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دراسة مستوى الهيبسيدين ومستقبلات الترانسفرين في عينات من المرضى العراقيين المصابين بحالات فقر دم نقص الحديد واضطرابات زيادة الحديد في الدم == Study Of Hepcidin Level And Transferrin Level In Samples Of Iraqi Patients With Iron Overload And Iron Deficiency Disorders
Author name:
داليا نايف جاسم
Supervisor name:
علاء الدين مظفر زبير القاسم
General topic:
Medicine
Specific topic:
Diseases - Blood
Degree:
Master
University:
Mustansiriyah University
Language:
English
University location:
Baghdad
First pages:
19T1179 - p.pdf
Abstract:
The circulating peptide hepcidin is secreted mainly by the liver as an 84 - amino acid precursor that is subsequently processed and secreted as a 25 - amino acid peptide form. It is considered the "master regulator" of iron metabolism.Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin - iron complex through receptor - mediated endocytosis. This study addresses the physiological role of hepcidin in vivo and investigates the role of hepcidin as an erythroid regulator, contributing to the modulation of iron absorption by the intestine and iron release by the macrophages in the situation of anemia with normal or increased iron stores. Measuring the transferrin receptor level and it's relation to hepcidin is another part of the data involved in this study.Methods : This study included 64 Iraqi patients, 34 of them have iron deficiency anemia and the other 30 are iron overload patients. They attended the National Center of Hematology and Thalassemia center in Al - Karama Teaching Hospital during the period from October 2014 until April 2015 together with 30 healthy controls. Information regarding age, sex and clinical presentation were recorded. ELISA technique used to measure hepcidin and transferrin receptors level in patients and healthy control groups.Results : ? Mean serum hepcidin level in iron deficiency anemia patients was (205.3ng/ml) while in iron overload patients was (6.7ng/ml).? Mean serum level of transferrin receptors in iron deficiency anemia was (11006.3ng/ml) and in iron overload was (604.5ng/ml).Conclusion : ? The mean level of serum hepcidin in thirty iron deficiency anemia patients is high. Its elevation represented an acute phase response. While in thirty patients with iron overload, hepcidin mean level was low mainly due to stress erythropoiesis.? The current study result addresses the usefulness of soluble transferrin receptor for assessing high iron status in population and how soluble transferrin receptor is useful in the evaluation of anemic patients.
