اكتفين ا كعلامة بيولوجية للحمل خارج الرحم والاجهاض المنسي == Activin A As A Biomarker For Ectopic Pregnancy And Missed Abortion
Author name:
مي حامد حسن
Supervisor name:
نورهان شاكر
General topic:
Medicine
Specific topic:
Obstetrics and Gynecology
Degree:
Higher Diploma
University:
University of Kufa - Faculty Of Medicine - Department Of Obstetrics And Gynecology
Language:
English
University location:
Najaf
First pages:
19T1193 - p.pdf
Abstract:
Background : Activin A is a member of transforming growth factor B family that is secreted from ovary and placenta, however, in pregnancy the main source is the trophoblast.Aim of study : Activin A measurement to differentiate between intrauterine pregnancy and failed (missed abortion and ectopic) pregnancies.Study design : a Case control study.Setting : Department of Obstetrics and Gynecology in the College of Medicine Kufa University in Al Zahraa Teaching Hospital.Material and Methods : This study is a case control study consisting of 90 patients on three groups : Group 1 ectopic pregnancies (EP) (n=30) , Group 2 missed abortions (MA) (n=30) and Group 3 healthy viable intrauterine pregnancies (IUP) (n=30) were came to hospital with lower abdominal pain and\or vaginal bleeding or both between 6 - 8 weeks of gestation. Serum samples were sent at initial visit before treatment for measurement of activin A using ELISA test.Results : Activin A concentrations were significantly lower in women with EP (n = 30, mean value of 89.9 pg/mL) and women with MA (n = 30, mean value of 164.9 pg/mL) compared to IUP (n = 30, mean value of 334.5pg/mL); P < 0.001. Activin A can discriminate an ectopic pregnancy from viable pregnancies also, it was able to discriminate a MA from an EP.Conclusion : In this study activin A could be considered a promising biomarker for the discrimination between an IUP and a failed pregnancy (MA or EP).
