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دراسة فعالية نبات عين البزون كعلاج طبيعي لمرض سرطان الدم المستحث في ذكور الفئران Study the Activity of Catharanthus Roseus as Natural Treatment for Induced Leukemia in Male Mice

اسم المؤلف: محمد عبود عياش
الجامعة: جامعة بابل - كلية الطب
اسم المشرف: مفيد جليل عوض نسرين جلال محمد
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: Leukemia is cancer of blood - forming tissues, begin in the bone marrow characterized by highly elevated of abnormal proliferation and circulation of immature clonal hematopoietic cells. It can affect all ages around the world which in turn considered as one of public health problem.Plants considered as an important source for medical drugs manufacturing due to the presence of certain compounds with medicinal biological activity, therefore adopted in the preparation of a lot of medicines and medical drugs because of its' speed therapeutic influence and low of negative side effects which caused by chemically manufactured medications.The present study aimed to evaluate the activity and efficiency of vincristine and other important constituent in Catharanthus Roseus plant in treatment of leukemia through enhance and direct impact on some of the body's vital biological activities by using fresh crude plant as herbal medicine. This study is Cohort study design. It is monitoring, detection, and investigation study that included some of groups that completely under control; this study used in medicine, nursing, psychology and social sciences in addition to the Ecology. This study included (60) Albino male mice divided into four groups (15) mice for each. Group (A) was the control group, group (B) was mice feed orally with of C. Roseus plant, group (C) was leukemia induced mice by subcutaneous injection of (300mg/kg B.W benzene), and group (D) was Induced leukemia mice treated by oral feeding with C. Roseus plant. The experimental work was carried out in Clinical Biochemistry Department / College of Medicine / University of Babylon during the period from (October 2015 to August 2016).High - Performance Liquid Chromatography (HPLC) technique was used for measurement of Vincristine drug (VCR) in plant and vitamin D levels in mices' serum, Enzyme Linked Immunosorbent Assay (ELISA) had was used for the measurement of serum ferritin, UV - Vis Spectrophotometer was used for determination of GSH - Px and GST concentrations, while Graphite Furnace Atomic Absorption Spectrophotometer technique (GFAAS) was used for measurement of trace elements concentration of (Fe, Cu, Zn, Se). There were hematological and histopathology studies carried out by using special required equipment to make sure that leukemia disease was indeed occur.Hematological study included measurement of Hb levels and WBC count, while histopathology study included bone marrow, liver, kidney, spleen smear. Microscopic investigation for Chromosomal Aberration and Micronuclei were also had been done.Results showed that C. Roseus plant contain the concentration of vincristine drug up to 148μg/gm. There was highly significant increase of serum ferritin levels, GST activity, Iron and Copper concentration, and WBCs in leukemic group (C) (P<0.001) when compared with control group (A), while there were highly significant decrease of these parameters in group (B) as compared with the control (A) and (C) groups.Results also showed a highly significant decrease of GSH - Px activity, Vit.D levels, Zinc and Selenium concentration, and Hemoglobin levels in group (C) (P<0.001) when compared with the control group, while there were highly significant increase of these parameters in group (B) as compared with control and (C) groups. The present study found a positive correlation between Vit.D and GSH - Px activity, Ferritin and GST activity, while this study found a negative correlation between Ferritin and GSH - Px activity, serum Iron and Selenium concentration.The present study found positive effect of C.Roseus on abnormal parameters and support the biological system which was clear in group (D) which demonstrated that there were significant inhibitions to decrease or increase of these parameters than those in healthy control.
الصفحات الاولى:

علاقة مستوى فيتامين د والبوتين الدهني ا مع مقاومة الانسولين والعوامل الايضية الاخرى في داء السكري النوع الثاني في محافظة البصرة Relationship of vitamin D status and lipoprotein(a) levels with insulin resistance and other metabolic markers in type 2 diabetes mellitus in Basrah

اسم المؤلف: انوار يونس ابراهيم علي
الجامعة: جامعة البصرة - كلية الطب - قسم الكيمياء الحياتية
اسم المشرف: عبد القادر عبد الوهاب الشاكر
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2015
مكان الجامعة: البصرة
المستخلص: Diabetes Mellitus is a chronic metabolic disorder , caused persistent hyperglycemia resulting from defects in insulin production, insulin action or both.There are several evidence suggest that altered vitamin D and calcium homeostasis may play a role in the development of T2DM and IR .Lipoprotein(a) is a LDL - like particle consisting of Apo A moiety linked to one molecule of ApoB100 . Several studies revealed that Lp(a) may differentially affect in diabetic patient either increase or decrease or no change from normal range . It is not clear whether Lp(a) concentration is related to T2DM or associated with IR .Objectives : The present study was designed to measure vitamin D status and Lp(a) levels among patients with T2DM , to investigate association between serum 25(OH) D levels with IR , lipid profile and some metabolic factors and to demonstrate whether Lp(a) levels are linked to T2 DM. Methods and Materials : The present study included 80 patients with T 2 DM (30 male and 50female) with mean age (50.51± 10.70) year . Weigh, height, BMI were assessed for each participant . Fasting blood samples were collected to measure HbA1c% .Then another part of blood separated to get serum to measure [Vitamin D , Insulin , Lp(a) , FBS , Lipid profile , creatinine , calcium , phosphate] .Insulin resistance , Insulin sensitivity , β - cell function was calculated by homeostatic model assessment ( HOMA - IR) , (HOMA - IS) and (HOMA - %β ) respectively .Results : The result of this study revealed that serum vitamin D among diabetic patients with a mean (19.94 ± 9.59) ng/ml . Frequency of vitamin D deficiency [s.25(OH)D > 20 ng/ml ] was (52.5%) , Only (12.5%) of diabetic patients had normal levels of vitamin D [s.25(OH)D≥ 30 ng /ml] . Thirty five percent of patients with vitamin D insufficiency [s.25(OH)D = 20 - 29.9 ng /ml ] .Vitamin D among diabetic patients of the present study showed an inverse relationship with BMI , HOMA - IR, insulin , HbA1c, TG , VLDL - c, age statistically significant independent , But positive significant independent association with HOMA - IS , HDL - c and statistically significant not independent associated with FBS, HOMA - %β). No significant associated with other biochemical parameters . Regarding to the levels of Lipoprotein (a) levels among diabetic patients found with a mean (7.93± 5.34) mg/dl and no significant association with glycemic profile (FBS,HbA1c, insulin , HOMA - IR, HOMA - IS , HOMA - %β ) or lipid profile .Conclusion : The decline in the level of vitamin D among diabetic subject may affect glucose homeostasis . In addition to that hypovitaminosis D could be rising with increase BMI and obesity among diabetic subjects , BMI is positively associated with insulin resistance . Serum 25(OH)D among diabetic subject is negatively with insulin resistance . Therefore vitamin D deficiency may contribute to onset of IR and development of T2DM. Regarding to Lipoprotein (a) levels among the majority of diabetic patients were within normal range (≤ 30 mg/dl) and it was noted that the Lp(a) levels were not related to IR or T2DM . In addition to that there is no interference between levels of vitamin D and p(a) levels with respect to IR .
الصفحات الاولى:

دراسة مستوى بعض العوامل المؤكسدة والمضادة للتاكسد في مرضى اللوكيميا وسرطان الثدى Profile study of some oxidant and antioxidant levels in leukemic and breast cancer patients

اسم المؤلف: نهاية مناحي العبودي
الجامعة: جامعة البصرة - كلية الطب
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2004
مكان الجامعة: البصرة
المستخلص: This study was carried out to evaluate the oxidant and antioxidant level in cancer patients in Basrah during the period from the first of October 2002 till the end of April of the 2003. A total of 98 patients were investigated, who were admitted to the Basrah General Hospital, Teaching Hospital and Basrah Hospital for Maternity and Pediatric in Basrah City. They were 52 female patients with breast cancer and 46 leukemic patients (24 male and 22 female). In addition 125 sex and age - matched persons without malignancy served as controls. They were 64 persons as control for leukemic patients (32 male and 32 female) and 61 females as control for breast cancer patients. The haematological parameters measured were haemoglobin concentration(Hb), packed cell volume (PCV) value and white blood cell (WBC) count, while the biochemical parameters measured were glutathione (GSH) level, uric acid, malondialdehyde (MDA) and phagocytic activity . The leukemic patients were subclassified into two groups according to their age (30 patients ≤16 years and 16 patients >16 years). The breast cancer patients were subclassified into three groups according to their age (11 females as 25 - 34 years old, 17 females as 35 - 44 years old and 24 females as ≥45 years old). The Hb concentration and PCV value were significantly decreased (P<0.05) in leukemic patients of age group 16 years old ,however, in age group > 16 years old ,the decrease were extremely significant (P<0.001). In breast cancer patients the Hb concentration decreased extremely significantly in all age groups (P<0.001). A highly significant decrease was found in PCV value of age group 35 - 44years old (P<0.01), whereas a significant decrease in 25 - 34 years and  45 years age groups (P<0.05) was observed. The WBC count in leukemic patients showed an increase in WBC count significantly in 16 years old age group (P<0.05) and extremely significant increase in >16 years old age group (P<0.001). In breast cancer the WBC count showed decrease in WBC count significantly in 25 - years old patients (P<0.05), highly significant decrease in 35 - years old patient (P<0.01) and extremely significant decrease in 45 years old patients (P<0.001). There were no significant differenses in Hb concentration, PCV value and WBC count between male and female leukemic patients. The biochemical investigation showed an extremely significant depletion in GSH levels in leukemic and breast cancer patients (P<0.001). The phagocytic activity was extremely significantly decreased in all leukemic patients (P<0.001) and highly significant increase in 25 - 34 years old breast cancer patients (P<0.01), significantly increase in 35 - 44 years old breast cancer patients (P<0.05) and extremely significant increase in  45 years old breast cancer patients (P<0.001). There was no significant difference between male and female leukemic patients in phagocytic activity. The MDA level was highly significantly increased in 16 years old leukemic patients (P<0.01) and extremely significant in >16 years old leukemic patients (P<0.001). In breast cancer the MDA level was highly significant increase in all age groups patients (P<0.01). The investigation of uric acid concentration shows extremely significant increase in all leukemic patients (P<0.001) and highly significance increase in 25 - 34 years old and 35 - 44 years old breast cancer patients (P<0.01). Also shows extremely significant increase in 45 years old breast cancer patients (P<0.001). In conclusion, cancer patients suffer a high degree of ROS formation causing considerable oxidative stress which associated with decrease glutathione level and significant degree of lipid peroxidation.
الصفحات الاولى:

نمط اكسدة الدهنيات ومستوى العوامل المضادة للاكسدة لدى مرضى السكري

اسم المؤلف: اماني نعمة الرمضان
الجامعة: جامعة البصرة - كلية الطب
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2002
مكان الجامعة: البصرة
المستخلص: تم شمول 40 مريضا من مرضى داء البيلة السكري الخاضعين للعلاج بالانسولين، و60 مريضا من المرضى غير الخاضعين للعلاج بالانسولين، و94 شخصا من الاصحاء في هذه الدراسة. وقد تم اخذ المعلومات من جميع المشاركين في هذه الدراسة (حسب الملحق المرفق رقم 1). اجريت التحاليل التالية للمجاميع الثلاثية : مستوى جلوكوز الدم، الهيموكلوبين السكري، مستوى فيتامين ج المصلي، نسبة المالدنداي الدهايد، مستوى الكولسترول الكلي، مستوى كولسترول البروتينات الدهنية ذات الكثافة العالية، مستوى كولسترول البروتينات الدهنية ذات الكثافة الواطئة، مستوى كولسترول البروتينات الدهنية ذات الكثافة الواطئة جدا، مستوى الشحوم الثلاثية، بالاضافة الى قياس مستوى البروتينات الدهنية الابو - ا ، وكذلك مستوى البروتينات الدهنية الابو - ب. وقد اظهرت الدراسة مايلي : - ان المرضى المصابين بداء البيلة السكري (كلتا المجموعتين، الخاضعين غير الخاضعين للعلاج بالانسولين) كانوا على درجة من السوء فيما يخص السيطرة على تمثيل السكر في الدم عند مقارنتهم بالاشخاص الاصحاء . وذلك يتمثل بالنتائج التالية : ا - قيمة الهيموكلوبين السكري السكري لدى المرضى المصابين بداء البيلة السكري (الخاضعين والغير خاضعين للعلاج بالانسولين) كانت (62ر9  22ر2%) ، (1ر9  8ر2%) على التوالي ، بينما كانت النسبة لدى الاشخاص الاصحاء (9ر4  6ر0%) . ب‌ - المؤشر الثاني لسوء السيطرة على هذا المرضى عند الاشخاص المصابين، هو ارتفاع مستوى جلوكوز الدم في كلتا المجموعتين (المرضى الخاضعين للعلاج بالانسولين والغير خاضعين) عند مقارنتهم بالاشخاص الاصحاء ، حيث كانت النتائج كما يلي : - (3ر218 3ر98 ملغم / 100 مل) و(200 96 ملغم / 100 مل) على التوالي ، بينما كانت نسبة الجلوكوز لدى الاشخاص الاصحاء (6ر90  6ر14 ملغم / 100 مل) * فيما يتعلق بالعوامل المضادة للاكسدة والتي اشتملت الدراسة على قياس احداها (قياس مستوى فيتامين ج المصلي) ، قد لوحظ ما يلي : - - تدني معنوي في مستوى فيتامين ج المصلي لدى الاشخاص المصابين (الخاضعين والغير خاضعين للعلاج بالانسولين) فيتامين ج المصلي عند الاشخاص المصابين الخاضعين للعلاج بالانسولين (40ر1  45ر0 ملغم / 100 مل) ، وعند الاشخاص المصابين الغير خاضعين للعلاج بالانسولين (1ر1  45ر0 ملغم / 100مل) مقارنا بمستوى هذا الفيتامين لدى الاشخاص الاصحاء (4ر1  5ر0 ملغم / 100 مل) . - عند المجاميع الثلاثة المشاركة في هذه الدارسة ، لوحظ ان هنالك ترابط عكسي بين تركيز فيتامين ج المصلي مع كل من : - مستوى المالدناي الديهايد (0.242 = r وp< 0.001) ، الهيموكلوبين السكري (036 r ، p<0.001) ، كدلسترول البروتينات الدهنية ذات الكثافة الواطئة (r=0.21 ، p<001)، كدلسترول البروتينات الدهنية ذات الكثافة الواطئة جدا (r = 0.22 ، p<0.001) ، الشحوم الثلاثية (r =0.26 ، p<0.0001 ، الكولسترول الكلي (r = 0.23 ، p<0.001) . * اكسدة الدهينات (والتي تمثلت بقياس مستوى المالدنداي المصلي) قد اظهرت زيادة معنوية لدى الاشخاص المصابين الخاضعين والغير خاضعين للعلاج لدى الاشخاص المصابين الخاضعين والغير خاضعين للعلاج بالانسولين (1ر1  39ر5 مايكرومول / لتر و09ر1  28ر0 مايكرومول/لتر على ، p<0.001) مقارنة بالاشخاص الاصحاء (55ر0  23ر0 مايكرومول / لتر) . - وقد تبين في هذه الدراسة ايضا ان هناك ترابط عكسي بين مستوى المالونداي الديهايد المصلي مع مستوى فيتامين ج المصلي ، وكذلك مع مستوى كولسترول البروتينات الدهنية العالية الكثافة (r=0.24 ، p<0.001) ، (r=0.28 ، p<0.0001) على التوالي ، بينما وجد ان هناك ترابط طردي بين مستوى المالدنداي الديهايد المصلي ونسبة الهيموكلوبين السكري (r=0.54 ، p<0.0001) ، كذلك ترابط طردي مع مستوى الشحوم والبروتينات الدهنية ، مع كل من : - كولسترول البروتينات الدهنية ذات الكثافة الواطئة ( r = 0.54 ، p<0.0001) ، كولسترول البروتينات الدهنية ذات الكثافة الواطئة جدا ( r =0.44 ، p<0.0001) ، الشحوم الثلاثية (r =0.48 ، p<0.0001 ) ، الكولسترول الكلي (r=0.50 ، p<0.0001) . * في جميع الفئات العمرية للمرضى ، ظهر ارتفاع معنوي في مستوى الكولسترول الكلي ، والبروتينات الدهنية ذات الكثافة الواطئة جدا مقارنة بالاصحاء لتلك الفئات العمرية . وقد لوحظ في الفئة العمرية من عمر 25 - 45 سنة (لدى المرضى الخاضعين للعلاج بالانسولين) بان الزيادة في الكولسترول الكلي والبروتينات الدهنية ذات الكثافة الواطئة كانت زيادة غير مهمة معنويا . - مستوى البروتيات الدهنية ذات الكثافة العالية في مصل الدم كان اقل لدى جميع الفئات العمرية للمرضى مقارنة بالاصحاء لتلك الفئات العمرية ، اما في المجموعة العمرية البالغة اقل من 25 سنة (للمرضى الخاضعين للعلاج بالانسولين) كان هذا النقصان مهم معنويا . * وقد اظهرت هذه الدراسة ايضا ، ان مستوى البروتينات الدهنية الابو - ا في مصل الدم وفي جميع الفئات العمرية للمرضى كان اقل معنويا مقارنة بالاصحاء لتلك الفئات العمرية ، بينما كان هناك زيادة حادة في مستوى البروتينات الدهنية الابو - ب المصلي في جميع الفئات العمرية للمرضى مقارنة بالاصحاء . | Fourty patients with insulin dependent (IDDM), 60 with non insulin dependent diabetes mellitus (NIDDM) and 94 apparently healthy control subjects were included in this study. The following parameters were estimated : fasting serum glucose, glycosylated hemoglobin (HbA1c), serum vitamin C, serum malondialdehyde (MDA), S.cholesterol, HDL - C, LDL - C, VLDL - C, TG, Apo - A, Apo - B. The study has shown that : Diabetic patients (both IDDM and NIDDM) have significant poor metabolic control as compared with control subjects as their a) Hb A1c% was (9.622.22) and (9.12.8) respectively, while in control subjects HbA1c% was (4.90.6). b) FBG was (218.398.3mg/dl) and (20096mg/l) respectively, while in the control subjects FBG was (90.614.6mg%). Regarding the antioxidant status (as measured by estimating serum vitamin C) a low serum vitamin C was observed in both diabetic groups (IDDM and NIDDM) as compared with control group and this result was highly significant. The mean serum vitamin C level in IDDM and NIDDM diabetic patients was (1.040.45mg/dl) (1.100.54mg/dl) respectively in comparison to (1.40.5mg/dl) in the control group. In all individuals studied, there was a significant negative correlation between serum vitamin C and the following parameters, S.MDA (r=0.242, P<0.001), HbA1c (r=0.365, P<0.001), LDL - C (r=0.214, P<0.001), VLDL - C (r=0.228, P<0.001), TG (r=0.265 , P<0.0001), TC (r=0.234, P<0.001). Lipid peroxidation (as measured by estimating serum malondialdehyde) was significantly elevated in diabetic patients both IDDM and NIDDM (1.100.39 mol/L and 1.090.28mol/L respectively, P<0.001) as compared with controls (0.550.23 mol/L). The study has illustrated also a negative correlations between S.MDA level and S.vitamin C level, as well as with HDL - C level (r=0.242, P<0.001), (r=0.285, P<0.0001) respectively. In addition there was a positive correlation between S.MDA level and HbA1c level (r=0.541, P<0.0001), as well as, a positive correlation with serum lipids as follows : LDL - C (r=0.549, P<0.0001), VLDL - C (r=0.449, P<0.0001), TG (r=0.484, P<0.0001), TC (r=0.509, P<0.0001). Serum lipids, TC, LDL - C, TG and VLDL - C levels were significantly increased in diabetic patients in all age group as compared with control - subjects. While in the IDDM at the age group (25 - 45 years), the elevation of serum levels of TC, LDL - C were statistically not significant . Serum HDL - C level was decreased in all age groups of diabetic patients as compared with control subjects. In the age group of <25 years , the decrease in the HDL - C level was statistically significant. In addition, serum Apo - A level was significantly lower among diabetic patients (IDDM and NIDDM) for all age groups compared to the respective age groups in control subjects. While serum Apo - B level was significantly higher among diabetic patients (IDDM and NIDDM) for all age groups compared to the respective age groups in control subjects.
الصفحات الاولى:

تقيم معارف العناية الذاتية للمرضى المصابين بداء السكري النوع الثاني في مركز السكري في محافظة بابل Assessment Of Self - Care Knowledge Among Type II Diabetes Mellitus Patients At Diabetic Center In Babylon Governorate

اسم المؤلف: سالم كريم هجول الجبوري
الجامعة: جامعة بابل - كلية التمريض
اسم المشرف: سلمى كاظم جهاد
الموضوع العام: الطب
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بابل
المستخلص: اجريت دراسة وصفية (عرضيه مقطعيه) للفترة من 20/10/2015 ولغاية 25/6/2016 من اجل تقييم معارف الرعاية الذاتية لمرضى السكري النوع الثاني في مركز السكري في محافظة بابل. وقد اختيرت عينة هادفة من (120) مريضا باستخدام تقنية اخذ العينات غير الاحتمالية، التي تشمل ا | A descriptive design cross - sectional study has conducted throughout the period of October 20th 2015 to June 25th 2016 in order to assess the self - care knowledge of patients with type II diabetics mellitus at diabetic center in Babylon Governorate. A Purposive sample of (120) subjects were selected throughout the use of non - probability sampling approach, that include patients who were diagnosed with type II diabetes mellitus visiting diabetic center in Merjan medical city/ Babylon Governorate. A questionnaire was constructed to achieve the objectives of the present study, comprised of four domains including (50) items. Data was collected from patients attending for or treatment diabetic center in Hilla city through the use of interview technique, during the duty shift for the purpose of receiving health care, each patients' individually interviewed, helped by the researcher and taking a corresponded period of between ( 20 - 25) minutes. The questionnaire was clear and adequate for the measurement of the phenomenon except some adjustments are made on few items according to the experts' suggestions.Reliability of the questionnaire was determined through a pilot study and the validity was achieved through a panel of (16) experts. Data were analyzed through use of the Statistical Package of Social Sciences (SPSS, Version 20). Reliability was concerned with the consistency and dependability of the research instrument. Determination of internal consistency, reliability of the questionnaire is based on computation of Alpha Cronbach's Correlation Coefficient.The findings of the study indicated that Type II diabetes mellitus age group have old age. Sample less opportunity to read and write.Results of the diabetes mellitus patients demonstrated that sample acceptable level of socio - economic status. Regarding residency it was shown that most Diabetes mellitus type II patients existed in urban areas. study sample was found to score body mass index of overweight feature. Fortunately participants showed a good knowledge about the diabetes mellitus and its complications. In regard to knowledge of sample about self - care it was demonstrated that their achievements were fine. Self - care in diabetes has been defined as an evolutionary process of development of knowledge or awareness by learning to survive with the complex nature of the diabetes in a social context. The recent study summarized that some dietary behaviors need more attention from the patient to regulate and balance the condition, It is interesting to find out that sample study had reached good scores in regard to different issues of self - care except with some exercises and activities related to foot care. As well as current study concluded that Patients' age, levels of education, family history of diabetes and marital status affect their knowledge level as overall. The study recommended that. Patients with chronic diseases like the current one need to be educated in regard to some misconceptions such as treatment of the illness, Although majority of patients know the signs and symptoms of disease, health care facility can help in emphasizing the lack of information in some areas of the subject, Some self - care results show deficits concerning the diet, appropriate strategies such as give priorities to those very vital factors in controlling blood sugar when teaching patients can be used to correct the patients dietary habits. Educational materials or programs designed to assist Patients in practicing some activities to reduce burden of the condition.
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العوامل المؤثرة على نوعية حياة المرضى المصابين بالجلطة الدماغية في مركز الفرات الاوسط للعلوم العصبية في مدينة النجف الاشرف Factors Affecting Quality Of Life For Patients With Cerebrovascular Accident In Middle Euphrates Neuroscience Center In Al - Najaf Al - Ashraf City

اسم المؤلف: احمد صالح رضا القاضي
الجامعة: جامعة بابل - كلية التمريض
اسم المشرف: سحر ادهم علي
الموضوع العام: الطب
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بابل
المستخلص: خلفية الدراسة : تعتبر الجلطة الدماغية سبب رئيسي مؤثر يقلل مستوى نوعية حياة المرضى. قياس نوعية الحياة للاشخاص الذين يعانون من امراض مزمنة يعطي رؤية واضحة لتحديد اثره على مقدمي الرعاية الصحية عندما تكون النتيجة غير ممكنه. العوامل المؤثرة على نوعية الحياة لم | Background : Cerebrovascular accident is a main leading cause affectedly decrease the level of quality of life of the patients. The measurement of quality of life for population with chronic diseases gives a clear view to determine the impact on health care providers when prognosis is not possible. Factors affecting the quality of life may be vary between different age categorize such as CVA young and old CVA patients, different factors have affected the quality of life, related to the following aspects : motor impairment, physical dysfunction or dependency in activity of daily living, the presence of depression ,cognitive impairment, and speech disturbances.The main aim of the study : To identify the factors affecting the quality of life for patients suffering from cerebrovascular accident.Design of the study : Descriptive cross - sectional study design was selected to achieve the objectives of this study the factors affecting quality of life for patients diagnosed with cerebrovascular accident in Middle Euphrates Neuroscience center in Al - Najaf Al - Ashraf City, for the period between 27 October 2015 and 30 August 2016.Setting : A unique center was selected to conduct the study, the outpatient department in Middle Euphrates Neuroscience center in Al Najaf Al Ashraf City are used to collect the data.Sample of the study : Non probability ( purposive sample ) from patients with CVA (N=80) were selected to find out the factors affecting quality of life for patients with cerebral vascular accident. Data was collected by using an assessment questionnaire which was adopted and developed by the researcher to assess the factors affecting the quality of life for patients with cerebrovascular accident. It is divided of three parts : demographical data as the first part, clinical information is the second part, while the specific CVA quality of life questionnaire which extended to 48 items distributed upon 12 main domains as (energy and activity, family relationship, speaking, movement, mood, personality, self - care, social role, thinking, in addition upper extremities functions, vision, and work / productive ) is the third part. Validity of the questionnaire obtain by (19) experts, who work in different fields to obtain the reability of the questionnaire alpha cronbach was used as a statistical method.The majority of the study sample were between (59 - 69) of age. The highest percentage of the study sample were males and were married. On the other hand the highest percentage of the sample were illiterate , housewives and urban area residents. The scores of the quality of life of the majority of the study sample were high effected regarding the following domains : (energy and activity), plus movement, moderate effect presented related to the family relationship, speaking, mood, self - management, social role, thinking, function of the upper extremities, vision, and job / productive, while low effect score recorded for personality.Conclusion : The overall quality of life level of the CVA patient who participate in the study was moderate. The QOL for patient with CVA were significantly effected related to their age, occupation, and educational level. Chronic diseases, type of CVA and it's duration play as highly effecting factors related to the patient's quality of life.Recommendation : Establishing structured program realizing the challenges that might face the post CVA patients because this long journey need special planned care to improve patient's quality of life by special rehabilitation unit, the unit services may be extended for the patient's family.
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الانماط الجينية والبروتين الرابط للرتينول 4 في مرضى الاعتلال الكلوي السكري النوع الثاني Gene Polymorphism And Retinol Binding Protein 4 In Type 2 Diabetic Nephropathy Patients

اسم المؤلف: احمد جبار عباس
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اسم المشرف: مها فاضل سميسم علاء حسين ال حيدر
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: داء السكري هو مرض ايضي له تاثير على ايض الكاربوهيدرات والدهون والبروتينات. ومن مضاعفات السكري اعتلال الكلية السكري، الذي يعد السبب الرئيسي للفشل الكلوي المزمن. الليبوكالينات هي عائلة من البروتينات التي تنقل الجزيئات الكارهة للماء صغيرة مثل السروئيدات | Diabetes mellitus (DM) is a metabolic disease involving carbohydrate, lipid, and protein metabolism. Diabetic nephropathy (DN) is the significant complication of diabetes, which is at the present time the major cause of chronic renal failure. The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, retinoids, and lipids. Retinol binding protein 4 (RBP 4) is a member of the lipocalin family of proteins and it has a role in insulin resistance. A meta - analysis demonstrated a significant association between the polymorphism of glucose transporter1 gene with DN. The presence of endothelial nitric oxide synthase (eNOS) polymorphisms may contribute to a decreased eNOS activity and a lowered nitric oxide level, and has been reported to be a potential factor in the development and pathogenesis of DN. The study aimed the evaluation of lipid profiles and determination of their association with retinol binding protein 4 expression in diabetic patients, evaluation of gene expression of eNOS G894T polymorphism in diabetic patients to predict its relationship with nephropathy in future, and evaluation of gene level of GluT1 polymorphism in diabetic patients to predict its relationship with nephropathy in future. This study was conducted in Hilla city, from December 2015 to April 2016. The samples were collected from Babylon Center for Diabetes and Endocrinology in Marjan Teaching Hospital in Babylon / Hilla city.This study was included 160 subjects, who were (35 - 58) years old and BMI between (25 - 29.9) which were divided into groups : Control group 80 apparently healthy persons included 40 male control group (MC) and 40 females control group (FC). Eighty patients with diabetes mellitus type 2 include (40 males group (M)) and (40 females group (F)). Blood samples (10 ml) were taken from fasting subjects. Two milliliters of blood were put in EDTA tube used for the determination of HbA1c and genetic study and 8 milliliters of blood were put in plane tube and centrifuged to separated serum to measure (glucose, insulin, retinol binding protein 4 and lipid profile ( and insulin resistance was measured by equations. The results show : 1. There is a significant increase in the mean of fasting glucose, HbA1c, fasting insulin level, insulin resistance in groups M and F as compared to the control groups, (p<0.01), but there was no significant increase between two patient groups (p ? 0.05)2. The significant increase (P <0.01) in total cholesterol (TC), TG, LDL - C and VLDL - C, while serum HDL - C concentration was found significantly decrease (P<0.01) in patient groups as compared with the control groups, and no significant increase or decrease in lipid profiles in comparison between patients groups (P ? 0.05).3. There is significant increase (P< 0.01) in RBP4 between patients and control groups, and not significant (P?0.05) difference between patient groups.4. Group M shows significant positive correlations (r = 0.514, p= 0.0012 and r = 0.536, p = 0.0034) of RBP4 concentration with serum fasting insulin concentration and HOMA - IR respectively, in group F, the results show a significantly positive correlation (r = 0.502, p = 0.001 and r = 0.474, p = 0.02) between RBP4 concentration with serum fasting insulin concentration and HOMA - IR respectively.5. A significant positive correlations was found (r = 0.486, p 0.001; r = 0.388, p 0.013; r =0.385, p=0.014) for serum RBP4 concentration with TC, TG and LDL - C concentrations respectively, and significantly negative with HDL - C (r = - 0.424, p =0.006) in group M, also positive correlation (r = 0.443, p =0.004; r = 0.467, p = 0.002; r = 0.435, p = 0.005) of RBP4 with TC, TG, LDL - C respectively and negatively with HDL - C (r = - 0.453, P = 0.003) in group F.6. A significant increase (< 0.01) in non HDL - C between patients and control groups and no significant (?0.05) difference between patient groups.7. According to the results of genotyping, XbaI polymorphism wasidentified as homologous genotype XbaI ( - / - ) were 12 (30%) in the group M, 14 (35%) in the group F, 3(7.5%) in the group MC and in the group FC 2(5%), while individuals have heterozygous genotype XbaI ( - /+) were 7 (17.5%) in the group M, 10 (25%) in the group F, 10 (25%) in group MC and in the group FC 8(20%).8. A significant association between the frequency of XbaI ( - / - ) variant in group M in compared with group MC an odd ratio = 5.14 and confidence interval at 95% level of (1.36 - 19.4), and in group F in compared with group FC an odds ratio = 13.12 and confidence interval at 95% of (2.64 - 65.07). 9. According to the results of genotyping, G894T polymorphism for eNOS gene was identified as homologous genotype TT were 7 (17.5%) in group M, 9 (22.5%) in group F, 8 (20%) in group MC and 10 (25%) in group FC, while individuals have heterozygous genotype G/T were 21 (52.5%) in group M, 20 (50%) in group F, 6 (15%) in group MC and 7 (17.5%) in group FC.10. A significant frequency of GT variant in group M is compared with group MC with odds ratio = 7.58 and confidence at 95% level of (2.43 - 23.62), and in patients of group F as compared with group FC with odds ratio = 7.27 and confidence interval at 95% of (2.4 - 22.02).In conclusion, the RBP4 is associated in causing insulin resistance and lipid abnormalities. The high levels of Non HDL - C in diabetic patient contribute in progression of diabetic nephropathy. The GLUT1 polymorphism in diabetic type 2 patients specially patients with XbaI ( - / - ) and eNOS gene polymorphism G/T allele have a role in progression to diabetic nephropathy.
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قياس تركيز الحديد والفرتين والارثروبويتين وفيتامين ب وحامض الفولك والبيروكسايديز الدرقي في مصل مرضى تضخم الغدة الدرقية حديثي التشخيص في محافظة بابل Serum Iron,Ferritin,Thyroid Peroxidase ,B12,Erythropoietin And Folate Concentrations In Patients With Newly Diagnosed Hyperthyroidism In Babylon Province

اسم المؤلف: سالينا عبد العباس ناصر الشمري
الجامعة: جامعة بابل - كلية التمريض - قسم الفسلجة والفيزياء الطبية
اسم المشرف: محمد عبيد المحمدي علاء صادق العواد
الموضوع العام: الطب
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بابل
المستخلص: فرط نشاط الغده الدرقيه : هو مرض يصيب الغده الدرقيه وذلك نظرا لارتفاع هرمون تي ثلاثه وتي اربعه وهما هرمونات الدرقيه ولوحظ ان هذا المرض يصيب النساء بنسبه اعلى من الرجال بسبب التاثير الهرموني للاناث مما يجعلها الاكثر عرضه لهذا المرض,من علامات هذا المرض هي زيا | Background : Hyperthyroidism is endocrine disease that occur due to high levels of thyroid gland hormones and this disease affected female more than male due to hormonal effect, the female is more susceptible to this disease.Sign of disease including increase in metabolic rate of patient,sweating,increase pulse,enlargement of thyroid gland(goiter) which by this sign can diagnosis the patient.Objective : Evaluate serum erythropoietin and its relation with increase metabolic rate as well as hemopoiesis,evaluate serum folic acid and vitamin B12 and its role in hyperthyroidism ,evaluate the correlation of thyroid peroxidase with thyroid hormones and evaluate serum iron and ferritin.Materials and methods : This study was done from October/2015 till July/2016.The total number of patients group in this study was seventy man and women.their age ranged 26 - 65 years,58 women and 12 men who was in patients group and 35 female and 5 male in control group.Patients data in this study was history of hypertension ,parity ,age and sex. The difficulty in my research was in collection of spa icemen from patients.Result : The result which obtained from this study found that high significant increase in ferritin,thyroid peroxidase,folate and erythropoietin (p?0.01) in patients as compare to control group.High significant decrease in iron and B12(p?0.01) in patients group compare to control group. in case of the age found the 30 - 39 years more effected age among patients group and the female more effected with disease than male.Conclusion : From this study we conclude that thehyperthyroidism in female more than male due to hormonal effect. Reduce in iron due to high metabolic rate lead to decrease absorption of iron and B12 which lead to anemia.increase thyroid peroxidase which play a role in T3 and T4 synthesis.
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التزام مرضى احتشاء العضلة القلبية باتجاه العناية الذاتية في مستشفيات الحلة التعليمية Adherence Of Patients With Myocardial Infarction Toward Self - Care Management In Hillah Teaching Hospitals

اسم المؤلف: هادي جواد كاظم
الجامعة: جامعة بابل - كلية التمريض
اسم المشرف: سحر ادهم علي
الموضوع العام: الطب
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: يمكن وصف العناية الذاتية كبرنامج متعدد الابعاد للمرضى الذين يعانون من احتشاء عضلة القلب والتي تشمل الامور المتعلقة بحالتهم وتعزيز استراتيجيات الرعاية الذاتية مثل المراقبة الذاتية والتصرفات الذاتية تحسين معرقة المريض الايجابية واستهلاك نظام غذائي صحي، الاد | Self - management can be described as multidimensional program for patients with myocardial infarctions which include improvement of the patient s knowledge related to their condition and enhance self - care management strategies such as self - monitoring, positive self - behaviors, and consumption of healthy diet, medication and following the health team advices. This strategies decrease hospital readmissions and improve quality of life. The aim of the study is assessing the adherence of self - care management among patients with myocardial infarction. To identify the demographical characteristics of the study sample such as (age, gender, marital status, educational status, and addressing, economic status). To find out the relationship between patient adherence of self - management and demographic data (age, gender, marital status, educational status, addressing, economic status) and clinical characteristics.Across - sectional descriptive design is used to carry out the study of assessing the adherence of the self - care management for patients with myocardial infarction in Hillah teaching hospitals from 27 - 10 - 2015 to 20 - 8 - 2016.Coronary care units and medical wards in two teaching hospitals in Hillah city were selected to conduct the study. A Non - Probability (purposive sample) of (100) patients, (64) male, (36) female have been selected after obtaining their agreements to participate in this study, these patients have been admitted to the medical wards or coronary care units. Data were collected by using structured questionnaire which prepared to assess the adherence of self - care management for patients with myocardial infarctions after a comprehensive review of related literatures. The questionnaire contains three parts, the first part consist data related to the socio - demographical characteristics of the sample, the second part includes clinical information such as (duration of disease, health history, body mass index...etc.), while the third part extends to collect the data related to the patients adherence toward self - care management which distributed up on (4) domains consisting nutritional domain (27) items, healthy behaviors (7) items, medications (8) items, medical follow up which has been extended to (9) items. Data have been collected by using face to face interview.To test the content validity the questionnaire distributed among (25) experts who have not less than 10 years of experience , the reliability was calculated through applying coefficient of correlation and inter rater reliability, descriptive and inferential statistics methods used to determine the results of the current study.The majority of the study sample have been (64%) male between (60 years and more) age group, (64) married, (22%) have been illiterate, (66%)of the sample urban area residency. housewives Most of them (25%) suffer from hypertension as a chronic disease. Overall adherences of the self - care management of the participant poor related to diet, healthy behaviors, follow up while they recorded moderate adherence related to consumption of medication.The majority of the patients who participate in the study were with moderate adherence relation to self - care management.Establishment of well - equipped rehabilitation center specialized to improve patient's knowledge and practices related to their conditions, and help them to live with their condition, the services of this center may be extended to serve patient's family.
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اعباء رعاية الابوين للاطفال المصابين بالتخلف العقلي في محافظات الفرات الاوسط Parents Burden Of Care For Children With Mental Retardation In The Middle Euphrates Governorates

اسم المؤلف: علوان حسن رزن الجبوري
الجامعة: جامعة بابل - كلية التمريض
اسم المشرف: سجاء هاشم محمد الربيعي
الموضوع العام: الطب
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: يمكن ان تسهم مسؤولية رعاية الاطفال المتخلفين عقليا في عبا على الوالدين, الدراسة تشير الى ان اباء الاطفال الذين يعانون من التخلف العقلي لديهم مستوى عال من العبء.دراسة تحليلية وصفيه لتقييم عبء رعاية الاباء للاطفال ذوي التخلف العقلي في محافظات الفرات الاوسط | The responsibility of caring for mentally retarded child can contribute to parents burden. The study shows that parents of children with mental retardation experience high level of burden.The present study aims to assess the level of burden of care among parents who have children with mental retardation.and to identify the relationship between parents burden of care for children with mental retardation and their sociodemographic data such as age, gender etc. A descriptive - analytical study design is conducted to assess the Parents Burden of Care For Children With Mental Retardation in The Middle Euphrates Governorates and its relation to children and parent's sociodemographic characteristics and clinical characteristic of mental retardation child.1st October 2015 to 1st October 2016. A purposive (non - probability) sample of (90) parents (mother or father) of child with mental retardation are selected attending mental disability care institute. Data was collected through the use of The questionnaire which are constructed by the researcher for the purpose of present study. In order to test the validity of the questionnaires, the instrument is presented to panel of experts in different fields to make it more valid. A preliminary copy of the questionnaire is displayed to (15) experts. Data have been analyzed by using descriptive and inferential statistics.The results of the study indicated that parents exhibit high level of burden due to the handicap caring among their children. There is a significant relationship between the levels of parents' burdens and their child handicap degree and the monthly income. As for the psychological status there are significant differences between the psychological burden and the parents level of education and residency. But there is non - significant statistical points between the parents burden and other parents demographical data.The study concludes that there is a high level of parents burden due to the presence of mental retardation child in the family and that effect on the family. The degree of mental retardation is very important indication about the level of the burden.It is recommended that future study researches should be directed towards exploring psychological intervention factors which help to minimize the burden of care on parents of children with mental retardation.
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المشكلات النفسية الاجتماعية لدى كبار السن في دور رعاية المسنين في محافظات الفرات الاوسط Psychosocial Problems Among Elderly People At Geriatric Homes In The Middle Euphrates Governorates

اسم المؤلف: وسيم عبد الامير شاكر البصام
الجامعة: جامعة بابل - كلية التمريض
اسم المشرف: سجاء هاشم محمد الربيعي
الموضوع العام: الطب
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: اجريت دراسة وصفية تحليلية خلال المدة من الاول من تشرين الاول من عام 2015 الى تشرين الاول 2016 من اجل تقييم المشكلات النفسية الاجتماعية لدى كبار السن في دور رعاية المسنين في محافظات الفرات الاوسط.عينة غرضية (غير احتمالية) تتالف من (82) شخص مسن قد تم اختيا | Analytical descriptive study was conducted during the period of 1 October 2015 to October 2016 in order to assess the psychosocial problems among elderly people at geriatric homes in the Middle Euphrates Governorates. A purposive sample (non - probability) for (82) elderly people was selected from geriatric homes in the Middle Euphrates Governorates, information was gathered through the use of a questionnaire for assessing psychosocial problems, study tool consist of three parts which contain (53) items. Part one : The first part consists personal information and include age (year) , age at admission, residence years in geriatric homes, gender, previous professions, educational level, social status, economic status, financial support by family, the financial resources.Part two : The second part consists psychological problems (anxiety, depression and suicide ideation) which contains (35) item. Part three : The third part consists social problems (social isolation) which contains (12) item. Reliability is determined by using alpha correlation (Cronbach's Alpha) and the validity is achieved through a panel of (21) expert. Data analyzed through using the Statistical Package of Social Sciences SPSS (Version 20) performed through the use of descriptive statistical data analysis approach, of frequencies, percentages and inferential statistical approach which is presented as an analysis of variable chi - square.The findings of the study indicated that most of elderly people were suffering from psychosocial problems in moderate levels. The majority of the sample of elderly were in the age group (75 - 84) years and most of the elderly who spent in geriatric homes (1 - 4) years, males, divorced and uneducated. Results of the study showed the existence of a high significant relationship among the elderly who were uneducated and divorced which suffered from psychosocial problems.The study concluded that the psychosocial problems for elderly were in the age group (75 - 84) years and in moderate levels.The study recommended to improve care for elderly people and provide psycho educational programs for them to increase their knowledge toward the psychological problems and provide psychological support to improve their psychological status
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الاهمية الكيميائية الحياتية لنبتة العليق الاحمر كماسك طبيعي في حالة زيادة الحديد Biochemical Importance Of Rubus Idaeus As A Natural Chelator In Iron Overload Status

اسم المؤلف: حازم علي حسين
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اسم المشرف: مفيد جليل عوض مؤيد عمران الغزالي
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: لمنع تراكم الحديد في الجسم، وخاصة لمرضى داء ترسب الاصبغة الدموية،او الذين يحتاجون الى نقل دم بصورة مستمرة، لابد من عمل مركب معه يعمل على استخراجه.نبتة العليق الاحمر تحتوي على كمية عالية من حامض التانيك وهو مركب متعدد الفينولات للنبات يعمل على مسك او حجز | To prevent iron overload, especially for those patient with hemochromatosis or those having chronic blood transfusion, iron must be chelated and excreted, Rubus Idaeus containing high quantity of tannic acid which is a plant polyphenol, chelate iron and excreted from the body. The present study aimed to evaluate the activity and efficiency of tannic acid in Rubus Idaeus fruit to reduce or eliminate iron overload through enhance direct impact on some of the body,s vital biological activities by using fresh crude plant as herbal medicine. This study is Cohort study designed. It is monitoring, detection, and investigation study that included some of groups that completely under control(control), and other group which induced iron overload , the iron overload group is subdivided to 5 groups, one of this sub gorups is treated with desferal(Deferroxamine),and the rest 3groups giving 3 different doses of pure fruit of Rubus Idaeus, while the least group is not treated with fruit or with desferalThe study included (60) Albino male mice divided into six groups with count (10) mice for each. First group was labeled as control (A). The other five groups received intra peritoneal injections of iron - dextran at a dose of 100 mg/kg/day B.w. (one dose every two days for 3 weeks) are the iron overload groups ,which are classified as a following : B1 group ,in which the iron overload induced mice treated with 100 mg/kg/day of Rubus Idaeus fruit, B2 group, in which the iron overload induced mice treated with 200 mg/kg/day of Rubus Idaeus fruit,B3 group ,in which the iron overload induced mice treated with 300 mg/kg/day of Rubus Idaeus fruit, group(C),in which the iron overload induced mice received 493mg/kg/day desferal by subcutaneous injection for 21 days beginning on the day following the first iron dextran injection, group (D) ,in which the iron overload induced mice neither received desferal nor Rubus Idaeus fruit. The experimental work was carried out in the animal house and in the Clinical Biochemistry Department / College of Medicine / Babylon University during the period from (October 2015 to August 2016). High - Performance Liquid Chromatography (HPLC) technique has been used for measurement of tannic acid in fruit in mice's serum. Enzyme Linked Immunosorbent Assay (ELISA) has been used for the measurement of serum ferritin, UV - Vis Spectrophotometer has been used for determination of GSH - Px and GST concentrations, while Graphite Furnace Atomic Absorption Spectrophotometer technique (GFAAS) has been used for concentration measurement of trace elements. There were hematological study have been carried out using special required equipment, protein analysis by electrophoresis has been used for mice's serum to detect protein changes for all groups. Results showed that Rubus Idaeus fruit contain good acceptable concentration of tannic acid up to (853 µg/gm),amount of trace element in the fruit plant was 14.12 ppm for Zinc,33.62 ppm for Iron,3.5ppm for copper(Cu),311.06 ppb for selenium(Se),40.13 ppb for chromium(Cr). Results also showed highly significant increase of Serum ferritin, hemoglobin levels, GST activity, Iron and Copper concentration, and decreased in chromium in iron overload group (D) (P<0.001) when compared with control group (A), while there were highly significant decrease of these parameters and increased chromium in group (B2) and group (C) as compared with control groups. Results also showed highly significant decrease of GSH - Px activity, Zinc and Selenium concentration, and increased in hemoglobin levels in group (D) (P<0.001) when compared with the control group, while there were highly significant increase of these parameters and decreased in hemoglobin level in group (B2) and (C)as compared with control and (A) groups. The study have been found positive effect of Rubus Idaeus on abnormal parameters and support the biological system which was clear in group (B2) and (C) which demonstrated that there were significant inhibitions to decrease or increase of these parameters than those in normal. The present study found that fruit of Rubus Idaeus in dose(200 mg/kg/day)in mouse(16.2mg/kg/day in human) gives more reasonable results than other 2 doses (100mg/kg,300mg/kg) in treatment of iron overload ,100mg/kg had no effect in reducing iron overload,300mg/kg chelate iron so more that causing anemia, while this study found a negative correlation between Ferritin and GSH - Px activity, serum chromium and Selenium concentration. Results also showed that there is a changes in protein bands in samples, new bands occurs in samples of induced iron overload group (D) due to increased production of iron regulating proteins. While these bands are absent in groups (A),(B2)
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تقييم مضاعفات ما بعد العملية للمرضى الخاضعين لجراحة العظام في مستشفى الحلة التعليمي Assessment Of Postoperative Complications For Patients Undergoing Orthopedics Surgery At Al - Hilla Teaching Hospital

اسم المؤلف: احمد رامز هلال
الجامعة: جامعة بابل - كلية التمريض
اسم المشرف: فخرية جبر محيبس الزبيدي
الموضوع العام: الطب
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: الخلفية : مضاعفات ما بعد العملية تتعلق بنقص في العناية ما بعد العملية تقود الى عدة مضاعفات ربما تتطور في عدة مرضى نتيجة تاثير التخدير العام ومخاطر اخرى مثل طول فترة الرقود في المستشفى، عدم الحركة بعد العملية، التدخين, 000 الخ. كل عوامل الخطورة ربما تؤدي ال | Background : Postoperative complication is a source of concern as insufficient postoperative care leads to many complications which may develop in many patients due to the effect of general anesthesia and other risk factors such as prolonged hospitalization, immobilization after surgery, smoking, …etc. All risk factors may lead to postoperative complications, thus they impose additional economic burdens on the society and the patient.Objectives : The purpose of this study was to assess the postoperative complications in patients undergoing orthopedic surgery and to find out relationship between socio - demographic characteristics, medical information and postoperative complications such as (age, gender, smoking, medication, …etc.). Methodology : The study was carried out from 25 January 2016 to the 30 November 2016, the sample was Non probability sample which consists of (100) adults patients (male and female) who were undergoing orthopedic surgery with lower and upper extremities' under general anesthesia, without chronic disease and age of patients 18 years older at Al - Hilla Teaching Hospital.To achieve the objectives of the study, the researcher established the questionnaire format which was composed of three - part, part one : socio - demographic characteristic (5) items, while part two : consisted of medical information of patients which comprised of (7) items and part three : consisted of (34) items of postoperative complications may happen postoperatively.Results : The results of this study indicated that a high percent of postoperative complications occurred in ages between (18 - 27)years. The study also revealed the highest percentage (38%) of patients were smokers who had high complications. In addition the current study founded that smoking appears to decrease postoperative vomiting rate in smoker (16.2 %) less than non - smoker (36.7 %). The rate of vomiting in female (60%) is more than male (22.3 %). in addition the rate of infection in Smoker (11.6 %) more than non - smoker (1.7%). Total score of complications indicated the significant relationship between socio - demographic characteristics, medical information and postoperative complications like (age, smoking, occupation, education level, and medications used) as it is proved by chi - square tests. Recommendations : According to the current study, the researcher recommends to Increase knowledge of nursing staff regarding postoperative complications by continuing education , so the nurses can identify and prevent postoperative complication.Increase knowledge of patients regarding postoperative complications through provide them by advices or list in which is containing information or pictures that occur in patients with orthopedics surgery such as deep vein thrombosis, wound infection, and how to prevent them.
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تقييم الحالة التغذوية للاطفال دون سن الخامسة من العمر في مدينة الحلة Assessment Of Nutritional Status Among Children Less Than 5 Years Old In Al - Hilla City

اسم المؤلف: اسماعيل حسن جواد الموسوي
الجامعة: جامعة بابل - كلية التمريض
اسم المشرف: قحطان هادي حسين الجبوري حسن علوان بيعي
الموضوع العام: الطب
الموضوع الدقيق: التمريض
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: اجريت دراسة مقطعية وصفية خلال الفترة من 1 تشرين الاول 2015 الى 27 اب 2016 لاجل تقييم الحالة التغذوية للاطفال دون الخامسة من العمر في مدينة الحله من خلال قياس (الوزن للطول والعمر) من خلال المقاييس الجسمانية, وكذلك لايجاد العلاقة ما بين الخصائص الديموغرافية
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دراسة انزيم التيلومريز وجين الكلوتاثيون بيروكسيديز الاول في مرضى السكري النوع الاول Telomerase Enzyme And Glutathione Peroxidase1 Gene In Type 1 Diabetes Mellitus Patients

اسم المؤلف: دعاء مهدي هادي الحكاك
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اسم المشرف: مها فاضل سميسم علي حسين البياتي
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: Type 1 diabetes is characterized by an immune - mediated depletion of ? - cells that results in lifelong dependence on exogenous insulin. Accumulating evidence suggests that oxidative cell injury caused by free radicals contributes to the development of type 1 diabetes mellitus (T1DM) complications and decreased efficiency of antioxidant defenses (both enzymatic and nonenzymatic) seems to correlate with the severity of pathological tissue changes in T1DM, So many studies have tended to analyze the genetic material that can be related to the occurrence of the disease. Different combinations of genetic defects of antioxidant enzyme are expected. This could readily provide an explanation of the heterogeneity of T1DM.The aim of this study is to assess the differences of GPX1 genotype in T1DM as compare with controls. And the effect of C/T at nucleotide 1050450codon 198 of GPX1 gene polymorphisms on serum glutathione peroxidase (GPX) and telomerase enzyme (TE) concentration in T1DM patients and controls. This study included (108) persons, their ages between (28 - 42 years) and body mass index in normal and overweight (68) of them were uncontrolled diabetes type 1 (HbA1c ? 6.5 %), (34) of them were male patients (M group), the other (34) were female patients (F group), and the other (40) apparently healthy as control group (20) male (MC group) with (20) female (FC group). The sera sample of all groups were used to measure the concentration of fasting blood glucose by using colorimetric methods and ELISA method for determination (TE), total antioxidant capacity (TAO - C), glutathione (GSH), and glutathione peroxidase1 enzyme, while whole blood samples from study subjects were used to measure HbA1c and extract DNA for the study of polymorphisms in GPx1 gene.The results of the present study showed1 - A significant increase in glucose, HbA1c in both male and female patients compared with controls group. (P < 0.0001) and (p< 0.05) respectively.2 - The study showed significant decrease (p? 0.001) in telomerase enzyme in both M and F as compare with MC and FC groups,3 - There was no significant association between M and F (P=0.106) and between MC and FC (P=0.327) regarding to gender.4 - The result showed that telomerase concentration significantly decrease with age (p - value<0.001) which indicated by negative correlation between telomerase concentration and age.5 - The result showed significant negative correlation between telomerase enzyme concentration and BMI in patients and controls.6 - The result showed significant decrease in TAO - C in patient as compared with control groups (P=<0.001)7 - GPX1 concentration significantly decreased in patient as compared with control groups (p - value <0.001 )8 - Significant increase in Glutathione concentration in patients as compared with controls (p - value <0.05)9 - Data on the genetic patterns were analyzed using polymerase chain reaction technique - RFLP revealed, were defined as : the codon 198 of Gpx1 genotyping have the homozygous wild - type (CC) Pro/Pro, the homozygous mutant (TT) Leu/Leu, and heterozygous (CT) Pro/Leu allele. There was significant difference between genotype distribution and frequency of alleles between the two groups of patients (M and F) versus (MC and FC) (odds ratio = 33, into confidence level of 95% : 1.65 to 656.26) and P value ( 0.0219) for M vs. MC, and (OR = 12.60, into the proportion of 95% confidence level : 1.93 to 82.08) and P value (0.0081) for F vs. FC. Also, the frequency of TT genotypes in GPX1gene in male and female were47% and 61.7% compare to control male(0%) and female(10%).10 - The allele frequency showed significant differences in all sample (p=0.0013), in male (0.14) and in female (0.0020).11 - There was significant difference in telomerase concentration (p= 0.001) and in glutathione peroxidase concentration (p< 0.0005) in patients group depending on different of the GPX1 genotyping.12 - Depending on GPX1 genotype there were significant differences in BMI in normal weight and in overweight between patient and control (p=0.0375) and (p<0.0018), respectively.In Conclusion, the TT genotype of The GPX1gene variants Pro 198 Leu may be risk factor to T1DM patients. TIDM significantly associated with glutathione peroxidase and telomerase level in patients with TT genotypes of GPX1 gene compared to those with CT and CC genotypes, and this may be considered as a risk factor for senescence and mortality in T1DM. patients, also there is significant negative correlation between telomerase enzyme and BMI in patients and controls.
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التغيرات الحاصلة في نسب الانسولين والاحماض الصفراء والكوليسترول 7 الفا هيدروكسليز وفوق الاكسيد الفائق في مصل مرضى حصى المراره Serum Insulin, Bile Acid, Cholesterol 7 - Alpha Hydroxylase And Superoxide Dismutase Changes In Patients With Gallstone

اسم المؤلف: سماح سجاد كاظم الشمري
الجامعة: جامعة بابل - كلية الطب - قسم الفسلجة والفيزياء الطبية
اسم المشرف: محمد عبيد المحمدي علي خير الله الشاعلي
الموضوع العام: الطب
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2017
مكان الجامعة: بابل
المستخلص: يعتبر مرض حصى المرارةمن اكثر امراض الجهاز الهضمي شيوعا، ووتشكل عبئا كبيرا على انظمة الرعاية الصحية. معظم الناس (حوالي 80 ?) مع حصى المرارة ليس لديهم اعراض. وتشمل مضاعفات حصى المرارة التهاب المرارة والبنكرياس.الهدف من الدراسة : 1 - للتحقيق في العلاقة بين | A gallstone is a stone formed within the gallbladder out of bile components. Cholelithiasis or Gallstone disease (GD) is one of the most prevalent gastrointestinal diseases, with a substantial burden to health care systems. Most people (about 80%) with gallstones are asymptomatic. Complications of gallstones include inflammation of the gallbladder, pancreas. Objective 1. To investigate the association between serum level bile acid and cholesterol 7 - alpha hydroxylase and the development of gallstone disease. 2. To Evaluate the change serum level insulin changes and its effect on gallstone formation. 3. The determination of serum superoxide dismutase changes in patients with gallstone. Material and Methods In this study, one hundred sixty (160) patients with gallstone aged (20 - 70) years and one hundred sixty (160) age and sex match subject (control group) had involved in this study. The patients were intended to undergo surgical removal of gallbladder in Al - Hilla general teaching hospital during the period from November (2015) to May (2016). Blood samples were obtained from all patients prior to surgical treatment. Serum was obtained by usual methods and analyzed for insulin, insulin resistance Cholesterol 7 - alpha hydroxylase, Superoxide Dismutase, Bile acid (Deoxycholic acid and Chenodeoxycholic acid) and lipid profile {total cholesterol, triglyceride, high density lipoprotein - cholesterol and low density lipoprotein cholesterol}. And qualitative analysis of gallstone (Cholesterol stone, mixed stone, pigment stone), then these parameters compared with those of control groups. In addition, a demographic comparison regarding to the age, sex and body mass index between the patients and control groups was carried. Results The results of this study show higher significant percentage of gall stone in female (81%) than male (19%) in the patient group. There was an insignificant difference between male and female patients, according to age group (P<0.05). There is a higher significant (p>0.05) family history in the patients with gallstone compared with control subjects. Additionally, There is highly significant percent of female using oral contraception in pateints than control group (p > 0.01). Similarly, smoking, parity,Type 2 diabetes mellitus and Body Mass Index are found to be significantly higher inpatient group (p>0.01). This study demonstrate that insulin and insulin resistance are significant higher in sera of patients with gallstone as compared with the control group. (p>0.01) Regarding the cholesterol 7 - alpha hydroxylase, superoxide dismutase and Bile acids are found to be significantlylower in sera of patients with gallstone as compared with the control group, p< 0.01). It has also found that there are a higher significant difference in gallstone patients than control regarding total cholesterol, triglyceride, high density lipoprotein - cholesterol and low density lipoprotein cholesterol levels were significantly higher than that of control group (p>0.01). Meanwhile, all these parameters in the study are variated according to gender. However The qualitative analysis of stone that show cholesterol stone is more common than other types.Conclusions In this study the most studied parameters including of Insulin and insulin resistance, cholesterol 7 - alpha hydroxylase, superoxide dismutase and Bile acids, cholesterol, triglyceride, high density lipoprotein - cholesterol and low density lipoprotein cholesterol are significantly different in gallstone patients compared to control subjects and such differences are demographically affected depending on the age, sex, BMI, parity, contraceptive and smoking.
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Effect Of SNP rs198389 of BNP Gene On The Natriuretic Peptides Levels In Cardiovascular Patients

اسم المؤلف: Alaa Salman Idan Al - Ibrahimi
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اسم المشرف: Monem M. Al shok Moaed E. Al Gazally
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بابل
المستخلص: Acute coronary syndrome (ACS) refers to any group of acute signs and symptoms attributed to sever obstruction of the coronary arteries. Acute coronary syndrome usually occurs because of one of three problems : ST elevation myocardial infarction, non - ST elevation myocardial infarction, and unstable angina. These types are named according to the results of the electrocardiogram (ECG). In addition to clinical and electrocardiogram (ECG) findings, several biochemical markers are considered in patients with chest pain to diagnose myocardial ischemia. Heart failure (HF) according to American College of Cardiology (ACC) and American Heart Association (AHA) is a complex clinical syndrome that can be caused by any structural or functional disorder in the heart that fails the capability of the ventricle to fill with or to eject blood. The diagnosis is often performed clinically on the basis of the presence of dyspnea, fatigue, signs of fluid overload, such as pulmonary crepitation, peripheral edema, and distension of jugular vein.B - type natriuretic peptide (BNP) and N - terminal pro - BNP (NT - proBNP) are secreted by human atrial and ventricular myocardium. The rise in BNP and NT - proBNP levels after ACS and HF correlates with infarct size and regional wall motion abnormalities. Echocardiography remains the most frequently used and usually the initial imaging test to evaluate all cardiovascular diseases related to a structural, functional, or hemodynamic abnormality of the heart or great vessels. This study is designed to investigate and assess the serum concentrations of BNP and NT - proBNP in patients with HF and ACS; In addition, almost equal number of males and females are chosen to control the effect of age and gender on the levels of BNP and NT - proBNP. Also, the study aims to evaluate the effect of BNP gene T - 381C (rs198389) polymorphism on the plasma human levels of BNP and NT - proBNP and compare the results that will obtain with healthy control.The present study was involved (70) patients, (35) of them with ACS and the other (35) with HF. The study also includes (22) subjects were taken as control group. The sera obtained from the blood of patients and control subjects were used to measure the concentrations of BNP and NT - proBNP, while whole blood samples from study subjects are used to extract DNA for the study of polymorphism in BNP gene.The results indicate both the ACS and HF groups have significantly higher levels of BNP and NT - proBNP when compared to control group, also HF patients have higher levels of both parameters than ACS patients, in all comparison (p
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المستويات والانماط الجينية المتعددة للانترلوكين - 6 في مرضى التهاب المفاصل الرثوي في محافظة بابل/العراق Interleukin - 6 Gene Polymorphisms And Levels In Rheumatoid Arthritis Patients In Babylon Province / Iraq

اسم المؤلف: سارة حسين عيدان
الجامعة: جامعة بابل - كلية الطب - قسم الكيمياء الحياتية
اسم المشرف: عبد السميع حسن الطائي صباح جاسم الربيعي
الموضوع العام: الطب
الموضوع الدقيق: الكيمياء الحياتية السريرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2011
مكان الجامعة: بابل
المستخلص: التهاب المفاصل الرثوي هو احد الامراض المناعية الذاتية الالتهابية المزمنة الذي يتميز بالتهاب المفاصل المتماثل المستمر الذي يصيب عادة مفاصل اليدين والقدمين.تهدف هذه الدراسة الى التقصي عن العلاقة المحتملة بين مستويات الانترلوكين - 6 والانماط الجينية المتعددة | Rheumatoid arthritis (RA) is a chronic systemic inflammatory, autoimmune disease characterized by persistent symmetric polyarthritis that commonly affects joints of hands and feet.This study aims to investigate the possible association between interleukin - 6 (IL - 6) levels and ( - 174 G/C) IL - 6 promoter polymorphism in RA in Babylon Province. 60 RA patients and 60 healthy controls matched in age and sex were included in this case control study. Measurement of serum IL - 6 and serum anti cyclic citrullinated peptide (ACCP) antibodies were assayed using commercially available ELISA kit. Measurement of blood rheumatoid factor (RF) was assayed by use slide agglutination test for the qualitative and semiquantitative. Whereas, blood C - reactive protein (CRP) was determined using latex - enhanced nephelometry. Disease severity score of RA patients was determined by use DAS - 28. DNA was isolated from white blood cells (WBCs) and ( - 174 G/C) IL - 6 gene promoter polymorphism was determined by polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) technique. the study was found significantly high levels of serum IL - 6 and ACCPA in untreated and in treated RA patients when compared to healthy controls. RF of patients with RA in the present study was found to be positive in 83.32% and negative in 16.67 % in overall RA patients, whereas was negative in 99% of healthy control. CRF of patients with RA in the present study was found to be positive in 78.4% and negative in 21.6 % in overall patients with RA, and was positive in 20% of healthy control. Correlation between DAS - 28 and IL - 6 levels in untreated and in treated RA patients were significant positive correlation. Correlation between IL - 6 and ACCPA in untreated and in treated RA patients were significant positive correlation. Correlation between DAS - 28 and ACCPA in untreated and in treated RA patients were significant positive correlation. The Genotype of ( - 174 G/C) IL - 6 gene promoter polymorphism and its percentage in patient found to be 80% GG,18.3% GC and 1.6% CC, whereas in healthy control 98.3% GG, 1.6% GC and 0% CC. Relation between both of IL - 6 levels and DAS - 28 with genotyping of ( - 174 G/C) IL - 6 gene promoter polymorphism in untreated and treated RA patients were found to be positive significant relation. The high levels of IL - 6, and its positive relation with DAS - 28 may suggest a possible role of IL - 6 in the pathogenesis of RA. Moreover, these biomarkers can be used as markers of disease activity in the diagnosis and treatment of RA. ( - 174G/C) IL - 6 polymorphisms are also associated with the RA risk, and the C allele of IL - 6 promoter polymorphisms has dramatically increased the susceptibility of RA in Babylon population. This finding suggests that the ( - 174 G/C) IL - 6 gene promoter polymorphism may also be used as another genetic marker for the onset and development of RA in Babylon population.
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مستخلصات الشاي تاثيرها الذاتي او الاضافي على حياة خلايا السرطان : دراسة داخل وخارج الانبوب Herbal Tea : Its Own Or Additive Effect On The Survival Of Cancer Cell Line : An In Vitro And Ex Vivo Study

اسم المؤلف: هدى غسان حميد
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اسم المشرف: مروان صالح النمر ناهي يوسف ياسين
الموضوع العام: الطب
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2014
مكان الجامعة: بغداد
المستخلص: اجريت هذه الدراسة في فرع الفارماكولوجي في كلية الطب في الجامعة المستنصرية بالتعاون مع مركز ابحاث السرطان والوراثة\الجامعةالمستنصرية خلال الفترة من شهر كانون الثاني - شهراب لسنة 2014. الدراسة اقرت من قبل مجلس كلية الطب. صممت هذه الدراسة لتوضيح فعالية نبات ا | This study was conducted in the Department of Pharmacology at College of Medicine with incorporation of the Iraqi Center for Cancer and Medical Genetic Research at Al - Mustansiriya University, Baghdad, Iraq during 2014. This study was designed to elucidate the anti - cancer effect of Camellia sinensis by using four types of tea (black, green, white and oolong). Two experimental cancer models applied in this study; cancer cell lines (In vitro) and mice - bearing tumor (ex vivo). Several methodological and extracted aqueous and organic solvents were used to extract the tea. Microwave assisted extraction using distilled water as a solvent is applied in this study as the yield of bioactive substances are higher than other methods and organic solvents. The antioxidant activity was evaluated through the quantification of total flavonoids, total polyphenolic compound (bioflavanoids), total flavonols, reducing power, and proanthocyanidines. The scavenging property against reactive nitrogen species also was studied. The result showed that the different tea types contain approximately the same quantity of phenolic compounds; the only significant difference was in the proanthocyanidins level, which is a class of flavanols, found in high quantity in green tea compared with other tea extracts. Moreover, a significant scavenging property of peroxynitrite radical observed with all tea extracts. The extracts of black, green and oolong tea prevented or halted nitric oxide generation whereas the white extract tea promoted its generation, that is, a nitric oxide donor. The in vitro cytotoxic activity of Camellia sinensis in form of black, green, white and oolong tea was evaluated against four different types of cell lines. These are the AMN3 mammary cell carcinoma, Rhabdomyosarcoma, HeLa cells and Rat embryo fibroblast cells). The results showed greater effect of green and black tea over white tea and oolong tea against mammary cell carcinoma while the results of rhabdomyosarcoma cell line, which is an aggressive cancer cell, revealed a significant inhibitory effect of the growth of these cells by white and oolong tea extracts. All four types show almost equal percent of growth inhibition on HeLa cell line with the white tea been the most significant. A significant inhibitory effect of all tea extracts against the growth of rat embryo fibroblast cells indicated that the cytotoxic effect of the Camellia sinensis extended to normal cells and not specific to cancer cell. In addition, the antitumor effect of tea extracts was investigated (ex vivo) on BALB - c mice bearing - tumor. The volume, shape and color of the tumor masses were examined, in addition to measurement of the tissue malondialdehyde level as a biomarker of the lipid peroxidation, total tumor protein measurement and a histopathological study were done. The white tea showed antitumor effect by attenuating all the biomarkers of tumorogenesis. Herbal tea extracts induced DNA damage in term of separation the double strands molecule of calf thymus double stands DNA and human genomic DNA which may partly explained anti - cancer effect. We concluded that white tea extract is a promising nutrient that ameliorates the histopathological changes in mice bearing mammary tumor via generation reactive oxygen species by the evidence of activation lipid peroxidation process. Camellia sinensis plant can induce non harmful effect on DNA
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تاثير كل من عقار الروزوفاستاتين وعقار الاتورفاستاتين على مؤشرات نسب السكر المصاحبة للسمنة المحدثة في الفئران Effects Of Atorvastatin Versus Rosuvastatin On Glycaemic Indices In Diet Induced Obese Mice

اسم المؤلف: نورس لطيف وهاب
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اسم المشرف: علي اسماعيل عبد الله محمد حيدر مطير القريشي
الموضوع العام: الطب
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بغداد
المستخلص: Numerous interventional cardiovascular disease outcome studies have resulted in statins being an essential factor of cardiovascular primary and secondary prevention strategies.In recent years there was ahigh concern that statin use is associated with diabetes new onset which is strong, independent risk factor for cardiovascular (CV) and cerebrovascular outcomes ,several studies resulted in conflicting results regarding different statin types & dose effect on glycemic control. Atorvastatin which is the most widely used statin worldwide and rosuvastatin the most efficacious ;they have different structural characteristics that have been speculated to have influence on diabetes onset.Aim of the study : The present study aims at investigating the effect of different doses of atorvastatin and rosuvastatin on glycaemic indices and metabolic disorders on mice model of diet induced obesity. Materials and method : The animals were divided into two groups : one served as control that received normal regular chow & the other group received high fat diet for the whole 12 weeks of experiment.After eight weeks of HFD feeding ;group (2) farther subdivided into five groups(12 mice in each) ; the first group received HFD only ,the second group received single daily dose / po of 20mg /kg rosuvastatin ,the third group received single daily dose / po of 40mg /kg rosuvastatin ,the fourth group received single daily dose / po of 20mg /kg atorvastatin ,and the fifth group received single daily dose / po of 40mg /kg atorvastatin for the last four weeks of experiment.Body weight ,food intake, lipid profile ,glycaemic indices were taken at baseline ,before treatment and after treatment.At the end of experiment ,animals were sacrificed , plasma & tissue sample were collected for biochemical analysis and histological observations.Results : Results of the present study shows that high fat diet feeding resulted in obesity development and metabolic abnormality like; hyperglycemia ,hyperinsulinemia ,insulin resistance , dyslipidemia and moderate to severe hepatic steatohepetitis compared to control group. and treatment resulted in significant improvement in lipid profile ,reduction in food intake ,body weight ,also associated with improvement in insulin sensitivity , hepatic steatohepetitis and reduction in insulin secretion.twenty mg/kg dose of atorvastatin showed better influence on glycaemic indices and comparable influence on hepatic picture over fourty mg/kg does while twenty mg/kg dose of rosuvastatin resulted in deterioration of glycaemic indices and no apparent improvement in hepatic steatosis. Unlike group that received 40 mg /kg rosuvastatin which showed significant improvement in all related metabolic disorders. Conclusion : Feeding mice with high calories diet for 2 month result in induction of obesity and disturbance of metabolic parameters. Treatment with rosuvastatin or atorvastatin has good impact on bodyweight , metabolic derangements &hepatic steatosis in obese mice. Both drugs seems to improve lipid profile in dose dependent manner, however their effects on glycaemic indices has different attitude. It is seems that rosuvastatin, especially at high dose, has better impact on glycaemic indices than atorvastatin and this might attributed to the difference in their pharmacokinetic properties
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التقييم الفسلجي للاعتلال العصبي الذاتي لمرضى داء السكري

اسم المؤلف: نسرين قادر كامل
الجامعة: الجامعة المستنصرية
اسم المشرف: محمد شريف عبد الله موسى محمود مربط
الموضوع العام: الطب
الموضوع الدقيق: الفسلجة
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2004
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Autouomic neuropaty
  • diabetics mellitus
  • heart rate
  • blood pressure
  • E C G
  • cardiovascular reflex
المستخلص: (Diabetes Mellitus) D.M : - is the most common endocrine disease, characterized by abnormalities of glucose, protein and lipid metabolism. Diabetic neuropathy is one of the long term chronic complications, which contributes to increase the morbidity & mortality rate in diabetes. One of the earliest manifestations of diabetic autonomic neuropathy is denervation of the cardiovascular system, assessment of cardiovascular reflexes affords a satisfactory evaluation. Along duration time.A battery of bedside clinical tests was used to assess the autonomic function of the heart. This is the response of blood pressure to sustained handgrip and standing - up. The R - R interval change and Q - T interval change in the E, C G in response to standing - up, deep breathing and valsalva maneuver. Number of the patients was 40 diabetic subject and 22 age and sex matched healthy controls. Insulin dependent diabetes Mellitus (IDDM) was 25(62.50%) of cases, non insulin dependent Diabetes Mellitus (NIDDM) was 15(37.5%) of cases, autonomic neuropathy was detected in 23 patients (57.5%), Orthostatic hypertension in 19 cases (47.5 %), abnormal blood pressure response to sustained hand grip in 20 (50%), abnormal valsalva ratio in 10 (25%), abnormal heart rate response to deep breathing in 11 cases (27.2%).Among the 13 patients with cardiac diabetic autonomic neuropathy, had a Q - Tc interval of > 440 ms ( p < 0.05 ). Compared to the remaining 4 patients had normal Q - Tc interval of 399.5 ± 37.49ms.Cardiovascular tests for cardiac autonomic neuropathy showed increase prevalence with increase in the duration of Diabetes Mellitus above 15 years.This study showed that diabetics had significantly impaired cardio - autonomic reflexes compared to non diabetics. Also, other group of diabetics who have apparently normal cardio - autonomic reflexes were found to have significantly different values compared to the control group, (heart rate variations with deep breathing and valsalva maneuver had a negative correlation with age)
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تاثير استخدام عقار الميتفورمين منفردا او مع عقار السيتاكلبتين على مستويات الاومنتين - 1 لدى مرضى داء السكري من النوع الثاني Effects Of Metformin Alone Or In Combination With Sitagliptin On Serum Omentin - 1 Levels In Patients With Type - 2 Diabetes Mellitus

اسم المؤلف: ميقات طالب حمادة
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اسم المشرف: حيدر مطير خليل القريشي عبد الكريم يحيى السامرائي
الموضوع العام: الطب
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بغداد
المستخلص: الخلفية : داء السكري يشير الى مجموعة من امراض الايض مع ارتفاع مستوى سكر الدم. يمثل النوع الثاني من داء السكري ما نسبته 90 - 95% من جميع حالات السكري. يمثل النقص في الانسولين ومقاومة الانسولين وغيرها من الاضطرابات الهرمونية المشاكل الاساسية لمرضى السكري من ال | Background : Diabetes mellitus (DM) describes chronic metabolic disorders with hyperglycemia. Type II DM (T2DM) represents for approximately 90 - 95% of all diabetic types. A combination of insulin deficiency, insulin resistance and other hormonal irregularities are key problems with T2DM. Adipose tissue can be classified into two types : the brown and white adipose tissues. The white type is considered an important secretory organ which produces many bioactive molecules, collectively termed adipokines. Recently, a new adipokine named omentin - 1, has been identified and it was found that individuals with impairment in glucose homeostasis and newly diagnosed T2DM showed a lower serum omentin - 1 level. However, the effects of antidiabetes drugs on serum omentin - 1 level had not been studied extensively.Objective : The current study was design to measure serum omentin - 1 in T2DM as comparing with control subjects, also to study the effect of three months therapy with metformin and/or sitagliptin (when added to ongoing metformin therapy) on serum omentin - 1 levels in addition to other parameters.Method : This study was carried out on thirty healthy control subjects, and sixty three T2DM patients. The patients enrolled in the current study were divided into two groups. First group : included thirty one of newly diagnosed T2DM patients, started treatment with metformin. Second group : included thirty two patients with T2DM, already on ongoing metformin therapy and started treatment with sitagliptin. All patients received their treatment for three months duration, and blood samples were collected from them at the beginning of the study and after three months of starting treatment to measure the possible change in the studied parameters which include : fasting blood glucose (FBG), postprandial blood glucose (PBG), Glycosylated haemoglobin (HbA1c), serum level of insulin, insulin resistance (IR), serum omentin - 1 levels, lipid profile, body mass index (BMI) as well as blood pressure. Results : The results showed that baseline level of serum omentin - 1 in the newly diagnosed T2DM was significantly lower than matched control subjects. The level of omentin - 1 was significantly reduced after three months duration of treatment in sitagliptin group with no significant change in metformin group. FBG, HbA1c and PBG were decreased significantly after three months in metformin group, while in sitagliptin group, only HbA1c and PBG were decreased significantly after three months. In both groups, and after three months duration of treatment, there were no significant changes in serum level of insulin, IR, TG, VLDL - C, HDL - C, BMI, and blood pressure.Conclusion : In newly diagnosed patients with T2DM, serum omentin - 1 was reduced compared to age and BMI matched healthy subjects. Three months treatment with sitagliptin resulted in a significant reduction in omentin - 1 levels compared with baseline values. However, three months treatment with metformin had no significant effect on serum omentin - 1 level compared with pre - treatment value
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تاثير استخدام عقار الكلورال هيدريت منفردا او استعماله مجتمعا مع عقار الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال Chloral Hydrate Alone Or In Combination With Diazepam As A Sedative For Auditory Brainstem Response Testing In A Pediatric

اسم المؤلف: مريم محمد حميد مصطفى
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اسم المشرف: حيدر مطير خليل القريشي حيدر وهاب السرحان
الموضوع العام: الطب
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بغداد
المستخلص: اجريت الدراسة الحالية لبحث تاثير استخدام الكلورال هيدريت منفردا او استعماله مع الديازيبام كمهدئ عند قياس الاداء السمعي الدماغي عند الاطفال من اجل تقييم ما اذا كان اضافة الديازيبام له تاثير ايجابي او سلبي.اعتمدت الدراسة الحاليه على160 متطوعا من الاطفال ال | Background : children usually need sedation for diagnostic and therapeutic interventions. It is well known that pediatrics age groups are at higher risk for sedation - related complications than adults. Auditory brainstem response testing is one of the important diagnostic procedure that usually need sedation in order to preformed in children. Chloral hydrate is a hypnotic agent used since 1832 with low incidence of adverse events; whoever, despite the world wide use it is being abandoned due to bitter test, long time of sedation onset, vomiting and mild sedation. Rectally diazepam, on the other hand, produces higher and fast concentration in CSF with greater rate of success but probably with higher adverse events. Aim of the study : were to compare the sedative effect of chloral hydrate with chloral hydrate diazepam combination as well as their related adverse effects in children underwentg auditory brainstem response testing. Methods : in this randomized clinical study, 160 child underwent sedation for auditory brainstem response test participated. They were divided equally and randomly into 4 groups. Group A : Received 20 mg/Kg oral chloral hydrate as sedative, Group B : Received 20 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally, Group C : Received 40 mg/Kg oral chloral hydrate as sedative, and Group D : Received 40 mg/Kg oral chloral hydrate plus 0.5 mg/Kg diazepam rectally. At the beginning, blood pressure, respiratory rates, peripheral oxygen saturation recorded, and then re - recorded immediately after drug administration and at (3, 5, 10, 20, …. min). Ramsay sedation scale used for assessment of the sedation level which measured every 10 min. Results : This study shown the beneficial use of chloral hydrate in combination with diazepam as sedation in ABR test (in groups D) by increased in the sedated number (p<0.05), decreased in the requirement of chloral hydrate re - dose, increased in the number of children whom completed ABR test (p<0.05) without significant differences on side effects or vital signs compared with the others three groups. 4.3. Conclusion : From this study we concluded that : • Used of oral chloral hydrate in dose (20mg/kg) alone not sufficient as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (20mg/kg) in combination with rectal diazepam (0.5 mg/kg) better than used it alone as sedative in paediatrics for ABR test.• Used of oral chloral hydrate dose (40mg/kg) in combination with rectal diazepam (0.5 mg/kg) was the best sedative in paediatrics for ABR test. • Used of Chloral hydrate diazepam combination in ABR test of paediatrics increased the number of the sedated children, decreased the requirement of chloral hydrate re - dose, and increased the number of completed ABR test, with less complication
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تاثيرات استخدام عقار الفيراباميل وعقار السايكلوسبورين في حالة اعتلال عضلة القلب الناتج من استخدام عقار الدوكسوروبسين : في الفئران المختبرية Effects Of Verapamil,Labetalol And Cyclosporine Use In The Condition Of Cardiotoxicity Resulted From Doxorubicin Use : Animal Model Study

اسم المؤلف: محـمد عبد العزيز محـمد
الجامعة: الجامعة المستنصرية - كلية الطب - قسم الفارماكولوجي
اسم المشرف: حيدر مطير خليل القريشي خالد جمعة خليل
الموضوع العام: الطب
الموضوع الدقيق: الادوية والسموم
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2014
مكان الجامعة: بغداد
المستخلص: Doxorubicin is a member of anthracycline antibiotic that widely used in the treatment of different types of cancer such as hematological malignances, solid tumors, and different organ tumors, doxorubicin is very efficient in the treatment of cancer. But the use of doxorubicin is limited by the side effect of doxorubicin on the same organ, the most important organ that affected by doxorubicin is the heart, the toxicity of doxorubicin in the heart, the use of doxorubicin due to the cardiotoxicity that induced by doxorubicin will lead to cardiomyopathy and in the final result of these cardiotoxicity lead to congestive heart failure that occurred secondary to the cardiotoxicity may appear after long period of termination of treatment by doxorubicin.ObjectivesThe aim of the present study its investigate the possible modulation effect of drugs (verapamil, cyclosporine, labetalol) on the cardiotoxicity that induced by doxorubicin drug. Animals and methods forty Dwale - Spargue male rats where enrolled in this study, the animals divided into groups, (5) rats in each group and assigned as I,II,III,IV,V,VI,VII,VIII.Group I : received physiological saline (5ml/kg), orally, daily for ten days and served as the control.Group II : received a single dose of doxorubicin (15mg/kg), intraperitoneal and was sacrificed after 48 hours which served as doxorubicin group.Group III : received verapamil (5mg/kg), orally daily for ten days and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg), intraperitoneal were given.Group IV : received cyclosporine (0.5mg/kg), orally daily for ten days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg, intraperitoneal) was given.Group V : received cyclosporine (1mg/kg), orally daily for ten days ,and on day eight ,one hour after drug administration a single dose of doxorubicin (15mg/kg),intraperitoneal was given. Group VI : received both of verapamil (5mg/kg,orally) and cyclosporine (0.5mg/kg,orally) one hour apart, daily for ten days ,and on day eight, one hour after drug administration ,a single dose of doxorubicin (15mg/kg), intraperitoneal was given.Group VII : received labetalol (0.5mg/kg), orally daily for ten days, and on day eight, one hour after drug administration, a single dose of doxorubicin (15mg/kg, intraperitoneal) was given. Group VIII : received labetalol (1mg/kg, orally),daily for ten days ,and on day eight ,one hour after drug administration ,a single dose of doxorubicin (15mg/kg), intraperitoneal was given.Serum MDA, LDH, Troponin I, and interleukine - 17. Were measured and histopathological changes also viewed?ResultsThe results in this study showed an increase in the cardiac biomarkers in the doxorubicin group compared to the control group, the cardiac biomarkers that measured are LDH, MDA, Troponin I, interleukine - 17. Also the results showed histopathalogical changes in cardiac tissue in doxorubicin group as compared to the control group, also the results showed the pre - treatment with verapamil, cyclosporine low dose, cyclosporine high dose, combination of verapamil and cyclosporine low dose, labetalol low dose, labetalol high dose showed decreasing in the cardiac biomarkers MDA, LDH, Troponin I, interleukine - 17 to a significant amount compared to the doxorubicin group, also showed histopathlogical improvement in cardiac tissue. Conclusions Doxorubicin drug used as antineoplastic agent will produce a toxic effect on the cardiac tissue, this toxic effect will limit the use of doxorubicin, cyclosporine, labetalol and verapamil produced differential effects and protection from Doxorubicin induced cardio toxicity via amelioration of cardiac biomarkers and histopathological changes
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عزل وتحديد هوية فيروس الحصبة في علاقته ببعض الجوانب المناعية من الاشخاص النازحين الملقحين في محافظة بابل Isolation And Identification Of Measles Virus In Relation To Some Immunological Aspects From The Vaccinated Displaced Individuals In Babylon Governorate

اسم المؤلف: ليث احمد عمران كيف الكيف
الجامعة: الجامعة المستنصرية
اسم المشرف: محمد عبد كاظم حسن السعدي يونس عبد الرضا كحيوش الخفاجي
الموضوع العام: الطب
الموضوع الدقيق: الاحياء المجهرية
الدرجة: ماجستير
اللغة: الانكليزية
السنة: 2016
مكان الجامعة: بغداد
المستخلص: اجريت الدراسة لتقييم مناعة المجتمع لكلا النازحين والمقيمين الملقحين بلقاح فيروس الحصبة ضد خمج الحصبة في محافظة بابل. لذا تضمنت هذه الدراسة معايرة الحالة المناعية في امصال النازحين والمقيمين محافظة بابل مع عزل وتشخيص فيروس الحصبة من الحالات المشتبه بها. ت | The study was conducted to evaluate the herd immunity for both the displaced and residents vaccinated with measles virus vaccine against measles infection in Babylon governorate. Therefore this study includes the evaluation of the immune status in sera of Babylon governorate displaced and residents with specific aspect for isolation and identification of measles virus from suspected cases. The immune response was evaluated by means of ELISA test (enzyme linked immunosorbet assay) for titration of IgM and IgG immunoglobulin level, in addition to evaluation of perforin level in the sera of 90 measles vaccinated individuals included in this study (50 displaced and 40 residents) from different areas in Babylon governorate, that were collected during the period extent from January up to April of 2016. Data about individuals were fixed according to information of formula including age, sex, geographical location, place displace of displaced and the vaccination date. Successful virus isolation from suspected cases on two types of cells culture included Vero cells line and chicken embryo fibroblast was carried. The titer of the isolated virus on Vero cell line reached (105.8 TCID50 / 0.1ml),which was higher than the titer of the virus isolated on CEF which reach (105.4 TCID50 / 0.1ml) after the third passage of the virus. The isolated virus was confirmed by indirect immunofluorescence technique.The age of subjects included in this study ranged from <1 year up to 24 years old. The results revealed that 15 (30%) have positive IgM index in sera of displaced, whereas residents sera sample shown only 6 (15%) positivity. Howover, all 90 (100%) subjects of both groups showed positive IgG index. The results of the present study showed that there were no significant difference of perforin level in sera of refugees and residents at p<0.05.Assaying of immune response against measles virus by measuring IgM immunoglobulin in sera of vaccinated displaced and resident with measles vaccine reflected a highly significant difference between two groups which reached 0.43 mIU/ml in sera of displaced in comparison with residents sera which reached 0.34 mIU/ml. The result showed also high significant differences in IgM between females and males. The females sera IgM levels of displaced and residents were higher than its level in males sera which reached 0.47 mIU/ml and 0.35 mIU/ml, respectively, in comparison with male sera level which reached 0.40 mIU/ml and 0.32 mIU/ml, respectively. According to age group, the highest IgM value was recorded in displaced and residents sera in age group 10 - 14years (0.50 mIU/ml) and 5 - 9years (0.36 mIU/ml) respec - tively. Whereas the lowest IgM serum value was detected in age group <1 year (0.34 mIU/ml) and 15 - 19years (0.31 mIU/ml) for displaced and residents subjects. According to geographical location, the highest IgM level was detected in sera of displaced from Tal Afar city (0.44 mIU/ml) followed by displaced from Ramadi (0.41 mIU/ml) and the lowest IgM value was detected in sera of displaced from Mosul city (0.33 mIU/ml). Whereas the highest IgM value in sera of residents in the subjects of Al - Mahaweel city (0.37 mIU/ml) followed by subjects of Hilla and Al - Qasem city (0.29 mIU/ml and 0.28 mIU/ml) respectively. For IgG serum immunoglobulin the results revealed that there was no difference in significant levels in both group population. But according to age groups significant difference between displaced and residents was detected at p <0.05 in which the 1 - 4 years old showed the highest IgG serum level in both group (1.98 mIU/ml and 2.18 mIU/ml) respectively. While the lowest IgG sera value was recorded in displaced age group of < 1 year old (0.60 mIU/ml) compared with residents age group of 20 - 24 years old (1.65 mIU/ml).It could be concluded that the results showed that the displaced do not have any effect on the residents of the province of Babylon for measles as a result of the good immunization by Babil Health directorate following to the Ministry of Health.
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