عرض: 25 50 75 100 النتائج

نتائج البحث: 12 من أصل 12

The Effect Of The Addition Of Silanized Nano Titania Fillers On Some Physical And Mechanical Properties Of Heat Cured Acrylic Denture Base Material

اسم المؤلف: sama abdulrazzaq alwan
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
الجامعة: جامعة بغداد
مكان الجامعة: بغداد
الكلمات الدلالية:
  • mouth - surgery

Augmentation Of The Localized Bony Defects With Synthetic Bone Substitute In Simultaneous Dental Implant Surgery

اسم المؤلف: Mohammed Abd Alrazaq Hameed
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
الجامعة: جامعة بغداد
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Mouth - Surgery

The Effect Of Various Endodontic Irrigants On The Sealing Ability Of Biodentine And Other Root Perforation Repair Materials : In Vitro Study

اسم المؤلف: al - zubaidi ahmed kased
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
الجامعة: جامعة بغداد
مكان الجامعة: بغداد
الكلمات الدلالية:
  • mouth - surgery

انسلاخ المبيضات اللعابي المقاس بواسطة تفاعل البوليميراز المتسلسل الكمي اللحظي كاداة تنبؤ لحصول التهاب المبيضات الفموي عند مرضى الربو المتعاطين لدواء بيكلوميتازون المستنشق == Salivary Candidal Shed Measured By Real Time Quantitative Polymerase Chain Reaction As A Predictor of Oral Candidiasis In Asthmatic Patients On Inhaled Beclomethasone Dp Therapy

اسم المؤلف: نغم قطران رحيم
اسم المشرف: رعد محي الدين حلمي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الربو القصبي المزمن يمثل مشكله صحيه جديه في كل العالم وهو عادة يبدا في عمر الطفوله ويبقى المريض في كثير من الاحيان يتعاطى العلاجات المستنشقه مدى الحياة.انتشار الربو القصبي يزداد في كثير من دول العالم مما يجعله احد الامراض المعيقه والمهدده للحياة باعتبا | Asthma is a serious global health problem that usually starts in childhood and continues along patient’s life and most of them have to take inhaled therapy lifelong. The prevalence of asthma is rising in many countries of the world, making asthma one of the most disabling and life threatening diseases effecting patients with different age groups and social classes with variable clinical spectrums and outcomes starting from mild to severe disabling syndrome rendering nonproductive individuals to severe life threatening and sometimes fatal disease. Those patients continue inhaled steroid therapy for long duration, considered by GINA as first line treatment , however such a treatment is associated with local adverse effects on oral tissues, and one of the main concerns is the development of oral candidiasis, a chronic, potentially invasive, infection of oral tissues with fungus candida species resulting in failure of treatment. The scientific interests about such a serious complication have been raised over the past years and debates continued as the candida is considered one of the normal flora of the oral cavity in most of healthy population, however oral candidiasis in pathogenic forms still occur in immunocompromised patients including asthmatics on inhaled corticosteroid therapy.Aim of the study1. To investigate the effect of inhaled corticosteroid therapy in form of Beclomethasone Dipropionate250 microgram/dose CFC free in asthmatic patients on salivary candidal shed estimating by Real Time quantitative Polymerase Chain Reaction (RT qPCR) applied on direct unstimulated saliva samples.2. Evaluation of this shed as prediction of occurrence of oral candidiasis. Patients, Materials and MethodsThis study was conducted at Al Zahraa consultational Asthma and Allergy center - Baghdad Al Karkh Health Directorate from September 2013 to February 2014.The included patients were divided into 3 groups. Group A included asthmatic patients on inhaled Beclomethasone therapy, group B included asthmatic patients that never used any form of inhaled steroid therapy and group C was those asthmatic patients on inhaled Beclomethasone therapy who developed oral candidiasis. All patients were receiving two daily doses. The same exclusion forma was applied to choose Group D who were control healthy individuals. Each included patients and control cases were instructed to give saliva samples in the standard way and samples taken for estimation of candidal count by real time quantitative Polymerase Chain Reaction.Results During the study period, 698 patients were examined, however only 63 patients were included in the study. Those 63 were classified as follows : 28 patients were found on group, 28 were found on group B and only 7 patients were found on group C and 20 cases were selected in group D as a control.Group C patients were having the highest salivary candidal shed (mean=58.7x106 cn/ml) and longest duration of asthma (Mean=2718 days) and longest duration of Beclomethasone therapy (Mean=2224 days) and this was significantly higher than other groups (p<0.05).Group A patients were having the second highest rank after group C in regard of salivary candidal shed and both duration of asthma and Beclomethasone therapy. Inside each group, duration of asthma and duration of Beclomethasone therapy were associated with moderate positive correlation with salivary candidal shed (R>0.5).Age difference between groups were insignificant and age factor had no correlation with salivary candidal shed inside the groups.Discussion : Salivary candidal shed over the groups was directly related to the duration of inhaled Beclomethasone therapy and duration of asthma. They are significantly higher (p<0.01) as we go further from each group to the next, both appear as the reason behind increased candidal shed in groups A and C.The salivary candidal shed curve will gave us a very useful tool for follow up those patients on inhaled steroid therapy ,In addition , predict the risk of developing oral candidiasis and when to interfere prior to the establishment of Oral Candidiasis state as that we have noticed in the group C, in which it was recommended to stop inhaled steroid therapy and the patients would lose the benefits of the therapy.Conclusions1. Resting saliva samples with realtime quantitative PCR was a rapid and accurate tool in diagnosis of oral candidiasis.2. Salivary Candidal Shed could be used as a tool in predicting oral candidiasis in asthmatic patients on inhaled Beclomethasone therapy.3.Longer duration of asthma and longer duration of Beclomethasone therapy were associated with increased salivary candidal shed and established oral candidiasis have the highest amount of shed.4. Candida albicans are present in the oral cavity of any individual of our population

تقيم التسريب الجزني لمركبات الراتنج للحشوات الخلفية سونك فل مركب مستند على السيلورين ومركب نانوفل مستند على الميتاكرليت في : دراسة مقارنة == Microleakage Evaluation of Sonicfill

اسم المؤلف: مهند احمد الحداد
اسم المشرف: حكمت عبد الرحيم الغراوي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Resin composites have improved greatly since their introduction and are now the materials of choice for most of the restorations. This study was conducted with aim of comparing in vitro the marginal adaptation of three different, low shrink, direct posterior composites Sonic fill™ (nanohybrid composite), Filtek™ P90 (Silorane - based composite) and Filtek™ Z350 (nanofill composite) of a standardized Class V cavity after thermoal cycling. Sixty sound, freshly extracted human premolars were prepared with standardized Class V cavities. The specimens were divided into three groups of twenty teeth each according to the material used : Group A : The teeth were restored with Sonic fill™ posterior composite unidose capsules, Group B : The teeth were restored with a silorane - based posterior composite (FiltekTM P90), Group C : The teeth were restored with nanofill methacrylate - based composite (Filtek™ Z350 XT).After specimens were stored in distilled water at 37°C for 7 days, all specimens were subjected to thermocycling at (5° to 55 °C), then immersed in 2% methylene blue dye for 24 hours. For each group microleakage at the occlusal and gingival regions was estimated by determining dye penetration using scoring system under steromicroscope (10X). The statistical analysis of the results showed that, Filtek™ P90 silorane based composite exhibited the lowest mean of microleakage, with statistically highly significant difference (P < 0.01) when compared with Sonicfill™ composite and Filtek™ Z350 XT nanofill composite. On the other hand, the results of this study showed that Sonic fill™ composite exhibited no significant difference (P > 0.05) as compared with Filtek™ Z350 XT nanofill composite. Also, the results in this study showed that there is a highly significant difference (P < 0.01) in dye penetration between occlusal and gingival regions for each group

ضبط الحواف ومقاومة الكسر لاغلفة ال Ceramill Sintron المعدنية المصممة والمصنعة بالحاسوب مكسوة بثلاث انواع مختلفة من الخزف == Marginal Discrepancy And Fracture Resistance of CAD\CAM Ceramill Sintron Metal Copings With Different Porcelain Materials

اسم المؤلف: مصطفى نبيل عبد الغني
اسم المشرف: عمار عطا الله علي السعدي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: دقة الحواف والقوة، لاي ترميم معوض للاسنان هي صفة مهمة. ويمكن اعتبارعدم تطابق للحواف او قلة القوة سبب مهم يؤدي الى فشل التعويضات الاصطناعية للاسنان.لذلك تم اجراء هذا البحث لغرض تقييم اختلاف ظبط حافات ومقاومة الكسر لتيجان السيراميك المصنعة من اغلفة الC | Marginal fit and strength are important criteria for any restoration; poor marginal fit and low strength may be considered as a source of prosthesis failure. This study was performed to compare the marginal fit changes and facture resistance of metal ceramic crowns constructed from Ceramill Sintron metal coping veneered with three different porcelain veneering materials (Vita Master Koromikos VMK, Willi Geller Creation CC and GC initial MC). Also evaluating the influence of thermocycling on load at fracture value. The method included the use of master brass die which was milled to represent the prepared maxillary central incisor. Sixty metal copings were milled directly using Ceramill Sintron blank, then divided randomly into three groups. Each group consist of twenty metal copings, then veneered with porcelain : VITA for group A, Creation for group B and GC for group C. The marginal gap was measured before and after porcelain veneering for each group using travelling light microscope, then marginal fit changes was calculated. Fracture resistance test was done by Instron®, the master die was duplicated to sixty analogs then each analog was fixed into acrylic base. After that each crown was cemented onto the corresponding die analog using zinc phosphate cement. Ten samples of each group were subjected to compressive loading to fracture and other ten subjected to thermocycling followed by compressive loading to fracture.The result showed that GC group was highly significant different from other tested groups in marginal fit changes, whereas there was no significant different between VITA and Creation group. While there was significant difference among tested group at (P < 0.01) in fracture resistance, and the effect of thermocycling process did not significantly reduce the load at fracture for all groups.This study concluded that GC group present the least marginal fit changes, while the fracture resistance was highest for VITA group follow by Creation then GC. Thermocycling reduce load at fracture but not significantly.

تقييم صحة الفم والبروتينات اللعابية لدى المرضى المصابين بمرض باركنسن == Assessment of The Oral Health And Saliva Proteins In Patients With Parkinsons Disease

اسم المؤلف: صباح فرحان مشتت
اسم المشرف: هاجر ابراهيم عبد الله | مروان صالح النمر
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Background : Parkinson's disease (PD) is a progressive neurodegenerative disorder related to the loss or absence of dopaminergic neurons in the brain. The deficits caused by PD result in slowness of movement, tremor, rigidity, and dysfunction of behavior and these symptoms negatively influence the patient’s capability to carry out the daily oral hygiene manoeuvres.Aims of study : This study aims at using saliva as a biological fluid for assessment in detecting the biomarkers of Parkinson's disease and to assess the impact of this disease on the oral health of patients.Materials and methods : A total number of fourty participants were involved in the study; twenty subjects who appeared healthy (Group I) and twenty Parkinson's patients (Group II). Patients who are eligible for this study were cases of Parkinson's disease treated with anti - Parkinson's medications, both genders and their ages ranged from 40 - 75 years. Specific information related to the demographic characteristics and illness is obtained from each patient. The Brain Bank Diagnostic Criteria for Parkinson’s disease established by United Kingdom Parkinson's Disease Society was used. Each patient was subjected to oral examination during which DMF index was scored, oral health impact Profile OHIP - 14 was used and from each participant the whole unstimulated saliva was collected for biochemical analysis including total salivary protein, direct determination of saliva proteins and determination of ? - synuclein. Results : many oral and clinical signs and symptoms elsewhere in the body were reported in the patient with Parkinson's disease while the clinical features of Parkinson's disease observed in all patients despite of their treatment. Static tremor observed in 100%, rigidity in 70%, disturbances in the autonomic nervous system reflected on the cardiovascular, gastrointestinal and urinary tracts, orthostatic dizziness observed in 75%, dry mouth in 65% difficulties in swallowing in 40% and constipation in 70%. Teeth examination revealed that Parkinson's patients have a non - significant high means of decay and missing teeth compared with healthy subjects. The total saliva protein in Parkinson's patients is significantly higher than the corresponding value of healthy subjects. The extinction coefficient of uncontaminated protein in Parkinson's patients is significantly less than the corresponding values of healthy subjects and salivary ? - synuclein level is significantly less in Parkinson's patients than healthy subjects.Conclusions : Salivary ? - synuclein may serves as a biomarker for Parkinson's disease. Specific protein with extinction coefficient 27.5 M.Cm - 1 is secreted in saliva of Parkinson's patients. The characteristic saliva protein produced in patients with Parkinson's disease is deficient in tyrosine level and Dental care is required for both groups (Parkinson's patients and healthy subjects).

الاستريتين الفموي مقابل غلوكونات الزنك عن طريق الفم : دراسة علاجية مقارنة وعبورية في علاج مرض بهجت == Oral Acitretin Versus Oral Zinc Gluconate As A Comparative Cross - Over Therapeutic Study In Treatment of Behcet,S Disease

اسم المؤلف: سناء عبد الحميد حسين
اسم المشرف: هاجر ابراهيم عبد الله | عادل عبد الغفور النعيمي
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: اساس البحث : مرض بهجت هو اضطراب جهازي حيث ان اسبابه المرضيه ليست محدده جيده.المظاهر الاكثر شيوعا هي الاغشيه المخاطيه الجلديه ولكن يمكن ان يشمل العين, انظمة القلب,الاوعيه الدمويه والجهاز العصبي. هناك العديد من طرائق المعالجه الموضعيه والجهازيه. تمت محاول | Background : Behcet’s disease is a systemic disorder where its etiopathogenesis is not well determined. The commonest manifestations are muccocutaneous but can involve eye, cardiovascular and neurological systems. There are many modalities of therapy topical and systemic.Isotretinion has been tried as an effective therapy of muccocutaneous manifestations. In present work was to try a new retinoid like acitretin which has longer half life than isotretinoin.Aims of the study : To evaluate the effectiveness of oral acitretin versus oral zinc gluconate in the treatment and prophylaxis of Behcet’s disease as a new therapeutic model.Materials and methods : This cross over controlled therapeutic study that conducted in the Department of Dermatology - Baghdad Teaching Hospital the period from August 2013 - May 2014.Twenty patients with fulfilled criteria of Behcets’s disease was included in this work. History and full examination were done for all patients regarding all demo - garaphic points related to the disease. They were given acitretin 25 mg orally once daily for three months to be seen on the day fourteenth firstly and then monthly to be assessed depending on the clinical manifestation index for Behcets disease. After three months, acitretin was stopped and patients were given zinc gluconate 25 mg twice daily for another three months. Results : Twenty patients were treated 12 males (60%), and 8 females (40%), with male to female ratio 1.5 : 1. All these patients completed the study and their ages ranged between 20 - 59 years with mean± SD (37.3±12.3). Pathergy both ordinary and oral were also minimized by this therapy while C - reactive protein was not much effective by this therapy. Zinc gluconate also had the same therapeutic action against these manifestations. Clinical manifestations index before treatment ranged between 1 and 11 with mean ± SD of 5.65±1.98.After acitretin therapy the mean of CMI started to decline to reach 2.65 ±2.03 in first month of the therapy with (p=0.00001) which was statistically high significant and continued high significant till the end of the third month with (p - value > 0.000001). After cessation of acitretin and zinc gluconate started the mean continued to decrease to reach 2.05±2.52 at the end of the first month with (p=<0.000001) which was statistically high significant then; started to increase to reach 3.3 ±2.31 at the end of six month of the therapy but statistically remained high significant (p - value=0.0007). Both acitretin and zinc gluconate have statistically significant effect in reducing severity and frequency of oral ulcers, genital ulcers, skin and rheumatologic manifestations. Conclusions : oral acitretin was found to be an effective therapy in addition to its prophylactic action in treatment of muccocutaneous manifestations of Behcet,s disease. Also zinc gluconate had effective therapeutic action against these features of Behcet’s disease.

تاثــير مستوى الاسترادايول والبروجستيرون في اللعاب على حالة صحة الفم عند النساء اثناء الحمل == Effects of Salivary Level of Estradiol And Progesterone On Oral Health Status In Women During Pregnancy

اسم المؤلف: زينة كامل كاظم
اسم المشرف: هاجر ابراهيم عبد الله
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الحمل هو حالة فسيولوجية تجلب مجموعة واسعة من التغييرات في حياة المراة، بما في ذلك التعرض لامراض اللثة، ربما بسبب التغيرات الهرمونية المرتبطة مع الحمل. قد تؤثر الهرمونات الجنسية على اغشية الفم واللثة وربما هذا يؤدي الى العديد من الامراض اللثوية. ان هرمونا | Pregnancy is a physiological state that brings a wide range of changes in a woman’s life, including a susceptibility to gingival disease, probably due to hormonal changes associated with pregnancy. These female sex hormones may modify the oral mucosa and may lead to various degrees of gingival inflammation. The hormonal changes occurring during pregnancy may be associated with pregnancy gingivitis and gingival bleeding. Sex hormones are specific regulatory molecules have long been considered to play an influential role on periodontal tissues especially gingiva, bone turnover rate, wound healing and periodontal disease progression. Aims of the study1. Assessment of oral hygiene level and dental status in both second and third trimester pregnant women and compares results.2. Assessment salivary hormonal levels of endogenous female sex steroids in both second and third trimester pregnant women and compares results.3. Comparison of oral health status and endogenous female sex steroids salivary hormonal levels between gingivitis and non - gingivitis subgroups of both second and third trimester pregnant women groups.4. Find out the association between the gingival health status and salivary hormonal levels of endogenous female sex steroids (Estradiol and progesterone).Materials and methods This study was carried out on seventy - eight pregnant women who were attended for routine and regular follow up visits in obstetrics and gynecology department at Al - Yarmouk Teaching Hospital, from February 2013 to July 2013. This study was approved by the scientific committee in the department of oral medicine college of dentistry Al - Mustansiriya University. They were divided according to gestational age in to second trimester group and third trimester group. Fifty pregnant women (age range 18 - 38 years) and at gestational age was ranged between (20 - 27 weeks) were recruited as 2nd trimester group and Twenty - eight pregnant women (age range 18 - 39 years) at gestational age ranged between (28 - 33 weeks) were recruited as 3rd trimester group and according to Loe and Silness gingival index these two groups subdivided into gingivitis and non - gingivitis groups. Oral clinical examination including an assessment of gingival inflammation (Loe and Silness Gingival Index), Plaque amount (Silness and Loe Plaque Index), dental status (Decayed Missing Filling Teeth), and salivary flow rate (SFR) had also been done. Samples of whole unstimulated (resting) saliva were collected from all participants then investigated for sex steroids salivary hormonal levels of Estradiol, Progesterone. Results and discussion Oral health measurements including : GI, PLI, SFR and DMFT showed no significant difference between 2nd trimester and 3rd trimester groups. Sex steroids salivary hormonal levels of Progesterone showed a significant difference with higher mean value in 3rd trimester pregnant women than 2nd trimester pregnant women while sex steroids salivary hormonal levels of Estradiol showed no significant difference between two groups. Comparisons between gingivitis and non - gingivitis subgroups of 2nd trimester pregnant women group showed that there was highly significant difference in SFR with higher mean value in non - gingivitis group, and there was highly significant difference in PLI with higher mean value in gingivitis group, DMFT showed non - significant difference between the subgroups and (Estradiol and progesterone) salivary hormonal levels showed highly significant difference with higher mean values in gingivitis group. Comparisons between gingivitis and non - gingivitis subgroups of 3rd trimester pregnant women group showed that there was a non - significant difference in SFR, DMFT and a highly significant difference in PLI with higher mean value in gingivitis group, while progesterone salivary hormonal levels showed non - significant difference and Estradiol salivary hormonal levels showed a highly significant difference with higher mean value in gingivitis group. Comparison of GI between gingivitis groups of both 2nd and 3rd trimester pregnant women showed that there was a significant difference with higher mean value in 3rd trimester. Estradiol and progesterone salivary hormonal levels were non - significantly correlated with PLI and GI for gingivitis and non - gingivitis group of 2nd trimester pregnant women. Progesterone salivary hormonal level was non - significantly correlated with PLI and GI for gingivitis and non - gingivitis group of 3rd trimester pregnant women while Estradiol salivary hormonal level was non - significantly correlated with PLI and GI for non - gingivitis group and significantly correlated with PLI and GI for gingivitis group. GI and PLI for gingivitis groups of both 2nd and 3rd trimester revealed that there was a highly significant correlation.Conclusions Female Sex steroids hormones (Estradiol and Progesterone) salivary hormonal levels significantly increase from the second to the third trimester especially Estradiol and Play an important role in influencing gingival inflammation during pregnancy. These hormones are neither necessary nor sufficient to produce gingival changes by themselves. However, they may alter periodontal tissue responses to microbial plaque and thus indirectly contribute to gingivitis. Dental status in pregnant women is not significantly different between 2nd and 3rd trimester pregnant women groups. Women should be offered training in good oral hygiene habits, and community awareness programs should be conducted to increase their awareness of the crucial importance of such habits especially during pregnancy

التاثيرات الدوائية لمادة - كاپا كراجينان - في مهنية طب الاسنان : دراسات داخل وخارج الانبوب == The Pharmacological Effects of Kappa Carrageenan In Dental Practice : An In Vitro And In Vivo Studies

اسم المؤلف: اسيل جاسم علي
اسم المشرف: هاجر ابراهيم عبد الله | مروان صالح النمر
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: كاراجينان هومركب يحتوي على پولي كلايكان الكبريتي وهو مستخلص من الطحلب الاحمر. الكراجين بطبيعته الغروية المائية يمتلك خواص هلامية,مثخنة ومستحلبة تسمح باستخدامه بكثرة في الصناعات الغذائية,مستحضرات الصحة الفموية والكماليات.وبسبب مركباته الحياتية الفعالة فقد

Evaluation of the Involvement of the Tempromandibular Joint in Patients with Osteoarthritis and the Accuracy of Ultrasonography as Compared to Computed tomography for Detection of Osteoarthritic Changes.

اسم المؤلف: احمد عادل عثمان
اسم المشرف: هاجر ابراهيم عبد الله
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: خلفية البحث : اضطرابات المفصل الفكي الصدغي تشير الى مصطلح مركب يحتوي على عدة حالات تتضمن المفصل الصدغي ,التركيبات المحيطة او كلاهما , تظهر على شكل الم في منطقة المفصل والعضلات المرتبطة,وتحدد بالقدرة على الحركة الطبيعية مثل المضغ, الكلام والبلع. مرض التهاب | Tempromandibular joint disorders is a collective term embracing a number of conditions affecting the TMJ, the surrounding structures or both,manifested by pain in the area of joint and associated muscles, and limitation in the ability to make normal movement like mastication,speech and swallowing. Osteoarthritis is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. A variety of causes—hereditary, developmental, metabolic, and mechanical deficits may initiate processes leading to loss of cartilage. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may undergo atrophy, and ligaments may become more lax.Objective of the study : • To determine the extent of tempromandibular joint involvement in patients with osteoarthritis.• To evaluate the correlation between clinical and radiographical findings. • To evaluate the accuracy of sonography in detection of osteoarthritic changes compared to Computed tomography.Materials and method : A comparative study had been done using thirty six symptomatic patients(24 female and 12 male) above 40 years diagnosed as osteoarthritis by specialist rheumatologist in Alkarkh general hospital, with clinical finding related to osteoarthritis like pain,tenderness,crepitation, clicking and limited mouth opening. these patients were exposed to computed tomography(CT) scan (Philips - Brilliance 64) in Al - Karkh general hospital and then the results were compared with sonographic findings (Philips 12.5 MHz transducer) to see the disc displacement, effusion, erosion, flattening, osteolytic and osteophytic lesions in the condylar head.The period of the study started from (october - 2013 to june - 2014).Results : The result of the study showed that the mean age of osteoarthritic patients was (49.69) years, and female percentage (66.7%) and male(33.3%). Chief complaine showed more predilection in the left side (28%) and bilateral showed(56%).Clinically : limitation in mouth opening (50%),crepitation(36.11%), clicking (27.7%), and tenderness (20.8%). Radiographically Computed tomography(CT) scan showed disc displacement (50%), joint effusion (37.5%), flattening(36.11%), osteophyte(18,05%), and erosion(11.1%). There was significant correlation between clicking and joint effusion in computed tomography(CT),while tenderness showed significant correlation with osteophyte and joint effusion in sonography. Other correlations were non significant correlation between clinical and radiological changes. Association between computed tomography(CT) and sonography showed fair agreement in osteophyte detection,fair agreement in joint effusion,moderate agreement in detection of joint erosion,moderate agreement in reduction of space and anterior disc displacement and also moderate agreement in condylar head flattening. Conclusions : Osteoarthritis in tempromandibular joint may be unilateral or bilateral. About 50% of Patients with osteoarthritis have limitation in mouth opening. Clinical findings play a major role in diagnosis of osteoarthritis. The tempromandibular joint changes in osteoarthritis were the results of degenerative processes, in contrast to rheumatoid arthritis were the changes as a result of the disease. Sonography was more likely to be sensitive rather than specific in detection of osteoarthritic changes

الظهور الكيميائي النسيجي المناعي للاوستيوكالسين، OC عاملا لنمو المحول بيتا واحد TGF - B1 وبروتين الشكل العظمي سبعة BMP - 7 في خلل التنسج الليفي والورم الليفي المعظم في عظام الفك : دراسة مقارنة == Immunohistochemicalexpression of Osteocalcin, Transforming Growth Factor Beta - 1And Bone Morphogenetic Protein - 7 In Fibrous Dysplasia And Ossifying Fibroma of The Jaw Bones Acomparative Study

اسم المؤلف: فرح غسان ابراهیم
الموضوع العام: طب الاسنان
السنة: 2014
الدرجة: ماجستير
الجامعة: جامعة بغداد
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Fibrous Dysplasia & Ossifying Fibroma of the jawsare maxillofacial fibroosseous lesions sharing anoverlapping clinicopathological characteristics. This can be diagnostically challenging for pathologists& surgeons. It is important to make the distinction because of differences in their clinical behavior, modes of treatment and prognosis.Osteocalcin is an immunohistochemicalmarker; secreted by osteoblasts and its high serum levelsare correlated with increased bone mineraldensity. It is therefore, used as biomarker for boneformation process and also has a role in regulationof osteoblast function.Transforming growth factor beta - 1 is a multifunctional regulator of cell growth which will either stimulate or inhibit proliferation of mesenchymal cells depending on the presence of other growth factors. It is secreted by osteoblasts and is very abundant in bone matrix. Bone morphogenetic protein - 7is a member of transforming growth factor - b superfamily; it is widely expressed during embryonic growth, and is an essential morphogen in renal, skeletal, and eye development.Aims of the study : This study aimedto evaluate and compare the Immunohistochemical expression ofosteocalcin, transforming growth factor beta - 1 andbone morphogenetic protein - 7in the pathogenesis of Fibrous dysplasia and Ossifying fibroma of the jaw bones,correlate the expression of the aforementioned markers in these lesions.Analyze theimmunohistochemical expression ofosteocalcin, Transforming growth factor beta - 1 & bone morphogenetic protein - 7 inFibrous dysplasia & Ossifying fibroma, in order to assess its potential role in differentiation between these two disease entities.Materials&Methods : A total of 30 retrospective formalin - fixed, paraffin - embedded tissue blocks were included in this study, 15 were diagnosed asFibrous dysplasia of the jaws and 15 were ofOssifying fibroma of the jaws. Animmunohistochemicalstaining method using ofosteocalcin,transforming growthfactor beta - 1 andbone morphogenetic protein - 7 monoclonal antibodies were performed.Results : The results revealed that the majority of cases (73.33%) were females for each Fibrous dysplasia &Ossifying fibroma. the age range was (8 - 35)years for Fibrous dysplasia and (7 - 50)years forOssifying fibroma. For Fibrous dysplasia most cases presented in maxilla (66.76%) while for Ossifying fibroma most of the cases presented in mandible (73.33), with more predominant Fibrous dysplasia cases in molar area (60%) and more presented Ossifying fibroma cases in premolar & molar area (33.33%). Statistically significant difference was found between Fibrous dysplasia&Ossifying fibroma cases regarding jaws & site distribution (P=0.02&0.04) respectively.Osteocalcin positive immunohistochemicalexpression was found in fibroblast - like cells in 4 cases(26.66%) of Fibrous dysplasia and in 7 cases (46.67%) of Ossifying fibroma, according to Chi - square test the result showed statistically significant difference regarding osteocalcin expression in Fibrous dysplasia &Ossifying fibroma (P=0.04). Transforming growth factor beta - 1 was positivelyexpressed in 8cases (53.3%) of Fibrous dysplasiaand 10 cases (66.67%) of Ossifying fibroma. Bone morphogenetic protein - 7showed positive expression in 2 cases (13.3%) of Fibrous dysplasia and 4 cases (26.7%) ofossifying fibroma.Statistically non - significant difference regarding the immunohistochemicalexpression of transforming growth factor beta - 1 and bone morphogenetic protein - 7in Fibrous dysplasia &Ossifying fibroma. Moreover significant correlation was found regardingtransforming growth factor beta - 1 expression in response to bone morphogenetic protein - 7in Fibrous dysplasia (P=0.03)and osteocalcin expression in response totransforming growth factor beta - 1 in Ossifying fibroma (P=0.01).Conclusions : Transforming growth factor beta - 1 expressin the majority of Fibrous dysplasia &Ossifying fibroma cases indicate its important role in the process of osteogenesis. The significant correlation seen regarding the expression of some of the studied markers with each other suggest their cooperative role in the pathogenesis of Fibrous dysplasia &Ossifying fibroma