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تحضير وتشخيص ودراسة الفعالية المضادة للبكتريا لبعض مشتقات البايرازول الجديدة

Author name: ايهاب حامد محمد

Supervisor name: عزت حسين زمام

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

تحضير وتشخيص ودراسة الفعالية الحيوية لبعض مشتقات البيريميدين الجديدة ابتداء من حامض الميلدرم

Author name: رنا نعمة عطية

Supervisor name: ناجي موسى علي

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

تحضير وتشخيص ودراسة الفعالية الحيوية لبعض المشتقات الجديدة للبيتا لاكتام

Author name: رضية عبد الباقي خضر

Supervisor name: عزت حسين زمام

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

تحضير وتشخيص بعض قواعد مانخ ودراسة التطبيقات التحليلية لبعض مشتقاتها

Author name: بشائر جبار حسين

Supervisor name: احمد ثامر سالم

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

تحضير وتشخيص بعض المركبات الحلقية غير المتجانسة من وسطيات نتروجينية

Author name: سارة محمد عبد علوان

Supervisor name: حسن ثامر غانم

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Najaf

تحضير وتشخيص بعض المركبات الحلقية غير المتجانسة من 8-هايدروكسي كوينولين

Author name: رباب مهدي عبيد

Supervisor name: حسن ثامر غانم

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Najaf

بعض المركبات الحلقية غير المتجانسة لمركبات الزانثهيدرول وتقييم النشاط الحيوي لبعض المركبات المحضرة

Author name: وسام طاهر مسلم

Supervisor name: احمد ثامر سالم

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

Synthesis of New Crown Ether and Study the Application in Phase Transfer Catalyst

Author name: احسان عبد الحسين هاتف

Supervisor name: كريم جابر صباح

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

Synthesis and characterization of biopolymer nano composite based on modified clay using organic nitrogen compounds

Author name: منار غياث عبد المطلب

Supervisor name: عماد عباس جعفر الملا | ماجد جاري محمد

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

Preparation, Identification, and Studying of Biological Activity for New Formazan Compounds

Author name: ضحى راهي كشاش الشباني

Supervisor name: نغم محمود جواد

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: English

University location: Najaf

تحضير وتشخيص ودراسة بعض الخواص الحرارية لبوليمرات الماليئيمايد تحتوي على ادوية سلفا == Synthesis, Characterization and Thermal Study of Some New Maleimide Polymers Contain Sulfa Drugs

Author name: احمد وحيد راضي

Supervisor name: عزت حسين زمام

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

First pages:

تحضير وتشخيص ودراسة الفعالية الحيوية لبعض المشتقات الحلقية غير المتجانسة الجديدة من حامض الكومارين-3- كاربوكسيليك == Synthesis, Characterization and study Biological activity of Some New Heterocyclic derivatives from Coumarin - 3 - Carboxylic acid

Author name: علاء فاضل رزاق

Supervisor name: ماجد جاري محمد

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

First pages:

تحضير وتشخيص لبعض المركبات الحلقية غير المتجانسة الجديدة من دواء السلفاديازين == Synthesis and Identification of some new heterocyclic Compounds from sulfadiazine drug

Author name: صبا جميل يوسف

Supervisor name: نادية صادق مجيد

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Najaf

First pages:

تحضير وتشخيص ودراسة الفعالية البايولوجية لبعض المشتقات الحلقية غير المتجانسة الجديدة من 2 - امينو ثيازول

Author name: زينب محسن بديوي

Supervisor name: حسن ثامر غانم

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Najaf

First pages:

تحضير وتشخيص بعض المركبات الحلقية غير المتجانسة الجديدة من 2,6 ثنائي امينو 4 - هايدروكسي بيريميدين == Preparation and Characterization of some new Heterocyclic Compounds from 2,6 diamino 4-hydroxy pyrimidine

Author name: اسيل فاضل كريم

Supervisor name: حسن ثامر غانم

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Najaf

First pages:

تحضير وتشخيص ودراسة الفعالية الحيوية لمشتقات الكلوكوز الكلايكوسيدية الجديدة == New Glucoside Derivatives Synthesis, Characterization and Biological Activity

Author name: مصطفى كاظم نعيم

Supervisor name: عزت حسين زمام

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

First pages:

تحضيرو تشخيص والفعالية الحيوية لبعض المشتقات الجديدة للبيتا لاكتام ثنائية الحلقة لسكر D- مانيتول == Synthesis , Characterization and biological activity of some new bis ?-lactam derivatives from D-mannitol

Author name: ايمان عبد الوهاب عبد الله الكويتي

Supervisor name: عزت حسين زمام

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

تحضير وتشخيص بعض كلايكوسيدات 3,2,1- ترايازول الجديدة بواسطة كيمياء النقرة == Synthesis and Characterization of Some New 1,2,3-triazole glycosides via click chemistry

Author name: زياد كاظم عليوي

Supervisor name: عزت حسين زمام

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: English

University location: Najaf

تحضير ودراسة الفعالية الحيوية لبعض مشتقات السلفايد والسلفون == Synthesis , Identification and Biological Activity for (Sulfide ,Sulfone) - Compounds

Author name: رشا نعمة حسين الجعباوي

Supervisor name: نغم محمود جواد الجمالي

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Najaf

First pages:

Abstract: Sulfone and Sulfide are important compounds due to their uses in industrial , artificial and pharmaceutical applications . They are characterized by their effectiveness against skin diseases and fungal what make them used as biologically important substances and preparatory studies have been extended to their derivatives. The research includes two sections : Section I : : contains preparing 19 compound which are (R1 - R19) in six parts : : - Part one : - includes preparing compound (R1) from the interaction of (Thio semicarbazide) with (Diethyl Terephthalate) interacting the resulted (R1) react with (10% Sodium hydroxide ) to prepare the compound (R2), interacting the resulted compound with (chloro ethyl acetate) to prepare the compound (R3) , and finally interacting the resulted compound with acetic acid and hydrogen peroxide to prepare compound (R4). Part two : - includes preparing compound (R5) by interacting compound (Sulfobenzoic anhydride) with (2 - amino - 5 - mercapto - 1,3,4 - thiadiazole) then the resulting interaction (R5) with( chloro ethyl acetate) to prepare the compound (R6) , and interacting the result with (acetic acid) and (hydrogen peroxide) to prepare compound (R7).Part three : - : includes preparing compounds (R8, R9, R10) by interacting (phenylene diamine) with (2 - mercapto acetic acid) to produce (R8) and reactance of this compound with Formaldehyde)) to form a compound (R9) and interacting the last compound (acetic acid) and (hydrogen peroxide) to prepare compound (R10). Part four : - includes interacting (2 - amino - 5 - mercapto - 1,3,4 - thiadiazol) with a compound formaldehyde)) to prepare the compound (R11) , interacting compound R11 and interacting the result with (Sulfobenzoic anhydride to produce compound (R12). Part five : - : includes preparing compounds (R13,R14, R15, R16) by interacting compound (Formaldehyde) with (2 - mercapto benzoic acid) to form (R13) , and interacting this result with ( Thio semicarbazide)) and (sodium hydroxide 10%) for the preparation of R14)), which through its interaction with (chloro ethyl acetate) is the preparation of the compound (R15 The oxidizing the resulted compound by (acetic acid) and (hydrogen peroxide) , gives (R16). Part six : - includes preparing compound (R17) by interacting( 2 - mercapto benzoic acid)) with(3 - chloro propanoyl chloride) and interacting the finally with (Thio semicarbazide) give (R18), which we can obtain011compound (R19) by interacting with (chloro ethyl acetate).All the prepared compounds have been following up the interactions enabled chromatography thin layer (TLC) for each prepared vehicles and characterized by (IR) spectrum NMR proton (1H.NMR), and a nice nuclear magnetic resonance of carbon (13C.NMR) and (C.H.N), and then measure the degree of fusion.Section II : This section includes the study of the biological inhibitory action to some of the prepared compounds on positive bacteria for dye Gram (Staphylococcus aureuse) and another negative bacteria for dye Gram (Escherichia Coli). All the compounds showed effect against both selected bacteria in the study.The Scheme below clarifies

تحضير مركبات الكبريت غير متجانسة الحلقة ودراسة الفعالية الحيوية لبعض منها == Synthesis Sulfur Heterocyclic Compounds and Study Biological Activity for Some its

Author name: انتصار عبيد سلمان الفتلاوي

Supervisor name: نغم محمود جواد الجمالي

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Najaf

First pages:

Abstract: The compounds of heterocyclic that have the qualities of a great biological and pharmacological importance, where we see through the growing literature in Chemistry published research in this area significantly, so we decided to prepare new derivatives of them.In this study prepared (16) a new deriva????ve of sulfur heterocyclic compounds such as Thiazole, Thiadiazole Thiazine, Thiadiazine, Thiazepine and Thiadiazepine, and three other intermediate compounds to prepare Some of these derivatives, these compounds ((Five, Six and Seven - Membered Heterocycles))The research included two Section of study : The first section : included prepara????on (19) compounds (I1 - I19), by four parts : The first part : included preparation (I1) of benzil interaction with thiosemicarbazide and then the interaction of output with nitrous acid record spontaneously from mixing hydrochloric acid with sodium nitrite, to form a diazonium salt and then reactance this salt with (Acetyl acetone) to prepare azo compound (I2), and Then reactance output with thiourea, thiosemicarbazide, Thioacetamide and cysteine respectively for the preparation of compounds (I3 - I6).The second part : included reactance (diethyl terephthalate) with thiosemicarbazide, cysteine to prepare the compound (I7) and compound (I9), respectively, and then reactance outputs with Sulfobenzoic anhydride, thiosemicarbazide respectively to produce the compound (I8) and compound (I10), respectively. The third part : included reactance (1,3 - diphenylpropane - 1,3 - dione) with thiosemicarbazide to give the compound (I11) and then output reactance with benzaldehyde to give the compound (I12) and then output with reactance Sulfobenzoic anhydride to give the compound (I13). The fourth part : includes reactance (p - amino acetophenon)with nitrous acid record spontaneously from mixing hydrochloric acid with sodium nitrite, to form a salt of diazonium and then reactance this salt with diethyl mal Acetyl acetone to give compound (I14) and compound (I17), respectively, and then reactance thiosemicarbazide, benzaldehyde respectively, to give the compound (I15) and compound (I18), respectively, and then outputs reactance with Sulfobenzoic anhydride, thiourea to give compound (I16) and compound (I19), respectively. All interactions followed up by thin layer chromatography (TLC) for each prepared compounds and diagnosed by spectrum infrared (FT.IR) spectrum, proton nuclear magnetic resonance (1H.NMR), nuclear magnetic resonance of carbon (13C.NMR) and Elemental Analysis(C.H.N), and then measure the melting point. The second section : This section of the research included the study of the inhibitory action of the some of biological compounds against the gram - positive bacteria (Staphylococcus aureuse) and gram - negative bacteria (Escherichia coli) and all showed the effectiveness of the compounds against selected bacteria in the study type.

دراسة مركبات الاوزميوم العنقودية باستخدام كيمياء الكم == Quantum Chemical Studies of Osmium Clusters

Author name: احلام حسين حسن

Supervisor name: محسن عبود محسن العبادي

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - Faculty Of Education - Chemistry Department

Language: English

University location: Najaf

First pages:

Abstract: تضمنت هذه الدراسة تحضير عدد من المشتقات الجديدة للدايهيدروبريميدينون والكوينزولينون وذلك من خلال عدة مسارات. المسار الاول تم تحضيرالمركبان (86,85) بعملية البنزلةbenzylation) ) والسلفنةsulfonation) ) لمشتق الالديهايد(4 - هيدروكسي بنزلديهايد) لانتاج الديه | The studies involves synthesis some new derivatives for the ( 3 , 4 dihydropyrimidin - 2(1H) - ones) by many schemes. The first Scheme involve synthesis compounds (85,86) by Benzylation and Sulfonation for aldahyde derived (4 - Hydroxybanzaldahyde) to give aldahydes larger and treatment in Biginelli reaction. The second Scheme includes preparation of derivatives(87 - 99) by Biginelli reaction for treatment different derivatives aldahydes with Ethylacetoacetate or Acetylacetone and Urea Catalyzed by Hydrochloric acid to give ( 3 , 4 dihydropyrimidin - 2(1H) - ones) The third Scheme includes preparation of Quinazolinone compounds (100 - 105) via reaction Cyclohxanone , Aldahyde derivativesand Urea Catalyzed by tributylborate in methanol as solvent. The last Scheme is treatment compound(90) is contan ketone group and a product via Biginelli reaction with primary amines such as p - toluidine and phenylhydrazine to give new Schiff base , also treatment compound(90) with diffrents aldehyde to give of pyrimidine compounds it is contan of Chalcones. As well as the thesis which us discussed the preparation and identification of newdihydro pyrimidine derivatives from throough spectra (I.R) , (1H - NMR) , (C13 - NMR) , (C.H.N) , specta (HSQC) , (COSY) and (HMBC). For some of these compounds, and these identification studies approved the correctness of the chemical structures for the prepared derivatives The study of biological activity of some of the synthesized compounds which were applied on bacteria of negative and positive gram formula showed that some of the studied compounds possess medium retardation activity against these bacteria.

تحضير وتشخيص مشتقات 3,1 - اوكسازيبين جديدة ودراسة الفعالية الحيوية لبعض هذه المركبات == Synthesis And Characterization Of New 1,3 - Oxazepine Derivatives And Study Of The Biological Activity Of Some Of These Compounds

Author name: زينب عامر صلال الشكري

Supervisor name: حسن ثامر غانم

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: University of Kufa - College Of Science - Chemistry Department

Language: English

University location: Najaf

First pages:

Abstract: تم من خلال هذا العمل تحضير مشتقات 3،1 - اوكسازيبين جديدة تحتوي في تركيبها على مجموعة الازو. الخطوة الاولى تتضمن تحول (4 - ميثوكسي انلين) الى 4 - (داي مثيل امينو) - 3 - ((4 - ميثوكسي فنيل)) داي ازو) بنزلديهايد [Z] عن طريق تفاعل الازدواج مع (4 - N,N - داي مثل امينو بنزلديهايد). الخطوة الثانية تتضمن ادخال مجموعة الديهايد مشتق الازو المحضر[Z] في تفاعل تكاثف مع امينات اولية اورماتية مختلفة (4 - ميثوكسي انلين و4 - هيدروكسي انلين و4 - كلورو انلين و4 - امينو اسيتوفينون و2 - امينو بيرمدين و4 - امينو - N - (بيرمدين - 2 - ايل)بنزين سلفونامايد) بوجود الايثانول المطلق فتم الحصول على مشتقات ازو قواعد شف الجديدة [A6 - A1] على التوالي .اما الخطوة الثالثة فتتضمن مفاعلة مشتقات الايمين الناتجة [A6 - A1]مع كل من انهدريد المالك وانهدريد الفثاليك في البنزين الجاف فتم الحصول على مشتقات حلقية جديدة 3,1 - اوكسازيبين - 7,4 - دايون[A12 - A7] و[A18 - A13] على التوالي وان المخطط [ I ] يوضح خطوات تحضير كافة المركبات. ان جميع المركبات المحضرة شخصت بوساطة درجات الانصهار ومطيافية الاشعة تحت الحمراء والبعض منها شخصت بوساطة مطيافية الرنين النووي المغناطيسي البروتوني وتحليل العناصر الدقيق (كاربون, هيدروجين, نيتروجين). الخطوة الاخيرة تتضمن دراسة الفعالية البايلوجية لبعض المركبات المحضرة ضد نوعين من البكتريا هما : 1 - Staphylococcus aureus (Gram positive).2 - Pseudomonas aeruginosa (Gram negative).وضد نوعين من الفطريات هما : 1 - Aspergillus niger.2 - Penicillium. بعض المركبات كانت تمتلك فعالية تثبيطية عالية ضد البكتريا ولكن بعض المركبات كانت غير فعالة بينما نتائج الفعالية ضد الفطريات اوضحت بان كل المركبات كانت تمتلك فعالية جيدة ضد الفطريات المستخدمة. | In this work new 1,3 - oxazepine derivatives containing azo group have been prepared. The first step, 4 - methoxyaniline was converted to the 4 - (dimethylamino) - 3 - [(4 - methoxy phenyl)diazenyl]benzaldehyde [Z] by coupling reaction with 4 - N,N - dimethlaminobenaldehyde. The second step, aldehyde group of the azo derivative [Z] was condensed with different aromatic primary amines [4 - methoxyaniline, 4 - hedroxyaniline, 4 - chloroaniline, 4 - aminoaceto phenone, 2 - aminopyrimidin and 4 - amino - N - (pyrimidin - 2 - yl)benzenesulfonamide] in the presence of absolute ethanol to give new azo Schiff bases derivatives [A1 - A6] respectively. The third step, the resulting imines derivatives [A1 - A6] were reacted with maleic anhydride and phathalic anhydride in dry benzene to give new 1,3 - oxazepine - 4,7 - dione ring derivatives [A7 - A12] and [A13 - A18] respectively scheme[I]. All these compounds were characterized by melting points and FT.IR spectroscopy, some of them were characterized by 1H - NMR spectroscopy and C.H.N analysis. The last step including study biological activity of some prepared compounds against two types of bacteria : 1. Staphylococcus aureus (Gram positive). 2. Pseudomonas aeruginosa (Gram negative).and against two types of fungi : 1. Aspergillus niger.2. Penicillium. Some compounds showed high inhibition activity against bacteria but other compounds were inactive against same bacteria while the antifungal activity data showed that all compounds exhibited good activity against fungus species.