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طريقة كروماتوغرافية طيفية جديدة - لتقدير عقار اللوراتادين في بعض المستحضرات الصيدلانية == Anew Chromatographic - Spectrophotometric Method for Determination of Loratadine in Some Pharmaceutical Preparations
Author name:
صفاء حكيم ناصر الغزاوي
Supervisor name:
محمد تركي خثي
General topic:
Chemistry
Specific topic:
Analytical Biochemistry
Degree:
Master
University:
University of Thi-Qar - College Of Science - Chemistry Department
Language:
English
University location:
Dhi Qar
Abstract:
Due to the medicinal significance of Loratadine, ethyl4-dihydro-11H benzo [5,6] cyclohepta [1,2-b] pyridin-11ylidene (-1-piperidinecarboxylate) has been devoted to this message To create a new chromatographic-spectral method for estimating the pure drug and the drug found in a number of its pharmaceuticals. | The letter included a detailed explanation of a new chromatographic-spectral method for estimating amounts of pure and commercial loratidine. The principle of this method is to break down the double bond present in the loratadine by the potassium permanganate oxidant factor of 0.05 molar and convert it into two ketone-containing compounds : 8-Chloro-5,6-dihydro-11H-benzo [5,6] cyclohepta [1,2-b The second compound is ethyl-4-oxopiperidine-1-carboxylate (B). It has been shown that the two compounds (A and B) can be separated by TLC, FTIR, separated and completely isolated by column chromatography technique. After the separation, the compound (A) was given a stable colorant complex with 4-amino acid benzoic acid ester, in a acidic medium, While the compound ( B ) did not give a stable complex. The results showed a study of changing the conditions of the process of analysis and separation of the two compounds and their diagnosis and the formation of the resulting complex and applications of the method and discussed with the use of different quantities of many types of acids and strong and weak rules and indicate their impact on the intensity of the complex complex color and the optimal conditions were selected for his way of work.
