تقييم المؤشرات السريرية وبعض الدلائل الحيوية في مرض دواعم الاسنان == Evaluation Of Clinical Parameters And Some Biomarkers In Periodontal Disease
Author name:
امل عليوي حسن
Supervisor name:
سعد مرزة حسين الاعرجي | وسام وهاب الحمادي
General topic:
Medicine
Specific topic:
Physiology
Degree:
Master
University:
University of Babylon - Faculty Of Medicine - Department Of Physiology And Medical Physics
Language:
English
University location:
Babylon
First pages:
19T1127 - p.pdf
Abstract:
امراض دواعم الاسنان هي مجموعة من امراض الالتهابات التي تصيب التجويف الفموي وتعرض الهياكل الداعمة للاسنان للخطر. تحدث هذه الامراض بسبب عدم التوازن بين الجراثيم المحيطة بالاسنان واستجابة المضيف. يعتبر مرض التهاب اللثة ومرض النساغ المزمن هي من الاقسام الرئيس | Periodontal diseases are a group of inflammatory diseases that affect the oral cavity and jeopardize the supporting structures of teeth. They are caused by an imbalance between periodontal pathogens and host responses. Gingivitis and chronic periodontitis are the major categories of these diseases. The study sample consisted of 80 individual of both genders, their age ranged from 30 to 50 years, and they are divided into three main groups according to the clinical periodontal parameters (plaque index, gingival index, bleeding on probing index, probing pocket depth index and clinical attachment level index). Group ? comprised from 24 (15 female and 9 male) healthy gingival volunteers as a control, group ?? comprised from of 29 (12 female and 17 male) patients with gingivitis, lastly group ??? comprised from 27 (11 female and 16 male) patients with chronic periodontitis. Unstimulated whole saliva samples are collected to determine the levels of Prostaglandin E2, Matrix Metalloprotinase - 8 and Alkaline Phosphatase. Clinical periodontal parameters are recorded at four sites per tooth. The results of present study revealed a highly significant difference (P - value < 0.01) in the mean ± SD for all of clinical periodontal parameters and for the levels of salivary biomarkers (Prostaglandin E2, Matrix Metalloproteinasee - 8 and Alkaline Phosphatase) among chronic periodontitis, gingivitis and control groups. The chronic periodontitis group revealed the higher mean value followed by the gingivitis group and the control group presented the least value. Regarding the correlation between the salivary biomarkers levels and clinical periodontal parameters, the present study showed a significant positive correlation (P< 0.05) and a highly significant positive correlation (P - value < 0.01) between each of salivary biomarker levels and all of clinical periodontal parameters. In addition, this study showed a highly significant positive correlation (P - value < 0.01) between Prostaglandin E2 and Matrix Metalloproteinasee - 8 and a significant positive correlation (P< 0.05) between Prostaglandin E2 and Alkaline Phosphatase and between Matrix Metalloproteinasee - 8 and Alkaline Phosphatase for gingivitis and chronic periodontitis groups. The present study re - emphasized the importance of whole saliva as sampling method in relations of immunological purposes in gingivitis and chronic periodontitis and proposed that the elevated levels of Prostaglandin E2, Matrix Metalloproteinasee - 8 and Alkaline Phosphatase may be one of the host - response mechanisms connect with the clinical appearances of periodontal diseases. Salivary Prostaglandin E2, Matrix Metalloproteinasee - 8 and Alkaline Phosphatase levels may reflected the severity of disease, thus help in the early detection of the disease.
