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العلاقه مابين تعدد الاشكال الجينيه لجين السمنه وكثافة الدهون مع مقاومة الانسولين لدى مرضى السكري من النوع الثاني Polymorphism of Fat Mass and Obesity Associated Gene and its Correlation with Insulin Resistance in Type2 Diabetic Patients

اسم المؤلف: ضحى هداوي السفاح
اسم المشرف: فاضل جواد ال طعمة
الموضوع العام: علوم الكيمياء
السنة: 2019
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: ماجستير
الجامعة: جامعة كربلاء - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: كربلاء

طريقة كروماتوغرافية طيفية جديدة - لتقدير عقار اللوراتادين في بعض المستحضرات الصيدلانية Anew Chromatographic - Spectrophotometric Method for Determination of Loratadine in Some Pharmaceutical Preparations

اسم المؤلف: صفاء حكيم ناصر الغزاوي
اسم المشرف: محمد تركي خثي
الموضوع العام: علوم الكيمياء
السنة: 2019
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: ماجستير
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: ذي قار
المستخلص: Due to the medicinal significance of Loratadine, ethyl4-dihydro-11H benzo [5,6] cyclohepta [1,2-b] pyridin-11ylidene (-1-piperidinecarboxylate) has been devoted to this message To create a new chromatographic-spectral method for estimating the pure drug and the drug found in a number of its pharmaceuticals. | The letter included a detailed explanation of a new chromatographic-spectral method for estimating amounts of pure and commercial loratidine. The principle of this method is to break down the double bond present in the loratadine by the potassium permanganate oxidant factor of 0.05 molar and convert it into two ketone-containing compounds : 8-Chloro-5,6-dihydro-11H-benzo [5,6] cyclohepta [1,2-b The second compound is ethyl-4-oxopiperidine-1-carboxylate (B). It has been shown that the two compounds (A and B) can be separated by TLC, FTIR, separated and completely isolated by column chromatography technique. After the separation, the compound (A) was given a stable colorant complex with 4-amino acid benzoic acid ester, in a acidic medium, While the compound ( B ) did not give a stable complex. The results showed a study of changing the conditions of the process of analysis and separation of the two compounds and their diagnosis and the formation of the resulting complex and applications of the method and discussed with the use of different quantities of many types of acids and strong and weak rules and indicate their impact on the intensity of the complex complex color and the optimal conditions were selected for his way of work.

التاثير الوقائي للخلاصة المائية لاوراق نبات الزريج STZ على الكبد واعتلال الخصوبة في ذكور الجرذان المصابة بالسكري بواسطة Potential Role of Aqueous Extract From Chrozophora Tinctoria Leaves on Liver and Fertility Dysfunction in STZ Induced Diabetic Male Rats

اسم المؤلف: منى حسون عبودي
اسم المشرف: محمد عجة عودة
الموضوع العام: علوم الكيمياء
السنة: 2019
الموضوع الدقيق: الكيمياء التحليلية الحياتية
الدرجة: دكتوراه
الجامعة: جامعة ذي قار - كلية العلوم - قسم الكيمياء
اللغة: الانكليزية
مكان الجامعة: ذي قار
الصفحات الاولى:
المستخلص: This study was designed to investigate the pharmacological effects on air dried Chrozophora tinctoria (L.) Rafin plant samples as well as the responses of streptozotocin (STZ)-induced diabetic rats for the aqueous Chrozophora tinctoria (L.) Rafin leaves extracts. To achieve this aim, phytochemicals analysis were carried out by various standard assays and then antioxidant compounds contents in the three parts of the plant (leaves, stems, and roots) estimated by common spectroscopic methods. In addition, physiological, biochemical and histological parameters of (STZ) diabetic rats are evaluated too. Rats are distributed into five groups : Control, diabetic rats and three diabetic groups received orally different doses of (50, 70, and 90 mg/kg body weight (BW)) from the target extract for a period of 35 days. When the therapy is ended, blood samples, liver and testis tissues were taken and concentration of glucose, insulin, lipid profile, HbA1C, as well as the activity of ALT, AST, ALP, male sexual hormones were determined as well as liver and testis histology. In general, the results of this study show that the liver and testis tissue were damaged, serum ALP, AST ALT activities, HbA1C, lipid profile, T, LH, FSH, insulin and blood glucose levels were remarkable normalized. It was observed that the BW of diabetic control group is decreased. However the BW elevated slightly in the diabetic treated groups as well as serum insulin and male hormones. In addition, the extract improves the liver function and reduces lesions associated with diabetic state in STZ induced rats. Moreover, the effect of oral administration of Chrozophora tinctoria (L.) Rafin at a dose of 90 mg / kg body weight was more efficient than the 50 and 70 mg/kg body weight. Furthermore, the obtained results related that male reproductive system showed remarkable increased of sperm count, viability and motility after treatment with dose 70 mg/kg of body weight. Histological examination of the testis revealed improvement of spermatogenesis and Leydig cell proliferation with all doses of the extract. However, the histological features of the rats testis received 70 and 90 mg/kg, was found to be similar to the healthy group. The whole results indicated that the extract exhibited protective effect on liver tissues, as well as maintained the damage fertility in diabetic rats. These investigations explain its potentials as an antidiabetic, hepato protective agent, and promising therapeutic to recover male subfertility