Author name:
محمد رياض عبد العزيز عبد الرزاق
Supervisor name:
صلاح شاكر هاشم اللعيبي | عدنان جاسم الفرطوسي
Abstract:
Given the importance of drug Prednisolone and the diversity of its uses as a treatment in many diseases such as asthma and kidney symmetry and rheumatoid arthritis and multiple sclerosis, and facial nerve paralysis syndrome and psoriasis ...... and others , and contribution to us as researchers , to reduce the suffering of patients with those diseases of the large number of patient use the drug in large doses and at different times during the day so the current study included the preparation of a hydrogel polymer networks (natural - industrial) Interpenetrating and semi Interpenetrating networks (P1, P2, P3, P4 - 1, P4 - 2, P4 - 3, P4 - 4, P5 - 1, P5 - 2, P5 - 3, P5 - 4, P6 - 1, P6 - 2, P6 - 3, P6 - 4) diagnosed in FT - IR spectrum. This study included study of swelling ratio of prepared polymeric networks at constant temperature (37 M◦ ± 1 M◦) and different PH value [ distilled water (pH = 7), Simulated Gastric Fluid SGF solution (pH = 1.2) and the Simulated Intestinal Fluid {SIF ( pH = 8.2)]. The highest swelling ratio showed of polymeric networks prepared in the Simulated gastric fluid (SGF) and then distilled water (H2O) and finally means the Simulated Intestinal Fluid (SIF) .The polymeric networks (P1, P2, P3, P4 - 4, P5 - 4, P6 - 4 ) have the largest swelling ratio of compared with other polymeric networks prepared in this study.Carrying a Prednisolone drug on polymeric networks (P1, P2, P3, P4 - 4, P5 - 4, P6 - 4) were followed gradual release in three different solutions, (H2O), (SGF) and (SIF). The result shown the highest release ratio of the drug in the (SGF) and then (H2O) and finally means Simulated Intestinal Fluid (SIF), in order to obtain a loaded system polymeric new bearing high doses of the drug at a rate controlled by release natural dose stipulated according to the body's need and thus staged the continuity of the drug did for long periods, which helps the patient psychologically. Results of a study gradual liberalization of drug Prednisolone the polymeric network (P5 - 4) gave high efficiency in loading the drug as well as in the gradual release , Lethal to half number of animals is (1.6 g / kg = LD50).Studied the effectiveness of anti - inflammatory to (P5 - 4) sustained drug Prednisolone as systems gradually on laboratory mice (in vivo), and important tests edema of the palm of mice induced by Carrageenan and edema permission induced by Xylene mice . The results shown that the (P5 - 4)polymeric network loaded with drug Prednisolone prevented the edema induced by carrageenan and xylene , and give Significant differences (P <0.05) after (0.5, 0.1 hours) and a high significant (P <0.01) after (2, 4, 6, 8,10 hours) and continued activity up to 23 hours from the start of the dosing time. It showed results of a study the effect of Chitosan as an antiinflammatory Appearance of significant differences (P <0.05) after( 0.5, 1.2, 4.6 hours) and highly significant (P <0.01) after (8,10, 23 hours) of the dosing time, and shown the drug Prednisolone alone for significant differences (P <0.05) after (0.5, 1 hour) and highly significant (P <0.01) after (2,4 hours) all of the dosing time, after which there was a decrease activity as an antiinflammatory,which lasts until the end of the probationary period
