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دراسة التاثير العلاجي لحليب الافراس المخمر للتقليل من تاثير الاجهاد التاكسدي المستحدث بواسطة خلات الرصاص في الجرذان البيض == Study The Therapeutic Effect of Fermented Mare? S Milk To Reduce The Effect of Oxidative Stress Induced By Lead Acetate In White Albino Rats

اسم المؤلف: شيماء عباس صبيح
اسم المشرف: كريم ناصر طاهر
الموضوع العام: الطب البيطري
السنة: 2015
الموضوع الدقيق: الصحة العامة
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية الطب البيطري
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: اجريت الدراسة الحالية في البيت الحيواني التابع لكلية الطب البيطري / جامعة القادسية بهدف تقييم الدور العلاجي لحليب الافراس المخمر في التقليل من تاثير الاجهاد التاكسدي المستحدث بواسطة خلات الرصاص. استخدم في هذه الدراسة ( 40 ) ذكر من الجرذان البيضاء نوع ( w | The present study was conducted at the animal house of veterinary medicine college of AL - Qadisiyah University during the period from 27 - 2 - 2014 to 30 - 3 - 2014. to evaluate the productive role of fermented mare's milk in to reduce the oxidative stress that induced by lead acetate , 40 male albino rats weighing between 200 - 210 gm were used in this study. the animals were obtained from the animal house of veterinary medicine College / Baghdad University. The animals were randomly distributed into four equal groups , ( 10 rats per each group / cage) as follow : - Control group : The rats were given only basal diet and deionized drinking water - - First treatment group ( T1) : The rats were given basal diet and deionized drinking water that contain 1000 ppm lead acetate for 30 days. - Second treatment group ( T2 ) : The rats were administrated basal diet and deionized drinking water that contained 1000 ppm of lead acetate and received orally ( by gavag ) fermented mare's milk at a dose ( 10ml / kg b.w / day ) for 30 days. - Third treatment group (T3) : The rats were given basal diet and deionized drinking water that contained 1000 ppm of lead acetate and received orally ( by gavag ) EDTA at a dose ( 50 mg/ kg b.w / day ) for 30 days. At the end of the experiment all the animals were fasted for ( 12 hours ) and then killed animals from each treatment group blood samples were collected from the heart to measures some blood parameters such RBC , Hb and PCV and biochemical parameters such as liver function parameters ( total protein and activity of some enzymes such as ALT , AST , ALP and LDH ) , kidney function parameters such as Urea and Creatinine concentration and oxidative stress parameters such as GSH , SOD , MDA ). In addition to that study the histopathological changes of liver and kidney tissues were studied The results of the present study can be summarized as follow : - 1 - Blood parameters : The results of the statistical analysis showed that there was a significant ( p < 0.05 ) decrease in the mean values of RBC , Hb , and PCV in a group treated with lead acetate only ( T1 ) as compared to other experimental groups. while groups treated with EDTA and fermented mares milk showed a significant ( p < 0.05 ) improvement in blood parameters. 2 - Biochemical parameters : A - Liver function parameters : The result revealed that there was a significant ( p < 0.05 )effect of lead acetate on level of total protein where caused a decrease in total protein concentration and increase the in activity of ALT , AST , ALP , and LDH as compared to other experimental groups. Yet treatment with fermented mare's milk ( T2 ) resulted in an increase in the total protein concentration and a decrease in the activity ALT , AST , ALP AND LDH. Also treatment with EDTA ( T3 ) caused a similar results to ( T2 ). B - Kidney function parameters : The results obtained in this study demonstrated that a significant ( p < 0.05 ) increase in the level of urea and creatinine in a group of animals treated with lead acetate only ( T1) , while using fermented mare's milk ( T2 ) and also EDTA contributed reduction in the level of urea and creatinine 3 - Oxidative stress parameters : The results of the present study showed that there was a significant ( p < 0.05) decrease in the concentration of GSH and SOD a significant ( p < 0.05 ) increase in MDA concentration in animals that administrated lead acetate only ( T1) while administration fermented mare's milk and EDTA resulted in significant ( p < 0.05 ) increase in the concentration of GSH and SOD while a significant ( p < 0.05 ) reduction in MDA concentration. The values becomes close to the concentration of the control group. 4 - Histopathological changes : The results of Histopathological examination for tissues of liver and kidney of rats given lead acetate alone ( T1 ) showed that there was a clear Histopathological changes presented in degeneration of hepatocytes and congestion in central vein which associated with hemorrhage in liver and kidney tissues of animals administrated fermented mare's milk showed normal and free from congestion.

استخدام حليب الافراس المخمر في علاج قرحة المعدة المستحدثة بالاسبرين في اناث الجرذان البيضاء == Usage of Fermented mareP,Ps Milk In Treatment of Aspirin Induced Ulcer In Female Albino Rats

اسم المؤلف: اسراء طاهر مسلم العبيدي
اسم المشرف: كريم ناصر طاهر | علي محمد غازي
الموضوع العام: الطب البيطري
السنة: 2015
الموضوع الدقيق: الصحة العامة
الدرجة: ماجستير
الجامعة: جامعة القادسية - كلية الطب البيطري
اللغة: العربية
مكان الجامعة: القادسية
الصفحات الاولى:
المستخلص: This study was carried out at the animal house of veterinary medicine College /AL - Qadisiya university during the period from 27 - 6 - 2014 to 27 - 3 2014 the study aimed to investigate the effect of usage fermented mareP P s milk on the healing of gastric ulcer induced by aspirin. A total of 56 female albino rats weighing between 200 - 250g were used in this study.. The animals were divided randomly in to four equal groups each groups comprising of 14 females per each group.Untreated group or negative control groups (C) : were received standard diet and distilled water only.treated groups : - positive control group (T1), second treated group ( T2) and Third treated group (T3). All animals of these groups were induced ulcer by administrated orally(100mg/kg b.w ) aspirin drug for one week ,Then two animals from each group were sacrificed after 7 days to ensure that ulcer induced,after that the animals of second treatment group(T2) were given orally by gavage fermented mare P Ps milk at dose(10ml/kg b.w) once daily for three weeks consecutive while animals of third treatment group (T3) were treated oraly by gavage rantidine (50mg/kg b.w) once daily for three consecutive weeks, four animals per each group were sacrificed at the end of each week، and the stomach were excised to measures the ulcer parameters (ulcers score, ulcer index,ulcerinhibition percentage and PH of gastric juice value) blood samples were collected from all animals from the heart for blood test parameters (red blood cell count , hemoglobin concentration and packed cell volume).Biochemicals parameters such as alanine trans amines(ALT), aspartate trans amines(AST),alkaline phosphatase (ALP) total protein ,urea and creatinine and oxidative stress parameters such as malondialdehyde (MDA), superoxide dismutase(SOD),glutathione, (GSH), and prostaglandin (PGER2R).in addition tohistological examination to ensure the exist of ulcer. The results of this study revealed the following : ulcer parameters : the result of this study revealed that administration of aspirin produced formation multi - ulcer in the stomach wall besides causes different changes in the studied parameters al so, the result has been shown a significantly ( P<0.05) increase in the ulcer score and ulcer index in aspirin administration groups (T1)in Comparison with other experimental groups during the three weeks of the experiment on the other hand aspirin administration causes a significant (P<0.05) reduction in pH value of gastric juice , at the same time given fermented mare ,s milk improvement for the previous parameters and causes a significant (P<0.05) decrease in it along the three weeks of experiment as well as causes a significant (P<0.05) increase in ulcer inhibition ( %) and the pH value of gastric juice ,these values were closed to the values of ranitidine treated group (T3) and control groups respectively.Blood parameters : the result of the present study revealed that there was a significant ( P<0.05) decrease in the total count of RBC ,Hb concentration and PCV in aspirin administration group (T1) as compared to the other experimental group along the three weeks of experiment. while given fermented mar P Ps milk causes improvement in the previous parameters and produce a significant (P<0.05) increase of these parameters and became close to the values of rantidine groups and negative control groups.Biochemicals parameters : The result indicated that administration of aspirin produced a significant (P<0.05) increase in ALT,ASTand ALP activity as compared to the othe experimental groups but causes a significant (P<0.05) decrease in concentration of total protein particularly in the third weeks of experiment ,while giving fermented mare P,Ps milk causes improvement the previousparameters and causes a significantly (P<0.05) reduction in it and became close to the values of rantidine groups and negative control groupsOxidative stress parameters : the result of the present study revealed that there was a significantly( P<0.05) increase in (MDA concentration) and significantly( P<0.05) decrease in the concentration of (SOD,GSH and PGE2) in aspirin treated groups ,while giving fermented mare ,s milk causes a significantly( P<0.05) decrease in concentration of MDA and a significantly (P<0.05) increase in the concentration of( SOD ,GSH ,PGE2) these result are closed to the result of rantidine treated groups and negative control group.the result also shown there were non significant differences in concentration of urea and creatinine along experimental weeks among different groups ,on the other hand, the results of the histological examination of aspirin treated groups that a pathological changes in the stomach tissue represented in formation ulcers , congestion and bleeding.while giving fermented mare's milk contributes in the active form in hide of ulcers in the stomach wall, hemorrhage signs and congestion similar results obtaining when treated with rantidine.it could be concluded that aspirin administration causes negative effect on stomach also the study has been showed the important role of fermented mare's milk in reduction damages and negative effects of aspirin.

دور مستويات مختلفة من الانزيمات المحللة للالياف Fibrolytic Enzymes على اداء الحملان الذكرية العواسية == The Role Of Different Levels Of Fibrolytic Enzymes On The Performance Of Awassi Ram Lambs

اسم المؤلف: علي مهدي محمود ماني
اسم المشرف: مظفر نافع رحو الصائغ | ضياء عبد الامير الخياط
الموضوع العام: الطب البيطري
السنة: 2015
الموضوع الدقيق: الصحة العامة
الدرجة: دكتوراه
الجامعة: جامعة بغداد - كلية الطب البيطري
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى: