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العوامل المؤثرة على نوعية حياة المرضى المصابين بالجلطة الدماغية في مركز الفرات الاوسط للعلوم العصبية في مدينة النجف الاشرف == Factors Affecting Quality Of Life For Patients With Cerebrovascular Accident In Middle Euphrates Neuroscience Center In Al - Najaf Al - Ashraf City

اسم المؤلف: احمد صالح رضا القاضي
اسم المشرف: سحر ادهم علي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: خلفية الدراسة : تعتبر الجلطة الدماغية سبب رئيسي مؤثر يقلل مستوى نوعية حياة المرضى. قياس نوعية الحياة للاشخاص الذين يعانون من امراض مزمنة يعطي رؤية واضحة لتحديد اثره على مقدمي الرعاية الصحية عندما تكون النتيجة غير ممكنه. العوامل المؤثرة على نوعية الحياة لم | Background : Cerebrovascular accident is a main leading cause affectedly decrease the level of quality of life of the patients. The measurement of quality of life for population with chronic diseases gives a clear view to determine the impact on health care providers when prognosis is not possible. Factors affecting the quality of life may be vary between different age categorize such as CVA young and old CVA patients, different factors have affected the quality of life, related to the following aspects : motor impairment, physical dysfunction or dependency in activity of daily living, the presence of depression ,cognitive impairment, and speech disturbances.The main aim of the study : To identify the factors affecting the quality of life for patients suffering from cerebrovascular accident.Design of the study : Descriptive cross - sectional study design was selected to achieve the objectives of this study the factors affecting quality of life for patients diagnosed with cerebrovascular accident in Middle Euphrates Neuroscience center in Al - Najaf Al - Ashraf City, for the period between 27 October 2015 and 30 August 2016.Setting : A unique center was selected to conduct the study, the outpatient department in Middle Euphrates Neuroscience center in Al Najaf Al Ashraf City are used to collect the data.Sample of the study : Non probability ( purposive sample ) from patients with CVA (N=80) were selected to find out the factors affecting quality of life for patients with cerebral vascular accident. Data was collected by using an assessment questionnaire which was adopted and developed by the researcher to assess the factors affecting the quality of life for patients with cerebrovascular accident. It is divided of three parts : demographical data as the first part, clinical information is the second part, while the specific CVA quality of life questionnaire which extended to 48 items distributed upon 12 main domains as (energy and activity, family relationship, speaking, movement, mood, personality, self - care, social role, thinking, in addition upper extremities functions, vision, and work / productive ) is the third part. Validity of the questionnaire obtain by (19) experts, who work in different fields to obtain the reability of the questionnaire alpha cronbach was used as a statistical method.The majority of the study sample were between (59 - 69) of age. The highest percentage of the study sample were males and were married. On the other hand the highest percentage of the sample were illiterate , housewives and urban area residents. The scores of the quality of life of the majority of the study sample were high effected regarding the following domains : (energy and activity), plus movement, moderate effect presented related to the family relationship, speaking, mood, self - management, social role, thinking, function of the upper extremities, vision, and job / productive, while low effect score recorded for personality.Conclusion : The overall quality of life level of the CVA patient who participate in the study was moderate. The QOL for patient with CVA were significantly effected related to their age, occupation, and educational level. Chronic diseases, type of CVA and it's duration play as highly effecting factors related to the patient's quality of life.Recommendation : Establishing structured program realizing the challenges that might face the post CVA patients because this long journey need special planned care to improve patient's quality of life by special rehabilitation unit, the unit services may be extended for the patient's family.

قياس تركيز الحديد والفرتين والارثروبويتين وفيتامين ب وحامض الفولك والبيروكسايديز الدرقي في مصل مرضى تضخم الغدة الدرقية حديثي التشخيص في محافظة بابل == Serum Iron,Ferritin,Thyroid Peroxidase ,B12,Erythropoietin And Folate Concentrations In Patients With Newly Diagnosed Hyperthyroidism In Babylon Province

اسم المؤلف: سالينا عبد العباس ناصر الشمري
اسم المشرف: محمد عبيد المحمدي | علاء صادق العواد
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: فرط نشاط الغده الدرقيه : هو مرض يصيب الغده الدرقيه وذلك نظرا لارتفاع هرمون تي ثلاثه وتي اربعه وهما هرمونات الدرقيه ولوحظ ان هذا المرض يصيب النساء بنسبه اعلى من الرجال بسبب التاثير الهرموني للاناث مما يجعلها الاكثر عرضه لهذا المرض,من علامات هذا المرض هي زيا | Background : Hyperthyroidism is endocrine disease that occur due to high levels of thyroid gland hormones and this disease affected female more than male due to hormonal effect, the female is more susceptible to this disease.Sign of disease including increase in metabolic rate of patient,sweating,increase pulse,enlargement of thyroid gland(goiter) which by this sign can diagnosis the patient.Objective : Evaluate serum erythropoietin and its relation with increase metabolic rate as well as hemopoiesis,evaluate serum folic acid and vitamin B12 and its role in hyperthyroidism ,evaluate the correlation of thyroid peroxidase with thyroid hormones and evaluate serum iron and ferritin.Materials and methods : This study was done from October/2015 till July/2016.The total number of patients group in this study was seventy man and women.their age ranged 26 - 65 years,58 women and 12 men who was in patients group and 35 female and 5 male in control group.Patients data in this study was history of hypertension ,parity ,age and sex. The difficulty in my research was in collection of spa icemen from patients.Result : The result which obtained from this study found that high significant increase in ferritin,thyroid peroxidase,folate and erythropoietin (p?0.01) in patients as compare to control group.High significant decrease in iron and B12(p?0.01) in patients group compare to control group. in case of the age found the 30 - 39 years more effected age among patients group and the female more effected with disease than male.Conclusion : From this study we conclude that thehyperthyroidism in female more than male due to hormonal effect. Reduce in iron due to high metabolic rate lead to decrease absorption of iron and B12 which lead to anemia.increase thyroid peroxidase which play a role in T3 and T4 synthesis.

Effect Of SNP rs198389 of BNP Gene On The Natriuretic Peptides Levels In Cardiovascular Patients

اسم المؤلف: Alaa Salman Idan Al - Ibrahimi
اسم المشرف: Monem M. Al | shok | Moaed E. Al | Gazally
الموضوع العام: الطب
السنة: 2016
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: Acute coronary syndrome (ACS) refers to any group of acute signs and symptoms attributed to sever obstruction of the coronary arteries. Acute coronary syndrome usually occurs because of one of three problems : ST elevation myocardial infarction, non - ST elevation myocardial infarction, and unstable angina. These types are named according to the results of the electrocardiogram (ECG). In addition to clinical and electrocardiogram (ECG) findings, several biochemical markers are considered in patients with chest pain to diagnose myocardial ischemia. Heart failure (HF) according to American College of Cardiology (ACC) and American Heart Association (AHA) is a complex clinical syndrome that can be caused by any structural or functional disorder in the heart that fails the capability of the ventricle to fill with or to eject blood. The diagnosis is often performed clinically on the basis of the presence of dyspnea, fatigue, signs of fluid overload, such as pulmonary crepitation, peripheral edema, and distension of jugular vein.B - type natriuretic peptide (BNP) and N - terminal pro - BNP (NT - proBNP) are secreted by human atrial and ventricular myocardium. The rise in BNP and NT - proBNP levels after ACS and HF correlates with infarct size and regional wall motion abnormalities. Echocardiography remains the most frequently used and usually the initial imaging test to evaluate all cardiovascular diseases related to a structural, functional, or hemodynamic abnormality of the heart or great vessels. This study is designed to investigate and assess the serum concentrations of BNP and NT - proBNP in patients with HF and ACS; In addition, almost equal number of males and females are chosen to control the effect of age and gender on the levels of BNP and NT - proBNP. Also, the study aims to evaluate the effect of BNP gene T - 381C (rs198389) polymorphism on the plasma human levels of BNP and NT - proBNP and compare the results that will obtain with healthy control.The present study was involved (70) patients, (35) of them with ACS and the other (35) with HF. The study also includes (22) subjects were taken as control group. The sera obtained from the blood of patients and control subjects were used to measure the concentrations of BNP and NT - proBNP, while whole blood samples from study subjects are used to extract DNA for the study of polymorphism in BNP gene.The results indicate both the ACS and HF groups have significantly higher levels of BNP and NT - proBNP when compared to control group, also HF patients have higher levels of both parameters than ACS patients, in all comparison (p

تاثير كل من عقار الروزوفاستاتين وعقار الاتورفاستاتين على مؤشرات نسب السكر المصاحبة للسمنة المحدثة في الفئران == Effects Of Atorvastatin Versus Rosuvastatin On Glycaemic Indices In Diet Induced Obese Mice

اسم المؤلف: نورس لطيف وهاب
اسم المشرف: علي اسماعيل عبد الله محمد | حيدر مطير القريشي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Numerous interventional cardiovascular disease outcome studies have resulted in statins being an essential factor of cardiovascular primary and secondary prevention strategies.In recent years there was ahigh concern that statin use is associated with diabetes new onset which is strong, independent risk factor for cardiovascular (CV) and cerebrovascular outcomes ,several studies resulted in conflicting results regarding different statin types & dose effect on glycemic control. Atorvastatin which is the most widely used statin worldwide and rosuvastatin the most efficacious ;they have different structural characteristics that have been speculated to have influence on diabetes onset.Aim of the study : The present study aims at investigating the effect of different doses of atorvastatin and rosuvastatin on glycaemic indices and metabolic disorders on mice model of diet induced obesity. Materials and method : The animals were divided into two groups : one served as control that received normal regular chow & the other group received high fat diet for the whole 12 weeks of experiment.After eight weeks of HFD feeding ;group (2) farther subdivided into five groups(12 mice in each) ; the first group received HFD only ,the second group received single daily dose / po of 20mg /kg rosuvastatin ,the third group received single daily dose / po of 40mg /kg rosuvastatin ,the fourth group received single daily dose / po of 20mg /kg atorvastatin ,and the fifth group received single daily dose / po of 40mg /kg atorvastatin for the last four weeks of experiment.Body weight ,food intake, lipid profile ,glycaemic indices were taken at baseline ,before treatment and after treatment.At the end of experiment ,animals were sacrificed , plasma & tissue sample were collected for biochemical analysis and histological observations.Results : Results of the present study shows that high fat diet feeding resulted in obesity development and metabolic abnormality like; hyperglycemia ,hyperinsulinemia ,insulin resistance , dyslipidemia and moderate to severe hepatic steatohepetitis compared to control group. and treatment resulted in significant improvement in lipid profile ,reduction in food intake ,body weight ,also associated with improvement in insulin sensitivity , hepatic steatohepetitis and reduction in insulin secretion.twenty mg/kg dose of atorvastatin showed better influence on glycaemic indices and comparable influence on hepatic picture over fourty mg/kg does while twenty mg/kg dose of rosuvastatin resulted in deterioration of glycaemic indices and no apparent improvement in hepatic steatosis. Unlike group that received 40 mg /kg rosuvastatin which showed significant improvement in all related metabolic disorders. Conclusion : Feeding mice with high calories diet for 2 month result in induction of obesity and disturbance of metabolic parameters. Treatment with rosuvastatin or atorvastatin has good impact on bodyweight , metabolic derangements &hepatic steatosis in obese mice. Both drugs seems to improve lipid profile in dose dependent manner, however their effects on glycaemic indices has different attitude. It is seems that rosuvastatin, especially at high dose, has better impact on glycaemic indices than atorvastatin and this might attributed to the difference in their pharmacokinetic properties

تاثير استخدام عقار الميتفورمين منفردا او مع عقار السيتاكلبتين على مستويات الاومنتين - 1 لدى مرضى داء السكري من النوع الثاني == Effects Of Metformin Alone Or In Combination With Sitagliptin On Serum Omentin - 1 Levels In Patients With Type - 2 Diabetes Mellitus

اسم المؤلف: ميقات طالب حمادة
اسم المشرف: حيدر مطير خليل القريشي | عبد الكريم يحيى السامرائي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الخلفية : داء السكري يشير الى مجموعة من امراض الايض مع ارتفاع مستوى سكر الدم. يمثل النوع الثاني من داء السكري ما نسبته 90 - 95% من جميع حالات السكري. يمثل النقص في الانسولين ومقاومة الانسولين وغيرها من الاضطرابات الهرمونية المشاكل الاساسية لمرضى السكري من ال | Background : Diabetes mellitus (DM) describes chronic metabolic disorders with hyperglycemia. Type II DM (T2DM) represents for approximately 90 - 95% of all diabetic types. A combination of insulin deficiency, insulin resistance and other hormonal irregularities are key problems with T2DM. Adipose tissue can be classified into two types : the brown and white adipose tissues. The white type is considered an important secretory organ which produces many bioactive molecules, collectively termed adipokines. Recently, a new adipokine named omentin - 1, has been identified and it was found that individuals with impairment in glucose homeostasis and newly diagnosed T2DM showed a lower serum omentin - 1 level. However, the effects of antidiabetes drugs on serum omentin - 1 level had not been studied extensively.Objective : The current study was design to measure serum omentin - 1 in T2DM as comparing with control subjects, also to study the effect of three months therapy with metformin and/or sitagliptin (when added to ongoing metformin therapy) on serum omentin - 1 levels in addition to other parameters.Method : This study was carried out on thirty healthy control subjects, and sixty three T2DM patients. The patients enrolled in the current study were divided into two groups. First group : included thirty one of newly diagnosed T2DM patients, started treatment with metformin. Second group : included thirty two patients with T2DM, already on ongoing metformin therapy and started treatment with sitagliptin. All patients received their treatment for three months duration, and blood samples were collected from them at the beginning of the study and after three months of starting treatment to measure the possible change in the studied parameters which include : fasting blood glucose (FBG), postprandial blood glucose (PBG), Glycosylated haemoglobin (HbA1c), serum level of insulin, insulin resistance (IR), serum omentin - 1 levels, lipid profile, body mass index (BMI) as well as blood pressure. Results : The results showed that baseline level of serum omentin - 1 in the newly diagnosed T2DM was significantly lower than matched control subjects. The level of omentin - 1 was significantly reduced after three months duration of treatment in sitagliptin group with no significant change in metformin group. FBG, HbA1c and PBG were decreased significantly after three months in metformin group, while in sitagliptin group, only HbA1c and PBG were decreased significantly after three months. In both groups, and after three months duration of treatment, there were no significant changes in serum level of insulin, IR, TG, VLDL - C, HDL - C, BMI, and blood pressure.Conclusion : In newly diagnosed patients with T2DM, serum omentin - 1 was reduced compared to age and BMI matched healthy subjects. Three months treatment with sitagliptin resulted in a significant reduction in omentin - 1 levels compared with baseline values. However, three months treatment with metformin had no significant effect on serum omentin - 1 level compared with pre - treatment value

تاثير استخدام عقار الكلورال هيدريت منفردا او استعماله مجتمعا مع عقار الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال == Chloral Hydrate Alone Or In Combination With Diazepam As A Sedative For Auditory Brainstem Response Testing In A Pediatric

اسم المؤلف: مريم محمد حميد مصطفى
اسم المشرف: حيدر مطير خليل القريشي | حيدر وهاب السرحان
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لبحث تاثير استخدام الكلورال هيدريت منفردا او استعماله مع الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال من اجل تقييم ما اذا كان اضافة الديازيبام له تاثير ايجابي او سلبي.اعتمدت الدراسة الحاليه على160 متطوعا من الاطفال ال | Background : children usually need sedation for diagnostic and therapeutic interventions. It is well known that pediatrics age groups are at higher risk for sedation - related complications than adults. Auditory brainstem response testing is one of the important diagnostic procedure that usually need sedation in order to preformed in children. Chloral hydrate is a hypnotic agent used since 1832 with low incidence of adverse events; whoever, despite the world wide use it is being abandoned due to bitter test, long time of sedation onset, vomiting and mild sedation. Rectally diazepam, on the other hand, produces higher and fast concentration in CSF with greater rate of success but probably with higher adverse events. Aim of the study : were to compare the sedative effect of chloral hydrate with chloral hydrate diazepam combination as well as their related adverse effects in children underwentg auditory brainstem response testing. Methods : in this randomized clinical study, 160 child underwent sedation for auditory brainstem response test participated. They were divided equally and randomly into 4 groups. Group A : Received 20 mg/Kg oral chloral hydrate as sedative, Group B : Received 20 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally, Group C : Received 40 mg/Kg oral chloral hydrate as sedative, and Group D : Received 40 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally. At the beginning, blood pressure, respiratory rates, peripheral oxygen saturation recorded, and then re - recorded immediately after drug administration and at (3, 5, 10, 20, …. min). Ramsay sedation scale used for assessment of the sedation level which measured every 10 min. Results : This study shown the beneficial use of chloral hydrate in combination with diazepam as sedation in ABR test (in groups D) by increased in the sedated number (p<0.05), decreased in the requirement of chloral hydrate re - dose, increased in the number of children whom completed ABR test (p<0.05) without significant differences on side effects or vital signs compared with the others three groups. 4.3. Conclusion : From this study we concluded that : • Used of oral chloral hydrate in dose (20mg/kg) alone not sufficient as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (20mg/kg) in combination with rectal diazepam (0.5 mg/kg) better than used it alone as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (40mg/kg) in combination with rectal diazepam (0.5 mg/kg) was the best sedative in paediatrics for ABR test. • Used of Chloral hydrate diazepam combination in ABR test of paediatrics increased the number of the sedated children, decreased the requirement of chloral hydrate re - dose, and increased the number of completed ABR test, with less complication

عزل وتحديد هوية فيروس الحصبة في علاقته ببعض الجوانب المناعية من الاشخاص النازحين الملقحين في محافظة بابل == Isolation And Identification Of Measles Virus In Relation To Some Immunological Aspects From The Vaccinated Displaced Individuals In Babylon Governorate

اسم المؤلف: ليث احمد عمران كيف الكيف
اسم المشرف: محمد عبد كاظم حسن السعدي | يونس عبد الرضا كحيوش الخفاجي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة لتقييم مناعة المجتمع لكلا النازحين والمقيمين الملقحين بلقاح فيروس الحصبة ضد خمج الحصبة في محافظة بابل. لذا تضمنت هذه الدراسة معايرة الحالة المناعية في امصال النازحين والمقيمين محافظة بابل مع عزل وتشخيص فيروس الحصبة من الحالات المشتبه بها. ت | The study was conducted to evaluate the herd immunity for both the displaced and residents vaccinated with measles virus vaccine against measles infection in Babylon governorate. Therefore this study includes the evaluation of the immune status in sera of Babylon governorate displaced and residents with specific aspect for isolation and identification of measles virus from suspected cases. The immune response was evaluated by means of ELISA test (enzyme linked immunosorbet assay) for titration of IgM and IgG immunoglobulin level, in addition to evaluation of perforin level in the sera of 90 measles vaccinated individuals included in this study (50 displaced and 40 residents) from different areas in Babylon governorate, that were collected during the period extent from January up to April of 2016. Data about individuals were fixed according to information of formula including age, sex, geographical location, place displace of displaced and the vaccination date. Successful virus isolation from suspected cases on two types of cells culture included Vero cells line and chicken embryo fibroblast was carried. The titer of the isolated virus on Vero cell line reached (105.8 TCID50 / 0.1ml),which was higher than the titer of the virus isolated on CEF which reach (105.4 TCID50 / 0.1ml) after the third passage of the virus. The isolated virus was confirmed by indirect immunofluorescence technique.The age of subjects included in this study ranged from <1 year up to 24 years old. The results revealed that 15 (30%) have positive IgM index in sera of displaced, whereas residents sera sample shown only 6 (15%) positivity. Howover, all 90 (100%) subjects of both groups showed positive IgG index. The results of the present study showed that there were no significant difference of perforin level in sera of refugees and residents at p<0.05.Assaying of immune response against measles virus by measuring IgM immunoglobulin in sera of vaccinated displaced and resident with measles vaccine reflected a highly significant difference between two groups which reached 0.43 mIU/ml in sera of displaced in comparison with residents sera which reached 0.34 mIU/ml. The result showed also high significant differences in IgM between females and males. The females sera IgM levels of displaced and residents were higher than its level in males sera which reached 0.47 mIU/ml and 0.35 mIU/ml, respectively, in comparison with male sera level which reached 0.40 mIU/ml and 0.32 mIU/ml, respectively. According to age group, the highest IgM value was recorded in displaced and residents sera in age group 10 - 14years (0.50 mIU/ml) and 5 - 9years (0.36 mIU/ml) respec - tively. Whereas the lowest IgM serum value was detected in age group <1 year (0.34 mIU/ml) and 15 - 19years (0.31 mIU/ml) for displaced and residents subjects. According to geographical location, the highest IgM level was detected in sera of displaced from Tal Afar city (0.44 mIU/ml) followed by displaced from Ramadi (0.41 mIU/ml) and the lowest IgM value was detected in sera of displaced from Mosul city (0.33 mIU/ml). Whereas the highest IgM value in sera of residents in the subjects of Al - Mahaweel city (0.37 mIU/ml) followed by subjects of Hilla and Al - Qasem city (0.29 mIU/ml and 0.28 mIU/ml) respectively. For IgG serum immunoglobulin the results revealed that there was no difference in significant levels in both group population. But according to age groups significant difference between displaced and residents was detected at p <0.05 in which the 1 - 4 years old showed the highest IgG serum level in both group (1.98 mIU/ml and 2.18 mIU/ml) respectively. While the lowest IgG sera value was recorded in displaced age group of < 1 year old (0.60 mIU/ml) compared with residents age group of 20 - 24 years old (1.65 mIU/ml).It could be concluded that the results showed that the displaced do not have any effect on the residents of the province of Babylon for measles as a result of the good immunization by Babil Health directorate following to the Ministry of Health.

تاثير استخدام عقار الميتفورمين منفردا او استعماله مجتمعا مع عقار كلكلزايد على مستوى الاومنتين - 1 - في مرضى داء السكري من النوع الثاني == Effects Of Metformin Alone Or In Combination With Gliclazide On Serum Omentin - 1 Levels In Patients With Type 2 Diabetes Mellitus

اسم المؤلف: سمر محمد غني سليمان
اسم المشرف: علي اسماعيل عبد الله محمد | حيدر فاضل الربيعي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لبحث التاثير العلاجي لاستخدام عقار الميتفورمين منفردا او استعماله مجتمعا مع عقار كلكلزايد على مستوى الاومنتين - 1 - باالاضافة الى المؤشرات الحيوية الاخرى في مرضى داء السكري من النوع الثاني من اجل تقييم ما اذا كان الجمع بين العقارين ( | Background : Omentin is a newly identified adipokine, which is highly expressed in visceral adipose tissue, in which omentin - 1 is the main isoform in human circulation, associated with cardio - metabolic disturbances. So considering the impact of anti - diabetic drug on omentin - 1 levels may provide adjuvant strategy to protect diabetic patients against clinical hazards.Aim of the study : The present study aimed to investigate the influence of treatment with metformin alone or in combination with gliclazide on the level of serum omentin - 1, in addition to the other biomarkers adopted in the study in order to evaluate whether the combined therapy (metformin plus gliclazide) ameliorate or adversely effects on some cardiac protector markers of metformin among recently diagnosed patients with type 2 diabetes mellitus.Methods : A total number of 100 recently diagnosed patients with type 2 diabetes mellitus were enrolled in the present study from December 2014 until June 2015. Sixty eight patients completed the 12 weeks course of treatment; divided into two equal groups based on treatment regimen in which group1 treated with metformin and group2 treated with metformin plus gliclazide. Thirty two patients did not complete the course of the treatment for unknown reasons and considered as default. In addition to 31 healthy volunteers were randomly chosen and considered as Control Group. In which all the participants in the study underwent detection of blood pressure, pulse rate, weight, height & BMI in addition to the estimation of the levels of others biochemical analysis as glycemic indices, lipid profile & serum omentin - 1at the beginning of the study & after 12 weeks of treatment regimen.Results : The results of this study shown the beneficial amelioration of metformin on some markers that affect CVS represented as significant reduction in BMI (p<0.05), modest improvement in lipid profile with modest elevation in HDL level & lowering blood pressure, significant reduction in the levels of blood glucose & HbA1C (p<0.05), improves insulin sensitivity, reduced insulin resistance, and elevation of serum omentin - 1 level among newly diagnosed type 2 diabetic patients (group1). Furthermore, the results of current study are revealed that adding of gliclazide to metformin in treatment of type 2 diabetic patients might influence the documented beneficial effects of metformin on cardiovascular system at least by adversely changing the levels of serum omentin - 1 among group 2. Conclusions : Adding of gliclazide to metformin in treatment of patients with type 2 DM might extend the therapeutic action of metformin in regarding much better controlling of glycemic indices, insulin sensitivity and lipid profile. But, at the same time, it might attenuate some of beneficial effects of metformin on cardiovascular system at least by adversely influence on body weight and serum omentin - 1 levels.

تاثير استخدام عقار النكلوزمايد بالمقارنة مع عقار المتفورمين على وزن الجسم ومؤشرات السكر في السمنة المحدثة عند الفئران == Effects Of Use Of Niclosamide Drug In Comparison With Metformin Drug On Body Weight And Glycemic Indices In High Fat Diet Induced Obese Mice

اسم المؤلف: خالد دهان صليبي
اسم المشرف: علي اسماعيل عبد الله محمد | خالد جمعة خليل
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: في ستينيات القرن الماضي كان هناك نوع من العلاجات تستخدم للسيطرة على وزن الجسم او لتخفيفه , تلك المواد تعمل على تثبيط عضيات المايتوكوندريا من انتاج الطاقة وتحويل مجرى تفاعلات الاكسدة نحو انتاج الحرارة بدلا عن الطاقة وبذلك تحفز من زيادة اكسدة الشحوم ومادة ا | Background : Obesity is a state of excessive accumulation of fat tissue in the body , increasing energy expenditure is good way to manage obesity and the related complications. Mitochondrial uncouplers increase energy expenditure , they used before for weight controlling programs because these compounds uncouple mitochondria from generating ATP , moreover stimulate lipid and glucose oxidation preventing lipid accumulation in excess caloric intake conditions specially. Niclosamide an old drug introduced in 1960s as anthelmintic and had FDA approval for the treatment of most of tapeworm infections. It is well known mitochondrial uncoupler.Aim of the study : The present study aimed to investigate the influence of trial of the use of niclosamide in comparison to effect of metformin and their combination on body weight , glycemic indices and lipid profile in high fat diet induced obese mice.Materials and methods : The animals firstly divided to two groups one fed with normal regular mouse chow (30 mice) and the 2nd fed with high fat diet (60%kcal) for 2.5 months(100 mice) 10 mice from each group sacrificed at beginning of study represent baseline values and another 10 mice from each group sacrificed after 2.5 months to assess effect of high fat diet on study parameters. The group that fed with high fat diet further subdivided to 4 groups after 2.5 month of high fat diet feeding each 20 mice , 10 mice from each group sacrificed before treatment represent pretreatment values. Before treatment there are 5 groups assigned as group 1 fed normal regular mouse chow till the end of study , group 2 fed high fat diet without treatment till the end of study , group 3 fed with high fat diet till the end of study and treated with niclosamide for one month (150mg/kg) after obesity induction by high fat diet , group 4 fed with high fat diet till the end and treated by metformin (300mg/kg) for one month and finally group 5 fed with high fat diet till the end of study and treated by combination of niclosamide and metformin (150mg/kg , 300mg/kg respectively). blood samples taken from tail vein to evaluate the study parameters at baseline and after obesity induction by high fat diet (after 2.5 months) and after treatment ,then animals were sacrificed and livers were taken for histopathological observations.Results : The results of this study shown that the animals fed with high fat diet show metabolic disturbances manifested by significant increase (P < 0.05) in body weight , fasting insulin & fasting plasma glucose. Lipid profile show significant changes (P < 0.05)(cholesterol , triglycerides ,low density lipoproteins increased while high density lipoproteins decreased ) as compared to control group. High fat diet group also show impaired glucose tolerance , impaired insulin sensitivity and obvious liver structural changes manifested by sever steatosis.Treatment with niclosamide show improvement in all metabolic disturbances induced by obesity ; body Weight , fasting insulin and fasting plasma glucose reduced significantly (P < 0.05). Lipid profile parameters improved ; cholesterol , triglycerides , low density lipoproteins reduced significantly (P < 0.05) by one month treatment with niclosamide and high density lipoproteins increased significantly (P < 0.05) as compared to their baseline values before treatment, Glucose and insulin tolerance improved. It is nice to mention the influence of niclosamide in this study was comparable to metformin in all evaluated parameters.Combination of both drugs show favorable improvement in metabolic disturbances induced by obesity rather than each drug when used alone specially on liver histopathological changes.Combination of both drugs show significant reduction (P < 0.05) in body weight ,fasting plasma glucose and fasting plasma insulin. Lipid profile parameters improved significantly (P < 0.05) , glucose and insulin tolerance improved.Liver histopathological changes ameliorated to higher extent and become the closet to normal liver tissue morphology.Conclusions : The result suggest niclosamide have good antidiabetic action and can ameliorate the metabolic changes induced by obesity significantly. Its action is comparable to that of well known antidiabetic drug metformin. Niclosamide has favorable effect on body weight and can reduce body weight. Its combination with metformin show better improvement in metabolic disturbances induced by obesity and it has very good hepatoprotective effect against liver histopathological changes induced by high fat diet.

تاثيرات السيتاكولين ,الجنسنك واستخدامهما معا على الذاكرة العملية والاداء الحركي النفسي == Effects Of Citicoline, Ginseng, And Their Combination On Psychomotor Performance And Working Memory

اسم المؤلف: تيسير لطيف علي
اسم المشرف: حيدر القريشي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اساس الدراسة : اجريت الدراسة الحالية لتقييم التاثير العلاجي لعقار السيتاكولين والجنسنك واستخدامهما معا على الذاكرة القصيرة المدى والاداء الحسي الحركي, وذلك من خلال دراسة الاثار المركزية والطرفية للعقارين على مقاييس الاداء الحسي الحركي , الذاكرة العمليه , | Citicoline is one of components that present in the human brain, which act to protect the neurons and enhance memory and other cognitive functions due to its choline in their structure which play an important role in the biological membrane biosynthesis. On other hand Ginseng is an herbal plant is known for its therapeutic medical importance, it's used for different purposes in medical fields, that is effective against many diseases, act as a tonic and provide energy with significant reduction in mental and physical fatigue.Aims of the study To evaluate the central effects of Panax Ginseng and/or citicoline on normal healthy volunteers.Material and Method The subjects are randomly divided into four groups for assessment of central effects of Panax Ginseng and /or citicoline compared with placebo. The evaluation of the central effects was done by using the Leeds psychomotor battery tester for evaluating the psychomotor performance, workshop test was used to evaluate working memory function.The enrolled volunteers were randomly divided into the following groups : First group regarded as control group that treated with 500 mg/day of starch capsule as a single dose, second group, received Panax Ginseng capsule 500 mg /day, a third group received citicoline capsule 500 mg/day and the fourth group received Panax Ginseng capsule 500 mg/day plus citicoline capsule 500 mg/day as a single dose. All participants are followed for two consecutive weeks from starting treatments.ResultsIn the present study the placebo didn't have any central effect and MDA serum levels were not significantly change. Panax Ginseng has statistically significant effect on the most parameters of the psychomotor performance, working memory performance, as well as reduction of MDA serum levels. On the other hand, citicoline has statistically a significant effects on most parameters of the psychomotor and working memory function with statistically significant reduction of MDA serum levels.The combination of Panax Ginseng and citicoline have a highly statistically significant effect on all psychomotor performance, working memory performance and statistically significant reduction in the oxidative stress marker (MDA). ConclusionResults of the present study showed that combined effects of citicoline plus Panax Ginseng on central function produced more statistically significant effects on psychomotor performances, CFFF and working memory function than either Panax Ginseng or citicoline when they used alone, in addition to the combined effects of citicoline plus Panax Ginseng have a more significant effect on the oxidative stress,during mental stress.

تقييم وحدات الرعاية المركزة لحديثي الولادة في ردهات الولادة لمستشفيات بغداد == Evaluation Of Neonatal Intensive Care Units At Maternity Wards In Baghdad Hospitals

اسم المؤلف: بشرى احمد عبد اللطيف
اسم المشرف: جمال محمود الخضيري
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تتباين انظمة الرعاية لحديثي الولادة المطبقة ولكنها كلها تعتمد على وحدات الخدج الموجودة في مختلف بلدان العالم النامية والمتقدمة.انجزت هذه الدراسة المقطعية التقويمية في وحدات حديثي الولادة لردهات الولادة في مستشفيات بغداد (الكرخ والرصافة) مستثنين وحدات ال | Neonatal health care is provided via a variety of neonatal care units that are available globally both in different developing and developed countries.A cross - sectional evaluation study was conducted in all accessible fifteen neonatal intensive care units in Baghdad (Kharkh and Rosafa) maternity wards, excluding paediatric hospitals, during the period from November 2013 till the end of March 2014.The study aims : 1. Health care evaluation in neonatal intensive care units of maternity wards in Baghdad hospitals in terms of input (human and non - human resources) and outcome.2. Identifying causes of admissions and causes of deaths occurring in neonatal intensive care units The study consisted of two parts : A structure evaluation is using a check list to assess availability of human and non - human resources, covering infrastructure, manpower, equipment, and supplies; and an outcome evaluation study using hospital registration records review for causes of admission and causes of death in neonatal intensive care units during the year 2013.It was found that the mean number of specialist doctors in neonatal intensive care units was 2.1 and with standard deviation ±1.3, and college nurse was 2.2, with standard deviation of ±4.004, pharmacist was 0.4 with standard deviation of± 0.516 and for supplementary staff 1.5 with standard deviation of± 0.516.More than half 54% of nurses had no training in neonatal care.Concerning the availability of general equipment it was adequate except for computers 40%.Air conditioning, lighting and windows in addition to safe water supply was good 100% but ventilation was poor 67%, hand washing area was not always present 60% and free elbow operated water tubes were available in 6.7%. Availability of neonatal intensive care units special area was adequate for storage area 85.7% gowning area78.6%, while all the remaining areas were poorly available (resting room, examining room, mother room, boiling and autoclave room, area for mixing intravenous fluid and medication).Neonatal intensive care units were narrow and area/incubator ranging from 2.28m2 to 4.36m2/ incubator. Number of incubators was 246 with patient/ incubator ratio 53.6 : 1 and 27% of Neonatal intensive care units had no regular maintenance for incubators. Large Neonatal intensive care units >25 incubators were overcrowded, having below standards area/incubator, incubators covers only two third of neonatal care. Still up to one third of Neonatal intensive care units are getting their oxygen supply by cylinders, not pipes. Most equipment for individual use were poorly available. Most of Neonatal intensive care units emergency (cupboard) drugs and supplies were sufficiently available round the clock. Total admissions to Neonatal intensive care units were 13195 neonates. Male neonate's admissions 60% were higher than females 40%. Main causes of admission were Respiratory distress syndrome 43%, prematurity and low birth weight 19.4%, and Transient tachypnea 17.4%; birth asphyxia 4%, and hypoglycemia 3.8%, Congenital anomalies 3.7%, Neonatal jaundice 3%, while meconium aspiration and septicemia were the lowest1%. From all these admissions 74% were discharged well, (6%) were referred, while those discharged against medical advice were (4%) and the rest (16%) died. The main causes of death in Neonatal intensive care units were Respiratory distress syndrome 34%, prematurity and low birth weight 31% congenital anomalies 12%, birth asphyxia 8%, septicemia 4%, meconium aspiration 1% and 10% due to other unclassified causes. From this evaluation study, it can be concluded that there were Neonatal intensive care units with under staffing, undertraining and poor designing. Respiratory distress syndrome and prematurity were the main neonatal health problems.

تاثير عقار الميتفورمين, الكاناكلفلوزين او اجتماعهما معا على بعض المؤشرات الكيميائيه في الفئران ذوات السمنه المحدثه == Effect Of Metformin, Canagliflozin & Their Combination On Certain Biochemical Parameters In Diet Induced Obese Mice

اسم المؤلف: اسماء عبد الوهاب احمد
اسم المشرف: علي اسماعيل عبد الله محمد | خالد جمعه خليل
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعرف السمنه ب ترسب الدهون وخاصه في منطقه البطن الذي يرتبط ارتباطا وثيقا بالنظام الغذئي الناجم عن مرض خطير مثل السكري , اضطراب الدهون في الدم وارتفاع ضغط الدم التي توثر على صحه الانسان. ميتفورمين له تاثير ايجابي على التغيرات الايضيه الناتجه عن السمنه. علا | Background : Obesity is defined as the deposition of fat, especially in abdominal regions, which is closely related to serious diet - induced diseases such as type2 diabetes, dyslipidemia, and hypertension that affect human health. metformin has favorable influence on metabolic changes induced by obesity. Furthermore; treatment with metformin has good hepatoprotective effects against fatty changes induced by high fat diet. Moreover, it's interesting to mention that canagliflozin has comparable therapeutic effects to metformin on obesity induced metabolic disturbance but, unfortunately, it has not significant therapeutic impact on obesity induced hepatic steatosis. Interestingly, it has been found in the present study that use of metformin and canagliflozin in combination has superior promising impact on obesity induced metabolic and pathological changes.Aim of the study : The present study investigated the influence of metformin, canagliflozin, & their combination on body weight, food intake, glycemic indices, insulin sensitivity, and lipid profiles in diet - induced obese mice Materials and methods : The animals were divided into two groups.The first group feed with normal chow served as normal group {n=10}. The second group feed with high fat diet serve as high fat diet group {n=40} for two and half months and after the induction of obesity, then further subdivides into four groups. Group I : still feed with normal chow serve as control group{n=10}. Group II : received no drug(s) but only feeding with high fat diet, which serves as high fat diet group{n=10}. Group III : received a single dose of canagliflozin {10 mg/kg/po}, daily for 4 weeks by gavage method serves as canagliflozin group{n=10}. Group IV : received single dose of metformin {300 mg/ kg, po}, daily for 4 weeks by gavage method serves as metformin group{n=10}. Group V : received single dose of both canagliflozin {10mg/ kg, po} and metformin{300mg/kg, po}, daily for 4 weeks by gavage method serves as combination group{n=10}.At the end of the study, blood samples were taken for biochemical analysis, then animals were sacrificed and livers were taken for histopathological examination. Results : Mice feeding with high fat calorie content 60% for two and half months showed a significant increase in body weight, food intake, glycemic indices, homeostasis model assessment - insulin resistance (HOMA - IR), fasting plasma insulin and lipid profiles with important histopathological alterations. While, treatment with metformin - canagliflozin combination elicited a significant decrease in the all study and biochemical parameters with significant histopathological changes characterized by complete improvement on hepatic tissues. In comparison to metformin treatment also showed significant decrease in all study & biochemical parameters with good protective effect against obesity - induced hepatic steotosis. Whereas, canagliflozin also showed a significant decrease in all study and biochemical parameters with no significant improvement on hepatic tissue but the main thing that observed with canagliflozin is a superior effect on body weight with respect to metformin.Conclusion : treatment with metformin - canagliflozin combination provides a significant hepatoprotective effects against fatty changes induced by high fat diet. Moreover, this combination has favorable influence on metabolic changes induced by obesity. Whereas, each drugs alone show good improvement on many parameters including body weight, glycemic indices, insulin sensitivity, and lipid profiles with better improvement of hepatic tissue associated with metformin in contrast to canagliflozin that shows no significant improvement in hepatic tissue but, the excellent reduction in body weight seen in canagliflozin with respect to metformin.

استهلاك الجسم للاوكسجين اثناء عملية التروية القلبية - الرئوية باستخدام ماكنة القلب والرئة الصناعية عند درجات الحرارة الاعتيادية والمنخفضة == Correction Of QT, QTp, And Tpte Intervals To Heart Rate

اسم المؤلف: همام عبد الرحمن ابراهيم العبيدي
اسم المشرف: نبا عبد اللطيف رشيد ناجي | احمد عبودي نعمة المحمودي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفيزياء الطبية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: This study was conducted in pursuit of gaining a better understanding of the importance of hypothermia for cardiac surgery, and for CABG in particular. Most of the cardiac surgeons worldwide are accustomed to the use of mild hypothermia (32 - 35)°C for CABG procedures. Studies showed however that the risks of exposing the patient to mild hypothermia are similar to the risks endured during moderate hypothermia (28 - 32)°C. Objectives This study sought to weigh the benefits of mild hypothermia and moderate hypothermia against that of normothermia (35 - 37)°C concerning their impact on tissue oxygen consumption. Design This study is Prospective, randomized, comparative and purely observational and does not involve any intervention to the patient beyond the standard normal management. Setting At the department of physiology, college of medicine, Al - Mustansiriyah university in cooperation with the Iraqi Center for Heart Diseases and Ibn Al - Bitar Specialized Cardiac Surgery Center, in Baghdad, between December 2014 and April 2015. Patients, materials and methods Seventy patients, (55) males and (15) females, undergoing coronary artery bypass grafting surgery (CABG) were included in this study. Patients were allocated into three groups according to the surgeon's preferences; viz (normothermia, mild hypothermia and moderate hypothermia). Systemic complications associated with hypothermia were investigated via chemical analysis of the blood samples for renal and liver functions. Blood samples were collected two times during CPB from the arterial and venous ports of the oxygenator and were immediately analyzed to determine oxygen consumption and oxygen delivery. Results The decrease in the temperature for the hypothermic groups showed similar values of oxygen delivery (DO2) to that of normothermia (3537)°C at the same period during CPB. There were no noticeable changes between normothermia and mild hypothermia (32 - 35)°C. However, for moderate hypothermia (28 - 32)°C, there was a remarkable decrease in the oxygen consumption (VO2). The biochemical analysis for renal and liver functions in the normothermia and moderate hypothermia groups showed no significant differences between preoperative and postoperative results. However, in the group with mild hypothermia there was a significant change in results. Conclusion Moderate hypothermia rather than mild hypothermia proves to be of more benefit to the tissues when compared to normothermic conditions, as it significantly reduces tissue oxygen consumption. Moreover, even normothermia was found to be superior to mild hypothermia due to the latter's adverse effects on renal and liver functions while it maintains similar results with regards to oxygen consumption.

Immunological Status Of Seminal Plasma For Bodybuilders On Androgenic Anabolic Steroid Hormones == Immunological Status Of Seminal Plasma For Bodybuilders On Androgenic Anabolic Steroid Hormones

اسم المؤلف: Anwar M. Rasheed Abdulhussein
اسم المشرف: Dr.Abduladheem Y. Abbood AL.Barra
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الطب
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Exercises done by bodybuilder have great benefit for the general health and muscle size and performance. Anabolic androgenic steroid hormones are commonly used by bodybuilders to increase muscle mass and strength depending on its mode of action to increase the level of nitrogen retention in muscle, insulin like growth factor IGF - 1 increase in muscle tissue and seminal fluid. IGF - 1 responsible for Cell proliferation, growth and inhibiting apoptosis activity. Also AAS generally has an immunmodulatory impact on cytokines interactions as well as infertility. This study was designed to estimate the changes in cytokines in seminal plasma, sperm count in the seminal fluid and estimation of testosterone concentration in serum due to the impact of androgenic anabolic steroids hormones in bodybuildrs. Eighty male volunteers their age groups are ranging from 21 - 35 years. They were divided into three groups; the first group 27 age matched volunteers apparently healthy (healthy control group) , Second group 27 bodybuilders players attending the sport club with androgen anabolic steroid hormone abuse (AAS) (steroid group), and the third group 26 bodybuilder players attending this sport club in Baghdad without AAS uptake (fitness group ). A blood sample and seminal fluid were obtained from each individual involved in this study. Blood, serum and seminal plasma were prepared from these samples were obtained and applied for estimation of testosterone level by using enzyme immuno - florescent technology. Anti - sperm Ab test by heamo - aglutenation method was used to exclude the positive cases from this study.Heparinized blood was used for estimation of neutrophil phagocytic activity Sperm count was done for each seminal fluid sample, cytokines were estimated by sandwich ELISA method, in seminal plasma, these cytokines are IL - 6, IL - 10,IL17a,TNF - ? and INF - ?. The bodybuilders with AAS uptake showed a significant reduction in sperm count (P=0.00), fitness group sperm count showed slight nonsignificant decrease compared to healthy control group (P=0.7). Serum testosterone level in the AAS uptake group showed a significant decline compared with fitness and healthy control groups (P= 0.00). Exercise alone increases the level of IL - 6 (P=0.00), while exercise with AAS uptake decreases the level of IL - 6 (P=0.06). The fitness group showed highly significant increases in TNF alpha (P =0. 00). IL - 10 as an anti - inflammatory cytokine shows a high level in the AAS uptake group compared to the healthy group (0.04). IL - 17 as an inflammatory cytokine showed high significant increase in steroid group and fitness group (P=0.00), which indicate that both exercises with and without AAS uptake increases the level of IL - 17 secretion(P= 0.02) separately or in combination. Phagocytosis of AAS uptake group showed a highly significant decline (P= 0.00).The correlation results showed that there is a complex network interactions between the studied cytokines. The Phagocytic activity of the AAS uptake group showed a strong correlation with both IL - 6 and IL - 10 levels. IL - 10 as a suppresser cytokine has a significant correlation with TNF - alpha, INF - gamma and IL - 17A while, IL - 10 showed a negative correlation with IL - 6. IL - 17 which act as an inflammatory cytokine has a significant correlation with all cytokines except IL6 and phagocytic activity. Generally seminal plasma cytokine network may be under the effect of immune regulation mechanism and cytokine inactions as well as, the impact of steroids uptakes. In general the final impact of AAS uptake on bodybuilders immunity are declining in phagocytosis and an increase in IL - 10 which act as suppressor to the Th1 immune response and increase of IL - 17 which has a role in increasing the inflammatory response so, these results suggest that AAS abuse players may be more liable for infection and decrease in sperm count which may cause temporary or permanent infertility.

دراسة المقاومة المتعددة للمضادات الحيوية لعصيات التدرن لدى مرضى التدرن الرئوي == A Study On Drug Resistance Of Mycobacterium Tuberculosis Isolated From Pulmonary Tuberculosis Patients

اسم المؤلف: انمار ليث طالب الحسني
اسم المشرف: عامر رشيد النجار | احمد اسمر منخي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعتبر عزلات جراثيم التدرن المقاومه للادوية من المشاكل الرئيسية في معالجة مرضى التدرن حول العالم. , ولاهميته اجريت هذه الدراسة لتسليط الضوء اكثر حول الحساسيه الدوائية بواسطة الطرق المختبرية التقليدية وعلى الوسط الصلب ومقارنته مع الطرق التشخيصية المختبرية ا | Drug resistant tuberculosis remained as major problems in the treatment of tuberculosis patients in the world. A prospective study was conducted to evaluate drug susceptibility testing (DST) by classical methods on solid media as compared with advance and molecular Laboratory diagnostic methods (Bactec MGIT 960 and GeneXpert MTB - RIF ). The study included the estimation of the first line anti - TB drugs, including (Rifampicin,Isonizid,Streptomycin and Etambutol) by solid media (Lowenstein - Jensen medium) and Bactec MGIT 960 system. In addition, the use of rapid molecular diagnostic method by GeneXpert MTB/RIF assay. Seventy five TB patients attending the National Reference Laboratory of Tuberculosis /medical city - Baghdad from December 2015 to June 2016 were included in this study. Patients were classified into two main groups : selected MDR patients, which were referred from different hospitals and health respiratory center in Iraq, represented 46 in order to compare different laboratory methods to detect of DST isolates, while 29 were randomly isolated and identified , the study matched by age and gender were also included. This study revealed that the drug resistance tuberculosis to Rifampicin was 47 (62.7%), Isonizid 41 (54.7%), Streptomycin 42 (56.0%) and Ethambutol 38 (50.7%). Respectively , on the golden stander in which solid media were used.The molecular and advance technique (GeneXpert and Bactec MGIT 960) as applied to estimation of drug resistance tuberculosis, the results of drug susceptibility testing (DST), as showed highly sensitivity and Accuracy, when compared with golden stander( LJ media) especially in detected of primary drugs (Rifampicin and Isoniazid) and showed lower sensitivity and accuracy to detected of the secondary drugs (Streptomycin and Ethambutol). The Multiple drug resistance (MDR - TB) case from selective samples was found to be almost similar to that found in other countries of the middle east and other regions in the world. While in the randomly identified samples, the rate of MDR - TB was lower than the referred (previously treated) cases.The GeneXpert MTB - RIF system is rapid molecular methods that used in many countries to identify of MTB and Rifampicin detected during 2 hours only, that used in this study. The high Rifampicin resistance and other drugs of local isolates could be due to abuse of the drug,defaulter and relapse of retreating cases (previously treated).

الكشف عن طفر الجين عامل النمو البشراوي الثاني (HER2) في سرطان الخلايا الانتقالية باستعمال طريقة اللونية في موقع التهجين == The Detection Of HER2 Gene Mutation In Transitional Cell Carcinoma Using CISH Method

اسم المؤلف: عمار عيسى مهدي
اسم المشرف: احمد تركي عبيد | هادي محمد علي الموسوي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الامراض السريرية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يعتبر سرطان المثانة واحدا من اكثر انواع الاورام السرطانية التي تصيب الجهاز البولي حيث انه يعتبر ثاني ورابع الاكثر شيوعا للذكور في العراق والولايات المتحدة على التوالي وايضا يعتبر العاشر والحادي الاكثر شيوعا للاناث في العراق والولايات المتحدة على التوالي. | The urinary bladder cancers are among the common types of cancer of the urinary tract. It is regarded as the second and the fourth most common cancer types for males in Iraq and in the United State of America (USA) respectively and as tenth and eleventh most common cancer types for females in both Iraq and USA respectively. Urothelial Carcinoma is epithelial tumor of urinary bladder (95% of urinary bladder tumor) and it shows wide range of tumor that begins from papilloma and carcinoma in situ to invasive cancer. The patients with urinary bladder cancer that are presented in non - muscle invasive type or muscle invasive type show different rates of HER2 gene amplification (specially for invasive muscle type). Epidermal growth factor receptor (EGFR, also called HER or type I ErbB tyrosine kinase receptors) family is composed of four receptor member which include HER1 (ErbB1 or EGFR), HER2/neu (ErbB2 or C - ErbB2) , ErbB3 ( HER3), and ErbB4 (HER4). HER2/neu protein is glycoprotein produced by HER2 gene which lies in 17q21 (long arm of chromosome 17). This glycoprotein is normally found in lung, breast, urinary bladder, prostate and stomach, and its cytoplasmic portion has enzymatic function (tyrosine kinase activity). This receptor is responsible for the cell survival, normal cell growing and inhibition of apoptosis. HER2/neu protein overexpression is measured by IHC when the result of IHC is equivocal to HER2/neu protein (+ 2). Then, HER2 gene amplification is measured by using an accurate and more practical CISH method. The aims of this study are tried to detect the percentage of HER2 gene amplification in the urothelial carcinoma and distribution of HER2 gene amplification with clinical criteria (age , sex, grade, stage, and location of tumor) of the patients that had urothelial carcinoma of bladder.This study contained retrospective (30 cases) and prospective (20 cases) and was conducted in Al - Hilla Surgical Teaching Hospital and the period of the study extended from October /2015 to August/2016. Clinical data of patients include age, gender , clinical features, and type of bladder biopsy ( endoscopic resection or cystectomy) are taken with paraffin blocks.The practical part of the study was done in the laboratory of the department of pathology / College of Medicine/Babylon university. It included 50 patients with bladder cancer (35 males and 15 females ) with two groups (10 cases is positive and 10 cases is negative). It included 50 patients who were diagnosed with transitional cell carcinoma of urinary bladder with mean age ± SD ( 66.04 ± 10.148 ) years old ranging between 42 - 83 years old. Also, Positive and negative control slides applied with each run CISH method (+ve control of breast tissue that treated by immnohistochemical procedure ( score +3) and the same tissue were applied by removing HER2/neu probe).Fifty patients who were diagnosed with transitional cell carcinoma of bladder and their biopsies of bladder ( taken from endoscopic biopsy or cystectomy). Then, paraffin - embedding procedure was prepared on tissues biopsy and then, hematoxylin and eosin staining (H. and E. staining) procedure was done. Finally, manual CISH was done on both cases(positive and negative cases) and bladder cancer blocks. This CISH method detected her2 amplification according to ASCO/CAP/2013 scoring system. The results showed that age group 61 - 70 years was the highest positive HER2 amplification (64.7%) among other age groups 51 - 60 years (11.8%) and 71 - 80 years old (23.5%), there was a significant association between these age groups with HER2 amplification , p? 0.05. Sex group displayed that 52.9% of male and 47.1% of female who had positive HER2 amplification and there was no significant difference between sex groups with HER2 amplification, p > 0.05. Other results showed that positive HER2 amplification was highest in grade 3 (88.2%) of transitional cell carcinoma when compared to grade 2 (11.8) and grade 1 (0%) and there was significant association between cancer grading system with HER2 amplification, p? 0.05. MIBC and NMIBC of staging cancer system showed 82.4% and 17.6% positive HER2 amplification respectively with a significant difference between them ( p value ? 0.05). Also, other result of the histological types of transitional cell carcinoma revealed 88.2% and 11.8% (positive HER2 amplification) of papillary and flat shape respectively with a significant correlation between them ( p value ? 0.05). The HER2 gene amplification was correlated with grade and stage of bladder carcinoma which showed high amplification in high grade and stage. The HER2 gene amplification was not correlated with the sex of the patients, but more cases of HER2 gene amplification were recorded in males; while there was a correlation with age group specifically (61 - 70 years old). The HER2 gene amplification was associated with aggressive behavior of blabber carcinoma. The CISH method application in HER2 gene amplification was flexible and applical.

التوصيف الجزيئي لعوامل الضراوة المرتبطة باصابات بكتريا المكورات العنقودية السالبة للتخثير والمعزولة من المصابين بالتهاب المجاري البولية في محافظة بابل == Molecular Characterization Of Some Virulence Associated Factors For Coagulase - Negative Staphylococci Isolated From Urinary Tract Infection In Babylon Province

اسم المؤلف: سارة هاشم داخل الحلي
اسم المشرف: محمد صبري عبد الرزاق السعيد | جواد كاظم الخفاجي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يهدف هذا البحث الى دراسة بكتريا المكورات العنقودية السلبية التخثر, وشملت الدراسة جمع120 عينة ادرار من المرضى المصابين بالتهاب المجاري البولية من الاشخاص المراجعين والراقدين في مستشفى بابل للنسائية والاطفال ومستشفى الحلة التعليمي وللفترة من كانون الاول 201 | This work aims to study coagulase - negative Staphylococci, which included 120 urine sample were obtained from patients suffering from urinary tract infection; who attained to Babylon Maternity and Pediatrics Hospital, and Al - Hilla General Teaching Hospital, during the period from December 2015 to March 2016), they were diagnosed as having UTI by the Urologists. The samples were analyzed for any signs of infection and immediately inoculated on blood and MacConkey agar media plates. All plates were incubated aerobically at 37 ?C for 24 - 48 hrs.Results of morphological and biochemical characterization revealed that out of total of 120 urine samples, 110 showed positive culture, among them 37 isolates are belonged to coagulase - negative Staphylococci, other 73 isolates belonged to other bacterial genera.Molecular detection of coagulase gene (coa) was done for all CoNS isolates. The results showed that 28/37 isolates (75.67%) were positive for this marker, distributed as follows : S. epidermidis gave 15 isolates, S. saprophyticus gave 9 isolates and S. haemolyticus gave 4 isolates.Also, molecular investigation of fnb A and B genes are carried out for all CoNS isolates by using specific PCR markers. 13/37 isolates (35%) were positive for fnb A gene, as 6/13 of S. epidermidis, 5/13 of S.saprophyticus and 2/13 of S. haemolyticus have this gene in their genome. On the other hand, only 4/37 isolates gave positive result for fnb B gene; as 2 isolates of both S. saprophyticus and S. epidermidis have this gene in their genome.Moreover, sec gene also was investigated in CoNS isolates. The results showed that all CoNS isolates are free from this gene.Regarding urease enzyme production, S. epidermidis and S.saprophyticus isolates were found to be urease positive, while S.haemolyticus isolates display urease negative.To demonstrate the ability of bacteria to form struvite stone, urine samples obtained from healthy individuals were used. It was found that struvite stone was formed by S. epidermidis and S. saprophyticus isolates.Moreover, susceptibility to 10 antibiotics were tested by using disc diffusion test (DDT). S. epidermidis was showed 100% resistance for each Methicilline, Ceftriaxone, Ceftazidime and Cefoxitin. Also, it show high resistance 94%, 88%, 88%, 76%, and 59% for Impenem, Gentamycin, Pipracillin, Ciprofloxacin and Amikacin respectively. However, S. epidermidis showed low resistance (6%) for Vancomycin. So, all S. saprophyticus isolates showed high resistance (100%) to each Pipracilline, Ceftriaxone, Methicillin, Ceftazidime and Ciprofloxacin. It showed high resistance (92%) for each Vancomycin and Imipenem, and (83%), (75%), (75%) for Cefoxitin, Gentamycin and Amikacin respectively. In addition to that, all S. haemolyticus was showed (100%) resistance for each Ceftriaxone, Pipracillin, Methicilline, Ceftazidime and Cefoxitin. Also, showed high resistance (75%), (63%) and (50%) for Gentamycin, Amikacin and Ciprofloxacin respectively. While it was showed low resistance (13%) to Vancomycin.

الصورة البكتيرية والنسيجية المرافقة لالتهاب اللوزتين المزمن والادينويد عند الاطفال == Bacteriological And Histopathological Profile Associated With Chronic Tonsillitis And Adenoid Hypertrophy In Children

اسم المؤلف: رشا محسن كاظم الحسيني
اسم المشرف: حبيب صاحب نهر | صفاء حسين الطريحي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: This study aimed to investigate the bacterial profile of surface and core of infected tonsils and adenoid tissues and histopathological examination of these organs.A total of 122 samples represented by 63 excised tonsils and 59 excised adenoids in addition to 57 blood samples were collected from 70 patients who were referred to Hilla Teaching Hospital (Ear, Nose and Throat unit) in Hilla city within a period of four months from November 2015 to February 2016. Those patients weresuffering from chronic tonsillitis and adenoid hypertrophy. The ages of those patients ranged from 2 to 15 years, 41 (59%) of them were males and 29 (41%) were females.The study included three main parts. The first one was the bacterial diagnosis based on relied diagnostic procedures. Second part was the detection of antistreptolysin O (ASO) by using latex agglutination test, while the third part included histopathological study to detect the pathological lesions that occur during these infections.The results indicated that, the most age group being susceptible for chronic tonsillitis and adenoid hypertrophy was the group of 7 - 10 years, represented 33 patients with a percentage of (47%). Among this group, males were more susceptible with percentage of 20 (29%) compared to female patients13 (19%).The surface of all samples (tonsil and adenoid) revealed positive results for bacterial culture, while in the core of tonsil only 44 samples (70%) were positive for bacterial culture while 19 samples (30%) were negative results (no growth). As in tonsils, the core of adenoid revealed positive results in 32 (54%) samples, while 27 (46%) samples were negative results.The suspected isolates were fully identified by using bacteriological, biochemical and Vitek 2 techniques (for two isolates because of those isolates give variable biochemical test results which confused their diagnosis that lead to using of vitek system technique to diagnosis them, these isolates were rare bacteria that infect tonsil and adenoid). The most common types of bacterial isolates were Staphylococcus aureus which accounted for 75 isolates (23.6%), followed by Streptococcus pyogenes 61isolates (19%), Escherichia coli 57 isolates (18%), Klebsiellae pneumoniae 55 isolates (17.3%), Hemophilus influenza 37 isolates (11.6%), Sphingomonas paucimobilis 14 isolates (4.4%), Staphylococcus epidermides 7 isolates (2.2%), Pseudomonas aeruginosae 6 isolates (2%), Pseudomonas stutzeri 5 isolates (1.6%), and Staphylococcus saprophyticus only one isolate (0.3%).Regarding the bacterial population, there is a difference between tonsils / adenoid surface and tonsil/ adenoid core culture were the most predominant isolate from tonsil surface was Staphylococcus aureus and K. pneumoniae from tonsillar core, while from adenoid surface was Streptococcus pyogenes whereas E. coli from adenoid core.The ASO titer in patients with or without group A streptococcal infections were determined by using latex agglutination test. The results revealed that 8 samples (14%) exhibited positive results, while 49 samples (86%) exhibited negative results out of 57 samples. The results showed statistically no significant differences between patient age groups but showed highly significant differences between males and females.Eight specimens were taking for histopathological examination randomly, four samples were adenoids and four samples were tonsils. The histopathology examination of tonsil and adenoid showed the presence of lymphoid hyperplasia,multiple lymphoid follicles, vascular congestion, fibrosis, germinal centers, infiltration of inflammatory cells, necrosis and apoptosis of tissues

تقييم المؤشرات السريرية وبعض الدلائل الحيوية في مرض دواعم الاسنان == Evaluation Of Clinical Parameters And Some Biomarkers In Periodontal Disease

اسم المؤلف: امل عليوي حسن
اسم المشرف: سعد مرزة حسين الاعرجي | وسام وهاب الحمادي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: امراض دواعم الاسنان هي مجموعة من امراض الالتهابات التي تصيب التجويف الفموي وتعرض الهياكل الداعمة للاسنان للخطر. تحدث هذه الامراض بسبب عدم التوازن بين الجراثيم المحيطة بالاسنان واستجابة المضيف. يعتبر مرض التهاب اللثة ومرض النساغ المزمن هي من الاقسام الرئيس | Periodontal diseases are a group of inflammatory diseases that affect the oral cavity and jeopardize the supporting structures of teeth. They are caused by an imbalance between periodontal pathogens and host responses. Gingivitis and chronic periodontitis are the major categories of these diseases. The study sample consisted of 80 individual of both genders, their age ranged from 30 to 50 years, and they are divided into three main groups according to the clinical periodontal parameters (plaque index, gingival index, bleeding on probing index, probing pocket depth index and clinical attachment level index). Group ? comprised from 24 (15 female and 9 male) healthy gingival volunteers as a control, group ?? comprised from of 29 (12 female and 17 male) patients with gingivitis, lastly group ??? comprised from 27 (11 female and 16 male) patients with chronic periodontitis. Unstimulated whole saliva samples are collected to determine the levels of Prostaglandin E2, Matrix Metalloprotinase - 8 and Alkaline Phosphatase. Clinical periodontal parameters are recorded at four sites per tooth. The results of present study revealed a highly significant difference (P - value < 0.01) in the mean ± SD for all of clinical periodontal parameters and for the levels of salivary biomarkers (Prostaglandin E2, Matrix Metalloproteinasee - 8 and Alkaline Phosphatase) among chronic periodontitis, gingivitis and control groups. The chronic periodontitis group revealed the higher mean value followed by the gingivitis group and the control group presented the least value. Regarding the correlation between the salivary biomarkers levels and clinical periodontal parameters, the present study showed a significant positive correlation (P< 0.05) and a highly significant positive correlation (P - value < 0.01) between each of salivary biomarker levels and all of clinical periodontal parameters. In addition, this study showed a highly significant positive correlation (P - value < 0.01) between Prostaglandin E2 and Matrix Metalloproteinasee - 8 and a significant positive correlation (P< 0.05) between Prostaglandin E2 and Alkaline Phosphatase and between Matrix Metalloproteinasee - 8 and Alkaline Phosphatase for gingivitis and chronic periodontitis groups. The present study re - emphasized the importance of whole saliva as sampling method in relations of immunological purposes in gingivitis and chronic periodontitis and proposed that the elevated levels of Prostaglandin E2, Matrix Metalloproteinasee - 8 and Alkaline Phosphatase may be one of the host - response mechanisms connect with the clinical appearances of periodontal diseases. Salivary Prostaglandin E2, Matrix Metalloproteinasee - 8 and Alkaline Phosphatase levels may reflected the severity of disease, thus help in the early detection of the disease.

تاثير احمرار الدم الثانوي الدم على وظيفة بطانة الاوعية الدموية الجهازية في محافظة بابل == Effect Of Secondary Polycythemia On Systemic Endothelial Function In Babylon Province

اسم المؤلف: احمد محي الدين سهراب
اسم المشرف: غافل صيهود حسن الشجيري | عامر صاحب المؤمن
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: تغير قطر الشريان العضدي كاستجابة الى الاحتقان , يستعمل بصورة واسعة لتقيم وظيفة بطانة الاوعية الدموية الجهازية بواسطة تسجيل التغير كاستجابة للاحتقان. ضعف او قلة التوسع يلاحظ بصورة واضحة لدى المرضى المصابون باحمرار الدم الثانوي.التوسع المحدث بالمد يقاس كن | Brachial artery diameter variations in response to hyperemia were widely used for the assess endothelial function by recording variations in response to hyperemia. Vasodilation was markedly impaired in polycythemic patients.Flow mediated dilatation (FMD) was measured as the percentage increase in brachial artery diameter at diastole after 5 minute of ischemia.Objectives : Material and MethodsThe present study was conducted at Echo - Doppler department in Marjan medical city / Hilla , in cooperation with the department of physiology of College of medicine / University of Babylon, from November 2015 to April 2016. A history, physical examination, blood pressure, and laboratory were performed on all subjects (patients with secondary polycythemia, and control groups). Seventy subjects were included in the present study. Their ages was ranged between 40 - 60 years. They were divided into two groups. Group 1 : Included 30 healthy subjects without polycythemia, all men, their mean age was 47.20 ± 7.3 years and they served as control group.Group 2 : Included 40 patients, all men, with secondary polycythemia, their mean age 46.90 ± 7.3 years.Method : Measurement of flow - mediated and nitroglycerin - induced dilatation of the brachial artery.Measuring blood pressure, auscultatory method.Assessment of BMI.Laboratory analyses : Serum urea test.Serum creatinin test.White blood cells (WBCs) count : Platelets count.Estimation of packed cell volume (PCV %).Red blood cells (RBCs) count. Hb. level test.Cholesterol test.Triglyceride test.Urea test.Creatinine test.Results : The mean flow mediated dilatation (FMD) on two groups was significantly (p value < 0.01) decreased (16%) in patients group (8%) comparison to control group (24%). The mean Hb concentration was significantly (P value < 0.01) increased in patients group compared to control group.The mean packed cell volume (PCV) was significantly (P vale < 0.01) increased in patients group compared to control group.The mean FMD was found to be significantly (16%) decreased in smoker patients group (8%) compared to nonsmoker control group (24 %).The mean red blood cells count was significantly (P value < 0.01) increased in patients group compared to control group.It was found that triglyceride level significantly increased (P value < 0.01) in patients group compared to control group.There was negative correlation between triglyceride and FMD in patients group. Their are No correlation between age and FMD in patients group.The mean serum cholesterol level was not significantly ( p value < 0.07) increased in patients group compared to control group , while serum triglyceride level, serum creatinin, serum urea were significantly ( p value < 0.01) increased respect in patients comparison to control. Mean glucose, Platelets and red blood cells counts were significantly (P value < 0.01) increased in patients group (polycythemic group) respectively compare to control group respectively.Mean body mass index (BMI) and packed cell volume (PCV) were significant (P value < 0.01) increased respectively in patients group compared to control group. Ages of patients group was non - significantly (P value = 0.89) decreased (46.90 ± 7.00 years) in patients group compare to control group.Conclusions : 1 - The mean flow mediated dilatation (FMD) was significantly decreased (16%) in patients group compared to control group. 2 - The mean Hb concentration , mean packed cell volume (PCV) , red blood cells count, platelets , and body mass index count was significantly increased in patients group compared to control group.3 - Polycythemia as with endothelial dysfunctions that may perform in diagnosis of arterial disease. That used to estimate whereas endothelial dysfunctions result from problem in the cardiovascular system with problem in the prothrombin time.4 - Polycythemia can result in raises causes of thrombosis.Through increase platelet dysfunctions, increase ; white blood cell counts, Hb count, homocystein and cholesterol level as with endothelial dysfunctions.

مظاهر العنف الاسري في رسوم المراهقات == Appearances Of Domestic Violence In Teenage Graphics

اسم المؤلف: شيماء مهدي وادي الجنابي
اسم المشرف: هدى هاشم محمد الربيعي
الموضوع العام: الفنون الجميلة
السنة: 2016
الموضوع الدقيق: الفنون التشكيلية
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: حظيت ظاهرة العنف الاسري باهتمام العديد من الدراسات، كون الاسرة المصدر الاول للثقافات واقوى الجماعات في التاثير في سلوك الابناء، فهي من اهم عوامل التنشئة والتطبيع الاجتماعي فالاساليب التي يستخدمها الابوان في معاملة ابنائهم كالاهمال والقسوة والتفرقة واستخدا | The phenomenon of the domestic violence meets high attention in many studies , as the family is the first resource of cultures and the it is the strongest group in affecting the behavior of children , also it is the most important factor of nurturing and social customization.. Methods of parents in treating with children , by neglecting, hardness , segregation, the use of swear words , deferent kinds of beating and any other type of bad methods which come within violence actions ((psychologically , physically and verbally)) , all these methods could leave negative impact in the souls of children , especially during earlier adolescence as it is the most dangerous age stage of the individual life, due to what it carries in its folds of conflicts and psychological disorders and changes in all physical, mental and emotional aspects.. Girls in this stage may suffer their families practices of violence against them , so the intensity of female sensitivity to problems could form psychological pressures which could make her a troubled personality teenager who lacking self confidence, isolated from others and with reluctant behavior, also for far future she may have an aggressiveness and violent motives.. Since the arts generally and graphics arts in particular have a role to alleviate the suffering of human , they assist to achieve the emotional equilibrium and allow the self - expression and emotions as well as they achieve the inner harmony and poise of personality in relationships with others , so this factor allowed the researcher to answer about following question : Does the domestic violence have appearances that could be reflected in graphics of teenage girls through lines , shapes and colors ? Could the graphics be equal with the pronounced language in guidance to the meanings , transferring the ideas and hardships and to be connected to others ? So the current research had aimed to the following : 1. Exposing the types of domestic violence which is addressed to teenage girls.2. Exposing the appearances of domestic violence in graphics of teenage girls through graphics properties , then the research importance and the need to it , in addition to research outlines and abbreviations, those come the first chapter of the research.. The second chapter includes the theoretical framework and the previous studies , as the research is consisted of two studies , the researcher in the first one is addressed to the conception of the domestic violence, in which she included many sections , but the second one is addressed to the adolescence and graphics of adolescents , while the previous studies included 5 ones and were about the domestic violence and the graphics of adolescents. The third chapter included the research arrangements ((society of the research , its approach and samples of 330 pupil of second intermediate class who were divided randomly to 9 intermediate schools and high schools in the center of Babylon province. The research needed to use two ways to measure the violence degree , the "Fartoosi" scale which was prepared to measure violence of pupils of high schools , and was amended to be proper with the samples of the current research , then checked its credibility and stability , as it was showed to some experts and specialists in the psychology field , but the second way was about analyzing the graphics of the teenage girls which was formed by researcher in depending upon literatures of specialists , the previous studies , indications of the theoretical framework, notes of graphics of teenage girls and the modest experience of the researcher , also it was showed to some experts and specialists of the arts education , Fine arts psychology fields to check the credibility and the capability to analyze the graphics , in addition to a couple of statistical methods which are proper and suit the purposes of the current research. The fourth chapter includes the results and their interpretations that the researcher reached to , in addition to their conclusions, recommendations and suggestions, the results of the research revealed a higher ratio of psychological violence beside the verbal violence and the physical violence.. Also the domestic violence has specific appearances in the graphics of teenage girls (the upper faction) which were represented in 16 traits , and unspecific appearances of domestic violence in graphics of teenage girls (the lower faction) which were represented in 19 traits , there were also 6 traits of statistical meanings among both factions.. The conclusions clarify that there are 14 traits which are considered as a specific appearances of psychological violence in the graphics of teenage girls (of upper faction) , while there was 1 trait , it was considered as specific appearance of the verbal violence in the graphics of the teenage girls (upper faction).. The recommendations of the research is exposing generally the violence against women (through arts fields - the graphics for example - by specialist educational administrations , including the the intermediate schools and high schools to until reaching the universities to exceed their reasons by educational and scientific methods , as the teenage girl is a project of a future woman.. The research included a number of suggestions with Arabic and English resources and appendixes beside a brief in English language..

الحوارية ومقارباتها الجمالية والدلالية في رسوم بابلو بيكاسو == The Dialogisme And Approaches Beautifulness And Denotation In Portrayals Pablo Picaso

اسم المؤلف: روى ناظم حسن الحسناوي
اسم المشرف: فاطمة لطيف عبد الله الخفاجي
الموضوع العام: الفنون الجميلة
السنة: 2016
الموضوع الدقيق: الفنون التشكيلية
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: تبنت الباحثة موضوعة بحثها الذي بني انطلاقا من مشكلة تتمحور في دراسة ( الحوارية ومقارباتها الجمالية والدلالية في رسوم بابلو بيكاسو ) , وذلك لكون الحوارية مفهوما له ابعاده الجمالية والدلالية التي تظهر من خلال البناء التشكيلي للعمل , لتحقيق التواصل وال | The researcher adopted study built from the basic problem that centered in the study (The Dialogisme and Approaches Beautifulness and Denotation in Portrayals Pablo picaso ). And so as the concept of aesthetic and semantic dimensions to talk shows that appear during the construction of the visual work of art, as it seeks to achieve communication and continuity.The first chapter has included the objective of the study which is detected (talk shows and Mgarbadtha aesthetic and semantic in fees Pablo Picasso) and provided for the period of (1901 - 1946).In the theoretical framework includes five sections, the first section has studying talk shows (conceptually, and principles, and mechanisms), and the second section included two axes, and the first axis finding approach between the talk show concept, aesthetic and cognitive thought, it start from the Greeks and up to the modern philosophers and contemporary of them, while the second axis has cared for studying dialogue structure in the arguments of psychology, and included third section read talk shows critical reading of the status of the dialogue theory, finding points of engagement with the concept of semantics and subtraction semiotic,while Section fourth included the works technically talk and according to its historical development, from primitive art and up to the modern technical schools and is interested in section five (Picasso) art, highlighting the most important stages that make up a key point in the birth of the creative work of the talk show - style and new technology. At the end of the theoretical framework researcher it conducted a comparison between previous studies placed with her research, and also was addressed to the outcome of the indicators.In The third chapter included the community research who cannot promise to capacity size, although informed researcher on a lot of photographers, and sources relevant, such as (books, magazines, sites and the Internet), but it was unable to limit the research community statistically, and the sample Search (13) artworks included oily technique, collage, and the various technical stages undergone by the (Picasso)) The researcher ended his work by using content analysis tool, the coefficient of stability of the tool, and the sincerity of the tool, and then use statistical methods, the equation (Cooper) to calculate the sincerity of the tool, and an equation (Scott scoot) to calculate the stability of the tool. The researcher has adopted the analytical method (hermeneutical) in the sample analysis.The fourth chapter was devoted to reviewing (Results - Conclusions - Recommendations - proposals) as the researcher reviewed the search results, and that was as follow as : 1 - The actually humanly dialogue (self - objectively) do according to the act of dialectic knowledge base side of the artist creator of the artwork, and the receiver, which is an essential part in setting up and continue the dialogue.2 - Dialogue as a kind of freedom from restrictions in the classic art of reading, which does not stop at certain limits, and dialogue interested by flexibility because they coincide with all the Arts and at various schools, including the rules include (philosophical - scientific - stylistic) resound nearly absolute.

اثر دراسة الفن في اتساق الذات لدى طلبة جامعة بابل == The Effect Of Studying Art In The Self - Consistency Of The University Of Babylon Students

اسم المؤلف: بيداء كاظم عليوي الطائي
اسم المشرف: كاظم مرشد ذرب
الموضوع العام: الفنون الجميلة
السنة: 2016
الموضوع الدقيق: الفنون التشكيلية
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يرى الفلاسفة والعلماء والمفكرون والتربويون ان دراسة الفن او ممارسته تسهم او تزيد من بناء شخصية الانسان في جوانبها (المعرفية، والوجدانية، والمهارية ) مما يؤدي الى تحسين سلوك الفرد نحو الافضل الامر الذي تؤكده التربية بشكل عام، ولكن هذه الاراء والطروحات ت | Philosophers and scientists, thinkers and educators believe that studying art or practicing it contributes or increases the building the human character in its aspects (cognitive, emotional, and skill) which leads to improving the individual's behavior for the better, which emphasizes the education in general, but these views and propositions remain within the limits of the assumptions unless it is verified sincerity by scientific research. Hence it identified the problem of current research, which summed up the following question : Do the study of art have an impact of the self - consistency on the students of Babylon UniversityThe Two goals of the research : The current research includes two goals, they are : 1. Build a scale of self - consistency of the University of Babylon Students.2. Detecting the impact of art study in the self - consistency of the students of University of Babylon through the verification of three null hypotheses.Research hypotheses : The research includes the following hypotheses : 1. No impact to the study of art in the self - consistency of the University of Babylon students at the level of significance (0.05).2. No trace of technical specialization variable in the self - consistency of the University of Babylon students at the level of significance (0.05).3. No trace of the sex variable in the self - consistency of the University of Babylon students at the level of significance (0.05)The research community and specimens : Due to the fact that the research methodology in the current study is the descriptive approach (as a scientific comparative study) has required a comparison between a group of studying Art for four years of study, they are fourth - grade students at the Faculty of Fine Arts / University of Babylon and three other groups have not studied art, they are : First grade students at the College of Fine Arts and the fourth grade students in the College of Pharmacy, and fourth - grade students at the Faculty of Law. Total research community in these colleges for the year stood at (2015 - 2016) (957) students, of which 456 males and 501 females. Due to the researcher to build scale of self - consistency, it has required the withdrawal of three samples from the original research community : the reconnaissance sample reached (64) students pulled intentionally, and sample of building a measure amounted to (394) pulled in a random stratified way 50% of the orgional community, to withdraw the basic research sample, the researcher used the percentage way of the remaining the fourth stage male of The Faculty of Fine Arts as the percentage of males (0.53) The percentage of female fourth Faculty of Fine Arts was (0.47), and the total (224) male and female students.Research Tool : The researcher built an objective tool to measure a variable (self - consistency) according to the following steps : 1. Defining the concept of (self - consistency) procedural definition and analyzing its content into four areas : the relationship with others, and uniqueness, work, and gaining knowledge. And drafting (67) items distributed among them.2. Sincerity tool : the researcher used two methods for the sincerity, they are : A - making sense method : Through content analysis or substance which resulted in the deletion of (11) paragraph of the measure after presenting it to the arbitrators, bringing the number of paragraphs (56) items plus four paragraphs to detect objectivity the scale became a paragraph consists of (60)items and after the researcher has checked the sincerity of scale logically, she has put a the Quintet estimation scale of in front of each paragraph and planned a correction key accordingly. Then she has applied it to build a sample to extract the pilot sincerity.B. Pilot method : extracted in three ways : First - Peripheral comparison method between the upper and lower sets.Second - internal consistency method.Third - factor analysis method.3. 3. The stability of the tool : stability of the tool has been achieved in two ways : A method (Cronbach's alpha) : the stability of the scale amounted to (0888).(B) Midterm Fragmination method : the value of the stability of half - scale (744) since this value represents the stability of half scale, so the researcher used the equation (Spearman - Brown) to edit and extract the full value of scale and get a degree of firmness reached (0853), which confirms that the scale has a high degree of constancy and reliable. These measures have resulted in a measure consists of four areas include (45) items and (4) items were added to detect the objectivity, the researcher used the scale of the Quintet estimation in front of each paragraph and prepared correction key accordingly.Application of the tool : after the tool Completed conditions of validity, the researcher applied it to the basic sample of amount (224) students, and after collecting the forms, the researcher corrected it and discharged electronically in accordance with the statistical program (spss), (5) not valid Form were excluded as the respondent did not complete the answer. Add to the exclusion (18) Form where the submitted to the response objectivity and compare it with the spoken class for the absolute differences was larger than the spoken class and thus the form number has become (201) valid forms,they have been statistically analyzed and the results were extracted.Statistical methods : The researcher used the social statistical Pouch (spss) for data processing were used, the Pouc was used in the following topics : 1. Percentage : used by a researcher to unload arbitrators responses, used in the interpretation of the accepted factors and to withdraw the basic sample.2. Mean : Use in substantive response extraction, strength discriminatory clauses. As well as to find Means for computational research samples.3. Standard Deviation : 4. The standard error : 5. Test (T - Test) independent and equal number of samples. To measure the moral significance of the scale paragraphs, which is used to compare Means when samples are big and equal.6. Person Corrlation coefficient)) : To calculate the internal consistency (ratified paragraphs of scale) and to find the relationship between each paragraph of the scale with the total score of the scale, as well as a way to extract the fortitude fragmentation midterm.7. (Sperman Brown Formula) : used to modify the scale and extract the value of the stability of the entire measure, since after measuring the correlation coefficient between the two halves of self - consistency for estimating half of the test, has been modified the mentioned equation.8. Cronbach's alpha formula : to calculate the tool stability.9. Test (F) to calculate the harmony between the two halves of the scale.10. Used in the factorial analysis procedures and find them as follows : - Simple Pearson correlation. - Contrast interpreter. - The underlying root. - Relative importance.11. Unilateral variation analysis of the samples is of equal size : the researcher used it to calculate the significance of differences in general between the three colleges.12. Sheffe Test : The researcher used it to find the smallest difference between the average scores for the three colleges.13. T - test : for two independent samples and unequal. The researcher used it to find a sign of the moral differences between the first stage and the students of the fourth stage at the Faculty of Fine Arts in the level of self - consistency, as well as the use of the knowledge of the moral significance of the differences in the sex variable in self - consistency among students.Search results : Current search yielded the following results : 1. Having a positive impact for the study of art in diverse branches of self - consistency of the Babylon University students, thus I refused the null hypothesis which says (no effect to the study of art in the self - consistency of the University of Babylon students at the level of significance (0.05).2. The lack of a significant difference between the Faculty of Fine Arts departments in the level of self - consistency, which calls for acceptance of the null hypothesis that refers to : No trace of technical specialization variable in the self - consistency of the University of Babylon students at the level of significance (0.05).3. The absence of a significant difference between (male and female) of the fourth stage at the Faculty of Fine Arts in the level of self - consistency, which calls for acceptance of the null hypothesis that refers to : No trace of the sex variable in the self - consistency of the University of Babylon students at the level (0.05 ).

الطرائق المعاصرة في صيانة الاعمال التشكيلية == Contemporary Methods For Maintenance Of Plastic Art Works

اسم المؤلف: سيف حسام علي الشلاه
اسم المشرف: محمد علي علوان عباس القره غولي
الموضوع العام: الفنون الجميلة
السنة: 2016
الموضوع الدقيق: الفنون التشكيلية
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: تناولت مشكلة البحث الموسوم : (الطرائق المعاصرة في صيانة الاعمال التشكيلية) دراسة في الطرائق المعاصرة المستخدمة في صيانة الاعمال التشكيلية. وقد جاء البحث في اربعة فصول : اهتم الفصل الاول بالاطار المنهجي للبحث متمثلا بمشكلة البحث واهميته والحاجة اليه , وهدف | The research which entitled "contemporary methods in maintenance of plastic art works is divided in to four chapters, where the first chapter concerns the systematical frame work of research, that is by : research problem, research importance, research need, research aim, research limits and research terms. so the research deals with the study of the mentioned contemporary methods. research problem also concerns presenting the scientific and technical turn which leads to the development of maintenance procedures that conducted in treating the damages which affected the artistic works. these procedure are according to a modern scientific visions and methods, which differ in a great extent from the traditional methods that were adopted previously in artistic works maintenance. basing on this, the techniques of artistic work remedy were in a direct properties with great evolutions in the plastic art movement along it's long history. so the testers and those who interested in maintenance affairs have to be aware about the successful and active technique for repairing artistic work damages, by more technical and scientific additions which enhanced the artificial contemporary maintenance methods.by this aspect, the research problem originated through the answers of the following question : • what are the maintenance procedures. that adopted by the contemporary methods in the maintenance of plastic art works?• how can a maintenance worker to achive a sort of coordination between the damages nature and the scientific apparatus used for remedy. research importance and its need are integrated , where research concerns the ability of keeping the aesthetic and artistic heritage of art works through repair in its damages, and to renew its display in a better form as well. also to keep abreast of scientific development in maintenance of plastic art works which subjected to the so phisticated technology and science philosophy as well.the research represents an attempt to open the horizons of practical knowledge for researchers in maintenance of plastic art works, and to encourage them to search the nature of this science and to realize its mechanization. the research provides a scientific effort for our plastic art libraries, in order to make it easy for readers and those who concern this topic to get a knowledge about maintenance science in it's both theoretical and practical sides. advanced studies students, also may make use of this research, through their eruditeness on this research especially, research procedures, research results and conclusions, research aim is to make a knowledge about the contemporary methods in maintenance of plastic art works. research limits was specified by the study of the contemporary methods used in maintenance of plastic arts works which executed by different materials on different surfaces. this study includes the scientific procedures, apparatus, technical means, chemical materials and physical stuffs. for time, a group of plastic art works were chosen within the period (1923 - 2005) for place, they were chosen from Iraqi and Egyptian art. chapter two which entitled "The theoretical from work consists of three brochures, the first entitled maintenance concept between science and art" which includes many topics such as : maintenance and repair in concept and the difference between them, aging concept, damage concept, maintenance kinds, maintenance science and revelation techniques in art works. second brochure deals with traditional means and technical mechanization of plastic art works, in which the art work components were explained. third brochure studies the "contemporary methods in maintenance of plastic art works", in which the methods and its mechanization were explained.chapter three assigned for choosing the research group which consisted of (62) sample with different kinds of damages, (38) of them were from Iraq and (24) from egypt, (5) specimens were choosen with different surfaces, (3) from Iraq and (2) from egypt. research procedures were done by maintaining and repairing (5) specimens according to highly phisticated scientific laboratory methods. each art work subjected to a different repairing plan.chapter four consisted of : research results, conclusions, recommendations and suggestions. the researcher concluded a sum of results in the context of the answer of research aim such as : - the experimental knowledge of contemporary maintenance methods widen the importance and value of the work to be repaired treatments that achieve a functional aspect in reforming the artistic work, then presenting it in anew effective manner.that is clear in the specimens of the research sample. - the scientific knowledge of contemporary maintenance methods which used in specimens of research sample effected by the activity of physical and chemical factors, and by their interaction as well. that was clear through conducting many laboratory tests for materials and item used in repairing and maintenance processes.Research treated the specimen (No.4) according to scientific analysis done by vertical photo microscope (V.P.M), which contributed in repairing treatments of damages through marking the detects, cracks, detachment and revealing the original clours. Researcher applied the process which known "Fourier transform in treated spectroscopy" (FTIR), for repairing the specimen (No.4) through making use of it to find out the work consistent and the way by which the colours were applied.Researcher had concluded the following conclusions : • repairing treatment according to contemporary maintenance methods contributed in displaying a new results, which differ from the results of traditional previous methods. That is because of the use of the new developed techniques of the modern maintenance apparatus, as well as using a specialized new devices which operate quickly and precisely.• The use of contemporary scientific apparatus shows a variety categories of testing and scientific analysis for all detects and damage that infect the painting, beside showing the ability of damage treatment by the adopted maintenance and repairing mechanization. Then it is clear that the joining of analysis process with maintenance treatment emphasizes the necessity of searching of temporary scientific and technical alternatives, coming to enhance the structure of the artistic work and repairing it as well, beside keeping it away from danger and circumstances which may infect it.Researcher submitted a sum of recommendations, suggestions and a list of resources.

بنية الخطاب في الاشكال الواقعية للخزف المعاصر == The Structure Of The Speech In Real Forms Of Contemporary Ceramics

اسم المؤلف: حوراء كاظم عبد الحسين شبر
اسم المشرف: تراث امين عباس
الموضوع العام: الفنون الجميلة
السنة: 2016
الموضوع الدقيق: الفنون التشكيلية
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: انطوى الخطاب الواقعي على معاني دلالية تعد مؤشرات العقل وطبيعة النظر الى العالم والحياة, الامر الذي جعل من الشكل الواقعي خطابا متحركا يتسم بطابع الهيمنة والتعدد والتنوع, تبعا للتحولات الفكرية والتقدم العلمي والتكنولوجي فضلا عن دور الفنان /الخزاف في خلق | This involved the realistic discourse on the tag metals are mind indicators and the nature of looking at the world and life, which made of shape realistic speech moving in character hegemony and pluralism and diversity, according to the transformations of intellectual and scientific and technological progress as well as the role of the artist / potter in creating speech Khozvia reflect the reality of their community and their culture and Aydlewjyatem through an important tool, but a ceramic art form Vakzb realistic structure of knowledge and replace it from rolling to the reality and the reality of a new esthetic and it Address the current research study (the structure of the speech in real forms of contemporary ceramics), which is located in the four chapters devoted the first chapter to a statement of the research problem and identified by answering the question follows : What is the structure of the speech in real forms of contemporary ceramics?And it demonstrated the importance of research to highlight the dominant in the Western world of letters to find out what is happening in the Western world and the culture of their community, as is the art realistic cornerstone in our contemporary life and as an opportunity to recognize the cognitive facts also included the figure unrealistic technical letters with inferences of thought which have an impact Brphi curriculum in cognitive and academic institutes and colleges and the Centre for Fine Arts.While ensuring objective of the study know discourse structure in realistic forms of contemporary ceramics and at the level of the cultural pattern contained therein that form either the limits of the research included the objective limits studying business ceramic realism of the forms and the limits of temporal from the (2000 m - 2015 m) and the limits of spatial in the United States and some European countries They also reviewed the terms are (infrastructure, letter, shape, realism).While the second chapter of the theoretical framework and the most important indicators that resulted, and previous studies, as it included a theoretical framework three sections explain which influenced the speech unrealistic shifts intellectual, mental and the accompanying change of ideological ideas, social conventions taking place in the center of human things that make each style stage a certain amount of rhetoric unrealistic, and therefore have Me first section addressing approaches conceptual discourse the second section was devoted eating discourse realistic across different time period explained through which shifts discourse realistic structure in the ancient art of the Middle Ages and then in the Renaissance and then shift Alazaara discourse realistic in contemporary art while eating the third section speech figure in contemporary ceramics.The third chapter dealt with procedures for search and included the research community and appointed by the research methodology, which the researcher approach adopted Alosfi - method of analysis based on the indicators resulting from the theoretical framework as a tool for the analysis of the sample, (15 guestrooms) in accordance Khozvia from an adult search community number is (159) in accordance with Khozvia.The fourth chapter discusses the results reached at her research, including : 1. The speech took formations cognitive structure in the form of a realistic and contemporary modes of communication in order to make it within the circle of virtual reality, for reality puts an endless production of images.2. cleared discourse structure in Figure realistic ceramic, Kpnip synchronous moving up to read the event through the picture, and create an image of the event, and in both cases is the characterization of the reality of the current era, and this is what made the unrealistic figure holds a narrative structure.3. Generate realistic figure in the contemporary ceramic art a moving speech in the field of sensual pleasure, came realistic figure, such as building a knowledge of the structure of the speech from the visual experience.As well as the conclusions of the research, including : 1. The structure of discourse in contemporary ceramic forms of realism, is the restoration of the Queen of the perception of the taste aesthetic ceramic formations process visually, after the departure of those models Zmcantiha first and functions.2. The structure of the contemporary discourse in the form of a realistic ceramic axes can be included daily events of contemporary life and the requirements of modern man, and the culture of consumption and commodification of social and that social structures and economic structures, political structures, and the culture of technology and electronics.3. The forms constitute a realistic reading and revive the values of margins and documents that make up the culture of the current era, and realistic figure in contemporary ceramics, converts vocabulary borrowed the structure of the group of letters.And continue with the conclusions and recommendations were followed by suggestions The list of sources and references.
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