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الخصائص الميكانيكية الكهربائية والحرارية لمتراكبات البوليمر - انابيب الكاربون النانوية == Polymer - Carbon Nanotube Composites Mechanical, Electrical And Thermal Properties

اسم المؤلف: فاطمة احمد خلف
اسم المشرف: نجيبة عبد الله حسن الحمداني | طارق سهيل نجم
الموضوع العام: علوم الفيزياء
السنة: 2014
الموضوع الدقيق: الفيزياء
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعتبر البوليمرات ذات الاساس البوليمري من اهم المتراكبات بسبب قابليتها على الاندماج مع عدد من مختلف المواد. تم التركيز في هذه الدراسة على تطوير ودراسة خصائص متراكبات نانوية متكونة من الراتنج epoxy)) المتصلد حراريا كمادة اساس مضاف اليها الانابيب الكاربوني | Polymer matrix composites (PMCs) are one of the most important composites materials due to their ability to incorporate a number of different materials. This study focuses on development and characterization of thermosetting resin epoxy based nanocomposit

تصنيع وتوصيف خلايا شمسية مرنة == Fabrication And Characterization of Flexible Solar Cells

اسم المؤلف: علي محسن عبد الحسين اللامي
اسم المشرف: زينب عبد السلام الرمضان | فلاح ابراهيم العطار
الموضوع العام: علوم الفيزياء
السنة: 2014
الموضوع الدقيق: الفيزياء
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعد الانظمة الفوتوفولتائية من مصادر الطاقة النظيفة والتي بدات تاخذ مساحة مهمة من البحث، ان الاغلبية من الخلايا الشمسية تتميز بكونها صلبة ولم يراعى فيها عامل المرونة, لذا توفر الانظمة الفوتوفولتائية المرنة عدة ميزات في مجال سهولة النقل, مقاومة الكسر وخفة | As a source of clean, remote energy, photovoltaic (PV) systems are an important area of research. The majority of solar cells are rigid materials with negligible flexibility. Flexible PV systems possess many advantages, such as being transportable, unbrea

تحضير ودراسة بعض الخصائص الفيزيائية للمتراكب البوليمري النانوي PMMA/ZrO2 == Prepration And Studay Some Physical Properties of Polymeric Nano Compsite (PMMA / ZrO2)

اسم المؤلف: نور ظايف حايف
اسم المشرف: نجيبة عبد الله حسن الحمداني
الموضوع العام: علوم الفيزياء
السنة: 2015
الموضوع الدقيق: الفيزياء
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تم في هذا البحث تحضير المتراكبات النانوية للبوليمر المطاوع للحرارة بولي مثيل ميثااكريلايت (PMMA) والمدعم بالجسيمات النانوية اوكسيد الزركونيوم ( ZrO2), وبحجم حبيبي (40 - 50nm) وبكسور وزنية مختلفة) wt%1,1.5,2.5,3,5(0, باستخدام الكلوروفورم كمذيب بطريقة صب ال | In this research, nanocomposites of thermoplastic polymer (Poly Methyl Methacrylate, PMMA) and nanoparticles reinforcement (Zirconium Oxides, ZrO2) have been fabricated with grain size (40 - 50nm) with different weight fraction (0, 1, 1.5, 2.5, 3 and 5 wt

تحضير ودراسة اغشية ZnO : Mn ذات التركيب النانوي بتقنية الترسيب البخاري الكيميائي تحت الضغط الجوي الاعتيادي == Preparation And Study of Nanostructure ZnO : Mn By Atmospheric Pressure Chemical Vapor Deposition Technique

اسم المؤلف: هبة راشد شاكر
اسم المشرف: صلاح قدوري هزاع
الموضوع العام: علوم الفيزياء
السنة: 2014
الموضوع الدقيق: الفيزياء
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تم في هذا البحث تصميم وتصنيع منظومة الترسيب البخاري الكيميائي عند الضغط الجوي الاعتيادي ذات الجدار البارد محليا, وتشغيل المنظومة للحصول على افضل غشاء بواسطة تغيير ظروف التشغيل من حيث درجة حرارة القاعدة, زاوية ميلان القاعدة, موقع القاعدة داخل المنظومة, ك | In this research, atmosphere pressure chemical vapor deposition system, with cold wall has been designed and locally manufactured. This system operated to get the best thin film by changing the conditions of performing such as; substrate temperature, slop

دراسة تاثير السمك والتركيز على الخصائص الكهربائية والبصرية لـ بولي مثيل ميثاكريلات المشوب بملح التيتانيوم TiCl3 == Study The Influnce of Concentration And Thickness on Electrical And Optical Properties of PMMA / Ti Cl3 Salt Composite

اسم المؤلف: فاضل تركي معن
اسم المشرف: زينب عبد السلام الرمضان
الموضوع العام: علوم الفيزياء
السنة: 2009
الموضوع الدقيق: الفيزياء
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تم في هذا البحث تحضير البوليمر بولي مثيل ميثاكريلات PMMA العازل اللدائني الشفاف بعملية بلمرة الاضافة الحجمية بواسطة الجذور الحرة باضافة البادئ بنزول بيروكسايد الى المونومير MMA.تم قياس اللزوجة باستخدام جهاز قياس اللزوجة عن طريق اخذ تراكيز مختلفة من النمو | In this research, The preparation of poly methyl methacrylate PMMA (the transparent plastic insulator) by polymerization the added volume by free radicals after adding the initator Benzoyl peroxide to the MMA monomer. The viscosity were measured by viscom

دراسة الخصائص البصرية والتركيبية لاغشية cdo الرقيقة المحضرة بطريقة الترسيب بالحمام الكيميائي == Study The Optical And Structural Properties of CdO Thin Films Prepared By Chemical Bath Deposition Method

اسم المؤلف: كرار مهدي صالح
اسم المشرف: فاطمة ياسين محمد
الموضوع العام: علوم الفيزياء
السنة: 2015
الموضوع الدقيق: الفيزياء
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: حضرت اغشية اوكسيد الكادميوم (CdO) الرقيقة من مادة كلوريد الكادميوم المائية (CdCl2.2H2O) ذات الوزن الجزيئي (201.33g/mol) وبتركيز مولاري (0.1M) على قواعد زجاجية بدرجة حرارة الغرفة(RT) بطريقة الترسيبب بالحمام الكيميائي. وقد تم دراسة تاثير السمك (t=127.35,241 | Thin films of cadmium oxide (CdO) have been prepared from 0.1M Cadmium Chloride dehydrate (CdCl2.2H2O) with molecular weight 128.4g/mol on glass substrates at room temperature (RT) by chemical bath deposition method (CBD). The influence of thickness (t=12

الخواص التركيبية والبصرية لاغشية Fe2O3 - NiO المحضرة بطريقة التحلل الكيميائي الحراري == The Structure & Optical Properties of (Fe2O3 - NiO) Thin Films Prepared By The Chemical Spray Pyrolysis

اسم المؤلف: نورا جاسم محمد جبر
اسم المشرف: نادر فاضل حبوبي
الموضوع العام: علوم الفيزياء
السنة: 2014
الموضوع الدقيق: الفيزياء
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: حضرت اغشية اوكسيد الحديديك ( Fe2O3 ) واغشية اوكسيد الحديديك الممزوجة باوكسيد النيكل NiO)) من المحاليل المائية لكلوريد الحديد الثلاثي (FeCl?.6H2O) وكلوريد النيكل (NiCl2.6H?O) بنسب مزج (% 10,20,30,40,50) بطريقة التحلل الكيميائي الحراري على قواعد زجاجية بدرج | Ferric Oxide (Fe2O3) and Nickel oxide (NiO) Mixed with Ferric Oxide thin films were prepared from an aqueous solution of [FeCl¬3.6H2O] Nickel chloride [NiCl2.6H?O] in volumetric concentration (10,20,30,40,50%) by chemical spray pyrolysis method onto glass

تصميم مضخة هجينة شمسية - جيوحرارية == Design of Hybrid Solar - Geothermal Heat Pump

اسم المؤلف: علاء حسين شنيشل السوداني
اسم المشرف: احمد فرحان عطوان | نصير كريم قاسم السوداني
الموضوع العام: علوم الفيزياء
السنة: 2014
الموضوع الدقيق: الفيزياء
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: مصادر الطاقة التقليدية مضرة بيئيا على العكس من مصادر الطاقة المتجددة. سعى العالم سوية في نهاية القرن الماضي الى تشخيص مشاكل تغير المناخ الذي ادى بدوره الى التفكير في سبل حفظ الطاقة والتقليل من الانبعاثات. تعتبر طاقة الجيوحراري (Geothermal energy) من الطاق | Conventional energy resources are environmentally harmful unlike renewable energy resources. At the end of the last century the world came together to address the problems of climate change; which led to the thinking of ways to conserve energy and reduce

الخزن الموسمي للطاقة الشمسية الحرارية : دراسة نظرية == Theoretical Study of Seasonal Storage Thermal Solar Energy

اسم المؤلف: فاضل محمود عليوي
اسم المشرف: احمد فرحان عطوان | نصير كريم قاسم السوداني
الموضوع العام: علوم الفيزياء
السنة: 2014
الموضوع الدقيق: الفيزياء
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: يتناول هذا البحث تخزين الطاقة الشمسية الحرارية الفائضة في فصل الصيف ( من ايار الى تشرين الاول) في داخل التربة، للاستخدام لاحقا ( في فصل الشتاء) للحد من استهلاك العالي للطاقة المستخدمة وكذلك لتقليل انبعاث غاز ثاني اوكسيد الكاربون. استخدم نموذج شبه ثلاثي ال | This research deals with storage of the thermal solar energy in the soil in summer season (from May to October) for latter utilization (in winter) for reduce the energy consumption. The quasi - three - dimensional model and finite line source model are us

دراسة تاثير البروبايويك في تكوين الغشاء الحيوي وانتاج البروتيز لبكتريا Pseudomonas aeruginosa المعزولة من اخماج الحروق والجروح == Study The Effect of Probiotic On Biofilm Formation And Production Protease Enzyme By Pseudomonas Aeruginosa Isolated From Contaminated Burns And Wound

اسم المؤلف: علا عبد الكريم كاظم النعيمي
اسم المشرف: منيرة جلوب اسماعيل العبادي | ضيماء محمود ابراهيم
الموضوع العام: علوم الحياة
السنة: 2015
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: he study includes the collection of 70 burns and wound swabs from patients of different hospitals, in Baghdad area, for the period from November 2013 to February 2014. 2) 31 isolates characterized as Pseudomonas aeruginosa 9 (45%) from wound and 22 (78.57%) from burn swabs, depending on the characteristics of the colonies phenotypic and microscopic when grown in differential selective media, as well as biochemical tests todiagnose isolates, Then the identification of these species were confirmed by using the system (GN I Card) using Vitek 2 device complementary step.3) The study includes sensitivity test towards 16 antibiotics for each species by using the system (AST Card) using Vitek 2 device, and the isolates ware Multi drug resistance, As results all isolates were resistant by 100 % for each of Piperacillin, Ticarcillin, Ticarcillinclavoulanic acid, Cefazolin, Ceftriaxone and Tigecycline. All strains were less resistance to Ceftazidime with percentage 50%. 4) All the isolates of Pseudomonas aeruginosa with percentage %100, have ability to produce protease enzyme.5) This study was use tow methods of biofilm formations seen in P. aeruginosa, Micro - titer plate method (MTP) and Tube method (TM), Results revealed that MTP was found to be more sensitiveand specific method for biofilm detection than TM. 6) Well diffusion method revealed the inhibitory effect of bacteria Lactobacillus acidophilus, Lactobacillus rhamnosus GG and its supernatants in the growth of bacteria Staphylococcus aureus and P. aeruginosa, and was the supernatant of L. rhamnosus GG isthe largest inhibitory effect on the growth of S. aureus and P.aeruginosa with inhibition diameter 32 and 34 mm respectively, while the inhibition of growth by supernatant of L. acidophilus diameter 25 and 27 mm respectively. 7) Estimated the amount of protein in each of the biosurfactant and bacteriocine producers of L. rhamnosus GG bacteria concentration of 74, 54 Mg/mL respectively, while their concentration in bacteria L. acidophilus 44, 40 Mg / mL, respectively.8) Found that the bacteriocine product of bacteria L. rhamnosus GG and L. acidophilus GG have inhibitory effect on ability of P. aeruginosa to produce the enzyme protease, and the absence of this effect in the Biosurfactants the product of these two types.9) The biosurfactant product from L. rhamnosus GG showed inhibitory effect greater than the effect of the biosurfactant product from L. acidophilus to inhibition (production of biofilm and adhesion to epithelial cells).10) studied the suspension's effect of L. acidophilus and L. rhamnosus GG in contrived injuries wounds in mice contaminated with P. aeruginosa, Positive results have been shown to be affected by the contaminated bacteria injuries wounds.

دراسة تصنيفية لحشرات عائلة الخنافس الرواغة Staphylinidae : Coleoptera في بعض محافظات العراق

اسم المؤلف: كاظم عادل هادي
اسم المشرف: سعدون ابراهيم اسماعيل
الموضوع العام: علوم الحياة
السنة: 2015
الموضوع الدقيق: الحيوان - الحشرات
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:

دراسة مقارنة للتاثير السمي للزنبور الاحمر Vespa Orientalis L والزنبور الاصفر Polistes Olivaceaus (De Geer) (Hymenoptera : Vespidae على تحلل كريات الدم الحمراء والتخثر لدى الانسان == Poison Effects of Red Wasp Vespa Orientalis L. And Yellow Wasp Polistes Olivaceaus (De Geer) (Hymenoptera : Vespidae) On The Decomposition of Red Blood Cells And Coagulation In Humans

اسم المؤلف: شهد فلاح عباس
اسم المشرف: سعدون ابراھیم اسماعیل | محمد عبد الرزاق الصوفي
الموضوع العام: علوم الحياة
السنة: 2014
الموضوع الدقيق: الحيوان - الحشرات
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: To study the impact of toxic of the the Red Wasp Vespa orientalis L. and yellow wasp Polistes olivaceaus (De Geer) from family (Vespidae) the decomposition of red blood cells and clotting in humans. Were collected 508 insect Red wasp was where the number of workes 390 insect the yellow wasp gathered 539 insect where the number of worker 418 insect, and the diagnosis was confirmed based on the taxonomic keys and professors speclalized in the natural history museum and then extracting machine stinging for poisonWasp red and yellow toxin were purified by gel filtration throw Sephacryl S - 200 were obtained on three peaks of proteins, and when estimated the activity of lysis and clotting for peaks separate P1, P2 and P3 for wasp red toxin, the lysis activity of separate P1 was 98% of the poison origin activity and the clotting time was 47.3 minutes, while the lysis activity of separate P2 was 62% of the poison origin activity and the clotting time was 27.53 minutes, and the lysis activity of separate P3 was 29% of the poison origin activity and the clotting time was 13.67 minutes, so P1 separate from Wasp red poison was selected to purification and study the molecular characteristics, while when estimated the activity of lysis and clotting for peaks separate P1, P2 and P3 for wasp yellow toxin, the lysisactivity of separate P2 was 91% of the poison origin activity and the clotting time was 43.8 minutes, while the lysis activity of separate P1 was 49% of the poison origin activity and the clotting time was 19.28 minutes, and the lysis activity of separate P3 was 29% of the poison origin activity and the clotting time was 7.52 minutes, so P2 separate from wasp red poison was selected to purification and study the molecular characteristics The molecular weight of wasp red and yellow toxin the protein cm wasp red toxin P1 was 22387 Da and wasp yellow toxin P2 was 22382 Da using the gel filtration Sephacryl S - 200, while the carbohydrates content were 60.057 and 44.460 mg/ ml for wasp red P1 and yellow P2 toxin respectively as determined by phenol - sulfuric acid method, and type of link between carbohydrates and protein in the separate P1 and P2 investigating by using gel filtration Sephacryl S - 200 and absorbance at 280 and 490 nm.The percentage of iron in wasp red P1 and yellow P2 toxin were 0.88 and 0.44 ppm respectively as determined by atomic absorption, the contain proteins separate P1 and P2 on the iron were investigating by using gel filtration Sephacryl S - 200 and absorbance at 280 and 557 nm. The optimum pH of lysis and clotting activity for wasp red toxin P1 was 6.5, while lysis activity was decrease in pH 4 and 8 to be 38 and 79% respectively from its original activity, and clotting time was decreased from 47.3 min at optimum pH to be 17.9 and 37.3 min at pH 4 and 8, respectively, it was noted that wasp red toxin P1 was constant in the pH range of lysis activity from 6 - 7.5, but it lost 67 and 25% from its original activity at pH 4 and 8 respectively, while the clotting time was constant in the pH range from 6 - 7.5, but it decreased in pH 4 and 8 to be 15.6 and 35.4 minutes respectively The optimum pH of lysis and clotting activity for wasp yellow toxin P2 was 6.5, while lysis activity was decrease in pH 4 and 8 to be 18 and 37% respectively from its original activity, and clotting time was decreased from 48.8 min at optimum pH to be 8.7 and 35.6 min at pH 4 and 8 respectively, it was noted that wasp red toxin P2 was constant in the pH range of lysis activity from 5.5 - 8, but it lost 74 and 19% from its original activity at pH 4 and 8 respectively, while the clotting time was constant in the pH range from 6 - 7.5, but it decreased in pH 4 and 8 to be 12.6 and 39.5 minutes respectively The results for optimum stability temperature of lysis and clotting activity for wasp red toxin P1 refer to increase activity by increasing the action temperature until it reached a maximum at a temperature 35oC, then lysis activity was decreased to be about 4% of its original activity at 80oC, while the clotting time was decrease from 48.8 minutes at the optimum temperature to be 1.8 minutes at 80oC, it was noted that the lysis and clotting activity were stabile at 35oC for 30 min, but it is beginning to decrease with increasing temperature to loses 84% of its original lysis activity at 80oC, and the clotting time was decreased from 47.3 min at 35oCto be 2.3 min at 80oC.The results for optimum stability temperature of lysis and clotting activity for wasp yellow toxin P2 refer to increase activity by increasing the reaction temperature until it reached a maximum at a temperature 35oC, then Lysis activity was decreased to be about 8% of its original activity at 80oC, while the clotting time was decrease from 48.8 minutes at the optimum temperature to be 3.9 minutes at 80oC, it was noted that the lysis and clotting activity were stabile at 35oC for 30 min, but it is beginning todecrease with increasing temperature to loses 98% of its original Lysis activity at 80oC, and the clotting time was decreased from 48.8 min at 35oC to be 5.3 min at 80oC.The results refer to found a relationship between the influence of the wasp type and dose on the red blood cells lysis degree in males and females, it was observed that the concentration had a significant effect (p<0.05) in the red blood cells lysis degree in females, it was 0.401 at concentration 100% for wasp red toxin P1, while it was 0.331 at the same concentrate for wasp yellow toxin P2, the concentration also had a significant effect (p<0.05) in the red blood cells lysis degree in males, it was 1.020 at concentration 100% for wasp red toxin P1, while it 0.842 at the same concentrate for wasp yellow toxin P2, also it refer to found a significant effect (p<0.05) between the effect of the wasp red P1 and yellow P2 toxin and dose on the red blood cells clotting time in females, itwas 46.80 min at concentration 100% for wasp red toxin P1, while it was 46.20 min at the same concentrate for wasp yellow toxin P2, the concentration also had a significant effect (p<0.05) in the red blood cells clotting time in males, it was 47.80 min at concentration 100% for wasp red toxin P1, while it 40.47 min at the same concentrate for wasp yellow toxin P2, there was no significant effects for blood clotting time when making a comparison between the wasp red P1 and yellow P2 toxin for eachconcentration in females and males. The compared between red blood cells clotting time due the wasp red P1 and yellow P2 toxin dose in females and males did not refer to found a significant effect (p<0.05), the clotting time for wasp red P1 was 46.80 and 47.80 min at concentration 100% for females and males respectively, while the clotting time at concentration 6.25% was 17.30 and 17.10 min for females and males respectively, whilst the clotting time red blood cells due wasp yellow P2 toxin in females was 46.20 min and 47.40 min in males at concentration 100%, and it was 17.00 min in females and 17.10 min in males at concentration 6.25%.

دراسة تصنيفية لعويلة الخنافس البرغوثية Alticinaeمن عائلة Chrysomelidae ورتبة غمدية الاجنحة Coleoptera في بعض محافظات العراق == Taxonomic Study On The Flea Beetles (Coleoptera : Chrysomelidae : Alticinae) In Some Provinces of Iraq

اسم المؤلف: رغد عـبيد خضير
اسم المشرف: سعدون ابراهيم اسماعيل
الموضوع العام: علوم الحياة
السنة: 2014
الموضوع الدقيق: علوم الحياة
الدرجة: ماجستير
اللغة: العربية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تناول البحث لهذه الرسالة دراسة تصنيفية لعويلة الخنافس البرغوثية Alticinae في بعض محافظات العراق، علما ان هذه العويلة لم تدرس تصنيفيا في العراق.اختير النموذج Longitarsus ballotae Marsham. لتجسيد صفات العويلة. ولقد درست الاجزاء الرئيسة للجسم وهي الراس والص | The Subject of thesis is a taxonomic study of Subfamily Alticinae in some provinces of Iraq. Knowing that this Subfamily has not been studied taxonomically in Iraq.Was chosen as the model for Longitarsus ballotae Marsham. To embody the gualities of the Subfamily. The detailed study of the head, thorax, abdomen and their appendages was made to evaluate the reliability of the external characters in classifying the species of the Subfamily.There are eight genera and thirteen species for these Subfamily The species are : - Altica deserticola Weise.Aphthona fuentei Reitter.Aphthona sp. Chaetocnema montenegrina Heikertinger.Chaetocnema persica Baly. Epitrix atropae Foudras.Hermaeophaga ruficollis Lucas.Longitarsus ballotae Marsham.Longitarsus membranaceus Foudras.Longitarsus reichei Allard. Longitarsus succineus Foudras.Phyllotreta nemorum Linnaeus.Podagrica fuscicornis Linnaeus.6 Species Register in Iraq are : - Chaetocnema montenegrina Heikertinger.Epitrix atropae Foudras. Longitarsus succineus Foudras.Longitaarsus membranaceus Foudras.Podagrica fuscicornis Linnaeus.Two species Taxonomic keys were designed and developed to is olate the genera of Subfamily Alticinae, sa wellas the genera mentioned and studied in this thesis for each species.

كفاءة التنظيف لمبرد XP - endo Finisher بالمقارنة مع انظمة الارواء بالتردد الصوتي والتردد فوق الصوتي : دراسة خارج الجسم == Cleaning Efficiency of Xp - Endo Finisher File In Comparison With Sonic And Ultrasonic Irrigation Systems (An In Vitro Study)

اسم المؤلف: مهند غازي عزاوي
اسم المشرف: جمال عزيز مهدي
الموضوع العام: طب الاسنان
السنة: 2016
الموضوع الدقيق: معالجة الاسنان
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: This in vitro study was conducted to evaluate and compare the efficiency of XP - endo Finisher, EndoActivator sonic irrigation system and the NSK Varios ultrasonic irrigation system in removing dentin debris at three levels of root canals and to compare the percentage of dentin debris among the three levels for each irrigation system. Sixty freshly extracted upper molar teeth with straight palatal root canals were used in this study. All canals were prepared with ProTaper NEXT rotary files to size X4, 1mm from the anatomic apex with irrigation of 1 ml 2.0% NaOCl between the files. After that the samples were randomly distributed into three groups of twenty samples each, irrigated with 1 ml 2.0% NaOCl, followed by irrigant activation for 60 seconds with three different irrigation systems; group one, by using the XP - endo Finisher; group two, by sonic irrigation using the EndoActivator system; and group three, by ultrasonic irrigation using the NSK Varios, then all the groups received a final rinse of 5 ml 2.0% NaOCl. After the final rinse, the roots were split longitudinally into two parts and photographed with a professional digital camera. The digital images were then transferred into a computer and opened in Adobe Photoshop CC 2015 software and the canal was magnified 200x. The percentage of dentin debris remaining at the apical level (0 - 3mm), the middle level (3 - 6mm) and the coronal level (6 - 9mm) was calculated by dividing the number of pixels occupied by the dentin debris at each level by the number of pixels representing the entire canal area. Data were analyzed statistically by ANOVA and LSD at 1% and 5% significant levels. This study showed that cleaning the canal with the XP - endo Finisher or NSK Varios ultrasonic irrigation system resulted in significantly cleaner canals (P<0.01) than the EndoActivator sonic activation system at all canal levels. The XP - endo Finisher resulted in cleaner canals than the NSK Varios ultrasonic irrigation system at all levels, but the difference is not statistically significant (P>0.05). The apical level of all the canals showed a greater amount of dentin debris (P<0.01) compared to the middle and coronal levels, regardless of the irrigation device used.

تحليل القوى المستقرة لثلاثة انواع مختلفة من المواد الراتنجية بطريقة عملية وعددية == Static Stress Analysis For Three Different Types of Composite Materials Experimentally And Numerically

اسم المؤلف: محمد وائل سعيد
اسم المشرف: حكمت عبد الرحيم الغراوي
الموضوع العام: طب الاسنان
السنة: 2016
الموضوع الدقيق: معالجة الاسنان
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: t is important to analyze and compare the stresses induced in different composite material types during load application to know which type of composite will behave as preferred under the loading in the same circumstances. This study aimed at measuring and comparing the stress induced in Filtek ™ Z350 XT (3M ESPE) composite, Tetric EvoCeram ® (ivoclar vivadent) composite and BRILLIANT ™ NG (Coltène/Whaledent) composite experimentally and numerically.Experimental analysis included cavity preparation in the Brass block with a concave (U - shape) cavity which represent a proximal cavity preparation. This cavity was used as a mold for sample preparation. The internal line and point angles of the cavity (mold) were rounded and the dimensions of the cavity (mold) were 10mm × 10mm × 10mm (Total height of the box × Width of the top side of box × Length of the top side of box). The internal diameter of “U” was 5 mm at the base of the box. The mold was used to prepare forty five samples, fifteen samples for each type of composite material. So, three groups were prepared : Group A filled with Filtek ™ Z350 XT composite material, Group B filled with Tetric EvoCeram ® composite material and Group C filled with BRILLIANT ™ NG composite material.Electrical strain gauge (Tokyo Sokki, Japan) was embedded in composite material horizontally at the same level in each sample. Static load of 50 N was applied perpendicular to the center of the occlusal surface of composite restoration in each sample testing. The strain gauge was connected to a Wheatstone bridge with a signal amplifier which measures the strain during load application and gives the amplified signal from (0 to 4.8 volt) to LabJack data acquisition where a stream software give the final values of strain with the aid of a scaled equation of voltage. Then, the von Mises stress (effective stress) was calculated by using equations. Numerical analysis was done by using ANSYS 16.1 - (2015) (finite element tool) software that was used to create the 3 - Dimensional models represented the same materials and dimensions used experimentally. The physical characteristics of the composite models were inserted in the software which included Elastic modulus and Poisson’s ratio (?). Analysis was selected in a finite element method according to boundary conditions. A mesh size and an element size were estimated during the study. The stresses were calculated at static load of 50 N with the ANSYS 16.1 - (2015) software.The data were analyzed statistically by One - way ANOVA test and Least Significant Difference (LSD) test. One - way ANOVA test and LSD test results showed that there was a highly significant difference (P<0.001) presented between groups A and B, groups A and C and between groups B and group C. The Stress induced in BRILLIANT ™ NG composite after load application was the lowest stress value followed by Tetric EvoCeram ® composite and followed by Filtek ™ Z350 XT composite which was the highest stress value experimentally and numerically.

التسرب المايكروي لنوعين من القشرة الخزفية بوجود وعدم وجود الحشوة الراتنجية تحت جهاز التحميل الدوري == Microleakage of Two Porcelain Laminate Veneers Materials With And Without Composite Filling Under Cyclic Loading

اسم المؤلف: ياسر علي النقيب
اسم المشرف: عمار عطا الله علي السعدي
الموضوع العام: طب الاسنان
السنة: 2016
الموضوع الدقيق: معالجة الاسنان
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Although investigators have evaluated the microleakage of porcelain laminate veneers, there is insufficient data regarding the durability of porcelain laminate veneers bonded to existing composite fillings. The aim of this study was to evaluate the microleakage of porcelain veneers restorations fabricated from two types of CAD/CAM ceramic blocks bonded to teeth with or without composite class V composite filling.Forty eight sound, crack - free human maxillary first premolar extracted for orthodontic reasons were selected for this study. Teeth were divided randomly into.2 main groups, which further divded into 2 groups (12 sample each). Group A1 : IPS e.max CAD veneers with standardized class V composite filling, Group A2 : IPS e.max CAD veneers, Group B1 : VITA Suprinity veneers with standardized class V composite filling, Group B2 VITA Suprinity veneers. The class V cavities was restored with nanofilled composite (Filtek™ Z350 XT, 3M ESPE). Standard veneer preparations were made using Ceramic veneer burs system (Keramikveneers. de, Komet). All the veneers were milled by CAD/CAM technology (CEREC MC XL, inLab SW 15, Sirona Dental Systems) Composite fillings (groups A1 and B1) were sandblasted with alumina oxide.Porcelain veneers were cemented in place using light - cured resin cement (Rely Veneer Cement, 3M ESPE), Then the specimens were stored at 37? in distilled water for 2 weeks. Then mechanical load cycling (50,000 load cycle of 49 N at 2.5 Hz) and thermocycling procedure (500 cycles of 5 - 55 Co with 20 sec dwell time) were done. The specimens’ crowns were immersed in 2% methylene blue dye for two days, then mounted in clear acrylic before sectioning with a 0.35 mm microtome. Microleakage percentage were recorded using stereomicroscope and ImageJ program. Results were checked for normality of distribution (Kolmogorov - Smirnov test and Shapiro - Wilk test), and were analyzed with twoway ANOVA and independent samples t - tests. Two way ANOVA shows the significant effect of type of ceramic restoration and the highly significant effect of composite filling, however, the interaction between the main factors was non - significant. The results showed that the lowest mean of microleakage percentage was recorded for group A2 (4.6058% ± 1.5091) which considered statistically significant compared to group B2 (6.105%±1.456), and statistically highly significant compared to group A1 (6.6075%±1.3259) while group B1 recorded the highest mean of microleakage percentage (7.3158%±1.38713). In conclusion, the type of ceramic restoration and the presence of class V filling both had significant effects on microleakage of porcelain veneers. IPS e.max CAD veneers had significantly lower microleakage percentages compared to VITA Suprinity veneers. The presence of class V composite filling within the cervical finishing line of porcelain veneers had a highly significant higher microleakage percentage compared to groups without composite filling.

احتمالية حدوث العيوب في عاج الجذر نتيجة لاستخدام انظمة مختلفة من مبارد النيكل تيتانيوم == The Incidence of dentinal root defects caused by different Nickel Titanium instruments

اسم المؤلف: نور الدين علي سعيد
اسم المشرف: ايمان محمد الزقة
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: معالجة الاسنان
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: يعد الاعداد الميكانيكي الاحيائي لقنوات الجذر احد الخطوات الرئيسية لتحقيق حشوة جذر ناجحة بسبب امكانية ازالة الاجسام البكتيرية والحطام المتراكم وتسهيل وضع حشوة الجذر داخل القنوات. الغرض من هذه الدراسة هو لملاحظة ومقارنة احتمالية حدوث العيوب في عاج الجذر نتي | Vertical root fracture and crack formation can be seen in root dentin during and after endodontic procedures. Vertical root fracture is one of the most frustrating complications of root canal treatment, which often results in tooth extraction. The aim of this in vitro study was to compare the effect of different Nickel Titanium instruments (ProTaper Universal, EndoSequence, ProTaper Next and RECIPROC) on the dentinal wall in term of dentinal defects.Seventy - five straight palatal roots of freshly extracted human maxillary first molars teeth were used in this study, the palatal roots were sectioned at 11 mm from the apex and wrapped with two layers of aluminum foil, then placed in the center of elastic silicon mold. Fifteen roots were left unprepared to serve as a negative control group, the remaining 60 roots were divided into 4 groups, each group contained 15 roots : • Group I was prepared by rotary ProTaper Universal system.• Group II was prepared by rotary EndoSequence system.• Group III was prepared by rotary ProTaper Next system.• Group IV was prepared by reciprocating RECIPROC system.All canals were prepared to MAF # 40. After each file size of the (rotary files) or after three pecking motion of the (reciprocating files), the file was removed from the canal and the canal was irrigated with 1 ml of 2% of sodium hypochlorite. All files were cleaned periodically to prevent clogging of flutes during instrumentation. The canal remained patent by insertion size 15 K - file.When the instrumentation was completed, the roots were then embedded in a clear acrylic resin blocks and each root was sectioned into three levels : apical, middle and coronal. All samples were examined from coronal direction under Stereomicroscope. The number and the type of dentinal defects were recorded and classified. The collected data was tabulated and subjected to statistical analysis using chi - square test.The EndoSequence group showed the lowest number of dentinal defects followed by ProTaper Next group and then ProTaper Universal group. The highest number of dentinal defects were observed in RECIPROC group. Chi - square test showed that there were highly significant differences among groups (P < 0.01). The results showed a non - significant difference between EndoSequence and Protaper Next group (p > 0.05), and a significant difference with ProTaper Universal group (P < 0.05) and a highly significant difference with RECIPROC group (P < 0.01). The ProTaper Next group showed a significant difference with ProTaper Universal group and a highly significant difference with RECIPROC groups. There was no significant difference between RECIPROC and ProTaper Universal groups.

انسلاخ المبيضات اللعابي المقاس بواسطة تفاعل البوليميراز المتسلسل الكمي اللحظي كاداة تنبؤ لحصول التهاب المبيضات الفموي عند مرضى الربو المتعاطين لدواء بيكلوميتازون المستنشق == Salivary Candidal Shed Measured By Real Time Quantitative Polymerase Chain Reaction As A Predictor of Oral Candidiasis In Asthmatic Patients On Inhaled Beclomethasone Dp Therapy

اسم المؤلف: نغم قطران رحيم
اسم المشرف: رعد محي الدين حلمي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الربو القصبي المزمن يمثل مشكله صحيه جديه في كل العالم وهو عادة يبدا في عمر الطفوله ويبقى المريض في كثير من الاحيان يتعاطى العلاجات المستنشقه مدى الحياة.انتشار الربو القصبي يزداد في كثير من دول العالم مما يجعله احد الامراض المعيقه والمهدده للحياة باعتبا | Asthma is a serious global health problem that usually starts in childhood and continues along patient’s life and most of them have to take inhaled therapy lifelong. The prevalence of asthma is rising in many countries of the world, making asthma one of the most disabling and life threatening diseases effecting patients with different age groups and social classes with variable clinical spectrums and outcomes starting from mild to severe disabling syndrome rendering nonproductive individuals to severe life threatening and sometimes fatal disease. Those patients continue inhaled steroid therapy for long duration, considered by GINA as first line treatment , however such a treatment is associated with local adverse effects on oral tissues, and one of the main concerns is the development of oral candidiasis, a chronic, potentially invasive, infection of oral tissues with fungus candida species resulting in failure of treatment. The scientific interests about such a serious complication have been raised over the past years and debates continued as the candida is considered one of the normal flora of the oral cavity in most of healthy population, however oral candidiasis in pathogenic forms still occur in immunocompromised patients including asthmatics on inhaled corticosteroid therapy.Aim of the study1. To investigate the effect of inhaled corticosteroid therapy in form of Beclomethasone Dipropionate250 microgram/dose CFC free in asthmatic patients on salivary candidal shed estimating by Real Time quantitative Polymerase Chain Reaction (RT qPCR) applied on direct unstimulated saliva samples.2. Evaluation of this shed as prediction of occurrence of oral candidiasis. Patients, Materials and MethodsThis study was conducted at Al Zahraa consultational Asthma and Allergy center - Baghdad Al Karkh Health Directorate from September 2013 to February 2014.The included patients were divided into 3 groups. Group A included asthmatic patients on inhaled Beclomethasone therapy, group B included asthmatic patients that never used any form of inhaled steroid therapy and group C was those asthmatic patients on inhaled Beclomethasone therapy who developed oral candidiasis. All patients were receiving two daily doses. The same exclusion forma was applied to choose Group D who were control healthy individuals. Each included patients and control cases were instructed to give saliva samples in the standard way and samples taken for estimation of candidal count by real time quantitative Polymerase Chain Reaction.Results During the study period, 698 patients were examined, however only 63 patients were included in the study. Those 63 were classified as follows : 28 patients were found on group, 28 were found on group B and only 7 patients were found on group C and 20 cases were selected in group D as a control.Group C patients were having the highest salivary candidal shed (mean=58.7x106 cn/ml) and longest duration of asthma (Mean=2718 days) and longest duration of Beclomethasone therapy (Mean=2224 days) and this was significantly higher than other groups (p<0.05).Group A patients were having the second highest rank after group C in regard of salivary candidal shed and both duration of asthma and Beclomethasone therapy. Inside each group, duration of asthma and duration of Beclomethasone therapy were associated with moderate positive correlation with salivary candidal shed (R>0.5).Age difference between groups were insignificant and age factor had no correlation with salivary candidal shed inside the groups.Discussion : Salivary candidal shed over the groups was directly related to the duration of inhaled Beclomethasone therapy and duration of asthma. They are significantly higher (p<0.01) as we go further from each group to the next, both appear as the reason behind increased candidal shed in groups A and C.The salivary candidal shed curve will gave us a very useful tool for follow up those patients on inhaled steroid therapy ,In addition , predict the risk of developing oral candidiasis and when to interfere prior to the establishment of Oral Candidiasis state as that we have noticed in the group C, in which it was recommended to stop inhaled steroid therapy and the patients would lose the benefits of the therapy.Conclusions1. Resting saliva samples with realtime quantitative PCR was a rapid and accurate tool in diagnosis of oral candidiasis.2. Salivary Candidal Shed could be used as a tool in predicting oral candidiasis in asthmatic patients on inhaled Beclomethasone therapy.3.Longer duration of asthma and longer duration of Beclomethasone therapy were associated with increased salivary candidal shed and established oral candidiasis have the highest amount of shed.4. Candida albicans are present in the oral cavity of any individual of our population

تقيم التسريب الجزني لمركبات الراتنج للحشوات الخلفية سونك فل مركب مستند على السيلورين ومركب نانوفل مستند على الميتاكرليت في : دراسة مقارنة == Microleakage Evaluation of Sonicfill

اسم المؤلف: مهند احمد الحداد
اسم المشرف: حكمت عبد الرحيم الغراوي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Resin composites have improved greatly since their introduction and are now the materials of choice for most of the restorations. This study was conducted with aim of comparing in vitro the marginal adaptation of three different, low shrink, direct posterior composites Sonic fill™ (nanohybrid composite), Filtek™ P90 (Silorane - based composite) and Filtek™ Z350 (nanofill composite) of a standardized Class V cavity after thermoal cycling. Sixty sound, freshly extracted human premolars were prepared with standardized Class V cavities. The specimens were divided into three groups of twenty teeth each according to the material used : Group A : The teeth were restored with Sonic fill™ posterior composite unidose capsules, Group B : The teeth were restored with a silorane - based posterior composite (FiltekTM P90), Group C : The teeth were restored with nanofill methacrylate - based composite (Filtek™ Z350 XT).After specimens were stored in distilled water at 37°C for 7 days, all specimens were subjected to thermocycling at (5° to 55 °C), then immersed in 2% methylene blue dye for 24 hours. For each group microleakage at the occlusal and gingival regions was estimated by determining dye penetration using scoring system under steromicroscope (10X). The statistical analysis of the results showed that, Filtek™ P90 silorane based composite exhibited the lowest mean of microleakage, with statistically highly significant difference (P < 0.01) when compared with Sonicfill™ composite and Filtek™ Z350 XT nanofill composite. On the other hand, the results of this study showed that Sonic fill™ composite exhibited no significant difference (P > 0.05) as compared with Filtek™ Z350 XT nanofill composite. Also, the results in this study showed that there is a highly significant difference (P < 0.01) in dye penetration between occlusal and gingival regions for each group

تقييم اصابة المفصل الفكي الصدغي عند مرضى الصدفية باستعمال التصوير المقطعي المحوسب للكشف عن التغيرات المفصلية == Evaluation of The Involvement of The Tempromandibular Joint In Patients With Psoriasis Using Computed Tomography For Detection of Psoriatic Arthritis Changes

اسم المؤلف: منتهى فوزي صالح
اسم المشرف: هاجر ابراهيم عبد الله
الموضوع العام: طب الاسنان
السنة: 2015
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اضطرابات المفصل الفكي الصدغي تشير الى مصطلح مركب يحتوي على عدة حالات تتضمن المفصل الصدغي,التركيبات المحيطة او كلاهما.اضطرابات المفصل الفكي الصدغي هي مجموعة اعراض معقدة اكثر من كونها حالة معينة واحدة, ويعتقد انها تنتج من عدة عوامل مثل : العوامل الجينية, ال | Tempromandibular disorders is a collective term, embracing several clinical problems involving the muscles of mastication, temporomandibular joint (TMJ), or both.Tempromandibular disorders is a symptom complex rather than a single condition, and it is thought to be caused by multiple factors like : genetic, developmental and metabolic.TMDs form a cluster of related disorders with common symptoms which include localized pain, limited or asymmetric movement, and clicks or grating on opening.Psoriatic arthritis is a chronic inflammatory arthropathy that affects patients with psoriasis. Psoriatic arthritis is most commonly a seronegative oligoarthritis found in patients with psoriasis and therefore occurs more commonly in patients with tissue type HLA - B27. The clinical findings for Tempromandibular Psoriatic arthritis are pain, tenderness, limitation of movement , joint stiffness, clicking as the jaw is opened or closed, difficulty in opening the mouth, locking of the jaw,and crepitations. These findings are essentially the same as for Tempromandibular disorders.• Objective of the study : • To determine the extent of tempromandibular joint involvement in patients with psoriatic arthritis.• To correlate between clinical findings and radiographic finding.Materials and method : In this study 98 patients were selected ,50 male and 48 female, their age ranged between(18 - 68)years. They were collected at Al - yarmook teaching hospital/department of dermatology during the period from ( NOV 2014 - May 2015).They were diagnosed as having psoriatic arthritis by a dermatologist according to (Moll and Wright diagnostic criteria 1973).These patients were sent to rheumatoid factor test RF to exclude the presence of rheumatoid arthritic disease, then the patients were exposed to CT scanning for the Tempromandibular joint in Al - Yarmook teaching hospital for screening the involvement of TMJ with psoriatic arthritis by the presence of any radiographic changes such as erosion, flattening,osteophyte and sclerosis in the condylar head.Results : The result of the study showed that the mean age of psoriatic arthritic patients in TMJ was (44.2) years, and the female percentage was (48.4%) and the male was (51.6%). Psoriatic arthritis in TMJ showed high significance in the unilateral side symptoms (100%) it was significant in patients with positive family history (54.8%), and non significant in the right/left ratio (41.9%). Oligo type was found in twenty six patients (83.9%) with significant p - value. Clinically, all symptoms including clicking, tenderness and tempromadibular joint pain were highly significant, limitation showed (54.8%), TMJ pain showed (64.5%) and tenderness showed (54.8%).Radiologically : CT scan showed sensitivity for erosion in TMJ (54.8%), for osteophyte (32.3%), for condylar flattening (16.1%) and for sclerosis (9.7%) while specificity for all were (100%). Association between clinical symptoms and radiological changes showed non significant correlation. Conclusions : Psoriatic arthritis of TMJ has been found oftenly unilateral (oligo type). Female/ male ratio is about 1 : 1. nearly 50% of patients were having limitation in mouth opening. Most of the patients were having positive family history.The development of psoriatic arthritis in TMJ is related to the duration of the disease. Plaque psoriasis is the most associated type with the psoriatic arthritis in TMJ. Most of patients with psoriatic arthritis show psoriatic nail changes. The most radiographic findings found in patients with psoritic arthritis was erosion in the condylar head. There is association between clinical and radiologic findings for psoriatic arthritis in TMJ.

ضبط الحواف ومقاومة الكسر لاغلفة ال Ceramill Sintron المعدنية المصممة والمصنعة بالحاسوب مكسوة بثلاث انواع مختلفة من الخزف == Marginal Discrepancy And Fracture Resistance of CAD\CAM Ceramill Sintron Metal Copings With Different Porcelain Materials

اسم المؤلف: مصطفى نبيل عبد الغني
اسم المشرف: عمار عطا الله علي السعدي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: دقة الحواف والقوة، لاي ترميم معوض للاسنان هي صفة مهمة. ويمكن اعتبارعدم تطابق للحواف او قلة القوة سبب مهم يؤدي الى فشل التعويضات الاصطناعية للاسنان.لذلك تم اجراء هذا البحث لغرض تقييم اختلاف ظبط حافات ومقاومة الكسر لتيجان السيراميك المصنعة من اغلفة الC | Marginal fit and strength are important criteria for any restoration; poor marginal fit and low strength may be considered as a source of prosthesis failure. This study was performed to compare the marginal fit changes and facture resistance of metal ceramic crowns constructed from Ceramill Sintron metal coping veneered with three different porcelain veneering materials (Vita Master Koromikos VMK, Willi Geller Creation CC and GC initial MC). Also evaluating the influence of thermocycling on load at fracture value. The method included the use of master brass die which was milled to represent the prepared maxillary central incisor. Sixty metal copings were milled directly using Ceramill Sintron blank, then divided randomly into three groups. Each group consist of twenty metal copings, then veneered with porcelain : VITA for group A, Creation for group B and GC for group C. The marginal gap was measured before and after porcelain veneering for each group using travelling light microscope, then marginal fit changes was calculated. Fracture resistance test was done by Instron®, the master die was duplicated to sixty analogs then each analog was fixed into acrylic base. After that each crown was cemented onto the corresponding die analog using zinc phosphate cement. Ten samples of each group were subjected to compressive loading to fracture and other ten subjected to thermocycling followed by compressive loading to fracture.The result showed that GC group was highly significant different from other tested groups in marginal fit changes, whereas there was no significant different between VITA and Creation group. While there was significant difference among tested group at (P < 0.01) in fracture resistance, and the effect of thermocycling process did not significantly reduce the load at fracture for all groups.This study concluded that GC group present the least marginal fit changes, while the fracture resistance was highest for VITA group follow by Creation then GC. Thermocycling reduce load at fracture but not significantly.

A Comparative Study To Evaluate Canal Transportation And Centering Ratio At Different Levels of Simulated Curved Canals Prepared By Irace, Protaper NEXT And Protaper Universal Files == A Comparative Study To Evaluate Canal Transportation And Centering Ratio At Different Levels of Simulated Curved Canals Prepared By Irace, Protaper NEXT And Protaper Universal Files

اسم المؤلف: محمد علي فاضل
اسم المشرف: Hikmet A. Sh. Al | Gharrawi
الموضوع العام: طب الاسنان
السنة: 2015
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تحضير قناة الجذر يشمل كلا من تشكيل وتوسيع المساحة اللبية بالاضافة الى تطهيرها من الجراثيم، من دون اي خطا اجرائي هو من اقصى درجات التفضيل. حديثا، في مجال تطبيقات حشوات الجذور، ادوات النيكل تيتانيوم اصبحت تستخدم بصورة شائعة لتنظيف وتشكيل قناة الجذر. ادوات ا | Root canal preparation includes both shaping and enlargement of the endodontic space in conjunction with its disinfection, without any procedural error is of the utmost preference. Recently, in endodontic practice, the nickel - titanium instruments are used commonly for the preparation of the root canal space. Nickel - titanium instruments are much more flexible than stainless steel files and have superior cutting efficiency. Super - elasticity of nickel - titanium rotary instruments allows the clinicians to produce the desirable tapered root canal form with a reduced tendency to canal transportation and instrument fracture. The target of this study was to measure and compare the canal transportation and centering ability of iRaCe and ProTaper NEXT nickel titanium instruments with ProTaper Universal instruments in simulated curved canals at different levels and compare canal transportation and centering ability among different levels for each tested instrument.Sixty simulated curved canals of 40°curvature were randomly divided into three groups of twenty canals each; the first group (group A) was prepared with iRaCe instruments, the second group (group B) was prepared with ProTaper NEXT instruments and the third group (group C) was prepared with ProTaper Universal instruments. The canals were prepared to an apical size 30 by crown - down instrumentation technique. Removal of material was measured at five different levels : at the canal orifice (O), half way to the orifice in the straight sections (HO); the beginning of the curve (BC); the crest of the curve (AC); the end point (EP). Pre - and post - operative photos of the simulated canals were taken in a standardized technique at magnification of 40X. An assessment of canals shape has been determined using Photoshop CC 2014 and AutoCAD 2014 software program. The data of canal transportation as well as centering ratio were analyzed statistically using Shapiro - Wilk, ANOVA and LSD tests.Within the limitation of this study, it is shown that canals preparation with the three designs of NiTi instruments produced canal transportation. However, the iRaCe instruments showed a significantly less canal transportation and a significantly better centering ability than both ProTaper NEXT and ProTaper Universal instruments at all levels of measurements, followed by ProTaper NEXT instruments that showed a significantly less canal transportation and significantly better centering ability at all levels when compared with ProTaper Universal, while the ProTaper Universal instruments showed the highest values of canal transportation and the worst ability to stay centered in the canals at all levels. Considering the direction of canal transportation, the iRaCe instruments showed minimal transportation towards inner aspect of canal at coronal and at the apex of curve and towards outer aspect of canal at middle, beginning of curve and at the end point of the preparation, while ProTaper NEXT instruments were showed transportation usually towards the inner aspect of the canal at middle part of the canal and towards the outer aspect at coronal, beginning of curve, apex of curve and at the endpoint of the preparation, while ProTaper Universal files were usually towards the inner aspect at middle part of the canal and towards the outer aspect at coronal, beginning of curve, apex of curve and at the endpoint of the preparation.

الانتشار والعلاقة بين اضطرابات المفصل الصدغي بين طلاب طب الاسنان على اساس معايير التشخيص والاجهاد والاضطرابات الفموية == Prevalence And Correlations Between Temporomandibular Disorders In Dental Students Based On Diagnostic Criteria (DC/TMD) , Parafunctions And Psychoemotional Stress

اسم المؤلف: علا علي خلف
اسم المشرف: هاجر ابراهيم عبد الله
الموضوع العام: طب الاسنان
السنة: 2015
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اضطرابات المفصل الصدغي والاضطرابات الفموية يبدو انها مشكلة متكررة في المجتمعات الحديثة. ويرتبط الباثولوجيا السببية المفصل الصدغي الى العضلات، واقواس الاسنان، ودواعم الاسنان. وتشمل الاسباب الرئيسية على حد سواء العوامل الفيزيولوجية المرضية والنفسية وا | Bagkground : The temporomandibular disorders (TMD) and oral parafunctions seem to be a frequent problem in modern societies. The etiopathology of the temporomandibular joints is related to muscles, teeth arches, and periodontium. Their main causes involve both pathophysiological and psychosocial factors. In the literature, a significant impact of the psychoemotional factor is reported, comparable to the impact of other factors concerning physical health such as systemic diseases, malocclusions, loss of teeth, and traumas. Stress, fatigue, anxiety, depression, sleep disorders, and a fast pace of life affect negatively the human psyche.Aim of study : The aim of the study was to assess the prevalence of temporomandibular disorders (TMD) and oral parafunctions, as well as their correlation with psychoemotional factors among dental students by using diagnostic criteria (DC/TMD).Subjects, materials and methods : the sample’s size of 407 students (169 males and 238 females) of dental college (100 fifth stage , 102 fourth stage ,99 third stage and 106 second stage ). Firstly students subjected for stress questionnaire (perceived stress scale - 10) , secondly they subjected to different clinical and questionnaire measures according to diagnostic criteria of temporomandibular disorders DC/TMD (axis1) which have standerized series of diagnostic tests based on clinical signs and symptoms , finally the dental students subjected for oral parafunctions questionnaire using oral behavior checklist.Results : the results obtained from this study showed that the prevalence of TMDs was significantly greater among students with oral parafunctions. We also observed that the prevalence of TMDs according to DC/TMD was higher among students with headache.In this study, the prevalence of psycho - emotional stress , TMD according to DC/TMD and oral parafunctions were higher in females than males and in fifth stage greater than other stages.Conclusion : • the prevalence of TMDs according to DC/TMD were significantly higher among females than males.• Oral parafunctions ( bruxism , cheek/lips biting , objects biting and nail biting ) showed greater prevalence in fifth stages than others and higher in females than males • In all stages females showed greater prevalence of psycho - emotional stress than males and among students of fifth stage the prevalence of psycho - emotional stress was higher than other stages.

قوة الدفع الرابطة الى الخارج والتسرب القمي للمواد (MTA Plus, Biodentine and Bioceramic) بتقنية حشوة ثلث القمي للجذر : دراسة مختبرية == Push - Out Bond Strength And Apical Microleakage of (Mta Plus, Biodentine, And Bioceramic)As Apical Third Filling (An In Vitro Study)

اسم المؤلف: عبير علي عباس
اسم المشرف: جمال عزيز مهدي
الموضوع العام: طب الاسنان
السنة: 2015
الموضوع الدقيق: معالجة الاسنان
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت هده الدراسة المختبرية لتقيم قدرة ختم لثلاث مواد استعملت ( بتقنة حشوة ثلث القمي لقناة الجذر ) باستعمال اختبار قوة الربط الدفع الى الخارج ودراسة التسرب القمي.ستين جذر حلقي الاسنان العلوية ذو قناة مستقيمة ذات فتحة قمية مكتملة التكوين مختارة بعناية وفق | This study was conducted to evaluate the sealing ability of three materials used as apical third filling by using push - out bond strength test and apical microleakage study.Sixty straight palatal roots of freshly extracted maxillary first molars were selected. All teeth had mature apices, selected carefully according to specific criteria. The roots were instrumented using crown down technique with rotary Protaper universal system, instrumentation were done with 5ml of 2.5% sodium hypochlorite used as irrigation between files, 17% buffered solution of EDTA was used as final irrigant followed by 2.5% sodium hypochlorite then 10ml distilled water to remove any remnant of irrigant. Roots were randomly divided into three groups according to the filling materials used ( twenty roots for each group) : Group (1) : MTA Plus ( 4mm thickness) using as apical third filling. Group (2) : Biodentine (4mm thickness) using as apical third filling.Group (3) : Bioceramic root repair material (4mm thickness) using as apical third filling.Easy and Quick (E&Q) obturation system were used to complete obturation of roots. After incubation period at 37 °C for three days. Ten roots from each group were used for push - out test, after root were embedded in clear acrylic resin, sectioned at apical level in 2mm and 4mm from root apex to provide slice 2mm in thickness. The bond strength was measured using computerized universal testing machine, each section fixed in the machine so that the load applied from apical to coronal direction at 0.5mm/min speed and the computer drew curve to show the higher bond force before dislodgment of the filling material. These force were divided by surface area to obtain the bond strength in MPa.After debonding each sample was examined under Stereomicroscope and the type of failure mode was recorded. The result showed non significant different between Biodentine group and MTA Plus group. Biodentine group showed a very high significant difference with Bioceramic material group. Also high significant difference between MTA Plus group and Bioceramic material group. The Biodentine group showed highest mean of bond strength in comparison to other test group.Ten roots remain from each group used for apical microleakage study. The roots submerged in 2% methylene blue for three days. The roots were cleared and the degree of linear dye penetration was measured in millimeter by stereomicroscope under 40 X magnification with calibrated scale ocular grid. The result showed the Biodentine group lowest mean of microleakage than other group while Bioceramic material group showed high mean of microleakage than other groups. There are no significant difference among groups. There is positive correlation between push - out bond strength and an apical dye penetration in microleakage for each group of material.

فشل القشور الخزفية المصنوعه من السيراميك باستخدام تقنيات اللصق المختلفة : دراسة مقارنة مختبرية == Failures of Porcelain Laminate Veneers Using Different Techniques of Bonding (A Comparative In Vitro Study)

اسم المؤلف: صفا عدنان كعيد
اسم المشرف: عمار عطا الله علي السعدي
الموضوع العام: طب الاسنان
السنة: 2015
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Esthetic dentistry as a concept and adhesive materials development as a functional element make the new dawn of dentistry especially with the continuous development of adhesive techniques. This study is to evaluate the failure patterns of porcelain laminate veneers used to esthetically restore maxillary first premolar by bonding them to enamel and dentin with two different techniques.Forty eight extracted human maxillary first premolar were used for this study. Teeth were divided randomly into one control group and three experimental groups of twelve teeth eachGroup (A) were prepared in enamel (0.5 mm) depth of preparation. Group (B) were prepared in dentin (1 mm) depth of preparation and their veneers were bonded by DDS technique. Group (C) were prepared in dentin (1 mm) depth of preparation and their veneers were bonded by IDS technique. Standard preparation for each tooth in the experimental groups with ceramic veneer set burs especially designed for laminate veneer preparation. All the experimental groups were restored with the same type of veneer which was lithium disilicate ceramic CAD/CAM blocks (IPS e. max CAD, ivoclar vivadent) and were milled by CAD/CAM technology (CEREC inLab 4.02 milling system, Sirona).For all the experimental groups, Choice™2 veneer cement (Bisco, USA) was used for the luting of veneers. After cementation, teeth were stored in distilled water in 37°C for one week. The specimens were loaded to failure using instron universal testing machine. Specimens in experimental groups were examined by stereomicroscope at magnification of 20x to evaluate the mode of failure.Results were statistically analyzed and showed that the highest mean of failure load was recorded for the control group (548.1 N ± 93.2), for group (A) the mean of failure load was (393.4 N ± 84.2), and for Group (B) had the mean of failureAbstract IIIload was (237.8 N ± 91.6), and for group (C) the mean of failure load was (318 N ± 82.2).The one way ANOVA test was carried out and showed that there is a statistically high significant difference among the groups.Then the LSD test have shown that there is a statistically high significant difference between the control group and all three of the experimental groups, and there was a statistical high significant difference between group (A) and group (B), while group (C) have shown that there is a statistical significant difference with groups (A) and (B).The mode of failure varied from only debonding in groups (B and C) to deboning and fracture in group A.In conclusion, this study found that although enamel is still the most favorable tooth substrate for indirect adhesive restorations, the development of bonding techniques like IDS made dentin as acceptable tooth substrate for indirect adhesive restorations when it's unavoidable.

تقييم صحة الفم والبروتينات اللعابية لدى المرضى المصابين بمرض باركنسن == Assessment of The Oral Health And Saliva Proteins In Patients With Parkinsons Disease

اسم المؤلف: صباح فرحان مشتت
اسم المشرف: هاجر ابراهيم عبد الله | مروان صالح النمر
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Parkinson's disease (PD) is a progressive neurodegenerative disorder related to the loss or absence of dopaminergic neurons in the brain. The deficits caused by PD result in slowness of movement, tremor, rigidity, and dysfunction of behavior and these symptoms negatively influence the patient’s capability to carry out the daily oral hygiene manoeuvres.Aims of study : This study aims at using saliva as a biological fluid for assessment in detecting the biomarkers of Parkinson's disease and to assess the impact of this disease on the oral health of patients.Materials and methods : A total number of fourty participants were involved in the study; twenty subjects who appeared healthy (Group I) and twenty Parkinson's patients (Group II). Patients who are eligible for this study were cases of Parkinson's disease treated with anti - Parkinson's medications, both genders and their ages ranged from 40 - 75 years. Specific information related to the demographic characteristics and illness is obtained from each patient. The Brain Bank Diagnostic Criteria for Parkinson’s disease established by United Kingdom Parkinson's Disease Society was used. Each patient was subjected to oral examination during which DMF index was scored, oral health impact Profile OHIP - 14 was used and from each participant the whole unstimulated saliva was collected for biochemical analysis including total salivary protein, direct determination of saliva proteins and determination of ? - synuclein. Results : many oral and clinical signs and symptoms elsewhere in the body were reported in the patient with Parkinson's disease while the clinical features of Parkinson's disease observed in all patients despite of their treatment. Static tremor observed in 100%, rigidity in 70%, disturbances in the autonomic nervous system reflected on the cardiovascular, gastrointestinal and urinary tracts, orthostatic dizziness observed in 75%, dry mouth in 65% difficulties in swallowing in 40% and constipation in 70%. Teeth examination revealed that Parkinson's patients have a non - significant high means of decay and missing teeth compared with healthy subjects. The total saliva protein in Parkinson's patients is significantly higher than the corresponding value of healthy subjects. The extinction coefficient of uncontaminated protein in Parkinson's patients is significantly less than the corresponding values of healthy subjects and salivary ? - synuclein level is significantly less in Parkinson's patients than healthy subjects.Conclusions : Salivary ? - synuclein may serves as a biomarker for Parkinson's disease. Specific protein with extinction coefficient 27.5 M.Cm - 1 is secreted in saliva of Parkinson's patients. The characteristic saliva protein produced in patients with Parkinson's disease is deficient in tyrosine level and Dental care is required for both groups (Parkinson's patients and healthy subjects).

الاستريتين الفموي مقابل غلوكونات الزنك عن طريق الفم : دراسة علاجية مقارنة وعبورية في علاج مرض بهجت == Oral Acitretin Versus Oral Zinc Gluconate As A Comparative Cross - Over Therapeutic Study In Treatment of Behcet,S Disease

اسم المؤلف: سناء عبد الحميد حسين
اسم المشرف: هاجر ابراهيم عبد الله | عادل عبد الغفور النعيمي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اساس البحث : مرض بهجت هو اضطراب جهازي حيث ان اسبابه المرضيه ليست محدده جيده.المظاهر الاكثر شيوعا هي الاغشيه المخاطيه الجلديه ولكن يمكن ان يشمل العين, انظمة القلب,الاوعيه الدمويه والجهاز العصبي. هناك العديد من طرائق المعالجه الموضعيه والجهازيه. تمت محاول | Background : Behcet’s disease is a systemic disorder where its etiopathogenesis is not well determined. The commonest manifestations are muccocutaneous but can involve eye, cardiovascular and neurological systems. There are many modalities of therapy topical and systemic.Isotretinion has been tried as an effective therapy of muccocutaneous manifestations. In present work was to try a new retinoid like acitretin which has longer half life than isotretinoin.Aims of the study : To evaluate the effectiveness of oral acitretin versus oral zinc gluconate in the treatment and prophylaxis of Behcet’s disease as a new therapeutic model.Materials and methods : This cross over controlled therapeutic study that conducted in the Department of Dermatology - Baghdad Teaching Hospital the period from August 2013 - May 2014.Twenty patients with fulfilled criteria of Behcets’s disease was included in this work. History and full examination were done for all patients regarding all demo - garaphic points related to the disease. They were given acitretin 25 mg orally once daily for three months to be seen on the day fourteenth firstly and then monthly to be assessed depending on the clinical manifestation index for Behcets disease. After three months, acitretin was stopped and patients were given zinc gluconate 25 mg twice daily for another three months. Results : Twenty patients were treated 12 males (60%), and 8 females (40%), with male to female ratio 1.5 : 1. All these patients completed the study and their ages ranged between 20 - 59 years with mean± SD (37.3±12.3). Pathergy both ordinary and oral were also minimized by this therapy while C - reactive protein was not much effective by this therapy. Zinc gluconate also had the same therapeutic action against these manifestations. Clinical manifestations index before treatment ranged between 1 and 11 with mean ± SD of 5.65±1.98.After acitretin therapy the mean of CMI started to decline to reach 2.65 ±2.03 in first month of the therapy with (p=0.00001) which was statistically high significant and continued high significant till the end of the third month with (p - value > 0.000001). After cessation of acitretin and zinc gluconate started the mean continued to decrease to reach 2.05±2.52 at the end of the first month with (p=<0.000001) which was statistically high significant then; started to increase to reach 3.3 ±2.31 at the end of six month of the therapy but statistically remained high significant (p - value=0.0007). Both acitretin and zinc gluconate have statistically significant effect in reducing severity and frequency of oral ulcers, genital ulcers, skin and rheumatologic manifestations. Conclusions : oral acitretin was found to be an effective therapy in addition to its prophylactic action in treatment of muccocutaneous manifestations of Behcet,s disease. Also zinc gluconate had effective therapeutic action against these features of Behcet’s disease.

تاثــير مستوى الاسترادايول والبروجستيرون في اللعاب على حالة صحة الفم عند النساء اثناء الحمل == Effects of Salivary Level of Estradiol And Progesterone On Oral Health Status In Women During Pregnancy

اسم المؤلف: زينة كامل كاظم
اسم المشرف: هاجر ابراهيم عبد الله
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الحمل هو حالة فسيولوجية تجلب مجموعة واسعة من التغييرات في حياة المراة، بما في ذلك التعرض لامراض اللثة، ربما بسبب التغيرات الهرمونية المرتبطة مع الحمل. قد تؤثر الهرمونات الجنسية على اغشية الفم واللثة وربما هذا يؤدي الى العديد من الامراض اللثوية. ان هرمونا | Pregnancy is a physiological state that brings a wide range of changes in a woman’s life, including a susceptibility to gingival disease, probably due to hormonal changes associated with pregnancy. These female sex hormones may modify the oral mucosa and may lead to various degrees of gingival inflammation. The hormonal changes occurring during pregnancy may be associated with pregnancy gingivitis and gingival bleeding. Sex hormones are specific regulatory molecules have long been considered to play an influential role on periodontal tissues especially gingiva, bone turnover rate, wound healing and periodontal disease progression. Aims of the study1. Assessment of oral hygiene level and dental status in both second and third trimester pregnant women and compares results.2. Assessment salivary hormonal levels of endogenous female sex steroids in both second and third trimester pregnant women and compares results.3. Comparison of oral health status and endogenous female sex steroids salivary hormonal levels between gingivitis and non - gingivitis subgroups of both second and third trimester pregnant women groups.4. Find out the association between the gingival health status and salivary hormonal levels of endogenous female sex steroids (Estradiol and progesterone).Materials and methods This study was carried out on seventy - eight pregnant women who were attended for routine and regular follow up visits in obstetrics and gynecology department at Al - Yarmouk Teaching Hospital, from February 2013 to July 2013. This study was approved by the scientific committee in the department of oral medicine college of dentistry Al - Mustansiriya University. They were divided according to gestational age in to second trimester group and third trimester group. Fifty pregnant women (age range 18 - 38 years) and at gestational age was ranged between (20 - 27 weeks) were recruited as 2nd trimester group and Twenty - eight pregnant women (age range 18 - 39 years) at gestational age ranged between (28 - 33 weeks) were recruited as 3rd trimester group and according to Loe and Silness gingival index these two groups subdivided into gingivitis and non - gingivitis groups. Oral clinical examination including an assessment of gingival inflammation (Loe and Silness Gingival Index), Plaque amount (Silness and Loe Plaque Index), dental status (Decayed Missing Filling Teeth), and salivary flow rate (SFR) had also been done. Samples of whole unstimulated (resting) saliva were collected from all participants then investigated for sex steroids salivary hormonal levels of Estradiol, Progesterone. Results and discussion Oral health measurements including : GI, PLI, SFR and DMFT showed no significant difference between 2nd trimester and 3rd trimester groups. Sex steroids salivary hormonal levels of Progesterone showed a significant difference with higher mean value in 3rd trimester pregnant women than 2nd trimester pregnant women while sex steroids salivary hormonal levels of Estradiol showed no significant difference between two groups. Comparisons between gingivitis and non - gingivitis subgroups of 2nd trimester pregnant women group showed that there was highly significant difference in SFR with higher mean value in non - gingivitis group, and there was highly significant difference in PLI with higher mean value in gingivitis group, DMFT showed non - significant difference between the subgroups and (Estradiol and progesterone) salivary hormonal levels showed highly significant difference with higher mean values in gingivitis group. Comparisons between gingivitis and non - gingivitis subgroups of 3rd trimester pregnant women group showed that there was a non - significant difference in SFR, DMFT and a highly significant difference in PLI with higher mean value in gingivitis group, while progesterone salivary hormonal levels showed non - significant difference and Estradiol salivary hormonal levels showed a highly significant difference with higher mean value in gingivitis group. Comparison of GI between gingivitis groups of both 2nd and 3rd trimester pregnant women showed that there was a significant difference with higher mean value in 3rd trimester. Estradiol and progesterone salivary hormonal levels were non - significantly correlated with PLI and GI for gingivitis and non - gingivitis group of 2nd trimester pregnant women. Progesterone salivary hormonal level was non - significantly correlated with PLI and GI for gingivitis and non - gingivitis group of 3rd trimester pregnant women while Estradiol salivary hormonal level was non - significantly correlated with PLI and GI for non - gingivitis group and significantly correlated with PLI and GI for gingivitis group. GI and PLI for gingivitis groups of both 2nd and 3rd trimester revealed that there was a highly significant correlation.Conclusions Female Sex steroids hormones (Estradiol and Progesterone) salivary hormonal levels significantly increase from the second to the third trimester especially Estradiol and Play an important role in influencing gingival inflammation during pregnancy. These hormones are neither necessary nor sufficient to produce gingival changes by themselves. However, they may alter periodontal tissue responses to microbial plaque and thus indirectly contribute to gingivitis. Dental status in pregnant women is not significantly different between 2nd and 3rd trimester pregnant women groups. Women should be offered training in good oral hygiene habits, and community awareness programs should be conducted to increase their awareness of the crucial importance of such habits especially during pregnancy

قياس قوة الدفع للخارج لحشوات الجذور GuttaFlow 2 , Thermafil وGuttaCore : دراسة مختبرية == Push Out Bond Strength of Guttaflow 2, Thermafil, And Guttacore Obturation Materials (An In Vitro Study)

اسم المؤلف: حيدر طالب فاضل
اسم المشرف: جمال عزيز مهدي
الموضوع العام: طب الاسنان
السنة: 2015
الموضوع الدقيق: معالجة الاسنان
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت هذه الدراسه المختبرية لقياس قوة ارتباط لثلاثه مواد مختلفة لحشوات قنوات الجذور باستخدام قوة الدفع للخارج.ثلاثون جذر حلقي مستقيم من الاسنان العلوية الخلفية استخدمت في هذه الدراسه وهذه الاسنان تم تحضيرها بتقنيه التاج السفلي باستخدام نظام المبارد الد | This in vitro study was carried out to investigate the push out bond strength of three different obturation materials GuttaFlow 2, Thermafil and GuttaCore at different levels.Thirty extracted upper molars were collected and the platal roots were sectioned at the CEJ of the tooth. The platal roots were instrumented with Hyflex CM rotary files to the size of 40/0.06.The instrumented samples were divided into three groups of ten samples each, the first group were obturated with GuttaFlow 2, the second group were obturated with Thermafil and the third group were obturated with GuttaCore obturating materials.After an incubation period of 7 days, each sample were sectioned into three sections of 2 mm thickness (apical, middle, coronal), each slice then introduced to the push out testing using a universal testing machine at a cross head speed of 0.5 mm/min. The result of this study showed Push - out bond strengths were significantly higher when canals were filled with GuttaCore than those filled with Thermafil and GuttaFlow 2. And Thermafil showed a higher significant difference than the GuttaFlow 2. It also showed that the bond strength values decreased from the coronal to the apical direction.In conclusion, the thermoplasticized gutta - percha appears to achieve higher push out bond strength values than the cold flowable gutta - percha. With GuttaCore showed higher push out bond values than Thermafil.

التاثيرات الدوائية لمادة - كاپا كراجينان - في مهنية طب الاسنان : دراسات داخل وخارج الانبوب == The Pharmacological Effects of Kappa Carrageenan In Dental Practice : An In Vitro And In Vivo Studies

اسم المؤلف: اسيل جاسم علي
اسم المشرف: هاجر ابراهيم عبد الله | مروان صالح النمر
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: كاراجينان هومركب يحتوي على پولي كلايكان الكبريتي وهو مستخلص من الطحلب الاحمر. الكراجين بطبيعته الغروية المائية يمتلك خواص هلامية,مثخنة ومستحلبة تسمح باستخدامه بكثرة في الصناعات الغذائية,مستحضرات الصحة الفموية والكماليات.وبسبب مركباته الحياتية الفعالة فقد

Evaluation of the Involvement of the Tempromandibular Joint in Patients with Osteoarthritis and the Accuracy of Ultrasonography as Compared to Computed tomography for Detection of Osteoarthritic Changes.

اسم المؤلف: احمد عادل عثمان
اسم المشرف: هاجر ابراهيم عبد الله
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: خلفية البحث : اضطرابات المفصل الفكي الصدغي تشير الى مصطلح مركب يحتوي على عدة حالات تتضمن المفصل الصدغي ,التركيبات المحيطة او كلاهما , تظهر على شكل الم في منطقة المفصل والعضلات المرتبطة,وتحدد بالقدرة على الحركة الطبيعية مثل المضغ, الكلام والبلع. مرض التهاب | Tempromandibular joint disorders is a collective term embracing a number of conditions affecting the TMJ, the surrounding structures or both,manifested by pain in the area of joint and associated muscles, and limitation in the ability to make normal movement like mastication,speech and swallowing. Osteoarthritis is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. A variety of causes—hereditary, developmental, metabolic, and mechanical deficits may initiate processes leading to loss of cartilage. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may undergo atrophy, and ligaments may become more lax.Objective of the study : • To determine the extent of tempromandibular joint involvement in patients with osteoarthritis.• To evaluate the correlation between clinical and radiographical findings. • To evaluate the accuracy of sonography in detection of osteoarthritic changes compared to Computed tomography.Materials and method : A comparative study had been done using thirty six symptomatic patients(24 female and 12 male) above 40 years diagnosed as osteoarthritis by specialist rheumatologist in Alkarkh general hospital, with clinical finding related to osteoarthritis like pain,tenderness,crepitation, clicking and limited mouth opening. these patients were exposed to computed tomography(CT) scan (Philips - Brilliance 64) in Al - Karkh general hospital and then the results were compared with sonographic findings (Philips 12.5 MHz transducer) to see the disc displacement, effusion, erosion, flattening, osteolytic and osteophytic lesions in the condylar head.The period of the study started from (october - 2013 to june - 2014).Results : The result of the study showed that the mean age of osteoarthritic patients was (49.69) years, and female percentage (66.7%) and male(33.3%). Chief complaine showed more predilection in the left side (28%) and bilateral showed(56%).Clinically : limitation in mouth opening (50%),crepitation(36.11%), clicking (27.7%), and tenderness (20.8%). Radiographically Computed tomography(CT) scan showed disc displacement (50%), joint effusion (37.5%), flattening(36.11%), osteophyte(18,05%), and erosion(11.1%). There was significant correlation between clicking and joint effusion in computed tomography(CT),while tenderness showed significant correlation with osteophyte and joint effusion in sonography. Other correlations were non significant correlation between clinical and radiological changes. Association between computed tomography(CT) and sonography showed fair agreement in osteophyte detection,fair agreement in joint effusion,moderate agreement in detection of joint erosion,moderate agreement in reduction of space and anterior disc displacement and also moderate agreement in condylar head flattening. Conclusions : Osteoarthritis in tempromandibular joint may be unilateral or bilateral. About 50% of Patients with osteoarthritis have limitation in mouth opening. Clinical findings play a major role in diagnosis of osteoarthritis. The tempromandibular joint changes in osteoarthritis were the results of degenerative processes, in contrast to rheumatoid arthritis were the changes as a result of the disease. Sonography was more likely to be sensitive rather than specific in detection of osteoarthritic changes

حدوث وشدة الالم بعد استخدام ثلاثة انظمة مختلفة لتحضير قنوات الجذور == Incidence And Severity of Pain Following The Usage of Three Different Root Canal Instrumentation Systems

اسم المؤلف: احمد حمد عبيد
اسم المشرف: جمال عزيز مهدي
الموضوع العام: طب الاسنان
السنة: 2014
الموضوع الدقيق: معالجة الاسنان
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Postoperative pain after endodontic procedures is an undesirable occurrence for both patients and clinicians. Certain factors may predispose to the development of postoperative pain. Knowledge of the causes and mechanisms behind interappointment pain in endodontics is of utmost importance for the clinician to properly prevent or manage this undesirable condition. The causative factors of interappointment pain encompass mechanical, chemical, and microbial injuries to the pulp or periradicular tissues, which are induced or exacerbated during root canal treatment. Ninety patients were recruited and included in this study out of one hundred and twenty patients, those patients requiring endodontic treatment on their permanent upper or lower molar teeth with asymptomatic irreversible pulpitis preoperatively, access opening and instrumentation was performed at the same visit.Patients ranged in age from 19 to 50 years old, and all were in good health, as determined from a written health history and oral interview.The patients were assigned randomly into three groups of 30 patients each : ? First group (n=30) : Teeth were instrumented using Universal ProTaper System (Full Rotary technique).? Second group (n=30) : Teeth were instrumented using ProTaper Next System (Full Rotary technique).? Third group (n=30) : Teeth were instrumented using WaveOne System (Reciprocating technique).Pain assessment carried out at day 1, 2, 3 & 7 using Verbal Rating Scale (4 - Point Scale). Patients recorded the incidence and severity of pain experienced.Patients were called at 24, 48 and 72 hours to obtain their reports for the first three days. Seven days after treatment their records were reviewed and percussion test was performed. Result showed that all groups induced Post - operative Pain, the difference is some systems cause more Post - Operative pain than other do : group 3 (WaveOne group) showed higher incidence and severity of PostoperativePain, followed by group 1 (Universal ProTaper group) that has shown less incidence and severity of Post - operative Pain than group 3 (WaveOne group), last group which it was group 2 (ProTaper Next group) has shown the lowest incidence and severity of Post - operative Pain. The data obtained were analyzed statistically using Chi Square test, total score for Verbal Rating Scale at day 1, 2, 3, and 7 showed that there was a highly significant differences between ProTaper Next group and other twogroups (P ? 0.001), and non - significant differences between ProTaper group and WaveOne group (P ? 0.05).

مستخلصات الشاي تاثيرها الذاتي او الاضافي على حياة خلايا السرطان : دراسة داخل وخارج الانبوب == Herbal Tea : Its Own Or Additive Effect On The Survival Of Cancer Cell Line : An In Vitro And Ex Vivo Study

اسم المؤلف: هدى غسان حميد
اسم المشرف: مروان صالح النمر | ناهي يوسف ياسين
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت هذه الدراسة في فرع الفارماكولوجي في كلية الطب في الجامعة المستنصرية بالتعاون مع مركز ابحاث السرطان والوراثة\الجامعةالمستنصرية خلال الفترة من شهر كانون الثاني - شهراب لسنة 2014. الدراسة اقرت من قبل مجلس كلية الطب. صممت هذه الدراسة لتوضيح فعالية نبات ا | This study was conducted in the Department of Pharmacology at College of Medicine with incorporation of the Iraqi Center for Cancer and Medical Genetic Research at Al - Mustansiriya University, Baghdad, Iraq during 2014. This study was designed to elucidate the anti - cancer effect of Camellia sinensis by using four types of tea (black, green, white and oolong). Two experimental cancer models applied in this study; cancer cell lines (In vitro) and mice - bearing tumor (ex vivo). Several methodological and extracted aqueous and organic solvents were used to extract the tea. Microwave assisted extraction using distilled water as a solvent is applied in this study as the yield of bioactive substances are higher than other methods and organic solvents. The antioxidant activity was evaluated through the quantification of total flavonoids, total polyphenolic compound (bioflavanoids), total flavonols, reducing power, and proanthocyanidines. The scavenging property against reactive nitrogen species also was studied. The result showed that the different tea types contain approximately the same quantity of phenolic compounds; the only significant difference was in the proanthocyanidins level, which is a class of flavanols, found in high quantity in green tea compared with other tea extracts. Moreover, a significant scavenging property of peroxynitrite radical observed with all tea extracts. The extracts of black, green and oolong tea prevented or halted nitric oxide generation whereas the white extract tea promoted its generation, that is, a nitric oxide donor. The in vitro cytotoxic activity of Camellia sinensis in form of black, green, white and oolong tea was evaluated against four different types of cell lines. These are the AMN3 mammary cell carcinoma, Rhabdomyosarcoma, HeLa cells and Rat embryo fibroblast cells). The results showed greater effect of green and black tea over white tea and oolong tea against mammary cell carcinoma while the results of rhabdomyosarcoma cell line, which is an aggressive cancer cell, revealed a significant inhibitory effect of the growth of these cells by white and oolong tea extracts. All four types show almost equal percent of growth inhibition on HeLa cell line with the white tea been the most significant. A significant inhibitory effect of all tea extracts against the growth of rat embryo fibroblast cells indicated that the cytotoxic effect of the Camellia sinensis extended to normal cells and not specific to cancer cell. In addition, the antitumor effect of tea extracts was investigated (ex vivo) on BALB - c mice bearing - tumor. The volume, shape and color of the tumor masses were examined, in addition to measurement of the tissue malondialdehyde level as a biomarker of the lipid peroxidation, total tumor protein measurement and a histopathological study were done. The white tea showed antitumor effect by attenuating all the biomarkers of tumorogenesis. Herbal tea extracts induced DNA damage in term of separation the double strands molecule of calf thymus double stands DNA and human genomic DNA which may partly explained anti - cancer effect. We concluded that white tea extract is a promising nutrient that ameliorates the histopathological changes in mice bearing mammary tumor via generation reactive oxygen species by the evidence of activation lipid peroxidation process. Camellia sinensis plant can induce non harmful effect on DNA

تاثير كل من عقار الروزوفاستاتين وعقار الاتورفاستاتين على مؤشرات نسب السكر المصاحبة للسمنة المحدثة في الفئران == Effects Of Atorvastatin Versus Rosuvastatin On Glycaemic Indices In Diet Induced Obese Mice

اسم المؤلف: نورس لطيف وهاب
اسم المشرف: علي اسماعيل عبد الله محمد | حيدر مطير القريشي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Numerous interventional cardiovascular disease outcome studies have resulted in statins being an essential factor of cardiovascular primary and secondary prevention strategies.In recent years there was ahigh concern that statin use is associated with diabetes new onset which is strong, independent risk factor for cardiovascular (CV) and cerebrovascular outcomes ,several studies resulted in conflicting results regarding different statin types & dose effect on glycemic control. Atorvastatin which is the most widely used statin worldwide and rosuvastatin the most efficacious ;they have different structural characteristics that have been speculated to have influence on diabetes onset.Aim of the study : The present study aims at investigating the effect of different doses of atorvastatin and rosuvastatin on glycaemic indices and metabolic disorders on mice model of diet induced obesity. Materials and method : The animals were divided into two groups : one served as control that received normal regular chow & the other group received high fat diet for the whole 12 weeks of experiment.After eight weeks of HFD feeding ;group (2) farther subdivided into five groups(12 mice in each) ; the first group received HFD only ,the second group received single daily dose / po of 20mg /kg rosuvastatin ,the third group received single daily dose / po of 40mg /kg rosuvastatin ,the fourth group received single daily dose / po of 20mg /kg atorvastatin ,and the fifth group received single daily dose / po of 40mg /kg atorvastatin for the last four weeks of experiment.Body weight ,food intake, lipid profile ,glycaemic indices were taken at baseline ,before treatment and after treatment.At the end of experiment ,animals were sacrificed , plasma & tissue sample were collected for biochemical analysis and histological observations.Results : Results of the present study shows that high fat diet feeding resulted in obesity development and metabolic abnormality like; hyperglycemia ,hyperinsulinemia ,insulin resistance , dyslipidemia and moderate to severe hepatic steatohepetitis compared to control group. and treatment resulted in significant improvement in lipid profile ,reduction in food intake ,body weight ,also associated with improvement in insulin sensitivity , hepatic steatohepetitis and reduction in insulin secretion.twenty mg/kg dose of atorvastatin showed better influence on glycaemic indices and comparable influence on hepatic picture over fourty mg/kg does while twenty mg/kg dose of rosuvastatin resulted in deterioration of glycaemic indices and no apparent improvement in hepatic steatosis. Unlike group that received 40 mg /kg rosuvastatin which showed significant improvement in all related metabolic disorders. Conclusion : Feeding mice with high calories diet for 2 month result in induction of obesity and disturbance of metabolic parameters. Treatment with rosuvastatin or atorvastatin has good impact on bodyweight , metabolic derangements &hepatic steatosis in obese mice. Both drugs seems to improve lipid profile in dose dependent manner, however their effects on glycaemic indices has different attitude. It is seems that rosuvastatin, especially at high dose, has better impact on glycaemic indices than atorvastatin and this might attributed to the difference in their pharmacokinetic properties

التقييم الفسلجي للاعتلال العصبي الذاتي لمرضى داء السكري

اسم المؤلف: نسرين قادر كامل
اسم المشرف: محمد شريف عبد الله | موسى محمود مربط
الموضوع العام: الطب
السنة: 2004
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Autouomic neuropaty
  • diabetics mellitus
  • heart rate
  • blood pressure
  • E C G
  • cardiovascular reflex
الصفحات الاولى:
المستخلص: (Diabetes Mellitus) D.M : - is the most common endocrine disease, characterized by abnormalities of glucose, protein and lipid metabolism. Diabetic neuropathy is one of the long term chronic complications, which contributes to increase the morbidity & mortality rate in diabetes. One of the earliest manifestations of diabetic autonomic neuropathy is denervation of the cardiovascular system, assessment of cardiovascular reflexes affords a satisfactory evaluation. Along duration time.A battery of bedside clinical tests was used to assess the autonomic function of the heart. This is the response of blood pressure to sustained handgrip and standing - up. The R - R interval change and Q - T interval change in the E, C G in response to standing - up, deep breathing and valsalva maneuver. Number of the patients was 40 diabetic subject and 22 age and sex matched healthy controls. Insulin dependent diabetes Mellitus (IDDM) was 25(62.50%) of cases, non insulin dependent Diabetes Mellitus (NIDDM) was 15(37.5%) of cases, autonomic neuropathy was detected in 23 patients (57.5%), Orthostatic hypertension in 19 cases (47.5 %), abnormal blood pressure response to sustained hand grip in 20 (50%), abnormal valsalva ratio in 10 (25%), abnormal heart rate response to deep breathing in 11 cases (27.2%).Among the 13 patients with cardiac diabetic autonomic neuropathy, had a Q - Tc interval of > 440 ms ( p < 0.05 ). Compared to the remaining 4 patients had normal Q - Tc interval of 399.5 ± 37.49ms.Cardiovascular tests for cardiac autonomic neuropathy showed increase prevalence with increase in the duration of Diabetes Mellitus above 15 years.This study showed that diabetics had significantly impaired cardio - autonomic reflexes compared to non diabetics. Also, other group of diabetics who have apparently normal cardio - autonomic reflexes were found to have significantly different values compared to the control group, (heart rate variations with deep breathing and valsalva maneuver had a negative correlation with age)

تاثير استخدام عقار الميتفورمين منفردا او مع عقار السيتاكلبتين على مستويات الاومنتين - 1 لدى مرضى داء السكري من النوع الثاني == Effects Of Metformin Alone Or In Combination With Sitagliptin On Serum Omentin - 1 Levels In Patients With Type - 2 Diabetes Mellitus

اسم المؤلف: ميقات طالب حمادة
اسم المشرف: حيدر مطير خليل القريشي | عبد الكريم يحيى السامرائي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الخلفية : داء السكري يشير الى مجموعة من امراض الايض مع ارتفاع مستوى سكر الدم. يمثل النوع الثاني من داء السكري ما نسبته 90 - 95% من جميع حالات السكري. يمثل النقص في الانسولين ومقاومة الانسولين وغيرها من الاضطرابات الهرمونية المشاكل الاساسية لمرضى السكري من ال | Background : Diabetes mellitus (DM) describes chronic metabolic disorders with hyperglycemia. Type II DM (T2DM) represents for approximately 90 - 95% of all diabetic types. A combination of insulin deficiency, insulin resistance and other hormonal irregularities are key problems with T2DM. Adipose tissue can be classified into two types : the brown and white adipose tissues. The white type is considered an important secretory organ which produces many bioactive molecules, collectively termed adipokines. Recently, a new adipokine named omentin - 1, has been identified and it was found that individuals with impairment in glucose homeostasis and newly diagnosed T2DM showed a lower serum omentin - 1 level. However, the effects of antidiabetes drugs on serum omentin - 1 level had not been studied extensively.Objective : The current study was design to measure serum omentin - 1 in T2DM as comparing with control subjects, also to study the effect of three months therapy with metformin and/or sitagliptin (when added to ongoing metformin therapy) on serum omentin - 1 levels in addition to other parameters.Method : This study was carried out on thirty healthy control subjects, and sixty three T2DM patients. The patients enrolled in the current study were divided into two groups. First group : included thirty one of newly diagnosed T2DM patients, started treatment with metformin. Second group : included thirty two patients with T2DM, already on ongoing metformin therapy and started treatment with sitagliptin. All patients received their treatment for three months duration, and blood samples were collected from them at the beginning of the study and after three months of starting treatment to measure the possible change in the studied parameters which include : fasting blood glucose (FBG), postprandial blood glucose (PBG), Glycosylated haemoglobin (HbA1c), serum level of insulin, insulin resistance (IR), serum omentin - 1 levels, lipid profile, body mass index (BMI) as well as blood pressure. Results : The results showed that baseline level of serum omentin - 1 in the newly diagnosed T2DM was significantly lower than matched control subjects. The level of omentin - 1 was significantly reduced after three months duration of treatment in sitagliptin group with no significant change in metformin group. FBG, HbA1c and PBG were decreased significantly after three months in metformin group, while in sitagliptin group, only HbA1c and PBG were decreased significantly after three months. In both groups, and after three months duration of treatment, there were no significant changes in serum level of insulin, IR, TG, VLDL - C, HDL - C, BMI, and blood pressure.Conclusion : In newly diagnosed patients with T2DM, serum omentin - 1 was reduced compared to age and BMI matched healthy subjects. Three months treatment with sitagliptin resulted in a significant reduction in omentin - 1 levels compared with baseline values. However, three months treatment with metformin had no significant effect on serum omentin - 1 level compared with pre - treatment value

تاثير استخدام عقار الكلورال هيدريت منفردا او استعماله مجتمعا مع عقار الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال == Chloral Hydrate Alone Or In Combination With Diazepam As A Sedative For Auditory Brainstem Response Testing In A Pediatric

اسم المؤلف: مريم محمد حميد مصطفى
اسم المشرف: حيدر مطير خليل القريشي | حيدر وهاب السرحان
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لبحث تاثير استخدام الكلورال هيدريت منفردا او استعماله مع الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال من اجل تقييم ما اذا كان اضافة الديازيبام له تاثير ايجابي او سلبي.اعتمدت الدراسة الحاليه على160 متطوعا من الاطفال ال | Background : children usually need sedation for diagnostic and therapeutic interventions. It is well known that pediatrics age groups are at higher risk for sedation - related complications than adults. Auditory brainstem response testing is one of the important diagnostic procedure that usually need sedation in order to preformed in children. Chloral hydrate is a hypnotic agent used since 1832 with low incidence of adverse events; whoever, despite the world wide use it is being abandoned due to bitter test, long time of sedation onset, vomiting and mild sedation. Rectally diazepam, on the other hand, produces higher and fast concentration in CSF with greater rate of success but probably with higher adverse events. Aim of the study : were to compare the sedative effect of chloral hydrate with chloral hydrate diazepam combination as well as their related adverse effects in children underwentg auditory brainstem response testing. Methods : in this randomized clinical study, 160 child underwent sedation for auditory brainstem response test participated. They were divided equally and randomly into 4 groups. Group A : Received 20 mg/Kg oral chloral hydrate as sedative, Group B : Received 20 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally, Group C : Received 40 mg/Kg oral chloral hydrate as sedative, and Group D : Received 40 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally. At the beginning, blood pressure, respiratory rates, peripheral oxygen saturation recorded, and then re - recorded immediately after drug administration and at (3, 5, 10, 20, …. min). Ramsay sedation scale used for assessment of the sedation level which measured every 10 min. Results : This study shown the beneficial use of chloral hydrate in combination with diazepam as sedation in ABR test (in groups D) by increased in the sedated number (p<0.05), decreased in the requirement of chloral hydrate re - dose, increased in the number of children whom completed ABR test (p<0.05) without significant differences on side effects or vital signs compared with the others three groups. 4.3. Conclusion : From this study we concluded that : • Used of oral chloral hydrate in dose (20mg/kg) alone not sufficient as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (20mg/kg) in combination with rectal diazepam (0.5 mg/kg) better than used it alone as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (40mg/kg) in combination with rectal diazepam (0.5 mg/kg) was the best sedative in paediatrics for ABR test. • Used of Chloral hydrate diazepam combination in ABR test of paediatrics increased the number of the sedated children, decreased the requirement of chloral hydrate re - dose, and increased the number of completed ABR test, with less complication

تاثيرات استخدام عقار الفيراباميل وعقار السايكلوسبورين في حالة اعتلال عضلة القلب الناتج من استخدام عقار الدوكسوروبسين : في الفئران المختبرية == Effects Of Verapamil,Labetalol And Cyclosporine Use In The Condition Of Cardiotoxicity Resulted From Doxorubicin Use : Animal Model Study

اسم المؤلف: محـمد عبد العزيز محـمد
اسم المشرف: حيدر مطير خليل القريشي | خالد جمعة خليل
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Doxorubicin is a member of anthracycline antibiotic that widely used in the treatment of different types of cancer such as hematological malignances, solid tumors, and different organ tumors, doxorubicin is very efficient in the treatment of cancer. But the use of doxorubicin is limited by the side effect of doxorubicin on the same organ, the most important organ that affected by doxorubicin is the heart, the toxicity of doxorubicin in the heart, the use of doxorubicin due to the cardiotoxicity that induced by doxorubicin will lead to cardiomyopathy and in the final result of these cardiotoxicity lead to congestive heart failure that occurred secondary to the cardiotoxicity may appear after long period of termination of treatment by doxorubicin.ObjectivesThe aim of the present study its investigate the possible modulation effect of drugs (verapamil, cyclosporine, labetalol) on the cardiotoxicity that induced by doxorubicin drug. Animals and methods forty Dwale - Spargue male rats where enrolled in this study, the animals divided into groups, (5) rats in each group and assigned as I,II,III,IV,V,VI,VII,VIII.Group I : received physiological saline (5ml/kg), orally, daily for ten days and served as the control.Group II : received a single dose of doxorubicin (15mg/kg), intraperitoneal and was sacrificed after 48 hours which served as doxorubicin group.Group III : received verapamil (5mg/kg), orally daily for ten days and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg), intraperitoneal were given.Group IV : received cyclosporine (0.5mg/kg), orally daily for ten days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg, intraperitoneal) was given.Group V : received cyclosporine (1mg/kg), orally daily for ten days ,and on day eight ,one hour after drug administration a single dose of doxorubicin (15mg/kg),intraperitoneal was given. Group VI : received both of verapamil (5mg/kg,orally) and cyclosporine (0.5mg/kg,orally) one hour apart, daily for ten days ,and on day eight, one hour after drug administration ,a single dose of doxorubicin (15mg/kg), intraperitoneal was given.Group VII : received labetalol (0.5mg/kg), orally daily for ten days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg, intraperitoneal) was given. Group VIII : received labetalol (1mg/kg, orally),daily for ten days ,and on day eight ,one hour after drug administration ,a single dose of doxorubicin (15mg/kg), intraperitoneal was given.Serum MDA, LDH, Troponin I, and interleukine - 17. Were measured and histopathological changes also viewed?ResultsThe results in this study showed an increase in the cardiac biomarkers in the doxorubicin group compared to the control group, the cardiac biomarkers that measured are LDH, MDA, Troponin I, interleukine - 17. Also the results showed histopathalogical changes in cardiac tissue in doxorubicin group as compared to the control group, also the results showed the pre - treatment with verapamil, cyclosporine low dose, cyclosporine high dose, combination of verapamil and cyclosporine low dose, labetalol low dose, labetalol high dose showed decreasing in the cardiac biomarkers MDA, LDH, Troponin I, interleukine - 17 to a significant amount compared to the doxorubicin group, also showed histopathlogical improvement in cardiac tissue. Conclusions Doxorubicin drug used as antineoplastic agent will produce a toxic effect on the cardiac tissue, this toxic effect will limit the use of doxorubicin, cyclosporine, labetalol and verapamil produced differential effects and protection from Doxorubicin induced cardio toxicity via amelioration of cardiac biomarkers and histopathological changes

عزل وتحديد هوية فيروس الحصبة في علاقته ببعض الجوانب المناعية من الاشخاص النازحين الملقحين في محافظة بابل == Isolation And Identification Of Measles Virus In Relation To Some Immunological Aspects From The Vaccinated Displaced Individuals In Babylon Governorate

اسم المؤلف: ليث احمد عمران كيف الكيف
اسم المشرف: محمد عبد كاظم حسن السعدي | يونس عبد الرضا كحيوش الخفاجي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة لتقييم مناعة المجتمع لكلا النازحين والمقيمين الملقحين بلقاح فيروس الحصبة ضد خمج الحصبة في محافظة بابل. لذا تضمنت هذه الدراسة معايرة الحالة المناعية في امصال النازحين والمقيمين محافظة بابل مع عزل وتشخيص فيروس الحصبة من الحالات المشتبه بها. ت | The study was conducted to evaluate the herd immunity for both the displaced and residents vaccinated with measles virus vaccine against measles infection in Babylon governorate. Therefore this study includes the evaluation of the immune status in sera of Babylon governorate displaced and residents with specific aspect for isolation and identification of measles virus from suspected cases. The immune response was evaluated by means of ELISA test (enzyme linked immunosorbet assay) for titration of IgM and IgG immunoglobulin level, in addition to evaluation of perforin level in the sera of 90 measles vaccinated individuals included in this study (50 displaced and 40 residents) from different areas in Babylon governorate, that were collected during the period extent from January up to April of 2016. Data about individuals were fixed according to information of formula including age, sex, geographical location, place displace of displaced and the vaccination date. Successful virus isolation from suspected cases on two types of cells culture included Vero cells line and chicken embryo fibroblast was carried. The titer of the isolated virus on Vero cell line reached (105.8 TCID50 / 0.1ml),which was higher than the titer of the virus isolated on CEF which reach (105.4 TCID50 / 0.1ml) after the third passage of the virus. The isolated virus was confirmed by indirect immunofluorescence technique.The age of subjects included in this study ranged from <1 year up to 24 years old. The results revealed that 15 (30%) have positive IgM index in sera of displaced, whereas residents sera sample shown only 6 (15%) positivity. Howover, all 90 (100%) subjects of both groups showed positive IgG index. The results of the present study showed that there were no significant difference of perforin level in sera of refugees and residents at p<0.05.Assaying of immune response against measles virus by measuring IgM immunoglobulin in sera of vaccinated displaced and resident with measles vaccine reflected a highly significant difference between two groups which reached 0.43 mIU/ml in sera of displaced in comparison with residents sera which reached 0.34 mIU/ml. The result showed also high significant differences in IgM between females and males. The females sera IgM levels of displaced and residents were higher than its level in males sera which reached 0.47 mIU/ml and 0.35 mIU/ml, respectively, in comparison with male sera level which reached 0.40 mIU/ml and 0.32 mIU/ml, respectively. According to age group, the highest IgM value was recorded in displaced and residents sera in age group 10 - 14years (0.50 mIU/ml) and 5 - 9years (0.36 mIU/ml) respec - tively. Whereas the lowest IgM serum value was detected in age group <1 year (0.34 mIU/ml) and 15 - 19years (0.31 mIU/ml) for displaced and residents subjects. According to geographical location, the highest IgM level was detected in sera of displaced from Tal Afar city (0.44 mIU/ml) followed by displaced from Ramadi (0.41 mIU/ml) and the lowest IgM value was detected in sera of displaced from Mosul city (0.33 mIU/ml). Whereas the highest IgM value in sera of residents in the subjects of Al - Mahaweel city (0.37 mIU/ml) followed by subjects of Hilla and Al - Qasem city (0.29 mIU/ml and 0.28 mIU/ml) respectively. For IgG serum immunoglobulin the results revealed that there was no difference in significant levels in both group population. But according to age groups significant difference between displaced and residents was detected at p <0.05 in which the 1 - 4 years old showed the highest IgG serum level in both group (1.98 mIU/ml and 2.18 mIU/ml) respectively. While the lowest IgG sera value was recorded in displaced age group of < 1 year old (0.60 mIU/ml) compared with residents age group of 20 - 24 years old (1.65 mIU/ml).It could be concluded that the results showed that the displaced do not have any effect on the residents of the province of Babylon for measles as a result of the good immunization by Babil Health directorate following to the Ministry of Health.

تاثير استخدام عقار الميتفورمين منفردا او استعماله مجتمعا مع عقار كلكلزايد على مستوى الاومنتين - 1 - في مرضى داء السكري من النوع الثاني == Effects Of Metformin Alone Or In Combination With Gliclazide On Serum Omentin - 1 Levels In Patients With Type 2 Diabetes Mellitus

اسم المؤلف: سمر محمد غني سليمان
اسم المشرف: علي اسماعيل عبد الله محمد | حيدر فاضل الربيعي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لبحث التاثير العلاجي لاستخدام عقار الميتفورمين منفردا او استعماله مجتمعا مع عقار كلكلزايد على مستوى الاومنتين - 1 - باالاضافة الى المؤشرات الحيوية الاخرى في مرضى داء السكري من النوع الثاني من اجل تقييم ما اذا كان الجمع بين العقارين ( | Background : Omentin is a newly identified adipokine, which is highly expressed in visceral adipose tissue, in which omentin - 1 is the main isoform in human circulation, associated with cardio - metabolic disturbances. So considering the impact of anti - diabetic drug on omentin - 1 levels may provide adjuvant strategy to protect diabetic patients against clinical hazards.Aim of the study : The present study aimed to investigate the influence of treatment with metformin alone or in combination with gliclazide on the level of serum omentin - 1, in addition to the other biomarkers adopted in the study in order to evaluate whether the combined therapy (metformin plus gliclazide) ameliorate or adversely effects on some cardiac protector markers of metformin among recently diagnosed patients with type 2 diabetes mellitus.Methods : A total number of 100 recently diagnosed patients with type 2 diabetes mellitus were enrolled in the present study from December 2014 until June 2015. Sixty eight patients completed the 12 weeks course of treatment; divided into two equal groups based on treatment regimen in which group1 treated with metformin and group2 treated with metformin plus gliclazide. Thirty two patients did not complete the course of the treatment for unknown reasons and considered as default. In addition to 31 healthy volunteers were randomly chosen and considered as Control Group. In which all the participants in the study underwent detection of blood pressure, pulse rate, weight, height & BMI in addition to the estimation of the levels of others biochemical analysis as glycemic indices, lipid profile & serum omentin - 1at the beginning of the study & after 12 weeks of treatment regimen.Results : The results of this study shown the beneficial amelioration of metformin on some markers that affect CVS represented as significant reduction in BMI (p<0.05), modest improvement in lipid profile with modest elevation in HDL level & lowering blood pressure, significant reduction in the levels of blood glucose & HbA1C (p<0.05), improves insulin sensitivity, reduced insulin resistance, and elevation of serum omentin - 1 level among newly diagnosed type 2 diabetic patients (group1). Furthermore, the results of current study are revealed that adding of gliclazide to metformin in treatment of type 2 diabetic patients might influence the documented beneficial effects of metformin on cardiovascular system at least by adversely changing the levels of serum omentin - 1 among group 2. Conclusions : Adding of gliclazide to metformin in treatment of patients with type 2 DM might extend the therapeutic action of metformin in regarding much better controlling of glycemic indices, insulin sensitivity and lipid profile. But, at the same time, it might attenuate some of beneficial effects of metformin on cardiovascular system at least by adversely influence on body weight and serum omentin - 1 levels.

تاثير استخدام عقار النكلوزمايد بالمقارنة مع عقار المتفورمين على وزن الجسم ومؤشرات السكر في السمنة المحدثة عند الفئران == Effects Of Use Of Niclosamide Drug In Comparison With Metformin Drug On Body Weight And Glycemic Indices In High Fat Diet Induced Obese Mice

اسم المؤلف: خالد دهان صليبي
اسم المشرف: علي اسماعيل عبد الله محمد | خالد جمعة خليل
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: في ستينيات القرن الماضي كان هناك نوع من العلاجات تستخدم للسيطرة على وزن الجسم او لتخفيفه , تلك المواد تعمل على تثبيط عضيات المايتوكوندريا من انتاج الطاقة وتحويل مجرى تفاعلات الاكسدة نحو انتاج الحرارة بدلا عن الطاقة وبذلك تحفز من زيادة اكسدة الشحوم ومادة ا | Background : Obesity is a state of excessive accumulation of fat tissue in the body , increasing energy expenditure is good way to manage obesity and the related complications. Mitochondrial uncouplers increase energy expenditure , they used before for weight controlling programs because these compounds uncouple mitochondria from generating ATP , moreover stimulate lipid and glucose oxidation preventing lipid accumulation in excess caloric intake conditions specially. Niclosamide an old drug introduced in 1960s as anthelmintic and had FDA approval for the treatment of most of tapeworm infections. It is well known mitochondrial uncoupler.Aim of the study : The present study aimed to investigate the influence of trial of the use of niclosamide in comparison to effect of metformin and their combination on body weight , glycemic indices and lipid profile in high fat diet induced obese mice.Materials and methods : The animals firstly divided to two groups one fed with normal regular mouse chow (30 mice) and the 2nd fed with high fat diet (60%kcal) for 2.5 months(100 mice) 10 mice from each group sacrificed at beginning of study represent baseline values and another 10 mice from each group sacrificed after 2.5 months to assess effect of high fat diet on study parameters. The group that fed with high fat diet further subdivided to 4 groups after 2.5 month of high fat diet feeding each 20 mice , 10 mice from each group sacrificed before treatment represent pretreatment values. Before treatment there are 5 groups assigned as group 1 fed normal regular mouse chow till the end of study , group 2 fed high fat diet without treatment till the end of study , group 3 fed with high fat diet till the end of study and treated with niclosamide for one month (150mg/kg) after obesity induction by high fat diet , group 4 fed with high fat diet till the end and treated by metformin (300mg/kg) for one month and finally group 5 fed with high fat diet till the end of study and treated by combination of niclosamide and metformin (150mg/kg , 300mg/kg respectively). blood samples taken from tail vein to evaluate the study parameters at baseline and after obesity induction by high fat diet (after 2.5 months) and after treatment ,then animals were sacrificed and livers were taken for histopathological observations.Results : The results of this study shown that the animals fed with high fat diet show metabolic disturbances manifested by significant increase (P < 0.05) in body weight , fasting insulin & fasting plasma glucose. Lipid profile show significant changes (P < 0.05)(cholesterol , triglycerides ,low density lipoproteins increased while high density lipoproteins decreased ) as compared to control group. High fat diet group also show impaired glucose tolerance , impaired insulin sensitivity and obvious liver structural changes manifested by sever steatosis.Treatment with niclosamide show improvement in all metabolic disturbances induced by obesity ; body Weight , fasting insulin and fasting plasma glucose reduced significantly (P < 0.05). Lipid profile parameters improved ; cholesterol , triglycerides , low density lipoproteins reduced significantly (P < 0.05) by one month treatment with niclosamide and high density lipoproteins increased significantly (P < 0.05) as compared to their baseline values before treatment, Glucose and insulin tolerance improved. It is nice to mention the influence of niclosamide in this study was comparable to metformin in all evaluated parameters.Combination of both drugs show favorable improvement in metabolic disturbances induced by obesity rather than each drug when used alone specially on liver histopathological changes.Combination of both drugs show significant reduction (P < 0.05) in body weight ,fasting plasma glucose and fasting plasma insulin. Lipid profile parameters improved significantly (P < 0.05) , glucose and insulin tolerance improved.Liver histopathological changes ameliorated to higher extent and become the closet to normal liver tissue morphology.Conclusions : The result suggest niclosamide have good antidiabetic action and can ameliorate the metabolic changes induced by obesity significantly. Its action is comparable to that of well known antidiabetic drug metformin. Niclosamide has favorable effect on body weight and can reduce body weight. Its combination with metformin show better improvement in metabolic disturbances induced by obesity and it has very good hepatoprotective effect against liver histopathological changes induced by high fat diet.

دراسة مستوى الهيبسيدين ومستقبلات الترانسفرين في عينات من المرضى العراقيين المصابين بحالات فقر دم نقص الحديد واضطرابات زيادة الحديد في الدم == Study Of Hepcidin Level And Transferrin Level In Samples Of Iraqi Patients With Iron Overload And Iron Deficiency Disorders

اسم المؤلف: داليا نايف جاسم
اسم المشرف: علاء الدين مظفر زبير القاسم
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: الامراض - الدم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The circulating peptide hepcidin is secreted mainly by the liver as an 84 - amino acid precursor that is subsequently processed and secreted as a 25 - amino acid peptide form. It is considered the "master regulator" of iron metabolism.Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin - iron complex through receptor - mediated endocytosis. This study addresses the physiological role of hepcidin in vivo and investigates the role of hepcidin as an erythroid regulator, contributing to the modulation of iron absorption by the intestine and iron release by the macrophages in the situation of anemia with normal or increased iron stores. Measuring the transferrin receptor level and it's relation to hepcidin is another part of the data involved in this study.Methods : This study included 64 Iraqi patients, 34 of them have iron deficiency anemia and the other 30 are iron overload patients. They attended the National Center of Hematology and Thalassemia center in Al - Karama Teaching Hospital during the period from October 2014 until April 2015 together with 30 healthy controls. Information regarding age, sex and clinical presentation were recorded. ELISA technique used to measure hepcidin and transferrin receptors level in patients and healthy control groups.Results : ? Mean serum hepcidin level in iron deficiency anemia patients was (205.3ng/ml) while in iron overload patients was (6.7ng/ml).? Mean serum level of transferrin receptors in iron deficiency anemia was (11006.3ng/ml) and in iron overload was (604.5ng/ml).Conclusion : ? The mean level of serum hepcidin in thirty iron deficiency anemia patients is high. Its elevation represented an acute phase response. While in thirty patients with iron overload, hepcidin mean level was low mainly due to stress erythropoiesis.? The current study result addresses the usefulness of soluble transferrin receptor for assessing high iron status in population and how soluble transferrin receptor is useful in the evaluation of anemic patients.

تقييم نظام المعلومات الصحي في العراق == Assessment Of The National Health Information System In Iraq

اسم المؤلف: ثائر عيسى مراد
اسم المشرف: مازن غازي جاسم الربيعي | امجد داود نيازي
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تعتبر الاحصائيات الصحية الرصينة ضرورة لاتخاذ القرارات السليمة في كل مستويات النظام الصحي. ولكن في الحقيقة ان نظم المعلومات الصحية في معظم البلدان تعتبر غير كافية لتوفير المعلومات اللا زمة لدعم الادارة الصحية ولهذا فان معظم النظم الحالية تعتبر كعائق اداري | Sound health statistics are essential for health decision - making at all levels of the health system. Unfortunately, health information systems in most countries are inadequate in providing the needed management support and the current systems are therefore widely seen as management obstacles rather than as tools, the current study is an attempt to assess the health information system in Iraq with recognizing the strengths, weaknesses and gaps in addition to assessment of the structure and performance of this system; it also attempts to assess the behavioral, technical and organizational determinants affecting the health information system performance. A cross - sectional study was conducted for the assessment process and the levels of the assessment included the ministry of health (national level), the health directorates (provincial level), the districts related to the health directorates reaching to the health centers level, as well as the hospitals related to the health directorates, in addition to the ministry of planning and the ministry of interior. In addition to ministry of health (central level) a total of six governorates were selected by simple random sampling including the capital Baghdad with a seven districts were selected from those governorates also by simple random sampling and a total of twenty six health centers were selected from those districts, as well a total of seven hospitals were included in the study from all governorate and they were selected according to convenience. The interview has been done by using the health metrics network assessment tool version 4, in addition to a complementary assessment tools which are the PRISM package tools that were used at the district and primary health center levels. Based on the data collected and according to the health metric network assessment tool findings the overall health information system has laid in the adequate state (65.96%) with most of its comprising components function poorly. Data dissemination and use and data management categories were the weakest with a score of 50% and 53.3% respectively, while for the resources category it was found to be adequate 63.3%, and for that of HIS indicators, data sources and information product categories they were 73.3%, 66% and 69.6% respectively. For that of the PRISM tools and the findings obtained by them from the collected data the results revealed that a low data quality in term of accuracy with 29.03% at the facility level and 55.35% at the district level, while the completeness rate was excellent with a score 96.38% at the facility level and 98.23% at the district level, for that of the timeliness it was 70.43% timeliness at the district level. The information use for a given feedback at the facility was 50% and at the district was 82.12% and for observed meeting records it was 50% for the facility and 41.6% for the district level. For that of the functionality a 34.61and 67.30% of the facilities reported having a reminder mechanism for data completeness process and meeting a deadline for submitting monthly reports respectively, Data analysis was better at the district 85.71% than at the facility 81.7%, Data display were present in all of the facilities and districts. For the technical determinant the results showed 57%, 85.7%, 71.4% and 100% of the district respondents felt that the form is complex and difficult to follow, data software is a user - friendly, information technology is easy to manage and a comprehensive picture of the health system performance is captured by the system respectively,85.7% believed that the information system collecting information from some vertical programs and one district reported of no collection at all, in addition to that 100% reported the absence of a software that integrates data from different information systems and the available information technology doesn&#39;t provide full access procedure to district and senior managers. Regarding the behavioral determinants the results revealed that overall mean confidence for the information system tasks is 69.41% while for that of the task competence the overall mean competence level is 37.1%. Knowledge of checking data quality, knowledge of health information system rationale and problem solving showed results of 35.32% 37.68% and 2.98% respectively, and that of motivation level was 43.4%. Organizational determinants results revealed that the management functions at facility and district levels were almost absent, while for the perceived promotion of a culture of information it showed a total score of 63.96% and rewarding for a good performance was 56.83%. The activities for promotion of a culture of information are a 25% at the facility level and 28.75% at the district level. And that of supervision quality at the facility were (72.80%). Availability of resources revealed that 100% of the facilities have two or more computers and calculators respectively while only 57.7% have an internet access. Access to the electricity and water supply is very high, No facility reported of running out in registers in the last 12 months. Finally, the current study shows the importance for the need of further attention to be drawn to HIS, in addition to that, increasing the awareness and well coordinated efforts that need to be done to overcome weaknesses and to provide a well functioning HIS enabling for evidence based decision making and action provision in the health system.

تاثيرات السيتاكولين ,الجنسنك واستخدامهما معا على الذاكرة العملية والاداء الحركي النفسي == Effects Of Citicoline, Ginseng, And Their Combination On Psychomotor Performance And Working Memory

اسم المؤلف: تيسير لطيف علي
اسم المشرف: حيدر القريشي
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اساس الدراسة : اجريت الدراسة الحالية لتقييم التاثير العلاجي لعقار السيتاكولين والجنسنك واستخدامهما معا على الذاكرة القصيرة المدى والاداء الحسي الحركي, وذلك من خلال دراسة الاثار المركزية والطرفية للعقارين على مقاييس الاداء الحسي الحركي , الذاكرة العمليه , | Citicoline is one of components that present in the human brain, which act to protect the neurons and enhance memory and other cognitive functions due to its choline in their structure which play an important role in the biological membrane biosynthesis. On other hand Ginseng is an herbal plant is known for its therapeutic medical importance, it's used for different purposes in medical fields, that is effective against many diseases, act as a tonic and provide energy with significant reduction in mental and physical fatigue.Aims of the study To evaluate the central effects of Panax Ginseng and/or citicoline on normal healthy volunteers.Material and Method The subjects are randomly divided into four groups for assessment of central effects of Panax Ginseng and /or citicoline compared with placebo. The evaluation of the central effects was done by using the Leeds psychomotor battery tester for evaluating the psychomotor performance, workshop test was used to evaluate working memory function.The enrolled volunteers were randomly divided into the following groups : First group regarded as control group that treated with 500 mg/day of starch capsule as a single dose, second group, received Panax Ginseng capsule 500 mg /day, a third group received citicoline capsule 500 mg/day and the fourth group received Panax Ginseng capsule 500 mg/day plus citicoline capsule 500 mg/day as a single dose. All participants are followed for two consecutive weeks from starting treatments.ResultsIn the present study the placebo didn't have any central effect and MDA serum levels were not significantly change. Panax Ginseng has statistically significant effect on the most parameters of the psychomotor performance, working memory performance, as well as reduction of MDA serum levels. On the other hand, citicoline has statistically a significant effects on most parameters of the psychomotor and working memory function with statistically significant reduction of MDA serum levels.The combination of Panax Ginseng and citicoline have a highly statistically significant effect on all psychomotor performance, working memory performance and statistically significant reduction in the oxidative stress marker (MDA). ConclusionResults of the present study showed that combined effects of citicoline plus Panax Ginseng on central function produced more statistically significant effects on psychomotor performances, CFFF and working memory function than either Panax Ginseng or citicoline when they used alone, in addition to the combined effects of citicoline plus Panax Ginseng have a more significant effect on the oxidative stress,during mental stress.

تقييم وحدات الرعاية المركزة لحديثي الولادة في ردهات الولادة لمستشفيات بغداد == Evaluation Of Neonatal Intensive Care Units At Maternity Wards In Baghdad Hospitals

اسم المؤلف: بشرى احمد عبد اللطيف
اسم المشرف: جمال محمود الخضيري
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: طب المجتمع
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تتباين انظمة الرعاية لحديثي الولادة المطبقة ولكنها كلها تعتمد على وحدات الخدج الموجودة في مختلف بلدان العالم النامية والمتقدمة.انجزت هذه الدراسة المقطعية التقويمية في وحدات حديثي الولادة لردهات الولادة في مستشفيات بغداد (الكرخ والرصافة) مستثنين وحدات ال | Neonatal health care is provided via a variety of neonatal care units that are available globally both in different developing and developed countries.A cross - sectional evaluation study was conducted in all accessible fifteen neonatal intensive care units in Baghdad (Kharkh and Rosafa) maternity wards, excluding paediatric hospitals, during the period from November 2013 till the end of March 2014.The study aims : 1. Health care evaluation in neonatal intensive care units of maternity wards in Baghdad hospitals in terms of input (human and non - human resources) and outcome.2. Identifying causes of admissions and causes of deaths occurring in neonatal intensive care units The study consisted of two parts : A structure evaluation is using a check list to assess availability of human and non - human resources, covering infrastructure, manpower, equipment, and supplies; and an outcome evaluation study using hospital registration records review for causes of admission and causes of death in neonatal intensive care units during the year 2013.It was found that the mean number of specialist doctors in neonatal intensive care units was 2.1 and with standard deviation ±1.3, and college nurse was 2.2, with standard deviation of ±4.004, pharmacist was 0.4 with standard deviation of± 0.516 and for supplementary staff 1.5 with standard deviation of± 0.516.More than half 54% of nurses had no training in neonatal care.Concerning the availability of general equipment it was adequate except for computers 40%.Air conditioning, lighting and windows in addition to safe water supply was good 100% but ventilation was poor 67%, hand washing area was not always present 60% and free elbow operated water tubes were available in 6.7%. Availability of neonatal intensive care units special area was adequate for storage area 85.7% gowning area78.6%, while all the remaining areas were poorly available (resting room, examining room, mother room, boiling and autoclave room, area for mixing intravenous fluid and medication).Neonatal intensive care units were narrow and area/incubator ranging from 2.28m2 to 4.36m2/ incubator. Number of incubators was 246 with patient/ incubator ratio 53.6 : 1 and 27% of Neonatal intensive care units had no regular maintenance for incubators. Large Neonatal intensive care units >25 incubators were overcrowded, having below standards area/incubator, incubators covers only two third of neonatal care. Still up to one third of Neonatal intensive care units are getting their oxygen supply by cylinders, not pipes. Most equipment for individual use were poorly available. Most of Neonatal intensive care units emergency (cupboard) drugs and supplies were sufficiently available round the clock. Total admissions to Neonatal intensive care units were 13195 neonates. Male neonate's admissions 60% were higher than females 40%. Main causes of admission were Respiratory distress syndrome 43%, prematurity and low birth weight 19.4%, and Transient tachypnea 17.4%; birth asphyxia 4%, and hypoglycemia 3.8%, Congenital anomalies 3.7%, Neonatal jaundice 3%, while meconium aspiration and septicemia were the lowest1%. From all these admissions 74% were discharged well, (6%) were referred, while those discharged against medical advice were (4%) and the rest (16%) died. The main causes of death in Neonatal intensive care units were Respiratory distress syndrome 34%, prematurity and low birth weight 31% congenital anomalies 12%, birth asphyxia 8%, septicemia 4%, meconium aspiration 1% and 10% due to other unclassified causes. From this evaluation study, it can be concluded that there were Neonatal intensive care units with under staffing, undertraining and poor designing. Respiratory distress syndrome and prematurity were the main neonatal health problems.

تقييم استخدام الروزوفاستاتين والتلميسرتان في حالة تسمم عضلة القلب الحاد المحدث من استخدام الدوكسوروبيسيبن في الجرذان المختبرية == Evaluation The Usage Of Rosuvastatin And Telmisartan In Doxorubicin Induced Acute Cardiotoxicity In Rats

اسم المؤلف: ايهاب اياد احمد
اسم المشرف: علي اسماعيل عبد الله محمد | خالد جمعة خليل
الموضوع العام: الطب
السنة: 2014
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية لتقييم التاثيرالعلاجي لاستخدام الروزوفاستاتين والتلمسارتان في التقليل من سمية القلب المحدثة من عقار الدوكسوروبسين في الجرذان المختبريةباستخدام الطرق الكيميائية الحيوية والنسيجية ومقارنة تاثير الاستخدام المزدوج بفعالية استخدام كل م | Background : Doxorubicin, an anthracycline antibiotic is a powerful antineoplastic drug, but its therapeutic usefulness is limited by its cardiotoxicity. Aim of the study : The present study investigated the influence of pretreatment with rosuvastatin and telmisartan alone or in combination in different doses on doxorubicin induced acute cardiotoxicity in rats using biochemical and histological approaches. Materials and methods : The animals were divided into eight groups of 5 animals each. The first group received no drug(s) po but a single dose of distilled water (7.5 ml/kg, ip) on day eight, which serves as the control group. The second group received no drug(s) po but a single dose of doxorubicin (15 mg/kg, ip) on day eight, and serves as doxorubicin only received group. The third and sixth group received rosuvastatin (2 , 10) mg/kg/day respectively for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given. The fourth and seventh group received telmisartan (2 , 4) mg/kg/day respectively for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given. The fifth and eighth group received both drugs, where the fifth group received both of rosuvastatin (2 mg/kg, po) and telmisartan (2 mg/kg, po), 1 hour apart, daily for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given. While the eighth group received both of rosuvastatin (10 mg/kg, po) and telmisartan (4 mg/kg, po), 1 hour apart, daily for nine successive days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15 mg/kg, ip) was given.At day ten of the study, blood samples were taken for biochemical analysis, then animals were sacrificed and hearts were taken for histopathological observations. Results : Rats treated with doxorubicin showed cardiotoxicity as evidenced by significant elevation of serum cardiac troponin (CTn - I) level, lactate dehydrogenase (LDH) activity, serum malondialdehyde (MDA) level, and interluekine 17 (IL - 17) level associated with important histopathological alterations while pre - treatment with rosuvastatin and telmisartan elicited a significant decrease in the activities of all markers measured in comparison with doxorubicin treated group with pronounced resolution of Dox induced cardiac histological changes to a milder picture.Conclusion : These results suggest pretreatment with rosuvastatin and telmisartan alone or in combination provide a significant protective effect against acute - doxorubicin induced cardiotoxicity in rats represented by biochemical markers and histological approaches.

العلاقة بين تجارب الطفولة السيئة والمطاوعة على الصحة بعد البلوغ في بغداد == The Relationship Of Adverse Childhood Experiences And Resilience To Adult's Health In Baghdad City

اسم المؤلف: اميل فاروق الشاوي
اسم المشرف: رياض خضير لفتة | صالح الحسناوي
الموضوع العام: الطب
السنة: 2015
الموضوع الدقيق: طب المجتمع
الدرجة: دكتوراه
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: تجارب الطفولة السيئة تشير الى اكثر مصادر الاجهاد شيوعا وشدة التي يعاني منها الاطفال في حياتهم المبكرة. من هذه الخبرات الاساءة، الاهمال، العنف بين الابوين او مقدمي الرعاية والعنف المجتمعي. وتبين ان الاجهاد الطويل في الطفولة له اثار طيلة الحياة على صحة | Adverse Childhood Experiences refer to some of the most intensive and frequently occurring sources of stress that children may suffer early in life. Such experiences include multiple types of abuse; neglect; violence between parents or caregivers and community violence exposure. It has been shown that prolonged stress in childhood has life - long consequences for a person's health and well - being; it may lead to serious problems such as alcoholism, depression, eating disorders, heart diseases, cancer, and other chronic diseases. Resilience is the ability to manage crises, difficult situations and developmental tasks. Research on resilience has identified several factors that strengthen the power and resources of children as well as promote their abilities to cope successfully with crises and internal and external problems. This cross - sectional study was conducted to estimate the effect of adverse childhood experiences and resilient factors on adults’ heath. It was done during the period from January 2013 through January 2014. The study sample was drawn from Baghdad City. Multistage sampling technique was used to choose 13 primary health care centers and eight colleges from three universities in Baghdad; the questionnaire was filled through a direct interview with the participants. In addition to that, teachers of seven primary schools and two secondary schools were chosen by a convenient method. A total of 1040 subjects were surveyed and 1000 responded. Their age ranged between 18 to 59 years (32.08±11.169). Females constituted a higher proportion (58.3%) of the study sample, 60% of this sample had university/diploma as the highest level of education. The results showed (during childhood) that seeing or hearing a parent or household member in home being yelled at, screamed at, sworn at, insulted or humiliated was reported in 469 (46.9%). A parent, guardian or other household member yelled, screamed or swear at, insulted or humiliated them was registered in 387 (38.7%). A parent, guardian or other household member spanked, slapped, kicked, punched the subjects was seen in 335 (33.5%). father's death (when the subject's age was 15 years or less) was reported in 104 (10.4%) of the participants, and 74.8 % of the subjects like to be the kind of people their parents were. The multiple linear regression models demonstrated that being in the fourth quartile (highest quartile) of household dysfunction - abuse score is expected to significantly increase depression symptoms score by a mean of (10.4) compared to subjects in the lowest (first quartile) of household dysfunction - abuse score, being in the fourth quartile of family bonding score is expected to significantly decrease depression symptoms score by a mean of ( - 22.5) compared to subjects in the first quartile, the same is correct for self - esteem score which increases by a mean of (21.484) for the fourth quartile of family bonding score compared to subjects with lowest (first quartile) after adjusting other explanatory variables. Logistic regression model showed that being in a higher level of family bonding (fourth quartile) is expected to reduce the risk of having chronic physical diseases by almost the half (odds ratio =0.57) and being exposed to a high level of household dysfunction and abuse (fourth quartile) is expected to increase the risk of having chronic physical diseases by 81%. A positive history of suicidal attempts showed a strong positive association with mean score of household dysfunction and abuse. Family bonding during childhood appears to be the most important resilient factor that protects adults against sedative or narcotic usage, mental disorders, suicide attempts, and chronic physical diseases during adulthood. Higher levels of exposure to adverse childhood experiences have a positive association with substances usage, suicide attempts, symptoms of mental disorders and chronic physical diseases in adulthood.

التغيرات الكيما حيوية في مصل الدم لتراكيز الهيبسيدين والانترلوكين - 6 نسبة لحالة الحديد قبل وبعد العلاج الكيميائي عند المرضى البالغين المصابين بسرطان الدم النيقاني الحاد == Biochemical Changes In Hepcidin And IL - 6 Concentrations Relative To Iron Status In Patients With Acute Myeloid Leukemia Before And After Treatment

اسم المؤلف: هبة عمار محمد
اسم المشرف: ختام عبد الوهاب علي | علاء فاضل علوان
الموضوع العام: الطب
السنة: 2015
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: هدف الدراسة : لتعيين العلاقة بين هرمون الهبيسيدين (hepcidin) (الهرمون المنظم لتوازن الحديد في الجسم والانترلوكين - 6 ( (interlukin - 6و علاقتها ببعض المتغيرات الكيميائية الحياتية عند المرضى المصابين بابيضاض الدم النيقاني الحاد ((AML قبل وبعد اكمال الجرعة الك | Acute myeloid leukemia (AML) is a clonal, malignant disease of hematopoietic tissues characterized by the accumulation of abnormal blast cells, especially in bone marrow, and impaired production of normal blood cells. The statistics show that this disease in men is more prevalent than women and this type of leukemia is increasing with age. Objectives : To assess biochemical changes related to iron status in acute myeloid leukemia pre and post course of chemotherapy and evaluate a relationship between serum hepcidin and IL - 6 in patients with acute myeloid leukemia pre and post chemotherapy and compare their levels to controls and their contribution on the pathogenesis of AML.Patients, Materials and Methods : The present study conducted at the National Center of Hematology and Baghdad Teaching Hospital in the Medical City from February 2014 to June 2014.The study included Fifty - eight (58) patients (30 male and 28 female) diagnosed with acute myeloid leukemia the age of patients range (15 - 65 years). Forty three (43)patients continued the study (24 male and 19 female) divided into two groups : Group (1) Patients with AML before starting chemotherapy. Group (2) the patients after 4 weeks of chemotherapy. Patient's treatment was done according to international protocol used in acute myeloid leukemia and called (3+7) where Doxorubicin was given from the first day to third day and Cyatrabine (Ara - C) was given from the first day to seventh day.Evaluationwas done on day (28) from starting chemotherapy to assess response of patients through bone marrow aspiration.All patients were subjected to complete history and physical examination. Diagnosis of AML patients was established by complete blood count and blood film, bone morrow aspiration and biopsy, hepcidin, interlukine - 6, C - reactive protein, ferritin, iron, total iron binding capacity, alkaline phosphstase, direct bilirubin were done for all patients.Forty - three (43) healthy subjects (24 male and 19 female) were enrolled in the study mainly from medical staff and their families. They were age and sex matched to patients group and considered as controls as ( Group 3).Results : • Serum hipcidin levels were significantly higher in(AML)patients (Group 2) compared to newly diagnosed(Group 1) and to healthy subjects ( P<0.0001).• Serum (IL - 6) levels were higher but not significant in(Group 1) compared to (Group 2) and significantly with healthy controls(P<0.214 and P<0.0001 respectively).• A significant increase in mean of serum ferritin levels were observed in (Group 2) compared to newly diagnosed patients (Group 1)(P<0.002) and the levels were significantly higher in newly diagnosed group compared to healthy controls (P<0.015).• Patients with (AML) during remission show significant decrease in levels of iron compared to newly diagnosed group(P<0.0001),while levels in healthy controls was higher values than both (Group 2) and (Group 1) (P<0.0001).• Total iron binding capacity (TIBC ) levels showed a significant decrease in (Group 2) after treatment compared to (Group 1) before treatment(P<0.0001) but the levels were significantly higher in healthy controls compared to (Group 1) and (Group 2) (P<0.0001).• Mean serum ALP levels showed highly increase in (Group 2) patients when compared to patients before treatment (Group 1)( P<0.0001), but the difference is not significantly higher between the newly diagnosis and controls (P<0.687).• A significant increase in mean serum direct bilirubin levels were observed in (Group 2) patients when compared to (Group 1) and healthy controls(P<0.0001).• Regarded to CRP levels in AML patients before and after treatment, the CRP levels increased in AML patients after treatment than newly diagnosed AML patients.Conclusions : Hepcidin and Interlukin - 6 may be used asprognostic for acute myeloid leukemia and also can play an important role in pathogenesis of AML.

دور هرمونات الاديبونكتيندور واللبتين والسايتوكينات لدى بعض المرضى المصابين بعجز القلب المزمن == Role Of Adiponectin Leptin&Other Cytokines In Some Chronic Heart Failure Patients

اسم المؤلف: نور نصير نافع
اسم المشرف: عدنان فاضل النجار | صباح موسى فاضل
الموضوع العام: الطب
السنة: 2010
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Adiponectin
  • leptin
  • cytokine
  • Chronic Heart Failure
الصفحات الاولى:
المستخلص: عجز لقلب المزمن : حالة تقويضية معقدة متمثلة بمرحلة تشخيصية متقدمة مدمرة ونهائية. ان عملية انتقال المرض من مستقر الى دنف القلب(اعتلال عام مع هزال) ليست مفهومة جيدا, وهناك عدد من العمليات المختلفة للحفاظ من عملية الهدر، وهي في معظمها حيث وجدت لتكون في وقت م | Chronic Heart Failure(CHF)is a complex catabolic state that carries a devastating prognosis. The transmission from stable disease to cardiac cachexia is not well understood. A number of different mechanism maintain the wasting process, most of which were found to be activated early in the development of CHF.Many of these pathways are initially activated to protect heart from damage and to compensate for impaired myocardial function. Mediators that have been implicated in this process include pro - inflammatory cytokines like interleukin 1 and 6, tumour necrosis factor - ? and the acute phase protein (C.R - P)these cytokines are activated during the course of CHF and maintaining the wasting process. Little is known about the mechanism leading to cardiac cachexia (C.C).Adiponectin and leptin are a protein hormones derived from adipocytes and they are important regulator of energy metabolism and body weight. Previous studies of CHF and C.C , had great differences between cachectic and non - cachectic patients.OBJECTIVETo study the relationship between Adiponectin, leptin & cytokines in cachectic &non cachectic HF patients & compared the results with coronary artery disease( CAD) patients with preserved left ventricular systolic function( LVSF) &healthy control to elucidate their roles in pathobiochemistary of cachexia, & to study the prognostic power of adiponectin in CHF, also to identify & confirm the role of proinflammatory cytokine(IL - 6& TNF - ?)& systemic inflammation marker (C - R.P)in the progression of CHF to cardiac cachexia.SUBJECTS &METHODE Studies were performed in Cardiology Clinics in Ibn Al - Betar hospital for cardiac surgery. Eighty eight subjects were divided into four groups each contain 22 subjects are enrolled in this study : 1st group : patient with HF(reduce LVSF)with cachexia include 5 females &17 males with age range from 47 - 76 years;2nd group : patients with HF(reduce LVSF)but without cachexia include 6 females& 16 males with age range from 34 - 70 years;3rd group : patients with CAD (preserved LVSF)include 11 males &11 females with age range from35 - 80 years & 4th group : consisted of healthy controls include 11male s& 11 females with age range from 36 - 65 years. The hormonal assay was done by ELISA.RESULTSPatients with CHF with cachexia had significantly higher concentrations of adiponectin than all other groups(p=0.004) ,that are associated with significant decrease in serum level of leptin(p=0.002), significant increase in serum level of IL - 6 when compared to other groups (p=0.0001)& significant increase in number of C - R.P positive compared only to healthy control(p=0.007),but serum level of TNF - ? is significantly decrease when compared to both CAD(p=0.023) &healthy control (p=0.0001)although it was non - significant decrease when comper to patient with CHF without cachexia.In the patient with CHF without cachexia, non - significant increase in serum level of adiponectin (when compared to patient with CAD with preserved LVSF& non - significant decrease compare to healthy control), while serum level of leptin was non - significantly decrease (when compared to patient with CAD with preserved LVSF & non - significant increase when compared to healthy control) associated with non - significant decrease in serum level of TNF - ? in comparison to CAD with preserved LVSF but significant decrease compared healthy control(p=0.011)while serum level of IL - 6 significantly increase in comparison to both CAD with preserved LVSF(p=0.01) &healthy control(p=0.008).In CAD with preserved LVSF non - significant decrease in serum level of adiponectin,while non - significant increase in serum level of both leptin , IL - 6 & TNF - ? when compared to healthy control. In this study there is strong significant positive correlation between adiponectin & TNF - ? in patients with CAD with preserved LVSF(r=0.615,p=0.002); while adiponectin was positively correlated with E.F% in patients with CAD with preserved LVSF(r=0.448,p=0.037).Finally there is significant positive correlation between TNF - ? & IL - 6 in patients with CHF with cachexia(r=0.466,p=0.029).CONCLUSIONCachexia, is a catabolic state of CHF associated with increase in serum adiponectin concentration, this may be consider as preservation of physical response to the changes in body fat but might also suggest that adiponectin plays a role in pathogenesis of cachexia, while cachexia associated with HF is not caused by enhance leptin release but, by increased level of adiponectin which is powerful predictor of cardiac cachexia.Cardiovascular Disease(CVD) is associated with elevated marker of systemic inflammation)C - R.P(that plays important role in disease progression& increase level of proinflamnmatory cytokine)IL - 6(has been reported as important pathogenic factor contributed to cardiac injury during CHF& progression to cardiac cachexia, although ,the level of TNF - ? is lower & has no relation to the degree of cachexia

تقييم نسبة الاديبونيكتين والانترلوكين - 6 واضداد البروتين الستروليني في مصل الدم وتركيب الجسم مع الكثافة الكتلوية للعظم لدى المرضى المصابين بالفصال العظمي العقدي == Evaluation Of Serum Adiponectin , Interleukin - 6 , Anti - Cyclic Citrulinated Peptide And Body Mass Index With Bone Mineral Density In Nodal Osteoarthritis Patients

اسم المؤلف: مصطفى سالم خلف
اسم المشرف: عدنان فاضل النجار | عباس طعمة جودة الخزاعي
الموضوع العام: الطب
السنة: 2015
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الفصا العظمي العقدي هو واحد من انواع التهاب المفاصل الموضعي. هو مرض المفصل التنكسي او الانحلالي, ويشمل الغضروف المفصلي والعظم تحت الغضروف, وهو يعتبر نوع من انواع امراض المناعة الذاتية. السبب الرئيسي للفصال العظمي العقدي غير معروف لكن هناك اسباب متنوعة مثل | Nodal osteoarthritis (NOA) is one type of the localised osteoarthritis that mostly occurs with postmenopausal women. It is degenerative joint disease, including articular cartilage and subchondral bone, it consider type of autoimmune diseases. The main cause of NOA is unknown but there are variety of causes like hereditary and metabolic, may initiate processes leading to loss of cartilage. The cartilage loss process usually lead to induce the immune system to release many of immune factors like cytokines , these factors lead to generation of immune response and inflammation in the joint. The NOA mostly occurs with postmenopausal women. It affects the smaller joint. Over several years, firm knobbly swellings form on the finger joints. These are caused by osteophytes so lead to bony enlargement and are known as Heberden's nodes when they are at the end joints of fingers (distal interphalangeal joints) or Bouchard's nodes when they are at the mid - finger joints (proximal interphalangeal joints). Once the nodes are fully formed, and not necessarily painful, they do limit the movement of the fingers significantly. NOA leads to the formation of bunions, rendering them red or swollen. Some people notice these physical changes before they experience any pain, but in advance cases, many of Symptoms may include like joint pain, stiffness and sometimes an effusion. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax.Many studies have been done about inflammatory and biochemical markers in NOA and they found conflicting results. Objective1 - To evaluate serum adiponectin , interleukin - 6 (IL - 6) , anti cyclic citrullinated peptide (ACCP) and bone mineral density (BMD) in NOA.2 - To asses the CRP , RF and ESR in NOA.3 - To asses effect of age , gender , effect of BMI , smoking habit and duration of disease in NOA.Material and Method This study performed during the period from November 2013 to February 2014. These subjects were selected from patients attending the Rheumatology & Rehabilitation Consultation Unit at Al - Yarmouk Teaching Hospital. Patients and controls with hypertension, diabetes mellitus, malignancy, chronic disease of kidney, liver and any patients taken drugs that might effect the results have been excluded from the study.The laboratory tests were done in Al - Yarmouk teaching hospital laboratories and the laboratory research unit in collage of medicine / department of medical biochemistry. Subjects80 subjects (60 patients & 20 healthy controls) were enrolled in this study : A. First group : Patients with Nodal Osteoarthritis (NOA), No. = 60 (female =49 & male =11), rang of age (40 - 88) years.B. Second group : Healthy control group who had no history or clinical evidence of NOA or any other chronic disease like hypertension, DM and other chronic disease that might effect on the study data, No. 20 (female = 15 & male =5 ), rang of age (48 - 82) years.The patients were diagnosed as NOA according to the 2013 American College of Rheumatology (ACR) criteria, also the patients were diagnosed as normal, osteopenia and osteoporosis according to the 2013 American College of Rheumatology (ACR) criteria by measured of BMD (T - score) Normal : T - score (more than or equal - 1), Osteopenia : T - score ( - 1.1 - - 2.5) and Osteoporosis : T - score (less than - 2.5). The patients BMI were measured and determined as Normal (18 - 24.9 kg/m2), Over weight (24.9 - 29.9 Kg/m2), Obese grade - I (29.9 - 34.9 kg/m2) and Obese grade - II (more than 34.9 kg/m2) according to WHO 2012.MethodsELISA technique was used for the determination of serum adiponectin, IL - 6 and ACCP. Measurement of serum uric acid was done by spectrophotometric instrument. qualitative serological tests were used for determination of the CRP and RF also ESR determination were done in hospital laboratory. The BMI was determined by WHO equation's (2012) (weight/ (length) 2), also the BMD was determined by DXA scan according to ACR limits.Results obtained were subjected to statistical analysis by using SPSS and Excel program.ResultsLevels of serum adiponectin, IL - 6, CRP, ESR and BMI were significantly increased in NOA patients most than healthy controls, also the BMD (T - score) significantly decreased in NOA patients than healthy controls. But the age, gender, serum ACCP and uric acid were not significantly changed in NOA patients compared with healthy controls. Study of age, gende , BMI and duration of disease, found that they did not effect any parameters studied in NOA patients, only serum ACCP level was found to be significantly increased in females than males. Serum adiponectin level and CRP were significantly increased more in osteoporosis than osteopenia and normal. CRP was significantly increased in smoker than non smoker NOA patients.This study showed negative correlation between serum adiponectin and BMD, positive correlation between serum adiponectin and ESR, serum adiponctin and IL - 6 and IL - 6 and ESR in NOA patients. This study illustrated change in the status of the inflammatory markers like adiponectin, IL - 6 and other parameters in NOA disease. It illustrated effect of some of the factors like age, gender, BMI, BMD, smoking habit and duration of disease on development of NOA disease and on the status of the parameters studied. Also this study illustrated some correlation between the parameters in NOA patients.
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