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تحضير وتقييم ودراسة الاطلاق المسيطر عليه للكيتوبروفين المحمل على بوليمرات ذات خاصية لاصقة للمواد المخاطية == Preparation, evaluation and study controlled release ketoprofen from mucoadhesive polymers
Author name:
سرور وليد عبد الرضا الكناني
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University Of Basrah - College Of Education For Pure Sciences
Language:
Arabic
University location:
Basrah
First pages:
25T1588 - p.pdf
Abstract:
We have used ketoprofen which is found in the local pharmacy and ketoprofen was separated and purified and then measured the melting point and (λ max) were determined for the purpose of ascertainig the purity of the material used.The microspheres were prepared with Sodium alginate by using Sodium alginate with Chitosan and without Chitosan and by using Calcium chloride a cross - linking agent, the microspheres and drug were characterized by IR and photomicrographs microscopy.In vitrostudy of drug release and kinetics of drug release were studied in simulated Gastric fiuid (SGF) and simulated Intensinal fluid (SIF). The results exhibit that the pH value effected on releaseing rate of drug from microspheres, also the samples gave ahigh release rate in pH=(8.2)(SIF) comparison with low values of pH=(1.2) (SGF) .Study The effect of different process parameters such as drug /polymer ratio and sodium alginate /chitosan ratio,on the morphology, size distribution and drug release. The microspheres diameters were found between (400 - 900) μm The rate of ketoprofen released was increased with the increasing of concentration of drug in the microspheresThe release of drug deareasing with increase of polymers. The coefficient of determination indicated that the release data was best fitted with zero order kinetics , Higuchi equation explains the diffusion controlled release mechainism.In this study Nine polymer hydrogel compound were prepared (GI - G9). semi Interpenetra ting polymeric hydrogel (IPNS). From synthuetic polymers Poly electrolyte with poly acrylamide The swelling146146characteristics were studied for all microspheres and semi - IPN hydrogels by determining the swelling ratio (Q)in three differnt pH, it was found that it . depending on components quantities and enoironments.We Niosomes loaded with ketoprofen were prepard and studied rate release drug in (pH=7.4) was studied with decreasing . The results showed that the releasing is increase of Cholesterol, Niosomes was succeeded in cover kp . also prepared gel of Niosomes and Carbopol934 by different concentration of Niosomes and Carbopol934 , The results showed that by ahigh release of drug deincreasing the concentration of Carbopol934 .In biological part , the results show that biological activities of the microspheres loaded with kp exceed biological activities against three types of fungal isolates including Candida albicans, and staphylocoecas aureus in comparison with activity of kp alone.The study consist on the toxicity of these materials which is shown that these materials are nontoxic.
