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تحضير ودراسة بايلوجية لبعض مركبات البايرزول == Preparation and biological study of some pyrazole compounds
Author name:
خنساء صقر سعود
Supervisor name:
نزار لطيف شهاب الدين
General topic:
Chemistry
Specific topic:
Chemistry
Degree:
Master
University:
University Of Basrah - College Of Education For Pure Sciences
Language:
Arabic
University location:
Basrah
First pages:
25T1582 - p.pdf
Abstract:
The present study includes the preparation of some pyrazolines derivatives includes their characterization and their biological activity.Chapter one the introduction shows the literature survey and related important reactions for pyrazolines .While chapter two shows the details of the preparation for each types in details 36 pyrazoline product were prepared from 6 types of (cha/cones) Benzalacetophenones and six different hydrazine ( hydrazinehydrate , phenylhydrazine, semicarbazide, thiosemicarbazide 2,4 - dinitrophenylhydrazine and phenylthiosemocarbazide ).Chapter three shows all the results which proved the chemical structures of some selected compounds by using I.R, 1H - NMR, 13C - NMR, CHN, and mass. Spectroscopy we found abnormal case in pyrazoline derivatives especially in the ring once have - CH2 like in (P1and P10) and compounds (P8 and P13) does not have the methylene protons this exception was happened due to modification in procedure. Finally the biological activity for some selected compounds were used and compared with standard drugs and its shows moderately to good activity.
