Author name:
هادي هلال حمزة
Supervisor name:
هلال بهجت شوقي الصفار
Abstract:
Atherosclerosis is very common disease involving large and medium size arteries result in morbidity and mortality depend on site of vascular involvement. Aim of the study : To study the extent of other vascular beds involvement in patient presented with coronary artery disease.Patients & Methods : This study is prospective cross - sectional study of all patients who were referred Iraqi Center for heart disease, for further evaluation of suspected coronary artery disease(CAD) for the period August 2016 to February 2017. The total number of patients was one hundred ninety (190) ,all underwent full clinical evaluation, laboratory investigation including ECG, biochemical testing, echocardiography, coronary angiography,. demographic characteristics were recorded for all patients including ,age, gender, BMI, conventional risk factors, carotid IMT measurement by Doppler ultrasound and ABI by Doppler stethoscope was calculated. The study sample was divided into two groups according to the results of coronary angiography : group A, those with normal CA and group B, those with abnormal CA. A comparison was made between group A and B as regard to the results of IMT and ABI measurement and then the relation to demographic characteristics and other conventional risk factors. Then we study the subgroup with abnormal ABI & IMT in both group A and B, comparison was made between both subgroup in form , gender, age groups , mean age, and the detail of risk factors like hypertension, smoking, diabetes mellitus , BMI, family history of premature CAD and hyperlipidemia . Results : The mean age, patients above 60 y and men gender were higher in group A( 58.82), (52.09%) and (76.4%) than in group B (52.93) ,(25.4%) and 45.07% (p value 0.010)The study of risk factors in both groups demonstrate more prevalence of hypertension in group A (63.05%) than in group B (47.8%) , ( p value 0.0499), also significance difference in prevalence of diabetes mellitus and smoking (52.9%) and (43.6%) in group A and (26.7%) and (15.4%) in group B ( p value 0.0276 and 0.0437) , prevalence of hyperlipidemia was significantly higher in group A (55.4%) than in group B( 35.3%) (p value 0.0418) . family history of premature CAD and BMI were higher in group A (41.1%) and (40.3%) than in group B (33.8%) and (26.7%) but not statistically significant (p value 0.194 and 0.154 ) respectively.The prevalence of abnormal ABI and IMT were higher and statistically significant in group A (36.9%) and (77.3%) than in group B (15.4%)and (30.9%) (p value 0.002 and 0.001). The no. patients with abnormal both carotid IMT and ABI were higher in group A (37/44, 84.09%) than in group B (8/11, 72.7% ) , (p value 0.041), the mean age is higher and statistically significant in group A (68.49) than in group B (57.5) ( p value 0.030) , the male gender is higher and statistically significant in group A(33/37, 75%) than in group B (4/8, 50%) ( p value 0.010). the prevalence of hypertension, hyperlipidemia and diabetes mellitus were higher and statistically significantly in group A (83.7%), (83.7%) and (75.6%) than in group B (75%) ,(62.5%) and (37.5%) (p value 0.0476, 0.0346 and 0.047) respectively. The prevalence of smoking , abnormal BMI and family history of premature CAD were higher but statistically insignificant in group A (67.5%) , (56.7%), and (48.6%) than in group B (37.5%), (37.5%) and (37.5%) (p value 0.0868, 0.146 and 0.2136) .Conclusion : Atherosclerosis is generalized process whenever found in certain vascular bed, we must think of other vascular beds involvement, the more risk factors burden the more likely involvement of other vascular bed and more sever disease to be expected.
