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تاثير احمرار الدم الثانوي الدم على وظيفة بطانة الاوعية الدموية الجهازية في محافظة بابل == Effect Of Secondary Polycythemia On Systemic Endothelial Function In Babylon Province
Author name:
احمد محي الدين سهراب
Supervisor name:
غافل صيهود حسن الشجيري | عامر صاحب المؤمن
General topic:
Medicine
Specific topic:
Physiology
Degree:
Master
University:
University of Babylon - Faculty Of Medicine - Department Of Physiology And Medical Physics
Language:
English
University location:
Babylon
First pages:
19T1126 - p.pdf
Abstract:
تغير قطر الشريان العضدي كاستجابة الى الاحتقان , يستعمل بصورة واسعة لتقيم وظيفة بطانة الاوعية الدموية الجهازية بواسطة تسجيل التغير كاستجابة للاحتقان. ضعف او قلة التوسع يلاحظ بصورة واضحة لدى المرضى المصابون باحمرار الدم الثانوي.التوسع المحدث بالمد يقاس كن | Brachial artery diameter variations in response to hyperemia were widely used for the assess endothelial function by recording variations in response to hyperemia. Vasodilation was markedly impaired in polycythemic patients.Flow mediated dilatation (FMD) was measured as the percentage increase in brachial artery diameter at diastole after 5 minute of ischemia.Objectives : Material and MethodsThe present study was conducted at Echo - Doppler department in Marjan medical city / Hilla , in cooperation with the department of physiology of College of medicine / University of Babylon, from November 2015 to April 2016. A history, physical examination, blood pressure, and laboratory were performed on all subjects (patients with secondary polycythemia, and control groups). Seventy subjects were included in the present study. Their ages was ranged between 40 - 60 years. They were divided into two groups. Group 1 : Included 30 healthy subjects without polycythemia, all men, their mean age was 47.20 ± 7.3 years and they served as control group.Group 2 : Included 40 patients, all men, with secondary polycythemia, their mean age 46.90 ± 7.3 years.Method : Measurement of flow - mediated and nitroglycerin - induced dilatation of the brachial artery.Measuring blood pressure, auscultatory method.Assessment of BMI.Laboratory analyses : Serum urea test.Serum creatinin test.White blood cells (WBCs) count : Platelets count.Estimation of packed cell volume (PCV %).Red blood cells (RBCs) count. Hb. level test.Cholesterol test.Triglyceride test.Urea test.Creatinine test.Results : The mean flow mediated dilatation (FMD) on two groups was significantly (p value < 0.01) decreased (16%) in patients group (8%) comparison to control group (24%). The mean Hb concentration was significantly (P value < 0.01) increased in patients group compared to control group.The mean packed cell volume (PCV) was significantly (P vale < 0.01) increased in patients group compared to control group.The mean FMD was found to be significantly (16%) decreased in smoker patients group (8%) compared to nonsmoker control group (24 %).The mean red blood cells count was significantly (P value < 0.01) increased in patients group compared to control group.It was found that triglyceride level significantly increased (P value < 0.01) in patients group compared to control group.There was negative correlation between triglyceride and FMD in patients group. Their are No correlation between age and FMD in patients group.The mean serum cholesterol level was not significantly ( p value < 0.07) increased in patients group compared to control group , while serum triglyceride level, serum creatinin, serum urea were significantly ( p value < 0.01) increased respect in patients comparison to control. Mean glucose, Platelets and red blood cells counts were significantly (P value < 0.01) increased in patients group (polycythemic group) respectively compare to control group respectively.Mean body mass index (BMI) and packed cell volume (PCV) were significant (P value < 0.01) increased respectively in patients group compared to control group. Ages of patients group was non - significantly (P value = 0.89) decreased (46.90 ± 7.00 years) in patients group compare to control group.Conclusions : 1 - The mean flow mediated dilatation (FMD) was significantly decreased (16%) in patients group compared to control group. 2 - The mean Hb concentration , mean packed cell volume (PCV) , red blood cells count, platelets , and body mass index count was significantly increased in patients group compared to control group.3 - Polycythemia as with endothelial dysfunctions that may perform in diagnosis of arterial disease. That used to estimate whereas endothelial dysfunctions result from problem in the cardiovascular system with problem in the prothrombin time.4 - Polycythemia can result in raises causes of thrombosis.Through increase platelet dysfunctions, increase ; white blood cell counts, Hb count, homocystein and cholesterol level as with endothelial dysfunctions.
