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تقييم مستوى مصل حمض البوليك لمرض الانسداد الرئوي المزمن وعلاقته بشدة المرض وتكرار الانتكاسات : دراسة الحالات والشواهد == ASSESSMENT OF SERUM URIC ACID LEVEL IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATION TO DISEASE SEVERITY AND EXACERBATION FREQUENCY (Case - Control Study

اسم المؤلف: الاء عبد الجبار

اسم المشرف: عدنان محمد الجبوري

الموضوع العام: الطب

السنة: 2018

الموضوع الدقيق: الامراض - الصدرية

الدرجة: دبلوم عالي

الجامعة: جامعة بغداد - كلية الطب

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى: 📎 19T1483 - p.pdf

المستخلص: Background : Chronic obstructive pulmonary disease (COPD) is a major contributor to morbidity worldwide,and lead to damage lung tissue and so lead to reduce oxygen intake resulting in tissue hypoxia.Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in production of serum uric acid.Identification of prognostic biomarker for COPD as serum uric acid(sUA) may aid in improving survival .Objective of the study : Evaluate role of hyperuricemia in disease severity and exacerbation frequency in COPD patients.Method : Case - control study was conducted from 1st of December 2017 to 1st of June 2018, on 80 subjects in Baghdad teaching hospital\medical city, 40 subjects with COPD, other 40 subjects are healthy persons consider as control, all >40 years old<70 .Serum uric acid level measured for all study sample.Excluded from this study those with Hx of Diabetes mellitus, Hypertension, Malignancy, Cardiac disease, Gout and persons on drugs affect sUA level.Results : The mean age for COPD was 61.9 while for control was 49.3 years.Serum utic acid higher in male than female in both group. In COPD cases there are higher level of serum uric acid compared to control and COPD patients had 3.16 time more risk to developed high serum uric acid than persons without disease also there was a significant statistical association between mean sUA and duration and degree of COPD (P value<0.05).Conclusion : Patients with COPD have higher serum uric acid level than control group, which tend to increase with increase in duration and severity of disease.