البحث — المستودع الرقمي العراقي

نتائج البحث: 7 من أصل 7

التشوهات الخلقية في اجنة الفئران السويسرية البيضاء من امهات معاملة بجرع مختلفة من عقار Mus masculus الديكساميثازون Developmental anomalies in swiss albino mice embryos Mus masculus from the mother treated with different doses of Dexamethasone

اسم المؤلف: صدى غالب طاهر الموسوي

اسم المشرف: علي نعيم سلمان

الموضوع العام: علوم الحياة

السنة: 2016

الموضوع الدقيق: الحيوان - الاجنة

الدرجة: ماجستير

الجامعة: جامعة ذي قار - كلية التربية للعلوم الصرفة

اللغة: الانكليزية

مكان الجامعة: ذي قار

الصفحات الاولى:

المستخلص: The current study was conducted for the period from September 2015 until August 2016 in college of Education for Pure Sciences - University of Thi - Qar, this study aimed to fallow the embryonic lung development and evaluate histological changes in embryos's lung development when pregnant mice treated with different doses of Dexamethasone (Dex) and evaluate Alpha - fetoprotein (AFP) levels were evaluated as an indicator for congenital malformations. Sixty pregnant mice were randomly divided into four groups and each group contain 15 pregnant mice. The members of each group were given specific dose of Dex and at different time periods, while the control group injected with a solution of Normal Saline 0.9%.All animals received doses used by tail intravenous injection until the end of the time periods specified .Blood samples were taken for the purposes of biochemical parameters account as well as the collection of samples for histological study .The treatment of animals under the same conditions were determined with a dose based on body weight, according to what was stated in the pharmaceutical constitutions where's the therapeutic dosage was 0.002 mg \2mg (0.1mg.kg from body weight ). We used another two concentrations from drug ,one less than the therapeutic dosage (0.05mg \kg from body weight) and another more than the therapeutic dosage (0.2mg \kg from body weight ).The results have showed that was a negative effects on mice embryo's body weights and the lengths increase with increasing of number and doses concentrations. The using of different doses of Dex also showed various changes in general external morphological features and congenital malformation in embryos of treated mothers included : Death of embryos ,placenta damage ,neural Tube Defect ,Trunk Torsion ,Headhemorrhage, Brain hypertrophy ,Liver Hypertrophy ,Letter C Shape Embryos, swelling ,Convoluted Tail ,Short nostril and limbs, curved head, Wrinkled skin ,Crooked pave ,Short toes ,Seal legs appearance, Oedema ,absent fingers and eyelids ,Tail congestion and Bulging eyes. Histologically microscopic examination showed histological changes with varied severity and appearing between different sub experimental group compared with the control group.Rapid elongation in lung bud, advancing in lung development, the lung asflower appearance, Loosely lung mesenchyme ,necrosis in lung tissue ,mucus hypersecretion, elongation in epithelial air ways,epithelial Hyperplasia ,mesenchyme looks as butterfly in appearance in some parts ,thinning of alveolar walls ,thinning of the interstitialmesenchymal lung tissue ,elongation of developing alveolar septa ,free alveolar septa. Alfa - fetoprotein (AFP) levels showed different concentrations value in correlation with congenital malformations .when the (AFP) value was high there were neural tube defects and advancing in the lung development while they were low in normal lung development and in brain hypertrophy.

دراسة مقارنة بين تاثير سترات الكلوميفين وسترات التاموكسيفين على بعض معايير نطف الفئران Comparative Study On The Effects of Clomiphene Citrate And Tamoxiphene Citrate On Some Sperm Parameters In Mice

اسم المؤلف: رائد عبد الاله عباس

اسم المشرف: محمد باقر محمد رشاد فخر الدين محمد عوده سلمان

الموضوع العام: علوم الحياة

السنة: 2014

الموضوع الدقيق: الحيوان - الاجنة

الدرجة: ماجستير

الجامعة: جامعة النهرين - المعهد العالي لتشخيص العقم والتقنيات المساعدة على الانجاب

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى:

المستخلص: يعد العقم واحدة من المشاكل الاجتماعية المهمة في معظم انحاء العالم.استنادا الى الاحصائيات الحالية حوالي 15% من المتزوجين يواجهون العقم. يؤدي تقييم السائل المنوي غير الطبيعي للاستروجينات الى تشخيص قلة اعداد النطف ونشاطها وشكلها الطبيعي ومن ناحية اخرى تؤثر | Infertility is one of the most critical social problems in the all of population world. According to the current statistics, about 15% of married couples face with infertility. Assessment of abnormal semen parameters leads to diagnosis of oligoasthenoteratozoospermia, and in others, it leads to isolated abnormalities of sperm concentration, motility, and morphology, due to the lack of differentiable or correctable etiology, Both clomiphene citrate and tamoxiphene citrate, as an anti - estrogen, is the most common prescribed medication for male infertility. In humans, ant estrogens interfere with the normal negative feedback of sex steroids at the hypothalamus and pituitary, thereby increasing endogenous gonadotropin releasing hormone (GnRH) secretion from the hypothalamus and follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion directly from the pituitary. Objective : The objective of this study was to investigate the effect of clomiphene citrate (CC) and tamoxiphene citrate (TC) administered to male mice on quality of sperm parameters.Materials and Methods : Ninety six male mice were divided into two major groups, and every one of these groups was subdivided into three minor groups involving control and two treated groups. In the CC study, 48 mice were administrated orally 0, 0.0125 mg and 0.025 mg as control (G 1), low dose (G 2) and high dose (G 3) for 42 days. While, in the TC study, 48 mice were administrated orally 0, 0.01 mg and 0.02 mg as control (G 1), low dose (G 2) and high dose (G 3) for 42 days. Then, the male mice were sacrificed, both vas deferens were collected and assessment sperm parameters involving sperm concentration, sperm motility and activity, and normal sperm morphology. Results : The results of present study appeared that the use high dose of CC or TC significantly increment (P<0.05) sperm concentration as compared to control groups. However, use high dose of CC significantly increment (P<0.05) percentages of sperm motility and normal sperm morphology. Meanwhile, the percentage of progressive sperm motility was increased significantly (P< 0.05) when low CC dose administered as compared to control and high CC dose groups. In this study, percentages of sperm motility, progressive sperm motility and normal sperm morphology showed best elevation when used low TC dose as compared to both control and high TC dose groups. High TC dose causes significant increment (P<0.05) in the percentage of sperm agglutination when compared to control and low TC dose groups.Conclusions : Based on the results of this study, it can be concluded that the administration of high dose of either CC or TC increases sperm concentration, while administration of low dose of either CC or TC enhances progressive sperm motility.

تاثير الادينوسين ثلاثي الفوسفات على اخصاب وتطور الاجنة الاولي خارج الجسم الحي في الفئران كنموذج للجنس البشري Effect of Adenosine Triphosphate On In Vitro Fertilization And Early Embryonic Development In Mice As A Model For Human Being

اسم المؤلف: مهند علي مشكور

اسم المشرف: محمد باقر محمد رشاد فخر الدين نوال خيري العاني

الموضوع العام: علوم الحياة

السنة: 2014

الموضوع الدقيق: الحيوان - الاجنة

الدرجة: ماجستير

الجامعة: جامعة النهرين - المعهد العالي لتشخيص العقم والتقنيات المساعدة على الانجاب

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى:

المستخلص: يعد الاخصاب خارج الجسم الحي (IVF) من احد اهم التقنيات المستخدمة لانتاج اعداد كبيرة من الاجنة لبحوث التطور الاساسيه والبيولوجيا الجزيئية لنضوج البويضات المختبري والاخصاب. يعتمد الاخصاب خارج الجسم الحي وظروف حفظ الجنين المثلى على مكونات الوسط الزرعي كونها ا | In vitro fertilization (IVF) is one of the most important techniques used to produce large numbers of embryos for research into the basic development and molecular biology of in vitro oocytes maturation and fertilization. Optimal IVF and embryo culture conditions depend on the composition of culture media being the most important determinants of success in vitro interaction of the gametes and subsequent embryo development. Adenosine 5 - triphosphate (ATP) is a fundamental factor to maintain life, by providing energy, and controlling the cell function and metabolism. Objectives : The present study aims to investigate the effect of ATP supplied to SMART medium on a rate of fertilization and early embryonic development (ED) in mice as a model for human beings.Materials and Methods : The female mice (90) were superovulated using superovulation program to produce a large number of oocytes. These were divided into three groups, the first group was inseminated with vassal sperm in vitro alone (control); the seconed group (G2) was inseminated with vassal sperm in vitro using SMART medium enriched with low concentration of ATP(1.25mM). The third group (G3) was inseminated with vassal sperm in vitro using SMART medium enriched with high concentration of ATP (2.5mM). Mouse spermatozoa were collected from both vasdeferens. Then sperm parameters were assessed after 30 min. IVF technique was performed for 3 groups, and assessed after 20 - 22h. Then, percentages of early embryonic development stages and abnormal embryos morphology (%) for each embryo stage were assessed.Results : Results of the present study revealed significant increment (P<0.05) in the in - vitro fertilization (%) when using 1.25mM ATP as compared to 2.5 mM ATP and the control group. Significant differences (P<0.05) in the 1 - cell stage were assessed in 2.5mM compared with 1.25mM groups and the control group. Also, Significant differences (P<0.05) in the 2 - cell and 4 - cell stage were assessed in 1.25mM ATP compared with other groups. However, non significant differences in the percentages of abnormal embryos morphology were reported between both treated groups of ATP.Conclusion : From the results of present study it was concluded that the low ATP concentration (1.25mM) enriched to the culture medium improved the percentage of in vitro fertilization and early embryonic development.

نوعية البويضة والتكوين الجنيني بعد الاعطاء الفموي للسبيرماكس لاناث الفئران : موديل تجريبي للبائن Oocyte Quality And Embryonic Development After Oral Administration of Speramax® In Female Mice : Experimental Model For Mammal

اسم المؤلف: هبة صاحب حمزة

اسم المشرف: سعد صالح الدجيلي

الموضوع العام: علوم الحياة

السنة: 2014

الموضوع الدقيق: الحيوان - الاجنة

الدرجة: ماجستير

الجامعة: جامعة النهرين - المعهد العالي لتشخيص العقم والتقنيات المساعدة على الانجاب

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى:

تاثير ميثوتركسيت على كبد اجنة الفئران البيض Effect Of Methotrexate On The Liver Of Albino Mice Embryo

اسم المؤلف: زينب عبد السلام كاظم

اسم المشرف: هدى مهدي الخطيب عبد حسن براج

الموضوع العام: علوم الحياة

السنة: 2014

الموضوع الدقيق: الحيوان - الاجنة

الدرجة: ماجستير

الجامعة: جامعة بغداد

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى:

التاثيرات المشوهه لعقار البريكابالين في تطور المخيخ في اجنة الجرذان البيض The Teratogenic Effects Of Pregabalin Drug On The Cerebellar Development Of Albino Rat Embryos

اسم المؤلف: لينا عبد المطلب صالح

اسم المشرف: فريال عبد المناف المهداوي انعم رشيد الصالحي

الموضوع العام: علوم الحياة

السنة: 2013

الموضوع الدقيق: الحيوان - الاجنة

الدرجة: دكتوراه

الجامعة: جامعة بغداد

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى:

تاثير الكابابنتين بجرع مختلفة قبل وبعد الولادة على نسيج الكبد للفئران الحوامل والاجنة Prenatal And Postnatal Gabapentin Effect In Different Doses On Liver Tissue Of Pregnant Mice And Embryos

اسم المؤلف: صالح عبد الله حسين

اسم المشرف: فريال عبد المناف المهداوي نهلة عبد الرضا البكري

الموضوع العام: علوم الحياة

السنة: 2011

الموضوع الدقيق: الحيوان - الاجنة

الدرجة: ماجستير

الجامعة: جامعة بغداد

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى: