مشاركة
اثار العلاج الاشعاعي على اختبار وظيفة الغدة الدرقية في سرطان الراس والعنق == Effects of Radiotherapy on Thyroid Function Test in Head and Neck Cancers
اسم المؤلف:
زينة عماد عمران
اسم المشرف:
خضير جاسم صبيح الرواق
الموضوع العام:
الطب
السنة:
2018
الموضوع الدقيق:
الاشعة العلاجية
الدرجة:
دبلوم عالي
الجامعة:
جامعة بغداد - كلية الطب
اللغة:
الانكليزية
مكان الجامعة:
بغداد
الصفحات الاولى:
19T1481 - p.pdf
المستخلص:
Background : Patients with head and neck cancers are often treated with external beam radiation therapy with or without surgery and / or chemotherapy. While radiation to the neck area may involve part or whole of thyroid gland ,the well - known side effect of hypothyroidism will subsequently ensue. Aim : to evaluate the risk of developing hypothyroidism after radiotherapy in patients with head & neck malignancies. Patients and methods : This is a prospective study of 40 patients of head and neck cancer, receiving radiotherapy in Baghdad center of radiotherapy from October 2017 to January 2018. TSH,T3 and T4 estimations were done at baseline and at 4 months following radiotherapy. Results : Before radiotherapy, all study patients showed normal T3, T4, and TSH levels with a mean of 1.88 ± 0.22, 123.92 ± 6.97, and 2.19 ± 0.67 respectively.After radiotherapy, all patients showed normal T3 and T4 with a mean of 1.8 ± 0.19 and 121.52 ± 8.86 respectively; while 12.5% of study patient showed elevated TSH level with a mean of 2.63 ± 1.44.The mean of TSH after radiotherapy was significantly higher than that before radiation (2.63 versus 2.19, P=0.044) while no statistical significant change in mean of T3 and T4 levels before and after radiation (P ≥ 0.05). The highest prevalence of elevated TSH level was seen in patients who had a history of surgery to head and neck (40%) with a significant association (P=0.047) between prevalence of elevated TSH level and past surgical history. There was no significant association (P ≥ 0.05) between prevalence of elevated TSH level and all other characteristics.Conclusions : The likelihood of thyroid dysfunction after radiation therapy is common and can initially manifested within 4 months and addition of surgery to radiation therapy can increase the risk of hypothyroidism by 40%.
