دراسة مستوى بعض العوامل المؤكسدة والمضادة للتاكسد في مرضى اللوكيميا وسرطان الثدى == Profile study of some oxidant and antioxidant levels in leukemic and breast cancer patients
Author name:
نهاية مناحي العبودي
General topic:
Medicine
Specific topic:
Clinical Biochemistry
Degree:
Master
University:
University Of Basrah - Faculty Of Medicine
Language:
English
University location:
Basrah
First pages:
19T1737 - p.pdf
Abstract:
This study was carried out to evaluate the oxidant and antioxidant level in cancer patients in Basrah during the period from the first of October 2002 till the end of April of the 2003. A total of 98 patients were investigated, who were admitted to the Basrah General Hospital, Teaching Hospital and Basrah Hospital for Maternity and Pediatric in Basrah City. They were 52 female patients with breast cancer and 46 leukemic patients (24 male and 22 female). In addition 125 sex and age - matched persons without malignancy served as controls. They were 64 persons as control for leukemic patients (32 male and 32 female) and 61 females as control for breast cancer patients. The haematological parameters measured were haemoglobin concentration(Hb), packed cell volume (PCV) value and white blood cell (WBC) count, while the biochemical parameters measured were glutathione (GSH) level, uric acid, malondialdehyde (MDA) and phagocytic activity . The leukemic patients were subclassified into two groups according to their age (30 patients ≤16 years and 16 patients >16 years). The breast cancer patients were subclassified into three groups according to their age (11 females as 25 - 34 years old, 17 females as 35 - 44 years old and 24 females as ≥45 years old). The Hb concentration and PCV value were significantly decreased (P<0.05) in leukemic patients of age group 16 years old ,however, in age group > 16 years old ,the decrease were extremely significant (P<0.001). In breast cancer patients the Hb concentration decreased extremely significantly in all age groups (P<0.001). A highly significant decrease was found in PCV value of age group 35 - 44years old (P<0.01), whereas a significant decrease in 25 - 34 years and 45 years age groups (P<0.05) was observed. The WBC count in leukemic patients showed an increase in WBC count significantly in 16 years old age group (P<0.05) and extremely significant increase in >16 years old age group (P<0.001). In breast cancer the WBC count showed decrease in WBC count significantly in 25 - years old patients (P<0.05), highly significant decrease in 35 - years old patient (P<0.01) and extremely significant decrease in 45 years old patients (P<0.001). There were no significant differenses in Hb concentration, PCV value and WBC count between male and female leukemic patients. The biochemical investigation showed an extremely significant depletion in GSH levels in leukemic and breast cancer patients (P<0.001). The phagocytic activity was extremely significantly decreased in all leukemic patients (P<0.001) and highly significant increase in 25 - 34 years old breast cancer patients (P<0.01), significantly increase in 35 - 44 years old breast cancer patients (P<0.05) and extremely significant increase in 45 years old breast cancer patients (P<0.001). There was no significant difference between male and female leukemic patients in phagocytic activity. The MDA level was highly significantly increased in 16 years old leukemic patients (P<0.01) and extremely significant in >16 years old leukemic patients (P<0.001). In breast cancer the MDA level was highly significant increase in all age groups patients (P<0.01). The investigation of uric acid concentration shows extremely significant increase in all leukemic patients (P<0.001) and highly significance increase in 25 - 34 years old and 35 - 44 years old breast cancer patients (P<0.01). Also shows extremely significant increase in 45 years old breast cancer patients (P<0.001). In conclusion, cancer patients suffer a high degree of ROS formation causing considerable oxidative stress which associated with decrease glutathione level and significant degree of lipid peroxidation.
