مشاركة
عسر شحميات الدم اعتلال المفاصل الصدفي الفعال : دراسة حالة ضابط == Dyslipidemia in Active Psoriatic Arthropathy Case Control Study
اسم المؤلف:
منار هشام صابر
اسم المشرف:
عبد اللطيف جاسم
الموضوع العام:
الطب
السنة:
2018
الموضوع الدقيق:
الامراض - المفاصل
الدرجة:
دبلوم عالي
الجامعة:
جامعة بغداد - كلية الطب
اللغة:
الانكليزية
مكان الجامعة:
بغداد
الصفحات الاولى:
19T1477 - p.pdf
المستخلص:
Psoriasis is a chronic inflammatory skin condition characterized by scaly erythematous plaques on body surfaces. Psoriatic arthritis (PsA) is a unique, clinically heterogeneous type of inflammatory arthritis associated with skin psoriasis.Atherogenic dyslipidemia comprises a triad of increased blood concentrations of small, dense low‐density lipoprotein (LDL), decreased high‐density lipoprotein (HDL) particles, and increased triglycerides. Most recently, a relationship between psoriasis and increased risk of myocardial infarction, cerebrovascular disease, and peripheral vascular (cardiovascular) disease has been reported.Objectives : This study aimed to shed the light on dyslipidemia in psoriatic arthropathy patients and to determine any association between lipid abnormalities and disease activity.Patients and Methods : This study is a case control study which was conducted on 84 patients in Rheumatology and Dermatology department/ Baghdad Teaching hospital and 90 healthy controls for 8 months' period from August 2017 to April 2018. All patients with confirmed cases of Psoriatic arthritis according to CASPAR criteria. Data collected and analyzed according to patient history and Physical examination were including age, gender, body mass index, education level, occupation, smoking status, disease duration and disease activity score ,presence or history of dactylitis and enthesitis, history of diabetes, hypertension and hypercholesterolemia, cardiovascular diseases, and drug history of Disease - modifying antirheumatic drugs (DMARDs) and (anti - TNF agents), lipid lowering drug ,use of fish oil with its duration . Laboratory parameters were also taken including ESR and lipid profile.Results : Total number of the patient in this study was 84 and controls were ninety.The mean age was (42.6)years, 51% were male . There was no significant difference in age, gender and BMI between patients and control. Cholesterol, triglyceride and LDL were significantly higher in patients compared to controls p value <0.001 . There was no significant difference in the (Cholesterol, TG, HDL, LDL, and Atherogenic index) between low and moderate to high disease activity. There was direct significant correlation between cholesterol with TNFI duration p value (0.039 ) Conclusions Patients with psoriatic arthritis had elevated levels of cholesterol, TG, LDL and atherogenic index. There is a direct association between high level of cholesterol and the duration of TNF inhibitor treatment. The current study shows that, no relation between disease activity and lipidprofile abnormality
