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العلاقة بين تجارب الطفولة السيئة والمطاوعة على الصحة بعد البلوغ في بغداد The Relationship Of Adverse Childhood Experiences And Resilience To Adult's Health In Baghdad City

اسم المؤلف: اميل فاروق الشاوي
اسم المشرف: رياض خضير لفتة صالح الحسناوي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: طب المجتمع
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تجارب الطفولة السيئة تشير الى اكثر مصادر الاجهاد شيوعا وشدة التي يعاني منها الاطفال في حياتهم المبكرة. من هذه الخبرات الاساءة، الاهمال، العنف بين الابوين او مقدمي الرعاية والعنف المجتمعي. وتبين ان الاجهاد الطويل في الطفولة له اثار طيلة الحياة على صحة | Adverse Childhood Experiences refer to some of the most intensive and frequently occurring sources of stress that children may suffer early in life. Such experiences include multiple types of abuse; neglect; violence between parents or caregivers and community violence exposure. It has been shown that prolonged stress in childhood has life - long consequences for a person's health and well - being; it may lead to serious problems such as alcoholism, depression, eating disorders, heart diseases, cancer, and other chronic diseases. Resilience is the ability to manage crises, difficult situations and developmental tasks. Research on resilience has identified several factors that strengthen the power and resources of children as well as promote their abilities to cope successfully with crises and internal and external problems. This cross - sectional study was conducted to estimate the effect of adverse childhood experiences and resilient factors on adults’ heath. It was done during the period from January 2013 through January 2014. The study sample was drawn from Baghdad City. Multistage sampling technique was used to choose 13 primary health care centers and eight colleges from three universities in Baghdad; the questionnaire was filled through a direct interview with the participants. In addition to that, teachers of seven primary schools and two secondary schools were chosen by a convenient method. A total of 1040 subjects were surveyed and 1000 responded. Their age ranged between 18 to 59 years (32.08±11.169). Females constituted a higher proportion (58.3%) of the study sample, 60% of this sample had university/diploma as the highest level of education. The results showed (during childhood) that seeing or hearing a parent or household member in home being yelled at, screamed at, sworn at, insulted or humiliated was reported in 469 (46.9%). A parent, guardian or other household member yelled, screamed or swear at, insulted or humiliated them was registered in 387 (38.7%). A parent, guardian or other household member spanked, slapped, kicked, punched the subjects was seen in 335 (33.5%). father's death (when the subject's age was 15 years or less) was reported in 104 (10.4%) of the participants, and 74.8 % of the subjects like to be the kind of people their parents were. The multiple linear regression models demonstrated that being in the fourth quartile (highest quartile) of household dysfunction - abuse score is expected to significantly increase depression symptoms score by a mean of (10.4) compared to subjects in the lowest (first quartile) of household dysfunction - abuse score, being in the fourth quartile of family bonding score is expected to significantly decrease depression symptoms score by a mean of ( - 22.5) compared to subjects in the first quartile, the same is correct for self - esteem score which increases by a mean of (21.484) for the fourth quartile of family bonding score compared to subjects with lowest (first quartile) after adjusting other explanatory variables. Logistic regression model showed that being in a higher level of family bonding (fourth quartile) is expected to reduce the risk of having chronic physical diseases by almost the half (odds ratio =0.57) and being exposed to a high level of household dysfunction and abuse (fourth quartile) is expected to increase the risk of having chronic physical diseases by 81%. A positive history of suicidal attempts showed a strong positive association with mean score of household dysfunction and abuse. Family bonding during childhood appears to be the most important resilient factor that protects adults against sedative or narcotic usage, mental disorders, suicide attempts, and chronic physical diseases during adulthood. Higher levels of exposure to adverse childhood experiences have a positive association with substances usage, suicide attempts, symptoms of mental disorders and chronic physical diseases in adulthood.

قياس وتفسير وامكانية الاستخدام السريري لتشتت فترات QT والمعلمات لتخطيط صدى القلب في مرضى مرض القلب الاقفاري Measurement, Interpretation, And Use Of Clinical Potential Of QT Dispersion And Intervals With Echocardiographic Parameters In Patients With Ischemic Heart Disease

اسم المؤلف: فراس عبد الودود عبد العزيز
اسم المشرف: تقي علي موسى الموسوي الواجدي بسام طالب فائق الكيلاني
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الفيزياء الطبية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجري تخطيط القلب الكهربائي واخذت نتائج فحص الايكو لاربعة وخمسون مريض (اناث وذكور)، عمرهم المتوسط كان 51,1 ± 6,7 سنة؛ المدى كان يتراوح بين 35 - 66 سنة. المرضى الذي جندوا في الدراسة الحالية صنفوا الى اربع مجموعات : مرضى القلب الاقفاري الشرايين التاجية لوحده | ECG traces were recorded and echo findings were obtained for 54 patient (females were 15 and males were 39), their mean age was 51.1 ± 6.7 years; the range was 35 - 66 years. Patients that were recruited in the present study were classified into four groups : Patients with Ischemic Heart Disease (IHD) alone were labeled as group 1, Patients with IHD and Hypertension (HT) were labeled as group 2, Patients with IHD and diabetes mellitus (DM) were labeled as group 3, and Patients with IHD, HT, and DM were labeled as group 4. Fourteen age - matched apparently healthy subjects (mean age 48.6 ± 4.0 years) were chosen for comparison with group 1 patients. Patients' ECGs didn't show clear IHD before Treadmill test. Patients who showed clear ischemic changes within the treadmill test or during the rest time after completion of the treadmill test were sent to echo unit for structural / functional assessment of their hearts. Before stress test, simultaneous resting 12 lead ECG, arterial blood pressure, heart rate, height and weight of the patients were measured, age were recorded, smoking habit, and history of any cardiovascular disease. QT (The time interval measured from Q - wave onset the end of the T - wave), QT peak (The time interval measured from the Q - wave onset to the peak of the T - wave), TpTe (The time interval measured from the peak to the end of the T - wave)intervals were measured manually by tangent method on resting ECG. The dispersion of QT, QTp, TpTe intervals determined by the difference between minimal and maximal of these above measured intervals within 12 leads. The measured QT intervals were corrected for the subject's heart rate by using the standard Bazett's formula. In comparison with healthy subjects, QT dispersion (QTd) and QT peak dispersion (QTpd) of patients in group 1 were significantly higher (by 29% and 25% respectively) relative to their counterpart dispersion of healthy subjects, Tpeak - Tend dispersion (TpTed) of patients in group 1 was significant lower by 57% than TpTed of healthy subjects, QT interval and QTp interval of patients in group 1 was significantly longer (by 5% and 18% respectively) relative to their counterpart intervals of healthy subjects, in contrast, TpTe interval of patients in group 1 was significantly lower (by 27%) relative to their counterpart in healthy subjects. QT - intervals of patients in group 2, 3, and 4 are significantly higher (by 2%,4%, 3%) respectively than patients in group 1. QTp interval of group 3 was significantly higher than group 1, 2, and 4 by (4%, 6%, 4% respectively). No significant differences were observed in QTp interval among group 1, 2, and 4. TpTe interval of group 2, group 3, and group 4 patients were significantly longer by (16%, 6%, 14%) respectively relative to the TpTe interval in patients of group 1. QTd of patients in group 4 is significantly higher by (30%) than QTd of patients in group 1. QTp dispersion of group 4 is significantly higher by (26%) relative to QTp dispersion of group 1. TpTed of group 2 and group 4 were significantly higher (62% and 46% respectively) than TpTed of patients in group 1. LVMI of patients in group 2 and 4 were significantly higher (by 38% and 51% respectively) over the LVMI in patients of group 1. RWT of patients in group 2 and 4 were significantly higher (by 13% and 17% respectively) over the RWT of patients in group 1. PWT of patients in group 2, 3, and 4 was significantly higher (by 15%, 18%, and 21% respectively) over their PWT counterpart of patients in group 1. IVSTS was found to be significantly higher by (19% and 20%) of patients in group 2 and 4 respectively relative to patients in group 1. IVSTD was significantly higher by 24% in patients of group 4 only relative to the IVSTD of patients in group 1. IVSTS and IVSTD were significantly correlated with the QTd and QTpd in group 1. In group 2 patients RWT and PWT were significantly correlated with QTd and QTpd and IVSTD was significantly correlated with QT, QTp, and TpTe interval. In group 3 patients, IVSTD, ARD, and BMI were found to be significantly correlated with QTd and QTpd. significant correlation also was found in this group between RWT and QTp interval and IVSTS was correlated significantly with the QT and QTp intervals in group 4 patients.

دراسة تاثير اديبونكتين على هيكل كبد الفئران وعلاقته بالنظام الغذائي وكمية الدهون في الجسم A Study Of Adiponectin Effects On The Mice Liver Architecture In Relation To Dietary Intake And Body Fat Content

اسم المؤلف: غسان علي عبد الحسین
اسم المشرف: سلمان شفیق سلمان عماد غانم قاسم
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: التشريح والانسجة والاجنة
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: يعتبر مرض الكبد الدهني غير الكحولي الاضطراب المزمن الاكثر شيوعا في الكبد واصبح تشخيصه في ازدياد مع زيادة وباء السمنة العالمي وقد تم تصميم الدراسة الحالية لدراسة الفوائد المحتملة للاديبونيكتين على النماذج الحيوانية من مرض.تم تطوير نموذجين من اضطراب الكبد | Non - alcoholic fatty liver disease is the most common chronic liver disorder whose prevalence has been on the rise with the worldwide increasing pandemic of obesity. The current study was designed to study potential benefits of the adipokine (adiponectin) on animal models of non - alcoholic fatty liver disease.Two models of the disorder were developed using two different approaches. In experiment 1 (25 mice, last 8 weeks), fatty change was induced using high fructose intake to simulate human - like diet induced obesity and fatty liver disease. In experiment 2 (25 mice, last 3 weeks), fatty liver damage was induced by using methionine - choline deficient diet. Animal body weights, absolute and relative liver weight, food consumption and fructose water consumption were recorded. Visceral (epididymal) fat and liver tissue were studied using routine hematoxylin and eosin staining and histochemical stains including Masson trichrome, Periodic acid schiff and reticulin stains. Morphological and morphometric changes were compared between animals treated with adiponectin, untreated diseased animals, and control healthy animals and a non - alcoholic steatosis activity score was used to evaluate the severity of liver damage. Random blood sugar and serum lipid levels were also included as biochemical metabolic parameters.High fructose intake resulted in larger visceral fat depots and weight gain, effects that were combated by adiponectin treatment despite increased food intake. Hepatic steatosis, inflammation, pyknotic pictures and fibrosis were reduced in adiponectin treated animals resulting in a lower activity score. Random blood sugar levels were normal in all animal groups but were significantly lower in adiponectin treated groups. TG and VLDL were alleviated with adiponectin treatment.Methionine - choline deficient diet resulted in emaciation of animals, much reduced visceral fat depots but a more severe form of liver fatty damage over a shorter period of time when compared to high fructose obese animal models. Weight loss was worsened after adiponectin treatment. Hepatic steatosis, inflammatory foci, ballooning degeneration and fibrosis were all exaggerated but remained significantly less severe with less activity score in adiponectin treated animals. Random blood sugar levels were normal in all animal groups but were significantly higher after adiponectin treatment. TG and VLDL was alleviated with adiponectin treatment.Adiponectin affects appetite, food consumption and body composition in healthy animals and animal models of non - alcoholic fatty liver disease through different mechanisms. It has beneficial effects in reducing body weight in obese animals but can modulate weight loss in lean animals on methionine - choline deficient diet. Adiponectin has autocrine/paracrine effects on visceral adipose tissue and can correct the dyslipidemic picture of fatty liver disease. The antisteatotic and antifibrotic effects of adiponectin carry greater therapeutic potentials in obesity - related liver disease.

هرمون اللبتين والاستقلاب : دراسة كيميانسيجية وكيمياحيوية شاملة في الحيوانات الطبيعية والمصابة بالسكري Leptin And The Metabolism : A Comprehensive Histochemical And Biochemical Study In Healthy And Diabetic Animals

اسم المؤلف: سامح سمیر موسى عكیلة
اسم المشرف: سلمان شفیق سلمان سامیة عباس علیوي
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: التشريح والانسجة والاجنة
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The adipocytokine leptin is a major player in the pathogenesis of diabetes mellitus and obesity. Since its discovery around 20 years ago, leptin has been; and still is; the subject of extensive research.The current study was designed to examine the effects of physiological doses of leptin on major organs involved in metabolism. The anatomical, histochemical, physiological, and biochemical effects of leptin were studied in healthy animals and in animal models of type 1 and type 2 diabetes.Eighty male albino mice were divided into three groups. The first group (A) consisted of healthy non - obese non - diabetic animals, a subgroup (A1) of which received leptin therapy to study its effects under normal conditions without metabolic disturbances. In the second group (B), a model of diet induced obesity and insulin resistance was developed using a combination of high fat diet and low dose streptozocin injection. In one subgroup (B1), the effects of leptin were studied under dietary manipulation after the discontinuation of high fat diet. In other subgroups, leptin effects were examined with continuous HFD with (B3) and without (B2) concomitant metformin therapy. The third group animals (C) represented a type 1 DM model developed by high dose streptozocin injection. A subgroup (C3) served as model control, not receiving any hormonal therapy. The others two subgroups received leptin treatment with (C2) and without (C1) concomitant insulin therapy.Statistical parameters for the study included the body weight, food and caloric consumption, adiposity index and specific organ weights and weight ratios. The epididymal fat pad, liver and pancreas were examined for gross anatomical and histological changes. Adipose tissue and some pancreatic sections were stained with H&E, liver sections were stained with periodic acid schiff stain, other pancreatic sections were stained with modified Gomori's aldehyde fuchsin. Random blood sugar and serum lipid levels and insulin tolerance test were also studied as biochemical parameters.Leptin therapy in healthy non - obese animals resulted in a reduction in food consumption, body weight, adiposity index and white fat pads weight. It also caused a reduction in the diameter and surface area of epididymal adipocytes. Serum TGL and LDL levels were significantly reduced. iiiThe same effects were seen in group B animals that underwent dieting or received metformin, but not in ones receiving leptin alone. Animal models of type 1 DM showed a moderate response to leptin therapy alone but the response was dramatically enhanced when treatment was combined with insulin. Sever weight loss and polyphagia of type 1 DM were greatly ameliorated by leptin therapy and there was an improvement in fat pad weights and adipocyte measurements. The hepatic glycogen content and insulin sensitivity were greater in animals treated with leptin (A1), on diet and leptin (B1) or metformin (B3) and in animals on leptin with insulin (C1). This was associated with significantly lower levels of random blood sugar. The pancreatic islet surface area was markedly reduced while the ? - cell/ ? - cell ratio was increased in treated animals.Leptin therapy can alter body weight and adiposity index by affecting appetite and food consumption via central and peripheral mechanisms involving the control of feeding behavior and manipulating the processes involved in carbohydrate and lipid metabolism. It can also correct the metabolic disturbances of type 2 DM but requires the concomitant use of metformin and/or the manipulation of dietary content of fat and carbohydrates. Much of its influence arises from its ability to enhance insulin sensitivity.Leptin also has a sparing effect on hepatic glycogen, favoring in turn the use of fatty acids for energy expenditure. Leptin effects on blood glucose are insulin dependent in most cases but can be insulin - independent in type 1 DM by utilizing alternative metabolic pathways for energy expenditure and interacting with hyperglycemia - inducing hormones.

التعدد الشكلي للمستقبل الثاني لعامل الورم التنخري والجين المحفز للـ CD4 والانترلوكين 37 في تقييم التهاب المفاصل الرثوي Tumor Necrosis Factor Receptor II, Cd4 Enhancer Gene Polymorphisms And IL - 37 In Assessment Of Rheumatoid Arthritis

اسم المؤلف: وسناء جمعة محمد
اسم المشرف: محمد شمخي جبر باسم شهاب احمد
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: التهاب المفاصل الرثوي (Rheumatoid Arthritis) مرض جهازي التهابي مزمن يصيب المفاصل وتحديدا الاغشية الزلالية والتراكيب المفصلية، والذي يحدث للعديد من الناس وبنسبة تقارب 0.5 الى 1% من السكان في العالم. لوحظ خلال الدراسات الوبائية لمرض التهاب المفاصل الرثوي | Rheumatoid arthritis (RA) one of the most common systemic autoimmune diseases characterized by chronic joint inflammation and subsequent joint destruction. To date, it well known that RA is characteristic of the expansion of the synovium and infiltration of the inflammatory cells coupled with destruction of adjacent articular cartilage and bone. This is strongly dependent on CD4 T cell. CD4 Cells stimulate monocytes, macrophages, synovial fibroblasts, and other cells to produce cytokines such as tumor necrosis factor - ? (TNF - ?, interleukin - 1 (IL - 1), IL - 6, IL - 15, IL - 17 and metalloproteinases that produce tissue damage. TNF is a major inflammatory cytokine contributing to the pathogenesis of RA, which provides rational for development of anti - TNF biological agents in the treatment of RA.Recently have shown that IL - 37 is a key cytokine in regulating inflammatory response, mainly by inhibiting the expression, production, and function of proinflammatory cytokines. Objectives This study planned to evaluate the association of TNFRII and CD4 enhancer genes polymorphisms in development and severity of RA in Iraqi patients, evaluate IL - 37 in patients with RA and investigate the correlation between IL - 37 levels with disease activity and relation of inflammatory parameters (ESR, CRP, ACPA, and RF) with TNFRII, CD4 enhancer genes polymorphisms.Patients and methods This study was performed during the period from May to September 2015. The patients were attending the out patients' Clinic in Medical City/Baghdad Teaching hospital/rheumatology unit and the laboratory ELISA tests were done in nursing home hospital laboratory, polymerase chain reaction (RFLP) analysis was performed in the specialist private molecular laboratory (ASCO Lab) in Al - Harthia / Baghdad. Fifty patients and 50 apparently healthy control individuals, Patients received disease modifying anti rheumatic drugs (DMARDs) and newly diagnosed patients.The diagnosis of RA patients has performed under the supervision of rheumatic disease consultant physician at the consultation clinic of Baghdad teaching hospital of the medical city. Blood samples had taken from RA patients to measure (ESR), white blood cells count and hemoglobin. Also, analyze the serum levels of ACPA, RF screen CRP and estimate the levels of IL - 37 in patients and healthy individuals using ELISA test kits. TNFRII and CD4 enhancer genes polymorphisms genotyping had achieved by polymerase chain reaction restriction fragment length (PCR - RFLP).Results The results showed the estimation of RF by screening test revealed that its mean level was high among RA patients (168.87+31.62) in comparison with apparently healthy control (4.96+0.71) with highly significant difference (p<0.01). There was a higher positivity of Anti CCP in the patients sera (114.85+21.06) in comparison with apparently healthy control (1.71+0.13) (P<0.01). while the estimation of CRP showed that its level was higher among sera of RA patients (38.39+4.31) in comparison with healthy control group (16.49+2.51) (P<0.01). Furthermore, the ESR level in RA patients were higher than apparently healthy individuals (52.96+3.68) and (10.44+0.74) respectively with significance (P<0.01).The frequencies of the MM, MR, RR genotypes of TNFRII gene polymorphisms were 60%, 32%, 8% in RA patients and 52%, 42%, 6% in controls. There were no significant differences in the genotypes frequencies polymorphisms of the TNFRII 196 MR polymorphism between apparently healthy control and RA. The frequencies of AA, AG, GG genotypes of CD4 10845 A/G in patients was 36%, 42%, 22% and 8%, 44%, 48% in control group. There were significant differences in the genotypes frequencies polymorphisms of the CD4 10845A/G polymorphisms between apparently healthy control and RA patients (p<0.01). AA genotype were significantly more likely to develop RA (OR=1.355). There was significant increase in disease activity and severity in patients carries AA genotype (p<0.01).IL - 37 levels were elevated markedly in RA patients (101.31+10.41) compared with apparently healthy control (43.90+0.91) (p<0.01). More importantly, IL - 37 showed a significant correlation with disease activity (CRP) in RA patients (p<0.05). Also, IL - 37 show non - significant relationship with (MM, MR, RR) exon6 TNFRII in RA patients compared with controls, and non - significant difference between level of IL - 37 with CD4 10845 A/G genotypes compared with healthy control.Conclusion All findings suggested that TNFRII - 196R genotypes not associated with RA diagnosis. In addition, genetic polymorphisms at the CD4 enhancer gene are one of important factors that associated with susceptibility and severity of RA and can serve as a genetic marker for the risk of development of RA.

دورا محتملا لفيروس ابشتاين بار في عملية تسرطن الغدة الدرقية الحليمية A Possible Role Of Epstein - Barrvirus In Carcinogenesis Of Papillary Thyroid Carcinoma

اسم المؤلف: هند علي خميس
اسم المشرف: عامر رشيد النجار سعد حسن محمد علي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: This study was designed as a retrospective research. A total number of (90) formalin - fixed, paraffin embedded tissues were studied. Malignant and normal thyroid tumors tissue blocks were collected from the archives of histopathology laboratories of different general hospital including ALYarmouk Teaching Hospital (Baghdad), Baghdad Medical City Teaching Hospital as well as many private laboratories in Baghdad, during the period from May 2013 to May 2014. These cases include ? Thirty tissue specimens from patients with papillary thyroid cancer. ? Thirty tissue specimens with benign thyroid lesions as control thyroid tissues group. ? Thirty (30) thyroid specimens were obtained from the normal thyroid tissues from the same those totally - thyroidectimized patients for thyroid papillary cancer (PTC) and have served as the second control group for this study. This study was therefore a paired case - control design. The sections were stained by hemotaxyline and eosin staining so as to confirm the diagnosis and assure that the intervening sections ( that were specified for the in situ hybridization and Immunohistochemistry study have containing the questioned tissues from papillary thyroid cancers and benign thyroid tissues (control group).After histopathological sectioning of these thyroid gland tumors and staining by Hematoxylin and Eosin, a final definitive diagnosis was done by histopathologist consultant. The practical part of this study was designed in four pathways : 1. Molecular detection of Epstein - Barr virus in those tissue blocks were performed by using ultra - sensitive version of in situ hybridization (ISH) for detection of EBV - EBERs. 2. To perform immunohistochemical study to demonstrate EBV - latent gene (LMP1, EBNA - 2) in the papillary thyroid cancer compared to control group. 3. To perform immunohistochemical screening study to demonstrate the over expression state of p53 - tumor suppressor gene in those tissues with papillary thyroid cancer compared to control group. 4. To perform immunohistochemical screening study to detected the CD8 and CD56 in tissues with papillary thyroid cancers compared to control group. The obtained results are summarized as follows : 1. The mean age of patients with papillary thyroid cancer and simple nodular goiter was (39.87&41.13) years respectively, with standard deviation ±(11.773,9.243) years. 2. In this study, the percentage of the females with papillary thyroid cancer was higher (86.7%; 26 cases) than the percentage of their PTC - male counter parts (13.3%; 4 cases). The patients whom sub totally thyroidectimized for simple noduler goiters , the percentage of females was also higher (73.3%; 22 cases) than the percentage of their male counter parts with simple noduler goiters ( 26.7%; 8cases). Female / male ratios of the patients with PTC and simple noduler goiters were 6.5 and 2.75 respectively. 3. The percentage of EBV results in the total group of PTC was (50%) while the percentage in the total group of normal thyroid tissue was (26.7%) and lastly in the total simple nodular goiter group was (10.0%). 4. The positivity rate of EBV EBERs - ISH technique in the total group of PTC was (30%), where as its percentage in NTT tissues was (16.7%) and in SNG tissues was (3.3%). 5. The percentage of positive - EBNA - 2 IHC technique in the total group of PTC was (20%), where as its percentage in NTT tissues was (10.0%) and in SNG tissues was (6.7%). 6. The percentage of positive - EBV - LMP - 1 - IHC technique in the total group of PTC was (43.3%), where as its percentage in NTT tissues was (20.0%) and in SNG tissues was (6.7%). 7. Mutated P53 - protein was detected in 28 cases (70%) of the studied cases. Twelve cases (30.0 %) showed negative IHC reactions. 8. The highest total percentage of CD8 - IHC reactions (21 cases; 70%) was found in those with papillary thyroid cancer followed by normal thyroid tissues cases ( 5 cases; 16.7%) and then ( 2 cases : 6.7%) in simple nodular goiter. 9. It was found that the highest percentage of CD56 - IHC reactions was in those with normal thyroid tissues (25 cases; 83.3%) followed by an equal percentages of CD56 - IHC reactions in either thyroid papillary or simple nodular goiter (2 positive cases; 6.7%, each). 10. The importance of CD56 marker has been found to play a role or it may be better to be used as a negative - diagnostic biomarker for papillary thyroid cancer in differentiating it from other malignancies as well as benign lesions of the thyroid gland, individually as well as in combination with other markers for clinical evaluation of those patients. 11. The evident high mutated p53 - over expression, as reflected by abnormal gene product, among papillary thyroid cancer patients indicates for a pivotal role of such genetic mutation in their carcinogenesis as well as could be useful in the clinical evaluation of patients with papillary thyroid cancer, too. 12. The high coexistence of p53 - mutation with EBV in PTC could point for participation of EBV - transformation genes in the p53 activation in high proportion of PTC. 13.The high percentage of CD8 lymphocytes in EBV - positive PTC as compared to their EBV - negative counterparts could reflect the participation of specific cellular immunity against both, the papillary thyroid cancers and this EBV infection during the initiation and progression of EBV - associated papillary thyroid cancers.

تشخيص مصلي وجزيئي لفيروس الحلا البشري النوع السادس المصاحب لبعض سرطانات الدم Serological And Molecular Detection Of Human Herpesvirus Type 6 Associated With Certain Hematologic Malignancies

اسم المؤلف: هديل محمد فياض
اسم المشرف: علاء فاضل علوان داود سلمان داود
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Human herpesvirus 6 (HHV - 6) is largely ubiquitous double stranded DNA viruses within the betaherpesvirinae subfamily and of the genus Roseolovirus.HHV - 6A and HHV - 6B infects very high percentage of population around the world, primarily during childhood through respiratory droplets. HHV - 6 has been found out in many types of cancers : lymphomas, leukemia, cervical cancer, and brain tumors.This cross - sectional case control study was carried out in Baghdad Teaching Hospital and National Center of Hematology - AL - Mustansiriyah University - Baghdad, for the period from 1 September 2013 to 1 April 2015.The aims of the study were to explore the seropositivity rate of HHV - 6 antibodies among Iraqi patients with different hematological malignancies using different laboratory assays, beside, the molecular determination of plasma viral DNA load by quantitative polymerase chain reaction (qPCR).The study included 109 patients with different hematological malignancies; 24 patients with acute lymphoblastic leukemia (ALL), 30 patients with acute myeloid leukemia (AML), 11 patients with Hodgkin lymphoma (HL), 39 patients with non hodgkin lymphoma (NHL) and 5 patients with chronic lymphocytic leukemia(CLL). All patients were newly diagnosed and enrolled before receiving chemotherapy. The age range was between 14 - 80 years. Fifty three (48.6%) and 56 (51.4%) patients were males and females, respectively. The diagnosis of their malignancies was based on either bone marrow aspirate biopsy and lymph node biopsy as well as cytochemical investigations. Additionally, 59 apparently healthy blood donors were enrolled as control group. The age range was between 18 - 59 years, twenty eight (47.4%) and 31 (52.6%) were males and females, respectively.The serum anti - HHV - 6 IgG was detected by indirect immunofluorescent technique (IFAT) as well as by enzyme linked immunosorbant assay (ELISA).While, the serum anti - HHV - 6 IgM was detected by ELISA only. The detection and quantification of plasma viral DNAemia was carried out by quantitative polymerase chain reaction. Serological as well as molecular assays were done in Central Public Health Laboratory in Baghdad. The highest IFAT positivity rate was among patients with CLL (100%), followed by patients with AML (83.3%), and the least positivity rate was among patients with NHL (64.1%) compared to that of healthy control. Generally, the total anti - HHV - 6 IgG by IFAT was insignificantly higher among patients compared to healthy controls (74.3% vs 61.0%, p=0.074). The anti - HHV - 6 IgG positivity rates by ELISA were insignificantly higher in all groups of haematological malignancies except in patients with AML in whom it was significantly higher compared to healthy controls (96.7% vs 72.9%, p= 0.007 ). A part from AML, the highest anti - HHV - 6 IgG by ELISA was among patients with ALL (87.5%) followed by patients with NHL (84.6%), and the least was among patients with CLL (80.0%) compared to healthy control. Generally, the total anti - HHV - 6 IgG positivity rate detected by ELISA was significantly higher compared to IFAT in patients (p= 0.013) as well as in healthy control (p= 0.0005).The results of anti - HHV - 6 IgM positivity rate as detected by ELISA was significantly higher in patients with AML (36.7%, p=0.0004), and patients with HL (27.7%, p= 0.038) compared to healthy controls (6.8%). Whereas, other groups of hematological malignancies showed insignificantly higher positivity rate versus control group. However, the highest positivity rate was among patients with AML (36.7%), and the least positivity rate was among patients with CLL (0%). Generally, the total ELISA anti - HHV - 6 IgM positivity rate was significantly higher in patients versus healthy controls (22.0% vs 6.8%, p= 0.011). The results of PCR showed that 5 out of 109 patients had detectable HHV - 6 DNA in the plasma. The highest detection rate was among patients with HL (27.3%), followed by patients with ALL (4.2%), and then patients with AML (3.3%), while the virus was not detected in other disease categories as well as in healthy controls. The plasma viral load (mean ± SD) among the three Hodgkin lymphoma patients was 1.4± 0.3*102 particle/milliliter.The study concluded that the seropositivity rate of HHV - 6 infection is highly prevalent among Iraqi patients with hematological malignancies compared to healthy population. However, primary or reactivation infection as determined by anti - HHV - 6 IgM in patients as well as healthy individuals is relatively low. Furthermore, the HHV - 6 DNA detection rate as well as plasma viral load among malignant patients before receiving immunosuppressive treatment were low.

دراسة Toll like receptors(TLR2& ( 4 ومؤشرات حيوية مختارة في المرضى المصابين بسرطان المثانة Study Of Toll Like Receptors (TLR - 2 And 4) And Selected Biomarkers In Bladder Cancer Patients

اسم المؤلف: هدى سعدون البياتي
اسم المشرف: ميسون علي سليم ناهي يوسف ياسين عصام سلمان العزاوي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Worldwide, cancers of the urinary bladder are complex and involve genetic abnormalities and may be due to different environmental chemical carcinogens, as well as chronic infection like Schistosomiasis, all these will allow normal transitional cells to become cancerous which are typically transitional cell carcinoma(TCC).This study was conducted at AL - Yarmouk and Baghdad Teaching Hospitals in Baghdad from June 2013 to April 2014, of which urine and bladder tissue were taken from 57 bladder cancer patients and 80 controls to assess Interleukin - 8 (IL - 8), Matrix MetalloPeptidase - 9 (MMP - 9), Bladder Cancer - Associated Protein (BLCA - 4),Toll - Like Receptors (TLR - 2and TL - R4) level among them and to evaluate their roles in cancer development.One hundred thirty seven Iraqi individual were divided to 28(20.43%) newly diagnosed and 29(21.16%) recurrent bladder cancer patients (relapse), 40(29.19%) apparently healthy volunteers and 40(29.19%) autopsies (apparently normal urothelium), of whom urinesample and tissue biopsy were collected, clinical diagnosis of patients carried out by cystoscopic and histopathological examination, the mean ±SD age of bladder cancer patients were (63± 9.3) with (M : F ratio7.1 : 1).Predominant cancer type was Transitional cell carcinoma (TCC). According to risk factors of bladder cancer, out of 57 bladder cancer patients, 34(59.64%), 29(50.87%), 9(15.78%), 7(12.28%), 6(10.52%) were smoker, had UTI, history of Schistosomiasis, family history ofcancer and stones respectively. In this study 30 patients had non - muscle invasive bladder cancer, most of them (21) had newly diagnosed tumors, and only 9 had recurrent disease, as well as, 27 patients with muscle - invasive bladder tumor, just 7 had newly diagnosed tumors and 20 with recurrent disease.According to the result of ELISA technique, the mean±SD urine level IL - 8(pg/ml) for recurrent bladder cancer patients was 359.6±170.1pg/ml, for newly diagnosed was 265.95±139.09pg/ml and for healthy volunteers was 62.04±37.66pg/ml. The mean ±SD concentration of urine MMP - 9(pg/ml) was 7368.3±1730.19pg/ml for recurrent, 6176.8±2366.9 pg/ml for newly diagnosed and 1131.53±1554.80 pg/ml for healthy volunteers. Mean±SD Level of urine BLCA - 4 (ng/ml) for recurrent was 1.45± 0.26 ng/ml, for newly diagnosed was 1.30± 0.22 ng/ml and for healthy volunteers was 1.02±0.067 ng/ml. Urine level of these markers was significantly higher in recurrence group when compared with newly diagnosed and these levels decreased in normal volunteers which was statistically significance (P<0.001 for IL - 8, MMP - 9and BLCA - 4),also there was a significant increase in urine IL - 8 level according to grade(P=0.0002) and muscle invasion(P= 0.0009) as well as BLCA - 4 showed this significant increase in high grade(P=0.0001), and muscle invasion(P=0.0001),but no significant difference was found in the level of urine MMP - 9 with grade(P=0.23) and muscle invasion(P =0.069)In comparison, IL - 8 and MMP - 9 IHC staining of bladder tissue, showed low expression in cancerous tissue with no significant difference between cancer and normal urothelium(P=0.140 for IL - 8, P=0.265 for MMP - 9 ), and unrelated to grade, muscle invasion and recurrence.Significant increase in TLR - 2 and TLR - 4 expression in bladder cancer tissue than in normal urothelium (P=0.0001 for each), and according to grade and muscle invasion, TLR - 2 showed significant over expression in high grade than low grade (40.7%vs36.6%) with P=0.018, muscle invasion than non - muscle invasion (44.4%vs33.3%) with P value of 0.02, while TLR - 4 was none significantly correlated with grade andmuscle invasion. As well as, there was no correlation between these receptors with tumor recurrence.In regard to risk factors, Smoking, schistosomiasis and family history showed correlation with study marker in different manner as, IL - 8 was significantly highly expressed in smoking associated bladder cancer group, as well as patients with family history of bladder cancer showed high expression IL - 8, for Schistosoma associated TCC patients and UTI they demonstrated a statistically significant high expression of TLR - 2 p= (0.0001).From this study we conclude that urine IL - 8, MMP - 9and BLCA - 4 measured by ELISA showed specificity in diagnosis of bladder cancer, besides that, urine IL - 8, MMP - 9 and BLCA - 4 have a role in discrimination between newly diagnosed vs recurrent, with a significant association between urine IL - 8 with BLCA - 4 (P= 0.0001) and IL - 8 with MMP - 9 (P= 0.005) in patients with recurrent bladder cancer. Urine IL - 8 and BLCA - 4 concentration were statistically with significant increase in high grade than low grade and muscle invasion than non - muscle invasion, On the other hand, bladder cancer cells over express TLR - 2 and TLR - 4,while TLR - 2 showed correlation with high grade and muscle invasion,TLR4 did not show such correlation. Lastly, IL - 8 and MMP - 9 staining showed low expression in tumor tissue of different grades, stages and groups.

دور الايبشتاين بار فايرس كعامل محتمل لتقدم سرطان الدم اللمفاوي المزمن Molecular Characterization Of Metallo ? - Lactamase (MBL) Genes

اسم المؤلف: لمى عامر ياسر
اسم المشرف: عامر رشيد النجار داود سلمان داود
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Epstein Barr virus (EBV) is ubiquitous virus which infects the majority of the human population and is the causative agent of infectious monocleosis and a variety of B - cell tumors including Hodgkin lymphoma, Burkitt lymphoma, human immunodeficiency virus - associated lymphomas and post - transplant lymphoproliferative disorders , this virus expressed many protein and it is associated with a variety of B - cell tumors. Recently many studies have suggested a causal relationship between EBV and chronic lymphocytic leukemia (CLL). A prospective study of thirty samples of formalin - fixed, paraffin - embedded tissue of bone marrow aspirates samples and blood from newly diagnosis BCLL of 30 patients and our control included : 1) 20 bone marrow of patients who they have hematological disease other than leukemia as control. 2) Blood serum from healthy controls to study the level of IL - 10 and IL - 8. The present study conducted at Baghdad Teaching hospitals and the National Center of Hematology from September 2013 to Jun 2014. In this study we investigated the association between EBV and CLL. The detection of EBV encoded RNAs (EBER1,EBER2) by in situ hybridization and also latent membrane protein - 1 (LMP - 1) and EBV nuclear antigen - 2(EBNA2) by immunohistochemistry and detection for the level of Interleukin n (8 and 10) in the serum of CLL patients by ELISA. In situ hybridization study revealed that all the controls were negative for EBERs and 46.7% patients were found to be EBERs positive. There was a correlation between positive EBERs and tumors stage and also EBERs and IL10 and with LMP - 1 and EBNA - 2. Immuno - histochemical method was used to demonstrate the rate of (LMP - 1 and EBNA - 2) in CLL patients where a positive results of EBNA2 and LMP1were found in (43.3 % and 56.6s %), respectively in CLL patient group. All controls were negative with an exception of two patients were LMP1 positive. Enzyme linked immunosorbent assay test (ELISA) was used to detect the level of IL - 8 and IL - 10 in serum of newly diagnosed of CLL patients. Interleukin 8 was significantly higher in CLL cases group (33.1 pg/ml) compared to control group.On the other hand It was found that high increase in IL - 10 level ,in CLL patients when compared with controls. Conclusion : It can be concluded that there is a significant relationship between EBV and Chronic lymphocytic leukemia, mainly EBERs, also the association of significant increase in IL - 10 and IL - 8 with CLL.

مؤشرات جزيئية حول مقاومة الزوائف الزنجارية المرتبطة بخمج المجاري البولية للمضادات الحيوية Molecular Markers Of Antibiotics Resistance Of Pseudomonas Aeruginosa Associated With Urinary Tract Infections

اسم المؤلف: كريم عليوي حمادي سليمان
اسم المشرف: عامر رشيد النجار
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الزوائف الزنجارية : وهي بكتريا سالبة لصيغة الكرام والمنتشرة بشكل واسع في البيئة مثل التربة والمياه. وهذه البكتريا تتسبب في كثير من الالتهابات مثل التهاب المجاري البولية والتهاب الحروق وهي بكتريا انتهازية. وتشكل تهديد لحياة المصابين بالمجاري البولية وخاص | Pseudomonas aeruginosa is a Gram |( - ve) bacteria, widely presents in the environment such as soil, water, its incubation period (1 - 3) days, generation time 1 - 2 hrs. This bacteria causes many infections such as (UTI), and burn infections. It is an opportunistic pathogen, life threating for immune compromised patients such as diabetic patients. Pseudomonas aeruginosa is a nosocomial pathogen, and it is ranking the second among Gram ( - ve) hospitals acquiring pathogen. Its antibiotic resistance increased due to acquiring many antibiotics resistance genes. The spread of these genes among bacteria is via plasmids. Plasmid profiling of Ps. aeruginosa isolates by gel electrophoresis is a best technique for detection of plasmid content. Through this study, which was carried out in two main teaching hospitals, the diabetic center and private labs in Baghdad, during the period from January to October 2014. A total of (620) urine specimens were collected during (9) months. Urine specimens from inpatients were (420 / 620, 67.75%) and from out patients were (200 / 620, 32.25%). Urine specimens from Dialysis unit were (280 / 620, 45.1%) and from burn units were (140 / 620, 22.5%). The male represented (n = 334, 52.38%) while female were (n = 286, 46.20%). The positive cultures of urine samples obtained from hospitalized patients were (72 / 420, 17.1%) while for urine samples obtained from out patients (n = 40 / 200, 20%) were positive culture. A total of (112) positive culture out of (620) collected with (18.06%) percentage. A total of (30) bacterial isolates were tested by using disc diffusion method for susceptibility test forward to (15) antibiotics. Ps. aeruginosa isolates showed highest resistance to gentamicin (87.5%) while the lowest resistant toward meropenem, and imipenem with resistance percentage (16.7% and 8.0%) respectively.The occurrence of multi - drug resistance in (30) selected isolates were grouped as follows to (MDR) for those isolates which showed resistance to at least (3) antibiotics which was found to be (5 / 30, 6.6%). While (XDR) referred to those isolates which showed resistance to (4 - 5) antibiotics with (19 / 30, 63.3%). In related to (PDR) which referred to isolates that showed resistance to more than 5 with (6 / 30, 20%). The extracted plasmid DNA were resolved by gel electrophoresis for detection of plasmid content for (20) isolates including (10) isolates from inpatients, and (10) isolates from out patients. The selection of these isolates were grouped according to their antibiotic resistance pattern and the number of plasmids that they carried. The results showed that out of (20) there were (12 / 20, 60%) had no plasmid. While the remaining (8 / 20, 40%) had plasmids with different sizes and numbers. By using PCR technique the most common kinds of genes such as bla CTX - M, bla OXA, which encoded extended spectrum ? - lactamase (ESBLS) and those for metallo ? - lactamase such as bla IMP, were investigated with specific primers. Five isolates were selected depending on the numbers of plasmids which they carried and their resistance to antibiotics.

دراسة مؤشرات مناعية وبايوكيميائية مختارة لمرضى السكري النوع الثاني المصحوب وغير المصحوب باعتلال الكلى ذات الادرار قليل الزلال Study Of Selected Immunological And Biochemical Markers In Type 2 Diabetes With And Without Microalbuminuric Nephropathy

اسم المؤلف: علي ناصر محمد علي
اسم المشرف: عبد العظيم ياسين عبود البراك حازم عبد الرزاق عبد الوهاب
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Diabetic Nephropathy (DN) is a common complication of diabetic diseases occuring all over the world including Iraq. This type of microvascular complication of diabetes mellitus represents the most common reason of end stage renal disease (ESRD) in the world which considers the main reason for hemodialysis, kidney transplantation and death in developed countries. For this reason the assessment of some biomarkers as an early predicator before onset of microalbuminuria stage of diabetic nephropathy and the correlations between these biomarkers with microalbuminuria were carried out.This study was achieved at AL - Yarmouk Teaching Hospital and the Diabetes National Center /AL - Mustansiriyah University/Baghdad from January 2013 to September 2014. The study involved ninety individuals, twenty volunteers selected from the local community; apparently healthy (group I), 40 type 2 diabetics with normal urinary albumin to creatinine ratio (UACR) (<30 mg/g) (group II), and 30 type 2 diabetic patients with abnormal UACR (? 30 - 300 mg/g) (group III). Mean of diabetes duration (D.D.) in group II is about 4 years and in group III is about 8 years. The mean age for group I, II and III were 53, 55 and 58 years respectively. The concentration was measured of each microalbuminuria by turbidmeteric method, estimated glomerular filtration rate (eGFR) by using chronic kidney diseases - epidemiology equation, glycated heamoglobin (HbA1c) by using high performance liquid chromatography (HPLC), both fasting blood sugar (FBS) and creatinine (serum and urine) by using colorimeteric method, body weight by using body mass index (BMI) and all of IL - 18, IL - 12 IL - 4, IFN - ? and urinary vitamin binding protein (VDBP) by using ELISA method in three groups.The present study showed that there is inverse correlation between UACR and eGFR. The cause of this inverse correlation is that the decline in renal function of diabetics can be predicted accurately by using both UACR to show the increase in microalbuminuria while eGFR show a measure of the decrease in the ability of kidney for filtration.The difference of FBS mean between group I and II and group I and III was significant (P= 0.000 for both). The P - value between II and III groups was significant (P= 0.024). The difference of HbA1c mean between group I and II, group I and III and group II and III was significant (P=0. 000 for all). These results were expected as high HbA1c level is in consequence of high FBS. The difference of BMI mean between group I and II, group I and III and group II and III was not significant (P= 0.870, 0.885 and 0.968 respectively). Because the BMI levels were approximately constant in three groups. The difference of D.D. between group II and III was significant (P= 0.000).There was no significant correlation in group II between urinary albumin to creatinine ratio with each of diabetic duration, glycated haemoglobin, fasting blood sugar and body mass index (r=0.219 with P=0.244, r=0.039 with P=0.840, r=0.080 with P=0.673 and r= - 0.126 with P= 0.506 respectively); but there was positively significant correlation between urinary albumin to creatinine ratio with each diabetic duration, HbA1c and fasting blood sugar in group III (r=0.298 with P=0.043, r=0.869 with P=0.000 and r=0.518 with P=0.003 respectively) which may be due to the chronic nature of the disease in this group that require these risk factors to initiation; however, the correlation was non significant between UACR and BMI (r= - 0.127 with P=0.228) in group III.The difference of S.Cr. among I and II groups, I and III groups and II and III groups were not significant (P= 0.998, P= 0.331 and P= 0.145 respectively).The correlation was not significant in group II between serum creatinine with each of diabetic duration, glycated haemoglobin, fasting blood sugar and body mass index (r= - 0.140 with P=0.462, r= - 0.124 with P=0.515, r=0.168 with P=0.374 and r=0.007 with P= 0.969 respectively). Also, there was no significant correlation in group III between S. Cr. with each D.D., HbA1c, FBS and BMI (r=0.187 with P=0.077, r=0.109 with P=0.220 and r=0.175 with P=0.124 respectively). The reason of these results backs to that S. Cr. level is not increased as the podocytes remain intact in the diabetics with and without microalbuminuria.The difference of eGFR between group I and II was not significant (P= 0.303). The difference between group I and III and group II and III was significant (P= 0.001 and 0.010 respectively). The correlation was not significant in group II between eGFR with each of diabetic duration, glycated haemoglobin, fasting blood sugar and body mass index (r=0.121 with P=0.524, r= - 0.180 with P=0.341, r= - 0.310 with P=0.096 and r=0.021 with P= 0.911 respectively). Also, there was no a significant correlation in group III between eGFR with each diabetic duration, HbA1c, FBS and BMI (r= - 0.179 with P=0.07, r= - 0.188 with P=0.061, r= - 0.123 with P=0.388 and r= - 0.112 with P=0.557 respectively). The reason of these results back to that eGFR level is at the normal range in group II and slightly beneath the normal range in group III in consequence of the podocytes remain intact in the diabetics with and without microalbuminuria.The difference of urinary VDBP level between group I and II, group I and III and group II and III was significant (P= 0.000 for all). The correlation between urinary albumin to creatinine ratio levels and VDBP level (r=0.963) with P - value 0.000 which was positively significant in group III. The correlationbetween eGFR and VDBP was - 0.524 with P - value 0.003 which is inversely significant in group III. The reason of this inverse correlation may be similar to the reason of inverse correlation between eGFR and UACR, as the cubilin - megalin receptors are common receptors for albumin and vitamin D binding protein. Otherwise, the correlation between urinary VDBP and eGFR in the group I was a weak negative with non significant P - value (r= - 0.188, P=0. 428). The reason of this non significant correlation is that the cubilin - megalin receptors are not damaged by inflammatory process to elevate VDBP in urine; also the podocytes in glomeruli are intact from the damage by inflammatory process, so the eGFR was at the normal range in the control group.The correlation was a positive between HbA1c and VDBP levels in group II and group III (r=0.579, P=0. 001 and r=0.686, P=0.000 respectively). This positive correlation was explained on the basis that deterioration of sugar level control lead to increase the proinflammatory cytokines that damage cubilin - megalin receptors then VDBP increase in urine.The difference of serum IL - 18 level between group I and II, group I and III and group II and III was significant (P=0.000 for all).The correlation between urinary albumin to creatinine ratio and IL - 18 was 0.983 with P - value 0.000 which was positively significant in group III. This may back to damage the cubilin - megalin receptors by IL - 18 action that lead to increase of UACR in urine. In other words, the correlation between serum creatinine and serum IL - 18 in group III was not significant (r=0.041 with P= 0.830). This may back to that podocytes remain intact in this early stage of diabetic nephropathy. There is a significant positive correlation between serum IL - 18 levels and HbA1c levels in group II and group III (r=0.641, P=0.000 and r=0.721, P=0.000 respectively). These two positive correlations support the suggestion of choosing serum IL - 18 as an excellent biomarker for avoidance an early stage of the disease.The difference of IFN - ? levels between group I and group II, between group I and group III and between group II and group III were not significant as follows : (P=0.640, P=0.292 and P=0.522 respectively). The correlation between UACR and IFN - ? (r=0.047) with P - value 0.830 which was not significant in group III which means that IFN - ? is not a good biomarker for prediction of the microalbuminuria as an early stage of DN.The difference of IL - 12 level between group I and group II, between group I and group III and between group II and group III were not significant (0.884, 0.431 and 0.439) respectively. The correlation between UACR and IL - 12 (r=0.190) with P - value 0.314 which was not significant in group III.The difference of IL - 4 levels between group I and group II, between group I and group III and between group II and group III were not significant (0.943, 0.704 and 0.648 respectively). The correlation between UACR and IL - 4 (r=0.169) with P - value 0.371 which was not significant in group III.These results of IFN - ?, IL - 12 and IL - 4 might lead to conclude that both cytokines can’t be selected as a biomarker for an early detection of DN. Finally from the all presented data it can be concluded that IL - 18 and VDBP are considered more sensitive and more efficient than a classic diagnostic method (UACR and eGFR) for avoidance and detection the early stage of DN.

مميزات التحويرات المناعية للريسفراترول المستخلص من قشور العنب الاحمر على التهاب الكبد المحدث باستخدام ديكالاكتوزامين والذيفان المعوي نوع ب للمكورات العنقودية Immunmodulatory Properties Of Resveratrol Extracted From Skin Of Red Grape On Acute Liver Injury Induced By D - Galactoseamine And Staphylococcus Enterotoxin B

اسم المؤلف: صباح زيارة كاظم المالكي
اسم المشرف: عبد العظيم ياسين عبود البراك متزي نكاركاتي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعتبر اصابة الكبد الحاد احد الامراض ذو الاعراض السريرية التي تتصف بارتشاح الخلايا اللمفية الى الكبد وتجمع السوائل وارتفاع انزايمات الكبد مثل ناقل امين الاسبارتات Aspartate aminotransferase(AST) في مصل الدم. هنالك الكثير من الاسباب التي تؤدي الى حدوث ضرر | Acute Liver Injury is a vital clinical syndrome characterized by infiltration of lymphocytes in the liver, fluid accumulation, and elevation of liver enzymes such as Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the serum. There are many causes of liver injury, but in this particular study Staphylococcal Enterotoxin B (SEB) was used to induce acute liver injury in mice, it is previously known that (SEB) it act as superantigen that bind with T cell receptor variable region beta chain (VB8), and MHC II of Antigen Presenting Cells (APCs), which leads to activation of T - cells, and huge secretion of pro - inflammatory cytokines, all of these events cause an acute liver injury lead to liver failure, and death. In the last few decades the importance of some natural products appeared, in which these botanicals have an anti - inflammatory properties. Resveratrol is one of these botanicals with an anti - inflammatory effects, which was used as treatment in this study.This study was particularly intended to study the influence of Resveratrol on acute liver injury induced by Staphylococcus Enterotoxin B, lead to liver failure which includes estimation of aspartate aminotransferase levels (AST), histopathological analysis, immune cell counts of liver and spleen, in addition, study whether resveratrol has the ability to cause immunological changes on different immune cells that lead to suppress acute liver injury by using flowcytometry technique,these cells are inflammatory cells carrying CD3+ T cells, CD4+ T cells, CD8+ T cells, NK1.1+ T cells, CD44+ T cells, and suppressive cells such as Myeloid Derived Suppressor Cells (MDSCs), T regulatory cell (FOXP3), as anit - inflammatory markers. Furthermore evaluate the pro - inflammatory, and anti - inflammatory cytokines by using Bio - plex. Also to determine the molecular mechanism in which resveratrol can lead to induce changes in microRNAs (miRNAs) by microarray analysis. Finally validation (miRNAs) resulting from microarray analysis and genes of interest associated with these miRNAs by Real time polymearase chain reaction (RT - PCR).After sixteen hours blood samples were collected to determine AST levels in differents groups using Nanodrop, (Fisher - USA), after sixty hours animals sacrificing organs (liver, spleen) were collected afterward liver samples in 10% formalin were sent for histopathological study, liver immune cells were isolated for counts and molecular study (microarray analysis and quantitive (RT - PCR) total RNA was isolated from liver immune cells for microarray analysis then preparation of complementary Deoxyribonucleic acid (cDNA) by Reverse transcriptase PCR. Validation of the microarray analysis data was achieved by Real time PCR. Spleen immune cells were collected afterward for flowcytometric analysis of CD3+, CD4+, CD8+, NK1.1+, CD44+ T cells, MDSCs, and T regulatory cells using cell surface staining and intra cellular staining.This study showed that Resveratrol oppose the effect of SEB induced acute liver injury through decrease AST concentrations (P< 0.0001). Also Resveratrol 50mg/Kg body weight led to cause reduction in the size of the spleen, compared to SEB+ Vehicle group. Histopathology study reported that resveratrol led to decrease of hepatic necrosis up to 10% in comparison to vehicle group with 60% of hepatic necrosis and decrease in the inflammatory response represented by immune cells as in liver immune cell counts which showed a significant decrease (P< 0.014) after 50mg/ Kg body weight of Resveratrol treatment. Spleen immune cell counts result reported a significant decrease (P<0.013) in the total cells when Resveratrol was used as treatment compared to disease group. Regarding to Flowcytometric analysis, it was found that Resveratrol significantly decrease the absolute count of CD3+, CD4+, CD8+, NK1.1+, CD44+, Foxp3+ T cells in C57BL/6 mice (P< 0.0019, P< 0.001, P< 0.009, P< 0.002, P< 0.03, and P< 0.03 respectively). While MDSCs result reported significant increase with P< 0.01 in absolute cell counts after Resveratrol treatment. Depending on the Bio - plex data showed significant decrease in serum concentrations of inflammatory cytokines IL - 1?, IL - 1?, IL - 3, IL - 5, IL - 12p(40), IL - 12p(70), IL - 13, IFN?, MIP - 1?, MIP - 1?, KC and Rantes cytokines with significant P values (0.009, 0.004, 0.034, 0.004, 0.0009, 0.01, 0.0007, 0.009, 0.0037, 0.0001, 0.0035, 0.006 respectively), while anti - inflammatory cytokines IL - 6, IL - 10 and G - CSF c showed a significant increase in the serum concentration after Resveratrol treatment with a P values of, 0.012, 0.02 and 0.001 respectively. Microarray analysis results recognized 451 miRNAs with P< 0.05, according to fold change expression, 78 miRNAs have fold change greater than - 1.5 fold of expression in Resveratrol treatment group (downregulated), while 87 miRNAs have fold change greater than 1.5 fold of expression (upregulated). According to the ingenuity tools predicted target gene for some of these miRNAs by using miRNA.org database, the database showed that miR - 130a - 3p with - 2.28 fold expression have direct relation of binding with CSF1 gene, Real time PCR results confirmed the results obtained from microarray analysis, the result of miR - 130a - 3p showed a significant decrease of relative fold expression with P< 0.013, and Colony Stimulating Factor - 1 CSF1 (M - CSF) relative expression increased significantly after resveratrol treatment with P< 0.0001. From all of previous data, it can be concluded that Resveratrol can counteract acute liver injury induced by SEB, by decrease AST concentration. Resveratrol acts as an anti - inflammatory compound due to decrease of immune cell numbers, decrease of inflammatory markers, and increase of anti - inflammatory markers. miR - 130a - 3p with inflammatory properties downregulated after resveratrol treatment. Finally Resveratrol treatment increased relative fold expression of CSF1(M - CSF); gene which play a role in the MDSCs proliferation

دور الانترلوكين RA - 1 والسكليروستين والخلية التائية المستجيبة CD4 في مصل مرضى التهاب المفاصل الرثوي Role Of Serum IL - 1RA, Sclerostin And Effector T - Cell (CD4) In Rheumatoid Arthritis Patients

اسم المؤلف: سنن ثائر عبد الوهاب
اسم المشرف: حيدر صباح كاظم علاء الدين مظفر زبير
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: التهاب المفاصل الرثوي هو احد امراض المناعة الذاتية الاكثر شيوعا والذي يتميز بالتهاب المفاصل المزمن والذي يؤدي فيما بعد الى تدمير المفاصل.لا يزال مرض التهاب المفاصل الرثوي يعرف على انه سمة من التوسع في الغشاء الزليلي وارتشاح الخلايا الالتهابية اضافة الى | Rheumatoid arthritis (RA) is one of the most common systemic autoimmune diseases characterized by chronic joint inflammation and subsequent joint destruction. It is well known that RA is characterized by the expansion of the synovium and infiltration of the inflammatory cells coupled with destruction of adjacent articular cartilage and bone. This is strongly dependent on CD4 T cell. CD4 Cells stimulate monocytes, macrophages, synovial fibroblasts, and other cells to produce cytokines such as tumor necrosis factor - ? (TNF - ?), interleukin - 1 (IL - 1), IL - 6, IL - 15, IL - 17 and metalloproteinases that produce tissue damage. TNF is a major inflammatory cytokine contributing to the pathogenesis of RA, which provides rational for development of anti - TNF biological agents in the treatment of RA.Wnt pathway (a complex protein network) important in control of the bone formation through the regulation of osteoblast activity, and sclerostin is an important in the regulator of the Wnt pathway by blocking Wnt binding to its receptor and thereby inhibiting bone formation. Blockage of Wnt antagonists such as sclerostin will trigger repair or even healing of bone erosion.Recently have shown that IL - 1Ra has been given therapeutically in several experimental models of arthritis with weak effect in RA. This study planned to evaluate the frequencies of CD4+CD25+ Treg cells in Iraqi patients treated with RA under treatment with biological therapy (Etanercept). The level of serum sclerostin, serum level of IL - 1RA, and investigate the correlation between serum sclerostin and Treg expression. Correlate the level of serum sclerostin and Treg expression with disease activity by (CDAI or DAS28).This study was performed during the period from January 2016 to May 2016.The patients were attending the out patients' Clinic in Medical City/Baghdad Teaching hospital/Rheumatology Unit and the laboratory Enzyme Linked Immunosorbent Assay tests were done in Bio - technology center at the University of Al Nahrain, flow cytometery analysis was performed in the private laboratory (Al Rawabi Laboratory) at Yarmouk/Baghdad. Thirty patients and 30 apparently healthy control individuals were included in this study, Patients under treatment of etanercept.The diagnosis of RA patients has performed under the rheumatologist consultant at the consultation clinic of Baghdad Teaching Hospital of the medical city. Blood samples had taken from RA patients to measure Erythrocyte Sedimentation Rate, Complete Blood Picture, Rheumatoid Factor and High - Density Lipoprotein. Also, analyze the serum levels of Anti - Citrullinated Protein Antibodies and estimate the levels of sclerostin and IL - 1RAin patients and healthy individuals using Enzyme Linked Immunosorbent Assay test kits. CD4+CD25+ Treg cells had achieved by flow cytometery analysis.The results showed the reduction in Treg cells in patients (0.00264 ± 0.002) % under biological therapy than control group (0.026 ± 0.012) % with significant difference (p< 0.05). Also body mass index showed significant difference between patients (32.10 ± 5.81) kg/m2 and control group (28.84 ± 4.67) kg/m2 (p< 0.05). The results showed that sclerostin level higher in healthy (1.072 ± 0.59) ng/ml than patients (0.801 ± 0.28) ng/ml which showed significant difference (p<0.05). Furthermore IL - 1RA serum level was higher in healthy (0.979 ± 0.34) ng/L than patients (0.633 ± 0.35) ng/L with significant difference (p<0.05). Anti - Cyclic Citrullinated Peptide results showed non - significant difference between patients and healthy control. Treg cells is reduction in the patients with RA. Sclerostin and IL - 1RA levels are low in patients treated with etanercept.

دراسة جزيئية للاصابات بفايروس الحليمي البشري وفايروس سرطان الغدد اللبنية البشري في المريضات المجراة لهن عملية استئصال الرحم الكامل Molecular Study Of Human Papilloma Virus And Human Mammary Tumor Virus Infections Of Patients With Total Hysterectomy

اسم المؤلف: سري ظافر داود العزيز
اسم المشرف: سعد حسن محمد علي بسام شهاب احمد
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الاحياء المجهرية - الفيروسات
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Theoretically , the origin & mode of in - utero transmission of high risk Human PapillomaVirus (HR - HPV) types could be acquired hematogenously, by semen at fertilization or as asending infection in the genital tract. Viral Oncogenes E6 and E7 have ability to altered the Cyclin D1,p21 and p27 protein levels. Worldwide, Human Mammary Tumor Virus(HMTV) infection been described in hormonal responsive tissues.This research work is to study viruses in relaition to endometrial carcinoma in Iraqi patients.Materials and MethodsA retrospective study envolved seventy(70) cases (158 samples) of endometrial and cervical tissues collected from teaching laboratories in Medical City, Al - Yarmok Teaching Hospital and private laboratories related to the period from 2012 to 2014. Sections were made and subjected to chromogenic in - situ hybridization technique to detect the presence of High risk (HR) HPV 16/18 DNA and HMTV integrated DNA (provirus) and immunohistochemical technique to detect the presence of Cyclin D1,P21and P27.Results : The most commonly affected age group was ? 60 year 60.0% in malignant endometrial tumors, 40 - 49 years 36.0% in non - malignant endometrial tumors. Adenocarcinoma was the only histopathological type among endometrial cancer (100%) and the majority have well differentiated grade (90.0% ),and have (70%) T1b/IB stage.Hight risk HPV16/18 expression was detected 33.3% of malignant endometrial tumors, 20% in non - malignant endometrial tumors, andSUMMARY26.7% in control group. The higher rates of expression of HPV in cervical lesions was 40%.Most HPV16/18 infections revealed in both sites (cervix and endomertium) have Punctate DNA pattern.Cyclin D1 expression was mostly in 43.3% of malignant endometrial tumors and 33.3% was in cervical lesions. The significant correlation between Cyclin D1 expression and HR - HPV16/18 infection was reported only in malignant endometrial tumors groups. The highest P21 expression was 40.0% in malignant endometrial tumors and 44.0% in cervical lesions that reveals a significant association between p21 expression and HR - HPV16/18 infection. The highest rates of P27 expression were noticed among non - malignant endometrial tumors 24.0% and 32.0% in cervical lesions.While significant association of P27 expression with HR - HPV16/18 infection was only found in the cervical lesions among malignant endometrial tumors group.The distribution of integrated HMTV genome detected by Chromogenic in - situ hybridaztion (CISH) in the endometrial tissues was 16.7% in malignant endometrial tumor , 8% in non - malignant endometrial tumors, and 13.3% in the control tissues group while in the cervical lesions HMTV was detected in 13.3%. Significant correlations were found between HMTV infection and Cyclin D1 expression in the cervical lesions among malignant endometrial tumors group and p21 expression in the malignant endometrial tumors.ConclusionsHR - HPV16/18 may be associated with initiation of endometrial carcinogenesis events as well as play a role in the progression of such malignant tumors in addition ,these viruses could ascendingly be transmitted from lower part(cervix) to the upper part of the genital tractSUMMARY(endometrium) in some way or other.Cyclin D1 ,P21,and p27 could have sharing in early events of tumorgenesis in endometrial carcinoma and a significant correlations of Cyclin D1 ,p21& p27 expressions with HPV infection was observed among study group.Althought a relating low rates of HMTV infection were detected among different endometrial as well as cervical lesion in this Iraqi study,it might mark or shade alight in the way for further researches in this field to exposure more aspects of this newly studied virus among other hormonal dependent malignancy

تقدير مستويات السايتوكينات (الحركيات الخلوية) المولدة للالتهاب والمضادة للالتهاب لدى مرضى فصال العظام في الركبة قبل وبعد الحقن بالبلازما الغنية بالصفيحات الدموية Estimation Of Pro - Inflammatory And Anti - Inflammatory Cytokines In Patients With Knee Osteoarthrosis Before And After Injection With Platelets - Rich Plasma (Prp)

اسم المؤلف: حسنين خضير عبد العباس
اسم المشرف: عبد العظيم ياسين عبود البراك سامر محمد رضا عنون زيد وجيه رؤوف الشهواني
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: دكتوراه
الجامعة: الجامعة المستنصرية
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: التهاب العظام والمفاصل Osteoarthrosis)) او فصال العظام او ما يعرف بالاسم الشائع السوفان هو مرض يحدث في غضروف المفصل الذي يعمل على عدم احتكاك عظام المفصل ,مما يؤدي الى تقليل هذه الحماية ضد الاحتكاك فتصبح حركة المفصل بها خشونة ومصحوبة بالالام عند استخدام ا | Osteoarthrosis (OA) are defined as a progressive architecture destruction of the joints compared to slow healing of these joints which leads to reduce protection against degeneration and the movement of the joint is associated with by the roughness and accompanied by pain when using the joint. Often this disease affect the knee joint, it may affect any other joint in the body, especially those that carry weights such as leg hinges the pelvis, elbow and spine. The aim of this study is to evaluate the efficacy of platelets - rich plasma injection in osteoarthritis knee and the estimation of the biological and immunological markers associated with the treatment. This study involved 50 patients suffering from inflammation of the knee joint under supervision of speiclist of orthopedic ,most of these patients attended Al - Shaheed Firooz hospital in wasit Governorate and specialty private clinics of orthopedic and Rheumatology in the district during the period from April 2015 until October 2015.The age of patients was about 35 - 65 years; 31 females and 19 males with 25 healthy matching group. All patients were injected into the knee joint by a specialist physician with two injections during two months with platelets - rich plasma (PRP)after its preparation from the same patient's blood in sterile conditions. This was done after the signing of the patient or one of his relatives on the written consent to conduct the injection process after explaining and clarifying the principle of injection and the purpose. The level of pain of patients group was measured by Visual Analogue Scale (VAS). The enzyme linked immunnosorbant assay ELISA method to determine the level of some of cytokines in serum of patients group (interleukin - 1beta, tumor necrosis factor - alpha,IL - 10,IL - 8 and Transforming growth factor - B1) in addition to measuring the concentration of C - Reactive protein (CRP).The rate of Erythrocyte Sedimentation Rate (ESR) was also estimated. All were done to all patients groups before and after injections with PRP in addition to healthy group. Statistical analysis showed no significant differences between males and females (54.5±1.2 males, 53.2±2.1 females). The study showed significant decrease in the mean of the Visual Analogue Scale (VAS) of patients before and after two months of injections with (PRP) 8.46 ± 0.104, 5.98 ± 0.129, , respectively, with highly significant differences (P=000.0) , also the study showed that there was no significant differences in VAS between age groups (30?s, 40?s, 50?s , 60?s) before and after injections with PRP (7.5,8.0 ,8.38 ,9.05), (5.0,5.55,5.69,6.7) respectively. The study also showed a difference in the mean for inflammatory marker C. Reactive protein concentration before and after injections with PRP 7.156± 0.328 µg/ml, 5.384± 0.196 respectively, in comparison with healthy group with highly significant differences (P=0.000).The study also showed a difference in the mean of ESR before and after injections with PRP (35.66± 0.879 mm/1hr, 23.7±0.856) respectively, with in comparison with healthy group highly significant differences (P=0.000).The mean of Interleukin 1 - Beta(IL - 1?) was decline after injections with PRP from 13.220±0.295, pg/ml to 9.622 ± 0.273 pg/ml in comparison with healthy group with highly significant differences (P=0.000). Also a decline in the mean of Tumor necrosis factor - alpha (TNF - ?) after injections with PRP from 62.384±0.927 pg/ml to 55.36 ± 1.121 pg/ml in comparison with healthy group with highly significant differences (P=0.000). The study also demonstrates a decrease in the mean of Interleukin - 8 (IL - 8) before and after injections with PRP (41.092±0.808 pg/ml, 35.93 ± 0.813pg/ml) respectively in comparison with healthy group with highly significant differences (P=0.000). An increase in the mean of Interleukin - 10(IL - 10) after injections with PRP from 5.108±0.291 pg/ml to 6.734±0.330pg/ml, in comparison with healthy group with highly significant differences (P=0.000). The final parameter in this study was demonstrated an increase in the mean of Transforming growth factor - ?1 (TGF - ?1) before and after injections with PRP (111.544±6.960, 149.212±7.540pg/ml) respectively in comparison with healthy group with highly significant differences (P=0.000). Association was obtained between VAS score and C. RP as well as ESR after treatment. PRP treatment also has an impact on increasing the level of anti - inflammatory IL - 10 and TGF - ?1 on one side and the decreasing level of pro - inflammatory IL - 1?, TNF - ?,IL - 8 (catabolic marker) on the other side these results suggest the inhibition of catabolic process demonstrated by reducing of VAS scores and the efficacy of effectiveness plasma rich platelets (PRP) treatment of osteoarthrosis.

اثر عوامل البيئة الاجتماعية على سلوك سيطرة وزن المراهقين في المدارس الثانوية في مدينة بغداد Impact of Socio - Environmental Factors Upon Adolescents' Weight Control Behaviors In Secondary Schools At Baghdad City

اسم المؤلف: بثينة بشير صالح
اسم المشرف: اقبال غانم علي معلة
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: التمريض
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: دراسة وصفية(مقطعية) اجريت في جانبي الكرخ والرصافة لمعرفة اثر عوامل البيئة الاجتماعية على سلوك سيطرة وزن المراهقين في المدارس الثانوية في مدينة بغداد للفترة من 20 من شهر نيسان لعام 2013 الى نهاية تشرين الاول لعام 2014.تهدف هذه الدراسة للتعرف على عوامل ال | Overweight and obesity are one of the biggest threats for public health, both in children and adolescents. Fair enough, a lot of attention is paid towards this threat. However, hardly any attention is paid to weight loss behavior in normal weight children and adolescents. Teenagers who consider themselves as too fat who were negative body image a high risk for unnecessary weight loss behavior. A Cross - Sectional Descriptive study was conducted on impact of socio - environmental factors upon adolescents' weight control behaviors in secondary schools at both sides Al - Karkh and Al - Risafa sectors of Baghdad city. The study period started from 20th of April 2013 to the end of October 2014. The study aimed to find out the relationship between weight control, and socio - environmental factors and adolescents' demographic data (age, gender, Body Mass Index, and socio - economic status), and find out the impact of socio - environmental factors upon adolescents' weight control behaviors. A non - probability (purposive sample) of secondary adolescent schools , while 1254 adolescents' students were chosen randomly from that schools. The study instruments consist of four parts. The first part concerned with adolescents' students and their parents? socio - demographic data; the second part is about adolescents' students eating patterns and their meals list at home. The second part is divided into six sections. The 1 section consists of 28 items : the adolescents' students eating patterns and meals list at home, section 2 and 3 contains 16 items : for eating the snacks and fast food, section 4 is composed of 12 items : which are about adolescents' students eating time in schools with peers, section 5 has 12 items : related to the reasons of skipping meals, and section 6 consists of 6 items : about adolescents' lifestyle. The third part is about the physical activities and dieting programs, it consists of 7 items. The fourth part 10 items are related to the adolescents' weight control behaviors. Test - retest determined the reliability of the study instrument which was r = 0.90. A descriptive statistical analysis (frequencies and percentages) and inferential statistical analysis, and (chi - square) were used. The result of the study sample indicated that more than two fourth of the Body Mass Index was almost equal in under or normal weight while the another half were overweight and obese, and the sample's family socio - economic status was in high or low level status. The study indicated most of the adolescents' took breakfast at home, eating snacks, reasons of skipping breakfast meal, and their lifestyle had a highly significant association with their gender and that indicate no differentiate between their gender eat what they want at any time. The results of the study reflected the adolescents' students eating lunch and dinner at home, and reasons of skipping breakfast meal had no significant association with their ages. The adolescents' students favorite to eat snacks and fast food at home and it's had a highly significant association with their Body Mass Index. Also there is a highly significant associated for the study sample socio - environmental factors with their socio - economic status. The results of the study reflect that is a highly significant association between eating habits and their total weight control behavior methods. The study recommended the Ministry of Health need to activate the nutritional program strategies for weight management within school health services, and need to increase establishment other especial centers for managing adolescents from risk for overweight and obesity like as Obesity Research and Therapy Unit in AL - Kindy College of Medicine and Nutrition Research Institute. I suggest a schedule as a guideline for healthy nutritious for weight control and achieve daily physical activity Finally Ministry of Education need to involved teachers in that strategies and training them in relation to these programs.

فاعليه تطبيق الممرضين للممارسات القياسية على العناية بالاطفال حديثي الولادة المصابين بمتلازمة كرب التنفس في وحده العناية بالاطفال حديثي الولادة في مستشفيات بغداد للاطفال التعليمية Effectiveness of Nurses Application of Standard Practices On Care of Newborn With Respiratory Distress Syndrome In Neonatal Care Unit At Children And Maternity Teaching Hospitals

اسم المؤلف: محمد عزيز حسن
اسم المشرف: اقبال غانم علي معلة
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: التمريض
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت دراسة شبه تجريبية في مستشفيات بغداد للاطفال التعليمية للفترة من 28 من كانون الثاني الى الاول من ايلول لسنة 2014 لتقييم فاعلية تطبيق الممارسات القياسية للممرضين والذين يتعاملون مع الاطفال حديثي الولادة المصابين بمتلازمة كرب التنفستم تقييم الحاجة من | A quasi experimental(interventional) study was carried out at Baghdad pediatric teaching hospitals in Baghdad from the 28th of January to the 1st of September 2014 to assess the effectiveness of the application of standardized practices to nurses dealing with neonate with respiratory distress syndrome. Assessment of needs was done to evaluate the nurses practices towards neonates with respiratory distress syndrome in neonatal care unit(NCU) by using a special format which includes multiples questions related to nurses knowledge and practices for 10 nurses works at the private Nursing home.The result of the assessment revealed that the nurses have poor knowledge and practices towards neonates with RDS. A pretest test was performed before the application of the program for 35 nurses, three of them was out of the study sample.Observation their practices based on the standardized items which was prepared by the researcher and extensive review of the literature. A non - probability (purposive) sample of 32 nurses who work in the neonate intensive wards was chosen to be involved in study sample, and an educational program was designed based on the results and basic nursing guidelines related to care for neonate with respiratory distress syndrome, it consists of two parts : the first part consists of demographic data, and the second part consists of an observational checklist format related to the nurses practices in care of neonate with respiratory distress syndrome. The questionnaire was used to observe the nurses practices in the pre - test applied before the program started , post - test 1 immediately after the application of the program, post test 2 after 1 month from the post test 1,and a post 3 after 2 months from the second post test. The reliability of the questionnaire was conducted through a pilot study and validity through a panel of experts. The data were analyzed through the application of a descriptive statistics frequencies ,percentages ,and application of inferential statistical procedures which include Pearson correlation coefficient and paired test. The finding of the study revealed that the nurses practices towards neonates with respiratory distress syndrome were improved after the implementation of the program in most of the items of the post test 1 ,2,and 3 of the program, and there is a significant association between nurses' practices and their level of education in most of the program items, There was also a significant association between nurses practices and years of their experiences. The study recommended increasing knowledge and practices of the nurses working in the neonatal care unit through regular training courses, in addition to increasing the number of graduated nurses from the College of Nursing in this critical unit.

تاثير البرنامج التثقيفي التمريضي على معارف وممارسات الملاك التمريضي ازاء التاهيل القلبي لمرضى النوبة القلبية The Effectiveness of Nursing Educational Program On Nurses Knowledge And Practices Toward Cardiac Rehabilitation For Patients With Heart Attack

اسم المؤلف: احمد عجلان علاوي ناصر
اسم المشرف: حكيمة شاكر حسن
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: التمريض
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية التمريض
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت دراسة شبه تجريبية في مستشفى الشيخ زايد ومستشفى الصدر العام ومستشفى الكرخ العام ومستشفى الكرامة ومدينة الامامين الكاظمين الطبية ومستشفى بغداد التعليمي للفترة من الاول من ايلول2013 الى الاول من ايلول2014 تهدف الدراسة الى تقويم فاعلية البرنامج ال | A quasi - experimental design study was carried out at the AL - Sheikh Zayed hospital; AL - Sader; Al - Karkh ;AL - Karama ;Imameinkadhimein medical city and Baghdad Teaching hospital during the period from 1st September 2013 to 1st September 2014. The objective of the present study is to evaluate the effectiveness of nursing education program on the nurses knowledge and practice toward cardiac rehabilitation phase one for patients with heart attackThe program and instrument were constructed and developed by the researcher for the purpose of the study A random sample composed of (80) nurses was divided into two groups , the experimental group consisted of (40) nurses exposed to the nursing educational program and control group consisted of (40) nurses were not exposed to the program.Reliability of instrument was determined through the use of test and retest for the knowledge test and inter - observation for practice and the instrument validity was determined through a panel of experts. The instrument to measure the effectiveness of nursing educational program on nurses knowledge and practice included (30) items concerning the nurses knowledge and 58 items included nurses practice nurses practices toward cardiac rehabilitation phase one for patients with heart attack.The analysis of data was performed through the application of description statistic(Frequencies, Percents, and Cumulative Percentages , Mean of Score , Standard Deviation , Relative Sufficiency ) and Inferential statistical (Contingency Coefficients , Chi - Square test , Fisher to present the differences between the experimental and control groups. The results of the study shows that the nursing educational program regarding nurses knowledge toward cardiac rehabilitation program phase one is effective. They also shows that there is a good improvement with highly statistically significant differences between pre - post tests of experimental group in overall domains related to nurses practice in items of health assessment heart, assessment chest pain, cardiogenic shock, daily activity living and health education. The study concluded that the nurses working in coronary care unit have deficient knowledge and practices toward cardiac rehabilitation phase one for patient with heart attack. The study also confirms that the instruction oriented program on nurses in the experimental group is successful. The study recommended that the nurses staff can be encouraged and having motivation for being participated in the special training programs and conference to fulfill the nurses needs concerning defects and limitations ed in their practice toward cardiac rehabilitation phase one for patient with heart attack.

البعد الجمالي في التكوينات الابداعية للخط العربي Aesthetic Dimension In Linear Formations Creative Calligraphy

اسم المؤلف: كريم سالم الساعدي
اسم المشرف: جواد عبد الكاظم فرحان الزيدي
الموضوع العام: الفنون الجميلة
السنة: 2014
الموضوع الدقيق: الخط والزخرفة
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية الفنون الجميلة - قسم الخط العربي والزخرفة
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعد مسالة الابداع والابتكار واحدة من اهم المسائل التي تشغل الانسانية في شتى مجالات المعارف والعلوم والفنون، فالابداع سمة العصر الحديث والطريق نحو النمو والرقي الحضاري، ولا يستثنى اي حقل معرفي او جمالي من الانشغال في قضية الابداع والابتكار فهما وسيلة التا | The issue of creativity and innovation is one of the most important issues of concern to humanity in various fields, Creativity characteristic of the times and the road towards progress and prosperity.To Aisttny any field of cognitive or aesthetic preoccupation with this issue, they are the means of meditation deep problems in order to develop solutions to the original and suitable.In Arabic calligraphy, which still indicates many of the questions and give a lot of fields of research is the study of dimensions of creativity is very important to deepen in the region to focus on the aesthetic and artistic objectives.When not studied this issue extensively, has directed the researcher to study through the four seasons, wondering in his first season for dimensional aesthetic that is available by formations linear, and attributes its transformation into a formality creative new leaves the context of traditional and maintains the rules discreet Arabic calligraphy.In the theoretical framework have addressed researcher in three sections to the concept of linear creative formations, as well as the characteristics of the formal and aesthetic and semantic configurable linear, and the effectiveness of Marja receive text language as a springboard aesthetic creative founder of the degree zero aesthetic in modern linear configuration.This included the third chapter action research to analyze the models selected sample and the approval of the orientations of the search, the according to a set of pillars appropriate to achieve the objectives of the research, and seal search a bid for the results showed the contribution of infrastructure design and processing of the contents of the text, and overlapping techniques races other technical in the incorporation of the dimensions of the aesthetic and creative in the configuration linear , as demonstrated by the conclusions of the possibility of achieving the objectives set for the search through the system prepared by the researcher and down to develop a set of recommendations and proposals.

ما بعد الحداثة وانعكاساتها في سينوغرافيا العرض المسرحي العراقي Postmodernism And Anekasthe In Scenography Supply Iraqi The

اسم المؤلف: فيصل علي شرين الدوسكي
اسم المشرف: قاسم مؤنس عزيز
الموضوع العام: الفنون الجميلة
السنة: 2014
الموضوع الدقيق: الفنون المسرحية - المنظر المسرحي
الدرجة: دكتوراه
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: يعد فن المسرح من الظواهر الحضارية الانسانية، اذ يوصف بالتطور على مستوى وجود الانسان بمستواة التاريخي، ويعد قديما على مستوى ظهور الحضارات الكبرى كما هو حال حضارة وادي الرافدين، ووادي النيل، والحضارة الاغريقية...الخ.ويمكن لقاريء تاريخ المسرح ان يلتمس ت | The art of the theater phenomena of human civilization , as described evolution at the level of the existence of the historical rights to its level , and is out of date at the level of the emergence of great civilizations , as is the case with the civilization of Mesopotamia and the Nile Valley and the Greek civilization... etc..A reader theater history to seek the development of the theater with Greek civilization and Romania to disclose material and references and institutions with beginnings and growth , which differed in which researchers , but what can we adopt in this thesis is what constitutes the structure PRESENTATION formal and dynamic game play as the development of methods Manifesting dazzling accompanied this growth of civilization , which can be described as the growth of tissue adopted all the knowledge available in the neighborhoods of the investment game play , including the science of optics and physical blocks and the lighting and colors and different... etc. Alaihamat of Science neighboring possible to utilize them in a product of game play.This as well as the evolution and transformation of aesthetically pleasing as a result of shifts in the structure of consciousness itself , and appointed to the nature of beauty and the beautiful , including changes to the historical level of movements and technical approaches , which as the variable information on the level of art history , or philosophy of art history , and is the idea of post - modernism , and their productions of the most important aspects of development and transformation in the taste of the Assembly, which swept the arts and literature , and all the creative structures of human civilization , including the art of theater that has been affected by and produced what we might call postmodern theater , which skips steps intellectually and technically.One manifestation of the modern theater transformation broad scenography theater , which was adopted approaches and trends of modernity , starting from Impressionist and passing Baltkaaabah and symbolic and Dadaism and the end Balsraalah , but that theater modernism influenced by the art of assembly and installation , which is one of the arts postmodern At the time of modernity itself and it is normal because the interval between modernity and Beyond separator default, can not be entirely watershed where things are a lot of overlap.The postmodern art , particularly theater , has achieved the outcomes of the task can be half to proceed with actors , which will reveal the institutions of post - modernism itself , and these outcomes with regard to the art of body art of the earth , and Video, and digital art , and these trends that form the structure of post - modernism , and found its place fertile in the art of theater in its system design.The Iraqi theater of theaters in bold and call variables which surprised theaters in the neighboring countries and the manifestations of this is what we find in the daring design creations , especially theater scenography of postmodernism.The researcher found that this trend did not take his scientific position and described dimension for analysis and exploration and drilling flour , despite the importance of the subject and seriousness because a shift in the overall environment for viewing theater , directed towards the form that builds scenography theater as an important center and active in PRESENTATION , which shows the importance of this research and the need for him as well as the goals and limitations cited by the researcher in the first chapter of this thesis and after the completion of the researcher to this chapter represented a systematic framework for the search , and then the definition of terms , the frame of mind of knowledge ( theory) is built on the following according to the detective.To enable the researcher of the mechanism of scientific research the exact terms founded and bases to reveal the secrets of this organization and to realize the verdicts Almazmrh and which was governed by a set of structures and cultural patterns , social, economic and even psychological linked Bmarjaaat doctrinal through First research of the second quarter , which was under the title ( the philosophy of modernity onwards ) of this section has been detected philosophy of modernity and their references and their origins and transformations to the postmodern.The second section devoted to ( artistic forms of art postmodern ) because the subject of modernity and beyond is the fabric represents all aspects of civilization kinds Mstdeih inclusiveness and interaction of all aspects of culture change that was philosophically and politically or scientifically or technically , and calls for change and openness to the new.The third section ( Alcinogravea and a mechanism to engage in postmodern theater ) reveals that the correlation between design and architectural Alcinogravea stage and the mechanism of performance and technology that have subscribed to a set of elements and mechanisms that shape the visual presentation of the playwright. Reading is the new scenography in postmodern theater allows for the recipient that explains the artwork in his own way , but re - formed , and according to his reading on what he sees and diversity of stylistic trends of the scenography depending on the variety of trends and styles in the era of post - modernism.After he finished his research researcher kits through detective theoretical , intellectual and technical moved to the third quarter , which represents action research as beginning with his community and his research samples and method , and the method of sampling Mentahja intentionality of the total samples of the title in question and the justification for the selection of samples.Finally, it was the fourth quarter , representing the results and conclusions reached by scientific research which has important consequences on the theoretical level analytical and exploratory and finally the level of future default.The researcher presented at the end of his research recommendations was for supplements that include interviews and research provided by the professors thought and literature, theater and the creators of the design at the College of Fine Arts Mtfdilan thankfully they are both professors Prof. Dr. Fadil (Sami Abdul - Hamid ) , Dr Fadil ( Fadel Khalil ) Dr Fadil ( Salah reeds ) , Dr Fadil ( Abbas Ali Jaafar ) Dr Fadil ( star Haider ) , Dr Fadil ( Hussein Altk ) , Dr Fadil ( Mohammed Abdel - Rahman al - Jubouri ) , Dr Fadil ( Aqeel Muslim).Finally, like the researcher a statement that art ( scenography ) postmodernism in the Iraqi theater is an art recently has been associated with the renaissance of the theater , after the arrival of creative artists from Europe , including the artist ( Kadhim Haydar ) and artist (Sami Abdel Hamid) and artist (Ibrahim Jalal ) and artist ( Fadel Khalil ) and artist ( Salah reeds ), which is an inexact art and composite difficult to interact with it and achieve results , making its employees do not complete the fingers stop per numbering they Mtfaalon in the level of their offspring quantitative and qualitative , and many of the constraints facing the working art Alcingravea , including constraints and objective thought , because theater postmodern disregards the form and terms of reference or foundations or private art techniques , each work has its style and its terms of reference and ideas that are different from the other work

جماليات توظيف برامجيات الحاسوب في سينوغرافيا العرض المسرحي The Aesthetics of Employing Computer Softwares In The Scenography of Theatrical Show

اسم المؤلف: راوية جبار حسن
اسم المشرف: محمد عبد الرحمن الجبوري
الموضوع العام: الفنون الجميلة
السنة: 2014
الموضوع الدقيق: الفنون المسرحية - تقنيات
الدرجة: دكتوراه
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: ان المسرح يعد حصيلة لتكامل النص مع الاداء الصوتي والحركي للممثلين ومدى انصهارهم مع المنظر والاضاءة والازياء، وهنا تظهر امكانية استخدام برامج الحاسوب في جزء من المنظر والمؤثرات الصوتية والضوئية وباستخدام تكنولوجيا العرض هذه مع بعض برامج الحاسوب مثل ( 3D G | The theater is considered as a product of text integration with voice and kinetic expression of the actors and their interaction with the scenery, lighting and costumes. Hence, we can find a possibility of using a computer in a part of the scene, sound and lightening effects. Using display technology by some computer programs such as (3D Graphics) and (Virtual Reality) can configure the sense of depth and different views that commensurate with the desired show. It is also characterized by dynamic capabilities which are not available in the traditional decor based methods. For example, dynamics allow making a change on the display elements with taking advantage of other video presentations to be an integral part of the background. The actual or real effects are to invest the non - final maximum energies for the PC in the creation of artwork tools and symbols, reproducing voice and image so that it its impact on viewers (sometimes) would exceeds the reality and beyond sometimes. The actual effectsoffer its tools to the computer user; would make it dive into an experience that is so close to reality. So the researcher has divided her research into four chapters : Chapter I - Research methodological framework : it includes the research problem, its importance, the need to it, its goals and limits. It ends with defining the following terms : (beauty, employment, software, computer, theatricalscene) Chapter II - it contains a theoretical framework for the research and previous studies, including four sections : First : the aesthetics of modern experiments in the formation of the scene. Second : technology and experimental trends.Third : the aesthetics of design by the computer (Digital Arts). Fourth : lighting devices used in modern theater. Finally, this chapter shows the indications that the theoretical framework ended up with.Chapter III : it includes the research procedures which the whole research was consisted of. It is limited to the Iraqi and Arabic theatrical performances. The samples of the research on the other hand were deliberately chosen by the researcher and for the following rationales : 1. The samples represent the research problem, its importance and its objectives. 2. The extent of disparity between the theatrical directors which the researcher has highlighted their scenes on a play that was embodied by their theatrical shows. 3. Archival sources of theater shows provide the sample of the research. Regarding the research methodology, the researcher has adopted the analytical approach in the presentation of theoretical framework, also adopted the descriptive approach in the presentation of samples brought by the whole research.As for the research tool, the researcher relied on the indicators that resulted from the theoretical framework.The research samples are : 1. Adding Machine directed by (Ronald Wells)2. theatrical play (Play) directed by (Lance Jarafa)3. The use of technology in the play of (Othello) directed by (Salah Qasab).Chapter IV has included research results and conclusions, then the list of resources and supplements. Finally, it ends with an English abstract.

نظريات الاتصال الحديثة واسقاطاتها الفكرية على المنتج الصناعي The Modern Communication Heories And Their Intellectual Impact On The Industrial Product

اسم المؤلف: جاسم احمد زيدان
اسم المشرف: شيماء عبد الجبار حميد العبيدي
الموضوع العام: الفنون الجميلة
السنة: 2014
الموضوع الدقيق: التصميم الصناعي
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية الفنون الجميلة - قسم التصميم
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Industrial design is regarded as an intellectual and cognitive product that is developed with accordance to the analytical awareness of man interpreting accordingly the external existence with the means of senses which human and other creature have. The senses are the window overlooking the external world and the environment. The form the beginning of mediation and observance and concentration and the formation of depictions which work according to the innovative imagining.Therefore the industrial design is regarded as one of the important pivots of the fine arts. These pivots revolve around the bases of how to convey meaning or the design of the idea to the users or the receivers in the clarity with hindrance to the understanding.The language of visual communication which scientific ad practical bases are formed according to the modern theories of communication. It is the language of modern communication of signs and relations are connected together. The modern theories of communication have offered developed system of communication to the user. But these face the problem of awareness and culture in the confrontation of the developed industrial products (multi - purpose digital devices) as means of communication in finding utilities.Upon the above, the researcher preferred to found the problem of his study through revealing the reflections which are formedby the modern theories of communication on the industrial product of the electronic device (Smart TV, Smart Camera, interactive board, Tablet PC, Smart phone).The study aims at the following : 1 - Investigating the modern theories of communication ad their intellectual impacts on the industrial product.2 - Analysis of sample of modern industrial products to know the effect the modern theories of communication in the development of product.In order to verify these objectives, the researcher founded a theoretical framework that tackles the philosophical backdrops to knowledge and communication and put the following (3) inquiries : First inquiry : The relationship between sensual visual realization and communication.Second inquiry : the modern theories of communication and their application fields.Third inquiry : the aesthetic thinking and its relations to the theories of communication and their impact on the industrial product.The researcher comes up with a number of indications which resulted from the theatrical framework depending I the design of the instrument which is the content analysis form of the industrial product specified in the sample.In order to determine the modern theories of communication that could be concord with the samples of the study, the researcher made a survey of the opinions of the experts in these theories. They referred to him to the theories of (McLuhan - Diffusion and innovation - selective effect - developmental technology).The research community was confined in the products of Samsung ad Sony institutions. The researcher chose a sample of (5) products after consulting the experts in the field of industrial design. The, these samples were analyzed according to the analysis form prepared for that purpose, which was subjected to the validity coefficient test by exposing them to the group of experts.Based on the analysis conducted for the sample, the researcher came up with a number of findings : 1) The structure of the sample was characterized by an apparent functional value and utilization which the user can touch and enjoy in their aesthetic function.2) The sample was characterized by digital products with aesthetic value especially in relation to the outside form of these products which contain attractive points emerging from the utilizing features for every type. This created a form of power in the taste.3) There is a clear reflection of the modern theories of communication on the functions of the industrial productsof sample in the functional and utilizing ad aesthetic aspects.The most important findings are the following : Upon these conclusions the researcher made a number of recommendations which are :

نظرية الحل الابتكاري TRIZ وانعكاساتها في التصميم الصناعي Theory of Inventive Solution (TRIZ) And Their Repercussions In Industrial Design

اسم المؤلف: محمد علي حسين القيسي
اسم المشرف: قدوري عراك صكر
الموضوع العام: الفنون الجميلة
السنة: 2014
الموضوع الدقيق: التصميم الصناعي
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية الفنون الجميلة - قسم التصميم
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The importance of the research is the importance of the theory of (TRIZ), which are based on the scientific method resulting from the analysis of the content of more than two million patents, founder of (TRIZ) was Genrich Altshuller, it assumed that the principles of general creative form the basis of the output of creative and that these principles can be identified and transferred to others to make the innovation process more amenable to learn. It recognize as the most important theory of the task, as adopted in more than (50) major international companies, including Company (Boeing for the aircraft industry and Toyota Motor).To summarize the research's problem, there is no publication of TRIZ theory concerning industrial design, the goal of the research is to characterize and employ a matrix of contradictions for the purpose of contradictions matrix Created especially to industrial design. The search Limit to traditional TRIZ theory (1973), which includes a matrix of contradictions, which contain in its composition, the forty principles and the 39 engineering standards as objectives limits, the research contain its theoretical framework of four sections, the first section dealt with the creativity and its theatrical concepts. This has been confirmed that the creativity and innovation cannot be taught or trained or acquisition, as well as the concept of creativity after the first quarter of the last century which showed that creativity could be educated and transformed.The second part of the research explain TRIZ theory and nine of their instruments, The tool matrix contradictions have been allotted for the Study of particular axis as the basis for the study.The third section has dealt with the contradictions and i matrix Included on the study of the concept of contradictions besides reviewed the (39) engineering standards and forty principles, the fourth section studied eight previous TRIZ's studies.The most important findings of the study was achieved the contradictions matrix model of industrial design, which Includes on (20) engineering standards and (40) principle. These principles characterized of the examples used to explain them was new which is taken from the field of industrial design and pro

التمثلات الفلسفية للحداثة في خطاب السينماتوغراف Representations Philosophy of Modernity In The Structure of Assets Cinematograph Speech

اسم المؤلف: ماجد عبود الربيعي
اسم المشرف: محمود اكباشي خلف الزبيدي
الموضوع العام: الفنون الجميلة
السنة: 2014
الموضوع الدقيق: الفنون السينمائية
الدرجة: دكتوراه
الجامعة: جامعة بغداد
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Form engaging in philosophical modernist structure speech Alcinmaturav phenomenon articulated it and the latest irregularities unprecedented make it produces or generates a logic of its own and in order to examine this Alachtgalat This study tagged ( representations of philosophical modernity in a speech Alcinmaturav ) which are arranged through the chapters four came first in which the title frame systematic and included a research problem and its importance and its goals and limits of the most prominent and the terms contained in its title as well as the paragraph previous studies. While the second quarter and marked the theoretical framework on four key sections as follows : First research \ entrance to process philosophy historically , functioning Alcinmatugrave.The second topic \ philosophical trends and strategy in assimilation.The third topic \ modernity ( the project and assimilation Alcinmatugrave.The fourth topic \ representations philosophy of modernity in the structure of assets Alcinmaturav speech.The researcher reviewed the first section of the panorama of historical experienced by the philosophy through the ages , pointing to the most prominent names of the task and milestones witnessed by philosophical thought , while touched second section of the most important trends philosophical shining four trends are ( pragmatism and existentialism and Marxism and idealism ) and noting some of the Achtgaladtha and Tmtheladtha Alcinmaturav in the structure of speech , and singled out the third section of the contest in the term and concept of modernity and its most prominent thinkers of the Enlightenment and in the film Achtgaladtha Alcinmatugrave money while the fourth section to the practical applications of philosophical representations of modernity in the structure of the elements of audio and visual components of speech Alcinmatugrave.Through review of the most prominent theoretical perspectives and institutions Alalstamologih constituents thought the philosophies of modernity researcher unearthed a number of indicators conclusion theory for the second semester and adopted as one of the research tools and a standard measure by the elected Qsidia research specimens.The third chapter , entitled action research has consisted of research methodology used and the research community , and specimens marked by models film following ( The Last Samurai , The Devil's Advocate , Mr. Nobody , Homes in that alley, an avatar ), which cited a researcher some justification for some reason selected , and also contained this chapter the search tool and the unit of analysis as well as samples paragraph film , which relied on what Achtgah researcher of the standard indicators of research theoretical framework after obtaining the approval of the Committee of Experts and Mahknyn it.The fourth and final chapter has been included on most final results derived from the analysis of the samples of the five film and that was the most prominent : 1 - The statements and perceptions problem of philosophical thought Batjahath four ( pragmatism , existentialism , Marxism , idealism ) and Tmtheladtha in the structure of speech Alcinmaturav remain in character and descriptive abstract , and remain within this space even linked to the content is appointed in life or art , and then reflected across assets or elements pampering filming to produce a concept or connotation.2 - show that modernity has Mthaana irregularities within the drift has specific knowledge of their requirements and the logical and technical reflected in the building and the Metn Gaii speech Alcinmaturav unconditionally college , but his being in positions Mtaana it ( footage , scenes , parts, chapters.... etc. ).3 - to remain philosophical representations that the receiver always seek effective and positive for the acquisition of meaning and understanding of the significance , and that the psychological needs of the recipients constantly intervene to read or identify those representations , and Lighting essence through the structure of the assets of the synthetic speech Alcinmaturav.It also included a chapter on conclusions Achtgaha researcher of search results and recommendations as it deems necessary , as well as suggestions for future studies of the suffix with the thrust of this study In conclusion cited researcher list of sources and scientific references adopted in consideration and some supplements and abstract in English.

التحول المفاهيمي للبنية الزخرفية في العمارة الاسلامية Conceptual Transformation In The Structure of The Ornamentation Islamic Architecture

اسم المؤلف: وسام كامل عبد الامير
اسم المشرف: جواد عبد الكاظم فرحان الزيدي
الموضوع العام: الفنون الجميلة
السنة: 2014
الموضوع الدقيق: الخط والزخرفة
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية الفنون الجميلة - قسم الخط العربي والزخرفة
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تناول الفصل الاول مشكلة البحث التي طرحت التساؤل الاتي ( ما هو التحول المفاهيمي للبنية الزخرفية في العمارة الاسلامية ؟)، ويهدف البحث الى كشف وتحديد التحول المفاهيمي للبنية الزخرفية في العمارة الاسلامية على الصعيد الشكلي والوظيفي والتعبيري في ضوء حدود تمثلت | First Chapter deals with the problem of the research which presents the following question(What is the conceptual transformation in the structure of the ornament Islamic architecture ?) The research aims to disclose and specify the conceptual transformation in the structure of the ornament Islamic architecture at the phases of formal, functional and expressive in light of the limits of ornament components in all its kinds in Islamic architecture within Iraq , Turkey, and Iran for the duration of 1563 AD to 2009 AD. Second chapter discusses the theoretical frame of the following subjects : The meaning of converting and its philosophy in Islamic art at the phases of self and subject , the philosophy of concepts in Islamic ornament as perfection and order and repetition and decoration and unity and variety and movement and rotation and accuracy and workmanship, and the styles of formulation of decorative shape represented in modulation style and style of abstraction , and the structure of the decorative in Islamic architecture at the phases of decorative components and spatial organization and processors colorimetric. Third chapter includes the research's procedures which includes the follow of descriptive approach in the light of research's sample which includes 375 shapes non - recurring. 20 shapes were selected embodied the research's sample according to the method of intentional selection. The tool of the research was designed ( analyses form) and shown to experts in order to obtain their reliability and validity and then analyses of the samples. The fourth chapter includes the results including : 1 - to pursue the conceptual transformation of the ornament structure in Islamic architecture within several axes such as formal, functional and expressive. formal phase includes the following ; 1 - 1 style of shape's formation in terms of the type and quality. It is represented in some methods such as (offloading , replacement , integration ( formal slurring) , substitution , magnification and reduction). 2 - Conceptual transformation of ornament structure at the level of functional side embodied in transmission from the ornament role to openness of the performance of the dual role (decorative - communicative) reflected by designed components through dual superficial structure by two different ornament sorts ( calligrapher - plant ). Transmission from ornament function to the representation of narrative phase presented by details of decorative structure which reflect realistic scenes of life include various expressive subjects. 3 - Conceptual transmission of the ornament structure on the expressive level which is embodied by transmission from imitation of images of the natural existence world ( plant - animal - clouds) , cognitive existence world ( geometrical ) postural (calligrapher) which depends on the metaphor , comparison , and equivocation between the real shape and ( true ) and decorative transmission ( metaphor) via visual signifier and its attribution which is involving the concepts can be understood through phenotypic approach to the ornament icons which state subjects such as ( fighting scenes with fabled creature , hunting scenes , beyond being of the world as a man has two wings ).4 - concept of perfect ness embodied through presenting several comprehensive image to the details of ornament structure which reflects the side of realistic existence elements with shapes that represent this vision in terms of quantity (creation of unilateral and bilateral and multi ornament sorts ) and the quality ( symmetrical , non - symmetrical , round , sidelong , frontal , compound , start of emergence , medial site , final site , small size , large size ) and the type ( plant , geometrical , animal , calligrapher , astronomical elements , supernatural). Transformation of the concepts of the integrated form ornament sort ( bilateral , tripartite , quaternary) depends on the integration with other via combination and replacement between the different parts.The study recommends providing care for the accumulated ornament heritage throughout centuries when maintenance and renewal given the contents of innovative treatments in formulating the shape and concepts within it , which reflects the growth of thought and its appearance applications through a formal shifts represent addition of quality different from the prevailing in the achievement side , and the possibility of opening up its functions to cover the fields of design carpets and paintings. The study suggests references of shape and its representations in the structure of ornament Islamic Architecture.
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