصي وحب الدنيواتغافلهم عن اداء الواجبات التي فرضها الله عليهم.وباعتبار ان التخلف عن الجهاد من المسائل الابتلائية المعاصرة التي نعيش اثرهواكوارثها على الدين والفرد والمجتمع، اردت في هذه الدراسة ان ابين من هم المتخلفون عن الجهاد في سبيل الله وما هي صفاتهم التي ذكرها القران الكريم واكدها الحديث الشريف، وما هي اسباب تخلفهم عن الجهاد واثاره في الدنيواالاخرة، واعني هنا الجهاد بالنفس والمال اذهمرافيقان لا يفترقان، فالنفس والمال اعز ما يملك الانسان وغالبا ما يشح ويبخل بهما. | The striving in the sake of Allah is a necessity of religion necessities and Allah's law Almighty to raise the word of Islam, set up its provisions, and eliminate of oppression and tyranny. Allah said in The Holy Quran (So why is it, that you do not fight in the way of Allah, and for the abased among men, women, and children who say : 'Our Lord, bring us out from this village whose people are harmdoers, and give to us a guardian from You, and give to us a helper from You)And leaving this duty leads to the destruction of the religion, blew it out of its bases, empower the enemies of Islam, shed them on Muslims, make corruption in the earth and destroy plowing and offspring. Who lock at the conditions of the Islamic nation today and their weakness in faith, go with the temptations of this world and weakness all that resulted to the absence of this duty of Muslims mind. Were it not for the presence of the fewer patients who believe in this duty, it have become disrupted and have become a heritage.The consequence of crippling the striving duty in the sake of Allah is major, many the public have overlooked it and underestimated it by some for their preoccupation with sin and temptations of this world and them regardless of the duty mad by Allah.The crippling the striving duty consider as one of modern anguish issues that we live its consequences and effects on religion, personal and society. I wanted in this thesis to bring to light who is crippling of striving duty in the sake of Allah and thems characteristics mentioned in Holy Quran and Confirmed by the Hadith, and the reasons behind them crippling of striving and its effects on this live and the lastI mean by striving in this thesis the Self - striving and Money considering these tow as along together not get apart, self and money are best of a person have and mostly be scrimp by them.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الحديث
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: مياس ضياء باقر القزويني
اسم المؤلف: حسناء عبد الجبار علي الموسوي

منهجية التخطيط في تنمية الابداع من المنظور الاسلامي : دراسة فكرية mathadology planning in Development creation from Islam viwer of view thoughtful study

المستخلص: The idea of planning appeared the early time of founding Islamic state in Al - Madina Al - Munawara by prophet Muhammed (PBUH) when he set true and practical plans since the beginning of prophecy up to its end .He set targets ,priority and needs to achieve aim due to legality of mild sharia.While I was studying planning and creation according to Islamic point of view . I was many signs in the holy Quran and Sunna hadiths which are so clear about creative planning .Good planning requires suitable thoughts , logic and real events .We recommend to study Islamic culture to know about famous Islamic figures in different aspects of life . Holding conferences and seminars. Starting training classes and workshops in universities and research centers about planning and developing creative thoughts for the society .Educational foundations should pay more attention to improve the ability of their official to be on the truck .Finally , it would like to think all people who stood with me and give me a hand in the subject .Ahmed Al - NuaymiIn the name of Allah , the most gracious and the most compassionatePraise by to Almighty Allah and peace be upon his messenger plisses be upon his household esteem followers .Achieving success in any field of the require creative planning . It is the best way to specify the target by either a person or an organization to make decisions and start projects . This must be go together with creed thoughtful planning represented by faith and destiny and true dependence upon almighty Allah , Islam encourages us to set creative plans in all fields of life .Planning in the result of creation which lead to activity , production and efficiency in performance. Creative planning is the essential entrance to improve organizations and other foundations in any country . Absence of a creative planning leads to failure.Our religion Islam , urges us to you our brains and give them an opportunity to plan and create a new thoughts .There is a great connection between and creation this subject consist of : Introduction , four chapters and conclusion .The first chapter deals with regular planning , its importance , subjective , kinds , factor , obstacles and fundamental planning in Islam , Its legality from the Quran , Sunnah and dependence books .The second chapter explain the meaning of planning and its importance , Phases , levels , theories
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: دكتوراه
الموضوع الدقيق: اصول الدين
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: رعد حميد توفيق البياتي
اسم المؤلف: احمد صالح احمد النعيمي

مباحـث الالـهيات في ضـوء تـفسيـر ابـن عـرفـة : دراسة مقارنة Interpretation of Ibn Arafa (Comparative studies)

المستخلص: All praises are due to Allah We praise Him We Seek His help We seek His forgiveness and we seek His guidance. This study deals with goddesses research in terms of interprctation of IbnArafa / comparative study . Ibn Arafa : Muhammed bin Muhammed bin Arafa AL - Warghamy , ideologica / Maliki , the place of his birth is Tunis in 716A.H . Ibn Arafa was born in a very stable political period under the authority of AL - Hafsiahstate , received his first education by his father who was very Famous at that time. Then , he took his education from other scholars of his time.He administrated the schooling and spent his life in service of science . He Wrote Many refereuces in different fields of (IbnArafa interpretation ) which spread in different aread of Islamic world.IbnArafa was died in 802 A.H . The present thesis consists of three chapters and the results of the study . In introduction : The thesis presents the importance of the to pic and the reasous of selection of this study and the previous studies and the difficulties which face the researcher during the period of writing . Then pedogogical concepts and the plan of this study.The First chapter shows the era of AL - Immam Ibn Arafa and his scientific and personal life ,Morever , this chapter also shows the interpretation of the research and its references . The Second chapter is considered the Most importance chapter in the study . This chapter is divided into two subcategories , the first shows the points of views of AL - Immam IbnArafa in faith of Allah and the relations between surface structure and deep structure . The second category includes the oneness of Allah . The third chapter indicates qualities and deeds at Allah which are adopted by IbnArafa . This chapter into six sub categories because of its necessity .So , this chapter includes qualities types meaning qualities , predicated qualities , Allah,s speech , fate and destiny , the results May be the thesis dealt with . The imam Ibn 'Arafa (may Allaah have mercy on him) proved the personal and actual qualities without distinguishing between them in saying that they are silent. In the attribute of speaking to Allaah, he said that it is one meaning, an old one, not a letter or a voice. The old, and the vision of God has a reward of mind in the Hereafter for the believers without a body and no interview or how. It is obligatory to carry the word of Allah, and the words of His Messenger (peace and blessings of Allaah be upon him) on the apparent initiative of the mind with the purity in the attributes of God (Almighty) that the similarity characteristics of the qualities of the creatures, and this rule is not specific qualities, but also others.I ask Allah to forgive me for My shortcomings and to guide Me to the straight path
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: العقائد
السنة: 2017
الموضوع العام: العلوم الاسلامية
اسم المشرف: وضاح كافــي حــلــومــي
اسم المؤلف: مــحــمــد عادل مــســعــود مــحــمــد

الصيرفة الاسلامية واثرها في انشاء سوق مالية اسلامية Islamic Banking and its effect on establishing an Islamic financial market

المستخلص: These studies focus on several aspects of Islamic banking and the challenges it faces in the context of the contemporary reality in which it is operating. It deals with the state of the market and the transactions taking place in it, and the role of banks in the establishment and development of the Islamic financial market; It is known that the financial markets are revolving with banks and non - existent, money markets are one of the most important areas developed in dealing with all the channels in which money flows between different sectors of society and its members, and is concerned with the banking industry aimed at developing Find alternatives, and address developments.Since the success and evolution of the financial markets, depends closely on the diversity and evolution of the financial instruments in circulation; it is called for : intensifying efforts, coordinating them and promoting the development and creation of Islamic financial instruments, in accordance with Sharia law. , which expands and activates the Islamic financial market; It is activated and activated. It complements and contributes to the development of Islamic banking, on the one hand, and works to boost economic growth in Islamic countries on the other.As the local banking arena is witnessing, regional, and international, is a huge development in the Islamic banking industry, in the form of the creation of Islamic banks, or by turning some banks into Islamic banking, as well as providing many Local and international banks of Islamic Banking services, besides the services of the traditional bank, this development in the Islamic banking market has been accompanied by a similar development in Islamic means of investment provided to customers in Islamic banks; to arrive Currently more than 20 investment instruments used by Islamic banks.Hence the need to highlight the role that Islamic banks can play in supporting Islamic financial markets. and development; it is one of the most important investment outlets that absorb its surplus liquidity and provide it with sufficient cash at Need, and fund their projects and ideas
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: دكتوراه
الموضوع الدقيق: الاقتصاد الاسلامي
السنة: 2017
الموضوع العام: الادارة والاقتصاد
اسم المشرف: احمد سامي شوكت اركان يوسف حالوب
اسم المؤلف: جمال مهدي صالح

السلطة القضائية ودورها في الالزام بالاحكام الشرعية نماذج تطبيقية : دراسة مقارنة Jurisdiction and the extent of its authority in applying Sharia rulings between applicants and those who are late A comparative study

المستخلص: In the name of of Allah the MercifulThe jurisprudence in the religion of God is the greatest and so yes to God on his slaves, according to the student of jurisprudence the prphet said (peace be upon him) : (who responds to God good understanding of religion.The word of the people of science has agreed unanimously that the most honorable science and the greatest of good and useful, the science of jurisprudence and the blessings of the blessed and blessed by the security of the student science that the people who ask forgiveness of angels, even whales in the sea.And the hope to be included in this great credit and good general I chose an important jurisprudential issue of the doors of Islamic jurisprudence, which is the door of the judiciary, this magnificent door, whose owner stands on the brink of fire.Ibn Daqeeq al - 'Eid (may Allaah have mercy on him) said : "The symptoms of the Muslims are a hole from the pits of the fire and two groups of modern people and the rulers stood on their lips".After consultation with the people of credit from my teachers, may God have mercy on them all, the option was signed to the following address : the judicial authority and the extent of its authority in the application of the legal provisions between applicants and late - - a comparative study.It is not afraid of any one of the people, as well as the scholars of what occupies the position of the judiciary of the status of high, and high status, especially with its dissolution of disputes, and the lifting of disputes, and the establishment of rights, and the payment of grievances, and the establishment of borders and alienations.There is no doubt that there is a need for renewed study of this important subject, because the judiciary is not free from the need for a time or place, noting the frequent developments and facts to eliminate the word chapter.The nature of the research on this subject required that the thesis be in an introduction, four chapters and a conclusion.BAs for the introduction, it showed the importance of the subject, the reasons for its selection, and the researcher's plan and methodology in the research.The research methodology is based on the following : - I mentioned the Quranic verses mentioned in the research by mentioning the name of the surah and the number of the verse. - I have completed the conversations and the effects contained in the folds of the thesis, if I found it in the correct, or in one of them, I mentioned the part, the page, and the number of the Hadith or the impact, the book and the door, although others reported the rule of Hadith and impact of the books of graduation as much as energy and energy. - mention the evidence of the jurisprudential question if any of its parachutes. - Adopted in the transfer of each doctrine on its original sources, and did not transfer the issue of none of the books of their owners. - When mentioning the source or reference for the first time write the name of the book, and then the name of the author only short, but I will mention in detail in the glossary of sources and references. - I explained the strange word of the lexicons of language and jurisprudence, mentioning the doctrinal terminology of the books of doctrines and books of definitions of terminology. - We mention in every question the jurisprudence of the sayings of the jurists and some of the evidence, because the expansion in the mention of evidence will expand the research very disproportionate to the purposes of the title of the subject to highlight the role of the judiciary. - I have done my best in reviewing the sayings of the jurists, so that they will come forward and present them with the help of the writings of our contemporary scholars in order to reach the correct view according to the situation and the energy. - As to the conclusion, I briefly mentioned the main findings and the proposals I have reached. - Names of sources and references in the last search according to the alphabet
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: دكتوراه
الموضوع الدقيق: الفقه المقارن
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: جمال ابراهيم حمادي
اسم المؤلف: فاضل محسن صيهود

الاحاديث الواردة في تفسير التسهيل لعلوم التنزيل لابن جزي الغرناطي : دراسة وتخريجا من سورة الصافات الى اخر سورة الناس Conversations contained in the interpretation ( Facility for Science download) to the son rewarded Granada - Study and Takrija - from Saaffat to another Surah people

المستخلص: And prayer and peace be upon God's mercy mission to the worlds and his family and his companions and followers and followed them until the Day of religion, who raised Manar guidance and carried the banner of the year and Oalo like the novel and surrounded the sayings of the prophet fencing of the maintenance and care Vnfoa by misrepresentation Algalin and impersonating wrongdoers and interpretation of the ignorant.After : is not done wrong in the hands of his successor by God guides those who follow His good pleasure to ways of peace and brings them out of the darkness into the light with his permission, and guide them to the straight path.Then all the Almighty to His Messenger secretary illustrate this bookThe Koran treasure Asfha every era of his tools to take what he could from Jawahrh and Drrh, which gave the more Asttar cream,.2The different authors phrases and crafting of the texts and their dependence on different evidence from the Quran and Sunnah and scholarly and assets of interpretation known to have contributed effectively in our need for science concerned with these compositions on the one hand externalized and adjust the read and judge the evidence and the interpretation of some of its expression in a modern style fits with an understanding of people and their needs.Hence the importance of science graduation and study the grounds, which means a statement of out modern Moadah of it, and the study, evidence of extensive study governs from which to speak, and this flag meant all the arts people talk has been interested in studying the sayings of the books of fiqh, assets and faith, history and even wrote chips, literature and other of ancient and modern science, it was written explanation frontrunner in this section scientists have expressed their interest in books of interpretation arose, scholars study the conversations contained therein and externalizedIt is for this not complete the honor of the nation, but the Holy Quran and Sunnah The work of the commentators for this travel and their Tafseers Vnaloa honor precession rounded to two flags sketching two Tafsir and Hadith Both are school graduating imams workers and scientists dedicated on the back of these simple old The newly until God inherits the earth and them.A committee of professors virtuous entrusted me to study and the graduation of the conversations contained in the interpretation of3Ibn rewarded service for this book Galilee. Hence we recognize the importance of this great effort made it the world mark / The book "The easing of science download," wrote the task of interpretation, and you who won the honor, it was my share is the study and the graduation of the conversations contained in the interpretation of Ibn rewarded from Saaffat to Surat people and this is something that from God by Ali, he has created ways to forensic science and pleased me his ways and Ovgueni to join Besroha and tapping into the headwaters, at the hands of his family and his campaign from the Senate and professors adults.Importance of the issue and the reasons for his choice : It is summarized as follows : .1contribute to the Sunnah service, which is one of the strongest pieces of evidence cited by commentators in the course of their interpretation of the Qur'anic text.Scientific 2.agaymh of the book, which for the Islamic sciences for it.Scientific stature and fame among scientists.3alohedit in the interpretation of the "Son rewarded" need to study and graduate as the author had a care in clarifying the Quranic text without studying the conversations of care..4For the benefit and the benefit of the people of forensic science students.Research Methodology : 4Systematic research is as follows : .1According to the chatter in the interpretation of Ibn rewarded..2According to the imams directors to talk order of precedence in the deaths..3Talk to attribute its Mazan receipt in detail..4What Narrated by sheikhs or one of them. Limited to just mentioned, referring to the book and the door and talk and part number and the page. Men without attribution study or judgment. An agreement on the health of the nation contained therein..5study of men backing and translation them cite his name and surname and his fame and his scholarly wound and an amendment. It was correct in his novel was confined mostly to the book : Reagent and rounding. As well as the agreed documented. The narrators who disagreed imams in documenting and Tgeraham, it has proceeded to a multitude of sources. And who repeated his translation referred to as a pre - translated..6rule on the talk. Based on agreed rules of modern science. Citing as seen by the provisions of the imams on each interview..7explain the strange words contained in the Hadith and showed its meaning..8jokes reported some conversations that need to release..9According to the evidence and follow - ups to talk, if any.The research plan : 5The message consists of an introduction, three chapters and a conclusion and indexesAnd discussed in detail as follows : Introduction : It included the subject of the book and its importance, and the reasons for choosing the topic and research plan.Chapter One : Definition Son rewarded and the three InvestigationSection I : Definition Son rewarded and the five demands : First requirement : his name and lineage and his nickname and surname.The second requirement : Birth and upbringing.Third requirement : his scientific career.Fourth requirement : his works.Muttalib V : his death.The second topic : the definition and interpretation of his book in which four demandsThe first requirement : the reason for naming his book with : (easing Science download)The second requirement : the motive behind the formation son rewarded for this interpretationThird requirement : his method of interpretation.Fourth requirement : copies of the book and editions.6The third section and the two demands : First requirement : curriculum son rewarded in the inferred talkThe second requirement : definition of the Hadith : Approach son rewarded in the inferred talking.Chapter II : the study and the graduation of chatter coming from Saaffat to the Resurrection and the three topics : First topic : the study and graduation Alaha
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الحديث
السنة: 2017
الموضوع العام: العلوم الاسلامية
اسم المشرف: مجيد حميد ناصر المشهداني
اسم المؤلف: احمد هاشم علوان طبرة

اراء الامام ابن جزئ الغرناطي العقدية : دراسة مقارنة

الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: اصول الدين
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: سلام مجيد فاخر
اسم المؤلف: حيدر غالب محمد العنبكي

اختيارات سعيد حوى وترجيحاته في كتابه الاساس في التفسير Said Hawi's choices and his interpretations in his book The Basis of Interpretation

المستخلص: من خلال عنوان الرسالة يتضح ان مضمونها يدور حول الاقوال المختارة والراجحة لدى الشيخ سعيد حوى(1409ه)، التي تضمنها تفسيره( الاساس في التفسير)، والتي توصل اليها عن طريق استدلاله بمجموعة من ادلة الترجيح المعتمدة عند جميع المفسرين في اقوالهم الراجحة، وكذلك عن طريق مجموعة من الفاظ الترجيح الصريحة وغير الصريحة، التي اوردها في عبارات تفسيره.وكانت دراستي لهذه الاختيارات والترجيحات، من خلال جمعهوادراستهوامناقشتها مع اختيارات وترجيحات العلماء والمفسرين ممن سبقه وتبعه، وفق قوة الدليل الي يستدل به المفسرون، ووفق القواعد الترجيحية التي اعتمدوها في تفاسيرهم، فمرة اتوافق مع الشيخ سعيد حوى فيما يذهب اليه في ترجيحه، ومرة اشكل عليه في ترجيحه، وفق ما يظهر لي من ادلة، فخلف الدليل اجد ضالتي، فتراني دائما الهث وراء الدليل الصحيح، للوصول الى ارجح الاقوال واقربها الى الصواب، مع الاهتمام بابراز القواعد التفسيرية والوجوه الترجيحية قدر الامكان. بطريقة علمية تبين للقارئ مراد الله في الاية - بقدر الطاقة البشرية - ، وتوفر عليه عناء البحث في امهات كتب التفاسير ليصل اليه معنى الاية بصورة موجزة مقننة تقوم على الادلة الصحيحة باذن الله تعالى.وخطتي في البحث تشتمل على مقدمة، وثلاث فصول، وخاتمة. • المقدمة : وتضمنت : اهداف البحث، اهمية الموضوع واسباب اختياره، وصعوبات البحث، وحدود الدراسة، واهم الدراسات السابقة حول الموضوع، والمنهج المتبع في كتابة البحث.• الفصل الاول (التمهيدي) : وتضمن هذا الفصل : ترجمة موجزة عن حياة المفسر الشيخ (سعيد حوى).واسم تفسيره وسبب تاليفه ومكانته العلمية ومنهجه فيه.• الفصل الثاني : وتضمن هذا الفصل : التعريف بالاختيار والترجيح والفرق بينهموافائدتهموامحل وقوعهما. وصيغ واساليب الترجيح التي استعملها الشيخ في اختياراته وترجيحاته . وادلة ووجوه الترجيح التي اعتمدها الشيخ في ترجيحاته.• الفصل الثالث : وتضمن هذا الفصل : اختيارات وترجيحات الشيخ سعيد حوى في تفسيره.• الخاتمة : عرضت فيها بعض الاستنتاجات وبعض التوصيات.ان دراسة موضوع الترجيحات والاختيارات في التفسير، وبيان الصحيح من الاقوال وتحديد الراجح منها هو السبيل الامثل لتنقية كتب التفسير من رديء الاقاويل، وضعيف الروايات، وشواذ المسائل، وهذه التنقية من اهم ما ينبغي ان يعتني به اهل العلم المتخصصون؛ حتى يقوموا بواجب النصح للمسلمين، بتعليمهم معاني كلام الله تعالى على الوجه الاكمل.ولله الحمد والمنه، وصلى الله على رسولنا محمد وعلى اله وصحبه وسلم. | Praise be to Allah, Lord of the Worlds, and prayers and peace be upon the master of all creatures, our Prophet Muhammad and his family and companions and those who followed them with charity until the Day of Judgment. This is a summary of the scientific thesis, to obtain the degree of doctorate in the science of the Koran and entitled : (Said Hawi's choices and his interpretations in his book " The Basis of Interpretation"). Researcher name : Rasool Taha Khalaf Ayed Al Obeidi.Supervised by : Dr. mahmood abd al - lattef Through the title of the letter it is clear that the content revolves around the words chosen and most likely by Sheikh Said Hawi (1409 e), which included his interpretation (the basis of interpretation), which he obtained by using a set of weighting guides adopted by all the interpreters in their statements, A set of explicit and unambiguous words of weight, which he cited in the terms of his interpretation. The study of these choices and aspirations, through the collection and study and discussion with the choices and the calamities of scientists and interpreters of the previous and followed, according to the strength of evidence to be interpreted by the interpreters, and according to the rules adopted in their interpretations, once I agree with Sheikh Saeed Hawi in what goes to him in the swing, I have always sought to follow the correct evidence, to reach the most accurate and the closest to the right, with the interest to highlight the rules of interpretation and faces as much as possible. In a scientific way, the reader shows Murad Allah in the verse - as much as human energy - , and provides him with the trouble to search the mothers of the books of interpretations to reach the meaning of the verse in a concise manner based on the correct evidence, God willing. My research plan includes an introduction, three chapters, and a conclusion. Introduction : The objectives of the research, the importance of the subject and the reasons for selection, and difficulties of research, and limits of study, and the most important previous studies on the subject, and the methodology used in writing the research. The first chapter (introductory) : This chapter includes : a brief translation of the life of the interpreter Sheikh (Said Hawi). The name of its interpretation and the reason for its composition, scientific status and methodology. Chapter II : This chapter includes : the definition of selection and weight, the difference between them and their usefulness and place of occurrence. And the formulas and methods of weighting used by the Sheikh in his choices and his apprehensions. And the evidence and weighting factors adopted by the Sheikh in his weight. Chapter III : This chapter included : choices and assumptions Sheikh Saeed Hawi in his interpretation. Conclusion : Some conclusions and some recommendations were presented. The study of the subject of weights and choices in interpretation, and the correct statement of the words and the most correct of them is the best way to purify the books of interpretation of the poor rumors, and weak stories, and issues of questions, and this purification is the most important to be cared for by the specialists of the specialists; so they do the duty of advice to Muslims, By teaching them the meanings of the word of God in the fullest way. Praise be to God, and blessings and peace be upon our Messenger Muhammad and his family and companions
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: دكتوراه
الموضوع الدقيق: التفسير
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: محمود عبد اللطيف حمد الشمري
اسم المؤلف: رسول طه خلف عايد العبيدي

حكام فقهية مستنبطة من سورة التوبة : دراسة فقهية مقارنة The provisions of jurisprudence derived from Surah al tawba

المستخلص: Praise be to Allah the (SWT) we praise him and thank him, thank to Allah no one else, And Prayer and greetings be upon the messenger and the mercy to the worlds with guidance and the religion of truth Harbinger calling people and illuminating guides. Mohamed (peace be upon him) and his family who inspired by his guidance and walked on his approach to religion.But after : I will discuss in this thesis : the "jurisprudence derived from Surat Al tawba),Jurisprudence has received in this sura is particularly important that the science of Jurisprudence is one of the most importantlegitimate sciences and most proud,And that knowledge and understanding of science of Jurisprudence and legitimate provisions is a duty on the Muslim rational adult,There are many Quranic verses and Hadith Sharif urging Muslims to learn the rules of this holy science : Allah said by "meaning" (and it not for the believers to go forth {to battle} all at once . for there should separate from every division of them a group {remaining} to obtain understanding in the religion and warn their people when they return to them that they might be cautious.) And what is true for the Prophet (peace be upon him) : that he said((When Allah wishes good for someone, He bestows upon him the understanding of religion))(1) Al shafee said ( If someone realize Jurisprudence science in Quran as text and inference Allah helps him to say and work by what he learned : Won the virtue in his religion and worldly affair,And eliminated aboutsuspicions and illuminate necessitated in religion prayer position1 - Al - Bukhari and Muslim In conclusion, I made in my letter, I do not claim perfection because the message remains viable human job wrong or right so what was true then is from Allah and what was wrong, it was me and Satan and forgiveness of Allah it is forgiving, merciful.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الفقه المقارن
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: محمد محمود عبود العيساوي
اسم المؤلف: ايمان صباح نعمة

احكام الكلام في الفقه الاسـلامي العبادات والاحوال الشخصية انموذجا : دراسة فقهية مقارنة Provisions of speech in Islamic jurisprudence In acts of worship and personal status (A comparative study

الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الفقه المقارن
السنة: 2017
الموضوع العام: العلوم الاسلامية
اسم المشرف: سعدي خلف مطلب الجميلي
اسم المؤلف: نادية صباح حسين شلال

احكام الفقه السياسي في ضوء السيرة النبوية The provisions of political jurisprudence in the light of the Prophet's biography

الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: دكتوراه
الموضوع الدقيق: العلوم الاسلامية
السنة: 2017
الموضوع العام: العلوم الاسلامية
اسم المشرف: صلاح حميد عبد العيساوي
اسم المؤلف: مهند سعد قاسم سعيد العبيدي

احكام الجينوم البشري في الفقه الاسلامي

المستخلص: حاولت في رسالتي هذه التطرق الى مسائل الجينوم البشري، والالمام ببعض جوانبه العلمية، والفقهية، وانا بصدد استكمال متطلبات الحصول على درجة الماجستير.وكان من اهم اسباب اختيار الموضوع كمادة للبحث، والدراسة هي الضرورة الملحة للاسهام ببيان الاحكام، والاثار الشرعية لمجالات الجينوم البشري ،لاضفاء الحكم الشرعي على جوانب الموضوع كاساس للتعامل معه، وبيان حدود الجائز، وغير الجائز من مسائله ،والاثار المترتبة على احكامه.بالاضافة الى اظهار كمال الشريعة، واستيعابها لكل مستحدث، وملائمتها لكل جيل بما يغطي جميع ضرورات، وحاجات الناس، مع بيان ما يتصف به الفقه الاسلامي من القوة، والسعة، والقدرة على مسايرة المستجدات، والمتغيرات مهما كانت، ومواكبة التطور في نتائج البحوث النظرية، والعلمية في المجالات الوراثية، والاستفادة من البحوث العلمية، والشرعية السابقة المتعلقة بفقه النوازل في هذه المسالة.وفيما يتعلق بمنهج الدراسة ففي الجوانب الوراثية، والطبية برز المنهج الاستعراضي الوصفي، اما في الجانب الشرعي فغلب عليه الجانب الاستقرائي. وقد تم التركيز على الاساسيات المهمة للجينوم البشري، والتعريف بماهيته، والاحكام المتعلقة بدراسة هذا العلم المهم، واثره الاقتصادي في الفصل الاول، وبما ان مسائل الجينوم البشري هي وقائع مستحدثة تطرق ابوابا جديدة لم يسبق لاهل الفقه ان تعرضوا لها من قبل, وهذه المسائل تترتب عليها احكام شرعية عديدة, لهذا فان التجارب، والدراسات، والبحوث الجينومية يتوجب خضوعها للضوابط الشرعية ، الى جانب الضوابط العلمية التي يقررها المختصين بعلوم الوراثة، وهذا يحتم على علماء الامة الاسلامية لزوم اخذ المبادرة، او المساهمة ؛ لتصحيح وضع الابحاث الجينومية، وتاسيسهوافقا للاصول العقدية، والدينية، والاخلاقية، وتنقيحها مما علق بها من الشوائب، والمفاسد، وسائر الشبهات .والفصل الثاني تم تخصيصه لمجالات الجينوم البشري، واهم احكامها ؛ ولكون هذه النازلة متجددة الوقائع ؛ يتوجب النظر لها بحسب ميزان المصالح، والمفاسد، والنفع، والضرر.كما انه لا يصح اعطاء حكم عام للفحص الجينومي، بل يتوجب تقسيمه على مسائل، فالفحص الجينومي الاختياري بالنسبة للمقبلين على الزواج جائز شرعا ، فيما يكون الالزام القانوني بالفحص جائزا ، ولكن ليس على اطلاقه، ومع وجوب الحفاظ على سرية معلومات الفحوصات الجينومية ، لكن لها مدى تحدده اعتبارات عدة يتغير على اثرها الحكم الشرعي لافشاء سر الفحص الجينومي من الحرمة الى الوجوب، او الجواز.وتم التوصل الى مشروعية المسح الجينومي الوقائي بشرط ان تكون الوسائل المستعملة مباحة، وامنة لا تضر بالانسان، كما ظهر جواز الفحص الجينومي قبل غرس البويضات الملقحة مع مراعاة جميع الشروط الخاصة بالتلقيح الصناعي.اما في مجال للعلاج الجينومي فله اعتباران : احدهما عام من حيث المقصود منه، وهو اعتباره علاجا للامراض الوراثية، فيطبق عليه من حيث المبدا، الحكم الشرعي التكليفي للعلاج، والثاني : اعتبار الالية التي يتم اجراؤه فيها من حيث التدخل في اصلاح الخلايا المصابة، او ادخال شيء فيها لهذا الغرض، والظاهر اباحة هذا النوع من العلاج وفق الضوابط الشرعية.وفي الفصل الثالث تم دراسة التدخل الجينومي بانواعه التشخيصية، والعلاجية، والتحسينية؛ للتوصل لاحكامه، وتبين ان حكم التدخل التشخيصي الجينومي يختلف باختلاف وقت اجرائه، اما مسالة اثره في اجهاض الجنين المشوه فهي خلافية ،واختارت الباحثة مسلك التوقف عن ابداء راي فقهي فيها ،فيمراات ان اختيار جنس الجنين مباح بالجزء.والتدخل الجينومي في الخلايا البشرية الجسدية يحتمل فى النظر الشرعي القول بجوازه بقصد العلاج بشرط ارتقاء الصورة للاعتبار الشرعي عن طريق الموازنة بين المفاسد القائمة، او المتوهمة، والمصالح المرجوة من هذا التدخل، ذلك ان المعالجة الجينية للخلايا الجسدية ليس لها اي مردود على خط الخلايا التناسلية ،او اختلاط الانساب، لكن تعاطيها لغير مقاصد التداوي، كالمعالجات الجينية التجميلية لا ينهض بها للاعتبار الشرعي في ضوء ما تحتمله من مخاطر تفوق فوائدها.اما الخلايا البشرية التناسلية فهي توابع للابضاع والاصل فيها التحريم، واحتياط الشارع عند المساس بها، حتى ولو لاجل المقصد العلاجي ومن ثم فالاحكام فيها تناط بالخصوص، وذلك حال تضمن العلاج لحذف جين، اما حال اضافة جين بشري من شخص اخر فلواجه للنظر في اباحتها، ولو للمقاصد العلاجية، لتاثر النسل، والنسب بذلك. وتحسين النسل رغم انه مطلب شرعي الا ان اقترانه بوسائل التدخل الجينومي في الخلايا التناسلية البشرية مرفوض فى النظر الشرعي، ففي حال حذف الجينات تعوزه المقاصد المعتبرة شرعا لاباحة هذا التدخل، مع ما يكتنفه من مخاطر، وفي حال اضافة جينات لشخص اخر يصطدم بحرمة اختلاط الانساب المعلومة بالضرورة.وفي الفصل الرابع تم التوصل الى ان البصمة الجينية تعد ادق وسيلة معاصرة لاثبات هوية الشخص، وهي وسيلة لا تكاد تخطئ في التحقق من الوالدية البيولوجية، والتحقق من الشخصية، وهذه هي الميزة التي جعلتها ادق وسيلة لاثبات هوية الشخص ، وهو تم استثماره في مجال اثبات الجرائم، واثبات النسب على اختلاف احكامهما.ختاما هذه اهم النتائج التي خلصت اليها في هذه الدراسة، وهذا جهد المقل، يعتريه النقص، فما كان فيها من صواب فمن الله وما كان فيها من خطا فمني، واستغفر الله | Thank God the Lord of the Worlds and the prayers and peace on the seal of prophets and the messengers our Prophet Muhammad .In my letter I tried to address the issues of the human genome, familiarity with some of its scientific and jurisprudential aspects, and I am in the process of completing the requirements for a master's degree.The most important reason for selecting the topic as a subject for research and study is the urgent need to contribute to the statement of judgments and the legitimate effects of the human genome, to give to rule on the aspects of the topic as a basis for dealing with it, to indicate the limits of the permissible, the impermissible issues and the implications of its provisions.In addition to showing the perfection of the Shariah, its absorption for every novelty, and its suitability for each generation, covering all necessities and needs of the people, with an indication of the jurisprudence of the Islamic power, capacity, the ability to keep abreast of developments, the variables no matter what, and keep up with the evolution in the results of theoretical and scientific research in Genetic areas, the use of scientific research, and the previous jurisprudence on the doctrine of the issue in this matter.The approach to study in the genetic and medical aspects of the descriptive review approach, the legitimate aspect was dominated by the inductive side.The researcher in chapter I tried to focus on the important basics of human genome, the definition of what it is, and the provisions for studying this science important, and its economic impact, and since human genome issues are novel facts that have touched upon new doors that have never been before the people of Fiqh. And this The issues have many legal provisions, Therefore, experiments, studies and genomic research must be subject to the legal controls, along with the scientific disciplines that determined by the genetics specialists, which makes it imperative for the scholars of the Islamic Ummah to take the initiative, or to contribute; To correct the research situation Genomic, established according to the origins of the nodal, religious, and moral, and refined from the suspended impurities, feats, and other suspicions.Chapter II has been devoted to the areas of the human genome and its most important provisions; This is a regenerate of fact; it has to be considered according to the balance of interests, the feats, the benefit and the damage.It's not right to give a general judgement to the genomic examination; it has to be divided into matters. The optional genomic examination for the future of the marriage is permissible for lack of proof, while the legal obligation to examine is permissible, but not on its release, and the confidentiality of examination information must be preserved The genomic, however, has a range determined by several considerations, the effect of which is the legal provision to disclose the secret of the genomic examination from inviolability to necessity or permissibility.The legality of the preventive genomic survey was reached provided that the means used are permissible and safe and not detrimental to the human being, the genomic examination also appeared before the implantation of fertilized eggs, taking into account all conditions for artificial insemination.In the area of genomic treatment there are two considerations : one general in terms of what is meant to be a treatment of hereditary diseases, which in principle applies the legal provision of therapeutic treatment and the other : consider the mechanism in which to intervene in repairing infected cells, or entering something in them For this purpose, it is apparent that this type of treatment is legalized in accordance with the legal controls.In chapter III, the genomic, therapeutic and diagnostic interferences were examined to reach its provisions, and it was found that the provision the diagnostic intervention of genomic varies at the time of the procedure, and the question of its effect on aborting a deformed foetus is controversial, and the researcher has chosen a course of action to stop expressing a doctrinal opinion In the opinion that the choice of the sex of the foetus is permissible in the part.Genomic interference in the physical human cells is likely to be legitimately considered to be permissible for treatment, provided that the image is considered legitimate through balancing of existing or delusional feats, and the desired interests of this intervention, that the genetic treatment of the cells has no results On the line of the reproductive cells, or the mixing of the genealogy, but its use for non-medication purposes, such as cosmetic genetic treatments, is not given due consideration in the light of the risks that outweigh its benefits.Reproductive human cells are the descendants of the parent and the origin of the prohibition, and the street precaution when they are compromised, even for the therapeutic purpose and in particular, the provisions are vested in them, in the event that the treatment to delete Jane is guaranteed, either the addition of a human gene from another person is not considered in pushed, even for purposes Therapeutic, for the influence of offspring, and proportions so.Although it is a legitimate requirement, the improvement of the offspring, coupled with the means of genomic intervention in the human reproductive cells, is rejected in the legal consideration, in the event of the deletion genes that do not have the intent to legalize such interference, with the risks involved, and in the event of the addition of genes to another person who faces the inviolability of genealogy Information necessarily.In chapter IV, it was concluded that the genetic footprint was the most accurate contemporary means of proving the identity of a person, which was not a very wrong way of verifying biological parenthood, the verification of the personality, and this is the advantage that made it the most accurate means of proving the identity of the person, which has been invested in the field of proving crimes, and proving The percentages vary from their provisions.In conclusion, this is the most important outcome of this study, and the right from God and what was wrong it is from me, and Astaghfir Allah.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الفقه المقارن
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: اركان يوسف حالوب
اسم المؤلف: حنان شاكر حمود

احاديث الجنة واسباب دخولها في الكتب التسعة : دراسة موضوعية

المستخلص: Chosen praise be to God good of the scientists and the prayer and his the peace on lover Mohammed and on his generous family of house aal'aThaar and his friends the welfares aal'abraar and their blessing on panting and their belief walked and peace of deliveries many throughout the night and the day After : To Allah Heaven introduced. trGybaaAA in her. Between for us divided from ne'ymhaa and hidden meant divided ، increase in the awakening of a desire and the suspense. Therefore so indeed Naim Heaven whatever descriptive ، does not know him e'qwl for that in her blessing benevolent money notifies on mind followed introduces him sharp in situation. Indeed her immortality and stay revolved. In her courage followed misery ، sadnesses followed crying followed. Her delights do not elapse followed ends msraathaa. All what in her the brain amazes and the thought bewitches. The reason closes. The core throw down 0 She is paradise Taabt wTaab ne'ymhaa ، fne'ymhaa remaining and not in transient ، she maneuvered ytl'al'a ، wryHaant thtz.wqSr praising and days of steady. .wfaakht ripe. Wife of Hasna' is beautiful. Many absolutions in place never ، in Hbrt wnDrt ، in high role sound brilliant ttraa'Y for her family just as ytraa'Y the planet aaldry sunken in the horizon. Losing bring good news Allah his glory and his worshipers rose his the rescuers in worship and truthful in produce aalne'ym which exquisite in character her lyjaazyhm on good their statements and their acts ، and making of Allah rose Heaven the place who finds in him the insured slave all what desires him himself from good and appetites left about her in live his the life is approach from Allah rose and his greed in reward and his fears from punishment ، and the paradise creature from creatures Allah as the land and the sky and changes her ، and the generous Quran in several names and her arrived in blessing paradise of the paradise and house of the eternity and the established faithful place and paradises aale'dn and house of the peace 0.Mentioned in the Quran generous and the year is prophetic honorable descriptive and elongated explanation about Heaven and created her and what contains him from rewarding and blessings and prizes for the insured slave ، so Heaven from where the area notifies what expanded him aalsmwaat and the land ، followed the skies intend in the sky which sees her yet the skies the seventh is gathered together ، adequate her from the jinns and the trees and river and the valleys what mind does not notify on bring good news ، so her rivers differs about days of the land ، so instead of from the water occurs in her the wine hit wine of Heaven wine of the land be distinguished about that he bland - tasting followed the brain goes ، and river tjf from the yogurt and the honey ، just as corrodes me on analgesic for insured mshyydt from the pearl and the gold and the silver ، does not cut off in her the food followed the beverage and as to what on you to does him he to is complete us what desires to lac comes on Dishes from gold ، just as corrodes me Heaven on beautiful what the shaahd eye from the trees the permanent vegetable and the shadow 0differs printing inhabitants of Heaven about what was on him in Al - Hayat the life ، fttThr their hearts from feelings of the life from spite and envious and hatred and hatred llGyr ، so in Heaven all them brothers one does not look from them to the other to and lovable his ، followed madder to the good talk the scent come out from their ، and insured in Heaven is the comfortable mind from the worries which shoulders in Al - Hayat become heavy his the life so request of the blessing does not be occupied in or cleaning alleviating and changes her from worries of Al - Hayat the life ، yet lives the comfortable mind reassuring without to their mind feels or aalrhq or the sadness or the despair ، and this comfort extends forever so blessing enters Heaven does not come out from her 'abdaaAAytwHHd ages of the people in Heaven ، so all family Heaven in beginning forms the thirty ، clothes what clothes want from mxaaTt from the natural silk and sweetened baalaastbrq and embellisher in the sarcenet ، and lives in her safely with their husbands ، and the eye intends in their husbands the marked contrast between white and black the tough beauty and composed him her character Allah to reward loves on what welfare in Al - Hayat industrialized from the life ، and straightens on served them lads of honored does what requests from them without argument or discussion
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الحديث
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: رائد محمد عبد العبيدي
اسم المؤلف: زينب ابراهيم عبد جلوب

احاديث التقرير التصريحي في الكتب الستة : دراسة موضوعية

الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: دكتوراه
الموضوع الدقيق: اصول الدين
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: انس محمود خلف العيساوي
اسم المؤلف: صباح لطيف عبد الله الدليمي

احاديث ادارة الاولويات في الصحيحين : دراسة تحليلية

المستخلص: Praise be to Allah, the Lord of the Worlds, and prayers upon our master Muhammad and his family and companions. Islam has come to regulate the life of the Islamic community through the gradualization of legislation and arranging the necessities of life according to its priorities and importance to the Muslim individual, the family and the society. I wanted to extricate myself from the flood of the Holy Quran and behind the purified Sunnah. I have derived research material from them and after consultation with some of my professors. In a topic on our contemporary reality, and what should be written about, an optional choice has been made (Prophetic says in Managing the Priorities in Al - Sahehain - An Analytical Study), one of the topics that is closely related to our human life In this study, I dealt with the Department of the Prophets in the Prophetic Sunnah which I presented today, in which I spoke about a subject that I considered extremely important because it deals with issues from the point of view of legitimacy in assessing things, ideas and actions, and presenting each other, and whoever submits and which ones should be delayed. The first, and any other order in the hierarchy of divine orders and directions of the Prophet. It was based on the six books in the graduation of the alhadeeth for a large number of alhadeeth. I studied it in an analytical study. My attempt in this study was to highlight a number of alhadeeth which mentioned the priorities and which the year came to indicate. The role in the presentation of thought and the payment of the curriculum, and the consolidation of this type of the year, so as to guide the workers who graduated to distinguish what the Sharia and what is delayed, and stressed by the mother and pleased, and the greatness of religion and what matters, based on the words of scientists and scholars Of the people of Hadith and jurisprudence and adopted in this on the Original output to access the feed - as far as possible - to find out the right side of it. Through this study we can identify the priorities and the importance and the need of our nation to prioritize life after the people are unaware of them, especially on this day when the circulation between people and in reality .. This study is the opening of the door and paving the way .. Allah has made it more powerful and influential, and each hardworking share. The subject of the thesis dictated its division into an introduction, three chapters and a conclusion.Chapter I : Definition of the administration, priorities, elements and benefits.It has been divided into two sections : The first topic : Definition of management and priority language and terminology and statement of benefits.The second topic : priorities according to importance.The second chapter : priorities in worship.It includes three aspects : The first topic : priorities in the prayer of the congregation, the virtue of Mecca, and the pilgrimage to mosques, and Zakat al - Fitr.The second topic : Priorities in the religion of the deceased, good companionship, offering dinner on prayer, and best deeds to God.The third topic : priorities in the delay in delaying prayer when the severity of the heat, the Muslim from the Muslim ladder of his tongue and hand, the construction of the submission of the certificate in Muslim Islam on the otherChapter Three : Priorities in Transactions.It includes two sections : The first topic : Priorities in the will, charity, and the share of kinship, charity and wealth.The second topic : the priorities in the snapshot, the sale of palm trees, and the rich.The third topic : priorities in the initiative to work, business early, and seize time, and see the crescent.The fourth topic : priorities in the question of the slave on the Day of Resurrection, health and emptiness, and the right of the body to fast.Then the conclusion and a list of sources and references.The thesis reached the most important results : 1 - dealt with the concept of priorities because of its special importance to the large circulation in our reality and concluded that he knows that the priorities of the rule based on the understanding of the most appropriate and better than the work and knowledge of the virtuous business and its preferences, and the most likely and Almargoha based on science linked, and in fact to require, For the purpose of achieving the most important interests, the slightest damage, and knowledge of the consequences of the application of such works.2 - I found that the priorities must be taken into account (terminology) by reading the texts of the Koran, the Sunnah and the words of some scholars and analysis of these texts and sayings.3. It was highlighted through the study that the principle of prioritization is fixed and specific in Islamic law, and that the determinants help to adjust the methodology of priorities and demonstrate how they are observed, and that evidence of prioritization is many.4 - If the food comes at the time of prayer, scholars have different opinions on that, if at the time the capacity of the foot of the food on prayer, so as not to concern the heart and go reverence, and some of them proceeded to eat and then pray is based on prayer and not eating, Who commanded eating before the prayer, from whom he did not start, so that he would not be preoccupied with him.5 - good deeds are all good and beloved to Allah Almighty, but some of the best works and more than others and more fixed and higher degree, including prayer at the time. Is the priority and then the parents and Jihad in the way of Allah.6 - It is permissible to go back to the back in the warm country in the heat of the heat, so the prayer is delayed until the end of its time.7 - The Prophet (peace and blessings of Allah be upon him) singled out the tongue and the hand among all the other narrators and the multitude of their mistakes and harms. Most of the evils are issued by them, so the Prophet (peace and blessings of Allah be upon him) singled out them in this hadeeth and gave them precedence over others.8 - The sale of palm trees after tipping priority to be the fruit of the seller, even if the fruit of the fruit.9 - priority in the fulfillment of debt and non - procrastination when a person is rich and able to repay it does not apply to the poor.10 - The priority of the initiative of good work before the impediments to prevent it and the first poverty to Yenisk or richness of the disease and the corrupt or pyramid or death.11 - The early of each of the priorities of the Muslim, whether in the request for livelihood or jihad or trade does not mean not to early lack of blessing, but the intended du'aa 'who begins his knowledge early, the time of his activity pray to receive blessings.12 - reminds us of the Prophet (peace be upon him) to seize five before five and introduced it according to priority importance, including young people offset by the pyramid, health and sincerity, and the richness of poverty and vacancy, life and death. The Muslim must take advantage of this before it is too late and he can not do it. Among his good deeds is the pyramid, misery, poverty, occupation and death.13 - The origin at the beginning of the month of Ramadan is the vision of the crescent unless it is clouded, and it is not permissible for a man to fast before entering Ramadaan. And that the wisdom of this is to distinguish the obligatory acts of worship from the naflha and that the ruling on fasting is dependent on seeing the crescent.14 - The priority of the Muslim is to maintain time, which is the most expensive possession of man and must preserve it because the first thing to come to him on the Day of Resurrection and the age that he spent in his life, and youth and money whether used in obedience to Allah or not. The Prophet (peace and blessings of Allah be upon him) arranged it according to its importance. The first is the exploitation of blessings before their demise, and in this he urged the exploitation of human health before his illness and emptiness before his occupation.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الحديث
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: مصطفى فرحان عوض
اسم المؤلف: نور الهدى عثمان علي حسين المفرجي

اثر مقاصد الشريعة في الهندسة المالية الاسلامية The impact of the purposes of the legitimacy in the Islamic financial engineering.

المستخلص: In the name of god , thank god , and peace on prophet of Allah and on his companions . I'll start my words by who is better .. glory to be Allah , we have no knowledge except what you have taught us , you Alim Hakim . But after : The purpose of legitimacy is the supreme scientific reference , realism translation process was expressing of the human interests of all necessary, needful and improvement which must be nurtured and maintained and harness all possible means to serve and take care of it , all payment would create something of them , the five purposes are the greatest aims of the street and the finest human interests which underlying architecture and by all of them the human civilization was continue . The intent of this whole is honoring people and his service to do what was create of , it is to be a slave to god optional by them choice mandatory ( ) , and with the development of interest in Islamic economy and the expansion of the Islamic banking industry . it began the need to have an Islamic decades formats .. it was not there before like (the rent ending to ownership and the parallel forward buying , Islamic instruments , and ETC ).These are all financial innovations . Financial Engineering aimed to find products , Financial instruments to achieve standard macro and micro efficiency both. By the way achieving efficiency products for legitimacy is the basis of being Islamic , prevent usury, ambiguity , injustice , consuming people's wealth unlawfully , and ETC . But economic efficiency achievement in it their ability to the growing and renewable the economic needs . Also Islamic financial institution always need to keep a variety of tools and financial products which enable them to profitably manage their money As well As providing appropriate flexibility in response to change in the economic environment and also that reliance on a single product is not sufficient to cope with the expectation of customers .Thus highlighting the importance of this study In an attempt to shed light on the impact of the legitimate purpose in the Islamic financial engineering industry that is suitable for finding innovative solutions and new financial instruments tool. Even savings of the nation employs a way that achieves the economic development .. taking into account that the approval of Islamic legitimacy from and content The problem of this study : It is stand on what's legal opinion about financial solutions and innovative financial instruments by processing Multi - risks which surrounding Islamic banking to save investor's money . This risks is credit risks , market risks , money risks , and operational risks which faced by the investment portfoin under the Islamic banking system , and research on the progress of the Islamic financial Engineering for tools and methods are flexible and realistic of what it need these issues from understand the reality and the requirements of the application to provide an opportunity for investor through it reduce losses and risks , through diversifying its investment , and the choice of financial instrument that improve money management and investing all of this with legal (prevent usury , deception , injustice , and the fraud) which helps to the distribution of financial and economic resource more evenly and efficiently . The difficulties that I faced in the study : That lack of economic studies and research centers which concerned with research of Islamic financial market in Iraq. in addition to all that most of studies in the international financial market is usually in English . As well as the international Islamic financial market's website is in English too . So I faced the difficulty of lack resource and research in Arabic , as well as the difficult security condition that we face in the country .the study's methodology : I have used abstract useful analytical inductive and deductive to visualize an application for all formats and Islamic investment tools and discovery latest methods and techniques to expand the circle of funding , discovery a new banking concept formats and the development of existing formulas to keep pace with development it's in banking to receive more money which increased revenues over time and maximize profitability by controlling operating expenses and reduced .As for the plan of structural I was prepared for this study it's as follows included on the foreword and three chapters .Chapter one . identify concept and terms constituent of this study and includes two section - first section , the definition of the purposes of Islamic legitimacy and it's characteristics and division - second section, which includes the definition of Islamic financial engineering and its inception , importance ,its principles , founded , characteristics of their products , and their curricula .Chapter Two . the diversity of Islamic financial engineering products its included two section - first section , products based on real assets ( sale and rent ) - second section , products based on profit partnership ( decades partnership).The third and last chapter . the impact of the purpose of the legitimacy in the Islamic financial engineering products , it's included three sections.First section , the impact of the purposes of the statements of legitimacy in profit to buy something , parallel forward buying , parallel custom order , the rent ending to ownership and including hedge means. - second section , the impact of the purposes of the legitimacy to participate ending with ownership , common speculative, and the ways in which hedge. - the third section , the impact of the purposes of the legitimacy in applied models for Islamic financial engineering products. And the conclusion was included on the importance results that would take into account to the need of Islamic banking
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: الاقتصاد الاسلامي
السنة: 2016
الموضوع العام: الادارة والاقتصاد
اسم المشرف: كاظم خليفة حمادي ابراهيم كوان علي
اسم المؤلف: سوسن عبد الله عزيز

اثر الامن الفكري الاسلامي في حماية المجتمع من الفتن : دراسة فكرية The Impact of Islamic Intellectual Security In the protection of society from the strife Intellectual study Athesis introdnced

الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: العربية
الدرجة: ماجستير
الموضوع الدقيق: اصول الدين
السنة: 2018
الموضوع العام: العلوم الاسلامية
اسم المشرف: حسين عليوي حسين الطائي
اسم المؤلف: واثق مانع محمد الجميلي

دراسة الدهون الاسفنجية النشطة بايولوجيا والانزيمات الاستقلابية في كل من تضخم البروستات الحميد وسرطان البروستات الخبيث Bioactive Sphingolipids and metabolizing enzymes in patients with benign prostate hyperplasia and malignant prostate cancer

المستخلص: Bioactive Sphingolipids an important molecules of structural and signaling lipids. In this study was highlight on new biomarkers uses to investigate prostate cancer by using new method HPLC fluorescence detector to measure concentration and activity enzymes sphingosine - 1 - phosphate lyase enzyme (SPL) and Acid Ceramidase enzyme (AC) by used new material (BODIPY) aromatic structural is binding with enzymes and give fluorophore product sensitive by HPLC fluorescence detector in patients have BPH and PC in serum and tissue and comparing with healthy men as (control). Eliza method was used to measured sphingosine - 1 - phosphate and Ceramide in patients (BPH and PC) in serum and tissue with controls in serum. Sphingolipids metabolites pathological processes, are established regulators of myriad cellular and sphingolipids research is intricate due to the role of these molecules in vastly different biologics, interconnected metabolic pathways and structural properties. Ceramide and sphingosine - 1 - phosphate (S1P), SGPL and AC have been defined as reciprocal regulators of cellular fate, and not surprisingly have been targeted for their role in cancer and their therapeutic potential, sphingolipid metabolic enzymes and lipids are metabolically interconnected and highlight recent findings to support the reciprocal role of Ceramide and S1P in cellular processes and in cancer. Studies show increase levels markers in serum and tissue in BPH and PC with healthy men and different Km and V max in AC and SPL between healthy, BPH and PC patients also this reaction was noncompetitive inhibition with enzyme because V max was change and Km was not change in all cases these results were accepted with studies in America and Spain (Liu, Y.Y.; Patwardhan, G.A.;et al. 2011).IXAim of study1 - 1 - The main aim of this study is found a new sensitive and specific bio markers for diagnosis prostatic cancer And other goals of conducting this study are : 2 - To measure activity of Acid ceramidase and Sphingosine - 1 - Phospate Lyase in sera and prostate tissue of patients with benign prostatic hyperplasia and prostate cancer and compare these activities of enzymes with normal controls.3 - To determine the concentration of bioactive Sphingolipids Ceramide and Sphingosine - 1 - phosphate in tissues and sera of the patients and control.4 - To correlate the level of bioactive lipids with serum PSA concentration to detect their use as additional biomarker for diagnosis and follow up of patient with prostate cancer.Methods : A case - control study design was employed in this study. On a total of 30 patients with confirmed PC, 30 patients with BPH and age matched 30 healthy men. Prostate tissue samples were obtained for patients were serum and urine samples were collected for patients and controls. Enzyme linked immune assay (Elisa) was used to measure S1P and Ceramide concentration in serum and tissue, while HPLC fluorescence detector was used to estimate activities of SPL and AC and measured Km and V max. Urine and serum samples were undergone biochemistry analysis. HbA1c was used to measure cumulative sugar for three groups. Protein in tissue was measure by brad ford method to PC and BPH patients.Results : The results showed that increase levels of Sphingosine 1 phosphate lyase and Acid ceramidase in serum and tissue in BPH and Malignant cancer in men these levels were different result in patient wereXtaken drugs or not and patients were taken chemotherapy or not and activity, Km and Vmax of enzyme SPL and AC were different in BPH and PC that men is inhibition enzymes was noncompetitive it had same Km but different data of control, BPH and PC men in tissue and serum.The concentration of S1P and Ceramide were different levels with control, and high levels in patients without any drugs or chemotherapy while levels of these markers still low with patients were taken drugs or chemotherapy and level of protein in tissue were raised. Results of biochemistry analysis still normal because we take patients without any D.M., renal failure, and hypertension.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: الكيمياء الحياتية الطبية
السنة: 2017
الموضوع العام: الطب
اسم المشرف: رائد جاسم محمد التميمي اسامة سليمان قدوري الناصري
اسم المؤلف: رغدة عبد المنعم رزوقي

تقييم الانزيمات المعدنية المحللة للبروتين - 9 MMP - 9 والانترلوكين - 18 (IL - 18) في دم الحبل السري والنسج البيني في الولادات القيصرية والمهبلية الطبيعية Matrix Metalloproteinase - 9 and IL - 18 Level in Cord Blood and Tissue Matrix in Caesarean and Normal Vaginal Delivery

المستخلص: ماتركس ميتالوبروتياز Matrix metalloproteinases اختصارا (MMPs) وهي انزيمات تعتمد على الزنك وتحتوي على اندوبيبتيداز endopeptidases . هذه الانزيمات لها القدرة على احداث التحلل في جميع انواع البروتينات للمصفوفة خارج الخلية، ولكن ايضا يمكن معالجة عدد من الجزيئات النشطة بيولوجيا. ومن المعروفة انها تقوم بالمشاركة في انشقاق والانقسام لمستقبلات سطح الخلية، واطلاق المعقدات المسؤولة عن موت الخلية (مثل معقد FAS)، وعدم تفعيل السيتوكينات cytokines. وايضا خلال فترة الحمل تحدث تغيرات فسيولوجية خاصة مثل نضج عنق الرحم، وتمزق الاغشية الجنينية، وانفصال المشيمة والذي تتطلب اعادة تشكيل المصفوفة خارج الخلية (ECM) . السيتوكين مثل الانترلوكين (IL - 18)يلعب دورا حاسما في دفاع المضيف، وانها قد تكون جزء في توفير حاجز لعنق الرحم/ ساقطي ضد الغزو الميكروبي من السائل الذي يحيط بالجنين وقد يكون بمثابة علامة لعنق الرحم للعدوى داخل الامنيوتك Amniotic. الاجهاد التاكسدي، وهي حاله تتميز بعدم التوازن بين الجزيئات المؤكسدة، بما في ذلك الانواع الاكسجين التفاعلية (ROS)، وبين دفاع المضادات للاكسدة Antioxidant . هذه ROS قد يسبب اصابات الانسجة مما يؤدي الى تلف البروتينات الخلوية داخل الخلايا ، والحمض النووي DNA التي تورطت في مضاعفات الحمل في بوقت مبكر اثناء المخاض، ويمكن ان يؤثر على طريقة الولادة . استجابة الجسم المناعية تتضمن المضادات للاكسدة الانزيمية وغير الانزيمية التي تقلل من تاثير هذه الجذور الحرة. تهدف هذه الدراسة الى تقييم العلاقة بين مستويات انزيم ماتركس ميتالوبروتياز - 9 (MMP - 9 )ووضعية الحمل. الطرق : في هذه الدراسة تم تعيين ستة واربعين النساء الحوامل (31 حاملا خضعن للولادة الطبيعية، 33 حاملا خضعن للولادة القيصرية. . تم جمع نموذج الدراسة من صالات النسائية والتوليد في مدينة الامامين الكاظمين الطبية خلال فترة من حزيران من 2015 الى تموز من 2016.واخذت موافقة النساء الحوامل قبل الدخول لصالة العمليات, وتم اخذ عينات من الدم وقطعة من النسيج جمعت خلال خمس دقائق من الحبل السري. تم جمع عينات الانسجة الحبل السري ايضا اثناء الولادة. واستخدمت عينات دم وانسجة لقياس الفلزي المصفوفة (MMP - 9)، وانترلوكين 18 (IL - 18)، وايضا تم استخدام نماذج الدم لقياس معدل جهد التاكسد في مصل الدم والمضادات للاكسدة (SOD) والعناصر النزرة. النتائج : اظهرت النتائج ان تدهور في المستويات الحيوية ل( MMP - 9و IL - 18) في الدم النساء اللواتي خضعن الولادة الطبيعية. وكانت عالية في النساء اللواتي خضعن للعملية القيصرية وبالاضافة الى ذلك، فان مستويات الانزيمات المضادة للاكسدة الاقل بين النساء اللواتي خضعن للولادة الطبيعية واعلى بين النساء اللواتي خضعن للعمليات القيصرية. وذكرت في الدراسة ايضا انخفاض كبير في مستوى العناصر النزرة المؤشرات الحيوية (الزنك والنحاس والمغنيسيوم) في الدم النساء اللواتي خضعن للعملية القيصرية مقارنة مع مجموعة النساء اللواتي خضعن الولادة الطبيعية. الفحص النسيجي للنسيج الحبل السري من النساء الحوامل كشفه عن نتائج مطابقة لنتائج فحوصات الدم حيث بينت عن ارتفاع معنوي في تركيز انزيم MMP - 9 والانترلوكين IL - 18 في النساء اللواتي خضعن للعملية القيصرية مقارنة مع مجموعة النساء اللواتي خضعن الولادة الطبيعية.الاستنتاجات : ارتبط الولادة الطبيعية مع زيادة الاكسدة وانخفاض في النشاط المضادة للاكسدة وفي المقابل انخفاض الاجهاد التاكسدي وزيادة في النشاط الانزيمي المضادة للاكسدة (SOD) في الولادات القيصرية ،. واضاف لذلك ارتبط الولادة الطبيعية بانخفاض معنوي في مستويات انزيم MMP - 9 والسايتوكينات IL - 18 مقارنة مع مجموعة النساء اللواتي خضعن الولادة الطبيعية. ومن ناحه اخرى اظهر الفحص النسيجي هنالك تركيزات عالية MMP - 9 وIL - 18 في الانسجة الحبل السري للمراة التي تخضع للعملية القيصرية بالمقارنة مع النساء اللواتي الولادة الطبيعية. | Matrix metalloproteinases (MMPs) are calcium - dependent zinc - containing endopeptidases. These enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and cytokine inactivation. During pregnancy, specific physiological changes such as cervical ripening, rupture of the fetal membranes, and placental detachment require the remodeling of the extracellular matrix (ECM). Cytokine like Interleukin - 18(IL - 18) play a critical role in host defense, and it may participate in providing a cervical/decidual barrier against microbial invasion of the amniotic fluid and might serve as a cervical marker for intra - amniotic infection. Oxidative Stress, a state characterized by an imbalance between pro - oxidant molecules, including reactive oxygen species (ROS), with antioxidant defense. These ROS may cause tissue injury resulting in cytotoxic damage to cellular proteins, and DNA which has been implicated in early pregnancy complications and during ,labor and may effect on mode of labor. Body defense response involves enzymatic and non - enzymatic antioxidant buffering pathways which reduce the effect of these free radicals. This study aimed to assess the relationship between matrix metalloproteinase enzyme levels and delivery mode and also an attempt to assess the impact of oxidative stress on maternal antioxidant defense during labour and correlate it with mode of parturition. Methods : A case - control study design was employed in this study. Sixty four pregnant women were recruited 31 term pregnant women with normal vaginal delivery and 33 term pregnant women underwent cesarean section delivery. At the time of their admission to operation theatre, blood samples were taken and a piece of tissue was collected from umbilical cord after delivery . Blood and tissue samples were used to measure matrix metalloproteinase (MMP - 9), Interleukin - 18 (IL - 18), Superoxide Dismutase (SOD) activity and trace elements levels was determined in the umbilical cord blood only. Placental tissue was prepared and stained for histological assessment. Anti - MMP - 9 and Anti - IL - 18 monoclonal antibody laboratory kits were employed to demonstrate degradation and cytokine levels in umbilical cord tissue. Results : results showed that both blood MMP - 9 and IL - 18 levels were significantly higher in term women who underwent cesarean section compared with those women who underwent normal vaginal delivery. In addition, the enzymatic anti - oxidant SOD was significantly lowest among term women who underwent normal vaginal delivery when compared term women who underwent cesarean section. The present study also reported a significant decreases in level of trace elements (Zn, Cu and Mg) in blood of term women who underwent NVD compared those a with C/S labor (P<0.01). The histological examination of umbilical cord tissue revealed that term women underwent normal vaginal delivery group had the lowest reactivity with both anti - MMP - 9 and anti - IL - 18 monoclonal antibody in comparison to term women underwent cesarean section group. From the study it was concluded that term pregnancy women underwent normal vaginal delivery was associated with increased oxidative stress and decreased anti - oxidant activity. In contrast, term pregnancy underwent cesarean section was associated with low oxidative stress status and high enzymatic anti - oxidant activity (SOD). In other hand, pregnancy underwent with cesarean section was significantly associated with high levels of serum MMP - 9 and IL - 18 and high level of enzymatic anti - oxidant activity (SOD). While the Histological examination showed high MMP - 9 and IL - 18 concentrations in the umbilical cord tissue of term women underwent cesarean section in comparison to term women underwent normal vaginal delivery
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
السنة: 2016
الموضوع العام: الطب
اسم المشرف: ريا سليمان صلاح الدين بابان مي فاضل ماجد الحبيب
اسم المؤلف: خوله عبد الحمزة شمران مشجل

دراسة كيميائية حياتية لارتباط المستضد بضاده الحيوي في مرضى داء CA19 - الكاربوهيدراتي 9 السكري من النوع الثاني باستخدام مقايسة الممتز المناعي المرتبط بالانزيم مع بعض التحويرات Biochemical Studies of the Binding of CA 19 - 9 to its Antibody in Patients with type 2 Diabetes Mellitus using Enzyme - Linked Immunosorbent Assay with some Modifications

المستخلص: Carbohydrate Antigen CA19 - 9 has been widely utilized for diagnosis of different kinds of cancer such as pancreatic cancer, cancer of upper gastrointestinal tract. It may also be used as an indicator of pancreatic tissue damage that may be caused by diabetes.The method of enzyme linked immunosorbent assay (ELISA) for measurement CA19 - 9 in sera of patients with type 2 diabetes mellitus was developed using external CA19 - 9 antibody (competitive sandwich ELISA technique) and found to be suitable for the determination of a dissociation constant (Kd) of the binding of CA19 - 9 to its antibody in type 2 diabetic patients using scatchard plot. Objectives : - This study was performed to assess CA19 - 9 levels in sera of patients with type 2 diabetes mellitus with non - cancerous tissue by enzyme - linked immunosorbent assays (ELISA) and define the normal range (cutoff value) for the same marker in this patients also investigated the possible relationships of CA19 - 9 with fasting plasma glucose and HbA1c.This study present a new method for determination the dissociation constant (Kd) of the binding of CA19 - 9 to its antibody in type 2 diabetic patients using scatchard plot through development of ELISA (competitive sandwich ELISA technique).Different factors affecting this binding were extensively studied such as divalent cations, different halides, and Polyethylene (PEG - 6000).
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: الكيمياء الحياتية الطبية
السنة: 2016
الموضوع العام: الطب
اسم المشرف: حسن حسين طه السعيد محمود شاكر خضير
اسم المؤلف: رسل رياض عباس

قيمة التتبع النقطي المقطع بالموجات فوق الصوتية لعضلة القلب للكشف عن مرض الشرايين التاجية مقابل تصوير الاوعية التاجية Detection Of Coronary Artery Disease Using 2D - Regional (Segmental) Longitudinal strain (RLS) Comparing with Coronary Angiography in Patient with Acute Coronary Syndrome

المستخلص: Background : Speckle - tracking echocardiography is a new noninvasive ultrasound imaging technique that allows for evaluation of global and regional myocardial function.Aim of the Study : to evaluate the accuracy of regional(segmental) longitudinal strain by 2D - STE for pick up culprit vessels in ACS by detecting ischemic segments of the corresponding territories and its severity compared with coronary angiography as a gold standard, in patients with acute coronary syndrome .Patients and Methods : A cross sectional study was held in Baghdad teaching hospital from March 2017 to March 2018, consisted of patients with acute coronary syndrome(ACS) underwent 2D - STE for left ventricular regional longitudinal strain(RLS) immediately before invasive coronary angiography .Results : Fifty patients who fulfilled the inclusive criteria were enrolled in this study. The mean age 57.2 (± 7.9) years; and male : female ratio 1.9 : 1. Regional Longitudinal strain - speckle tracking showed 38 patients had CAD and 12 patients had no CAD, Versus coronary angiography which showed 29 patients had CAD while 21 patient had no CAD or non significant lesions.The validity of RLS according to coronary angiography showed sensitivity 100%, specificity 57.1% ,PPV 76.3%,NPV 100%, and accuracy 82%.Conclusion : The current study revealed that (RLS) Speckletracking echocardiography technique has high sensitivity but with relatively low specificity in diagnosis of coronary artery disease in patient with acute coronary syndrome.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: صدى القلب
السنة: 2018
الموضوع العام: الطب
اسم المشرف: نزار ناصر عباس العتابي
اسم المؤلف: عماد محمود حسين

صلاحية فحوصات الفسلجة العصبية بتنبؤ شدة متلاكمة غوليان باري وباستحقاق التنفس الاصطناعي Validity of neurophysiological study in prediction of severity of Guillain - Barre syndrome and the indication for mechanical ventilation

المستخلص: Guillain - Barre syndrome is an acute monophasic, non - febrile postinfectious illness manifesting as ascending weakness, and areflexia.However, sensory, autonomic and brainstem abnormalities may also seen. It is one of the most common causes of acute motor paralysis. In addition to the clinical presentation, those patients may develop neurophysiological features suggestive of demyelinating neuropathy.However, an axonal form had been reported. Hence, the importance of electrophysiological study; nerve conduction study (NCS) and electromyography (EMG) in the neurological evaluation of the severity of Guillain - Barre syndrome and the indication for mechanical ventilation.This study aimed to evaluate the neurophysiological study in prediction the severity of GBS, assess the usefulness of neurophysiology in prediction of respiratory muscles involvement and find out whether the neurophysiological study of peripheral nerves can predict the indications of mechanical ventilation.Two groups of patients are involved in this study. 22 Patients with GBS in the neuromedical wards and 18 patients in the respiratory care units (RCU).The mean age of the two groups were (47+\ - 24 years) with female predominance (1.22 : 1).Each patient submitted to brief medical history, clinical examination and neurophysiological study. This study was conducted at the neuromedical wards and RCU departments of Hospital of neurosciences, Baghdad and ALyarmuk teaching hospitals in a period from December 2017 to June 2018.The neurophysiological assessments involve the following tests : 1. Sensory NCS of bilateral median, ulnar and sural nerves involve sensory latency and sensory nerve action potential (SNAP). 2. Motor NCS of bilateral median, ulnar, common peroneal and tibial nerves involve the motor latency, compound motor action potential (CMAP), motor nerve conduction velocity (MNCV), conductions block and temporal dispersion.3. Minimal F wave latency of bilateral median, ulnar, common peroneal and tibial nerves.4. Needle EMG for bilateral proximal and distal muscles of upper (first dorsal interosseous) and lower limbs (tibialis anterior and extensor digitorium brevis) in which insertional activity, spontaneous activity, motor unit action potential MUAP and interference pattern were applied.The results of this study reveal that F wave and distal motor latencies of the left median, left ulnar, left peroneal, left tibial, right ulnar, right peroneal and right tibial nerves are significantly different between studied groups. Where there are prolonged latencies which could be considered as an indicator for admission to the RCU.Moreover, the reduced compound motor action potential (CMAP) and decrease conductive velocity (CV) in nearly all nerves are significantly different between studied groups and can also increase the chance for admission to the RCU.Concerning sensory abnormalities recorded in this study there are a reduced sensory nerve action potential of left median nerve or a prolonged left ulnar sensory latency when compared to the right ulnar and median sensory study and also increase the risk for admission to the RCU. Interestingly, what was noticed in this study, there are asymmetrical findings in nerve conductive parameters of the same patient involving not only the motor nerves rather than the sensory nerves too.This study concluded that the neurophysiological study can predict the severity of Guillain - Barre syndrome mainly the prolongation of F wave and motor latencies. The peripheral neurophysiological findings are useful in prediction of respiratory muscles involvement by GBS depending on CMAP and conductive velocity. There are asymmetrical finding changes in the studied neurophysiological parameters more apparently involving the sensory nerves of the same patients. Extremes of an age (<30yrs and >50yrs) represent a risk factor if not an indicator for RCU admission.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: الفسلجة العصبية
السنة: 2018
الموضوع العام: الطب
اسم المشرف: نجیب حسن محمد زكي نوح حسن
اسم المؤلف: بلال صادق عبد الباقي

تعدد الاشكال الجيني للكالكتين - ? في مرضى التهاب المفاصل الروماتويدي Galectin - 8 Gene Polymorphism In Rheumatoid Arthritis Patients

المستخلص: التهاب المفاصل الروماتويدي هو مرض التهاب المفاصل الالتهابي المزمن مع معدلات كبيرة للمراضة والوفيات .التشخيص المبكر مهم للمعالجة وتحقيق افضل النتائج . لقد اجريت هذه الدراسة في الفترة ما بين بداية تشرين الثاني عام 2016 وحتى نهاية تشرين الثاني عام 2017 على 90 شخصا تم تشخيص 50 منهم على انهم مصابين بالتهاب المفاصل الروماتويدي (مجموعة المرضى) الذين كانوا يحضرون للعيادة الخارجية للمفاصل بمستشفى بغداد التعليمي وكان هناك ايضا 40 اخرون من مجموعة الاصحاء. تم جمع عينات الدم من المرضى والاصحاء لاكتشاف تعدد الاشكال الجيني للكالكتين - 8 والذي تم اجراؤه بواسطة تفاعل سلسلة البوليميريز الخاص بتضخيم الطفرة (ARMS - PCR)كما تم تقييم مستوى الكالكتين - 8 والاجسام المضادة لل CCP في مصل الدم بواسطة مقايسة الممتز المناعي المرتبط بالانزيم ELISA)). تم قياس بروتين سي التفاعلي( CRP) بواسطة nephlometer كما تم فحص العامل الروماتويدي RF) ) بواسطة طريقة تراص اللاتكس . كان مجموع مرضى الدراسة الحالية 50 مريضا، كان متوسط اعمارهم (10.4±46.5) سنة ، وكانت نسبة الاناث سائدة اكثر من الذكور في نسبة (F : M 2.6 : 1). لقد اوضحت الدراسة الحالية انه لم يكن هناك اختلاف كبير بين المرضى والاصحاء في ما يتعلق بتعدد الاشكال الجيني للكالكتين - 8 وكشفت الدراسة الحالية ان مستوى الكالكتين - 8 كان اعلى في مجموعة الاصحاء (87.83 ± 182.93) من مجموعة المرضى ( 36.68± 25.79 ) وهذا الفرق ذو دلالة احصائية (P<0.001 ) ,في ما يتعلق بالاجسام المضادة للCCP فقد تم اكتشافها في 45 من المرضى بينما كانت سالب في جميع عناصر مجموعة الاصحاء والفرق كان ذو دلالة احصائية P <0.001 ) ) ,كما اظهرت الدراسة ان بروتين سي التفاعلي كان موجبا في 25 مريضا وفي 11 فردا من مجموعة الاصحاء وهذا الفرق ذو قيمة احصائية (p= 0.03), كما كشفت النتائج الحالية ان اختبار العامل الروماتويدي كان موجبا في 25 مريضا وكذلك 9 افراد من مجموعة الاصحاء وهذا الفرق ذو دلالة احصائية (p= 0.007) ,كما ان معدل ترسيب الدم لمجموعة المرضى اعلى من مجموعة الاصحاء وذو دلالة احصائية عالية (P <0.0001 ) . لقد اوضحت الدراسة انه لم يكن هناك اي اختلاف ملحوظ بين مجموعة المرضى ومجموعة الاصحاء فيما يتعلق بتعدد الاشكال الجيني للكالكتين - 8كما بينت الدراسة ان لمستوى الكالكتين - 8 في مصل الدم نتائج ممتازة للتمييز بين مجموعة المرضى ومجموعة الاصحاء.ان مستويات الكالكتين - 8 كانت اعلى في مجموعة الاصحاء من مجموعة المرضى , كان هناك ارتباط كبير سلبي بين مستويات الكالكتين - 8 والاجسام المضادة للCCPومعدل ترسيب الدم والعامل الروماتزمي وهذا يشير الى ان مستوى منخفض من الكالاكتين - 8 يرتبط بشكل كبير مع مستوى عال ( مستوى متزايد) من الاجسام المضادة للCCPومعدل ترسيب الدم والعامل الروماتويدي ، وبالتالي يمكن ان يشير الى نشاط المرض وشدته. | Rheumatoid arthritis is chronic inflammatory arthritis disease with significant morbidity and mortality .Early diagnosis is important for beter treatment and outcome. Galectins are potent immune regulators and modulate a range of pathological processes, such as inflammation, autoimmunity, and cancer, Accumulated evidence shows that several family members of galectins play positive or negative roles in the disease development of RA, through their effects on T and B lymphocytes, myeloid lineage cells, and fibroblast - like synoviocytes. This case controls study assess the association between serum galactin - 8 gene polymorphism in RA and controls .And also measure the serum level of Galectin - 8 in RA patient and controls and its validity in early diagnosis. Patients and Methods : This study was conducted in the period between November 2016 till the end of November 2017 on ninety (90) subjects, fifty (50) of them (patient group) were diagnosed as established RA patients, who were attending the Rheumatology Outpatient Clinic of Baghdad Teaching hospital, and other forty (40) were apparently healthy control group. Blood samples were collected from patients and controls to assess serum galectin - 8 and ACCP by enzyme linked immunosorbent assay (ELISA), the CRP was measured by nephlometer, and RF by latex agglutination method, Whereas Galectin - 8 gene Polymorphism done by Amplification - Refractory Mutation System - PCR (ARMS - PCR).Results : 50 case study group included in the current study, their mean age 46.5±10.4 years, the females were predominant than males in a ratio (F : M 2.6 : 1). The current study revealed that serum levels of galectin - 8) higher in control group (182.93±87.83) than patient group (36.68±25.79) and this difference is statistically significant (P - value < 0.001).At the optimum cut off value of serum gal - 8 ≤ 95.7 we found that maximum accuracy was 95.6 , sensitivity 98.0%, specifity 92.5% and AUC was 0.971 this indicate that the biomarker has excellent valid results to differentiate bet patient and control. In the present study there was negative significant correlation between serum galectin - 8 and ESR,ACCP,RF. there was no significant difference between patients and controls regarding galectin - 8 gene polymorphism. TT allele had the highest association with RA while AT allele had the weakest association with RA, however; all these alleles did not associated significantly with RA.Anti - CCP antibodies were detected in 45 (90.0%) patients and were not detected only in 5 (10.0%) patients. Out of 40 healthy controls; the anti - CCP was negative in all healthy controls (100.0%), , with extremely statistical difference (P <0.001) between the patients and healthy control group. The present study showed that CRP was positive in 25 patients (50.0 %), and in 11 subjects (27.5%) from control group and this difference is statistically significant p - value= 0.03The present findings revealed that RF test was positive in only 25 patients (50.0%), and was positive in nine subjects (22.5%) from control group and this difference was statistically significant (P - Value = 0.007 ), Mean level of ESR of patient group higher than control group and is highly statistically significant (P - Value < 0.0001).Conclusions : The study shown that there was no significant difference between patient and controls regarding galectin - 8 gene polymorphism, and there was significantly less serum galectin - 8 in patient compared to control, also there was negative significant correlation between serum galectin - 8 and ESR,ACCP,RF.At the optimum cut off value of serum gal - 8 ≤ 95.7 we found that maximum accuracy was 95.6 , sensitivity, specifity and AUC was 0.971 this indicate that the biomarker has excellent valid results to differentiate between patient and control
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
السنة: 2018
الموضوع العام: الطب
اسم المشرف: محمد عبد الاخوة الفحام فائق ايشو كوريال
اسم المؤلف: طارق قادر طلاب

تاثير التدخين المزمن على وظائف البطين الايمن للقلب لدئ فئة الذكور الشباب : دراسه صدئ القلب بطريق تعقب الوصلة النقطية للاجهاد The Effects of Chronic Cigarette Smoking on the Right Ventricular Functions in Young Male Subjects : A Speckle Tracking Echocardiographic Study

المستخلص: الخلفية : يعتبر التدخين المزمن واحدا من اهم عوامل الخطورة للاصابة بامراض الشرايين التاجية ومع ذالك فان له تاثيرات جانبية اخرى على القلب غير معتمدة على تصلب الشرايين.الهدف من هذه الدراسة : لتقييم الاعراض الجانبية المحتملة من التدخين المزمن على وظاىف البطين الايمن للقلب الانقباضية والانبساطية بتعقب الوصلة النقطية للاجهاد بواسطة جهاز صدى القلب ثنائي الابعاد.طرائق البحث : تم اجراء هذه الدراسة في مستشفى بغداد التعليمي شعبة القسطرة \وحدة الايكو للفترة من حزيران 2017 الى ايار 2018 .حيث تم تقسيم المشاركين الى مجموعتين ,مجموعة المدخنين ومجموعة غير المدخنين وتم اجراء فحص صدى القلب للماشركين حسب البروتوكول القياسي ومن ثم تعقب الوصلة النقطية للاجهاد بواسطة صدى القلب ثنائي الابعاد لتقييم الاجهاد الطولي العام للبطين الايمن من القلب . النتائج : اربعين حالة من الذكور الشباب مع اربعين حالة مراقبة مطابقة في العمر تم تسجيلهم في هذه الدراسة حيث كانت الخصائص الاساسية لكلا المجموعتين متشابهة.وكان هنالك اختلاف بشكل ملحوظ للانحراف الانقباضي للحلقة الطائرة لثلاثي الحراشف (قيمه 0.04 > P) حيث انه كان منخفض بشكل ملحوظ لدى مجموعة المدخنين. قمة السرعة الانبساطية المتاخرة( موجه A )كانت مرتفعة بشكل ملحوظ لدى مجموعة المدخنين (قيمه 0.016 > P) وبالتالي فان نسبة قمة السرعة الانبساطية المتقدمة الى قمة السرعة الانبساطية المتاخرة كانت منخفظة بشكل ملحوظ لدى هذه المجموعة(قيمه 0.017 > P). ان تصوير الدوبلر للانسجة لجدار البطين الايمن الحر اظهر ان قمة السرعة الانقباضية لجدار البطين الايمن الحر وقمة السرعة الانبساطية كانتا منخفظتان بشكل ملحوظ لدى مجموعة المدخنين مقارنة بمجموعة المراقبة(قيمه 0.02 > P للحالتين ). وان الاجهاد الطولي العام كما تم تقييمه بتعقب الوصلة النقطية للاجهاد بواسطة جهاز صدى القلب ثنائي الابعاد كان منخفظا بشكل ملحوظ لدى مجموعة المدخنين (قيمه 0.04 > P). كانت هنالك علاقة مترابطة بشكل ملحوظ بين كمية التدخين والاجهاد العام للبطين الايمن بتعقب الوصلة النقطية للاجهاد بواسطة جهاز صدى القلب ثنائي الابعاد.الاستنتاج : اظهرت هذه الدراسة ان التدخين المزمن يسبب تغييرات في الوظائف الانقباضية الطولية والوظائف الانبساطية لبطين القلب الايمن لدى فئة الذكور الشباب وان هذه التغييرات يمكن اكتشافها بصورة مبكرة بتعقب الوصلة النقطية للاجهاد بواسطة صدى القلب ثنائي الابعاد. | Background : Chronic Cigarette smoking is one of the major risk factors for coronary artery disease. However, it has additional cardiac adverse effects independent of coronary atherosclerosis.Objectives of study : To assess the effects of chronic smoking on right ventricular systolic and diastolic functions using Two - Dimensional Speckle Tracking.Patient and methods : This study was carried out in Baghdad Teaching Hospital\ Echo unit from June 2017 to May 2018.The participants whom divided into two groups smoker vs nonsmoker were examined by standard echocardiography protocol which was followed by Two - Dimensional Speckle Tracking to assess the functions of the right ventricle.Results : Forty young smokers’ men and 40 age - matched nonsmoking controls enrolled in this study, the baseline characteristics of two groups were similar. There were significant differences regarding the Tricuspid Annular Plane Systolic Excursion ,P (<0.04) which were significantly reduced in smokers group. The peak late diastolic velocity (A wave) were significantly higher in smoker group P (0.016) and hence the E/A ratio were significantly lower P (0.017). The Tissue Doppler Imaging examination of right ventricular free wall reveal that the Peak systolic velocity of RV free wall (S’), and the peak early diastolic velocity of RV free wall (E’) were found significantly lower in smokers group when compared to control group (P <0.02 for both ). The Global Longitudinal Strain as assessed by 2D - Speckle Tracking Echocardiography were also significantly reduced in smoker group P (0.04). There were significant correlations between the amount of smoking and right ventricular global strain by 2 - D Speckle Tracking Echo study.Conclusion : This study demonstrated that chronic cigarette smoking causes alterations in long - axis systolic and diastolic functions of right ventricle in healthy young subjects. These changes can be early detected with 2 - D Speckle Tracking Echocardiography
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الامراض - القلب
السنة: 2018
الموضوع العام: الطب
اسم المشرف: معتز فوزي حسين
اسم المؤلف: شهيد حميد عيدان

تقييم التشخيص الكهروفسلجي الناتج عن خلل الوظيفة اللا ارادية في مرضى داء السكري ELECTRODIAGNOSTIC EVALUATION OF AUTONOMIC DYSFUNCTION IN DIABETES MELL

المستخلص: Diabetic autonomic neuropathy is a serious and common complication of diabetes. The most studied and clinically important form of diabetic autonomic neuropathy is cardiovascular autonomic neuropathy.Aim of study : To assess the autonomic dysfunction in diabetics electrodiagnoctically using reliable tests by sympathetic skin response and R - R interval tests.A cross - sectional study was conducted in the Electromyography unit in Baghdad Teaching Hospital between (Feb/1/2018 - May/15/2018). It included all adult male and female with symptoms of neuropathy or autonomic dysfunction. Pregnant women were excluded from the study. Neurological tests were performed as sympathetic skin response, and R - R interval including normal and deep breath, Valsalva and tilt tests).Means of sympathetic skin response amplitude, R - R interval (Valsalva), and R - R interval (tilt) tests were significantly higher in non - diabetic patients than diabetics (2.19 versus 0.541, P= 0.001; 1.75 versus 1.48, P= 0.017; and 1.44 versus 1.01, P= 0.002 respectively). They were also significantly higher in controlled than in uncontrolled diabetic patients (1.69 versus 0.15, P= 0.044; 1.99 versus 1.31, P= 0.039; and 1.23 versus 0.941, P= 0.022 respectively). Cut points of these tests between controlled and uncontrolled diabetic patients were (0.81, 1.84, and 1.04 respectively). This mean that all patients with tests below these values can be considered uncontrolled diabetics.Sympathetic skin response amplitude, and R - R interval tests are good electro diagnostic tests to evaluate the autonomic dysfunction affected by diabetes, and to assess the severity of autonomic dysfunction in uncontrolled diabetes and differentiating them from those with controlled diabetes.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: الفسلجة
السنة: 2019
الموضوع العام: الطب
اسم المشرف: عبد الناصر حسين امير
اسم المؤلف: نهال مهند لطفي

التقييم الوظيفي للبطين الايمن في مرضى ارتفاع الضغط الشرياني باستخدام تقنية شدة صدى القلب Physiological Assessment of Right Ventricular Function in Patients with Systemic Hypertension Using Strain Echocardiography

المستخلص: البطين الايمن او البطين المنسي هو عبارة عن حجرة ذات شكل غير منتظم وتركيب هندسي معقد . على الرغم من ان التركيز كان في السابق على الجزء الايسر من القلب من الناحية الوظيفية والمرضية ، فهناك عدد متزايد من الادلة على اهمية البطين الايمن وخاصة اهميته في الحفاظ على استقرار الدورة الدموية للجسم ، مستوى النشاط في المرضى الذين يعانون من قصور القلب المزمن ومدى التحسن في المرضى الذين يعانون من امراض صمامات القلب.ارتفاع ضغط الدم الشرياني هو مشكلة صحية عامة رئيسية واسعة الانتشار على المستوى العالمي. تعرف امراض القلب الناتجة عن ارتفاع ضغط الدم باعتلال عضلة القلب الناتجة عن استجابة عضلة القلب للاجهاد الميكانيكي الناتج عن ارتفاع ضغط الدم وتاثير الهرمونات العصبية وعوامل النمو التي تؤدي الى تشوهات متنوعة تشمل تضخم البطين الايسر , الاضطراب الانقباضي والانبساطي ، ومضاعفاتها السريرية بما في ذلك عدم انتظام ضربات القلب وقصور القلب.في دراسة صدى القلب للبطين الايمن ، يجب اجراء التقييم الشامل باستخدام نوافذ صوتية متعددة وتقنيات مختلفة. ان طريقة تتبع البقع الصغيرة باستخدام تخطيط صدى القلب ثنائي الاتجاه هي طريقة جديدة لحساب تشوه عضلة القلب في الصور القياسية ذات المقياس الرمادي حيث كل قطعة صغيرة من عضلة القلب في صورة تخطيط صدى القلب لديها نمط فريد خاص بها من البقع.كان الهدف من هذه الدراسة هو : تقييم تاثير ارتفاع ضغط الدم الشرياني على وظيفة البطين الايمن الانقباضي والانبساطي مقارنة مع المجموعة الضابطة وتحديد تاثير ارتفاع ضغط الدم الشرياني على ميكانيكة البطين الايمن بقياس قيمة التشوه الطولي ثنائي البعد .وكان العدد الاجمالي المشمول في الدراسة ( 200 ) شخص من كلا الجنسين ( 118 من الرجال و82 من الاناث ) ، تتراوح اعمارهم من ( 40 - 60 ) سنة ، وتم تقسيمهم الى مجموعتين : 1 - 100 شخص من المرضى الذين يعانون من ارتفاع ضغط الدم الشرياني . 2 - 100 شخص من الاشخاص الاصحاء يمثلون المجموعة الضابطة. وقد تم اخذ التاريخ الطبي الكامل ، تخطيط القلب الكهربائي , قياس ضغط الدم , تصوير الصدر بالاشعة السينية وقياسات الطول والوزن لكل الاشخاص , تم اجراء تخطيط صدى القلب لجميع الاشخاص باستخدام جهاز GE Vivid E9® .نتائج هذه الدراسة اكدت وجود فرق معتد من الناحية الاحصائية فيما يتعلق بوظيفة البطين الايمن الانبساطية بين مجموعة المرضى والمجموعة الضابطة ( P = 0.001 ) .وفيما يتعلق في قياس قيمة التشوه في البطين الايمن كذلك اكدت الدراسة انخفاض قيمة التشوه في البطين الايمن للمرضى مقارنة بالمجموعة الضاغطة وكان الفرق معتد من الناحية الاحصائية ( P = 0.001 ) .و كشفت الدراسة ان نسبة الارجحية من الانحدار اللوجستي متعدد المتغيرات ان سمك الحاجز بين البطينين كان المؤثر الاكبر على قيمة التشوه في البطين الايمن .نتائج هذه الدراسة وضحت انخفاض نسبة التشوه الطولي للبطين الايمن وبالتالية تاثر الوظيفة الانقباضية عند مجموعة المرضى وعلاقة هذا التاثر القوية مع تضخم الحاجز بين البطينين الشيء الذي لم تستطع الفحوصات التقليدية في اكتشافه | The right ventricle or the forgotten chamber is multi - compartmental in orientation with a complex structural geometry. Although the focusing in cardiology was placed on left heart physiology and pathology in the past, there is a growing body of evidence for the importance of the RV especially the maintenance of normal body hemodynamics, exercise capacity in chronic heart failure and survival in patients with valvular heart disease. Arterial hypertension is a major public health problem due to its high prevalence globally. Hypertensive heart disease is the cardiomyopathy which result from myocardial response to the mechanical stress from elevated blood pressure , the influences of neurohormones , growth factors, and cytokines and then leads to variety of abnormalities includes left ventricular hypertrophy (LVH), systolic and diastolic dysfunction, and their clinical complication including arrhythmias and heart failure .In echocardiographic studies, a comprehensive assessment of the right ventricle should be performed using multiple acoustic windows and different image techniques .The two dimensions speckle tracking echocardiography is a novel non - invasive echocardiographic method to calculate myocardial deformation in standard grey - scale images in which every little piece of myocardium in echocardiography image has its own unique pattern of speckles. The aim of this study was to : evaluate the effect of systemic arterial hypertension on systolic and diastolic right ventricular function and to determine the effect of systemic arterial hypertension on right ventricle mechanics using two dimensional longitudinal strains.The total number of hypertensive patients and apparently healthy control subjects were (200) of either sex (118 male and 82 female), their age range from (40 - 60) year; they were divided into two groups : 100 Patients with hypertension, 100 apparently healthy control subjects. Each patient and control subject was submitted to full medical history, physical examination, ECG, chest X - Ray, blood pressure determination and subject’s anthropometry measurements. Echocardiography was performed for all subjects using a GE Vivid E9® system in which M - mode, two dimensional , color, pulse and continuous wave Doppler , tissue Doppler and speckle tracking imaging were obtained according to the American Society of Echocardiography guideline of using Echocardiography in Adult Hypertension.Trans - tricuspid E/A ratio was decreased in hypertensive group (1.10±0.12) versus (1.39±0.28) in normotensive group with statistically significant difference p value =0.001. The mean tricuspid E/ é ratio was (4.95±1.34) in hypertensive patients while was (3.90±0.98) in control group, the p value was 0.001 and there was significant difference between them. It was observed that the mean 2D - RVGLS was ( - 20.12 ± 3.80) % in hypertensive patients versus ( - 25.90 ± 2.18) in normal subjects, the P value was 0.001 and there was significant difference between the two groups. The odds ratio of multivariate logistic regression revealed that the diastolic interventricular septum thickness was the strongest factor affect RVGLS in this study, odds ratio for IVSD, RWT, and LVPW were respectively 2.418, 1.978, and 1.761. This study conclude that RV longitudinal strain is significantly impaired in hypertensive patients group and strongly correlates with heart remodeling and it is superior to more conventional functional parameters of RV systolic function.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
الموضوع الدقيق: الفسلجة
السنة: 2019
الموضوع العام: الطب
اسم المشرف: حنان لؤي العمري غازي فرحان حاجي
اسم المؤلف: حيدر عامر توفيق

دراسة تنشيط النطف البشرية باستخدام الوسط الزرعيHam's F - 12 ومادة البومين المصل البشري لمرضى العقم An in vitro human sperm activation study Using Ham’s F - 12 medium and human serum albumin for infertile patients

المستخلص: تهدف هذه الدراسة الى التحقق من كفاءة الوسط الزرعي (Ham's F - 12) كوسط لتحضير النطف, كذلك فعالية مادة البومين مصل الدم البشري ( (Human serum albumin; HSA كمادة منشطة للنطف لاستخدامها في عمليات التنشيط لمرضى العقم. شملت هذه الدراسة مائة واربعون مريضا من المصابين بالعقم بسبب وهن النطف(Asthenozoospermia) او قله عدد النطف) (Oligozoospermiaاو كلاهما) (Oligoasthenozoospermia. كان معدل اعمارهم هو) 4.32±35.62 (عاماومعدل فترة العقم هو (6.06±0.22) سنة. تمت الدراسة في مستشفى الحسين العام وعيادة المصطفى الطبية الشعبية في كربلاء واستغرقت للفترة من شهر تموز 2006 الى شهر تشرين الثاني 2006 .تم تنشيط النطف خارج الجسم ( (in vitro sperm activation حيث استخدم الوسط الزرعي ( (Ham's F - 12 كمجموعة سيطرة(ضابطة) واستخدمت ثلاث تراكيز من مادة ( (HSA 5% و7.5% و10% وبفترتي حضن 15 و30 دقيقة. قسمت نماذج المني الى قسمين حيث حضرت المجموعة الاولى( 70 نموذج ) بتقنية النبذ والسباحة Centrifugation swim - up technique)) والسبعون الاخرى بتقنية السباحة المباشرة (Direct swim - up technique).تم فحص السائل المنوي لجميع المرضى قبل عملية التنشيط ثم قورنت النتائج مع نتائج بعد التنشيط ولجميع المرض وقورنت كذلك بعد استخدام التراكيز الثلاث المضافة من مادة ( (HSA . اظهرت النتائج ايجابية الوسط الزرعي Ham's F - 12) )لاستخدامه كوسط لتحضير النطف حيث لوحظ زيادة في حركة النطف , وكذلك زيادة في نسبة فعالية النطف A,B وكذلك زيادة في نسبة النطف السوية . كذلك لوحظ زيادة في حركة ونسبة فعالية النطف A, B وزيادة في نسبة النطف السوية ايضا بعد اضافة مادة ( (HSA وكان التركيز الافضل هو 5% وبفترة حضن 30دقيقة . وان افضل النتائج كانت للمرضى المصابين بوهن النطف مقارنة مع نتائج المرضى المصابين بقلة النطف او بقلة ووهن النطف. نستنتج من هذه الدراسة ان الوسط الزرعي Ham's F - 12) ) ذو فعالية جيدة كوسط لتنشيط النطف كما ان مادة الالبومين( (HSA يمكن استخدامها كمادة منشطة للنطف للمرض المصابين وهن النطف. | medium as sperm preparation medium and the effectiveness of human serum albumin HSA as sperm stimulator in in vitro human sperm activation for infertile patients. One hundred forty (140) infertile males were shared in present study. The mean ages of infertile males were 35.62± 4.32 years. The mean duration of infertility of them was 6.06 ±0.22 years with range of 1 - 11 year.Ham’s F - 12 medium was used as control group and three different concentrations of HSA were used (5%, 7.5% and 10%), with two incubation periods (15 and 30 minuets). Seventy semen samples were prepared using centrifugation swim - up technique, and the other seventy semen samples prepared using direct swim - up technique. The comparison was done between parameters of semen of all treated groups post - activation with pre - activation parameters and control group (Ham’s F - 12 medium).The results of the present study showed that a significant improvement in seminal fluid analysis parameters especially sperm concentration, percentage of sperm agglutination and round cells concentration were reduced significantly (P<0.01) in both technique. In contrast, percentages of sperm motility, progressive sperm activity (grades A and B) and normal sperm morphology were increased significantly (P<0.05) using both techniques.With the usage of Ham’s F - 12 medium also significant enhancement were reported in compared to pre - activation Sperm concentration, sperm agglutination percentage and round cells concentration were reduced significantly(P<0.01) in both techniques. On the other hand, percentage of sperm motility, percentage of progressive sperm activity (grades A+B) and normal sperm morphology (%) were increased significantly (P<0.05) using both techniques.The results showed that the addition of HSA to the culture medium enhances sperm motility (%), percentage of progressive sperm activity (grades A and B) and normal sperm morphology (%) using both techniques. Moreover, the best results were reported with 5% HSA and 7.5% HSA after 30 minutes of incubation. In addition to that, the results of sperm activation were better with asthenozoospermic patients than oligozoospermic and oligoasthenozoospermic patients
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: النسائية والتوليد
السنة: 2007
الموضوع العام: الطب
اسم المشرف: محمد باقر محمد رشاد فخر الدين
اسم المؤلف: محمد حسن شعبان

تقييم كثافة المعادن العظمية وكتلة العجاف والكتلة الدهنية في المراة قبل وبعد انقطاع الطمث : دراسة مقارنة Evaluation of Bone Mineral Density, Lean Mass and Fatty Mass in Pre and Postmenopausal Women A Comparative Study

المستخلص: The body composition (BC) describes the different components that makeup the human being and refers to the proportion of fat and fat - free mass inthe body. Aging processes are natural complex physiological alteration in thebody associated by weakness of the structure and functions in the organs.The alterations in body composition that occur with the aging process nothappen homogeneously. Although there are various techniques forassessment of body composition in research and clinical settings, DualX - ray absorptiometry (DXA) is the most commonly used methods forexamination and also preferred choice and golden clinical tool for thediagnosis of osteoporosis and assessment of its severity. This equipment isnoninvasive, widely available and currently the scanning of hip and spineused as the gold standard by a major number of clinicians. In recent years,there has been an increasing interest in BC measurement to assess the health.This is the first study in Iraq to assess healthy subjects.Objectives : to evaluate the changes of bone mineral density and fatty massand lean mass in postmenopausal period and to correlate them withanthropometric measurements. Also to correlate between BMD with serumcalcium, phosphate and alkaline phosphatase.Subjects and methods : This cross - sectional study was conducted at DXAUnit in Baghdad Teaching Hospital from November 2016 to December2017. Data were collected from (120) postmenopausal female subjects and(120) premenopausal female subjects with total of 240 females from age of40 - 69 years were randomly selected from the patients attending DXA unit inBaghdad Teaching Hospital. The postmenopausal female subjects weredefined as individuals with menopause at least one year since the last naturalmenstruation. Osteoporosis was diagnosed according to WHO criteriaIIT - score was used for postmenopausal subjects and Z - scores forpremenopausal subjects. Women were excluded from the study if they anycondition may affect the BMD or other constituents of BC.Results : a highly significant lower BMD of lumbar spine and both femurswere found in postmenopausal group. Although the mean of areas of ribs, lumbar spine, pelvis, legs and total body fat mass were higher in postmenopausal subjects but no significantly differences of body fat mass g̸cm² measured by DXA between the postmenopausal and premenopausal subjects. A highly significant difference of LM g ̸cm² measured by DXA between the postmenopausal and premenopausal subjects (p - value0.0004 - 0.001) in measurements of total LM and anatomical areas. Significant effects were found of total FM and total LM on BMD of lumbar spine and neck of both femurs in postmenopausal subjects but LM had more effect than FM.Conclusion : A highly significant lower BMD and LM were found with increased adiposity among postmenopausal women. Both FM and LM affect BMD of lumbar spine and both femurs but LM had more effect
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الفسلجة
السنة: 2018
الموضوع العام: الطب
اسم المشرف: غسان ثابت سعيد فائق ايشو كوريال
اسم المؤلف: علي حسين فالح

مرض التدرن في مركز الامراض الصدرية والتنفسية في مدينة بلد صفات المرضى والنتائج منذ 2016 بعد البدء باستعمال الفحص الجيني للتشخيص ومعرفة المقاومة لعقار الريفامبسين Tuberculosis in Pulmonary Diseases Center in Balad City, Patient characteristic and Outcome Since 2016 after Start Using MTB_RR Xpert gene

المستخلص: Tuberculosis is a deadly infectious disease that caused around 1.7 million deaths in 2016 worldwide. X pert MTB - RR assay is a new test that is revolutionizing tuberculosis control by contributing to rapid diagnosis of disease and drug resistance.Objectives : To study tuberculosis patient characteristics, drug resistance, reaching conclusions about proper measures to control TB, and highlight importance of the new diagnostic method X - pert gene MTB - RR.Method : Cross sectional study was conducted among patient diagnosed with tuberculosis in Balad pulmonary disease center from January, 2016 to May,2018 using Gene X - pert as main diagnosis method, patient's characteristics were studied and information were analyzed using SPSS.Result : Tuberculosis incidence in Balad district was (40/100000) in 2017, and 6.9%(11/158) of patients in the study were found to had Rifampicin resistance.X - pert gene MTB - RR was found to be 100% sensitive and 85% specific Most important risks for relapse in tuberculosis patients with statistically significant p - value were diabetes, low level of education and far distance from health center. Conclusion : Gene X - pert MTB - RR is simple, rapid and accurate test for diagnosis of Tuberculosis and rifampicin resistance.Diabetes have significant statistically association with tuberculosis and relapse rate and this subgroup of patients need special care from TB health workers.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: طب العائلة
السنة: 2018
الموضوع العام: الطب
اسم المشرف: نادية عزيز ناصر
اسم المؤلف: زينب اكرم سالم

تاثير الخدمات الصحية على وفيات الولدان في بغداد 2012 - 2016 The Impact of Health Services on Neonatal Deaths in Baghdad, 2012 - 2016

المستخلص: الخلفية : وفيات الاطفال حديثي الولادة مؤشر لجودة الخدمات الصحية للام والطفل في المجتمع والوضع الاقتصادي. العراق لازال يعاني من حروب ووضع اقتصادي مزري نتيجة حصار سابق وانخفاض اسعار النفط وسيطرة الارهاب على اراضيه، وتزايد عدد النازحين داخل البلد. وظهرت تلك الاشكالات الاجتماعية على شكل صراعات.الاهداف : اجريت هذه الدراسة لمراجعة نسبة وفيات الاطفال حديثي الولادة في المستشفى حماية الاطفال التعليمي ومستشفى الاطفال الكاظمية من 2012 الى 2016..الطرق : جريت دراسة مستعرضة باثر رجعي. مستشفيات عشوائية مختارة من كل جانب من بغداد ، المستشفى حماية الاطفال التعليمي فيجانب الرصافة من مدينة بغداد ومستشفى الاطفال الكاظمية في جانب الكرخ من مدينة بغداد. تم جمع جميع سجلات حالات حديثي الولادة في وحدات الرعاية المركزة للولدان من عام 2012 الى عام 2016 في المستشفيات المذكورة. تحتوي السجلات على بيانات حول حديثي الولادة . ومن سجلات الادارة تم الحصول على اعداد الاطباء والكادر التمريضي ومن سجلات القسم الفني على اعداد الاجهزة الطبية.ظهرت الخدمات الصحية في عدد من اطباء اختصاص اطفال واطباء الدراسات العليا والكادر التمريضي الجامعي.النتائج : زيادة في دخولات حديثي الولادة في نهاية السنوات المدروسة بنسبة 25.9 ٪. كانت هناك زيادة في نسبة اطباء الاطفال ونسبة اطباء الدراسات العليا ونسبة الممرضين المتخرجين بمقدار 0.004 و0.2 و0.02 على التوالي. لم تتاثر نسبة وفيات المواليد الجدد بعدد اطباء الاطفال (P = 0.3) ، وطبيب الدراسات العليا (P = 0.2) ، وممرضة الدراسات العليا (P = 0.02). الاستنتاج : لوحظ ارتفاع معدل وفيات الولدان. الصراعات اثرت سلبا على الخدمات الصحية، واظهرت اسباب غير واضحة لذلك. | Background : Neonatal mortality is an indicator to evaluate and assess the maternal and neonatal health services system in the community. Neonatal mortality reflects the quality of socioeconomic status and health services of each country.Iraq has been suffering from wars, economic sanction, and internal displacement population.Conflicts lead to deterioration in health system which is in turn affect health status.Objectives : This study was carried out to review the neonatal mortality proportion in Children's Welfare Teaching hospital and Al - Kadhimiya children hospital from 2012 to 2016.Methodology : A retrospective cross - sectional study was conducted. A random chosen hospitals from each site of Baghdad, Children's Welfare Teaching hospital in Al - Rusafa side of Baghdad city and Al - Kadhimiya children hospital in Al - karkh side of Baghdad city. All cases records of newborns in neonatal intensive care units from 2012 to 2016 in the mentioned hospitals were collected. Records contain data about newborn, the health worker, and medical instrument.Health services were manifested in number of specialist pediatrician, postgraduate physicians and graduate nurse. Results : The admissions increased in the ending years of studied period by 25.9%. There was an increase in pediatrician proportion, postgraduate physician proportion and graduated nurse proportion by 0.004, 0.2, and 0.02 respectively. Neonatal mortality proportion wasn’t affected by number of pediatrician (P = 0.3), postgraduate physician (P = 0.2), and graduate nurse (P = 0.02).Conclusions : High neonatal mortality was observed. Conflicts mask the impact of the health services.Keyword : Neonatal mortality, Proportion, conflict, Iraq, neonatal intensive care unit.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: طب المجتمع
السنة: 2018
الموضوع العام: الطب
اسم المشرف: جواد كاظم الديوان
اسم المؤلف: سالي سعد محمد علي باش

مستوى فيتامين دال في الشابات العراقيات المحجبات وغير المحجبات Vitamin D Level in Veiled and Unveiled Iraqi Young Females

المستخلص: Vitamin D is one of the primary regulators of calcium (Ca) homeostasis in the body. Although a small amount of vitamin D is supplied from food, exposure of skin to the ultraviolet (UV) rays in sunlight is known to be the major source. Vitamin D is critically important for normal mineralization of bone.Aim of the studyThe aim of the study is to compare vitamin D status in veiled and unveiled healthy Iraqi women of reproductive age. Patients and methods A cross - sectional study was conducted at Baghdad TeachingHospital, Rheumatology unit. Between January and August 2018, A 100 healthy Iraqi volunteer women were recruited from the city of Baghdad at local hospitals. Informed consent was obtained from all subjects.ResultsThe laboratory testing of the serum 25 - Hydroxy vitamin D, serum calcium, serum phosphate and ALP of women in both groups revealed that veiled women had significantly lower 25 - Hydroxy vitamin D, than unveiled women.ConclusionsThe high prevalence of low vitamin D status in veiled females in comparism to unveiled females, calls for action to increase the population’s awareness and to develop strategies to reduce this risk among women, particularly those wearing dress styles that cover most or all of their skin
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الامراض - المفاصل
الموضوع العام: الطب
اسم المشرف: محمد هادي العصامي
اسم المؤلف: مهند خليل احمد

متلازمة القولون المتهيج بين طلاب المدارس الثانوية : نسبة الانتشار والاسباب 2017 - 2018 Irritable Bowel Syndrome Among High School Students : Prevalence and Determinants 2017 - 2018

المستخلص: الخلفية : ان متلازمة القولون المتهيج هي خلل وظيفي يصيب الامعاء الغليظة ويؤدي الى اعراض مزمنة في الجهاز الهضمي. وهو مرض واسع الانتشار يصيب كل الفئات العمرية لكنه اوسع انتشارا" بين فئة المراهقين والشباب.الهدف من الدراسة : هو معرفة نسبة انتشار المرض بين طلاب المدارس الثانوية وتحديد العوامل المؤثرة في زيادة نسبة انتشاره في محافظة بغداد 2017 - 2018 الاشخاص وطريقة العمل : هذه دراسة مقطعية اجريت على 12 مدرسة من المدارس الثانوية التابعة لمديريات تربية بغداد \ الكرخ. حيث تمت الدراسة عن طريق الاستبيان المباشرلاعراض المرض لجميع طلاب المرحلة السادسة في تلك المدارس , ذكورا"واناثا". وقد تم استبعاد الطلبة الذين يعانون من الاعراض التي تشير الى امراض اخرى قد تتداخل مع تشخيص المرض., وكذلك استبعاد الطلبة الذين سبق وان اجروا عملية سابقة او شخصوا باصابتهم بامراض اخرى في الجهاز الهضمي وقد تمت الدراسة بتطبيق نوعين مختلفين من الاستبيان, الاول لجمع المعلومات الاجتماعية والديموغرافية والعادات اليومية للطلبة, والاستبيان الثاني (Rome Criteria III) لتشخيص المرض ,ثم تصنيفه الى ثلاثة انواع (رابط الاسهال, رابط الامساك ,النوع المختلط) النتائج : شملت الدراسة 592 طالب وطالبة, وقد اظهرت الدراسة ان النسبة العامة لانتشارالمرض كانت 29,7% (فاصل الثقة 95% 29.4 - 30.1%) مع نسبة اعلى للانتشار بين الاناث عن الذكور بنسبة1 : 1.5 كما اظهرت الدراسة ان النوع المختلط من المرض هو النوع الاكثر شيوعا"(42.6%) يليه رابط الاسهال(33.5%), ثمرابط الامساك(23.9%). وكشف معامل الانحدار اللوجستي عوامل الخطورة التالية : الضغوط الحياتية) 3.93% (OR= والحساسية للاطعمة (2.89% OR=) والامراض المزمنة (2.22% (OR= والعامل الوراثي (2.04% OR=) والجنس (1.84% OR=) هي من اهم العوامل المؤثرة في زيادة نسبة انتشار المرض | Background : Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder. It's worldwide prevalent and causes a great challenge on the health system and patients' daily life activity. It affect all age groups but more common among adolescents and young age groups.Objectives : To estimate the prevalence and identify potential determinants of IBS among high school students in Baghdad, Iraq.Methods : This cross - sectional study was conducted on a cluster sample of 12 high schools in Baghdad. All students in the sixth grade were considered eligible. Students with "red flag" symptoms were excluded. Rome III criteria questionnaire was considered to define Irritable Bowel Syndrome. A self - administered questionnaire used to compile socio - demographics, personal habits and certain potential determinants.Statistical Analysis : Statistical Package for Social Sciences (SPSS) program, version 23 was used for data entry and analysis. The prevalence (and its 95% confidence interval) of Irritable Bowel Syndrome among high school students was calculated. Chi square and fisher's exact probability test were applied to test association of qualitative and categorical variables with IBS. Logistic regression analysis was used to identify the significant, independent and un - confounded risk factors.Result. Among 657 eligible high school students, 592 (90.1%) were enrolled. The prevalence of Irritable Bowel Syndrome was 29.7% (95% C.I. 29.4 - 30.1%). The most common type was mixed type (42.6%) followed by diarrhea - predominant (33.5%), then constipation - predominant (23.86%). Binary and logistic regression analyses revealed the following significant factors. Exposure to stressful life event (OR. 3.93; 95% CI. 2.64 - 4.85), food hypersensitivity (OR. 2.89; 95% CI. 1.59 - 3.27), chronic diseases (OR. 2.22; 95% CI. 1.24 - 3.95), family history of IBS (OR. 2.04;95% CI. 1.30 - 3.01) and female sex (OR. 1.84; 95% CI. 1.25 - 2.73). C - IBS was significantly more common among females (P=0.02) Conclusion : Irritable Bowel Syndrome is prevalent among high school students in Iraq, affected about one third of them. Stressful life events were the most important modified risk factor and it was the strongest factor affecting the prevalence of Irritable bowel syndrome. Food hypersensitivity, family history, chronic health problems and gender were the most important non - modified risk factors and Migraine was the most common comorbid chronic disease among students with Irritable Bowel Syndrome.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: طب المجتمع
السنة: 2018
الموضوع العام: الطب
اسم المشرف: فارس حسن اللامي
اسم المؤلف: هناء فريق هزاع

نتائج القسطرة القلبية لمرضى الذبحة القلبية المستقرة الذين لديهم تخطيط طبيعي او انسداد في الحزمة الكهربائية اليسرى او اليمنى CORONARY ANGIOGRAPHIC FINDINGS IN PATIENTS WITH CHRONIC STABLE ANGINA AND NORMAL ECG, LBBB OR RBBB

المستخلص: الخلفية : الذبحة الصدرية المستقرة هي احد مظاهر الاصابة بامراض القلب في حوالي 20 الى 40٪ من المرضى ، والمريض النموذجي المصاب بالذبحة الصدرية يحدث في رجل اكبر من 50 عاما او امراة اكبر من 60 عاما من العمر ، والنتائج على مخطط القلب الكهربائي (ECG)قد يكون طبيعي في نصف المرضى الذين يعانون من الذبحة الصدرية المزمنة المستقرة. هدف الدراسة : لمعرفة نتائج القسطرة القلبية لمرضى الذبحة القلبية المستقرة الذين لديهم تخطيط طبيعي او انسداد في الحزمة الكهربائية اليسرى او اليمنى.المواد والعمل : اجريت دراسة مقطعية مستعرضة في المركز العراقي لامراض القلب. في الفترة من 15 يناير 2018 الى 15 يوليو 2018 والتي شملت المرضى الذين يعانون من الذبحة الصدرية المزمنة والمستقرة ولديهم تخطيط القلب كان طبيعيا او مع انسداد في الحزمة الكهربائية اليسرى او اليمنى. خضع جميع المرضى تخطيط صدى القلب, جميع المرضى قاموا بعمل تصوير الاوعية التاجية وتم اخذ البيانات من التقارير ، ثم التحليل الاحصائي.النتائج : في الدراسة الحالية ، كان متوسط عمر المرضى الذين كان تصوير الاوعية التاجية لهم غير طبيعي 57.7، وكان معظم المرضى من الذكور ، ومعظم المرضى كانوا من الذين يعانون من مرض السكري وكذلك معضم المرضى الذين لديهم تصوير الاوعية التاجية غير طبيعي كانوا لديهم علامات نموذجية لقصور الشرايين التاجية، والمرضى الذين كان لديهم تخطيط القلب طبيعيا كان لديهم انسداد في الشريان الايسر, 66 مريض من اجمالي 156 و72 في الشريان المحيطي و45 في الشريان الايمن, واما مرضى الحزمة الكهربائية اليسرى كان هناك 18مريض لدية انسداد في الشريان الايسرمن اصل 53, و14مريض لدية انسداد في الشريان المحيطي, و8 مرضى في الشريان الايمن. واما مرضى الحزمة الكهربائية اليمنى كان لديهم 6 مرضى مصابين بانسداد الشريان الايسر من اصل 41 و4 مرضى لديهم انسداد بالشريان المحيطي و6 بالشريان الايمن.في المرضى الذين كان لديهم تخطيط القلب طبيعيا كان لديهم 85 مريض لدية انسداد في شريان واحد و43 لديهم انسداد في شريانيين و17 لديهم انسداد في ثلاث شرايين.واما مرضى الحزمة الكهربائية اليسرى كان لديهم 37 مريض لدية انسداد في شريان واحد و13 مريض في شريانين ومريضان لديهم انسداد في ثلاث شرايين.والحزمة الكهربائية اليمنى 35 مريض لدية انسداد في شريان واحد و4 مرضى لديهم انسداد في شريانيين | Background : Stable angina is one of the manifestation of ischemic heart disease in about 20 to 40 % of patients, The typical patient with angina occurs in a man> 50 years or a women >60 years of age, Findings on the resting electrocardiogram (ECG) are normal in half of patients with chronic stable angina. (1)Aims of the study : To study the coronary angiographic findings in patients with chronic stable angina and normal ECG, LBBB or RBBB.Patients and methods : A cross sectional study conducted in the Iraqi center for heart diseases. In the period from 15 January 2018 to 15 July 2018 which included patients with chronic stable angina and had normal ECG or BBB either LBBB or RBBB. All patients underwent echocardiography, the ejection fraction and contractility of the heart had reported. A special form of questionnaire had been constructed by the researcher to comprise the required data. It include the general information such as : age, gender, as well as smoking habits and history of hypertension and diabetes and history of symptoms of chest pain either typical or atypical. All patients had done coronary angiography and data had been taken from reports, then statistical analysis done. Results : In the present study mean of age of the patients with abnormal coronary angiography was 57.5, most of the patients were male, and most of the patients with DM had abnormal coronary angiography and most of the typical symptoms had abnormal coronary angiography, patients with normal ECG had LAD lesion in 66 patients from total 156 and LCX 72 and RCA 45 and in patients with LBBB 18 had LAD, 14 LCX, 8 had RCA and in RBBB 6 had LAD, 4 had LCX, 6 had RCA, and most of lesion were critical then intermediate and less for subtotal and total.In patients with normal ECG 85 had one vessel 43 had two vessel 17 had three vessel and in LBBB 37 had one vessel 13 had two vessel and 2 had three vessel and in RBBB 35 had one vessel 4 had two vessel.Conclusions1 - The most predominant artery in patients with CSA and normal ECG is LCX then LAD.2 - Most of the lesion in CSA and normal ECG, LBBB, RBBB is critical then intermediate and less subtotal and total.3 - One or two even there vessel disease could occurs in patients with CSA and normal ECG/LBBB, RBBB, but most of the cases are with one then two vessel and less for three vessel.4 - In BBB no specific artery is related to BBB although predominance was for LAD.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الامراض - القلب
السنة: 2018
الموضوع العام: الطب
اسم المشرف: حسن علي الفرحان
اسم المؤلف: زاهر عبد القادر حسين علي

سرطان الثدي عند النساء العراقيات من نوع HER2 +VE مع الفائدة من استخدام العقار المناعي Trastuzumzb بعد الانتكاسه السريريه لاستخدامه Her2 positive Iraqi breast cancer women Use of trastuzumab beyond progression

المستخلص: Background : Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women. Her 2 positive disease carries worse prognosis and anti her 2 therapy is required in addition to chemotherapy which increase the cost of management of those patients especially in metastatic settingObjectives : The aim of this study to assess Iraqi breast cancer patients with HER2/neu molecular profile. Evaluate the role of using Trastuzumab in metastatic HER2/neu positive breast cancer patients beyond progression after its use in first line by changing the chemotherapeutic agent only.Patients & Methods : This is a retrospective study which was conducted in oncology teaching hospital - medical City complex from 1st of July 2017 to 1st of December 2017, carried out on 253 breast cancer female patients diagnosed within the period 2010 - 2017 with different age groups. Their histopathological reports, immunohistochemistry (IHC) results including ER, PR, HER2/neu and CISH test when indicated in addition to their clinical profile were collected. The subgroup of patients (253) with her2 positive disease were identified. From which patients with metastatic disease were analyzed for the use of trastuzumab beyond progression.Results : The mean age ± SD was (51.7 ± 11.1) years in HER2/neu positive patients, while it was (51.4 ± 13.8) in metastatic HER2/neu patients. The prevalence of HER2/neu positive 16.656 %( 95% CI : 16.468_16.843%). The mean of number of trastuzumab cycles used in patient that not metastatic HER2/neu was (16.6 ±3.9) and at metastatic HER2/neu was (16.1 ± 6.9). Median time to progression was 16 (95% CI : 11.009 - 20.991) months, after 6 months 92.8% had progression - free and after 12 month 53.8% had progression - free.Conclusion : HER2/neu positive disease constitutes 16.656% of Iraqi patients with breast cancer. And the median age for metastasis was (51.4 ± 13.8).Also Trastuzumab use beyond progression had a clinically significant metastatic free survival benefit. The cumulative incidence of metastasis to different body organs was lung (89.8%), liver (57.6%), and bone (45.8%), brain (27.8%).
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الاشعة العلاجية
السنة: 2018
الموضوع العام: الطب
اسم المشرف: منور عبد الاله النقاش
اسم المؤلف: وليد جاسم محمد

احداث الشريان التاجي بعد عام واحد من اعادة التوعية تجربة مركز واحدة Coronary artery events one year after revascularization : a single center experience

المستخلص: associated with concerns about their potential adverse effects. In - stent restenosis and stent thrombosis definitely affect the PCI outcome. However, review of recent relevant studies suggests that stent - related problems may have been somewhat overestimated when compared to coronary artery disease (CAD) progression at non stented coronary segments as causative factors of adverse cardiac clinical events late post - PCI.Both stent - related problems and native CAD progression have to be equally addressed to optimize the PCI clinical benefitAim of the study : To study the major adverse cardiac events and one year outcome after PCI.Patients & Methods : This study is cross - sectional study of all patients who were referred to Iraqi Center for heart disease, for further evaluation of suspected coronary artery disease (CAD) for the period January to July 2018. The total number of patients was fifty (50).Results : The total No. of patients were 50, mean age was 59.1±11.3, (22%) were below age 45 and (78%) equal and above age 45 year.54% were male and (46%) were female. The frequency risk factors were DM (62%), HT (56%), Dyslipidemias (52%), Obesity (21%) and Smoking (21%). The most common clinical presentations were chronic stable angina (98%) of cases and one case (2%) acute coronary syndrome. The outcome of PCI after one year divided in to four groups, group A : patients with ISR (5/50) (10 %), group B : patients with new stenosis (8/50) (16 %),group C : patients combined lesions (16/50) (32%) and group D (21/50) (42%) cases were normal.Conclusion : After one year from PCI there was high frequency of recurrence of symptoms exceeding half of the patients, most of them due to development of new lesion.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الامراض - القلب
السنة: 2018
الموضوع العام: الطب
اسم المشرف: حسن يوسف النجار
اسم المؤلف: مروان كامل عبود

مستوى فيتامين د والكالسيوم في مصل الدم لدى النساء الحوامل اللواتي يعانين من القئ المفرط الحملي في مستشفى بغداد التعليمي Serum Vitamin D and Calcium levels in Pregnant Women with Hyperemesis Gravidarum at Baghdad Teaching Hospital

المستخلص: الخلفية : نقص فيتامين (د) ومستوى الكالسيوم في الدم له علاقة مع القيء المفرط الحملي. كان هدف الدراسة الحالي هو فحص مستويات فيتامين د والكالسيوم في مصل الدم لدى النساء الحوامل المصابات بالقيء المفرط الحملي وتاثيراته على صحة الانجاب لدى النساء الحوامل.طريقة البحث : هذه دراسة مقطعيه تشمل 97 مشاركة تشمل النساء الحوامل المصابات بالقيء المفرط الحملي تمت في مدينة الطب / بغداد / العراق. تم جمع البيانات من قبل الباحث بعد اعداد استبيان منظم لهذا الغرض بعد الحصول على الموافقة اللفظية من قبل المشمولين بالدراسة (عمر الامهات، الاقامة، الحالات الزوجية، الاقتصادية والاجتماعية، والتعليمية والمهنية، التاريخ الحملي السابق والحالي ومؤشر كتلة الجسم). اجريت التحاليل المختبرية بحساب نسبة فيتامين د والكالسيوم في مصل الدم.النتائج : ان اعمار النساء المشاركات بهذه الدراسة كان يتراوح بين 16 الى 41 عام، حيث ان 70% من المشاركات في هذه الدراسة كان متوسط اعمارهم يتراوح بين 25 الى 35 عام. ان اغلب المشاركات كانوا من متوسطي الدخل المعاشي (40%)، مستوى تعليم متوسط (54%)، ربات البيوت (77%) ونساء متعددات الولادات (1 الى 3 ولادات) (47%). حسب منظمة الصحة العالمية ان معدل الاسقاطات بين النساء للحوامل يمثل نسبة عالية تصل الى (25%) والنساء اللاتي يلدن ولادات ميتة ايضا يشكل نسبة مرتفعة (12%). كان مؤشر كتلة الجسم 56 ٪ من عينة الدراسة. فيما يتعلق بفقر الدم، كان معظم عينات الدراسة يعانين من فقر الدم (70 ٪) مع التاريخ الغذائي السيئ اثناء الحمل (61 ٪) وانخفاض التعرض للشمس (84 ٪). وجود فقر الدم (فيتامين د : ص = 1.0؛ الكالسيوم : ر = 1.0) والتاريخ الغذائي (فيتامين د : ص = 0.07، ع = 0.82؛ كالسيوم : ر = 1.0) اثناء الحمل، كان له ارتباط عالي غير مهم للانقسام من النساء مع نقص فيتامين (د) وانخفاض الكالسيوم في الدم.الاستنتاج : توصلت الدراسة الى ان نسبة عالية من النساء الحوامل اللواتي يعانين من القيء المفرط الحملي تعاني من نقص في فيتامين د ومستوى الكالسيوم في مصل الدم، وكشفت ايضا ان الامهات التي يعنين من نقص فيتامين د ومستوى الكالسيوم في مصل الدم اثناء الحمل واللواتي يعانين من القيء المفرط الحملي يرتبطان ارتباطا بشكل كبير مع ارتفاع خطر الاصابة بفقر الدم. ان خطر نقص في فيتامين د ومستوى الكالسيوم في مصل الدم النساء الحوامل اللواتي يعانين من القيء المفرط الحملي ارتفاع في النساء الحوامل اللواتي كن ربات البيوت وذوي الحالة الاجتماعية والاقتصادية المنخفضة وكذلك الاقل تعرض لاشعة الشمس، ومعدومة النشاط البدني، وكمية اقل من تناول المكملات التي تحتوي على فيتامين د ومكملات الكالسيوم | Background : Vitamin’D’deficiency has a close relation with hyperemesis’gravidarum and serum’calcium level.The current study objective was’to investigate the levels of vitamin D’and serum calcium in pregnant women’with hyperemesis gravedarum and their’effects on their obstetric health. Methodology : This is a’cross - sectional study including 97’pregnant woman with hyperemesis’gravedarum’conducted in’Baghdad Teaching Hospital from the period of seven month starting from November 2017 to May 2018. Data collection from direct interview for the pregnant women.The sociodemographic’data was collected by researcher following a’structured questionnaire about (maternal age, residency, marital, economic and social states, educational and occupation states, previous and current obstetrical history and body mass index were collected). Laboratory Investigations were’done to’estimation of vitamin D and serum calcium level. Results : The age of women included in the study ranged from 16 to 41 years and 70% of them were between 25 and 35 years. Most of the participants were medium socioeconomic state (40%), secondary educational level (54%), homemakers (77%), and multipara (1 - 3 para) (47%). History of miscarriage among pregnant females (23%) and history of fetal death was (12%). Body Mass Index was 56% of study sampl, which are obese women. Regarding the anemia, most of study sampl was anemic (70%) with bad dietary history during pregnancy (61%) and low sun exposure (84%). The presence of anemia (vitamin D : r=1.0; calcium : r=1.0) and dietary history (vitamin D : r=0.07, p= 0.82; calcium : r=1.0) during pregnancy, had non - significant high correlation to division of women with deficient Vitamin D and low serum calcium. Conclusion : The study findings that high percentage in pregnant women with Hyperemesis Gravidarum has deficiency in serum vitamin D and calcium level also revealed that’maternal vitamin D deficiency’and low serum calcium in pregnant women with Hyperemesis Gravedarum are’significantly associated with elevated’risk for anemia. The risk of’vitamin D deficiency and low’serum calcium was higher Hyperemesis Gravedarum pregnant women which were’housewives, and those with low’socioeconomic state and less exposure to’sunlight, no physical activity, and less’vitamin D and calcium supplement intake.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: طب المجتمع
السنة: 2018
الموضوع العام: الطب
اسم المشرف: علياء مكي حسن الصافي
اسم المؤلف: نور جليل جبار الصائغ

تقويم معدل الاستنبات ومستوى السايتوكينات في المريضات المصابات بالعقم الغير مفسر بعد الخضوع لخدش بطانة الرحم Evaluation of Implantation Rate and Cytokines Level of unexplained Infertile Patients Undergoing Induced Endometrial Scratching

المستخلص: العقم مشكلة عالمية تؤثر على الملايين من الازواج ،ان اقرب تعريف للعقم هو مرض يصيب الجهاز التناسلي ويؤدي الى الفشل في تحقيق الحمل السريري بعد مرور12 شهرا او اكثر من الجماع الجنسي غير المحمي.وقد اقترحت العديد من الدراسات وجود تاثير ايجابي في خدش بطانة الرحم المقصودة على معدل نجاح انغراس البيضة المخصبة، وخاصة في النساء اللاتي عانوا فشل متكرر او اجهاض متكرر او العقم بدون اسباب مبررة. احداث خدش في بطانة الرحم يعزز رد فعل التهابي وهو مفيد لتفضيل زرع الجنين. يتم تجنيد الخلايا القاتلة الطبيعية والبلاعم والخلايا الشجيرية في الموقع المصاب وكميات متزايدة من السايتوكينات وعوامل النمو والجاذبات الكيمياوية، مثل عامل النخر (TNF - α) وinterleukin - 6 (IL - 6) ، مما يعزز غرس ناجح.صممت الدراسة لتقصي تاثير خدش بطانة الرحم على افراز المصل والبطانة من TNF - α وIL - 6 ، وتاثيره على تعزيز عملية الزرع الناجحة. اجريت الدراسة في مستشفى العلوية التعليمي ومركزمتخصص لعلاج العقم في بغداد. سجلت هذه الدراسة مريضات يعانون من عقم غير مفسر لاكثر من سنة وبعمر اقل من 45 عاما. تم اجراء دراسة هرمونية اساسية ، وتم تقسيم عينة الدراسة كما هو محدد الى ثلاث مجموعات ، 31 (29.5 ٪) على الجماع العفوي الطبيعي ، 31 (29.5 ٪) للتلقيح داخل الرحم (IUI) و43 (41.0 ٪) للتخصيب الاصطناعي) الاخصاب خارج الجسم اوطفل الانبوب) ثم تعريض جميع المريضات الى خدش بطانة الرحم في اليوم 8 من الدورة الشهرية (الدورة التي سبقت دورة الاخصاب خارج الجسم اوطفل الانبوب في مجموعة الاخصاب الاصطناعي او طفل الانبوب) ، عن طريق استخدام الناظور الرحمي ، تم قياس TNF - α وIL - 6 في افرازات المصل والبطانة قبل وبعد الخدش.كانت معدلات الحمل 22 (33.33 ٪) ، 20 (30.30 ٪) ، و24 (36.4 ٪) عن مجموعة الجماع العفوي الطبيعي ، التلقيح داخل الرحم ، والتخصيب الاصطناعي، على التوالي ، وكانت حسابات الاختطار النسبي للحمل اعلى للمجموعة العفوية مع 1.194 RR ، 95٪ CI (0.892 - 1.1601) ، تليها مجموعة التلقيح داخل الرحم مع RR 1.038 ، 95٪ CI (0.757 - 1.423) ، وادنى في مجموعة التلقيح داخل الرحم ، مع RR 0.824 ، وCI 95٪ (0.600 - 1.131).من خلال قياس اثنين من اهم السيتوكينات في افرازات المصل والبطانة من المرضى المشاركين في هذه الدراسة قبل وبعد خدش بطانة الرحم ، وجد انه كان هناك فرق ذو دلالة احصائية (قيمة p <0.001) في TNF المصل والبطانة لانها كانت 3.84 ± 2.41 بيكوغرام / ديسيلتر ، و3.81 ± 2.30 بيكوغرام / ديسيلتر ، على التوالي ، وارتفعت الى 17.35 ± 6.39 بيكوغرام / ديسيلتر في المصل و22.84 ± 9.67 بيكوغرام / ديسيلتر في افرازات بطانة الرحم بعد خدش. كما اظهر IL6 اختلافا معنويا في المصل وفي افرازات بطانة الرحم ، حيث بلغ متوسط مستويات المصل IL6 4.27 ± 2.18 بيكوغرام / ديسيلتر قبل الخدش وارتفع الى 16.46 ± 4.27 بيكوغرام / ديسيلتر بعد الخدش ، في حين كان IL6 في افراز بطانة الرحم 3.86 ± 2.42 بيكوغرام / ديسيلتر قبل الخدش وزيادة الى 22.35 ± 9.14 بيكوغرام / ديسيلتر بعد الخدش.كان تاثير خدش بطانة الرحم على مؤشر النبض ذو دلالة احصائية مع فارق متوسط 0.893 ± 0.393 حيث كان 3.584 ± 0.373 قبل الخدش وانخفض الى 2.690 ± 0.357 بعد الخدش ، مع تغير متوسط النسبة بنسبة 24.54٪ ± 9.95٪.كانت هناك علاقة ارتباط معتدلة ذات دلالة احصائية مهمة بين تطور الحمل وارتفاع مستوى المصل والـ TNF ، وكانت اعلى في افرازات بطانة الرحم من TNF المصل ، ولكن بالنسبة لـ IL6 لم يكن هناك سوى علاقة ضعيفة ذات دلالة احصائية بين بطانة الرحم IL6 والحمل.وخلصت هذه الدراسة الى ان خدش بطانة الرحم يزيد معدل الحمل في جميع مجموعات الدراسة ولكن الحمل العفوي اكثر من التلقيح داخل الرحم، والاخير اكثر من التخصيب الاصطناعي. يسبب خدش بطانة الرحم زيادة كبيرة في تركيزات المصل وافرازات البطانة من TNF - α وIL - 6. وارتبط ارتفاع مستويات TNF - α وIL - 6 مع نتائج حمل افضل. ان خدش بطانة الرحم يقلل من معدل مؤشر المقاومة الشريانية للشريان الرحمي الذي يعني معدل تدفق افضل للدم وبالتالي تحسين نتيجة الحمل. | Infertility is a worldwide problem, affecting millions of couples, and never an old subject. Infertility is “a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Several studies have suggested a favorable effect of endometrial injury on the implantation success rate, especially in women with recurrent implantation failure or recurrent abortion or unexplained infertility. When local injury - induced in endometrial tissue this enhance an inflammatory reaction which is useful for favors implantation of embryo. Natural killer cells, macrophages, and dendritic cells are recruited to the injured site and increased quantities of cytokines, growth factors, and chemokines like Tumor necrosis factor - alpha, and interleukin - 6, all are secreted, thus resulting in a successful implantation. This prospective interventional study was designed to evaluate the effect of endometrial scratch on serum and endometrial secretion of Tumor necrosis factor - alpha and interleukin - 6, and its effect on promoting successful implantation. The study was done in Al - Alwia Teaching Hospital and privet infertility treatment center in Baghdad from January 2016 till December 2017. This study enrolled 105 female patients with unexplained infertility for more than 1 year and with age under 45 years. Basic hormonal study was done, and study sample was divided as indicated into three groups, 31 (29.5%) for natural conception, 31 (29.5%) for intrauterine insemination and 43 (41.0%) for in vitro fertilization program ,then all patients undergone endometrial scratch, at day 8 of menstrual cycle (in in vitro fertilization program group the scratch of endometrium done in the cycle that preceded the in vitro fertilization procedure ), by using hysteroscopy. Tumor necrosis factor - alpha, and interleukin - 6 was measured in serum and endometrial secretions before and after scratch. pregnancy rates for three groups was 22 (33.33%), 20 (30.30%), and 24 (36.4%) for Natural, Intra Uterine Insemination and In Vitro Fertilization , respectively and when calculate the relative risk (beneficial risk) for pregnancy it reveal that the highest for Natural conception group with 1.194 RR, 95% confidence interval (0.892 - 1.1601), followed by Intra Uterine Insemination group with RR of 1.038, 95% confidence interval (0.757 - 1.423), and lowest in In Vitro Fertilization group, with RR of 0.824, and 95% confidence interval (0.600 - 1.131). By measuring two of the most important cytokines in serum and endometrial secretions of patients involved in this study both before and after endometrial scratch, it was found that there was a highly significant difference (p - value <0.001) in serum and endometrial Tumor necrosis factor - alpha, as were 3.84 ± 2.41 pg/dl, and 3.81 ±2.30 pg/dl, respectively, and increased to 17.35 ±6.39 pg/dl in serum and 22.84 ±9.67 pg/dl in endometrial secretions after scratch. Also interleukin - 6 showed highly significant difference in serum and in endometrial secretions, as the mean serum levels of IL6 was 4.27 ±2.18 pg/dl before scratch and increased to 16.46 ±4.27 pg/dl after scratch, while the interleukin - 6 in endometrial secretion was 3.86 ±2.42 pg/dl before scratch and increased to 22.35 ± 9.14 pg/dl after scratch. The effect of endometrial scratch on pulsatility index was statistically significant with a mean difference of 0.893 ±0.393 as it was 3.584 ± 0.373 before scratch and decreased to 2.690 ± 0.357 after scratch, with mean percent change of 24.54% ± 9.95% reduction. There was a moderate statistically significant positive correlation between developing pregnancy and higher serum and endometrial Tumor necrosis factor - alpha, and that it was higher in endometrial secretions than serum Tumor necrosis factor - alpha , but for interleukin - 6 there was only a weak statistically significant correlation between endometrial interleukin - 6 and pregnancy. This study concluded that endometrial scratch increase pregnancy rate in all study groups but Natural conception is more than Intra Uterine Insemination and Intra Uterine Insemination is more than In vitro Fertilization - Embryo Transfer. Endometrial scratch causes a significant increment in serum and endometrial concentration of Tumor necrosis factor - alpha and IL - 6. Higher levels of Tumor necrosis factor - alpha and interleukin - 6 were associated with better pregnancy outcomes. Endometrial scratch decrease pulsatility index which mean better blood flow rate and good pregnancy outcome.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
الموضوع الدقيق: النسائية والتوليد
السنة: 2018
الموضوع العام: الطب
اسم المشرف: عفان عزت حسن الفت محمد علي النقاش
اسم المؤلف: ايمان حسن فليح

مجموعة التباين الوراثي احادي القاعدة للتلومريز, XPC وXRCC7 المتغيرة جينيا في المرضى المدخنين العراقيين المصابين بورم المثانة Single Nucleotide Polymorphism (SNP) Panel for Telomerase, XPC, and XRCC7 Genes Variants in Iraqi Smoker Patients with Bladder Tumor

المستخلص: سرطان المثانة هو واحد من اكثر الاورام الخبيثة شيوعا في المسالك البولية. يعتبر استهلاك التبغ لفترات طويلة احد العوامل الرئيسية المسببة لتطور سرطان المثانة ، والتي تسبب تلف الحمض النووي. ولذلك ، فان مسار اصلاح الحمض النووي هو من اهم النظم التي تحافظ على سلامة الجينات ومنع التسرطن. وكان الهدف من هذه الدراسة هو معرفة تاثير التباين الوراثي احادي القاعدة لثلاثة جينات مسؤولة عن اصلاح الحمض النووي TEP1 / rs2228041 , XPC / rs2228000) و( XRCC7 7003908 على الخطر بالاصابة بهذا المرض.الاهداف : ان الهدف الرئيسي من هذه الدراسة هو محاولة ايجاد علاقة بين التباين الوراثي احادي القاعدة الموجودة في ثلاثة جينات مختلفة مسؤولة عن اصلاح الحمض النووي والتحقق من تاثير تدخين التبغ على التباين الوراثي الموجود في جنات اصلاح الحمض النووي البشري TEP1 / rs2228041 ) ، XPC / rs2228000 و(XRCC7 7003908 في المرضى الذين يعانون من سرطان المثانة في وتاثيرها على تطور ومرحلة المرض.المرضى وطرق العمل : اشتملت هذه الدراسة على مجموع من 62 مريض مشخص بسرطان المثانة و38 شخص من الاصحاء مطابقين لهم بالعمر والجنس. تم جمع هذه العينات في الفترة من فبراير الى سبتمبر لسنة 2017 في دراسة مقارنة لمجموعه المرضى والاصحاء التي اجريت في قسم الكيمياء الحيوية في كلية الطب بجامعة بغداد.تم الكشف عن النمط الجيني لل TEP1 / rs2228041 (C> T) وXPC rs2228000 (C> T) باستخدام تفاعل البلمرة المتسلسل وطريقة سانجر في ايجاد تسلسل الحمض النووي.بينما كشف عن النمط الجيني للتباين الوراثي XRCC7 (T> G) باستخدام تفاعل البلمرة المتسلسل والمتحدد بطول القطعة المتباينة الشكل, (PCR - RFLP) وتاكيده تسلسل الحمض النووي باستخدام طريقة سانجر. تم حساب نسبة الارجحية (OR) ومجال الثقة 95 ٪ (CI) كمقياس للتاثير المشترك للتدخين السجائر ، والجينات اصلاح الحمض النووي المتباينة الشكل على خطر الاصابة بسرطان المثانة وتطوره ومراحلهه.النتائج : في هذه الدراسة ، اظهر الاليل T المتباين الشكل للجين TEP1 rs222804 علاقة معنوية في زيادة خطر الاصابة بسرطان المثانة (OR = 4.7, *p=0.04). ايضا ، اظهر الاليل T وجود علاقة معنوية في زيادة خطر الاصابة بسرطان المثانة بين الافراد المدخنين (OR =7.02, *p=0.01)علاوة على ذلك ، اظهر الاليل T علاقة معنوية لمرحلة T2 لسرطان المثانة ((OR=13.2, **p=0.001 اظهر النمط الوراثي المغاير الزيجة من XPC rs2228000 (C> T) زيادة كبيرة في خطر الاصابة بسرطان المثانة (OR=2.75, *p value<0.05). كذلك ، قد وجدت الدراسة ان المرضى الذين يعانون من الاليل متعدد الاشكال للنمط الجيني T قد زاد بشكل كبير من خطر الاصابة بسرطان المثانة (OR= 2.7; *p = 0.02).احصائيا, وجدت زيادة معنوية كبيرة في خطر الاصابة بسرطان المثانة عند الاشخاص المدخنين الحاملين للاليل T (OR= 4.3; **p = 0.004).علاوة على ذلك ، لوحظ ايضا ان الطرز الوراثية للاليل T ترتبط بزيادة ملحوظة في خطر T1 (OR= 3.9 **p = 0.005).في الدراسة الحالية ,ان خطر الاصابة بسرطان المثانة قد ازداد بشكل كبير لدى الاشخاص الحاملين للجين متعدد الاشكال متماثل الزيجة الوراثية (للنمط الجيني GG) (OR= 4.0; *p = 0.03) في حين ان النسبة بهذا الخطر قد قلت لدى الاشخاص الذين لديهم جين من النوع الطبيعي (للنمط الجيني TT). ايضا ، زيادة خطر الاصابة بسرطان المثانة زيادة كبيرة احصائيا بين الافراد الحاملين للاليل G(OR= 5.5; ***p = 0.0001). كما لوحظ ان النمط الوراثي للاليل G مرتبط بزيادة كبيرة بخطر الاصابة بالمرحلة T2 لسرطان المثانة (OR= 3.7; **p = 0.001) ، وايضا Ta (OR= 3.5; **p = 0.003).استنتاجتوحي الدراسة الحالية ان وجود الانماط الجينية المتباينة الاشكال لجينات اصلاح الحمض النووري للمروثات يمكن ان يزيد من خطر الاصابة بسرطان المثانة ويؤثر ايضا على تطور ومراحل المرض في حين ان النمط الجيني الطبيعي يمكن ان يقلل من خطر الاصابة بسرطان المثانة وزيادة معدل البقاء على قيد الحياة لمرضى سرطان المثانة. علاوة على ذلك ، يمكن لهذه الاشكال الجينية ان تكون اداة مفيدة لمعالجة المرض للافراد الذين لديهم مقاومة لعلاج السرطان. | XPC Xeroderma pigmentosum CXPG Xeroderma pigmentosum G AbstractBackgroundBladder cancer is one of the most common malignancies of the urinary tract. Prolonged tobacco consumption constitutes the major etiological factors for bladder cancer development, which induce DNA damage. Therefore, DNA repair pathway is a crucial system in maintaining genomic integrity and preventing carcinogenesis. The present work was aimed to predict the consequence of three polymorphisms of the DNA repair genes (TEP1/rs2228041, XPC/rs2228000, and XRCC7 7003908) on the disease predisposition.ObjectivesThe main objective of this study is attempted to find the association between SNPs in different DNA repair pathway and investigating the influence of active tobacco smoking on human DNA repair gene polymorphisms (TEP1/rs2228041, XPC/rs2228000 and XRCC7 7003908) in patients with bladder cancer in and the impact of these polymorphism on the staging and development of the disease.Subjects and MethodsA total of 62 of histo - pathologically confirmed diagnosed bladder cancer patients, and 38 age - matched healthy controls were involved in the study. All were recruited from February to September 2017 in a case - control study conducted at the Department of Biochemistry - College of Medicine University of Baghdad. Genotyping of the TEP1/rs2228041 (C>T) and XPC rs2228000 (C>T) was evaluated using polymerase chain reaction and fully genotyped by Sanger sequencing method. Genotyping of the XRCC7 polymorphism (T>G) was evaluated using a polymerase chain reaction - restricted fragment length polymorphism (PCR - RFLP) and confirmed by Sanger sequencing method. The odds ratio (OR) and 95% confidence interval (CI) were calculated as a measure of the combined effect of cigarette smoking, and DNA Repair Genes Polymorphisms on bladder cancer risk, staging.ResultsIn this study, the polymorphic T allele of the TEP1 rs222804 polymorphism showed a significant association in increase bladder cancer risk OR = 4.7, p=0.04. Also, the T allele showed a significant association in increase bladder cancer risk among smoker individuals OR= 7.02, p=0.01. Furthermore, the T allele showed a significant association for the T2 stage of bladder cancer (OR=13.2, p=0.001). Heterozygous genotype of the XPC rs2228000 (C>T) showed a significant increase in bladder cancer risk OR =2.75, p value<0.05. Also, the study found that patients with the polymorphic allele (T genotype) have significantly increased the risk of bladder cancer (OR= 2.7; p = 0.02). A statistically highly significant increased in bladder cancer risk was found in the smoker individuals who carrying T Allele (OR= 4.3; p = 0.004). Moreover, T Allele genotypes were also observed to be associated with a significantly increased risk of T1 (OR= 3.9; p = 0.005). In the current study, individuals with the homo polymorphic gene (GG genotype) have significantly increased the risk of bladder cancer (OR= 4.0; p = 0.03), while subjects having the homo wild - type gene (TT genotype) could decrease the risk of bladder cancer. Also, a statistically highly significant increased bladder cancer risk in the smoker individuals who carrying G Allele (OR= 5.5; p = 0.0001). G Allele genotypes were also observed to be associated with a significantly increased risk of T2 (OR= 3.7; p = 0.001), and for Ta (OR= 3.5; p = 0.003).ConclusionThe present study suggested that having polymorphic genotypes of DNA repair gene polymorphisms (TEP1/rs2228041, XPC/rs2228000 and XRCC7 7003908) could increase the risk of bladder cancer and also affect the development and staging of the disease while having the wild type genotypes could decrease the risk of bladder cancer and increase the survival rate of bladder cancer patients. Furthermore, these gene polymorphisms could be a useful tool to tackle these emerging problems and is an attractive target for individual anticancer treatment.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
السنة: 2019
الموضوع العام: الطب
اسم المشرف: هدف ظافر الياسين اسامة سليمان الناصري
اسم المؤلف: صالح علي محمود

اتجاه مرض التهاب السحايا للاطفال دون سن 51 عام في مستشفى حماية الطفل التعليمي ومستشفى الطفل المركزي التعليمي قبل وبعد ادخال اللقاح المستدمية النزلية نوع ب في البرنامج الوطني للقاح الاطفال من 2011 - الى 2014 Trend of Meningitis in children below 15 years old in Welfare Teaching children Hospital and Central Children Teaching Hospital before and after introduction of Haemophillus influenza type b vaccine From 2011 To 2014

المستخلص: Meningitis is serious threat to children health (esp. bacterial) particularly in developing countries. Early diagnosis and management may prevent children from death and serious complication ObjectivesTo determine type of meningitis and characteristic and outcome in children below 15 years old in a period before and after introduction of Haemophillus influenza type b (2011 - 2012 - 2013 - 2013(.Method A retrospective cross sectional study of children below 15 years old diagnosed with acute meningitis who were admitted to welfare children teaching hospital and central children teaching hospital in Baghdad for year : 2011 - 2012 - 2013 - 2014. Statistical analysis done by using SPSS version 23.ResultIn 290 patients, The mean age of children with meningitis was 32.46 month (2.6year). Bacterial meningitis was 25.2%, probable meningitis was 26.6%, and viral meningitis was 45.2%. The most frequent type of bacteria in 73 patient was streptococcal Pneumonia 47.9% followed by Neisseria meningitis 24.7% followed by E coli 9.6% then haemophillus influenza 6.8%. There was significant statistical association between type of meningitis with residence area. Case fatality rate was 4.8%, case fatality rate from bacterial meningitis was 10.9%, case fatality from streptococcal pneumonia was 11.4% and from Neisseria meningitis was 22.2%.Conclusion and recommendation Meningitis is more frequent in age below one year. Streptococcal pneumonia was the most frequent bacterial pathogen. The study recommend more study about misuse antibiotic.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: طب العائلة
السنة: 2018
الموضوع العام: الطب
اسم المشرف: نادية عزيز ناصر
اسم المؤلف: ميس حسن جاسب

مستوى الكالبروتيكتين بروتين (S - 100) في مصل الدم للمرضى المصابين بالتهاب الفقار المقسط في العراق وعلاقته بالعلاج, نشاط المرض وتنميط.HLA The Serum Level of Calprotectin (S - 100 protein) in Iraqi Patients with Ankylosing Spondylitis and its Relation with Treatment, Disease Activity and HLA Typing

المستخلص: لقد اجريت هذه الدراسة في الفترة ما بين تشرين الاول عام 2016 وتشرين الاول عام 2017 على 90 شخصا تم تشخيص 60 منهم على انهم مصابين بالتهاب الفقار المقسط (مجموعة المرضى) وكان 30 منهم يتناولون العلاج التقليدي (الستيرويد و/او العقاقير السامة للخلايا) الذين كانوا يحضرون للعيادة الخارجية للمفاصل بمستشفى بغداد التعليمي في حين كان هناك 30 مريضا اخرين يتلقون العلاج البيولوجي Inliximab infusion)) وهم يحضرون ردهة العلاج البيولوجي وكان هناك ايضا 30 اخرون من مجموعة الاصحاء. تم جمع عينات الدم من المرضى والاصحاء لتقييم الكالبروتيكتين(Calprotectin) (Matrix(metalloproteinase - 3) في مصل الدم وتم الكشف عنها بواسطة مقايسة الممتز المناعي المرتبط بالانزيم ELISA)). تم قياس hs - CRP بواسطة nephlometer كما تم فحص HLA B - 27 بواسطة التفاعل المتسلسل للبوليميريز في الوقت الحقيقي RT - PCR)). كان مجموع مرضى الدراسة الحالية 60 مريضا، كان متوسط اعمارهم 40.05 ± 8.02 سنة ، وكانت نسبة الذكور سائدة اكثر من الاناث في نسبة (M : F 11 : 1). لقد اوضحت الدراسة الحالية ان مستويات الكالبروتيكتين في المصل كانت اعلى في مجموعة المرضى (89.23 ± 73.97) من مجموعة الاصحاء (54.94 ± 20.51) وكان هذا الفرق ذو دلالة احصائية (P= 0.0148) ، وكان اعلى ايضا في المرضى الذين عولجوا بالعلاج التقليدي مقارنة بالمرضى الذين عولجوا بالعلاج البيولوجي (infliximab infusion) وكان الفرق ذو دلالة احصائية (P = 0.0013) بينما لم يكن هناك فرقا احصائيا بين المرضى الذين كان BASDAI وBASFI < 4.0 وغيرهم من المرضى الذين كان BASDAI و4.0 ≤ BASFI ولا بين المرضى الذين HLA B - 27 ايجابية وغيرها سلبية. لقد كان متوسط مستوى المصل من مركب Metalloproteinase - 3 من المرضى اعلى من مجموعة الاصحاء وكان ذو دلالة احصائية عالية (P= 0.0093)وكان اعلى ايضا في المرضى الذين عولجوا بالعلاج التقليدي ، مقارنة بالمرضى في العلاج البيولوجي (infliximab infusion) والفرق كان ذو دلالة احصائية (P value = 0.0235). وفيما يتعلق باختبار hs - CRP الذي كشف ان متوسط مستوى hs - CRP في المصل للمرضى كان اعلى من مجموعة الاصحاء وكان ذو دلالة احصائية عالية (P= 0.0001) وكان اعلى ايضا في المرضى الذين عولجوا بالعلاج التقليدي ، مقارنة بالمرضى الذين كانوا يتلقون العلاج البيولوجي (infliximab infusion) وكان هذا الفرق ذو دلالة احصائية(P = 0.0235). لقد اظهرت الدراسة الحالية ان HLA B - 27 كان ايجابيا في 34 مريضا (56.7 ٪) ، ولم يكن موجبا في اي شخص من مجموعة الاصحاء وكان هذا الفرق ذو دلالة احصائية عالية (P < 0.0001) وكان هناك فرق كبير من hs - CRP بين مجموعات HLA B - 27 الايجابية والسلبية (P= 0.0437) ولم يتم الكشف عن اختلافات اخرى (ESR ، Calprotectin ، MMP - 3 ، BASDAI ، BASFI) بين مجموعة المرضى HLA B - 27 الايجابية والسلبية. فيما يتعلق بالعلاقة بين ESR وCalprotectin وMMP - 3 وhs - CRP في كلا المجموعتين من المرضى. كان هناك ارتباط مباشر كبير بين hs - CRP وESR (P value = 0.005) ولم يلاحظ اي ارتباط بين المعلمات الاخرى في كلتا المجموعتين من المرضى.لقد اوضحت الدراسة ان الكالبروتيكتين في المصل كان اعلى في مجموعة المرضى من مجموعة الاصحاء وكان اعلى في المرضى الذين يتلقون العلاج التقليدي مقارنة بالمرضى المعالجين بالعلاج البيولوجي ولم تكن هناك علاقة بين مستوى الكالبروتيكتين في المصل ونشاط المرض ولا بوجود HLA B - 27 . | patients were diagnosed as established ankylosing spondylitis patients, thirty (30) patients of them were on conventional treatment (steroid and/or cytotoxic drugs) who were attending the Rheumatology Outpatient Clinic of Baghdad Teaching Hospital, while the other thirty (30) patients were on biological treatment (infliximab infusion) attending biological therapy room and other thirty (30) were apparently healthy control group. Blood samples were collected from patients and controls to assess Serum calprotectin and matrix metalloproteinase - 3 which were detected by enzyme linked immunosorbent assay, the high sensitivity C - Reactive Protein was measured by nephelometer,, wherease Human Leucocyte Antigen B - 27 has been done by real time polymerase chain reaction. Out of 60 patients study group included in the current study, their mean age was 40.05 ± 8.02 years, the males were predominant than females in a ratio (M : F 11 : 1). The current study revealed that serum level of calprotectin is higher in patient group (89.23±73.97) than control group (54.94±20.51) and this difference is statistically significant (P - value =0.0148), and also is higher in patients treated with conventional treatment, than in patients treated with biological treatment (infliximab infusion) and the difference is statistically significant (P - value =0.0013) while the difference is not statistically significant between patients whose Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index < 4.0 and other patients whose Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index ≥ 4.0 nor between patients whose Human Leucocyte Antigen B - 27 positive and others negative. Mean serum level of matrix metalloproteinase - 3 of patients is higher than control group and is highly statistically significant (P - Value 0.0093) and also higher in patients treated with conventional treatment, than in patients on biological treatment (infliximab infusion) and the difference is statistically significant (P - value =0.0235). Regarding high sensitivity C - Reactive Protein test which revealed that mean serum level of high sensitivity C - Reactive Protein of patient higher than control group and is highly statistically significant (P - Value =0.0001) and also higher in patients treated with conventional treatment, than in patients on biological treatment (infliximab infusion) and this difference is statistically significant (P - value = 0.0235). The current study showed that Human Leucocyte Antigen B - 27 was positive in 34 (56.7 %) patients, and in no subject ( 0 %) from control group and this difference is highly statistically significant (P - Value < 0.0001) and there is a significant difference of high sensitivity C - Reactive Protein between positive and negative Human Leucocyte Antigen B - 27 groups (P - value =0.0437) and no other differences detected of (Erythrocyte Sedimentation Rate, Calprotectin, matrix metalloproteinase - 3, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index) between positive and negative Human Leucocyte Antigen B - 27 patients group. Regarding the correlation between Erythrocyte Sedimentation Rate, Calprotectin, matrix metalloproteinase - 3 and high sensitivity C - Reactive Protein in both patients groups; there is a significant direct correlation between high sensitivity C - Reactive Protein and Erythrocyte Sedimentation Rate (P - value=0.005) and no correlation is observed between the other parameters in both patients groups. The study had showed that serum Calprotectin is higher in patients group than control group and also higher in patients on conventional treatment than in patients on biological treatment, and there is no relation between serum calprotectin level and disease activity nor Human Leucocyte Antigen B - 27 typing
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
السنة: 2018
الموضوع العام: الطب
اسم المشرف: جاسم محمد كرحوت محمد هادي العصامي
اسم المؤلف: خالد محمد عبد الواحد

تقييم وظائف البطين الايمن لمرضى العيب الاذيني للقلب قبل وبعد القسطرة العلاجية بواسطة تتبع ضربات القلب Evaluation of RV functions in ASD patients pre & post transcatheter occlusion by speckle tracking

المستخلص: Background : The atrial septal defect is a common congenital heart disease. Speckle tracking echocardiography is non - invasive diagnostic technique used in assessment of myocardial function. Aim of study : To evaluate the feasibility and reproducibility of right ventricular 2D Strain assessed by speckle tracking in patients undergoing atrial septal defect transcatheter occlusion compared with conventional markers before and after transcatheter occlusion.Patients and methods : A prospective follow up study conducted in Ibn AL - Bitar Specialized Center for Cardiac Surgery in Baghdad during the period from 1st of July, 2017 to 30th of June, 2018 on sample of 30 patients with atrial septal defect and sample of 30 healthy controls. All patients were investigated with echocardiography and speckle tracking one month before transcatheter occlusion and one month after the transcatheter occlusion.Results : Post transcatheter occlusion, there was a significant decrease in mean right ventricular end diastolic dimension (p<0.001) and a significant decrease in mean of tricuspid annular plain systolic excursion (p<0.001). There was a significant increase in global strain speckle tracking echocardiography mean post transcatheter occlusion (p<0.001). The global strain speckle tracking echocardiography mean was significantly higher among controls and atrial septal defect patients in post occlusion while lower among patients in pre - occlusion (p<0.001) with no significant difference in global strain mean between controls and patients in post occlusion (p=0.1). Conclusions : The speckle tracking echocardiography is a valuable diagnostic technique for evaluation of right ventricular function before and after transcatheter occlusion of atrial septal defect in adults
الصفحات الاولى:
الكلمات الدلالية:
  • Atrial septal defect
  • Speckle tracking defect
  • Right ventricular function
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الامراض - القلب
السنة: 2018
الموضوع العام: الطب
اسم المشرف: علاء عبد الحسين الانباري
اسم المؤلف: فينوس عبد الواحد علوان

قياس الفعالية الانزيمية وتحديد الطفرات الجينية لانزيم الثايوبيورين الناقل لمجموع المثيل في عينة من الاطفال العراقيين المصابين بسرطان الدم اللمفاوي الحاد Thiopurine S - Methyltransferase Phenotype and Genotype in a Sample of Iraqi Children with Acute Lymphoblastic Leukemia

المستخلص: Background : The most common childhood cancer is acute lymphoblastic leukemia which is only treated with chemotherapy alone.All modern protocols of acute lymphoblastic leukemia treatment used thiopurine drugs as an essential anti - cancer drug which used for a long period of time. The 6 - Mercaptopurine is an anti - cancer drug widely used for treating acute lymphoblastic leukemia patients. The patients with low Thiopurine S - Methyltransferase enzyme activity is with an increased risk of developing drug toxicity and consequently unsuccessful acute lymphoblastic leukemia outcome and even death.Thiopurine S - Methyltransferase is one of the main enzymes involved in 6 - mercaptopurine metabolism, and the low activity of this enzyme is strongly correlated to the Thiopurine S - Methyltransferase genetic polymorphism.Aim : Find out the three most common Thiopurine S - Methyltransferase enzyme polymorphism TPMT*3A, TPMT*3B and TPMT*3C in Iraqi pediatric patients with acute lymphoblastic leukemia, and its frequencies. Analyses of Thiopurine S - Methyltransferase activity in the serum of those patients, and compare the results with other population. Methods : This is a cross - sectional study included eighty - one (81) Iraqi pediatric patients with acute lymphoblastic leukemia during the maintenance phase of their UKALL protocol treatment, receiving 6 - Mercaptopurine drug with age range from 1.83 (1year and 10 months) to 16.25 (16 years and 3 months). Thiopurine S - Methyltransferase activity was measured in the patients’ serum by Enzyme - Linked Immunosorbent Assay technique and three of Thiopurine SMethyltransferase genetic polymorphisms were detected by allelespecific multiplex - PCR analysis after DNA extraction from the whole blood. Liver Function Tests were measured by calorimetric method; Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase and Total Serum Bilirubin in addition to Complete BloodCount measured by automated hematology system. Results : There was significant difference in the mean of Thiopurine S - Methyltransferase activity between pediatric patients carrying the wild - type allele TPMT*1 (n=49), with allele frequencies of 60.4% and pediatric patients (n=32) carrying the mutant alleles (TPMT*3A or TPMT*3C) with allele frequencies of 81.2% and 18.7% respectively. The TPMT*3B allele was not detected in this group. The P - value was highly significant (P<0.000**).Conclusion : This study is the first to analyze Thiopurine SMethyltransferase mutant gene frequency in a sample of the Iraqi population, and it revealed the presence of TPMT*3A and TPMT*3C genetic polymorphism but not a TPMT*3B mutant allele. Thiopurine S - Methyltransferase activity was low in the patients with mutant gene as compared with the wild - type allele patients. Finally, genotype and phenotype of Thiopurine S - Methyltransferase enzyme is an essential predictor to reduce the cytotoxic effects of the anticancer drug and successful acute lymphoblastic leukemia treatment.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
السنة: 2018
الموضوع العام: الطب
اسم المشرف: منال كمال رشيد حسنين حبيب غالي
اسم المؤلف: نوار سمير محمد

تركيزات البلازما والاداة المساعدة للتشخيص لعامل النمو البطاني الوعائي (VEGF) ، مصفوفة ميتالوبروتيناز - 2 (MMP - 2) ، مثبطات الانسجة لمركب الميتالوبروتيناز - 2 (TIMP - 2) والمستعمرة الضخمة (M - CSF) في النساء اللواتي يعانين من ورم الثدي : دراسة مقارنة مع م Plasma Concentrations and Diagnostic Utility of Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinase - 2 (MMP - 2), Tissue Inhibitors of Metalloproteinase - 2 (TIMP - 2), and Macrophage Colony Stimulating Factor (M - CSF) in Women with Brea

المستخلص: سرطان الثدي هو الورم الخبيث الاكثر شيوعا في النساءويعتبرالسبب الرئيسي الثاني لوفاة مرضى السرطان في العالم. تعتبر الوقاية والكشف المبكر هوالطريقة الاكثر فعالية لمكافحة السرطان. خلال العقد الماضي ، جذبت الكثير من علامات البيوكيميائية لسرطان الثدي انتباه العديد من الباحثين. هذه العلامات يمكن استخدامها في مراقبة العلاج ، والتنبؤ بدرجة اصابة الانسجة ، وسلوك الورم ، ومدى انتشاره ، واحتمالية اصابةالعقد الليمفاوية. من بين هذه الواصمات الحيوية ، عامل نمو بطانة الاوعية الدموية (VEGF) ، خلايا البلعوم المحفزة للحفظ (M - CSF)، ومصفوفة الميتالوبروتنيز MMP - 2))، ومثبطات الانسجة لمركب الميتالوبروتينيز(TIMP - 2). تشير الدلائل المتزايدة الى ان قياس VEGF هو افضل مرشح لتشخيص سرطان الثدي (افضل من مستضد السرطانCA 15 - 3 ) خاصة في المرحلتين الاولى والثانية وكذلك في التمايز بين الورم الخبيث وورم الثدي الحميد. اظهرت الدراسات ان قياس VEGF لا سيما مع CA 15 - 3 ، اعلى فائدة وقوة تشخيصية في الكشف عن سرطان الثدي.وفي الاونة الاخيرة ، تم التوصل في البحوث الحديثة الى ان TIMP - 2 قد يكون ذو فائدة في التشخيص المبكر لسرطان الثدي في مراحله الاولى زتهدف هذه الدراسة الى : 1) قياس تركيزات البلازما لبعض المرقمات الحيوية الجديدة بما في ذلك : عامل نمو بطانة الاوعية الدموية (VEGF) ، ومصفوفة الميتالوبروتينيز ((MMP - 2 ، ومثبط الانسجة لمركب الميتالوبروتينيز ((TIMP - 2 ، وعامل تحفيز مستعمرة البلعم (M - CSF) بالاضافة الى مثبط السرطان 15 - 3 ( CA15 - 3) في النساء المرضى الذين يعانون من ورم الثدي بالمقارنة مع النساء الاصحاء.2) التحقيق في الاداة التشخيصية لكل من المرقم الحيوي المقاس (وبالاقتران مع بعضها البعض) في الكشف عن ورم الثدي و(3) مقارنة النتائج مع معلمات الهستوباثولوجي ( العمر, الجنس , الحالة الزوجية , سن الياس حجم الورم , مرحلة الورم السرطاني , مستقبل الاستروجين , مستقبل الروجيستيرون ومستقبلات 2 Her)المواد وطرق العمل : اشتملت الدراسة على 88 امراة عراقية تم تقسيمهم الى ثلاثة مجاميع : 38 امراة مصابة بسرطان الثدي (Group I, BC) ، 25 امراة مصابات بورم الثدي الحميد الغدي الليفي Fibroadenoma (FA) (Group II, FA benign ) اللواتي تم تشخيصهن من قبل مجموعة اخصائي الاورام و25 امراة سليمة (كمجموعة ضابطة). تم تشخيص ورم الثدي من قبل مجموعة من الاخصائيين في الاورام. حيث تم التشخيص بناء فحوصات تجرى على عينة تؤخذ من خزعة نسيجية من ورم الثدي او بعد استئصال الثدي. تم تنفيذ اجراءات التدريج العلاجي على اساس فحوصات الجسم والدم ، والتصوير الشعاعي للثدي ، وفحص الثدي بالموجات فوق الصوتية ، والاشعة السينية للصدر حسب توفرها وضرورتها. تم اجراء تصنيف الاورام وتدريجها اعتمادا على معايير الاتحاد الدولي لمكافحة سرطان الاورام - (UICC - TNM) واللجنة الامريكية المشتركة لمرحلة مكافحة السرطان. تم تقسيم النساء المصابات بسرطان الثدي الى مجموعات فرعية على اساس مراحل السرطان ؛ المجموعة (ا) : تشمل 12 امراة في المرحلة الاولى (T1N0M0) ، حيث حجم الورم <2 سم ، المجموعة ب : 14 امراة في المرحلة الثانية (T2N0M0 ، T2N1M0 ، T3N0M0) ، حجم الورم (2 - 5) سم ومجموعة C : تشمل 12 امراة في المرحلة الثالثة (T2N2M0 ، T3N1M0 ، T3N2M0 وT4N2M0) ، كما كان لديهم حجم الورم > 5 سم. في هذه الدراسة تم استبعاد النساء المصابات بسرطان الثدي في المرحلة المتقدمة (المرحلة الرابعة) ، والنساء اللواتي يعانين من المرض سابقا او اللواتي يعانين من انواع اخرى من السرطانات؛ السرطانات التناسلية الانثوية (سرطان المبيض ، سرطان عنق الرحم ، سرطان الرحم) ، اورام الكلى ، القولون والمستقيم ، البنكرياس ، الرئة والراس والعنق. ايضا ، تم استبعاد المدخنين والنساء اللواتي يتناولن المشروبات الكحولية من هذه الدراسة. تم سحب عينة الدم من كل امراة لقياس VEGF ، M - CSF ،TIMP - 2,MMP - 2 و3 CA15 - . ايضا تم قياس مصل 25 هيدروكسي فيتامين D (25OHD) ومعلمات الدهون بما في ذلك الكولسترول الكلي (TC) ، والدهون الثلاثية (TG) ، والكوليسترول الدهني عالي الكثافة (HDL - C) ، والكولسترول الدهني منخفض الكثافة (LDL - C) فقط في المجموعة الاولى والمجموعة الثانية | Breast cancer (BC) is the most common malignancy in women and the second leading cause of their death from cancer in the world. The most effective way to combat cancer is its prevention and early detection. During the last decade, biochemical markers of breast cancer have attracted the attention of many researchers. Among these biomarkers, the interest points to Vascular Endothelial Growth Factor (VEGF), Macrophage Colony Stimulating Factor (M - CSF), Matrix Metalloproteinase - 2 (MMP - 2), Tissue Inhibitors of Metalloproteinase - 2 (TIMP - 2). Growing evidence indicates that measurement of VEGF maybe the best candidate for BC diagnosis (better than CA 15 - 3) especially in stages I and II as well as in the differentiation between BC and benign breast tumor. More recently it has been reported that TIMP - 2 maybe useful in early diagnosis of BC and differentiation of breast cancer stages. The aim of this study are to : (1) Measure the plasma concentrations of some of new biomarkers including : Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinase - 2 (MMP - 2), Tissue Inhibitor of Metalloproteinase - 2 (TIMP - 2) and Macrophage - Colony Stimulating Factor (M - CSF) in addition to CA 15 - 3 in women patients with breast tumor in compare son with healthy control women, (2) Investigate the diagnostic utility of each of the measured biomarker (and in combination with each other) in detection of breast tumor and (3) Correlate the findings with the clinicopathological parameters (age, menopause, marital status, stages, tumor size, Estrogen Receptor (ER), Progesterone Receptor (PR) and Her - 2/neu receptor) in those patients.Subjects and Methods : Eighty - eight Iraqi women were enrolled in the study; 38 women with primary breast cancer (BC, Group I), 25 women with Fibroadenoma (FA) benign breast tumor (FA, Group II) and 25 apparently healthy women (served as control group). The diagnosis of breast tumor was achieved by the Oncology group. Histopathology investigations were performed by Consultant Histopathologic based on tissue biopsy of mammary tumor or after mastectomy. Tumor classification and staging were performed depending on criteria of International Union against Cancer Tumor - Node - Metastasis (UICC - TNM) classification and the American Joint Committee on Cancer Staging. Accordingly, women with breast cancer were classified into subgroups based on the stage of their BC; Group A : 12 women with stage I, Group B : 14 women with stage II, and Group C : 12 women with stage III. Exclusion criterion includes those women with breast cancer of advanced stage (stage IV), a previous history of multiple type of cancers; female reproductive tract cancers (ovarian, cervical and endometrial cancers), renal, colorectal, pancreatic, lung, head and neck tumors. Blood sample was aspirated from each woman for the measurement of plasma VEGF, M - CSF, MMP - 2, TIMP - 2 and serum CA15 - 3 by using enzyme linked immunosorbent assay (ELISA). Also, serum vitamin D3 was measured in group I only using ELISA and serum lipid profile parameters were measured in group I and group II. Results : The mean (±SD) values of plasma levels of VEGF (p<0.001), MMP - 2 (p< 0.001), TIMP - 2 (p < 0.001), M - CSF (p < 0.05), and CA 15 - 3 (p<0.001) of group I was significantly higher compared to that of group II and controls. However, the mean value of plasma MMP - 2 was the only measured biochemical marker which was significantly increased in group II compared to controls (p<0.001). Regarding the BC stages, the mean values of all the measured biochemical markers were significantly higher in stage III than in stage I and stage II (p<0.001). Interestingly, the mean (± SD) value of plasma TIMP - 2 levels was the only biochemical marker of the measured ones which was significantly increased in stage II than in stage I (p=0.001). The cut - point value of plasma VEGF (>55.73 pg/ml) or TIMP - 2 (>102 ng/ml) (for both, AUC=1.0) was the excellent test in differentiating women with stage I of BC from healthy women. While that of VEGF (>55.73 pg/ml), TIMP - 2 (>102 pg/ml) or CA15 - 3 (>10.82 u/ml) (for all, AUC=1.0) was considered as the best test in discriminating the BC stage II from healthy women. While, the cut - point value of plasma TIMP - 2 (>142 ng/ml) which has the highest (AUC=1.0) considered as the excellent test in differentiating BC stage I from women with fibroadenoma benign tumor (FA). While that of VEGF (>88.67 pg/ml) or TIMP - 2 (>254 ng/ml) which has the highest (for each, AUC=0.991) was considered as the best test in discriminating the BC stage II from FA. In addition, the plasma measurement of VEGF has the superior diagnostic utility in differentiation of FA women and healthy control women (p<0.001, AUC=0.998).Conclusion : Measurement of plasma VEGF (cutoff >55.22pg/ml) or TIMP - 2 (cutoff >102 ng/ml) is the best biochemical marker in diagnosis of stage I or stage II BC and differentiates them from healthy women; they have more diagnostic utility than CA 15 - 3. Also, measurement of TIMP (cutoff > 142 ng/ml) has the excellent diagnostic utility in diagnosis and differentiation of stage I BC from benign tumor fibroadenoma (FA). Moreover, TIMP - 2 (cutoff > 254 ng/ml) or VEGF (cutoff > 88.67 pg/ml) has the superior diagnostic utility over that of CA 15 - 3 in diagnosis and differentiation of stage II BC from FA. Plasma measurement of TIMP - 2 was the best biochemical marker in studying early progression of BC; it can differentiate stage II from stage I BC. Furthermore, plasma measurement of VEGF was found to be the excellent parameter in differentiation between women with FA from healthy ones.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
السنة: 2018
الموضوع العام: الطب
اسم المشرف: باسل عويد محمد صالح كفاح حمدان
اسم المؤلف: اسيل نبيل كامل

دراسة الوظائف الانقباضية والارتخائية للبطينين الايون والايسر لدى مرض ارتفاع ضغط الدم بواسطة التصوير بالدوبلر النسيجي لصدى القلب Right Ventricular versus Left Ventricular Systolic and Diastolic Parameters using Tissue Doppler Echocardiography in Hypertensive patients

المستخلص: Background : Hypertension is a heterogeneous disorder with a number of well defined as well as putative etiologies. It is a major risk factor for stroke and cardiovascular diseases, and is thus associated with significant morbidity and mortality.Arterial systemic hypertension may determine impairment of both left ventricular diastolic and systolic function, due to increased afterload but also to changes of left ventricular geometry and structure producing left ventricular remodelling and hypertrophy.Also the right ventricle might be involved in this process by structural and functional abnormalities. Right ventricular chamber diastolic dysfunction has been shown in uncomplicated arterial hypertension [30, 41, 42, 43]. To date, little information is available about functional changes of right ventricular walls in arterial systemic hypertension. This issue is crucial to better understanding of the mechanisms underlying right ventricular involvement in the hypertensive heart. Pulsed tissue Doppler has been used to analyze myocardial left ventricular wall motion abnormalities in several cardiac pathologies [45 - 50] and also appears suitable for assessing changes of right ventricular longitudinal function due to arterial hypertension.Aims : This study evaluates Right & Left ventricular functional and morphological changes in treated hypertensive patients using selected conventional and Tissue Doppler Echocardiographic methods, and Studies the relationship between changes in both Right & Left Ventricles of heart. Finally to determine the relationship between onset of disease and echocardiographic changes.Methods and Results : We selected one hundred and two treated hypertensive patients and 100 healthy age - and gender - matched controls, both study groups underwent echocardiographic examination using 2D, M Mode, Pulsed Doppler and Tissue Doppler imaging.Examination involved left ventricular septal and posterior wall thicknesses, internal dimensions, left atrial area, ejection fraction and LV mass, also Tissue Doppler derived waves' velocities S' , e', a' and e'\a' ratio. Right ventricular internal basal diastolic dimension, free wall thickness in diastole, right atrial area, TAPSE, PASP, fractional area change(FAC), PW tricuspid inflow waves' velocities e, a, and e\a ratio, Tissue Doppler derived myocardial performance index (MPI), S', e', a', and e'\a' ratio.Hypertensive patients had Higher than controls in : Left Ventricular walls' thicknesses, end diastolic dimension, LV mass, left atrial area, peak velocity S', a', Right Ventricular free wall thickness, Tricuspid inflow TV a wave velocity, right atrial area, PASP, TDI S' and a' waves velocities.Lower Values than controls in Left Ventricular TDI peak velocity of e' wave and e'\a' ratio, Right ventricular Tricuspid inflow PW e wave velocity, e\a ratio, internal diastolic dimension, TDI e' and e'\a' ratio.The systolic function of both ventricles was not reduced.The diastolic function of both left and right ventricles were impaired, the Tissue Doppler derived e'\a' ratios were strongly correlated in both ventricles.There was a strong correlation between LVH and both Tissue Doppler derived RV & LV diastolic dysfunction.By studying correlation of echocardiographic finding with disease duration there was a strong relationship with both LVH and RV tissue Doppler diastolic dysfunction.Conclusion : Systemic arterial hypertension causes morphological and functional changes in both ventricles, initially systolic function of LV and RV are not affected; diastolic dysfunction in LV is considered as one of the earliest functional changes, studying RV revealed diastolic dysfunction which was strongly correlated with LV diastolic dysfunction by using Tissue Doppler imaging, also with LVH were highly correlated with disease duration.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: صدى القلب
السنة: 2014
الموضوع العام: الطب
اسم المشرف: حسن علي الفرحان
اسم المؤلف: مصطفى عبد الامير حسين زاهد

تفاعل انزيم البلمرة المتسلسل النسخي العكسي ذي الوقت الواقعي كاداة تشخيصية جزيئية في التحري عن الجينات المدمجة الشائعة في عينة من الاطفال العراقيين المصابين بابيضاض الدم اللمفاوي الحاد Real time reverse transcriptase polymerase chain reaction as diagnostic molecular tool in screening of common fusion genes in sample of Iraqi children with acute lymphoblastic leukemia

المستخلص: ابيضاض الدم الليمفاوي الحاد عند الاطفال هو مرض متنوع له اصناف وراثية متعددة تستجيب بصورة مختلفة للعلاج الكيميائي. توجد الكثير من التغايرات الكروموسومية المؤدية الى انتاج جينات مدمجة مصاحبة لحدوث هذا المرض.اهداف الدراسة : لدراسة تعبير الجينات المدمجة الشائعة في ابيضاض الدم اللمفاوي الحاد عند الاطفال باستخدام تقنية تفاعل البلمرة المتسلسل ذي الزمن الواقعي وربط نتائج هذه الدراسة مع مختلف المؤشرات السريرية والمختبرية ثم تقييم هذا التعبير بعد العلاج الاولي.المرضى, المواد وطرق العمل : اجريت هذه الدراسة المستقبلية للحالات والشواهد باستخدام تقنية تفاعل البلمرة المتسلسل ذي الزمن الواقعي لدراسة تعبير الجينات المدمجة MLL - AF4 ,BCR - ABL1 ,E2A - PBX1 ,TEL - AML1 وSIL - TAL1 في ناضح نقي العظم ل 48 مريض بابيضاض الدم اللمفاوي الحاد قبل العلاج مع 46 شخوص ضابطة, تم جمعها من مستشفى حماية الطفل التعليمي / دائرة مدينة الطب للفترة من 1 تموز 2013 الى 31 حزيران 2014. استعمل جين GAPDH كجين مراقب داخلي لدراسة تعبير الجينات المذكورة بعد العلاج.النتائج : من اصل 48 مريض بابيضاض الدم اللمفاوي الحاد, كان هناك 21 ذكرا" و27 انثى مع نسبة ذكور الى الاناث 0.78 : 1 . تراوحت اعمارهم بين 2 شهر الى 13 عام مع متوسط عمر 5 اعوام . تراوحت اعمار 26 مريضا" بين 1 - 5 سنوات. اظهر الفحص الجزيئي الكشف عن نسخ الجينات المدمجة TEL - AML1، E2A - PBX1 وp190 1BCR - ABL في 20.8%, 16.7% و2.1% من المرضى، على التوالي، بينما لم يتم الكشف عن نسخ p210 1BCR - ABL ، MLL - AF4 وSIL - TAL1. بالاضافة الى ذلك، اظهر احد المرضى تعبير نسخي لكل من TEL - AML1 وE2A - PBX1 في الوقت نفسه. وجدت التعابير الجينية بعد بدء العلاج في 2 مرضى من اصل 12 مريض.الاستنتاجات : ان تقنية تفاعل البلمرة المتسلسل ذي الزمن الواقعي طريقة جزيئية دقيقة وقابلة للتطبيق في تصنيف ابيضاض الدم اللمفاوي الحاد في الاطفال. ان نتائج التصنيف الجزيئي للاطفال العراقيين المصابين بابيضاض الدم اللمفاوي الحاد مشابهة نوعا" ما للتقارير العالمية جاعلة TEL - AML1 الجين المدمج الاكثر انتشارا". | Pediatric acute lymphoblastic leukemia is a heterogeneous disease with various genetic subtypes that respond differently to treatment. Many chromosomal aberrations with resultant fusion genes are known to be associated with the disease.Objectives : To study the expression of common fusion genes in pediatric acute lymphoblastic leukemia using a quantitative real time polymerase chain reaction technique, correlate results with different clinical and laboratory findings and evaluate these expressions after initial treatment.Subjects, materials and methods : A case - control prospective study was conducted using qPCR technique to study the expression of TEL - AML1, E2A - PBX1, BCR - ABL1, MLL - AF4 and SIL - TAL1 fusion genes in bone marrow aspirates of 48 untreated acute lymphoblastic leukemia pediatric patients and 46 control subjects, were recruited at the Children Welfare teaching hospital / Medical City directorate for the period from 1st of July 2013 to 31st of June 2014. Post - induction transcripts’ evaluation for 12 ALL patients was done by comparative quantification method using GAPDH as a reference gene.Results : Out of 48 acute lymphoblastic leukemia patients, 21 were males and 27 were females with a male to female ratio of 0.78 : 1. Age ranged from (2 months to 13 years) with 26 patients aged between 1 - 5 years whereas the median age was 5 years. The mean age was 5.9 years + standard error of 0.51 years. Molecular screening demonstrated detection of TEL - AML1, E2A - PBX1 and BCR - ABL1 p190 transcripts in 20.8%, 16.7% and 2.1% of patients, respectively. BCR - ABL1 p210, MLL - AF4 and SIL - TAL1 transcripts were not expressed. One patient expressed both TEL - AML1 and E2A - PBX1 transcripts. Post induction transcripts were detected in 2 out of 12 patients.Conclusions : Real time PCR technique is an applicable molecular method in classifying and predicting prognosis in pediatric ALL. The molecular classification of Iraqi children with ALL is mostly similar to reports worldwide making TEL - AML1 fusion gene the most prevalent type
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
الموضوع الدقيق: الامراض - الدم
السنة: 2015
الموضوع العام: الطب
اسم المشرف: بان عباس عبد المجيد سلمى عباس الحداد
اسم المؤلف: اريج عماد كاظم

الاهمية السريرية لدراسة كهروفسلجـة القلب لدى مرضى التسارع الاذيني الانتيابي حول العقدة الاذينية البطينية CLINICAL IMPORTANCE OF CARDIAC ELECTROPHYSIOLOGICAL STUDY IN PATEINTS WITH ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA

المستخلص: تعتبردراسة كهروفسلجة القلب من الفحوصات القسطارية الضرورية لدى المرضى المصابيين بالتسارع الاذيني الانتيابي والذي يحدث بسسب ظاهرة عودة الدخول الكهربائي حول العقده الاذينية البطينية. تهدف هذه الدراسة الى معرفة الاهمية السريرية لكهروفسلجة القلب في تقييم مرضى التسارع الاذيني الانتيابي حول العقده الاذينيه . لقد خضعوا جميع المرضى الى اجراء قسطرة كهربائية القلب وخلال هذه العملية تتم دراسة كهروفسلجة القلب حيث تم مراقبة التوصيل الكهربائي بين حزمة هز والبطينين وتثبيت سرعة التيار الكهربائي بين الاذين والبطين اثناء التسارع الانتيابي. وشملت هذه الدراسةتسعة وثلاثون مريض من كلا الجنسين وباعمار مختلفة. ومن خلال دراسة كهروفسلجة القلب لديهم تم تقسيمهم الى مجموعتيين المجموعه النموذجية الاكثر انتشارا حسب قياسات المسافة بين البطين والاذين اثناء التسارع الاذيني الانتيابي والتي تكون اقل من 60 مل/ثانيه. وكان عددهم ثلاثة وثلاثون مريض. والمجوعة الثانية وهي اللانموذجية والاقل شيوعا وكان عددهم ستة مرضى. والمسافة بين البطين والاذين اثناء التسارع الانتيابي اكثر من 60 مل/الثانيه. اظهرت النتائج الى ان اكثر من نصف المرضى تكون العقده الاذينيه الحبيبه ذات فيزيولجية ثنائية الذراع (البطيئ والسريع) 62% وهو الغالب في العادة، ولكن من خلال هذه الدراسة وجدت نسبة تكاد تكون عالية 38% نسبيا بين هولاء المرضى حيث كانت العقدة الاذينية البطينية ثلاثية او رباعية الذراع حيث يشترك اكثر من ذراع بطيئ في التسارع الانتيابي. بعد الاعتماد على نتائج الدراسة وتحديد نوع التسارع الاذيني الانتيابي يتم كوي الحزمه الكهربائية في الذراع البطيئ بعد تحديد مكان الذراع بالاعتماد على التشريح والموقع اثناء الدراسة. مع الاخذ بنظر الاعتبار ان جميع المرضى تم كوي الذراع لهم وبشكل ناجح ولكن القسم الاكبر 59% تم قطع الذراع بشكل تام حيث لاثوجد اي اشارات لكهروفسلجة القلب بعد الكوي والقسم الاخر تم كوي الذراع بشكل غير كامل او تغير في التركيب التشريحي للذراع وكانوا 41% من المرضى بالاعتماد على وجود بعض المواصفات من البداية من دون رجوع التسارع الاذيني الانتيابي بعد الكوي خلال تحفيز القلب بعد الكوي. وتم الاستنتاج من خلال الدراسة ان النساء يعانون بنسبة اكبر من تسارع فوق الاذيني المنتظم مقارنة بالرجال. مع وجود نسبة ليست بالقليلة والتي تصل الى ثمانية وثلاثون بالمئة من المرضى تكون فيها فزيولوجية العقده الاذينيه ثلاثية او رباعية الذراع مقارنة بالفيزيولوجية ثنائية الذراع وهو الشائع بالعادة. | AV nodal reentrant tachycardia (AVNRT) considered as the most common regular supraventricular arrhythmia in humans. It originates from a location within the heart above the bundle of His. It is more common in women than men. It represents an important cause of palpitations and to lesser extent, dizzy spells and syncope. An invasive electrophysiological study is a helpful procedure in the classification of AVNRT into common (typical) and uncommon (atypical) types. This study aims to : (1) Assess the role of electrophysiological study in the classification of AVNRT. (2) Explore the presence of multiple pathways in respect to the usual dual AV nodal pathways. And (3) Used EP study as predictor for successful ablation of the slow pathway. This study was conducted on Thirty nine (39) patients of either sex with paroxysmal supraventricular tachycardia corresponding to an AVNRT referred for catheter ablation. Each subject was submitted for history taking, examination, ECG, Echo study and basic invasive cardiac electrophysiological procedure that include right - sided cardiac catheterization through the femoral veins and programmed pacing was performed after localization of the catheters in the heart using the standard stimulation protocol to induce the tachycardia. In addition, His bundle study which involve measurement of atrial - His (AH) interval, Ventricular - atrial time (VA) as a baseline and after tachycardia induction, demonstration of the AH jump and/or echo beat (ectopic) pre and post ablation of the slow pathway using radiofrequency energy. However this study was conducted in Leipzig Heart Center/Germany from January 2013 to February 2014. The result of this study reveals that 33 (84.6%) of the patients developed typical AVNRT and 6 (15.4%) with atypical AVNRT. 25 patients (64.1%) were females (23 (92%) typical type and 2 (8%) atypical type) and 14 patients (35.9%) were males (10 (71.4%) typical type and 4 (28.6%) atypical type). Among the patients group with typical AVNRT the 91.7% discovered to have two AV nodal pathways and 84.6% with three pathways in respect to 8.3% with two AV nodal pathway and 15.4% with three pathways within the patients group with atypical AVNRT. Accordingly, 38.5% of all patients in this study discovered to have multiple pathways. Concerning ablation and modification of the slow pathway, complete ablation is achieved in 59% while modification of the pathways was noticed in 41%. In conclusion, this study concludes that an invasive electrophysiological study is a safe and reliable method for identification of patients with high risk of tachyarrhythmias. Moreover, most of the female patients discovered to have typical AVNRT. Unusually, higher percent of patients developed multiple pathways (more than two pathways) with respect to the usual dual pathways. The disappearance of post ablation EP data (AH jump and/or echo beat) reflect successful complete slow pathways ablation whereas the appearance of these data considered being a modification of the slow pathway
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
الموضوع الدقيق: الامراض - القلب
السنة: 2014
الموضوع العام: الطب
اسم المؤلف: امـين عبد الحسن مانع العـلواني

الدور الحتمل لكشف المستضد كالتومانان في مجال التشخيص المختبري من الرشاشيات الهوائية في مرضى نقص المانعة The possible role of galactomannan antigen detection in laboratory diagnosis of invasive Aspergillosis in immunocompromised patients

المستخلص: This study was conducted to detect the invasive aspergillosis inimmunocompromised patients with rapid diagnostic method (ELISA).This study was conducted on 50 immunocompromised patients, theywere the attendants of Hematology / Oncology Department of BaghdadTeaching Hospital, pediatric oncology wards. The patients presented withfever which is not responding to antibiotics along with cough and sputumand abnormality on chest x - ray . And 11 healthy Iraqi individuals wereincluded in this study. from March 2013 till October 2013.Sputum and serum. initially direct microscopical examination donefor each sample and stained with gram stain. Sputum was immediatelycultured on Sabouraud dextrose agar (SAB) and Brain heart infusion agar(BHI) labeled with same code number of that sputum. Wet preparationwas down from colonies on Sabouraud dextrose agar plate or Brain heartinfution agar for isolation and identification of species of growingmould.This study showed that female to male ratio among patients studygroup was (1.2 : 1) .The age of the patients ranged from from 2 to 70 years with a meanage (31.8 ± 0.8) years. For the control the age ranged from 11 to 60 yearswith a mean age (31.1 ± 0.1) years. The peak mean age group (10 - 20)years with (5.1 ± 0.1).This study showed that 33( 66%) of patients were havingneutropenia which it is highly significant = 11.58 when the P value(P<0.01) , 10 ( 20% ) of patients were having neutrophilia and 7 (14%)of patients were having normal blood film results.IIThis study showed that sputum culture for Aspergillus positive in 18cases and it was negative in 17 patients, it was not done in 15 casesbecause some are from patients were sputum sampling was difficult to beobtained (pediatric), or have no sputum . And the Aspergillus speciesisolated from this culture showed that Aspergillus fumigatus is the most common species isolated from sputum culture 11 (61.1%) of positive culture results.The results showed high significant of AML diseases which composed 18 of 50 (36%) of patients , and most of the patients 24 of 50 (48%) of patients were on amphotericin B treatment.The results of the detection of galactomannan antigen detected by ELISA showed that the difference between the mean cutoff value of the patients and the control group was statistically significant (T = 0.135 and P value <0.05). In patient study group the ELISA test was positive in 39 of 50 (78% ) which it is highly significant when compared with noncancerous control group who were all negative 11 of 11 (100%) at p - value <0.001.Finally this study showed that (28 of 50) 56% of patients were dead because they are have invasive pulmonary aspergillosis (IPA) which is serious and potentially fatal disease that might kill the patients if any delay occurs in lab. diagnosis. So early diagnosis of invasive pulmonary aspergillosis may give higher cure rates.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: ماجستير
الموضوع الدقيق: الاحياء المجهرية
السنة: 2014
الموضوع العام: الطب
اسم المشرف: وفاق محمود الوتار علي محمد جواد
اسم المؤلف: رواء علي محمد

دراسة التعبير الوراثي للجينات P53, KRAS, c - MYC & Her - 2/neu وانواع الرنا المايكريوية miR - 21, 34a, 92 & 98 على عينات ماخوذة من الغسول القصبي والانصباب الجنبي لمرضى مصابين بسرطان الرئة ومرضى مصابين بامراض رئوية مزمنة غير سرطانية Expression of P53, KRAS, c - MYC, Her - 2/neu genes and microRNAs 21, 34a, 92 & 98 in cancerous and non - cancerous bronchial wash and pleural aspirate

المستخلص: Background : Lung cancer is the leading cause of death from cancer in men all over the world. Most of newly diagnosed cases were in advanced stage and beyond radical treatment due to late appearance of worrying symptoms and absence of effective screening method for high risk groups. Nowadays, depending on recent advances in molecular studies researches are directed toward finding molecular markers for diagnostic, therapeutic and prognostic purposes. Aim of study : To investigate the possibility of using expression of P53, KRAS, Her - 2/neu, c - MYC and microRNAs 21, 34a, 92, and 98 as a molecular biomarkers for detection of lung cancer in samples of bronchial wash and pleural fluid. Material and Methods : A prospective case control study on a total of 120 samples, sixty bronchial washes and sixty pleural effusions. The samples were taken from patients recruited at the Thoracic Surgical Unit in the Specialized Surgery Hospital/ Medical City during the period from March 2012 to April 2014. The work was performed in the Department of pathology and forensic Medicine, Baghdad college of Medicine. The specimens were thirty bronchial wash and thirty pleural fluid samples positive for lung cancer cells by cytopathology, and similar number of negative samples. Studied genes were amplified using qRT - Realtime PCR. Housekeeping genes for normalization of mRNAs was GAPDH and RNU - 48 for microRNAs. Expression was calculated using equation; Expression = (2 - ΔΔCt). Results : Results of Ct values for each marker were obtained from Max Pro 5000 Agilent Technology PCR software and raw and standardized Ct values were analysed using SPSS - 22 software. The mean, standard deviation, t - test, ANOVA test and LSD (least significant difference) were obtained before and after normalization. A statistically significant differences in the expressions of p53, KRAS, c - MYC, Her - 2/neu and microRNAs, 21, 34a, 92, & 98 genes were found between positive and negative (control) samples with a significant p - values of <0.05. Conclusion : According to this study a conclusion could be reached; the study of expression profiles of mRNAs of P53, KRAS, c - MYC, Her - 2/neu and microRNAs 21, 34a, 92 and 98 genes can be used as a biomarker in the detection of lung cancer, differentiating subtypes, and screening of high risk groups
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
الموضوع الدقيق: الامراض
السنة: 2015
الموضوع العام: الطب
اسم المشرف: بان عباس عبد المجيد عدنان الجبوري
اسم المؤلف: حسين عبادي الجبوري

استخدام الصبغة المناعية p16INK4a والتهجين الموقعي وتاثيرها على فحوصات عنق الرحم الصحيحة والملتبسة The Use of p16INK4a and In Situ Hybridization and Their Impact on the Healthy and Equivocal Pap Smears of the Cervix

المستخلص: Throughout the past thirty years, the perception of cervicalcarcinoma has shifted from that of a mysteriously fatal disease, to one ofthe sexually transmitted, human papillomavirus (HPV) related infection.HPV DNA has been found in almost all cervical invasive and preinvasivecervical neoplasms.Conventional Pap smear, which was established in the early sixtiesreduced effectively the morbidity and mortality related to cervical cancer.Given the lower sensitivity of the Pap cytology test, new diagnosticparameters have been established. The histological features ofpreinvasive cervical neoplasia (CIN1, CIN2, and CIN3) are wellunderstood. However, misinterpretation of the morphological criteriacould lead to significant variability.The aim of this study is to identify women with equivocal and normalPap smear who are at risk for developing cervical cancer through the useof p16INK4a immunostaining and human papillomavirus (HPV) DNAtesting using in situ hybridization (ISH).Materials and MethodsIn order to identify human papillomavirus infection in minorcytological and histological abnormalities, biopsies collected from 60women 25 - 66 years of age with normal cervices and Pap smears (groupI), abnormal cervices and Pap smears (group II) and with cervicalcarcinoma (groupIII) referred to the Colposcopy Clinic in BaghdadTeaching Hospital - Medical City Complex, during the period from June2013 through July 2014. Cytology samples collected with ThinPrep forIVliquid base cytology (LBC), punch biopsy for histopathology formalinfixed and paraffin embedded. In situ hybridization (ISH) and p16INK4aimmunohistochemistry in addition to routine hematoxylin and eosin(H&E) stain were used to evaluate the histological specimens.ResultsThe age, age of marriage and parity of the three groups werestudied in relation to each of ISH and p16INK4a reactions. Agedistribution was highly significant among all age groups; in both ISH andp16 test results GI &GII (p=0.00), GI & GIII (p=0.00), GII &GIII(p=0.00) in both ISH and p16 test results. The age of marriage was notsignificant among the groups in both ISH and p16; GI & GII p (0.93), GI&GIII (0.12), GII &GIII (0.30). The effect of parity was insignificantamong all groups; GI & GII = (p = 0.66), GI & GIII (p = 0.82), GII &GIII (p = 0.79) in both ISH and p16 test resultsp16INK4a immunoreaction : Among group I there was a negativereaction in all the specimens collected. In specimens from group II, therewas a very mild or focal p16INK4a immunoreaction in one specimen(5%), a moderate immunoreactivity in 9 specimens (45%), and a highpositive reactivity in 10 specimens (50%) (p=0.000). Group III showedvery high immunoreaction in all the specimens collected.In situ hybridization (ISH) in group I was mild positive in 4specimens (20%) which showed diffuse signal pattern. A mild positivereaction with diffuse nuclear staining was noticed in 4 (20%) of thecervical specimens. Moderate positive reaction with diffuse staining ofthe nucleus was observed in 8 (40%) of the specimens. The remaining 8(40%) of the specimens showed both diffuse and punctate staining of theVnuclei. Among group III specimens, the nuclei in the epithelial cellsshowed both punctate and diffuse signal patterns.Chi square was done to compare results concerning ISH & variousgroups was highly significant (p= 0.00) ConclusionHPV infection is prevalent and can be missed by the conventional Pap smear. The severity of the disease was directly proportional with the age of women in this study. p16 overexpression was correlated with the positivity of ISH. This may support the use of either, or both, tests to improve the accuracy of cervical intraepithelial neoplasia (CIN) diagnosis, and help in the triage of women with equivocal lesions.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دكتوراه
الموضوع الدقيق: التشريح والانسجة والاجنة
السنة: 2015
الموضوع العام: الطب
اسم المشرف: ندى صالح امين هدى مهدي الخطيب
اسم المؤلف: ثناء جميل الخشالي

التقييم السريري ورصد قياس التاكسج خلال الليل للمرضى المعرضين لخطر توقف التنفس الانسدادي اثناء النوم Clinical Evaluation and Overnight Oximetry Monitoring of High Risk Patients for Obstructive Sleep Apnea

المستخلص: Obstructive sleep apnea OSA is a condition of sleep related pharyngeal collapse, in which recurrent episodes of upper airway occlusion occur during sleep causing diminution (hypopnea) or cessation of airflow (apnea) in the pharynx provoking arousals and sleep fragmentation , resulting in daytime sleepiness. Aim of study : To evaluate patients at high risk of OSA, by clinical parameters and overnight oximetry monitoring.Patients and Method : Cross sectional study of 20 patients, 12 male and 8 female with high probability of OSA, attended to respiratory clinic in Baghdad teaching hospital suffering from excessive daytime sleepiness, they were clinically evaluated plus using overnight oximetry as an objective testing method.Results : 20 patients only complete the study, 12 male (60%), 8 female (40%), 4 patients >60 years old (20%), 9 patients 40 - 59 (45%), and 7 patients 20 - 40 (35%), smokers were 11 (55%), patients with hypertension were 8 (40%) all of them with regular anti - hypertensive drugs , 2 (10%) patients were hypothyroidism according to thyroid function test .DI show significant correlation with AHI, BMI, Baseline SPO2 and gender, while no significant correlation with age.AHI show significant correlation with baseline SPO 2 and gender, and no correlation with BMI and age.Conclusion : Desaturation index assessed by nocturnal pulse oximetry maintain its utility as a screening method in the recognition of obstructive sleep apnea in morbidly obese patients with high clinical pretest suspicion, DI > 4% when combined with appropriate clinical evaluation, could be used as an initial diagnostic test for OSA.Obesity is a major risk factor and almost all suspected patients with OSA are obese.
الصفحات الاولى:
مكان الجامعة: بغداد
اللغة: الانكليزية
الدرجة: دبلوم عالي
الموضوع الدقيق: الامراض - الصدرية
السنة: 2014
الموضوع العام: الطب
اسم المشرف: قاسم محمد سلطان
اسم المؤلف: محمد شاكر حسن