Author name:
سارة عاشور ساير
Supervisor name:
رائد معلك حنون الصالح | عدنان الطعان الخفاجي
Abstract:
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the general population, and a major cause of morbidity and mortality. Lifetime risk for development of AF has been estimated to 1 in 4 in individuals aged 40 years or more.The present study is designed to determine the levels of oxidative stress by measuring lipid peroxidation product (malondialdehyde MDA), antioxidant state by measuring some antioxidants such as (ceruloplasmin Cp, Transferrin Tf, albumin Alb ,uric acid Ua) ,in addition to lipid profile (cholesterol TC, triglyceride TG, high density lipoprotein cholesterol HDL - C, low density lipoprotein cholesterol LDL - C and very low density lipoprotein cholesterol VLDL - C) in atrial fibrillation patients .The study included (150) subjects; (75) normal subjects (control) and (75) patients with atrial fibrillation. The patients are divided into two groups according to the age : (39) elderly patients [the age range (60 - 80) years] and (36) others patients [the age range (20 - 59) years], also patients are divided in to two groups according to the age with one or more risk factor (Hypertention (HTN), Ischemic Heart Disease(IHD), Heart Hailure (HF)) : elderly which included (18) patients (lone AF) , (21) patients (AF with HTN, IHD, HF) and others which included (17) patients (lone AF), (19) patients (AF with HTN, IHD, HF).The normal subjects (control) also divided into two groups according to the age : elderly [the age range (60 - 80) years] and others [the age range (20 - 59) years] .According to age, the results shown significant increase in the concentration of serum (MDA, Cp, uric acid, TC, TG, VLDL - C, LDL - C ) in elderly and other groups in comparison with their control groups (p≤0.05). It was found significant increase in the concentration of serum MDA in elderly group in comparison with other group, also it was found significant increase in the concentration of serum uric acid in control elderly group in comparison withXIVcontrol other group (p≤0.05). The results also showed non significant differences in the concentration of serum (Cp, uric acid, TC,TG, LDL - C, VLDL - C) between elderly and other groups. It was also found non significant differences in the concentration of serum ( Cp, TC, TG, LDL - C, VLDL - C) between control elderly and control other groups (p≤0.05). While serum Alb , serum Tf and serum HDL - C concentrations show a significant decrease in elderly and other groups in comparison with their control groups (p≤0.05). The results showed significant decrease in the concentration of serum HDL - C in control elderly group in comparison with control other group. Also there were no significant differences in the concentration of serum Alb serum Tf and serum HDL - C between elderly and others groups (p≤0.05).According to the age with one or more risk factor (HTN, IHD, HF) the results show a significant increase in the concentration of serum (MDA, Cp , uric acid, TC, TG, VLDL - C , LDL - C ) in elderly and other groups in comparison with their control groups (p≤0.05). It was found a significant increase in the concentration of serum MDA in the groups AF and AF with HTN, IHD, HF ( in elderly groups) in comparison with groups AF and AF with HTN, IHD, HF (in other groups) respectively (p≤0.05). It was also found a significant increase in the concentration of serum uric acid in control elderly groups in comparison with control other groups , also there were no significant differences in the concentration of serum (CP ,TC , TG ,VLDL - C, LDL - C) between elderly and other groups (p≤0.05). serum Alb ,serum Tf and serum HDL - C show a significant decrease in elderly and other groups in comparison with their control groups, also there was significant decrease in the concentration of serum HDL - C in control elderly groups in comparison with control other groups (p≤0.05). It was also found non significant differences in the concentration of serum Alb and serum Tf between elderly and other groups (p≤0.05).
