تقييم صحة الفم والبروتينات اللعابية لدى المرضى المصابين بمرض باركنسن == Assessment of The Oral Health And Saliva Proteins In Patients With Parkinsons Disease
Author name:
صباح فرحان مشتت
Supervisor name:
هاجر ابراهيم عبد الله | مروان صالح النمر
General topic:
Dentistry
Specific topic:
Oral and Maxillofacial Surgery
Degree:
Master
University:
Mustansiriyah University
Language:
English
University location:
Baghdad
First pages:
20T394 - p.pdf
Abstract:
Background : Parkinson's disease (PD) is a progressive neurodegenerative disorder related to the loss or absence of dopaminergic neurons in the brain. The deficits caused by PD result in slowness of movement, tremor, rigidity, and dysfunction of behavior and these symptoms negatively influence the patient’s capability to carry out the daily oral hygiene manoeuvres.Aims of study : This study aims at using saliva as a biological fluid for assessment in detecting the biomarkers of Parkinson's disease and to assess the impact of this disease on the oral health of patients.Materials and methods : A total number of fourty participants were involved in the study; twenty subjects who appeared healthy (Group I) and twenty Parkinson's patients (Group II). Patients who are eligible for this study were cases of Parkinson's disease treated with anti - Parkinson's medications, both genders and their ages ranged from 40 - 75 years. Specific information related to the demographic characteristics and illness is obtained from each patient. The Brain Bank Diagnostic Criteria for Parkinson’s disease established by United Kingdom Parkinson's Disease Society was used. Each patient was subjected to oral examination during which DMF index was scored, oral health impact Profile OHIP - 14 was used and from each participant the whole unstimulated saliva was collected for biochemical analysis including total salivary protein, direct determination of saliva proteins and determination of ? - synuclein. Results : many oral and clinical signs and symptoms elsewhere in the body were reported in the patient with Parkinson's disease while the clinical features of Parkinson's disease observed in all patients despite of their treatment. Static tremor observed in 100%, rigidity in 70%, disturbances in the autonomic nervous system reflected on the cardiovascular, gastrointestinal and urinary tracts, orthostatic dizziness observed in 75%, dry mouth in 65% difficulties in swallowing in 40% and constipation in 70%. Teeth examination revealed that Parkinson's patients have a non - significant high means of decay and missing teeth compared with healthy subjects. The total saliva protein in Parkinson's patients is significantly higher than the corresponding value of healthy subjects. The extinction coefficient of uncontaminated protein in Parkinson's patients is significantly less than the corresponding values of healthy subjects and salivary ? - synuclein level is significantly less in Parkinson's patients than healthy subjects.Conclusions : Salivary ? - synuclein may serves as a biomarker for Parkinson's disease. Specific protein with extinction coefficient 27.5 M.Cm - 1 is secreted in saliva of Parkinson's patients. The characteristic saliva protein produced in patients with Parkinson's disease is deficient in tyrosine level and Dental care is required for both groups (Parkinson's patients and healthy subjects).
