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تقييم تاثير التيجان المقاومة للفولاذ (تقنية الهول) على معالجة التسوس للطواحن اللبنية : دراسة رجعية Evaluation of The Influence of Preformed Metal Crown ((Hall Technique)) On The Managing of Carious Primary Molars A Retrospective Study

اسم المؤلف: ورف محسن موسى
اسم المشرف: بان علي صالح
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: طب اسنان الاطفال
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : When prevention of dental caries fails, and a child is exposed to the risk of pain and infection, the disease must be managed to reduce this risk. There is a growing evidence supporting more 'biological approaches' for managing dental cariesin primary teeth. The Hall Technique is one of the biological approaches for managing caries in primary molars which involves sealing caries beneath preformed metal crowns (stainless steel crowns). The crown is cemented over the tooth without theuse of local anesthesia, caries removal, or tooth preparation. The clinical steps for the Hall Technique are straightforward but, as with all dental care provision, appropriate treatment planning for the procedure requires skill. The Hall Technique offers anothermethod of managing early to moderately advanced, active carious lesions in primary molars, with good evidence of effectiveness and acceptability.Aims of the study : This study was conducted to assess the possible local factors that might happen along with using this novel technique regarding the possible adverse effect of the increased occlusal - vertical dimension and the condition of the surrounding tissues.Also to assess the correlation between the rate of the successful outcome with the caries extension towards the pulp.In addition to evaluate the cost - effectiveness of the Hall Technique in comparison with the conventional restorations. Finally to estimate whether this technique can be performed efficiently by both the specialized dentists and general practitioners in terms of putting the appropriate treatment plan based on the radiographic assessment.Material and methods : A retrospective research was conducted, standardized bitewing radiographs of 100 patients between 3 - 9 years old were evaluated for marginal bone changes. The distance between the cemento - enamel junctions and the alveolar bonecrest was measured. The dentine was evaluated as well regarding the existence of clear band of dentine and the extension of the caries towards the pulp of the tooth. - The cost effectiveness was conducted by creating a scenario of the possible outcomes for the treatment decision whether it was Hall preformed metal crown or traditional restoration. Incremental cost - effectiveness ratio was calculated to find the savingamount value. - A panel consisting of five general practitioners and three specialized dentists weas asked to evaluate twelve bitewings radiograph presented to them and give their opinion whether these radiographs are suitable for Hall Technique or not.Results : The result of this presented study showed that there is decreasing in the distance between the cemento - enamel junction and alveolar bone level at the Hall PMCs treatment side between the before and after insertion periods.it also showed thatthere's no different bone level changes between the Hall preformed metal crown treatment side and its contra - lateral side regardless of its condition (Hall preformed metal crowns, no Hall preformed metal crowns). - A high rate of successful treatment is highly associated with observing a clear band of dentine but it is not associated with the carious extinction toward the pulp as long as a clear band of dentine can be seen. - The Hall Technique is more cost - effective by making more cost saving and more gained teeth. The Hall Technique can be performed efficiently by both the general practitioners and the specialized dentist.Conclusion : according on the results of this research it can be settled that there are no adverse effects of using Hall preformed metal crowns regarding the increase of occlusalvertical dimension and the periodontal condition also the Hall Technique is more costeffective and can be performed by specialized dentists as well as the general practitioners.

تقييم تاثير وجود الكحول في الغسولات الفموية على تلاشي قوة السلاسل التقويمية المرنة المختلفة الاشكال : دراسة مختبرية Evaluation of The Effect of Alcohol Presence In Mouth Washes On Force Degradation of Different Configurations of Elastomeric Chains (An In Vitro Study)

اسم المؤلف: نور نوري عباس عبد الله
اسم المشرف: نضال حسين غايب
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: تقويم الاسنان
الدرجة: ماجستير
الجامعة: جامعة بغداد - كلية طب الاسنان - قسم تقويم الاسنان
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Elastomeric chains are one of the most commonly used force delivery systems. They have the ability to exert an interrupted force, convenience of use, compatibility to oral environment and cost effectiveness despite of the inherited disadvantage which is force degradation.This in vitro study was designed to evaluate the effect of alcohol presence in mouthwashes on force degradation of different configurations of clear elastomeric chains from Ortho Technology company which are : closed, short and long under the effect of time at different intervals (Initial, 1day, 1, 2, 3 and 4 weeks) with exposure to different chemical solutions.A total of (540) elastomeric chains of three different types (long, short and closed) transparent in color, with an initial length (19mm) and about 50% extension (29mm) were used for the study. These elastomeric chains was divided into four groups and exposed to different chemical solutions (Distilled water, Listerine Original alcoholic mouthwash, Listerine Zero alcohol mouth wash, Ethanol 26.9%) twice daily for 60 seconds each according to manufacturer's instructions to measure the amount of force degradation in different time intervals. These elastomeric chains were incubated in covered glass containers at 37C? for the entire testing period.The results of the present study showed that the elastomeric chains were greatly affected by time, the majority of force loss occurred after the first 24hr. then followed by a less steep gradient for the rest of the working period.We can conclude that alcoholic mouth wash (Listerine Original) causes an increase in force degradation of all types of elastomeric chains while alcohol free mouth wash (Listerine Zero) causes less force degradation of all types of elastomeric chains, additionally closed configuration elastomeric chains has the least percentage of force degradation than other configurations of elastomeric chains.

الحركة الوحشية للطاحن العلوي الاول باستخدام انواع مختلفة من الاجهزة مسبقة الصنع : دراسة مختبرية مقارنة Distal Movement of Maxillary First Molar Using Different Types of Ready Made Appliances : An In Vitro Comparative Study

اسم المؤلف: ليث عمر المولى
اسم المشرف: هند طاهر جرجيس
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: تقويم الاسنان
الدرجة: ماجستير
الجامعة: جامعة بغداد - كلية طب الاسنان - قسم تقويم الاسنان
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Maxillary molar distalization is an important method for correcting class II molar relationship.The important thing in the use the distalizing appliances is to reduce the patient cooperation with minimizing the effects of distalizing appliances on the anchoring teeth.Aims : The aim of this study is to compare three different intra - maxillary molar distalization devices with different designs , force direction. Other aims are to compare the effect of these devices on first permanent molars in mesiodistal , buccopalatal, rotational aspects. It aims also to compare the effect of these devices on the first premolar ( which is a part of anchoring system ).Materials and Methods : The samples consisted of three groups; Frog appliance, K - Loop spring and Multidistalizing arch on typodont simulation system (Ormaco). Upper typodont arch of class II division I was used.Pre and postoperative digital images were taken and analysed using AutoCAD software for each group, Six parameters was measured and compared ; first molar ( vertical change ,tipping change ,rotation, distalization rate) and first premolar (vertical change ,tipping change).A significant value of 0.05 was determined.Results : The results of present study showed that the multidistalizing arch gave rise a significant distal tipping, extrusion, distopalatal rotation of first molar and gave rise the highest mean value of first molar distalization rate. Also, gave rise a significant distal tipping and extrusion of first premolar.Frog appliance showed the lowest mean value of molar distalization rate ,distal tipping and rotation , in comparison with Multidistalizing arch (MDA) and K - Loop spring. Also, these parameters ranged between the highest and lowest mean value in extrusion of first molar , first premolar vertical change , Also showed lowest mean of distal tipping of first premolar than Multidistalizing arch (MDA).K - Loop spring ranged between the highest and lowest mean value distalization rate , distal tipping of first molar. Also, showed the lowest mean value in extrusion of first molar and extrusion of first premolar and rotation of first molar.However, The K - Loop spring show mesial tipping of first premolar in comparisom with (MDA) and Frog appliance that show distal tipping of first premolar.Conclusions : It is concluded that the three methods are effective in molar distalization. The best method of first molar distalization ranged between the K - Loop spring and Frog appliance. Consequently the two methods showed good amount of molar distalization with minimal effects on first molar and first premolar.

تاثير التدخين الخفيف على المستويات اللعابية لانزيم الفوسفاتيز القلوي والاوستيوكالسين لدى مرضى التهاب اللثة المزمن Effects of Light Smoking On Salivary Levels of Alkaline Phosphatase And Osteocalcin In Chronic Periodontitis Patients

اسم المؤلف: لبابة عبد الصمد عبد الامير
اسم المشرف: باسمة غفوري علي
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: امراض ما حول الاسنان
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background Chronic periodontitis is an inflammatory disease that affects the supporting tissues of the teeth and it is common among adults. Smoking is an important risk factor for periodontitis that induces alveolar bone loss. Alkaline phosphatase enzyme is involved in the destruction of the human periodontium. It is produced by many cells such as polymorphonuclear leukocytes, osteoblasts, macrophages and fibroblasts within the area of the periodontium and gingival crevice. Osteocalcin is one of the most abundant matrix proteins found in bones and the only matrix protein synthesized exclusively there. Small osteocalcin fragments are found in areas of bone remodeling and are actually degradation products of the bone matrix.Aims of the study 1. Investigate whether light smoker chronic periodontitis patients exhibit different salivary concentrations of Alkaline Phosphatase and Osteocalcin compared to the non - smoker counterpart and compare to light smoker and nonsmoker control groups and 2.Correlate the clinical periodontal parameters (plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment level) to the biochemical findings in light smokers and non - smokers chronic periodontitis and control groups. 3. Estimation of the salivary PH and flow rate and correlate them with clinical periodontal and biochemical parameters. Materials and Methods Five ml of unstimulated whole saliva samples and fullmouth clinical periodontal recordings (plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment level) were obtained from study groups (25 light smokers and 33 non - smokers subjects, both with chronic periodontitis) and control groups (8 light smokers and 13 non - smokers subjects, both with healthy periodontium). All subjects were systemically healthy males, with age range (30 - 50) years. Salivary Alkaline phosphatase and Osteocalcin levels were determined by Colorimetric and Enzyme - linked Immunosorbent Assay, respectively. Salivary PH and flow rate were also measured.Results Smoker chronic periodontitis patients revealed non - significant differences in clinical periodontal parameters with non - smoker counterparts (P > 0.05) in terms of plaque index, probing pocket depth, clinical attachment loss, salivary PH and flow rate, with slight increase in plaque index value in smoker chronic periodontitis group(1.42±0.46) than non - smoker chronic periodontitis group (1.38±0.50), while there was slight decrease in mean value of probing pocket depth (3.90±1.78), clinical attachment level (3.22±0.93) and PH (7.58±0.50) in smoker chronic periodontitis group than non - smoker chronic periodontitis group (4.27±1.98), (3.74±0.85), (7.73±0.33) respectively. Flow rate value was higher in smoker chronic periodontitis (4.80±2.69) than non - smoker chronic periodontitis group (4.67±2.09). While there were highly significant differences in terms of gingival index and bleeding on probing (P ? 0.01). Osteocalcin levels were lower in smoker chronic periodontitis group (0.13±0.20) than non - smoker chronic periodontitis group (1.09±2.26) with significant difference (0.05 ? P > 0.01). Highly significant, strong, positive correlations were found between Osteocalcin concentration with plaque index and PH in non - smoker control group. Correlation analysis between Osteocalcin concentration and flow rate in smoker chronic periodontitis group revealed a significant, moderate, positive correlation.Mean of Alkaline phosphatase level was lower in smoker chronic periodontitis (11.14±4.53) than non - smoker chronic periodontitis (11.45±4.17) with a nonsignificant difference, while there was a significant difference in Alkaline phosphatase concentrations between smoker and non - smoker control subgroups.Correlation analysis between ALP concentration and clinical periodontal parameters (plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment level) in chronic periodontitis smoker group appear non - significant, weak,negative and related non - significantly, weakly, positively with PH and flow rate. Clinical attachment level and PH correlated non - significantly, weakly, negatively with Alkaline phosphatase concentration, while plaque index, gingival index, bleeding on probing, probing pocket depth and flow rate related non - significantly, weakly, positively with Alkaline phosphatase concentration in chronic periodontitis non - smoker group. There was a significant, moderate, negative correlation between salivary PH and bleeding on probing and significant, weak, negative correlation regarding probing pocket depth in smoker chronic periodontitis group.A significant, weak, positive correlation between salivary flow rate and clinical attachment level was found in non - smoker chronic periodontitis group.There were non - significant differences between smoker chronic periodontitis and smoker control groups in terms of salivary PH, flow rate, Osteocalcin and Alkaline phosphatase concentrations. There were non - significant differences between non - smoker chronic periodontitis and non - smoker control groups in terms of PH, flow rate, Osteocalcin and Alkaline phosphatase concentrations. There were non - significant, weak increase in Alkaline phosphatase concentration compared to the increase in Osteocalcin concentration in smoker and non - smoker chronic periodontitis and smoker control groups, while there was a nonsignificant, weak decrease in Alkaline phosphatase concentration with increase in Osteocalcin concentration in non - smoker control group. Conclusion Within the limits of this study, it may be suggested that suppression of salivary Osteocalcin levels by smoking and weak increase in Alkaline phosphatase in smokers groups, may explain the deleterious effects of smoking on periodontal healthstatus.

تاثير انابيب الكاربون النانوية متعددة الجدران على الصلادة والتوصيلية الحرارية لمينا الاسنان Effect of Multi - Wall Carbon Nano Tubes On The Microhardness And Thermal Conductivity of Dental Namel

اسم المؤلف: محمد كاظم جواد
اسم المشرف: عباس فاضل علي
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: الانسجة الفموية
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The objectives of this study was to evaluate the effect of addition of Multi - Wall Carbon Nano ubes(MWCNTs) of different concentration (0.05 mg/mL - 1, 0.25 mg/mL - 1, 0.5 mg/mL - 1and 1 mg/mL - 1) with on either (dimethyl sulphoxide DMSO and distilled water DW) on tooth enamel. It is intended to evaluate enamel microhardness in (Kg.m - 2) and enamel thermal conductivity before and after the application of (MWCNTs).Ninety mandubular first premolar were prepared for this study. They were divided into two groups. The first group contains 54 sample to measure the microhardness of the enamel. To overcome the teeth curvature in microhardness measurement, the position of indenter were optimized to coincide linear buccal surface. The second group contains 36 sample to measure the thermal conductivity of the enamel were prepared by cutting enamel part in triangle form with a base of 7. 5 mm , height of 9. 5 mm and thickness of 2 mm according to the requirements of the Fourier’s law by abrasive disk.The results enamel microhardness showed that a significant increase in the enamel microhardness and enamel thermal conductivity for groups 0.05 mg/mL (group B) , 0.25 mg/mL (group C ) , 0.5 mg/mL (group D ) and 1 mg/mL (group E ) compared with control group (group A ) in DW media and DMSO media. The results showed a significant increase in the enamel microhardness and enamel thermal conductivity for polished samples compared with unpolished samples in DW media and DMSO media. DMSO media increases the enamel microhardness and enamel thermal conductivity more effectively than DW media. Scanning electron microscope showed a significant deposition of MWCNTs in the depth of the enamel exceeding the surface layer. The polished specimens had more deposited MWCNTs compared with non - polished specimens. However, the nano dimensions with conjunction with pre - chemical treatment enabled the MWCNTs to penetrate and settle down inside the enamel.The final conclusion highest mean value obtained was 1 mg/mL (group E ) in the enamel microhardness and enamel thermal conductivity suspension in DW media and DMSO media.

دراسة لتحويرات نانوية مختلفة لسطح زرعة الاسنان من معدن التيتانيوم النقي تجاريا باستعمال الطريقة الكيميائية وطريقة التبخير الحراري : تقييم ميكانيكي ونسيجي Study Different Nano Surface Modifications On CPTi Dental Implant Using Chemical And Thermal Evaporation Methods : Mechanical And Histological Evaluation

اسم المؤلف: بان ناهل شكر
اسم المشرف: رغداء كريم جاسم
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: صناعة الاسنان
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Dental implants provide a unique treatment modality for the replacement of lost dentition. The clinical success of implants has been achieved not only because of the mechanical strength or cellent biocompatibility of the implant material but also owing to other characteristics such as surface properties.Aims of the study : The goal of this study was to consider the role of nanoscale topographic modification of commercial pure titanium dental implant using a thermal deposition and chemical etching methods for the purpose of improving osseointegration.Materials and methods : Commercial pure titanium rod was machined into 40 dental implants. Each implant was machined in diameter about 3mm, length of 8mm (5mm was threaded part and 3mm was flat part). Implants were prepared and divided into 4 groups according to the types of surface modification method used : 1st group (10 implant) machined surface i.e remained without nano surface modification (control),2nd group include (10 implant)etched with 15N H2SO4 and 30% H2O2,3rd group include (10 implant)were coated with nano CPTi powder by thermal evaporation deposition technique,4th group (10 implant)were chemically etched with H2SO4 and H2O2 method to obtain a nano feature then coated with nano powder of CPTi by thermal evaporation deposition technique.Nano surfaces were characterized by scanning electron microscope (SEM), Xray diffraction (XRD), atomic force microscope (AFM), thickness measurement and microscopical examination for the invitro experiments. For the invivo part of study, the tibia of 10 white New Zealand rabbits were chosen as implantation sites. The tibia of each rabbit received two screws. Biomechanical test was performed after two weeks healing periods. Implants from eight animals were tested for the torque required to remove the implantfrom the bone and the other two animals were prepared for histological examination.Results : For invitro results, scanning electron microscope showed that chemical etching of Ti substrate becomes highly porous and has surface consisting of nano_sized pits and the combination of chemical etching and thermal evaporation of nano Ti showed nano rod like structure. The results of removal torque means value after 2 weeks of implantation showed that, there was a gradual increase in the removal torque mean values in the studied groups as a follow (M±SD) : 12.625 N.cm ± 0.517 machined surface, 30.500 N.cm ± 4.071 chemically etched, 46.875 N.cm ± 5.938 nano CPTi coating by thermal evaporation method, 51.250 N.cm ± 5.175 combination method of chemical etching and nano CP Ti coating. In addition, the histological analysis showed improved quality of bone in response to the nano surface modified screws, especially the combination treated implants show a well developed mature bone characterized by a well developed bony threads and haversian canal. Conclusion : The biomechanical and biological properties of the bone - implant interface associated with the nano modified implants were improved comparing to the unmodified implants. All nano modified CP Ti seems to be well tolerated by the bone since no adverse tissue reaction was evident and they have better mechanical properties and excellent biocompatibility through the improved performance regarding the bone implant contact area than the untreated implants.

نقييم الالفا اميليز والكورتيزول في اللعاب كمؤشرين جيويين للتوتر النفسي وعلاقتها بامراض المفصل الصدغي بين عينة من طلاب كلية طب الاسنان Assessment of Alpha - Amylase And Cortisol As Salivary Psychological Stress Markers In Relation To Temporomandibular Disorders Among A Sample of Dental Students

اسم المؤلف: سرمد قيس علي
اسم المشرف: رجاء هادي الجبوري
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: طب الاسنان
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : University dental students perceived a higher level of stress prior to each examation especially the final. Therefore, there is a need for a useful noninvasive biomarker for measuring acute stress in those students. Many studies considered salivary alpha - amylase as a stress biomarker that is most often used in conjunction with cortisol. Understanding of the exact association between these two salivary stress markers are poorly established. Using a Helkimo anamnestic and clinical dysfunction scoring index for temporomandibular disorders can give a better insight about the association between these markers and temporomandibular joint disorders.The aims of study : was to evaluate the levels of salivary alpha - amylase and salivary cortisol in stressed students with temporomandibular joint disorders and the differences between these markers in relation to temporomandibular joint disorders students. This might give a better understanding to the role of psychological stress as an etiological factors for developing temporomandibular joint problems.Subjects, materials and methods : A total eighty (60 study and 20 control) participants aged between 20 and 24 years, were recruited for this study. The participants were final year undergraduate Baghdad university dental students who were examined and gave saliva samples before their final academic examination. Those with temporomandibular joint disorders problems were exposed to psychological stress and included on the study. While, those who were taking corticosteroids or hormone supplementation including oral contraceptives, or having history of head injury, orthodontic treatment, occlusal disharmonies and muscle tenderness due to systemic diseases as fibromyalgia, or having more than 2 missing posterior teeth were excluded. Salivary assay kits (alpha - amylase and cortisol) were used to measure those variables and a Helkimo anamnestic and clinical dysfunction scoring for temporomandibular joint disorders were utilized in this study.Results : There is statistically a highly significant difference of the salivary cortisol and salivary alpha - amylase in the patient group( stress with temporomandibular joint disorders) and control group. The absence of correlation between these salivary markers was founded. Correlation analysis of salivary cortisol with Helkimo anamnestic and clinical dysfunction score shows positive association expressed by significant probability of error (p) value while for salivary alpha - amylase there is no association.Conclusion : This study demonstrates that salivary alpha amylase can be used as a stress biomarker in conjunction with cortisol to assess temporomandibular joint problems due to psychological stress in university students.

الظواهر الوجهية والفموية، عوامل الاكسدة ومضادات الاكسدة في مصل ولعاب مرضى فقر الدم البحر الابيض المتوسط نوع بيتا في مدينة كربلاء Oro - Facial Manifestations, Oxidative Stress And Antioxidants Markers In Serum And Saliva of Patients With Beta Thalassemia Major In Karbala City

اسم المؤلف: مؤيد صاحب عباس شمسه
اسم المشرف: تغريد فاضل زيدان
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: طب الاسنان
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Thalassemia is a hereditary anemia resulting from defects in hemoglobin production. Beta Thalassemia, which is caused by a decrease in the production of beta globin chains, affects multiple organs and is ssociated with considerable morbidity and mortality. Aims of the study : The aims of this study were to study the oro - facial manifestations in beta thalassemia major patients and evaluation of the oxidative stress status in serum and saliva represented by malondialdehyde as xidative stress indicator and also assessment of serum and saliva antioxidants which are ceruloplasmin and uric acid in beta thalassemic patients with and without periodontitis and compared that with the healthy individuals in addition to investigate the relation between the clinical findings and laboratory investigations.Methods : Eighty seven (87) subjects were consented and contributed in this study, twenty eight (28) thalassemic patients with periodontitis, thirty (30) thalassemic patients without periodontitis and twenty nine (29) healthy subjects that were age matched with the patients. Oral examination has been done for each subject. Serum and saliva sample have been taken from each subject for analysis, to study malondialdehyde as oxidative stress and antioxidants ceruloplasmin and uric acid.Results : Malocclusion was the most common prevalent oro - facial manifestations (60%), followed by rodent face (35%), brown pigmentation of oral mucosa (23%) and incompetent lip (8%). The mean serum and saliva malondialdehyde were significantly higher in thalassemic patients with periodontitis than that in thalassemic patients without periodontitis and healthy subjects (p<0.001), while the mean serum and saliva ceruloplasmin were significantly higher in control group than that in other study groups (p<0.001). The mean serum uric acid was significantly higher in thalassemic patients without periodontitis than that in thalassemic patients with periodontitis and healthy subjects (p<0.001) and the mean saliva uric acid was significantly higher in thalassemic patients without periodontitis (p<0.05) compaired with thalassemic patients with periodontitis and healthy subjects. The results of this study showed that there were no significant correlation between serum and saliva malondialdehyde in any of study groups, while there was a positive significant linear correlation between serum and saliva ceruloplasmin in thalassemic patients with periodontitis (p<0.05), a negative significant linear correlation in healthy subjects (p<0.05) , a positive significant linear correlation in thalassemic patients without periodontitis (p<0.001). The results showed that there was a positive significant linear correlation between serum and saliva uric acid in thalassemic patients with periodontitis (p<0.05), a positive significant correlation in thalassemic patients without periodontitis (p<0.001) and no significant correlation between serum and saliva in healthy subjects. On the other hand there were no significant correlation between serum and saliva (malondialdehyde, ceruloplasmin and uric acid) and clinical attachment loss (p>0.05), except a positive significant linear correlation between clinical attachment loss and salivamalondialdehyde (p<0.05) was found. Conclusions : Malocclusion was the most prevalent oro - facial manifestations of beta thalassemia major patients. Oxidative stress play a significant role in the pathogenesis of beta thalassemia ,which was the main cause of red blood cells destruction represented by significant elevation of serum and saliva malondialdehyde and significant reduction of ceruloplasmin. Also oxidative stress remain contributing factor in periodontal tissue destruction, which was appeared as a significant increased level of saliva malondialdehyde and decreased saliva ceruloplasmin in patients with periodontitis and there was a significant correlation between saliva malondialdehyde and clinical attachment loss

التقييم النسيجي والكيمائي النسيجي المناعي لتاثير الاستخدام على VEGF/ N - acetyl D - glucosamine الموضعي ل شفاء العظم : دراسة تجريبية على الجرذان Histological And Immunohistochemical Evaluation of The Effect of Local Exogenous Application of VEGF /N - Acetyl D - Glucosamine On Bone Healing : (Experimental Study In Rats)

اسم المؤلف: ایناس فاضل كاظم
اسم المشرف: عذراء يحيى الحجازي
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: الانسجة الفموية
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Bones are rigid organs that constitute part of the endoskeleton of vertebrates. They support and protect the various organs of the body, produce red and white blood cells and store minerals. Bone tissue has been shown to contain numerous cell - to - cell signaling peptides called growth factors. These growth factors are thought to have important regulating effects for bone remodeling and bone healing. Several growth factors are expressed during fracture repair. of these, vascular endothelial growth factor (VEGF), is of particular interest because of its ability to induce neovascularization (angiogenesis). The responses to exogenous VEGF observed that a slow - release formulation of VEGF, applied locally at the site of bone damage, may prove to be an effective therapy to promote human bone repair. N - acetyl glucosamine is a monosaccharide, which are the derivatives of carbohydrates, it helps the body in making several other chemical agents which are used in the formation of bones, muscles and cartilages.N - acetylglucosamine is very effective in providing support for the skeletal system of the humans, and may provide strength to the ligaments and joints, and the skin remains fresh and glowing. Aims of study1. To identify role of local exogenous application of vascular endothelial growth factor and application of N - acetyl - D glucose amine as a biomaterial in bone healing.2. To analyze the expression of Vascular endothelial growth factor, tissue non specific ALP and bone matrix protein (collagen - 1) by immunohistochemistry in created bone defect after application with different biomaterials in a rat model. Materials and MethodsIn this experimental study fifty four male Albino rats, weighting (300 - 400) gram, aged (6 - 8) months were used and maintained under control conditions of temperature, drinking and food consumption. The animals were subjected for a surgical operation of medial sides of both tibial bone ( right side was considered as experimental site ,while left be the control one). The animals were divided into following groups according to the applicable growth factors.A. Contol group the bone defect treated with 1?m of normal saline and its number represented the all number of the following experimental groups as the left side of each animal considered to be the control.B. Experimental group includes ? Group I contains (18) rats, the bone defect treated with 1?ml of Vascular endothelial growth factor. ? Group II contains (18) rats the bone defect treated with 1?ml of Nacetyl D - glucosamine.? Group III contains (18) rats, the bone defect treated with 1?m combination of (VEGF& N - acetyl D - glucosamine).Every single group composed of 18 rats that studied in three periods 3,7,10 days (6 rats for each period). Histologic and immunohistochemical evaluation for VEGF, alkaline phosphatase and collagen type 1 were carried for all animals.Results : A. For Histological findings An early apposition of osteoid tissue was detected in VEGF group. Osteoblast, osteocyte and osteoclast cells count were demonstrated to be with high mean value in VEGF group followed by N - acetyl Dglucosamine group in periods 3,7,10 days post operative of bone defect.Inflammatory phase as first step in bone healing was detected in all study groups at 3 day, and combination group records highest value in the mean of inflammatory cell count in comparisum to others. Finally thestudy demonstrated that exogenous VEGF/ N - acetyl D - glucosamine has a direct effect on osteoblastic activity.B. For Immunohistochemical findings The present result showed positive expression of VEGF by bone marrow stromal cells, adipocytes, mesenchymal stem cells, precursor endothelial cells, and bone cells include osteoblasts and active osteocytes in different periods in all groups but in different score. Therefore, our primarily data provide evidence that VEGF activity is essential for appropriate bone formation and mineralization in response to injury. At day 3, bone marrow stromal cells in combination group records highVEGF expression, VEGF group is the second. At 7 and 10 day VEGF group records a highest VEGF expression in comparisum to other groups. The data showed a high expression for ALP during the formative stages of bone in all groups except combination group shows the lowest count for positive cells that expressed ALP.the present results showed that at day 3, bone marrow stromal cells in VEGF and N - acetyl D - glucosamine group records high collagen type I expression. Conclusion : the study demonstrated that low application of VEGF / Nacetyl D - glucosamine could be an effective therapeutic for bone injuries, these data are promising for a possible future clinical usage.

Assessment of The Oral Findings, Salivary Oxidative Status And Iga Level Among Group of Workers Exposed To Petroleum Pollutants In Al - Daura Oil Refinery

اسم المؤلف: امير سعد حمزة
اسم المشرف: Jamal Noori Ahmed
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: طب الاسنان
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Petroleum is perhaps the most important substance consumed in modern society. Petroleum is unique and s a complex mixture of thousands of compounds. Oil refinery workers are continuously exposed to numerous hazardous materials and working conditions that place them at continuous risk of injury and death.Petroleum contains the heavy metals as a natural constituent or as additives. The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. Several carcinogenic metals such as arsenic, cobalt, chromium, lead, mercury, and nickel induce redox reactions in living systems. These metals induce the production of reactive oxygen species in both in vivo and in vitro systems. These radicals have rendered oxidative damage to deoxyribonucleic acid, proteins, and lipids. Secretory immunoglobulin A is the main immunoglobulin found in mucous secretions from the tear glands, salivary glands, mammary glands, the respiratory system, the genito - urinary tract, and the gastrointestinal tract.Aims of the study Assessment of the salivary levels of heavy metals among the workers of Al - Daura oil refinery, assessment of the oxidative status in the oral cavity of the workers by measurement of Malondialdehyde and Superoxide dismutase markers,assessment of the oral immunological activity by measurement of secretory immunoglobulin A level in saliva and Assessment of the oral findings among the workers.Subjects, Materials and Methods This study was done in Al - Daura oil refinery, samples consist of 60 workers involved in refining processes as study group subdivided into three subgroups which represent the different sections in the refinery and 20 subjects not involved in refining processes as control group. Oral examination and saliva collection was done to assess the oral findings and measure the level of heavy metals (lead and cadmium), oxidative status (Malondialdehyde and Superoxide dismutase) and secretory IgA.Results The mean of salivary lead and cadmium was higher in study group (6.34 ?g/dl and 0.56 ?g/l respectively) than that of control group (3.3?g/dl and 0.34 ?g/l respectively) with highly significant difference (p

تقيم معارف العناية الذاتية للمرضى المصابين بداء السكري النوع الثاني في مركز السكري في محافظة بابل Assessment Of Self - Care Knowledge Among Type II Diabetes Mellitus Patients At Diabetic Center In Babylon Governorate

اسم المؤلف: سالم كريم هجول الجبوري
اسم المشرف: سلمى كاظم جهاد
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: التمريض
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: اجريت دراسة وصفية (عرضيه مقطعيه) للفترة من 20/10/2015 ولغاية 25/6/2016 من اجل تقييم معارف الرعاية الذاتية لمرضى السكري النوع الثاني في مركز السكري في محافظة بابل. وقد اختيرت عينة هادفة من (120) مريضا باستخدام تقنية اخذ العينات غير الاحتمالية، التي تشمل ا | A descriptive design cross - sectional study has conducted throughout the period of October 20th 2015 to June 25th 2016 in order to assess the self - care knowledge of patients with type II diabetics mellitus at diabetic center in Babylon Governorate. A Purposive sample of (120) subjects were selected throughout the use of non - probability sampling approach, that include patients who were diagnosed with type II diabetes mellitus visiting diabetic center in Merjan medical city/ Babylon Governorate. A questionnaire was constructed to achieve the objectives of the present study, comprised of four domains including (50) items. Data was collected from patients attending for or treatment diabetic center in Hilla city through the use of interview technique, during the duty shift for the purpose of receiving health care, each patients' individually interviewed, helped by the researcher and taking a corresponded period of between ( 20 - 25) minutes. The questionnaire was clear and adequate for the measurement of the phenomenon except some adjustments are made on few items according to the experts' suggestions.Reliability of the questionnaire was determined through a pilot study and the validity was achieved through a panel of (16) experts. Data were analyzed through use of the Statistical Package of Social Sciences (SPSS, Version 20). Reliability was concerned with the consistency and dependability of the research instrument. Determination of internal consistency, reliability of the questionnaire is based on computation of Alpha Cronbach's Correlation Coefficient.The findings of the study indicated that Type II diabetes mellitus age group have old age. Sample less opportunity to read and write.Results of the diabetes mellitus patients demonstrated that sample acceptable level of socio - economic status. Regarding residency it was shown that most Diabetes mellitus type II patients existed in urban areas. study sample was found to score body mass index of overweight feature. Fortunately participants showed a good knowledge about the diabetes mellitus and its complications. In regard to knowledge of sample about self - care it was demonstrated that their achievements were fine. Self - care in diabetes has been defined as an evolutionary process of development of knowledge or awareness by learning to survive with the complex nature of the diabetes in a social context. The recent study summarized that some dietary behaviors need more attention from the patient to regulate and balance the condition, It is interesting to find out that sample study had reached good scores in regard to different issues of self - care except with some exercises and activities related to foot care. As well as current study concluded that Patients' age, levels of education, family history of diabetes and marital status affect their knowledge level as overall. The study recommended that. Patients with chronic diseases like the current one need to be educated in regard to some misconceptions such as treatment of the illness, Although majority of patients know the signs and symptoms of disease, health care facility can help in emphasizing the lack of information in some areas of the subject, Some self - care results show deficits concerning the diet, appropriate strategies such as give priorities to those very vital factors in controlling blood sugar when teaching patients can be used to correct the patients dietary habits. Educational materials or programs designed to assist Patients in practicing some activities to reduce burden of the condition.

العوامل المؤثرة على نوعية حياة المرضى المصابين بالجلطة الدماغية في مركز الفرات الاوسط للعلوم العصبية في مدينة النجف الاشرف Factors Affecting Quality Of Life For Patients With Cerebrovascular Accident In Middle Euphrates Neuroscience Center In Al - Najaf Al - Ashraf City

اسم المؤلف: احمد صالح رضا القاضي
اسم المشرف: سحر ادهم علي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: التمريض
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: خلفية الدراسة : تعتبر الجلطة الدماغية سبب رئيسي مؤثر يقلل مستوى نوعية حياة المرضى. قياس نوعية الحياة للاشخاص الذين يعانون من امراض مزمنة يعطي رؤية واضحة لتحديد اثره على مقدمي الرعاية الصحية عندما تكون النتيجة غير ممكنه. العوامل المؤثرة على نوعية الحياة لم | Background : Cerebrovascular accident is a main leading cause affectedly decrease the level of quality of life of the patients. The measurement of quality of life for population with chronic diseases gives a clear view to determine the impact on health care providers when prognosis is not possible. Factors affecting the quality of life may be vary between different age categorize such as CVA young and old CVA patients, different factors have affected the quality of life, related to the following aspects : motor impairment, physical dysfunction or dependency in activity of daily living, the presence of depression ,cognitive impairment, and speech disturbances.The main aim of the study : To identify the factors affecting the quality of life for patients suffering from cerebrovascular accident.Design of the study : Descriptive cross - sectional study design was selected to achieve the objectives of this study the factors affecting quality of life for patients diagnosed with cerebrovascular accident in Middle Euphrates Neuroscience center in Al - Najaf Al - Ashraf City, for the period between 27 October 2015 and 30 August 2016.Setting : A unique center was selected to conduct the study, the outpatient department in Middle Euphrates Neuroscience center in Al Najaf Al Ashraf City are used to collect the data.Sample of the study : Non probability ( purposive sample ) from patients with CVA (N=80) were selected to find out the factors affecting quality of life for patients with cerebral vascular accident. Data was collected by using an assessment questionnaire which was adopted and developed by the researcher to assess the factors affecting the quality of life for patients with cerebrovascular accident. It is divided of three parts : demographical data as the first part, clinical information is the second part, while the specific CVA quality of life questionnaire which extended to 48 items distributed upon 12 main domains as (energy and activity, family relationship, speaking, movement, mood, personality, self - care, social role, thinking, in addition upper extremities functions, vision, and work / productive ) is the third part. Validity of the questionnaire obtain by (19) experts, who work in different fields to obtain the reability of the questionnaire alpha cronbach was used as a statistical method.The majority of the study sample were between (59 - 69) of age. The highest percentage of the study sample were males and were married. On the other hand the highest percentage of the sample were illiterate , housewives and urban area residents. The scores of the quality of life of the majority of the study sample were high effected regarding the following domains : (energy and activity), plus movement, moderate effect presented related to the family relationship, speaking, mood, self - management, social role, thinking, function of the upper extremities, vision, and job / productive, while low effect score recorded for personality.Conclusion : The overall quality of life level of the CVA patient who participate in the study was moderate. The QOL for patient with CVA were significantly effected related to their age, occupation, and educational level. Chronic diseases, type of CVA and it's duration play as highly effecting factors related to the patient's quality of life.Recommendation : Establishing structured program realizing the challenges that might face the post CVA patients because this long journey need special planned care to improve patient's quality of life by special rehabilitation unit, the unit services may be extended for the patient's family.

الانماط الجينية والبروتين الرابط للرتينول 4 في مرضى الاعتلال الكلوي السكري النوع الثاني Gene Polymorphism And Retinol Binding Protein 4 In Type 2 Diabetic Nephropathy Patients

اسم المؤلف: احمد جبار عباس
اسم المشرف: مها فاضل سميسم علاء حسين ال حيدر
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: داء السكري هو مرض ايضي له تاثير على ايض الكاربوهيدرات والدهون والبروتينات. ومن مضاعفات السكري اعتلال الكلية السكري، الذي يعد السبب الرئيسي للفشل الكلوي المزمن. الليبوكالينات هي عائلة من البروتينات التي تنقل الجزيئات الكارهة للماء صغيرة مثل السروئيدات | Diabetes mellitus (DM) is a metabolic disease involving carbohydrate, lipid, and protein metabolism. Diabetic nephropathy (DN) is the significant complication of diabetes, which is at the present time the major cause of chronic renal failure. The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, retinoids, and lipids. Retinol binding protein 4 (RBP 4) is a member of the lipocalin family of proteins and it has a role in insulin resistance. A meta - analysis demonstrated a significant association between the polymorphism of glucose transporter1 gene with DN. The presence of endothelial nitric oxide synthase (eNOS) polymorphisms may contribute to a decreased eNOS activity and a lowered nitric oxide level, and has been reported to be a potential factor in the development and pathogenesis of DN. The study aimed the evaluation of lipid profiles and determination of their association with retinol binding protein 4 expression in diabetic patients, evaluation of gene expression of eNOS G894T polymorphism in diabetic patients to predict its relationship with nephropathy in future, and evaluation of gene level of GluT1 polymorphism in diabetic patients to predict its relationship with nephropathy in future. This study was conducted in Hilla city, from December 2015 to April 2016. The samples were collected from Babylon Center for Diabetes and Endocrinology in Marjan Teaching Hospital in Babylon / Hilla city.This study was included 160 subjects, who were (35 - 58) years old and BMI between (25 - 29.9) which were divided into groups : Control group 80 apparently healthy persons included 40 male control group (MC) and 40 females control group (FC). Eighty patients with diabetes mellitus type 2 include (40 males group (M)) and (40 females group (F)). Blood samples (10 ml) were taken from fasting subjects. Two milliliters of blood were put in EDTA tube used for the determination of HbA1c and genetic study and 8 milliliters of blood were put in plane tube and centrifuged to separated serum to measure (glucose, insulin, retinol binding protein 4 and lipid profile ( and insulin resistance was measured by equations. The results show : 1. There is a significant increase in the mean of fasting glucose, HbA1c, fasting insulin level, insulin resistance in groups M and F as compared to the control groups, (p<0.01), but there was no significant increase between two patient groups (p ? 0.05)2. The significant increase (P <0.01) in total cholesterol (TC), TG, LDL - C and VLDL - C, while serum HDL - C concentration was found significantly decrease (P<0.01) in patient groups as compared with the control groups, and no significant increase or decrease in lipid profiles in comparison between patients groups (P ? 0.05).3. There is significant increase (P< 0.01) in RBP4 between patients and control groups, and not significant (P?0.05) difference between patient groups.4. Group M shows significant positive correlations (r = 0.514, p= 0.0012 and r = 0.536, p = 0.0034) of RBP4 concentration with serum fasting insulin concentration and HOMA - IR respectively, in group F, the results show a significantly positive correlation (r = 0.502, p = 0.001 and r = 0.474, p = 0.02) between RBP4 concentration with serum fasting insulin concentration and HOMA - IR respectively.5. A significant positive correlations was found (r = 0.486, p 0.001; r = 0.388, p 0.013; r =0.385, p=0.014) for serum RBP4 concentration with TC, TG and LDL - C concentrations respectively, and significantly negative with HDL - C (r = - 0.424, p =0.006) in group M, also positive correlation (r = 0.443, p =0.004; r = 0.467, p = 0.002; r = 0.435, p = 0.005) of RBP4 with TC, TG, LDL - C respectively and negatively with HDL - C (r = - 0.453, P = 0.003) in group F.6. A significant increase (< 0.01) in non HDL - C between patients and control groups and no significant (?0.05) difference between patient groups.7. According to the results of genotyping, XbaI polymorphism wasidentified as homologous genotype XbaI ( - / - ) were 12 (30%) in the group M, 14 (35%) in the group F, 3(7.5%) in the group MC and in the group FC 2(5%), while individuals have heterozygous genotype XbaI ( - /+) were 7 (17.5%) in the group M, 10 (25%) in the group F, 10 (25%) in group MC and in the group FC 8(20%).8. A significant association between the frequency of XbaI ( - / - ) variant in group M in compared with group MC an odd ratio = 5.14 and confidence interval at 95% level of (1.36 - 19.4), and in group F in compared with group FC an odds ratio = 13.12 and confidence interval at 95% of (2.64 - 65.07). 9. According to the results of genotyping, G894T polymorphism for eNOS gene was identified as homologous genotype TT were 7 (17.5%) in group M, 9 (22.5%) in group F, 8 (20%) in group MC and 10 (25%) in group FC, while individuals have heterozygous genotype G/T were 21 (52.5%) in group M, 20 (50%) in group F, 6 (15%) in group MC and 7 (17.5%) in group FC.10. A significant frequency of GT variant in group M is compared with group MC with odds ratio = 7.58 and confidence at 95% level of (2.43 - 23.62), and in patients of group F as compared with group FC with odds ratio = 7.27 and confidence interval at 95% of (2.4 - 22.02).In conclusion, the RBP4 is associated in causing insulin resistance and lipid abnormalities. The high levels of Non HDL - C in diabetic patient contribute in progression of diabetic nephropathy. The GLUT1 polymorphism in diabetic type 2 patients specially patients with XbaI ( - / - ) and eNOS gene polymorphism G/T allele have a role in progression to diabetic nephropathy.

دراسة الملف المصلي وتقييم بعض الخصائص المناعية لدى مرضى الحزام الناري Serum Profile Study And Evaluation Of Some Immune Features Among Patients With Shingles

اسم المؤلف: زينب عبد النبي طليفح النصراوي
اسم المشرف: حبيب صاحب نهر محمد كاظم طاهر الحطاب
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: جامعة بابل - كلية الطب - قسم الاحياء المجهرية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية للفترة من 1شباط 2015 لغاية 3شباط 2016 وجمعت خلالها عينات المرضى المصابين بالحزام الناري من قسم الامراض الجلدية في العيادات الاستشارية في مستشفى مرجان التعليمي للتحري عن بعض الجوانب المناعية في المرضى, وكان العدد الكلي للمرضى 50 مريضا | This study was conducted during the period from 1st February 2015 to 3rd February 2016, and the samples were collected from dermatology department of the consultant clinic in Marjan Teaching Hospital to investigate certain immunological markers of patients with shingles. The total number of patients were whose their ages ranges were 14 - 80 years. Age group (40 - 61) years have the highest percentage of infection reaching 46%.The immunofluorescence test for Varicella Zoster virus - specific IgG showed 48 out 50 are positive(96%). The higher percentage of infection with shingles was in female (54%), while male patients the percentage was(46%).The results showed that patients with blood group (O+) have 50% of infection rate.When CD4 was investigated by ELISA test , the results showed that the mean± SD of serum level of CD4 in shingles patients and control group is (6.70± 0.97 and 9.36±2.02) ng/ml respectively. The concentration of CD4 was lower in patients with shingles than healthy control group, while concentration of CD8 and CD56were higher than healthy control group ( the mean± SD of serum level of CD8 in shingles patients and control group was 21.42±5.43 and19.11±3.29 ng /ml respectively, whereas the mean ± SD of CD56 concentration in shingles and control group were 107.58± 40.39 and 67.59 ± 36.31 ng/ml, respectively).The results also showed that the concentrations of IFN ? and TNF? were lower in patients with shingles compared with non - infected persons , as the following : the mean± SD of serum level of IFN ? in shingles patients and control group was 184.31±21.95 and 218.03±26.21 pg /ml respectively, and the mean ± SD of TNF? concentration in shingles and control group were 51.55± 5.14 and 62.35 ± 6.74 pg/ml, respectively. For IL 10, the concentration was higher in patients with shingles than that in the healthy control group; the mean± SD of serum level of IL 10 in shingles patients and control group was12.42±5.59 and 4.47±0.90 pg /ml respectively. This study was concluded following : • Gender represents a risk factor for the occurrence of shingles mainly at ages over 40 years old (higher in females than males).• Varicella Zoster virus specific IgG is a sensitive and specific test that can be used for the laboratory diagnosis of shingles.• Varicella Zoster virus reactivation has a suggested link with decreased level of soluble CD4 molecules and, for lesser extend with increased soluble CD8 and CD56 molecules in patients serum. • Blood group O+ might be consider as a risk factor for reactivation of VZV infection as the majority of patients were within this blood group.• A diminished role of the inflammatory TH1 cells in reactivated shingles patients is more likely as evident by the reduced concentration of IFN? and TNF? profiles. The Treg cells (CD4+ CD25+) seems to play a role in such reduction of TH1 proinflammatory cytokines as evident by the significant elevation of IL10 in shingles patients.

قياس تركيز الحديد والفرتين والارثروبويتين وفيتامين ب وحامض الفولك والبيروكسايديز الدرقي في مصل مرضى تضخم الغدة الدرقية حديثي التشخيص في محافظة بابل Serum Iron,Ferritin,Thyroid Peroxidase ,B12,Erythropoietin And Folate Concentrations In Patients With Newly Diagnosed Hyperthyroidism In Babylon Province

اسم المؤلف: سالينا عبد العباس ناصر الشمري
اسم المشرف: محمد عبيد المحمدي علاء صادق العواد
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض - قسم الفسلجة والفيزياء الطبية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: فرط نشاط الغده الدرقيه : هو مرض يصيب الغده الدرقيه وذلك نظرا لارتفاع هرمون تي ثلاثه وتي اربعه وهما هرمونات الدرقيه ولوحظ ان هذا المرض يصيب النساء بنسبه اعلى من الرجال بسبب التاثير الهرموني للاناث مما يجعلها الاكثر عرضه لهذا المرض,من علامات هذا المرض هي زيا | Background : Hyperthyroidism is endocrine disease that occur due to high levels of thyroid gland hormones and this disease affected female more than male due to hormonal effect, the female is more susceptible to this disease.Sign of disease including increase in metabolic rate of patient,sweating,increase pulse,enlargement of thyroid gland(goiter) which by this sign can diagnosis the patient.Objective : Evaluate serum erythropoietin and its relation with increase metabolic rate as well as hemopoiesis,evaluate serum folic acid and vitamin B12 and its role in hyperthyroidism ,evaluate the correlation of thyroid peroxidase with thyroid hormones and evaluate serum iron and ferritin.Materials and methods : This study was done from October/2015 till July/2016.The total number of patients group in this study was seventy man and women.their age ranged 26 - 65 years,58 women and 12 men who was in patients group and 35 female and 5 male in control group.Patients data in this study was history of hypertension ,parity ,age and sex. The difficulty in my research was in collection of spa icemen from patients.Result : The result which obtained from this study found that high significant increase in ferritin,thyroid peroxidase,folate and erythropoietin (p?0.01) in patients as compare to control group.High significant decrease in iron and B12(p?0.01) in patients group compare to control group. in case of the age found the 30 - 39 years more effected age among patients group and the female more effected with disease than male.Conclusion : From this study we conclude that thehyperthyroidism in female more than male due to hormonal effect. Reduce in iron due to high metabolic rate lead to decrease absorption of iron and B12 which lead to anemia.increase thyroid peroxidase which play a role in T3 and T4 synthesis.

التزام مرضى احتشاء العضلة القلبية باتجاه العناية الذاتية في مستشفيات الحلة التعليمية Adherence Of Patients With Myocardial Infarction Toward Self - Care Management In Hillah Teaching Hospitals

اسم المؤلف: هادي جواد كاظم
اسم المشرف: سحر ادهم علي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: التمريض
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يمكن وصف العناية الذاتية كبرنامج متعدد الابعاد للمرضى الذين يعانون من احتشاء عضلة القلب والتي تشمل الامور المتعلقة بحالتهم وتعزيز استراتيجيات الرعاية الذاتية مثل المراقبة الذاتية والتصرفات الذاتية تحسين معرقة المريض الايجابية واستهلاك نظام غذائي صحي، الاد | Self - management can be described as multidimensional program for patients with myocardial infarctions which include improvement of the patient s knowledge related to their condition and enhance self - care management strategies such as self - monitoring, positive self - behaviors, and consumption of healthy diet, medication and following the health team advices. This strategies decrease hospital readmissions and improve quality of life. The aim of the study is assessing the adherence of self - care management among patients with myocardial infarction. To identify the demographical characteristics of the study sample such as (age, gender, marital status, educational status, and addressing, economic status). To find out the relationship between patient adherence of self - management and demographic data (age, gender, marital status, educational status, addressing, economic status) and clinical characteristics.Across - sectional descriptive design is used to carry out the study of assessing the adherence of the self - care management for patients with myocardial infarction in Hillah teaching hospitals from 27 - 10 - 2015 to 20 - 8 - 2016.Coronary care units and medical wards in two teaching hospitals in Hillah city were selected to conduct the study. A Non - Probability (purposive sample) of (100) patients, (64) male, (36) female have been selected after obtaining their agreements to participate in this study, these patients have been admitted to the medical wards or coronary care units. Data were collected by using structured questionnaire which prepared to assess the adherence of self - care management for patients with myocardial infarctions after a comprehensive review of related literatures. The questionnaire contains three parts, the first part consist data related to the socio - demographical characteristics of the sample, the second part includes clinical information such as (duration of disease, health history, body mass index...etc.), while the third part extends to collect the data related to the patients adherence toward self - care management which distributed up on (4) domains consisting nutritional domain (27) items, healthy behaviors (7) items, medications (8) items, medical follow up which has been extended to (9) items. Data have been collected by using face to face interview.To test the content validity the questionnaire distributed among (25) experts who have not less than 10 years of experience , the reliability was calculated through applying coefficient of correlation and inter rater reliability, descriptive and inferential statistics methods used to determine the results of the current study.The majority of the study sample have been (64%) male between (60 years and more) age group, (64) married, (22%) have been illiterate, (66%)of the sample urban area residency. housewives Most of them (25%) suffer from hypertension as a chronic disease. Overall adherences of the self - care management of the participant poor related to diet, healthy behaviors, follow up while they recorded moderate adherence related to consumption of medication.The majority of the patients who participate in the study were with moderate adherence relation to self - care management.Establishment of well - equipped rehabilitation center specialized to improve patient's knowledge and practices related to their conditions, and help them to live with their condition, the services of this center may be extended to serve patient's family.

اعباء رعاية الابوين للاطفال المصابين بالتخلف العقلي في محافظات الفرات الاوسط Parents Burden Of Care For Children With Mental Retardation In The Middle Euphrates Governorates

اسم المؤلف: علوان حسن رزن الجبوري
اسم المشرف: سجاء هاشم محمد الربيعي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: التمريض
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يمكن ان تسهم مسؤولية رعاية الاطفال المتخلفين عقليا في عبا على الوالدين, الدراسة تشير الى ان اباء الاطفال الذين يعانون من التخلف العقلي لديهم مستوى عال من العبء.دراسة تحليلية وصفيه لتقييم عبء رعاية الاباء للاطفال ذوي التخلف العقلي في محافظات الفرات الاوسط | The responsibility of caring for mentally retarded child can contribute to parents burden. The study shows that parents of children with mental retardation experience high level of burden.The present study aims to assess the level of burden of care among parents who have children with mental retardation.and to identify the relationship between parents burden of care for children with mental retardation and their sociodemographic data such as age, gender etc. A descriptive - analytical study design is conducted to assess the Parents Burden of Care For Children With Mental Retardation in The Middle Euphrates Governorates and its relation to children and parent's sociodemographic characteristics and clinical characteristic of mental retardation child.1st October 2015 to 1st October 2016. A purposive (non - probability) sample of (90) parents (mother or father) of child with mental retardation are selected attending mental disability care institute. Data was collected through the use of The questionnaire which are constructed by the researcher for the purpose of present study. In order to test the validity of the questionnaires, the instrument is presented to panel of experts in different fields to make it more valid. A preliminary copy of the questionnaire is displayed to (15) experts. Data have been analyzed by using descriptive and inferential statistics.The results of the study indicated that parents exhibit high level of burden due to the handicap caring among their children. There is a significant relationship between the levels of parents' burdens and their child handicap degree and the monthly income. As for the psychological status there are significant differences between the psychological burden and the parents level of education and residency. But there is non - significant statistical points between the parents burden and other parents demographical data.The study concludes that there is a high level of parents burden due to the presence of mental retardation child in the family and that effect on the family. The degree of mental retardation is very important indication about the level of the burden.It is recommended that future study researches should be directed towards exploring psychological intervention factors which help to minimize the burden of care on parents of children with mental retardation.

المشكلات النفسية الاجتماعية لدى كبار السن في دور رعاية المسنين في محافظات الفرات الاوسط Psychosocial Problems Among Elderly People At Geriatric Homes In The Middle Euphrates Governorates

اسم المؤلف: وسيم عبد الامير شاكر البصام
اسم المشرف: سجاء هاشم محمد الربيعي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: التمريض
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: اجريت دراسة وصفية تحليلية خلال المدة من الاول من تشرين الاول من عام 2015 الى تشرين الاول 2016 من اجل تقييم المشكلات النفسية الاجتماعية لدى كبار السن في دور رعاية المسنين في محافظات الفرات الاوسط.عينة غرضية (غير احتمالية) تتالف من (82) شخص مسن قد تم اختيا | Analytical descriptive study was conducted during the period of 1 October 2015 to October 2016 in order to assess the psychosocial problems among elderly people at geriatric homes in the Middle Euphrates Governorates. A purposive sample (non - probability) for (82) elderly people was selected from geriatric homes in the Middle Euphrates Governorates, information was gathered through the use of a questionnaire for assessing psychosocial problems, study tool consist of three parts which contain (53) items. Part one : The first part consists personal information and include age (year) , age at admission, residence years in geriatric homes, gender, previous professions, educational level, social status, economic status, financial support by family, the financial resources.Part two : The second part consists psychological problems (anxiety, depression and suicide ideation) which contains (35) item. Part three : The third part consists social problems (social isolation) which contains (12) item. Reliability is determined by using alpha correlation (Cronbach's Alpha) and the validity is achieved through a panel of (21) expert. Data analyzed through using the Statistical Package of Social Sciences SPSS (Version 20) performed through the use of descriptive statistical data analysis approach, of frequencies, percentages and inferential statistical approach which is presented as an analysis of variable chi - square.The findings of the study indicated that most of elderly people were suffering from psychosocial problems in moderate levels. The majority of the sample of elderly were in the age group (75 - 84) years and most of the elderly who spent in geriatric homes (1 - 4) years, males, divorced and uneducated. Results of the study showed the existence of a high significant relationship among the elderly who were uneducated and divorced which suffered from psychosocial problems.The study concluded that the psychosocial problems for elderly were in the age group (75 - 84) years and in moderate levels.The study recommended to improve care for elderly people and provide psycho educational programs for them to increase their knowledge toward the psychological problems and provide psychological support to improve their psychological status

الاهمية الكيميائية الحياتية لنبتة العليق الاحمر كماسك طبيعي في حالة زيادة الحديد Biochemical Importance Of Rubus Idaeus As A Natural Chelator In Iron Overload Status

اسم المؤلف: حازم علي حسين
اسم المشرف: مفيد جليل عوض مؤيد عمران الغزالي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: لمنع تراكم الحديد في الجسم، وخاصة لمرضى داء ترسب الاصبغة الدموية،او الذين يحتاجون الى نقل دم بصورة مستمرة، لابد من عمل مركب معه يعمل على استخراجه.نبتة العليق الاحمر تحتوي على كمية عالية من حامض التانيك وهو مركب متعدد الفينولات للنبات يعمل على مسك او حجز | To prevent iron overload, especially for those patient with hemochromatosis or those having chronic blood transfusion, iron must be chelated and excreted, Rubus Idaeus containing high quantity of tannic acid which is a plant polyphenol, chelate iron and excreted from the body. The present study aimed to evaluate the activity and efficiency of tannic acid in Rubus Idaeus fruit to reduce or eliminate iron overload through enhance direct impact on some of the body,s vital biological activities by using fresh crude plant as herbal medicine. This study is Cohort study designed. It is monitoring, detection, and investigation study that included some of groups that completely under control(control), and other group which induced iron overload , the iron overload group is subdivided to 5 groups, one of this sub gorups is treated with desferal(Deferroxamine),and the rest 3groups giving 3 different doses of pure fruit of Rubus Idaeus, while the least group is not treated with fruit or with desferalThe study included (60) Albino male mice divided into six groups with count (10) mice for each. First group was labeled as control (A). The other five groups received intra peritoneal injections of iron - dextran at a dose of 100 mg/kg/day B.w. (one dose every two days for 3 weeks) are the iron overload groups ,which are classified as a following : B1 group ,in which the iron overload induced mice treated with 100 mg/kg/day of Rubus Idaeus fruit, B2 group, in which the iron overload induced mice treated with 200 mg/kg/day of Rubus Idaeus fruit,B3 group ,in which the iron overload induced mice treated with 300 mg/kg/day of Rubus Idaeus fruit, group(C),in which the iron overload induced mice received 493mg/kg/day desferal by subcutaneous injection for 21 days beginning on the day following the first iron dextran injection, group (D) ,in which the iron overload induced mice neither received desferal nor Rubus Idaeus fruit. The experimental work was carried out in the animal house and in the Clinical Biochemistry Department / College of Medicine / Babylon University during the period from (October 2015 to August 2016). High - Performance Liquid Chromatography (HPLC) technique has been used for measurement of tannic acid in fruit in mice's serum. Enzyme Linked Immunosorbent Assay (ELISA) has been used for the measurement of serum ferritin, UV - Vis Spectrophotometer has been used for determination of GSH - Px and GST concentrations, while Graphite Furnace Atomic Absorption Spectrophotometer technique (GFAAS) has been used for concentration measurement of trace elements. There were hematological study have been carried out using special required equipment, protein analysis by electrophoresis has been used for mice's serum to detect protein changes for all groups. Results showed that Rubus Idaeus fruit contain good acceptable concentration of tannic acid up to (853 µg/gm),amount of trace element in the fruit plant was 14.12 ppm for Zinc,33.62 ppm for Iron,3.5ppm for copper(Cu),311.06 ppb for selenium(Se),40.13 ppb for chromium(Cr). Results also showed highly significant increase of Serum ferritin, hemoglobin levels, GST activity, Iron and Copper concentration, and decreased in chromium in iron overload group (D) (P<0.001) when compared with control group (A), while there were highly significant decrease of these parameters and increased chromium in group (B2) and group (C) as compared with control groups. Results also showed highly significant decrease of GSH - Px activity, Zinc and Selenium concentration, and increased in hemoglobin levels in group (D) (P<0.001) when compared with the control group, while there were highly significant increase of these parameters and decreased in hemoglobin level in group (B2) and (C)as compared with control and (A) groups. The study have been found positive effect of Rubus Idaeus on abnormal parameters and support the biological system which was clear in group (B2) and (C) which demonstrated that there were significant inhibitions to decrease or increase of these parameters than those in normal. The present study found that fruit of Rubus Idaeus in dose(200 mg/kg/day)in mouse(16.2mg/kg/day in human) gives more reasonable results than other 2 doses (100mg/kg,300mg/kg) in treatment of iron overload ,100mg/kg had no effect in reducing iron overload,300mg/kg chelate iron so more that causing anemia, while this study found a negative correlation between Ferritin and GSH - Px activity, serum chromium and Selenium concentration. Results also showed that there is a changes in protein bands in samples, new bands occurs in samples of induced iron overload group (D) due to increased production of iron regulating proteins. While these bands are absent in groups (A),(B2)

تقييم مضاعفات ما بعد العملية للمرضى الخاضعين لجراحة العظام في مستشفى الحلة التعليمي Assessment Of Postoperative Complications For Patients Undergoing Orthopedics Surgery At Al - Hilla Teaching Hospital

اسم المؤلف: احمد رامز هلال
اسم المشرف: فخرية جبر محيبس الزبيدي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: التمريض
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: الخلفية : مضاعفات ما بعد العملية تتعلق بنقص في العناية ما بعد العملية تقود الى عدة مضاعفات ربما تتطور في عدة مرضى نتيجة تاثير التخدير العام ومخاطر اخرى مثل طول فترة الرقود في المستشفى، عدم الحركة بعد العملية، التدخين, 000 الخ. كل عوامل الخطورة ربما تؤدي ال | Background : Postoperative complication is a source of concern as insufficient postoperative care leads to many complications which may develop in many patients due to the effect of general anesthesia and other risk factors such as prolonged hospitalization, immobilization after surgery, smoking, …etc. All risk factors may lead to postoperative complications, thus they impose additional economic burdens on the society and the patient.Objectives : The purpose of this study was to assess the postoperative complications in patients undergoing orthopedic surgery and to find out relationship between socio - demographic characteristics, medical information and postoperative complications such as (age, gender, smoking, medication, …etc.). Methodology : The study was carried out from 25 January 2016 to the 30 November 2016, the sample was Non probability sample which consists of (100) adults patients (male and female) who were undergoing orthopedic surgery with lower and upper extremities' under general anesthesia, without chronic disease and age of patients 18 years older at Al - Hilla Teaching Hospital.To achieve the objectives of the study, the researcher established the questionnaire format which was composed of three - part, part one : socio - demographic characteristic (5) items, while part two : consisted of medical information of patients which comprised of (7) items and part three : consisted of (34) items of postoperative complications may happen postoperatively.Results : The results of this study indicated that a high percent of postoperative complications occurred in ages between (18 - 27)years. The study also revealed the highest percentage (38%) of patients were smokers who had high complications. In addition the current study founded that smoking appears to decrease postoperative vomiting rate in smoker (16.2 %) less than non - smoker (36.7 %). The rate of vomiting in female (60%) is more than male (22.3 %). in addition the rate of infection in Smoker (11.6 %) more than non - smoker (1.7%). Total score of complications indicated the significant relationship between socio - demographic characteristics, medical information and postoperative complications like (age, smoking, occupation, education level, and medications used) as it is proved by chi - square tests. Recommendations : According to the current study, the researcher recommends to Increase knowledge of nursing staff regarding postoperative complications by continuing education , so the nurses can identify and prevent postoperative complication.Increase knowledge of patients regarding postoperative complications through provide them by advices or list in which is containing information or pictures that occur in patients with orthopedics surgery such as deep vein thrombosis, wound infection, and how to prevent them.

تقييم الحالة التغذوية للاطفال دون سن الخامسة من العمر في مدينة الحلة Assessment Of Nutritional Status Among Children Less Than 5 Years Old In Al - Hilla City

اسم المؤلف: اسماعيل حسن جواد الموسوي
اسم المشرف: قحطان هادي حسين الجبوري حسن علوان بيعي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: التمريض
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: اجريت دراسة مقطعية وصفية خلال الفترة من 1 تشرين الاول 2015 الى 27 اب 2016 لاجل تقييم الحالة التغذوية للاطفال دون الخامسة من العمر في مدينة الحله من خلال قياس (الوزن للطول والعمر) من خلال المقاييس الجسمانية, وكذلك لايجاد العلاقة ما بين الخصائص الديموغرافية

دراسة انزيم التيلومريز وجين الكلوتاثيون بيروكسيديز الاول في مرضى السكري النوع الاول Telomerase Enzyme And Glutathione Peroxidase1 Gene In Type 1 Diabetes Mellitus Patients

اسم المؤلف: دعاء مهدي هادي الحكاك
اسم المشرف: مها فاضل سميسم علي حسين البياتي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: Type 1 diabetes is characterized by an immune - mediated depletion of ? - cells that results in lifelong dependence on exogenous insulin. Accumulating evidence suggests that oxidative cell injury caused by free radicals contributes to the development of type 1 diabetes mellitus (T1DM) complications and decreased efficiency of antioxidant defenses (both enzymatic and nonenzymatic) seems to correlate with the severity of pathological tissue changes in T1DM, So many studies have tended to analyze the genetic material that can be related to the occurrence of the disease. Different combinations of genetic defects of antioxidant enzyme are expected. This could readily provide an explanation of the heterogeneity of T1DM.The aim of this study is to assess the differences of GPX1 genotype in T1DM as compare with controls. And the effect of C/T at nucleotide 1050450codon 198 of GPX1 gene polymorphisms on serum glutathione peroxidase (GPX) and telomerase enzyme (TE) concentration in T1DM patients and controls. This study included (108) persons, their ages between (28 - 42 years) and body mass index in normal and overweight (68) of them were uncontrolled diabetes type 1 (HbA1c ? 6.5 %), (34) of them were male patients (M group), the other (34) were female patients (F group), and the other (40) apparently healthy as control group (20) male (MC group) with (20) female (FC group). The sera sample of all groups were used to measure the concentration of fasting blood glucose by using colorimetric methods and ELISA method for determination (TE), total antioxidant capacity (TAO - C), glutathione (GSH), and glutathione peroxidase1 enzyme, while whole blood samples from study subjects were used to measure HbA1c and extract DNA for the study of polymorphisms in GPx1 gene.The results of the present study showed1 - A significant increase in glucose, HbA1c in both male and female patients compared with controls group. (P < 0.0001) and (p< 0.05) respectively.2 - The study showed significant decrease (p? 0.001) in telomerase enzyme in both M and F as compare with MC and FC groups,3 - There was no significant association between M and F (P=0.106) and between MC and FC (P=0.327) regarding to gender.4 - The result showed that telomerase concentration significantly decrease with age (p - value<0.001) which indicated by negative correlation between telomerase concentration and age.5 - The result showed significant negative correlation between telomerase enzyme concentration and BMI in patients and controls.6 - The result showed significant decrease in TAO - C in patient as compared with control groups (P=<0.001)7 - GPX1 concentration significantly decreased in patient as compared with control groups (p - value <0.001 )8 - Significant increase in Glutathione concentration in patients as compared with controls (p - value <0.05)9 - Data on the genetic patterns were analyzed using polymerase chain reaction technique - RFLP revealed, were defined as : the codon 198 of Gpx1 genotyping have the homozygous wild - type (CC) Pro/Pro, the homozygous mutant (TT) Leu/Leu, and heterozygous (CT) Pro/Leu allele. There was significant difference between genotype distribution and frequency of alleles between the two groups of patients (M and F) versus (MC and FC) (odds ratio = 33, into confidence level of 95% : 1.65 to 656.26) and P value ( 0.0219) for M vs. MC, and (OR = 12.60, into the proportion of 95% confidence level : 1.93 to 82.08) and P value (0.0081) for F vs. FC. Also, the frequency of TT genotypes in GPX1gene in male and female were47% and 61.7% compare to control male(0%) and female(10%).10 - The allele frequency showed significant differences in all sample (p=0.0013), in male (0.14) and in female (0.0020).11 - There was significant difference in telomerase concentration (p= 0.001) and in glutathione peroxidase concentration (p< 0.0005) in patients group depending on different of the GPX1 genotyping.12 - Depending on GPX1 genotype there were significant differences in BMI in normal weight and in overweight between patient and control (p=0.0375) and (p<0.0018), respectively.In Conclusion, the TT genotype of The GPX1gene variants Pro 198 Leu may be risk factor to T1DM patients. TIDM significantly associated with glutathione peroxidase and telomerase level in patients with TT genotypes of GPX1 gene compared to those with CT and CC genotypes, and this may be considered as a risk factor for senescence and mortality in T1DM. patients, also there is significant negative correlation between telomerase enzyme and BMI in patients and controls.

التغيرات الحاصلة في نسب الانسولين والاحماض الصفراء والكوليسترول 7 الفا هيدروكسليز وفوق الاكسيد الفائق في مصل مرضى حصى المراره Serum Insulin, Bile Acid, Cholesterol 7 - Alpha Hydroxylase And Superoxide Dismutase Changes In Patients With Gallstone

اسم المؤلف: سماح سجاد كاظم الشمري
اسم المشرف: محمد عبيد المحمدي علي خير الله الشاعلي
الموضوع العام: الطب
السنة: 2017
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية الطب - قسم الفسلجة والفيزياء الطبية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: يعتبر مرض حصى المرارةمن اكثر امراض الجهاز الهضمي شيوعا، ووتشكل عبئا كبيرا على انظمة الرعاية الصحية. معظم الناس (حوالي 80 ?) مع حصى المرارة ليس لديهم اعراض. وتشمل مضاعفات حصى المرارة التهاب المرارة والبنكرياس.الهدف من الدراسة : 1 - للتحقيق في العلاقة بين | A gallstone is a stone formed within the gallbladder out of bile components. Cholelithiasis or Gallstone disease (GD) is one of the most prevalent gastrointestinal diseases, with a substantial burden to health care systems. Most people (about 80%) with gallstones are asymptomatic. Complications of gallstones include inflammation of the gallbladder, pancreas. Objective 1. To investigate the association between serum level bile acid and cholesterol 7 - alpha hydroxylase and the development of gallstone disease. 2. To Evaluate the change serum level insulin changes and its effect on gallstone formation. 3. The determination of serum superoxide dismutase changes in patients with gallstone. Material and Methods In this study, one hundred sixty (160) patients with gallstone aged (20 - 70) years and one hundred sixty (160) age and sex match subject (control group) had involved in this study. The patients were intended to undergo surgical removal of gallbladder in Al - Hilla general teaching hospital during the period from November (2015) to May (2016). Blood samples were obtained from all patients prior to surgical treatment. Serum was obtained by usual methods and analyzed for insulin, insulin resistance Cholesterol 7 - alpha hydroxylase, Superoxide Dismutase, Bile acid (Deoxycholic acid and Chenodeoxycholic acid) and lipid profile {total cholesterol, triglyceride, high density lipoprotein - cholesterol and low density lipoprotein cholesterol}. And qualitative analysis of gallstone (Cholesterol stone, mixed stone, pigment stone), then these parameters compared with those of control groups. In addition, a demographic comparison regarding to the age, sex and body mass index between the patients and control groups was carried. Results The results of this study show higher significant percentage of gall stone in female (81%) than male (19%) in the patient group. There was an insignificant difference between male and female patients, according to age group (P<0.05). There is a higher significant (p>0.05) family history in the patients with gallstone compared with control subjects. Additionally, There is highly significant percent of female using oral contraception in pateints than control group (p > 0.01). Similarly, smoking, parity,Type 2 diabetes mellitus and Body Mass Index are found to be significantly higher inpatient group (p>0.01). This study demonstrate that insulin and insulin resistance are significant higher in sera of patients with gallstone as compared with the control group. (p>0.01) Regarding the cholesterol 7 - alpha hydroxylase, superoxide dismutase and Bile acids are found to be significantlylower in sera of patients with gallstone as compared with the control group, p< 0.01). It has also found that there are a higher significant difference in gallstone patients than control regarding total cholesterol, triglyceride, high density lipoprotein - cholesterol and low density lipoprotein cholesterol levels were significantly higher than that of control group (p>0.01). Meanwhile, all these parameters in the study are variated according to gender. However The qualitative analysis of stone that show cholesterol stone is more common than other types.Conclusions In this study the most studied parameters including of Insulin and insulin resistance, cholesterol 7 - alpha hydroxylase, superoxide dismutase and Bile acids, cholesterol, triglyceride, high density lipoprotein - cholesterol and low density lipoprotein cholesterol are significantly different in gallstone patients compared to control subjects and such differences are demographically affected depending on the age, sex, BMI, parity, contraceptive and smoking.

Effect Of SNP rs198389 of BNP Gene On The Natriuretic Peptides Levels In Cardiovascular Patients

اسم المؤلف: Alaa Salman Idan Al - Ibrahimi
اسم المشرف: Monem M. Al shok Moaed E. Al Gazally
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: Acute coronary syndrome (ACS) refers to any group of acute signs and symptoms attributed to sever obstruction of the coronary arteries. Acute coronary syndrome usually occurs because of one of three problems : ST elevation myocardial infarction, non - ST elevation myocardial infarction, and unstable angina. These types are named according to the results of the electrocardiogram (ECG). In addition to clinical and electrocardiogram (ECG) findings, several biochemical markers are considered in patients with chest pain to diagnose myocardial ischemia. Heart failure (HF) according to American College of Cardiology (ACC) and American Heart Association (AHA) is a complex clinical syndrome that can be caused by any structural or functional disorder in the heart that fails the capability of the ventricle to fill with or to eject blood. The diagnosis is often performed clinically on the basis of the presence of dyspnea, fatigue, signs of fluid overload, such as pulmonary crepitation, peripheral edema, and distension of jugular vein.B - type natriuretic peptide (BNP) and N - terminal pro - BNP (NT - proBNP) are secreted by human atrial and ventricular myocardium. The rise in BNP and NT - proBNP levels after ACS and HF correlates with infarct size and regional wall motion abnormalities. Echocardiography remains the most frequently used and usually the initial imaging test to evaluate all cardiovascular diseases related to a structural, functional, or hemodynamic abnormality of the heart or great vessels. This study is designed to investigate and assess the serum concentrations of BNP and NT - proBNP in patients with HF and ACS; In addition, almost equal number of males and females are chosen to control the effect of age and gender on the levels of BNP and NT - proBNP. Also, the study aims to evaluate the effect of BNP gene T - 381C (rs198389) polymorphism on the plasma human levels of BNP and NT - proBNP and compare the results that will obtain with healthy control.The present study was involved (70) patients, (35) of them with ACS and the other (35) with HF. The study also includes (22) subjects were taken as control group. The sera obtained from the blood of patients and control subjects were used to measure the concentrations of BNP and NT - proBNP, while whole blood samples from study subjects are used to extract DNA for the study of polymorphism in BNP gene.The results indicate both the ACS and HF groups have significantly higher levels of BNP and NT - proBNP when compared to control group, also HF patients have higher levels of both parameters than ACS patients, in all comparison (p

المستويات والانماط الجينية المتعددة للانترلوكين - 6 في مرضى التهاب المفاصل الرثوي في محافظة بابل/العراق Interleukin - 6 Gene Polymorphisms And Levels In Rheumatoid Arthritis Patients In Babylon Province / Iraq

اسم المؤلف: سارة حسين عيدان
اسم المشرف: عبد السميع حسن الطائي صباح جاسم الربيعي
الموضوع العام: الطب
السنة: 2011
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بابل
الصفحات الاولى:
المستخلص: التهاب المفاصل الرثوي هو احد الامراض المناعية الذاتية الالتهابية المزمنة الذي يتميز بالتهاب المفاصل المتماثل المستمر الذي يصيب عادة مفاصل اليدين والقدمين.تهدف هذه الدراسة الى التقصي عن العلاقة المحتملة بين مستويات الانترلوكين - 6 والانماط الجينية المتعددة | Rheumatoid arthritis (RA) is a chronic systemic inflammatory, autoimmune disease characterized by persistent symmetric polyarthritis that commonly affects joints of hands and feet.This study aims to investigate the possible association between interleukin - 6 (IL - 6) levels and ( - 174 G/C) IL - 6 promoter polymorphism in RA in Babylon Province. 60 RA patients and 60 healthy controls matched in age and sex were included in this case control study. Measurement of serum IL - 6 and serum anti cyclic citrullinated peptide (ACCP) antibodies were assayed using commercially available ELISA kit. Measurement of blood rheumatoid factor (RF) was assayed by use slide agglutination test for the qualitative and semiquantitative. Whereas, blood C - reactive protein (CRP) was determined using latex - enhanced nephelometry. Disease severity score of RA patients was determined by use DAS - 28. DNA was isolated from white blood cells (WBCs) and ( - 174 G/C) IL - 6 gene promoter polymorphism was determined by polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) technique. the study was found significantly high levels of serum IL - 6 and ACCPA in untreated and in treated RA patients when compared to healthy controls. RF of patients with RA in the present study was found to be positive in 83.32% and negative in 16.67 % in overall RA patients, whereas was negative in 99% of healthy control. CRF of patients with RA in the present study was found to be positive in 78.4% and negative in 21.6 % in overall patients with RA, and was positive in 20% of healthy control. Correlation between DAS - 28 and IL - 6 levels in untreated and in treated RA patients were significant positive correlation. Correlation between IL - 6 and ACCPA in untreated and in treated RA patients were significant positive correlation. Correlation between DAS - 28 and ACCPA in untreated and in treated RA patients were significant positive correlation. The Genotype of ( - 174 G/C) IL - 6 gene promoter polymorphism and its percentage in patient found to be 80% GG,18.3% GC and 1.6% CC, whereas in healthy control 98.3% GG, 1.6% GC and 0% CC. Relation between both of IL - 6 levels and DAS - 28 with genotyping of ( - 174 G/C) IL - 6 gene promoter polymorphism in untreated and treated RA patients were found to be positive significant relation. The high levels of IL - 6, and its positive relation with DAS - 28 may suggest a possible role of IL - 6 in the pathogenesis of RA. Moreover, these biomarkers can be used as markers of disease activity in the diagnosis and treatment of RA. ( - 174G/C) IL - 6 polymorphisms are also associated with the RA risk, and the C allele of IL - 6 promoter polymorphisms has dramatically increased the susceptibility of RA in Babylon population. This finding suggests that the ( - 174 G/C) IL - 6 gene promoter polymorphism may also be used as another genetic marker for the onset and development of RA in Babylon population.

اكتفين ا كعلامة بيولوجية للحمل خارج الرحم والاجهاض المنسي Activin A As A Biomarker For Ectopic Pregnancy And Missed Abortion

اسم المؤلف: مي حامد حسن
اسم المشرف: نورهان شاكر
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: النسائية والتوليد
الدرجة: دبلوم عالي
الجامعة: جامعة الكوفة - كلية الطب - قسم النسائية والتوليد
اللغة: الانكليزية
مكان الجامعة: النجف
الصفحات الاولى:
المستخلص: Background : Activin A is a member of transforming growth factor B family that is secreted from ovary and placenta, however, in pregnancy the main source is the trophoblast.Aim of study : Activin A measurement to differentiate between intrauterine pregnancy and failed (missed abortion and ectopic) pregnancies.Study design : a Case control study.Setting : Department of Obstetrics and Gynecology in the College of Medicine Kufa University in Al Zahraa Teaching Hospital.Material and Methods : This study is a case control study consisting of 90 patients on three groups : Group 1 ectopic pregnancies (EP) (n=30) , Group 2 missed abortions (MA) (n=30) and Group 3 healthy viable intrauterine pregnancies (IUP) (n=30) were came to hospital with lower abdominal pain and\or vaginal bleeding or both between 6 - 8 weeks of gestation. Serum samples were sent at initial visit before treatment for measurement of activin A using ELISA test.Results : Activin A concentrations were significantly lower in women with EP (n = 30, mean value of 89.9 pg/mL) and women with MA (n = 30, mean value of 164.9 pg/mL) compared to IUP (n = 30, mean value of 334.5pg/mL); P < 0.001. Activin A can discriminate an ectopic pregnancy from viable pregnancies also, it was able to discriminate a MA from an EP.Conclusion : In this study activin A could be considered a promising biomarker for the discrimination between an IUP and a failed pregnancy (MA or EP).

مستوى مصل الدم للهرمون مضاد مولر AMH كاداة تشخيصية للاستجابة لتحريض الاباضة في مرضى متلازمة المبيض المتعدد الكيسات PCOS Serum Level Of AMH As A Prognostic Tool For Response To Ovulation Induction In Pcos Patients

اسم المؤلف: فرح حسام الدين سعران
اسم المشرف: صالحة علي حسين بتول عبد الواحد
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: النسائية والتوليد
الدرجة: دبلوم عالي
الجامعة: جامعة الكوفة - كلية الطب - قسم النسائية والتوليد
اللغة: الانكليزية
مكان الجامعة: النجف
الصفحات الاولى:
المستخلص: متلازمة المبيض المتعدد الكيسات (PCOS) هواضطراب شائع جدا التي تحدث في 4? الى 7? من النساء في سن الانجاب. من المعروف انPCOSغالبا ما يترافق مع الاصابة بالامراض التناسلية وزيادة خطرالاصابة بسرطان بطانة الرحم،والتشخيص له اهمية خاصة لانه يعتقد الان بانPCOS له ا | From the observation that some PCOS patients were known to have high serum level AMH and it has been shown to be useful in its diagnosis, however; the clinical significance of high serum AMH level in prediction of ovarian response to medical therapy was under studied we are doing this study aiming to test the value of serum AMH level as a marker of sever disease and may be subsequent resistance to medical therapy. (AMH) has glycoprotein dimmer structure.AMH is produced by the granulose cells. AMH level in the plasma of PCOS patient are two or three times higher than average and begin to decline five years later than healthy womenObjectivesThe main objective of the study is to estimate the AMH level as a prognostic factor in PCOS infertile women on ovulation induction, also to describe some risk factors of infertility and their association with the AMH level.MethodologyA cross sectional study has been carried out in the outpatient clinic at Al Sadr infertility center under supervision of specialist gynecologist on 60 patients. The data has been collected by a questionnaire which contains demographic characteristics, gynecological history, physical examination and some laboratory investigations. The data collected by simple random to select the case from the outpatient clinics in the fact of 4 - 5 infertile women one day/week, then a period of time required for following up them after the ovulation induction The data have been collected during the period from the 1st of February till the 30 of September 2015.ResultsThere was a high statistically significant difference (P 0.000) in mean AMH among the cases with negative PT from those with positive PT, also the higher level of AMH strongly linked (P 0.023) with the presence of acne as a symptom of PCOS. There was no correlation of AMH with the age, LH, FSH, prolactin, TSH, size of dominant follicle and infertility duration. While it was positively correlated (P 0.000) with the age of menarche, BMI (P 0.000), Serum testosterone (P 0.002) andendometrial thickness (P 0.000).Conclusions & RecommendationsAMH is a useful test to study folliculogenesis and ovarian potential in various situations of infertility and for identification of PCOS. High levels of AMH are commonly associated with pregnancy failure.So, a recommendation of AMH level measuring for all PCOS patients should be done in order to know the prognosis during the ovulation induction.

العلاقة بين البروتين التفاعلي عالي الدقة في حالات سمدمية الحمل مع او بدون تخلف نمو الجنين Associationbetween Highly Sensitive C - Reactive Protein Level In Cases Of Preeclampsia With Or Without Intrauterine - Growth Restriction

اسم المؤلف: روسم جاسم محمد
اسم المشرف: الاء محمد صادق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: النسائية والتوليد
الدرجة: دبلوم عالي
الجامعة: جامعة الكوفة - كلية الطب - قسم النسائية والتوليد
اللغة: الانكليزية
مكان الجامعة: النجف
الكلمات الدلالية:
  • العلاقة بين البروتين التفاعلي عالي الدقة في حالات سمدمية الحمل مع او بدون تخلف نمو الجنين
الصفحات الاولى:
المستخلص: سمدم?ةالحملھوخلل?ص?بتقر?با 4% منالنساءاثناءالحملوتترتبعل?ھمخاطركث?رةبالنسبةل?موالطفل. نعرفتسممالحملعللىانھا?صابةالحد?ثةغ?رالمسبوقةبارتفاعضغطالدماثناءالحملبعدا?سبوع 20 منالحملوالمصحوبةبوجودبروت?نفيالبول.البروت?نالتفاعليعاليالدقةھومؤشرك?م?ائيبامكانناق?اسھف | Preeclampsia is a hypertensive disorder that affects 4% of pregnant women , in which the exact cause cannot identified it is one of the major causes of maternal and fetal morbidity and mortality as it causes death of more than 6300 women annually , also it puts a burden on perinatal outcome as prematurity and Intrauterine growth restriction.Continuous search for predictive markers of severe PE is important and can be used to target high risk women for effective preventive treatment.Aim of study : to evaluate that Highly Sensitive C - Reactive Protein can be used as maker for severity of PE and whether it can be used to predict development of Intrauterine growth restrictionPatients and methods : this is convenient a cross - sectional study includes 80 pregnant women with their age 18 - 35 years , their gestational age 32 - 40 weeks , admitted to AL - Zahraa teaching hospital , whose diagnosed as PE based on BP and proteinurea. Full history and clinical examination were performed, venous blood aspirated for each women for biochemical analysis, Liver functions tests, Renal function tests Highly Sensitive C - Reactive Protein, and Doppler ultrasound.Results : The patients divided into those with mild PE and severe PE, with or without IUGR. No significant difference between the level of hsCRP and the severity of PE as p value was(0.779), but there is significant difference between the presence of IUGR and the level of hsCRP when it is 2mg/L as the p value was(0.020).Conclusion : We conclude that s.hsCRP is not sign

دراسة علاقة طول عنق الرحم المقاس بالسونار الداخلي مزامنة مع كمية السائل الامنيوسي في توقع وقت حدوث الولادة المبكرة خلال سبعة ايام من تمزق غشاء السائل الامنيوسي المبكر Transvaginal Cervical Length & Amniotic Fluid Index : Can They Predict Delivery Latency Following Preterm Premature Rupture Of Membrane

اسم المؤلف: وسن غائب حسون غائب
اسم المشرف: امال منير مبارك
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: النسائية والتوليد
الدرجة: دبلوم عالي
الجامعة: جامعة الكوفة - كلية الطب - قسم النسائية والتوليد
اللغة: الانكليزية
مكان الجامعة: النجف
الكلمات الدلالية:
  • علاقه طول عنق الرحم المقاس بالسونار الداخلي مزامنة مع كمية السائل الامنيوسي في توقع حدوث الولادة المبكرة خلال سبعة ايام من تمزق غشاء السائل الامنيوسي المبكر
الصفحات الاولى:
المستخلص: توقع حدوث الولادة عند الحوامل المصابات بتمزق غشاء السائل الامنيوسي المبكريساعد الحامل على تهيئه نفسها لدخول المستشفى لاجراء اللازم لها واعطاءالجرعةالمنشطةلرئة الطفل وادخاله الى وحده العناية المركزة لحديثي الولادة.هدف الدراسة : تهدف الدراسة الى قياس طول عن | Patients with PPROM are often hospitalized for a prolonged period of time and deliver premature infants who frequently require neonatal intensive care. These women and their infants contribute significantly to obstetric &neonatal health care costs. The prediction of delivery latency could help direct the need for specific interventions such as hospitalization, intensive monitoring, timing of antenatal steroids.Objective : To determine whether transvaginal CL, AFI,or a combination of both can predict delivery latency within 7 days in women presenting with PPROM.Methods and Study Design : This was a prospective observational study of TVCL measurements in 80 singleton pregnancies with PPROM between 24 - 34 weeks. Transvaginal ultrasonography was performed with TOSHIBA SSA - 340A(Tokyo - Japan) apparatus 7.5MHz transvaginal probe, to measure the CL&AFI. Delivery latency was defined as the period from the initial TVCL after PPROM to delivery of the baby with our primary outcome being delivery within 7 days of TVCL. The independent predictability of significant characteristics for delivery within 7 days was determined using multiple logistic regression.Sensitivity, specificity, and predictive values were used to determin, whether the presence of a short TVCL, AFI or a combination of both affected the risk of delivery within 7 days.Result : Our study in women with PPROM show the validity of CL in predicting labor when the cut off value2cm the sensitivity=52.6%, specificity=69%, PPV=60.6%, NPV =61.7% and Accuracy=61.25%.The validity of AFI when the cut off value 5cm the sensitivity=71.1%, specificity=50%, PPV=56.3%, NPV=65.6% and Accuracy=60%.With combination of CL&AFI in predicting time of labor after PPROM the sensitivity=50%, specificity=92.8%, PPV=86.4%, NPV=67.2% and Accuracy 72.5%.In women with PPROM the rate of gestational age ? 30 weeks that labored within 7 days 44.7% and those labored more than 7 days 55.3%.Also the rate of gestational age >30 weeks that delivered within and after 7 days are 50%.According to the parity we found the mean value of those delivered within 7 days are 1.24 and those after 7 days are 1.28.Conclusion : Our study shows there is increase in positive predictive value when combination of AFI and CL in prediction of time of labour so women with AFI?5 and CL?2 had 86.4% risk of delivery within 7 days after PPROM. Also the study found there was no significant association between gestational age, or parity with the prediction time of labor.

نسبة حدوث النزف بعد الولادة في حالات الولادات الطبيعية, الاصطناعية, القيصرية الطارئة والغير طارئة في مستشفى الزهراء التعليمي لسنه 2015 The Incidence Of Postpartum Hemorrhage After Spontaneous And Induced Vaginal Delivery Versus Elective And Emergency Caesarian Section At Al - Zahraa Teaching Hospital In 2015

اسم المؤلف: اسراء علي عباس
اسم المشرف: ازهار موسى الطريحي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: النسائية والتوليد
الدرجة: دبلوم عالي
الجامعة: جامعة الكوفة - كلية الطب - قسم النسائية والتوليد
اللغة: الانكليزية
مكان الجامعة: النجف
الكلمات الدلالية:
  • حدوث النزف بعد الولاده في حالات الولادات الطبيعيه
  • الاصطناعيه
  • القيصريهالطارئه والغير طارئه في مستشفى الزهراء التعليمي لسنه
الصفحات الاولى:
المستخلص: خلال هذا البحث تم رصد حدوث النزف المهبلي بعد الولاده ومقارنته بين اربع مجاميع من المريضات اللاتي دخلن الى مستشفى الزهراء التعليمي من فتره الثاني من اذار الى الثاني من اب وكان عدد المريضات 9674 مريضه وكان عدد الولادات الطبيعيه 6137 منها 1352 كان عن طريق تح | The labour records of the patients admitted to the labour word and obstetrics word and theater in Al Zahra teaching hospital (9674 patients) during period of 5 months from 2nd of March to the 2nd of August, consequence study to compare the incidence of postpartum haemorrhage after : 1 - Spontaneous labour2 - Induced labour 3 - Elective caesarian section4 - Emergency caesarian sectionObjective : To compare the incidence of haemorrhage and risk factors among certain group of patients and to discover which group is more liable to develop PPH.Study design : Cross sectional studyMethodology : Estimating the blood loss for assessment of PPH by gravimetric method and collection of soaked packs method, evaluate the severity of bleeding and put the women in the proper PPH category to do the proper management plans.Finding and conclusion : The finding of our research is the incidence of PPH is 1.64% among all types of labour (159 patients had PPH during this period) and the main risk factor for PPH in study is the primigravidas in induced or augmented labour.Practical implication : These finding indicate that PPH is another complication of induction that needed to be taken into account when induction in being considered

مستخلصات الشاي تاثيرها الذاتي او الاضافي على حياة خلايا السرطان : دراسة داخل وخارج الانبوب Herbal Tea : Its Own Or Additive Effect On The Survival Of Cancer Cell Line : An In Vitro And Ex Vivo Study

اسم المؤلف: هدى غسان حميد
اسم المشرف: مروان صالح النمر ناهي يوسف ياسين
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت هذه الدراسة في فرع الفارماكولوجي في كلية الطب في الجامعة المستنصرية بالتعاون مع مركز ابحاث السرطان والوراثة\الجامعةالمستنصرية خلال الفترة من شهر كانون الثاني - شهراب لسنة 2014. الدراسة اقرت من قبل مجلس كلية الطب. صممت هذه الدراسة لتوضيح فعالية نبات ا | This study was conducted in the Department of Pharmacology at College of Medicine with incorporation of the Iraqi Center for Cancer and Medical Genetic Research at Al - Mustansiriya University, Baghdad, Iraq during 2014. This study was designed to elucidate the anti - cancer effect of Camellia sinensis by using four types of tea (black, green, white and oolong). Two experimental cancer models applied in this study; cancer cell lines (In vitro) and mice - bearing tumor (ex vivo). Several methodological and extracted aqueous and organic solvents were used to extract the tea. Microwave assisted extraction using distilled water as a solvent is applied in this study as the yield of bioactive substances are higher than other methods and organic solvents. The antioxidant activity was evaluated through the quantification of total flavonoids, total polyphenolic compound (bioflavanoids), total flavonols, reducing power, and proanthocyanidines. The scavenging property against reactive nitrogen species also was studied. The result showed that the different tea types contain approximately the same quantity of phenolic compounds; the only significant difference was in the proanthocyanidins level, which is a class of flavanols, found in high quantity in green tea compared with other tea extracts. Moreover, a significant scavenging property of peroxynitrite radical observed with all tea extracts. The extracts of black, green and oolong tea prevented or halted nitric oxide generation whereas the white extract tea promoted its generation, that is, a nitric oxide donor. The in vitro cytotoxic activity of Camellia sinensis in form of black, green, white and oolong tea was evaluated against four different types of cell lines. These are the AMN3 mammary cell carcinoma, Rhabdomyosarcoma, HeLa cells and Rat embryo fibroblast cells). The results showed greater effect of green and black tea over white tea and oolong tea against mammary cell carcinoma while the results of rhabdomyosarcoma cell line, which is an aggressive cancer cell, revealed a significant inhibitory effect of the growth of these cells by white and oolong tea extracts. All four types show almost equal percent of growth inhibition on HeLa cell line with the white tea been the most significant. A significant inhibitory effect of all tea extracts against the growth of rat embryo fibroblast cells indicated that the cytotoxic effect of the Camellia sinensis extended to normal cells and not specific to cancer cell. In addition, the antitumor effect of tea extracts was investigated (ex vivo) on BALB - c mice bearing - tumor. The volume, shape and color of the tumor masses were examined, in addition to measurement of the tissue malondialdehyde level as a biomarker of the lipid peroxidation, total tumor protein measurement and a histopathological study were done. The white tea showed antitumor effect by attenuating all the biomarkers of tumorogenesis. Herbal tea extracts induced DNA damage in term of separation the double strands molecule of calf thymus double stands DNA and human genomic DNA which may partly explained anti - cancer effect. We concluded that white tea extract is a promising nutrient that ameliorates the histopathological changes in mice bearing mammary tumor via generation reactive oxygen species by the evidence of activation lipid peroxidation process. Camellia sinensis plant can induce non harmful effect on DNA

تاثير كل من عقار الروزوفاستاتين وعقار الاتورفاستاتين على مؤشرات نسب السكر المصاحبة للسمنة المحدثة في الفئران Effects Of Atorvastatin Versus Rosuvastatin On Glycaemic Indices In Diet Induced Obese Mice

اسم المؤلف: نورس لطيف وهاب
اسم المشرف: علي اسماعيل عبد الله محمد حيدر مطير القريشي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Numerous interventional cardiovascular disease outcome studies have resulted in statins being an essential factor of cardiovascular primary and secondary prevention strategies.In recent years there was ahigh concern that statin use is associated with diabetes new onset which is strong, independent risk factor for cardiovascular (CV) and cerebrovascular outcomes ,several studies resulted in conflicting results regarding different statin types & dose effect on glycemic control. Atorvastatin which is the most widely used statin worldwide and rosuvastatin the most efficacious ;they have different structural characteristics that have been speculated to have influence on diabetes onset.Aim of the study : The present study aims at investigating the effect of different doses of atorvastatin and rosuvastatin on glycaemic indices and metabolic disorders on mice model of diet induced obesity. Materials and method : The animals were divided into two groups : one served as control that received normal regular chow & the other group received high fat diet for the whole 12 weeks of experiment.After eight weeks of HFD feeding ;group (2) farther subdivided into five groups(12 mice in each) ; the first group received HFD only ,the second group received single daily dose / po of 20mg /kg rosuvastatin ,the third group received single daily dose / po of 40mg /kg rosuvastatin ,the fourth group received single daily dose / po of 20mg /kg atorvastatin ,and the fifth group received single daily dose / po of 40mg /kg atorvastatin for the last four weeks of experiment.Body weight ,food intake, lipid profile ,glycaemic indices were taken at baseline ,before treatment and after treatment.At the end of experiment ,animals were sacrificed , plasma & tissue sample were collected for biochemical analysis and histological observations.Results : Results of the present study shows that high fat diet feeding resulted in obesity development and metabolic abnormality like; hyperglycemia ,hyperinsulinemia ,insulin resistance , dyslipidemia and moderate to severe hepatic steatohepetitis compared to control group. and treatment resulted in significant improvement in lipid profile ,reduction in food intake ,body weight ,also associated with improvement in insulin sensitivity , hepatic steatohepetitis and reduction in insulin secretion.twenty mg/kg dose of atorvastatin showed better influence on glycaemic indices and comparable influence on hepatic picture over fourty mg/kg does while twenty mg/kg dose of rosuvastatin resulted in deterioration of glycaemic indices and no apparent improvement in hepatic steatosis. Unlike group that received 40 mg /kg rosuvastatin which showed significant improvement in all related metabolic disorders. Conclusion : Feeding mice with high calories diet for 2 month result in induction of obesity and disturbance of metabolic parameters. Treatment with rosuvastatin or atorvastatin has good impact on bodyweight , metabolic derangements &hepatic steatosis in obese mice. Both drugs seems to improve lipid profile in dose dependent manner, however their effects on glycaemic indices has different attitude. It is seems that rosuvastatin, especially at high dose, has better impact on glycaemic indices than atorvastatin and this might attributed to the difference in their pharmacokinetic properties

التقييم الفسلجي للاعتلال العصبي الذاتي لمرضى داء السكري

اسم المؤلف: نسرين قادر كامل
اسم المشرف: محمد شريف عبد الله موسى محمود مربط
الموضوع العام: الطب
السنة: 2004
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Autouomic neuropaty
  • diabetics mellitus
  • heart rate
  • blood pressure
  • E C G
  • cardiovascular reflex
الصفحات الاولى:
المستخلص: (Diabetes Mellitus) D.M : - is the most common endocrine disease, characterized by abnormalities of glucose, protein and lipid metabolism. Diabetic neuropathy is one of the long term chronic complications, which contributes to increase the morbidity & mortality rate in diabetes. One of the earliest manifestations of diabetic autonomic neuropathy is denervation of the cardiovascular system, assessment of cardiovascular reflexes affords a satisfactory evaluation. Along duration time.A battery of bedside clinical tests was used to assess the autonomic function of the heart. This is the response of blood pressure to sustained handgrip and standing - up. The R - R interval change and Q - T interval change in the E, C G in response to standing - up, deep breathing and valsalva maneuver. Number of the patients was 40 diabetic subject and 22 age and sex matched healthy controls. Insulin dependent diabetes Mellitus (IDDM) was 25(62.50%) of cases, non insulin dependent Diabetes Mellitus (NIDDM) was 15(37.5%) of cases, autonomic neuropathy was detected in 23 patients (57.5%), Orthostatic hypertension in 19 cases (47.5 %), abnormal blood pressure response to sustained hand grip in 20 (50%), abnormal valsalva ratio in 10 (25%), abnormal heart rate response to deep breathing in 11 cases (27.2%).Among the 13 patients with cardiac diabetic autonomic neuropathy, had a Q - Tc interval of > 440 ms ( p < 0.05 ). Compared to the remaining 4 patients had normal Q - Tc interval of 399.5 ± 37.49ms.Cardiovascular tests for cardiac autonomic neuropathy showed increase prevalence with increase in the duration of Diabetes Mellitus above 15 years.This study showed that diabetics had significantly impaired cardio - autonomic reflexes compared to non diabetics. Also, other group of diabetics who have apparently normal cardio - autonomic reflexes were found to have significantly different values compared to the control group, (heart rate variations with deep breathing and valsalva maneuver had a negative correlation with age)

تاثير استخدام عقار الميتفورمين منفردا او مع عقار السيتاكلبتين على مستويات الاومنتين - 1 لدى مرضى داء السكري من النوع الثاني Effects Of Metformin Alone Or In Combination With Sitagliptin On Serum Omentin - 1 Levels In Patients With Type - 2 Diabetes Mellitus

اسم المؤلف: ميقات طالب حمادة
اسم المشرف: حيدر مطير خليل القريشي عبد الكريم يحيى السامرائي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الخلفية : داء السكري يشير الى مجموعة من امراض الايض مع ارتفاع مستوى سكر الدم. يمثل النوع الثاني من داء السكري ما نسبته 90 - 95% من جميع حالات السكري. يمثل النقص في الانسولين ومقاومة الانسولين وغيرها من الاضطرابات الهرمونية المشاكل الاساسية لمرضى السكري من ال | Background : Diabetes mellitus (DM) describes chronic metabolic disorders with hyperglycemia. Type II DM (T2DM) represents for approximately 90 - 95% of all diabetic types. A combination of insulin deficiency, insulin resistance and other hormonal irregularities are key problems with T2DM. Adipose tissue can be classified into two types : the brown and white adipose tissues. The white type is considered an important secretory organ which produces many bioactive molecules, collectively termed adipokines. Recently, a new adipokine named omentin - 1, has been identified and it was found that individuals with impairment in glucose homeostasis and newly diagnosed T2DM showed a lower serum omentin - 1 level. However, the effects of antidiabetes drugs on serum omentin - 1 level had not been studied extensively.Objective : The current study was design to measure serum omentin - 1 in T2DM as comparing with control subjects, also to study the effect of three months therapy with metformin and/or sitagliptin (when added to ongoing metformin therapy) on serum omentin - 1 levels in addition to other parameters.Method : This study was carried out on thirty healthy control subjects, and sixty three T2DM patients. The patients enrolled in the current study were divided into two groups. First group : included thirty one of newly diagnosed T2DM patients, started treatment with metformin. Second group : included thirty two patients with T2DM, already on ongoing metformin therapy and started treatment with sitagliptin. All patients received their treatment for three months duration, and blood samples were collected from them at the beginning of the study and after three months of starting treatment to measure the possible change in the studied parameters which include : fasting blood glucose (FBG), postprandial blood glucose (PBG), Glycosylated haemoglobin (HbA1c), serum level of insulin, insulin resistance (IR), serum omentin - 1 levels, lipid profile, body mass index (BMI) as well as blood pressure. Results : The results showed that baseline level of serum omentin - 1 in the newly diagnosed T2DM was significantly lower than matched control subjects. The level of omentin - 1 was significantly reduced after three months duration of treatment in sitagliptin group with no significant change in metformin group. FBG, HbA1c and PBG were decreased significantly after three months in metformin group, while in sitagliptin group, only HbA1c and PBG were decreased significantly after three months. In both groups, and after three months duration of treatment, there were no significant changes in serum level of insulin, IR, TG, VLDL - C, HDL - C, BMI, and blood pressure.Conclusion : In newly diagnosed patients with T2DM, serum omentin - 1 was reduced compared to age and BMI matched healthy subjects. Three months treatment with sitagliptin resulted in a significant reduction in omentin - 1 levels compared with baseline values. However, three months treatment with metformin had no significant effect on serum omentin - 1 level compared with pre - treatment value

تاثير استخدام عقار الكلورال هيدريت منفردا او استعماله مجتمعا مع عقار الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال Chloral Hydrate Alone Or In Combination With Diazepam As A Sedative For Auditory Brainstem Response Testing In A Pediatric

اسم المؤلف: مريم محمد حميد مصطفى
اسم المشرف: حيدر مطير خليل القريشي حيدر وهاب السرحان
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لبحث تاثير استخدام الكلورال هيدريت منفردا او استعماله مع الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال من اجل تقييم ما اذا كان اضافة الديازيبام له تاثير ايجابي او سلبي.اعتمدت الدراسة الحاليه على160 متطوعا من الاطفال ال | Background : children usually need sedation for diagnostic and therapeutic interventions. It is well known that pediatrics age groups are at higher risk for sedation - related complications than adults. Auditory brainstem response testing is one of the important diagnostic procedure that usually need sedation in order to preformed in children. Chloral hydrate is a hypnotic agent used since 1832 with low incidence of adverse events; whoever, despite the world wide use it is being abandoned due to bitter test, long time of sedation onset, vomiting and mild sedation. Rectally diazepam, on the other hand, produces higher and fast concentration in CSF with greater rate of success but probably with higher adverse events. Aim of the study : were to compare the sedative effect of chloral hydrate with chloral hydrate diazepam combination as well as their related adverse effects in children underwentg auditory brainstem response testing. Methods : in this randomized clinical study, 160 child underwent sedation for auditory brainstem response test participated. They were divided equally and randomly into 4 groups. Group A : Received 20 mg/Kg oral chloral hydrate as sedative, Group B : Received 20 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally, Group C : Received 40 mg/Kg oral chloral hydrate as sedative, and Group D : Received 40 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally. At the beginning, blood pressure, respiratory rates, peripheral oxygen saturation recorded, and then re - recorded immediately after drug administration and at (3, 5, 10, 20, …. min). Ramsay sedation scale used for assessment of the sedation level which measured every 10 min. Results : This study shown the beneficial use of chloral hydrate in combination with diazepam as sedation in ABR test (in groups D) by increased in the sedated number (p<0.05), decreased in the requirement of chloral hydrate re - dose, increased in the number of children whom completed ABR test (p<0.05) without significant differences on side effects or vital signs compared with the others three groups. 4.3. Conclusion : From this study we concluded that : • Used of oral chloral hydrate in dose (20mg/kg) alone not sufficient as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (20mg/kg) in combination with rectal diazepam (0.5 mg/kg) better than used it alone as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (40mg/kg) in combination with rectal diazepam (0.5 mg/kg) was the best sedative in paediatrics for ABR test. • Used of Chloral hydrate diazepam combination in ABR test of paediatrics increased the number of the sedated children, decreased the requirement of chloral hydrate re - dose, and increased the number of completed ABR test, with less complication

تاثيرات استخدام عقار الفيراباميل وعقار السايكلوسبورين في حالة اعتلال عضلة القلب الناتج من استخدام عقار الدوكسوروبسين : في الفئران المختبرية Effects Of Verapamil,Labetalol And Cyclosporine Use In The Condition Of Cardiotoxicity Resulted From Doxorubicin Use : Animal Model Study

اسم المؤلف: محـمد عبد العزيز محـمد
اسم المشرف: حيدر مطير خليل القريشي خالد جمعة خليل
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Doxorubicin is a member of anthracycline antibiotic that widely used in the treatment of different types of cancer such as hematological malignances, solid tumors, and different organ tumors, doxorubicin is very efficient in the treatment of cancer. But the use of doxorubicin is limited by the side effect of doxorubicin on the same organ, the most important organ that affected by doxorubicin is the heart, the toxicity of doxorubicin in the heart, the use of doxorubicin due to the cardiotoxicity that induced by doxorubicin will lead to cardiomyopathy and in the final result of these cardiotoxicity lead to congestive heart failure that occurred secondary to the cardiotoxicity may appear after long period of termination of treatment by doxorubicin.ObjectivesThe aim of the present study its investigate the possible modulation effect of drugs (verapamil, cyclosporine, labetalol) on the cardiotoxicity that induced by doxorubicin drug. Animals and methods forty Dwale - Spargue male rats where enrolled in this study, the animals divided into groups, (5) rats in each group and assigned as I,II,III,IV,V,VI,VII,VIII.Group I : received physiological saline (5ml/kg), orally, daily for ten days and served as the control.Group II : received a single dose of doxorubicin (15mg/kg), intraperitoneal and was sacrificed after 48 hours which served as doxorubicin group.Group III : received verapamil (5mg/kg), orally daily for ten days and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg), intraperitoneal were given.Group IV : received cyclosporine (0.5mg/kg), orally daily for ten days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg, intraperitoneal) was given.Group V : received cyclosporine (1mg/kg), orally daily for ten days ,and on day eight ,one hour after drug administration a single dose of doxorubicin (15mg/kg),intraperitoneal was given. Group VI : received both of verapamil (5mg/kg,orally) and cyclosporine (0.5mg/kg,orally) one hour apart, daily for ten days ,and on day eight, one hour after drug administration ,a single dose of doxorubicin (15mg/kg), intraperitoneal was given.Group VII : received labetalol (0.5mg/kg), orally daily for ten days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg, intraperitoneal) was given. Group VIII : received labetalol (1mg/kg, orally),daily for ten days ,and on day eight ,one hour after drug administration ,a single dose of doxorubicin (15mg/kg), intraperitoneal was given.Serum MDA, LDH, Troponin I, and interleukine - 17. Were measured and histopathological changes also viewed?ResultsThe results in this study showed an increase in the cardiac biomarkers in the doxorubicin group compared to the control group, the cardiac biomarkers that measured are LDH, MDA, Troponin I, interleukine - 17. Also the results showed histopathalogical changes in cardiac tissue in doxorubicin group as compared to the control group, also the results showed the pre - treatment with verapamil, cyclosporine low dose, cyclosporine high dose, combination of verapamil and cyclosporine low dose, labetalol low dose, labetalol high dose showed decreasing in the cardiac biomarkers MDA, LDH, Troponin I, interleukine - 17 to a significant amount compared to the doxorubicin group, also showed histopathlogical improvement in cardiac tissue. Conclusions Doxorubicin drug used as antineoplastic agent will produce a toxic effect on the cardiac tissue, this toxic effect will limit the use of doxorubicin, cyclosporine, labetalol and verapamil produced differential effects and protection from Doxorubicin induced cardio toxicity via amelioration of cardiac biomarkers and histopathological changes

عزل وتحديد هوية فيروس الحصبة في علاقته ببعض الجوانب المناعية من الاشخاص النازحين الملقحين في محافظة بابل Isolation And Identification Of Measles Virus In Relation To Some Immunological Aspects From The Vaccinated Displaced Individuals In Babylon Governorate

اسم المؤلف: ليث احمد عمران كيف الكيف
اسم المشرف: محمد عبد كاظم حسن السعدي يونس عبد الرضا كحيوش الخفاجي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة لتقييم مناعة المجتمع لكلا النازحين والمقيمين الملقحين بلقاح فيروس الحصبة ضد خمج الحصبة في محافظة بابل. لذا تضمنت هذه الدراسة معايرة الحالة المناعية في امصال النازحين والمقيمين محافظة بابل مع عزل وتشخيص فيروس الحصبة من الحالات المشتبه بها. ت | The study was conducted to evaluate the herd immunity for both the displaced and residents vaccinated with measles virus vaccine against measles infection in Babylon governorate. Therefore this study includes the evaluation of the immune status in sera of Babylon governorate displaced and residents with specific aspect for isolation and identification of measles virus from suspected cases. The immune response was evaluated by means of ELISA test (enzyme linked immunosorbet assay) for titration of IgM and IgG immunoglobulin level, in addition to evaluation of perforin level in the sera of 90 measles vaccinated individuals included in this study (50 displaced and 40 residents) from different areas in Babylon governorate, that were collected during the period extent from January up to April of 2016. Data about individuals were fixed according to information of formula including age, sex, geographical location, place displace of displaced and the vaccination date. Successful virus isolation from suspected cases on two types of cells culture included Vero cells line and chicken embryo fibroblast was carried. The titer of the isolated virus on Vero cell line reached (105.8 TCID50 / 0.1ml),which was higher than the titer of the virus isolated on CEF which reach (105.4 TCID50 / 0.1ml) after the third passage of the virus. The isolated virus was confirmed by indirect immunofluorescence technique.The age of subjects included in this study ranged from <1 year up to 24 years old. The results revealed that 15 (30%) have positive IgM index in sera of displaced, whereas residents sera sample shown only 6 (15%) positivity. Howover, all 90 (100%) subjects of both groups showed positive IgG index. The results of the present study showed that there were no significant difference of perforin level in sera of refugees and residents at p<0.05.Assaying of immune response against measles virus by measuring IgM immunoglobulin in sera of vaccinated displaced and resident with measles vaccine reflected a highly significant difference between two groups which reached 0.43 mIU/ml in sera of displaced in comparison with residents sera which reached 0.34 mIU/ml. The result showed also high significant differences in IgM between females and males. The females sera IgM levels of displaced and residents were higher than its level in males sera which reached 0.47 mIU/ml and 0.35 mIU/ml, respectively, in comparison with male sera level which reached 0.40 mIU/ml and 0.32 mIU/ml, respectively. According to age group, the highest IgM value was recorded in displaced and residents sera in age group 10 - 14years (0.50 mIU/ml) and 5 - 9years (0.36 mIU/ml) respec - tively. Whereas the lowest IgM serum value was detected in age group <1 year (0.34 mIU/ml) and 15 - 19years (0.31 mIU/ml) for displaced and residents subjects. According to geographical location, the highest IgM level was detected in sera of displaced from Tal Afar city (0.44 mIU/ml) followed by displaced from Ramadi (0.41 mIU/ml) and the lowest IgM value was detected in sera of displaced from Mosul city (0.33 mIU/ml). Whereas the highest IgM value in sera of residents in the subjects of Al - Mahaweel city (0.37 mIU/ml) followed by subjects of Hilla and Al - Qasem city (0.29 mIU/ml and 0.28 mIU/ml) respectively. For IgG serum immunoglobulin the results revealed that there was no difference in significant levels in both group population. But according to age groups significant difference between displaced and residents was detected at p <0.05 in which the 1 - 4 years old showed the highest IgG serum level in both group (1.98 mIU/ml and 2.18 mIU/ml) respectively. While the lowest IgG sera value was recorded in displaced age group of < 1 year old (0.60 mIU/ml) compared with residents age group of 20 - 24 years old (1.65 mIU/ml).It could be concluded that the results showed that the displaced do not have any effect on the residents of the province of Babylon for measles as a result of the good immunization by Babil Health directorate following to the Ministry of Health.

تاثير استخدام عقار الميتفورمين منفردا او استعماله مجتمعا مع عقار كلكلزايد على مستوى الاومنتين - 1 - في مرضى داء السكري من النوع الثاني Effects Of Metformin Alone Or In Combination With Gliclazide On Serum Omentin - 1 Levels In Patients With Type 2 Diabetes Mellitus

اسم المؤلف: سمر محمد غني سليمان
اسم المشرف: علي اسماعيل عبد الله محمد حيدر فاضل الربيعي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لبحث التاثير العلاجي لاستخدام عقار الميتفورمين منفردا او استعماله مجتمعا مع عقار كلكلزايد على مستوى الاومنتين - 1 - باالاضافة الى المؤشرات الحيوية الاخرى في مرضى داء السكري من النوع الثاني من اجل تقييم ما اذا كان الجمع بين العقارين ( | Background : Omentin is a newly identified adipokine, which is highly expressed in visceral adipose tissue, in which omentin - 1 is the main isoform in human circulation, associated with cardio - metabolic disturbances. So considering the impact of anti - diabetic drug on omentin - 1 levels may provide adjuvant strategy to protect diabetic patients against clinical hazards.Aim of the study : The present study aimed to investigate the influence of treatment with metformin alone or in combination with gliclazide on the level of serum omentin - 1, in addition to the other biomarkers adopted in the study in order to evaluate whether the combined therapy (metformin plus gliclazide) ameliorate or adversely effects on some cardiac protector markers of metformin among recently diagnosed patients with type 2 diabetes mellitus.Methods : A total number of 100 recently diagnosed patients with type 2 diabetes mellitus were enrolled in the present study from December 2014 until June 2015. Sixty eight patients completed the 12 weeks course of treatment; divided into two equal groups based on treatment regimen in which group1 treated with metformin and group2 treated with metformin plus gliclazide. Thirty two patients did not complete the course of the treatment for unknown reasons and considered as default. In addition to 31 healthy volunteers were randomly chosen and considered as Control Group. In which all the participants in the study underwent detection of blood pressure, pulse rate, weight, height & BMI in addition to the estimation of the levels of others biochemical analysis as glycemic indices, lipid profile & serum omentin - 1at the beginning of the study & after 12 weeks of treatment regimen.Results : The results of this study shown the beneficial amelioration of metformin on some markers that affect CVS represented as significant reduction in BMI (p<0.05), modest improvement in lipid profile with modest elevation in HDL level & lowering blood pressure, significant reduction in the levels of blood glucose & HbA1C (p<0.05), improves insulin sensitivity, reduced insulin resistance, and elevation of serum omentin - 1 level among newly diagnosed type 2 diabetic patients (group1). Furthermore, the results of current study are revealed that adding of gliclazide to metformin in treatment of type 2 diabetic patients might influence the documented beneficial effects of metformin on cardiovascular system at least by adversely changing the levels of serum omentin - 1 among group 2. Conclusions : Adding of gliclazide to metformin in treatment of patients with type 2 DM might extend the therapeutic action of metformin in regarding much better controlling of glycemic indices, insulin sensitivity and lipid profile. But, at the same time, it might attenuate some of beneficial effects of metformin on cardiovascular system at least by adversely influence on body weight and serum omentin - 1 levels.

تاثير استخدام عقار النكلوزمايد بالمقارنة مع عقار المتفورمين على وزن الجسم ومؤشرات السكر في السمنة المحدثة عند الفئران Effects Of Use Of Niclosamide Drug In Comparison With Metformin Drug On Body Weight And Glycemic Indices In High Fat Diet Induced Obese Mice

اسم المؤلف: خالد دهان صليبي
اسم المشرف: علي اسماعيل عبد الله محمد خالد جمعة خليل
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: في ستينيات القرن الماضي كان هناك نوع من العلاجات تستخدم للسيطرة على وزن الجسم او لتخفيفه , تلك المواد تعمل على تثبيط عضيات المايتوكوندريا من انتاج الطاقة وتحويل مجرى تفاعلات الاكسدة نحو انتاج الحرارة بدلا عن الطاقة وبذلك تحفز من زيادة اكسدة الشحوم ومادة ا | Background : Obesity is a state of excessive accumulation of fat tissue in the body , increasing energy expenditure is good way to manage obesity and the related complications. Mitochondrial uncouplers increase energy expenditure , they used before for weight controlling programs because these compounds uncouple mitochondria from generating ATP , moreover stimulate lipid and glucose oxidation preventing lipid accumulation in excess caloric intake conditions specially. Niclosamide an old drug introduced in 1960s as anthelmintic and had FDA approval for the treatment of most of tapeworm infections. It is well known mitochondrial uncoupler.Aim of the study : The present study aimed to investigate the influence of trial of the use of niclosamide in comparison to effect of metformin and their combination on body weight , glycemic indices and lipid profile in high fat diet induced obese mice.Materials and methods : The animals firstly divided to two groups one fed with normal regular mouse chow (30 mice) and the 2nd fed with high fat diet (60%kcal) for 2.5 months(100 mice) 10 mice from each group sacrificed at beginning of study represent baseline values and another 10 mice from each group sacrificed after 2.5 months to assess effect of high fat diet on study parameters. The group that fed with high fat diet further subdivided to 4 groups after 2.5 month of high fat diet feeding each 20 mice , 10 mice from each group sacrificed before treatment represent pretreatment values. Before treatment there are 5 groups assigned as group 1 fed normal regular mouse chow till the end of study , group 2 fed high fat diet without treatment till the end of study , group 3 fed with high fat diet till the end of study and treated with niclosamide for one month (150mg/kg) after obesity induction by high fat diet , group 4 fed with high fat diet till the end and treated by metformin (300mg/kg) for one month and finally group 5 fed with high fat diet till the end of study and treated by combination of niclosamide and metformin (150mg/kg , 300mg/kg respectively). blood samples taken from tail vein to evaluate the study parameters at baseline and after obesity induction by high fat diet (after 2.5 months) and after treatment ,then animals were sacrificed and livers were taken for histopathological observations.Results : The results of this study shown that the animals fed with high fat diet show metabolic disturbances manifested by significant increase (P < 0.05) in body weight , fasting insulin & fasting plasma glucose. Lipid profile show significant changes (P < 0.05)(cholesterol , triglycerides ,low density lipoproteins increased while high density lipoproteins decreased ) as compared to control group. High fat diet group also show impaired glucose tolerance , impaired insulin sensitivity and obvious liver structural changes manifested by sever steatosis.Treatment with niclosamide show improvement in all metabolic disturbances induced by obesity ; body Weight , fasting insulin and fasting plasma glucose reduced significantly (P < 0.05). Lipid profile parameters improved ; cholesterol , triglycerides , low density lipoproteins reduced significantly (P < 0.05) by one month treatment with niclosamide and high density lipoproteins increased significantly (P < 0.05) as compared to their baseline values before treatment, Glucose and insulin tolerance improved. It is nice to mention the influence of niclosamide in this study was comparable to metformin in all evaluated parameters.Combination of both drugs show favorable improvement in metabolic disturbances induced by obesity rather than each drug when used alone specially on liver histopathological changes.Combination of both drugs show significant reduction (P < 0.05) in body weight ,fasting plasma glucose and fasting plasma insulin. Lipid profile parameters improved significantly (P < 0.05) , glucose and insulin tolerance improved.Liver histopathological changes ameliorated to higher extent and become the closet to normal liver tissue morphology.Conclusions : The result suggest niclosamide have good antidiabetic action and can ameliorate the metabolic changes induced by obesity significantly. Its action is comparable to that of well known antidiabetic drug metformin. Niclosamide has favorable effect on body weight and can reduce body weight. Its combination with metformin show better improvement in metabolic disturbances induced by obesity and it has very good hepatoprotective effect against liver histopathological changes induced by high fat diet.

دراسة مستوى الهيبسيدين ومستقبلات الترانسفرين في عينات من المرضى العراقيين المصابين بحالات فقر دم نقص الحديد واضطرابات زيادة الحديد في الدم Study Of Hepcidin Level And Transferrin Level In Samples Of Iraqi Patients With Iron Overload And Iron Deficiency Disorders

اسم المؤلف: داليا نايف جاسم
اسم المشرف: علاء الدين مظفر زبير القاسم
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الامراض - الدم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الباثولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The circulating peptide hepcidin is secreted mainly by the liver as an 84 - amino acid precursor that is subsequently processed and secreted as a 25 - amino acid peptide form. It is considered the "master regulator" of iron metabolism.Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin - iron complex through receptor - mediated endocytosis. This study addresses the physiological role of hepcidin in vivo and investigates the role of hepcidin as an erythroid regulator, contributing to the modulation of iron absorption by the intestine and iron release by the macrophages in the situation of anemia with normal or increased iron stores. Measuring the transferrin receptor level and it's relation to hepcidin is another part of the data involved in this study.Methods : This study included 64 Iraqi patients, 34 of them have iron deficiency anemia and the other 30 are iron overload patients. They attended the National Center of Hematology and Thalassemia center in Al - Karama Teaching Hospital during the period from October 2014 until April 2015 together with 30 healthy controls. Information regarding age, sex and clinical presentation were recorded. ELISA technique used to measure hepcidin and transferrin receptors level in patients and healthy control groups.Results : ? Mean serum hepcidin level in iron deficiency anemia patients was (205.3ng/ml) while in iron overload patients was (6.7ng/ml).? Mean serum level of transferrin receptors in iron deficiency anemia was (11006.3ng/ml) and in iron overload was (604.5ng/ml).Conclusion : ? The mean level of serum hepcidin in thirty iron deficiency anemia patients is high. Its elevation represented an acute phase response. While in thirty patients with iron overload, hepcidin mean level was low mainly due to stress erythropoiesis.? The current study result addresses the usefulness of soluble transferrin receptor for assessing high iron status in population and how soluble transferrin receptor is useful in the evaluation of anemic patients.

تقييم نظام المعلومات الصحي في العراق Assessment Of The National Health Information System In Iraq

اسم المؤلف: ثائر عيسى مراد
اسم المشرف: مازن غازي جاسم الربيعي امجد داود نيازي
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعتبر الاحصائيات الصحية الرصينة ضرورة لاتخاذ القرارات السليمة في كل مستويات النظام الصحي. ولكن في الحقيقة ان نظم المعلومات الصحية في معظم البلدان تعتبر غير كافية لتوفير المعلومات اللا زمة لدعم الادارة الصحية ولهذا فان معظم النظم الحالية تعتبر كعائق اداري | Sound health statistics are essential for health decision - making at all levels of the health system. Unfortunately, health information systems in most countries are inadequate in providing the needed management support and the current systems are therefore widely seen as management obstacles rather than as tools, the current study is an attempt to assess the health information system in Iraq with recognizing the strengths, weaknesses and gaps in addition to assessment of the structure and performance of this system; it also attempts to assess the behavioral, technical and organizational determinants affecting the health information system performance. A cross - sectional study was conducted for the assessment process and the levels of the assessment included the ministry of health (national level), the health directorates (provincial level), the districts related to the health directorates reaching to the health centers level, as well as the hospitals related to the health directorates, in addition to the ministry of planning and the ministry of interior. In addition to ministry of health (central level) a total of six governorates were selected by simple random sampling including the capital Baghdad with a seven districts were selected from those governorates also by simple random sampling and a total of twenty six health centers were selected from those districts, as well a total of seven hospitals were included in the study from all governorate and they were selected according to convenience. The interview has been done by using the health metrics network assessment tool version 4, in addition to a complementary assessment tools which are the PRISM package tools that were used at the district and primary health center levels. Based on the data collected and according to the health metric network assessment tool findings the overall health information system has laid in the adequate state (65.96%) with most of its comprising components function poorly. Data dissemination and use and data management categories were the weakest with a score of 50% and 53.3% respectively, while for the resources category it was found to be adequate 63.3%, and for that of HIS indicators, data sources and information product categories they were 73.3%, 66% and 69.6% respectively. For that of the PRISM tools and the findings obtained by them from the collected data the results revealed that a low data quality in term of accuracy with 29.03% at the facility level and 55.35% at the district level, while the completeness rate was excellent with a score 96.38% at the facility level and 98.23% at the district level, for that of the timeliness it was 70.43% timeliness at the district level. The information use for a given feedback at the facility was 50% and at the district was 82.12% and for observed meeting records it was 50% for the facility and 41.6% for the district level. For that of the functionality a 34.61and 67.30% of the facilities reported having a reminder mechanism for data completeness process and meeting a deadline for submitting monthly reports respectively, Data analysis was better at the district 85.71% than at the facility 81.7%, Data display were present in all of the facilities and districts. For the technical determinant the results showed 57%, 85.7%, 71.4% and 100% of the district respondents felt that the form is complex and difficult to follow, data software is a user - friendly, information technology is easy to manage and a comprehensive picture of the health system performance is captured by the system respectively,85.7% believed that the information system collecting information from some vertical programs and one district reported of no collection at all, in addition to that 100% reported the absence of a software that integrates data from different information systems and the available information technology doesn&#39;t provide full access procedure to district and senior managers. Regarding the behavioral determinants the results revealed that overall mean confidence for the information system tasks is 69.41% while for that of the task competence the overall mean competence level is 37.1%. Knowledge of checking data quality, knowledge of health information system rationale and problem solving showed results of 35.32% 37.68% and 2.98% respectively, and that of motivation level was 43.4%. Organizational determinants results revealed that the management functions at facility and district levels were almost absent, while for the perceived promotion of a culture of information it showed a total score of 63.96% and rewarding for a good performance was 56.83%. The activities for promotion of a culture of information are a 25% at the facility level and 28.75% at the district level. And that of supervision quality at the facility were (72.80%). Availability of resources revealed that 100% of the facilities have two or more computers and calculators respectively while only 57.7% have an internet access. Access to the electricity and water supply is very high, No facility reported of running out in registers in the last 12 months. Finally, the current study shows the importance for the need of further attention to be drawn to HIS, in addition to that, increasing the awareness and well coordinated efforts that need to be done to overcome weaknesses and to provide a well functioning HIS enabling for evidence based decision making and action provision in the health system.

تاثيرات السيتاكولين ,الجنسنك واستخدامهما معا على الذاكرة العملية والاداء الحركي النفسي Effects Of Citicoline, Ginseng, And Their Combination On Psychomotor Performance And Working Memory

اسم المؤلف: تيسير لطيف علي
اسم المشرف: حيدر القريشي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اساس الدراسة : اجريت الدراسة الحالية لتقييم التاثير العلاجي لعقار السيتاكولين والجنسنك واستخدامهما معا على الذاكرة القصيرة المدى والاداء الحسي الحركي, وذلك من خلال دراسة الاثار المركزية والطرفية للعقارين على مقاييس الاداء الحسي الحركي , الذاكرة العمليه , | Citicoline is one of components that present in the human brain, which act to protect the neurons and enhance memory and other cognitive functions due to its choline in their structure which play an important role in the biological membrane biosynthesis. On other hand Ginseng is an herbal plant is known for its therapeutic medical importance, it's used for different purposes in medical fields, that is effective against many diseases, act as a tonic and provide energy with significant reduction in mental and physical fatigue.Aims of the study To evaluate the central effects of Panax Ginseng and/or citicoline on normal healthy volunteers.Material and Method The subjects are randomly divided into four groups for assessment of central effects of Panax Ginseng and /or citicoline compared with placebo. The evaluation of the central effects was done by using the Leeds psychomotor battery tester for evaluating the psychomotor performance, workshop test was used to evaluate working memory function.The enrolled volunteers were randomly divided into the following groups : First group regarded as control group that treated with 500 mg/day of starch capsule as a single dose, second group, received Panax Ginseng capsule 500 mg /day, a third group received citicoline capsule 500 mg/day and the fourth group received Panax Ginseng capsule 500 mg/day plus citicoline capsule 500 mg/day as a single dose. All participants are followed for two consecutive weeks from starting treatments.ResultsIn the present study the placebo didn't have any central effect and MDA serum levels were not significantly change. Panax Ginseng has statistically significant effect on the most parameters of the psychomotor performance, working memory performance, as well as reduction of MDA serum levels. On the other hand, citicoline has statistically a significant effects on most parameters of the psychomotor and working memory function with statistically significant reduction of MDA serum levels.The combination of Panax Ginseng and citicoline have a highly statistically significant effect on all psychomotor performance, working memory performance and statistically significant reduction in the oxidative stress marker (MDA). ConclusionResults of the present study showed that combined effects of citicoline plus Panax Ginseng on central function produced more statistically significant effects on psychomotor performances, CFFF and working memory function than either Panax Ginseng or citicoline when they used alone, in addition to the combined effects of citicoline plus Panax Ginseng have a more significant effect on the oxidative stress,during mental stress.

تقييم وحدات الرعاية المركزة لحديثي الولادة في ردهات الولادة لمستشفيات بغداد Evaluation Of Neonatal Intensive Care Units At Maternity Wards In Baghdad Hospitals

اسم المؤلف: بشرى احمد عبد اللطيف
اسم المشرف: جمال محمود الخضيري
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تتباين انظمة الرعاية لحديثي الولادة المطبقة ولكنها كلها تعتمد على وحدات الخدج الموجودة في مختلف بلدان العالم النامية والمتقدمة.انجزت هذه الدراسة المقطعية التقويمية في وحدات حديثي الولادة لردهات الولادة في مستشفيات بغداد (الكرخ والرصافة) مستثنين وحدات ال | Neonatal health care is provided via a variety of neonatal care units that are available globally both in different developing and developed countries.A cross - sectional evaluation study was conducted in all accessible fifteen neonatal intensive care units in Baghdad (Kharkh and Rosafa) maternity wards, excluding paediatric hospitals, during the period from November 2013 till the end of March 2014.The study aims : 1. Health care evaluation in neonatal intensive care units of maternity wards in Baghdad hospitals in terms of input (human and non - human resources) and outcome.2. Identifying causes of admissions and causes of deaths occurring in neonatal intensive care units The study consisted of two parts : A structure evaluation is using a check list to assess availability of human and non - human resources, covering infrastructure, manpower, equipment, and supplies; and an outcome evaluation study using hospital registration records review for causes of admission and causes of death in neonatal intensive care units during the year 2013.It was found that the mean number of specialist doctors in neonatal intensive care units was 2.1 and with standard deviation ±1.3, and college nurse was 2.2, with standard deviation of ±4.004, pharmacist was 0.4 with standard deviation of± 0.516 and for supplementary staff 1.5 with standard deviation of± 0.516.More than half 54% of nurses had no training in neonatal care.Concerning the availability of general equipment it was adequate except for computers 40%.Air conditioning, lighting and windows in addition to safe water supply was good 100% but ventilation was poor 67%, hand washing area was not always present 60% and free elbow operated water tubes were available in 6.7%. Availability of neonatal intensive care units special area was adequate for storage area 85.7% gowning area78.6%, while all the remaining areas were poorly available (resting room, examining room, mother room, boiling and autoclave room, area for mixing intravenous fluid and medication).Neonatal intensive care units were narrow and area/incubator ranging from 2.28m2 to 4.36m2/ incubator. Number of incubators was 246 with patient/ incubator ratio 53.6 : 1 and 27% of Neonatal intensive care units had no regular maintenance for incubators. Large Neonatal intensive care units >25 incubators were overcrowded, having below standards area/incubator, incubators covers only two third of neonatal care. Still up to one third of Neonatal intensive care units are getting their oxygen supply by cylinders, not pipes. Most equipment for individual use were poorly available. Most of Neonatal intensive care units emergency (cupboard) drugs and supplies were sufficiently available round the clock. Total admissions to Neonatal intensive care units were 13195 neonates. Male neonate's admissions 60% were higher than females 40%. Main causes of admission were Respiratory distress syndrome 43%, prematurity and low birth weight 19.4%, and Transient tachypnea 17.4%; birth asphyxia 4%, and hypoglycemia 3.8%, Congenital anomalies 3.7%, Neonatal jaundice 3%, while meconium aspiration and septicemia were the lowest1%. From all these admissions 74% were discharged well, (6%) were referred, while those discharged against medical advice were (4%) and the rest (16%) died. The main causes of death in Neonatal intensive care units were Respiratory distress syndrome 34%, prematurity and low birth weight 31% congenital anomalies 12%, birth asphyxia 8%, septicemia 4%, meconium aspiration 1% and 10% due to other unclassified causes. From this evaluation study, it can be concluded that there were Neonatal intensive care units with under staffing, undertraining and poor designing. Respiratory distress syndrome and prematurity were the main neonatal health problems.

تقييم استخدام الروزوفاستاتين والتلميسرتان في حالة تسمم عضلة القلب الحاد المحدث من استخدام الدوكسوروبيسيبن في الجرذان المختبرية Evaluation The Usage Of Rosuvastatin And Telmisartan In Doxorubicin Induced Acute Cardiotoxicity In Rats

اسم المؤلف: ايهاب اياد احمد
اسم المشرف: علي اسماعيل عبد الله محمد خالد جمعة خليل
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لتقييم التاثيرالعلاجي لاستخدام الروزوفاستاتين والتلمسارتان في التقليل من سمية القلب المحدثة من عقار الدوكسوروبسين في الجرذان المختبريةباستخدام الطرق الكيميائية الحيوية والنسيجية ومقارنة تاثير الاستخدام المزدوج بفعالية استخدام كل م | Background : Doxorubicin, an anthracycline antibiotic is a powerful antineoplastic drug, but its therapeutic usefulness is limited by its cardiotoxicity. Aim of the study : The present study investigated the influence of pretreatment with rosuvastatin and telmisartan alone or in combination in different doses on doxorubicin induced acute cardiotoxicity in rats using biochemical and histological approaches. Materials and methods : The animals were divided into eight groups of 5 animals each. The first group received no drug(s) po but a single dose of distilled water (7.5 ml/kg, ip) on day eight, which serves as the control group. The second group received no drug(s) po but a single dose of doxorubicin (15 mg/kg, ip) on day eight, and serves as doxorubicin only received group. The third and sixth group received rosuvastatin (2 , 10) mg/kg/day respectively for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given. The fourth and seventh group received telmisartan (2 , 4) mg/kg/day respectively for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given. The fifth and eighth group received both drugs, where the fifth group received both of rosuvastatin (2 mg/kg, po) and telmisartan (2 mg/kg, po), 1 hour apart, daily for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given. While the eighth group received both of rosuvastatin (10 mg/kg, po) and telmisartan (4 mg/kg, po), 1 hour apart, daily for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given.At day ten of the study, blood samples were taken for biochemical analysis, then animals were sacrificed and hearts were taken for histopathological observations. Results : Rats treated with doxorubicin showed cardiotoxicity as evidenced by significant elevation of serum cardiac troponin (CTn - I) level, lactate dehydrogenase (LDH) activity, serum malondialdehyde (MDA) level, and interluekine 17 (IL - 17) level associated with important histopathological alterations while pre - treatment with rosuvastatin and telmisartan elicited a significant decrease in the activities of all markers measured in comparison with doxorubicin treated group with pronounced resolution of Dox induced cardiac histological changes to a milder picture.Conclusion : These results suggest pretreatment with rosuvastatin and telmisartan alone or in combination provide a significant protective effect against acute - doxorubicin induced cardiotoxicity in rats represented by biochemical markers and histological approaches.

العلاقة بين تجارب الطفولة السيئة والمطاوعة على الصحة بعد البلوغ في بغداد The Relationship Of Adverse Childhood Experiences And Resilience To Adult's Health In Baghdad City

اسم المؤلف: اميل فاروق الشاوي
اسم المشرف: رياض خضير لفتة صالح الحسناوي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: طب المجتمع
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تجارب الطفولة السيئة تشير الى اكثر مصادر الاجهاد شيوعا وشدة التي يعاني منها الاطفال في حياتهم المبكرة. من هذه الخبرات الاساءة، الاهمال، العنف بين الابوين او مقدمي الرعاية والعنف المجتمعي. وتبين ان الاجهاد الطويل في الطفولة له اثار طيلة الحياة على صحة | Adverse Childhood Experiences refer to some of the most intensive and frequently occurring sources of stress that children may suffer early in life. Such experiences include multiple types of abuse; neglect; violence between parents or caregivers and community violence exposure. It has been shown that prolonged stress in childhood has life - long consequences for a person's health and well - being; it may lead to serious problems such as alcoholism, depression, eating disorders, heart diseases, cancer, and other chronic diseases. Resilience is the ability to manage crises, difficult situations and developmental tasks. Research on resilience has identified several factors that strengthen the power and resources of children as well as promote their abilities to cope successfully with crises and internal and external problems. This cross - sectional study was conducted to estimate the effect of adverse childhood experiences and resilient factors on adults’ heath. It was done during the period from January 2013 through January 2014. The study sample was drawn from Baghdad City. Multistage sampling technique was used to choose 13 primary health care centers and eight colleges from three universities in Baghdad; the questionnaire was filled through a direct interview with the participants. In addition to that, teachers of seven primary schools and two secondary schools were chosen by a convenient method. A total of 1040 subjects were surveyed and 1000 responded. Their age ranged between 18 to 59 years (32.08±11.169). Females constituted a higher proportion (58.3%) of the study sample, 60% of this sample had university/diploma as the highest level of education. The results showed (during childhood) that seeing or hearing a parent or household member in home being yelled at, screamed at, sworn at, insulted or humiliated was reported in 469 (46.9%). A parent, guardian or other household member yelled, screamed or swear at, insulted or humiliated them was registered in 387 (38.7%). A parent, guardian or other household member spanked, slapped, kicked, punched the subjects was seen in 335 (33.5%). father's death (when the subject's age was 15 years or less) was reported in 104 (10.4%) of the participants, and 74.8 % of the subjects like to be the kind of people their parents were. The multiple linear regression models demonstrated that being in the fourth quartile (highest quartile) of household dysfunction - abuse score is expected to significantly increase depression symptoms score by a mean of (10.4) compared to subjects in the lowest (first quartile) of household dysfunction - abuse score, being in the fourth quartile of family bonding score is expected to significantly decrease depression symptoms score by a mean of ( - 22.5) compared to subjects in the first quartile, the same is correct for self - esteem score which increases by a mean of (21.484) for the fourth quartile of family bonding score compared to subjects with lowest (first quartile) after adjusting other explanatory variables. Logistic regression model showed that being in a higher level of family bonding (fourth quartile) is expected to reduce the risk of having chronic physical diseases by almost the half (odds ratio =0.57) and being exposed to a high level of household dysfunction and abuse (fourth quartile) is expected to increase the risk of having chronic physical diseases by 81%. A positive history of suicidal attempts showed a strong positive association with mean score of household dysfunction and abuse. Family bonding during childhood appears to be the most important resilient factor that protects adults against sedative or narcotic usage, mental disorders, suicide attempts, and chronic physical diseases during adulthood. Higher levels of exposure to adverse childhood experiences have a positive association with substances usage, suicide attempts, symptoms of mental disorders and chronic physical diseases in adulthood.

التغيرات الكيما حيوية في مصل الدم لتراكيز الهيبسيدين والانترلوكين - 6 نسبة لحالة الحديد قبل وبعد العلاج الكيميائي عند المرضى البالغين المصابين بسرطان الدم النيقاني الحاد Biochemical Changes In Hepcidin And IL - 6 Concentrations Relative To Iron Status In Patients With Acute Myeloid Leukemia Before And After Treatment

اسم المؤلف: هبة عمار محمد
اسم المشرف: ختام عبد الوهاب علي علاء فاضل علوان
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: هدف الدراسة : لتعيين العلاقة بين هرمون الهبيسيدين (hepcidin) (الهرمون المنظم لتوازن الحديد في الجسم والانترلوكين - 6 ( (interlukin - 6و علاقتها ببعض المتغيرات الكيميائية الحياتية عند المرضى المصابين بابيضاض الدم النيقاني الحاد ((AML قبل وبعد اكمال الجرعة الك | Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissues characterized by the accumulation of abnormal blast cells, especially in bone marrow, and impaired production of normal blood cells. The statistics show that this disease in men is more prevalent than women and this type of leukemia is increasing with age. Objectives : To assess biochemical changes related to iron status in acute myeloid leukemia pre and post course of chemotherapy and evaluate a relationship between serum hepcidin and IL - 6 in patients with acute myeloid leukemia pre and post chemotherapy and compare their levels to controls and their contribution on the pathogenesis of AML.Patients, Materials and Methods : The present study conducted at the National Center of Hematology and Baghdad Teaching Hospital in the Medical City from February 2014 to June 2014.The study included Fifty - eight (58) patients (30 male and 28 female) diagnosed with acute myeloid leukemia the age of patients range (15 - 65 years). Forty three (43)patients continued the study (24 male and 19 female) divided into two groups : Group (1) Patients with AML before starting chemotherapy. Group (2) the patients after 4 weeks of chemotherapy. Patient's treatment was done according to international protocol used in acute myeloid leukemia and called (3+7) where Doxorubicin was given from the first day to third day and Cyatrabine (Ara - C) was given from the first day to seventh day.Evaluationwas done on day (28) from starting chemotherapy to assess response of patients through bone marrow aspiration.All patients were subjected to complete history and physical examination. Diagnosis of AML patients was established by complete blood count and blood film, bone morrow aspiration and biopsy, hepcidin, interlukine - 6, C - reactive protein, ferritin, iron, total iron binding capacity, alkaline phosphstase, direct bilirubin were done for all patients.Forty - three (43) healthy subjects (24 male and 19 female) were enrolled in the study mainly from medical staff and their families. They were age and sex matched to patients group and considered as controls as ( Group 3).Results : • Serum hipcidin levels were significantly higher in(AML)patients (Group 2) compared to newly diagnosed(Group 1) and to healthy subjects ( P<0.0001).• Serum (IL - 6) levels were higher but not significant in(Group 1) compared to (Group 2) and significantly with healthy controls(P<0.214 and P<0.0001 respectively).• A significant increase in mean of serum ferritin levels were observed in (Group 2) compared to newly diagnosed patients (Group 1)(P<0.002) and the levels were significantly higher in newly diagnosed group compared to healthy controls (P<0.015).• Patients with (AML) during remission show significant decrease in levels of iron compared to newly diagnosed group(P<0.0001),while levels in healthy controls was higher values than both (Group 2) and (Group 1) (P<0.0001).• Total iron binding capacity (TIBC ) levels showed a significant decrease in (Group 2) after treatment compared to (Group 1) before treatment(P<0.0001) but the levels were significantly higher in healthy controls compared to (Group 1) and (Group 2) (P<0.0001).• Mean serum ALP levels showed highly increase in (Group 2) patients when compared to patients before treatment (Group 1)( P<0.0001), but the difference is not significantly higher between the newly diagnosis and controls (P<0.687).• A significant increase in mean serum direct bilirubin levels were observed in (Group 2) patients when compared to (Group 1) and healthy controls(P<0.0001).• Regarded to CRP levels in AML patients before and after treatment, the CRP levels increased in AML patients after treatment than newly diagnosed AML patients.Conclusions : Hepcidin and Interlukin - 6 may be used asprognostic for acute myeloid leukemia and also can play an important role in pathogenesis of AML.

دور هرمونات الاديبونكتيندور واللبتين والسايتوكينات لدى بعض المرضى المصابين بعجز القلب المزمن Role Of Adiponectin Leptin&Other Cytokines In Some Chronic Heart Failure Patients

اسم المؤلف: نور نصير نافع
اسم المشرف: عدنان فاضل النجار صباح موسى فاضل
الموضوع العام: الطب
السنة: 2010
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Adiponectin
  • leptin
  • cytokine
  • Chronic Heart Failure
الصفحات الاولى:
المستخلص: عجز لقلب المزمن : حالة تقويضية معقدة متمثلة بمرحلة تشخيصية متقدمة مدمرة ونهائية. ان عملية انتقال المرض من مستقر الى دنف القلب(اعتلال عام مع هزال) ليست مفهومة جيدا, وهناك عدد من العمليات المختلفة للحفاظ من عملية الهدر، وهي في معظمها حيث وجدت لتكون في وقت م | Chronic Heart Failure(CHF)is a complex catabolic state that carries a devastating prognosis. The transmission from stable disease to cardiac cachexia is not well understood. A number of different mechanism maintain the wasting process, most of which were found to be activated early in the development of CHF.Many of these pathways are initially activated to protect heart from damage and to compensate for impaired myocardial function. Mediators that have been implicated in this process include pro - inflammatory cytokines like interleukin 1 and 6, tumour necrosis factor - ? and the acute phase protein (C.R - P)these cytokines are activated during the course of CHF and maintaining the wasting process. Little is known about the mechanism leading to cardiac cachexia (C.C).Adiponectin and leptin are a protein hormones derived from adipocytes and they are important regulator of energy metabolism and body weight. Previous studies of CHF and C.C , had great differences between cachectic and non - cachectic patients.OBJECTIVETo study the relationship between Adiponectin, leptin & cytokines in cachectic &non cachectic HF patients & compared the results with coronary artery disease( CAD) patients with preserved left ventricular systolic function( LVSF) &healthy control to elucidate their roles in pathobiochemistary of cachexia, & to study the prognostic power of adiponectin in CHF, also to identify & confirm the role of proinflammatory cytokine(IL - 6& TNF - ?)& systemic inflammation marker (C - R.P)in the progression of CHF to cardiac cachexia.SUBJECTS &METHODE Studies were performed in Cardiology Clinics in Ibn Al - Betar hospital for cardiac surgery. Eighty eight subjects were divided into four groups each contain 22 subjects are enrolled in this study : 1st group : patient with HF(reduce LVSF)with cachexia include 5 females &17 males with age range from 47 - 76 years;2nd group : patients with HF(reduce LVSF)but without cachexia include 6 females& 16 males with age range from 34 - 70 years;3rd group : patients with CAD (preserved LVSF)include 11 males &11 females with age range from35 - 80 years & 4th group : consisted of healthy controls include 11male s& 11 females with age range from 36 - 65 years. The hormonal assay was done by ELISA.RESULTSPatients with CHF with cachexia had significantly higher concentrations of adiponectin than all other groups(p=0.004) ,that are associated with significant decrease in serum level of leptin(p=0.002), significant increase in serum level of IL - 6 when compared to other groups (p=0.0001)& significant increase in number of C - R.P positive compared only to healthy control(p=0.007),but serum level of TNF - ? is significantly decrease when compared to both CAD(p=0.023) &healthy control (p=0.0001)although it was non - significant decrease when comper to patient with CHF without cachexia.In the patient with CHF without cachexia, non - significant increase in serum level of adiponectin (when compared to patient with CAD with preserved LVSF& non - significant decrease compare to healthy control), while serum level of leptin was non - significantly decrease (when compared to patient with CAD with preserved LVSF & non - significant increase when compared to healthy control) associated with non - significant decrease in serum level of TNF - ? in comparison to CAD with preserved LVSF but significant decrease compared healthy control(p=0.011)while serum level of IL - 6 significantly increase in comparison to both CAD with preserved LVSF(p=0.01) &healthy control(p=0.008).In CAD with preserved LVSF non - significant decrease in serum level of adiponectin,while non - significant increase in serum level of both leptin , IL - 6 & TNF - ? when compared to healthy control. In this study there is strong significant positive correlation between adiponectin & TNF - ? in patients with CAD with preserved LVSF(r=0.615,p=0.002); while adiponectin was positively correlated with E.F% in patients with CAD with preserved LVSF(r=0.448,p=0.037).Finally there is significant positive correlation between TNF - ? & IL - 6 in patients with CHF with cachexia(r=0.466,p=0.029).CONCLUSIONCachexia, is a catabolic state of CHF associated with increase in serum adiponectin concentration, this may be consider as preservation of physical response to the changes in body fat but might also suggest that adiponectin plays a role in pathogenesis of cachexia, while cachexia associated with HF is not caused by enhance leptin release but, by increased level of adiponectin which is powerful predictor of cardiac cachexia.Cardiovascular Disease(CVD) is associated with elevated marker of systemic inflammation)C - R.P(that plays important role in disease progression& increase level of proinflamnmatory cytokine)IL - 6(has been reported as important pathogenic factor contributed to cardiac injury during CHF& progression to cardiac cachexia, although ,the level of TNF - ? is lower & has no relation to the degree of cachexia

تقييم نسبة الاديبونيكتين والانترلوكين - 6 واضداد البروتين الستروليني في مصل الدم وتركيب الجسم مع الكثافة الكتلوية للعظم لدى المرضى المصابين بالفصال العظمي العقدي Evaluation Of Serum Adiponectin , Interleukin - 6 , Anti - Cyclic Citrulinated Peptide And Body Mass Index With Bone Mineral Density In Nodal Osteoarthritis Patients

اسم المؤلف: مصطفى سالم خلف
اسم المشرف: عدنان فاضل النجار عباس طعمة جودة الخزاعي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الفصا العظمي العقدي هو واحد من انواع التهاب المفاصل الموضعي. هو مرض المفصل التنكسي او الانحلالي, ويشمل الغضروف المفصلي والعظم تحت الغضروف, وهو يعتبر نوع من انواع امراض المناعة الذاتية. السبب الرئيسي للفصال العظمي العقدي غير معروف لكن هناك اسباب متنوعة مثل | Nodal osteoarthritis (NOA) is one type of the localised osteoarthritis that mostly occurs with postmenopausal women. It is degenerative joint disease, including articular cartilage and subchondral bone, it consider type of autoimmune diseases. The main cause of NOA is unknown but there are variety of causes like hereditary and metabolic, may initiate processes leading to loss of cartilage. The cartilage loss process usually lead to induce the immune system to release many of immune factors like cytokines , these factors lead to generation of immune response and inflammation in the joint. The NOA mostly occurs with postmenopausal women. It affects the smaller joint. Over several years, firm knobbly swellings form on the finger joints. These are caused by osteophytes so lead to bony enlargement and are known as Heberden's nodes when they are at the end joints of fingers (distal interphalangeal joints) or Bouchard's nodes when they are at the mid - finger joints (proximal interphalangeal joints). Once the nodes are fully formed, and not necessarily painful, they do limit the movement of the fingers significantly. NOA leads to the formation of bunions, rendering them red or swollen. Some people notice these physical changes before they experience any pain, but in advance cases, many of Symptoms may include like joint pain, stiffness and sometimes an effusion. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax.Many studies have been done about inflammatory and biochemical markers in NOA and they found conflicting results. Objective1 - To evaluate serum adiponectin , interleukin - 6 (IL - 6) , anti cyclic citrullinated peptide (ACCP) and bone mineral density (BMD) in NOA.2 - To asses the CRP , RF and ESR in NOA.3 - To asses effect of age , gender , effect of BMI , smoking habit and duration of disease in NOA.Material and Method This study performed during the period from November 2013 to February 2014. These subjects were selected from patients attending the Rheumatology & Rehabilitation Consultation Unit at Al - Yarmouk Teaching Hospital. Patients and controls with hypertension, diabetes mellitus, malignancy, chronic disease of kidney, liver and any patients taken drugs that might effect the results have been excluded from the study.The laboratory tests were done in Al - Yarmouk teaching hospital laboratories and the laboratory research unit in collage of medicine / department of medical biochemistry. Subjects80 subjects (60 patients & 20 healthy controls) were enrolled in this study : A. First group : Patients with Nodal Osteoarthritis (NOA), No. = 60 (female =49 & male =11), rang of age (40 - 88) years.B. Second group : Healthy control group who had no history or clinical evidence of NOA or any other chronic disease like hypertension, DM and other chronic disease that might effect on the study data, No. 20 (female = 15 & male =5 ), rang of age (48 - 82) years.The patients were diagnosed as NOA according to the 2013 American College of Rheumatology (ACR) criteria, also the patients were diagnosed as normal, osteopenia and osteoporosis according to the 2013 American College of Rheumatology (ACR) criteria by measured of BMD (T - score) Normal : T - score (more than or equal - 1), Osteopenia : T - score ( - 1.1 - - 2.5) and Osteoporosis : T - score (less than - 2.5). The patients BMI were measured and determined as Normal (18 - 24.9 kg/m2), Over weight (24.9 - 29.9 Kg/m2), Obese grade - I (29.9 - 34.9 kg/m2) and Obese grade - II (more than 34.9 kg/m2) according to WHO 2012.MethodsELISA technique was used for the determination of serum adiponectin, IL - 6 and ACCP. Measurement of serum uric acid was done by spectrophotometric instrument. qualitative serological tests were used for determination of the CRP and RF also ESR determination were done in hospital laboratory. The BMI was determined by WHO equation's (2012) (weight/ (length) 2), also the BMD was determined by DXA scan according to ACR limits.Results obtained were subjected to statistical analysis by using SPSS and Excel program.ResultsLevels of serum adiponectin, IL - 6, CRP, ESR and BMI were significantly increased in NOA patients most than healthy controls, also the BMD (T - score) significantly decreased in NOA patients than healthy controls. But the age, gender, serum ACCP and uric acid were not significantly changed in NOA patients compared with healthy controls. Study of age, gende , BMI and duration of disease, found that they did not effect any parameters studied in NOA patients, only serum ACCP level was found to be significantly increased in females than males. Serum adiponectin level and CRP were significantly increased more in osteoporosis than osteopenia and normal. CRP was significantly increased in smoker than non smoker NOA patients.This study showed negative correlation between serum adiponectin and BMD, positive correlation between serum adiponectin and ESR, serum adiponctin and IL - 6 and IL - 6 and ESR in NOA patients. This study illustrated change in the status of the inflammatory markers like adiponectin, IL - 6 and other parameters in NOA disease. It illustrated effect of some of the factors like age, gender, BMI, BMD, smoking habit and duration of disease on development of NOA disease and on the status of the parameters studied. Also this study illustrated some correlation between the parameters in NOA patients.

المرضى المصابين بالمتلازمة الشريانية الحاد Vaspin and Omentin - 1 : تقييم مستويات Evaluation Of Serum Vaspin And Omentin - 1 Levels In Patients With Acute Coronary Syndrome

اسم المؤلف: مشتاق عبد هنيدي الطائي
اسم المشرف: ولاء احمد الجدة عباس ناجي الشريفي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Acute coronary syndrome (ACS) is an insufficient supply of the myocardium with oxygenated blood in which atherosclerosis is an essential cause of myocardial ischemia. Adipokine biomarkers plays an essential role in the atherosclerosis and hence coronary artery disease. Serum Vaspin, Omentin - 1 and troponin I Fast are the biomarkers that believed to be independently associated with acute coronary syndrome.Objective : The study was carried out to evaluate : serum Vaspin,Omentin - 1 and Troponin I Fast in patients with acute coronary syndrome [ST - Elevation Myocardial Infarction(STEMI), Non - ST - segment Elevation Myocardial Infarction (NSTEMI),and Unstable Angina pectoris (UA)], that may help in guiding the diagnosis and treatment.Subjects, Materials and Methods : The study include a total (100) individuals; (75) patients with acute coronary syndrome (ACS) and (25) healthy control.A total number of 75 patients with acute coronary syndrome (ACS) (50 male ,25 female ) as : 25 patients with STEMI (22 male and 3 female) 25 patients NSTEMI(16 male and 9 female ) and 25 patients with unstable angina UA(12 male and13 female)were enrolled in this study all taken from Coronary Care Unit (CCU)at AL - Yarmouk Teaching Hospital.Each patient was clinically examined by the consultant cardiologist and the diagnosis was achieved by electrocardiograph (ECG), and cardiac enzyme levels.Venous blood sample (ten milliliters) was drawn from each patient and control after (10 - 12) hours overnight fasting, using a 10 ml disposable syringe between 9.00 and 11.00 A.M.The sample was divided into two portions one for testing Hb concentration and the other part was centrifuged to obtain serum, to be used for measuring the following variables : serum vaspin, serum omentin - 1 and Troponin I Fast, total cholesterol, triglyceride, High density lipoprotein cholesterol and low - density lipoprotein cholesterol, fasting blood sugar, serum creatinine and uric acid.Body mass index was calculated according to the following equation : BMI=weight/height2, also blood pressure was measured.Results : Serum vaspin and omentin - 1 levels were significantly lower in patients groups in comparison with control group, while serum Troponin I fast, total cholesterol, and low density lipoprotein cholesterol levels were significantly higher in patients with coronary artery disease than controls. Negatively significant correlation was found between serum vaspin and omentin - 1 with (BMI, total cholesterol and troponin I Fast).Conclusion : Serum Vaspin and Omentin - 1 levels were lower in acute coronary syndrome patients in comparison with control group, serum vaspin and omentin - 1 showed significant changes with the development and progression of acute coronary syndrome and would be valuable in the assessment of patients with acute coronary syndrome.Vaspin and Omentin - 1 may be used as a predictor of ACS.

دراسة فرط زيادة الانسولين بالدم والمتلازمة الايضية لدى مرضى داء السكري النوع الثاني A Study Of Hyperinsulinemia And Metabolic Syndrome In Patients With Type 2 Diabetes

اسم المؤلف: علي عبد اللطيف حسن
اسم المشرف: THABIT NUMMAN WAHID AL AZZAWE
الموضوع العام: الطب
السنة: 2008
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الكيمياء الحياتية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: مرض السكري من النوع الثاني هو اكثر اشكال مرض السكري شيوعا ويتميز باختلال افراز الانسولين واختلال فعاليته ويكون مصحوبا بمشكله زياده الممانعه للانسولين(وهي الحاله التي يكون فيها كميه الانسولين الطبيعيه تكون غير كافيه لانتاج نفس الفعاليه الايضيه في الخلايا | Type 2 diabetes is the most common form of diabetes and is characterized by disorders of insulin action and insulin secretion, and associated with increase problem of insulin resistant which is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells results in hydrolysis of stored triglycerides, which elevates free fatty acids in the blood plasma. Insulin resistance in muscle reduces glucose uptake, whereas insulin resistance in liver reduces glucose storage, with both effects serving to elevate blood glucose. High plasma levels of insulin and glucose due to insulin resistance often lead to metabolic syndrome.The combination of hypertension, dyslipidemia, insulin resistance, hyperinsulinemia, glucose intolerance, and obesity, particularly central obesity, has been termed the “metabolic syndrome.” It has been proposed that this syndrome is a powerful determinant of type 2 diabetes and cardiovascular disease.Material and measurements : The study is designed to measure BMI, FBS, TG, HDLc, and c - peptide and insulin level. history of hypertension, age of patients and duration of diabetes are Also taken in to account. These parameters and measures applied for forty five patients with diabetes and thirty normal as control subjects.Results : - There is a positive significant Correlation between insulin level of the diabetic patient and BMI - there is Also a positive significant correlation between insulin level and C - peptide in diabetic patient (r=0.781) (p=0.0001) and in healthy control (r=0.599) (p=0.0001). - There is a positive significant Correlation between C - peptide level of the diabetic patient and BMI - There is a significant negative correlation between HDL with HbA1c, in diabetic patient (r= - 0.423) (p=0.006) and significant correlation of HbA1c with FBS - There is a positive significant Correlation between duration of diabetes and age of the patient(r=0.783) (p=0.0001) - There is a significant negative correlation between C - peptide and duration of diabetes in diabetic patient (r= - 0.310) (p=0.045) - There is a significant correlation between TG with FBS values. - There is a negative significant correlation between TG with HDL values. - 37.8% of diabetic patients had metabolic syndrome and no one of the control subjects had the criteria of (WHO).Conclusion : There were large percentage of diabetic patients with different BMI had metabolic syndrome as compared with the control subjects. There were strong correlations between insulin level (hyperinsulinemia) and risk of metabolic syndrome development and appearance of its complications. The risk of hyperinsulinemia and metabolic syndrome was well correlated with BMI than with HbA1c. Most of over weight and obese patients had high insulin level with different degrees of glycemic control and duration of disease. Large number of patient with metabolic syndrome were hypertensive as compared with diabetic patients with out the syndrome.
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