مشاركة
المرضى المصابين بالمتلازمة الشريانية الحاد Vaspin and Omentin - 1 : تقييم مستويات == Evaluation Of Serum Vaspin And Omentin - 1 Levels In Patients With Acute Coronary Syndrome
اسم المؤلف:
مشتاق عبد هنيدي الطائي
اسم المشرف:
ولاء احمد الجدة | عباس ناجي الشريفي
الموضوع العام:
الطب
السنة:
2015
الموضوع الدقيق:
الكيمياء الحياتية السريرية
الدرجة:
ماجستير
الجامعة:
الجامعة المستنصرية - كلية الطب - قسم الكيمياء الحياتية
اللغة:
الانكليزية
مكان الجامعة:
بغداد
الصفحات الاولى:
19T1170 - p.pdf
المستخلص:
Acute coronary syndrome (ACS) is an insufficient supply of the myocardium with oxygenated blood in which atherosclerosis is an essential cause of myocardial ischemia. Adipokine biomarkers plays an essential role in the atherosclerosis and hence coronary artery disease. Serum Vaspin, Omentin - 1 and troponin I Fast are the biomarkers that believed to be independently associated with acute coronary syndrome.Objective : The study was carried out to evaluate : serum Vaspin,Omentin - 1 and Troponin I Fast in patients with acute coronary syndrome [ST - Elevation Myocardial Infarction(STEMI), Non - ST - segment Elevation Myocardial Infarction (NSTEMI),and Unstable Angina pectoris (UA)], that may help in guiding the diagnosis and treatment.Subjects, Materials and Methods : The study include a total (100) individuals; (75) patients with acute coronary syndrome (ACS) and (25) healthy control.A total number of 75 patients with acute coronary syndrome (ACS) (50 male ,25 female ) as : 25 patients with STEMI (22 male and 3 female) 25 patients NSTEMI(16 male and 9 female ) and 25 patients with unstable angina UA(12 male and13 female)were enrolled in this study all taken from Coronary Care Unit (CCU)at AL - Yarmouk Teaching Hospital.Each patient was clinically examined by the consultant cardiologist and the diagnosis was achieved by electrocardiograph (ECG), and cardiac enzyme levels.Venous blood sample (ten milliliters) was drawn from each patient and control after (10 - 12) hours overnight fasting, using a 10 ml disposable syringe between 9.00 and 11.00 A.M.The sample was divided into two portions one for testing Hb concentration and the other part was centrifuged to obtain serum, to be used for measuring the following variables : serum vaspin, serum omentin - 1 and Troponin I Fast, total cholesterol, triglyceride, High density lipoprotein cholesterol and low - density lipoprotein cholesterol, fasting blood sugar, serum creatinine and uric acid.Body mass index was calculated according to the following equation : BMI=weight/height2, also blood pressure was measured.Results : Serum vaspin and omentin - 1 levels were significantly lower in patients groups in comparison with control group, while serum Troponin I fast, total cholesterol, and low density lipoprotein cholesterol levels were significantly higher in patients with coronary artery disease than controls. Negatively significant correlation was found between serum vaspin and omentin - 1 with (BMI, total cholesterol and troponin I Fast).Conclusion : Serum Vaspin and Omentin - 1 levels were lower in acute coronary syndrome patients in comparison with control group, serum vaspin and omentin - 1 showed significant changes with the development and progression of acute coronary syndrome and would be valuable in the assessment of patients with acute coronary syndrome.Vaspin and Omentin - 1 may be used as a predictor of ACS.
