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Electron Microscopic Studies On The Effects Of Edtaantimiotic Enzyme On The Cell Envelope Of Resistant Strains Of Pseudomonas Aeruginosa

Author name: elham a . alaswad
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Epidemiology Of Cancer In Iraq 1981 1985

Author name: emmanuel t . taktak
Supervisor name: sabah al - obaidi
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Microelectode Study Of The Neuromuscular Subthreshold Acivity In Experimental Lead Poisoning

Author name: ali a . ahmed
Supervisor name: sahib j. mossawy | hadi khlili
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Repeated Stimulation Of The Motor Nerve And The Neuromuscular Fatigue

Author name: nauras k . a . baban
Supervisor name: sahib v. mossawy
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Investigations Of Tone And Rhythmicity Of Mammalian Smooth Muscle

Author name: muhammad a . m . al gailani
Supervisor name: suhib mossa
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

سرطان القولون في العراق : دراسة وبائية == Carcinoma of The Colon in Iraq : Epidemiological Study

Author name: علي موسى مهدي
Supervisor name: E. N. Kassira
General topic: Medicine
Specific topic: Community Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Seroepidemiological Study On Cytomegalovirus

Author name: emad ahmed abdul - kaarem
Supervisor name: tariq s. al - hadithi | sanad m.a. al - balaghi
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Evaluation Of Biochemical Tumor Markers In Monitoring Ovarian Cancer

Author name: sawsan abdl azia abu regaiba
Supervisor name: muayad mehdi abboud
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

The Effect Oh Some Broad Spectrum Anthelmintics On The Larval Stage Of Echinococcus Granulosus In Experimental Animals

Author name: ghazi rajab audaal - hadrawi
Supervisor name: kassin
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Isolation And Identifiction Of Pathogenic Bacteria Encountered In Cases Of Wound Infection With Their Antibiobiogram Pattern

Author name: haifa abdulkader maki
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Psychoneurotic Profiles Students

Author name: abdullah s . abdullah
Supervisor name: basil alchalabi
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

استقصاءات كهروفيزياوية عن الرجفة Tremor عند مرضى انسمام الغدة الدرقية Thyrotoxic patients فرط افراز الغدة الدرقية == Electro physiological Investigation of Tremor in Thyrotoxic patients

Author name: Fakher S. Al-Ani
Supervisor name: Sahib J. Mossawy | Thabit N. Al-Hiti
General topic: Medicine
Specific topic: Physiology
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Variations In The Epidemilogal Pattern Of Trachoma In Iraq Within Ten Years

Author name: shamran hammood hashim
Supervisor name: mohammed j.al - khashali
General topic: Medicine
Specific topic: Medicine
Degree: Higher Diploma
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

وبائية العرق العقلي في العراق خلال خمس سنوات == Epidemiology of Mental handicap in Iraq With in Five Years

Author name: ثائر عبد الواحد محمد
Supervisor name: S. Al-Obiadi
General topic: Medicine
Specific topic: Community Medicine
Degree: Higher Diploma
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Response Of Obese Hypertnsive Patients To Diet And Drug Therapy

Author name: IHSAN J . SALEH
Supervisor name: mohammed j.al - khashali
General topic: Medicine
Specific topic: Medicine
Degree: Higher Diploma
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Morbidity Rates Of Skin Diseaes In Baghdad City

Author name: hassan musleim abdul - hussein
Supervisor name: a.w. al - mufti
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
Key words:
  • Skin - Deseases - Baghdad%Thesis

طرق بديلة لتجميد خلايا الدم الجذعية المولدة للدم للانسان المستعملة للزرع == alternative methods of cryopreserton of human peripheral blooestem cells for tranplantaion

Author name: نضال كريم معروف الرحال
Supervisor name: زيد عبد المجيد المدفعي | عبد المجيد علوان حمادي
General topic: Medicine
Specific topic: Physiology
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

Admissions To Fever Hospital In Baghdad During 1985

Author name: kahian Kahtan jasim
Supervisor name: gheib m . mukhlis
General topic: Medicine
Specific topic: Medicine
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
Key words:
  • epidemiology.; diseases.; thesis.;

نسبة الاصابة بالربو القصبي عند موظفي قسم المنظفات في الشركة العامة للزيوت النباتية بغداد == the provalonee of bronehial asthma among detdgont omployoos of the vegetable oil company baghdad

Author name: انوار عبد الله حسن
Supervisor name: Walid G. AL-Tawil
General topic: Medicine
Specific topic: Medicine
Degree: Higher Diploma
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad

مرض الالتهاب المعدة والامعاء المتعدد العوامل في الاطفال الرضع == Infantile Gastroenteritis Multifactorial Disease

Author name: هدى صاحب عبد المحمد الروازق
Supervisor name: محمد عبد الاخوة حسن الفحام
General topic: Medicine
Specific topic: Microbiology
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: Total no. of patient (100) stool samples were collected, during the period from February to the end of May of 2008, for children under two years old suffering from non-bloody and bloody diarrhea at (Children Welfare Teaching Hospital) in Baghdad.
The study evaluates the relationship between etiological agent of diarrhea and sex, age group, type of feeding, presence of blood in stool of the patients. All samples were examined microscopically to identify parasitic agent and serological test for Rotavirus to identify viral infection, also biochemical and serological tested for specimen's culture on different culture media and antibiotic sensitivity test.
Results show from 100 cases 64] represents the etiological agent of diarrhea and the most common of this agent was Rotavirus represent (37.5 %), respectively then Entamoeba histolytica (21.9 %), other agents were include Proteus (12.5 %), Enteropathogenic E.coli (10.9 %), Citrobacter braakii (7.8 %), Salmonella typhi (6.3 %), and Giardia lamblia (3.1 %). The remaining 36 isolates represent of unknown etiological agent for another's pathogen.
The prevalence ratio of infection in male (75.0 %) was more than in female (25.0 %), in the first year of age especially in the age group (0-6) months (42.2 %). children depending on artificial feeding represent about (57.8 %) higher natural and mixed feeding, the bloody diarrhea associated with Entamoeba histolytica (57.1 %) in contrast to some etiological agent of non-bloody diarrhea.
Eleven types of antibiotics were used for sensitivity test show all serotype of Enteropathogenic E.coli and Salmonella typhi are sensitive to Imipenem and Ciprofloxacin. The predominant serotypes of Enteropathogenic E.coli which represent serotype O111 and serotype O125 these strains show resistance to Cefotaxime (CTX), Trimethoprim-sulfamethaxazole (SXT), Ampicillin (AM), Metronidazole (MET), Cefoperazone (CEP), Cefixime (CFM), also the serotype O111 resistance to Gentamicin (CN) represent (45.0 %), while the most resistance of Salmonella was to Amikacin (100.0 %).
This may reflect the fact that the increased resistance in older children and adult may be associated with the development of immunity or the loss of receptors for some specific adhesion.
In Iraq Rotavirus infection is estimated to account for (10-29 %) in early childhood, While in neighboring countries the rate ranges between (19-46 %). The study show infected males more than female and the highest diarrheal infection was caused by Rotavirus, the Imipenem and Ciprofloxacin antibiotic was the most effective one against pathogenic strains of Enteropathogenic E.coli and Salmonella typhi while all isolates were resistant to Trimethoprim-Sulfamethaxazole, Ampicillin, Metronidazole.
Summary:
References:

دراسة الدهون الاسفنجية النشطة بايولوجيا والانزيمات الاستقلابية في كل من تضخم البروستات الحميد وسرطان البروستات الخبيث == Bioactive Sphingolipids and metabolizing enzymes in patients with benign prostate hyperplasia and malignant prostate cancer

Author name: رغدة عبد المنعم رزوقي
Supervisor name: رائد جاسم محمد التميمي | اسامة سليمان قدوري الناصري
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: Bioactive Sphingolipids an important molecules of structural and signaling lipids. In this study was highlight on new biomarkers uses to investigate prostate cancer by using new method HPLC fluorescence detector to measure concentration and activity enzymes sphingosine - 1 - phosphate lyase enzyme (SPL) and Acid Ceramidase enzyme (AC) by used new material (BODIPY) aromatic structural is binding with enzymes and give fluorophore product sensitive by HPLC fluorescence detector in patients have BPH and PC in serum and tissue and comparing with healthy men as (control). Eliza method was used to measured sphingosine - 1 - phosphate and Ceramide in patients (BPH and PC) in serum and tissue with controls in serum. Sphingolipids metabolites pathological processes, are established regulators of myriad cellular and sphingolipids research is intricate due to the role of these molecules in vastly different biologics, interconnected metabolic pathways and structural properties. Ceramide and sphingosine - 1 - phosphate (S1P), SGPL and AC have been defined as reciprocal regulators of cellular fate, and not surprisingly have been targeted for their role in cancer and their therapeutic potential, sphingolipid metabolic enzymes and lipids are metabolically interconnected and highlight recent findings to support the reciprocal role of Ceramide and S1P in cellular processes and in cancer. Studies show increase levels markers in serum and tissue in BPH and PC with healthy men and different Km and V max in AC and SPL between healthy, BPH and PC patients also this reaction was noncompetitive inhibition with enzyme because V max was change and Km was not change in all cases these results were accepted with studies in America and Spain (Liu, Y.Y.; Patwardhan, G.A.;et al. 2011).IXAim of study1 - 1 - The main aim of this study is found a new sensitive and specific bio markers for diagnosis prostatic cancer And other goals of conducting this study are : 2 - To measure activity of Acid ceramidase and Sphingosine - 1 - Phospate Lyase in sera and prostate tissue of patients with benign prostatic hyperplasia and prostate cancer and compare these activities of enzymes with normal controls.3 - To determine the concentration of bioactive Sphingolipids Ceramide and Sphingosine - 1 - phosphate in tissues and sera of the patients and control.4 - To correlate the level of bioactive lipids with serum PSA concentration to detect their use as additional biomarker for diagnosis and follow up of patient with prostate cancer.Methods : A case - control study design was employed in this study. On a total of 30 patients with confirmed PC, 30 patients with BPH and age matched 30 healthy men. Prostate tissue samples were obtained for patients were serum and urine samples were collected for patients and controls. Enzyme linked immune assay (Elisa) was used to measure S1P and Ceramide concentration in serum and tissue, while HPLC fluorescence detector was used to estimate activities of SPL and AC and measured Km and V max. Urine and serum samples were undergone biochemistry analysis. HbA1c was used to measure cumulative sugar for three groups. Protein in tissue was measure by brad ford method to PC and BPH patients.Results : The results showed that increase levels of Sphingosine 1 phosphate lyase and Acid ceramidase in serum and tissue in BPH and Malignant cancer in men these levels were different result in patient wereXtaken drugs or not and patients were taken chemotherapy or not and activity, Km and Vmax of enzyme SPL and AC were different in BPH and PC that men is inhibition enzymes was noncompetitive it had same Km but different data of control, BPH and PC men in tissue and serum.The concentration of S1P and Ceramide were different levels with control, and high levels in patients without any drugs or chemotherapy while levels of these markers still low with patients were taken drugs or chemotherapy and level of protein in tissue were raised. Results of biochemistry analysis still normal because we take patients without any D.M., renal failure, and hypertension.

تقييم الانزيمات المعدنية المحللة للبروتين - 9 MMP - 9 والانترلوكين - 18 (IL - 18) في دم الحبل السري والنسج البيني في الولادات القيصرية والمهبلية الطبيعية == Matrix Metalloproteinase - 9 and IL - 18 Level in Cord Blood and Tissue Matrix in Caesarean and Normal Vaginal Delivery

Author name: خوله عبد الحمزة شمران مشجل
Supervisor name: ريا سليمان صلاح الدين بابان | مي فاضل ماجد الحبيب
General topic: Medicine
Specific topic: Clinical Biochemistry
Degree: Doctorate
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: ماتركس ميتالوبروتياز Matrix metalloproteinases اختصارا (MMPs) وهي انزيمات تعتمد على الزنك وتحتوي على اندوبيبتيداز endopeptidases . هذه الانزيمات لها القدرة على احداث التحلل في جميع انواع البروتينات للمصفوفة خارج الخلية، ولكن ايضا يمكن معالجة عدد من الجزيئات النشطة بيولوجيا. ومن المعروفة انها تقوم بالمشاركة في انشقاق والانقسام لمستقبلات سطح الخلية، واطلاق المعقدات المسؤولة عن موت الخلية (مثل معقد FAS)، وعدم تفعيل السيتوكينات cytokines. وايضا خلال فترة الحمل تحدث تغيرات فسيولوجية خاصة مثل نضج عنق الرحم، وتمزق الاغشية الجنينية، وانفصال المشيمة والذي تتطلب اعادة تشكيل المصفوفة خارج الخلية (ECM) . السيتوكين مثل الانترلوكين (IL - 18)يلعب دورا حاسما في دفاع المضيف، وانها قد تكون جزء في توفير حاجز لعنق الرحم/ ساقطي ضد الغزو الميكروبي من السائل الذي يحيط بالجنين وقد يكون بمثابة علامة لعنق الرحم للعدوى داخل الامنيوتك Amniotic. الاجهاد التاكسدي، وهي حاله تتميز بعدم التوازن بين الجزيئات المؤكسدة، بما في ذلك الانواع الاكسجين التفاعلية (ROS)، وبين دفاع المضادات للاكسدة Antioxidant . هذه ROS قد يسبب اصابات الانسجة مما يؤدي الى تلف البروتينات الخلوية داخل الخلايا ، والحمض النووي DNA التي تورطت في مضاعفات الحمل في بوقت مبكر اثناء المخاض، ويمكن ان يؤثر على طريقة الولادة . استجابة الجسم المناعية تتضمن المضادات للاكسدة الانزيمية وغير الانزيمية التي تقلل من تاثير هذه الجذور الحرة. تهدف هذه الدراسة الى تقييم العلاقة بين مستويات انزيم ماتركس ميتالوبروتياز - 9 (MMP - 9 )ووضعية الحمل. الطرق : في هذه الدراسة تم تعيين ستة واربعين النساء الحوامل (31 حاملا خضعن للولادة الطبيعية، 33 حاملا خضعن للولادة القيصرية. . تم جمع نموذج الدراسة من صالات النسائية والتوليد في مدينة الامامين الكاظمين الطبية خلال فترة من حزيران من 2015 الى تموز من 2016.واخذت موافقة النساء الحوامل قبل الدخول لصالة العمليات, وتم اخذ عينات من الدم وقطعة من النسيج جمعت خلال خمس دقائق من الحبل السري. تم جمع عينات الانسجة الحبل السري ايضا اثناء الولادة. واستخدمت عينات دم وانسجة لقياس الفلزي المصفوفة (MMP - 9)، وانترلوكين 18 (IL - 18)، وايضا تم استخدام نماذج الدم لقياس معدل جهد التاكسد في مصل الدم والمضادات للاكسدة (SOD) والعناصر النزرة. النتائج : اظهرت النتائج ان تدهور في المستويات الحيوية ل( MMP - 9و IL - 18) في الدم النساء اللواتي خضعن الولادة الطبيعية. وكانت عالية في النساء اللواتي خضعن للعملية القيصرية وبالاضافة الى ذلك، فان مستويات الانزيمات المضادة للاكسدة الاقل بين النساء اللواتي خضعن للولادة الطبيعية واعلى بين النساء اللواتي خضعن للعمليات القيصرية. وذكرت في الدراسة ايضا انخفاض كبير في مستوى العناصر النزرة المؤشرات الحيوية (الزنك والنحاس والمغنيسيوم) في الدم النساء اللواتي خضعن للعملية القيصرية مقارنة مع مجموعة النساء اللواتي خضعن الولادة الطبيعية. الفحص النسيجي للنسيج الحبل السري من النساء الحوامل كشفه عن نتائج مطابقة لنتائج فحوصات الدم حيث بينت عن ارتفاع معنوي في تركيز انزيم MMP - 9 والانترلوكين IL - 18 في النساء اللواتي خضعن للعملية القيصرية مقارنة مع مجموعة النساء اللواتي خضعن الولادة الطبيعية.الاستنتاجات : ارتبط الولادة الطبيعية مع زيادة الاكسدة وانخفاض في النشاط المضادة للاكسدة وفي المقابل انخفاض الاجهاد التاكسدي وزيادة في النشاط الانزيمي المضادة للاكسدة (SOD) في الولادات القيصرية ،. واضاف لذلك ارتبط الولادة الطبيعية بانخفاض معنوي في مستويات انزيم MMP - 9 والسايتوكينات IL - 18 مقارنة مع مجموعة النساء اللواتي خضعن الولادة الطبيعية. ومن ناحه اخرى اظهر الفحص النسيجي هنالك تركيزات عالية MMP - 9 وIL - 18 في الانسجة الحبل السري للمراة التي تخضع للعملية القيصرية بالمقارنة مع النساء اللواتي الولادة الطبيعية. | Matrix metalloproteinases (MMPs) are calcium - dependent zinc - containing endopeptidases. These enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and cytokine inactivation. During pregnancy, specific physiological changes such as cervical ripening, rupture of the fetal membranes, and placental detachment require the remodeling of the extracellular matrix (ECM). Cytokine like Interleukin - 18(IL - 18) play a critical role in host defense, and it may participate in providing a cervical/decidual barrier against microbial invasion of the amniotic fluid and might serve as a cervical marker for intra - amniotic infection. Oxidative Stress, a state characterized by an imbalance between pro - oxidant molecules, including reactive oxygen species (ROS), with antioxidant defense. These ROS may cause tissue injury resulting in cytotoxic damage to cellular proteins, and DNA which has been implicated in early pregnancy complications and during ,labor and may effect on mode of labor. Body defense response involves enzymatic and non - enzymatic antioxidant buffering pathways which reduce the effect of these free radicals. This study aimed to assess the relationship between matrix metalloproteinase enzyme levels and delivery mode and also an attempt to assess the impact of oxidative stress on maternal antioxidant defense during labour and correlate it with mode of parturition. Methods : A case - control study design was employed in this study. Sixty four pregnant women were recruited 31 term pregnant women with normal vaginal delivery and 33 term pregnant women underwent cesarean section delivery. At the time of their admission to operation theatre, blood samples were taken and a piece of tissue was collected from umbilical cord after delivery . Blood and tissue samples were used to measure matrix metalloproteinase (MMP - 9), Interleukin - 18 (IL - 18), Superoxide Dismutase (SOD) activity and trace elements levels was determined in the umbilical cord blood only. Placental tissue was prepared and stained for histological assessment. Anti - MMP - 9 and Anti - IL - 18 monoclonal antibody laboratory kits were employed to demonstrate degradation and cytokine levels in umbilical cord tissue. Results : results showed that both blood MMP - 9 and IL - 18 levels were significantly higher in term women who underwent cesarean section compared with those women who underwent normal vaginal delivery. In addition, the enzymatic anti - oxidant SOD was significantly lowest among term women who underwent normal vaginal delivery when compared term women who underwent cesarean section. The present study also reported a significant decreases in level of trace elements (Zn, Cu and Mg) in blood of term women who underwent NVD compared those a with C/S labor (P<0.01). The histological examination of umbilical cord tissue revealed that term women underwent normal vaginal delivery group had the lowest reactivity with both anti - MMP - 9 and anti - IL - 18 monoclonal antibody in comparison to term women underwent cesarean section group. From the study it was concluded that term pregnancy women underwent normal vaginal delivery was associated with increased oxidative stress and decreased anti - oxidant activity. In contrast, term pregnancy underwent cesarean section was associated with low oxidative stress status and high enzymatic anti - oxidant activity (SOD). In other hand, pregnancy underwent with cesarean section was significantly associated with high levels of serum MMP - 9 and IL - 18 and high level of enzymatic anti - oxidant activity (SOD). While the Histological examination showed high MMP - 9 and IL - 18 concentrations in the umbilical cord tissue of term women underwent cesarean section in comparison to term women underwent normal vaginal delivery

دراسة كيميائية حياتية لارتباط المستضد بضاده الحيوي في مرضى داء CA19 - الكاربوهيدراتي 9 السكري من النوع الثاني باستخدام مقايسة الممتز المناعي المرتبط بالانزيم مع بعض التحويرات == Biochemical Studies of the Binding of CA 19 - 9 to its Antibody in Patients with type 2 Diabetes Mellitus using Enzyme - Linked Immunosorbent Assay with some Modifications

Author name: رسل رياض عباس
Supervisor name: حسن حسين طه السعيد | محمود شاكر خضير
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: Carbohydrate Antigen CA19 - 9 has been widely utilized for diagnosis of different kinds of cancer such as pancreatic cancer, cancer of upper gastrointestinal tract. It may also be used as an indicator of pancreatic tissue damage that may be caused by diabetes.The method of enzyme linked immunosorbent assay (ELISA) for measurement CA19 - 9 in sera of patients with type 2 diabetes mellitus was developed using external CA19 - 9 antibody (competitive sandwich ELISA technique) and found to be suitable for the determination of a dissociation constant (Kd) of the binding of CA19 - 9 to its antibody in type 2 diabetic patients using scatchard plot. Objectives : - This study was performed to assess CA19 - 9 levels in sera of patients with type 2 diabetes mellitus with non - cancerous tissue by enzyme - linked immunosorbent assays (ELISA) and define the normal range (cutoff value) for the same marker in this patients also investigated the possible relationships of CA19 - 9 with fasting plasma glucose and HbA1c.This study present a new method for determination the dissociation constant (Kd) of the binding of CA19 - 9 to its antibody in type 2 diabetic patients using scatchard plot through development of ELISA (competitive sandwich ELISA technique).Different factors affecting this binding were extensively studied such as divalent cations, different halides, and Polyethylene (PEG - 6000).

قيمة التتبع النقطي المقطع بالموجات فوق الصوتية لعضلة القلب للكشف عن مرض الشرايين التاجية مقابل تصوير الاوعية التاجية == Detection Of Coronary Artery Disease Using 2D - Regional (Segmental) Longitudinal strain (RLS) Comparing with Coronary Angiography in Patient with Acute Coronary Syndrome

Author name: عماد محمود حسين
Supervisor name: نزار ناصر عباس العتابي
General topic: Medicine
Specific topic: Echocardiography
Degree: Higher Diploma
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: Background : Speckle - tracking echocardiography is a new noninvasive ultrasound imaging technique that allows for evaluation of global and regional myocardial function.Aim of the Study : to evaluate the accuracy of regional(segmental) longitudinal strain by 2D - STE for pick up culprit vessels in ACS by detecting ischemic segments of the corresponding territories and its severity compared with coronary angiography as a gold standard, in patients with acute coronary syndrome .Patients and Methods : A cross sectional study was held in Baghdad teaching hospital from March 2017 to March 2018, consisted of patients with acute coronary syndrome(ACS) underwent 2D - STE for left ventricular regional longitudinal strain(RLS) immediately before invasive coronary angiography .Results : Fifty patients who fulfilled the inclusive criteria were enrolled in this study. The mean age 57.2 (± 7.9) years; and male : female ratio 1.9 : 1. Regional Longitudinal strain - speckle tracking showed 38 patients had CAD and 12 patients had no CAD, Versus coronary angiography which showed 29 patients had CAD while 21 patient had no CAD or non significant lesions.The validity of RLS according to coronary angiography showed sensitivity 100%, specificity 57.1% ,PPV 76.3%,NPV 100%, and accuracy 82%.Conclusion : The current study revealed that (RLS) Speckletracking echocardiography technique has high sensitivity but with relatively low specificity in diagnosis of coronary artery disease in patient with acute coronary syndrome.

صلاحية فحوصات الفسلجة العصبية بتنبؤ شدة متلاكمة غوليان باري وباستحقاق التنفس الاصطناعي == Validity of neurophysiological study in prediction of severity of Guillain - Barre syndrome and the indication for mechanical ventilation

Author name: بلال صادق عبد الباقي
Supervisor name: نجیب حسن محمد | زكي نوح حسن
General topic: Medicine
Specific topic: Neurophysiology
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: Guillain - Barre syndrome is an acute monophasic, non - febrile postinfectious illness manifesting as ascending weakness, and areflexia.However, sensory, autonomic and brainstem abnormalities may also seen. It is one of the most common causes of acute motor paralysis. In addition to the clinical presentation, those patients may develop neurophysiological features suggestive of demyelinating neuropathy.However, an axonal form had been reported. Hence, the importance of electrophysiological study; nerve conduction study (NCS) and electromyography (EMG) in the neurological evaluation of the severity of Guillain - Barre syndrome and the indication for mechanical ventilation.This study aimed to evaluate the neurophysiological study in prediction the severity of GBS, assess the usefulness of neurophysiology in prediction of respiratory muscles involvement and find out whether the neurophysiological study of peripheral nerves can predict the indications of mechanical ventilation.Two groups of patients are involved in this study. 22 Patients with GBS in the neuromedical wards and 18 patients in the respiratory care units (RCU).The mean age of the two groups were (47+\ - 24 years) with female predominance (1.22 : 1).Each patient submitted to brief medical history, clinical examination and neurophysiological study. This study was conducted at the neuromedical wards and RCU departments of Hospital of neurosciences, Baghdad and ALyarmuk teaching hospitals in a period from December 2017 to June 2018.The neurophysiological assessments involve the following tests : 1. Sensory NCS of bilateral median, ulnar and sural nerves involve sensory latency and sensory nerve action potential (SNAP). 2. Motor NCS of bilateral median, ulnar, common peroneal and tibial nerves involve the motor latency, compound motor action potential (CMAP), motor nerve conduction velocity (MNCV), conductions block and temporal dispersion.3. Minimal F wave latency of bilateral median, ulnar, common peroneal and tibial nerves.4. Needle EMG for bilateral proximal and distal muscles of upper (first dorsal interosseous) and lower limbs (tibialis anterior and extensor digitorium brevis) in which insertional activity, spontaneous activity, motor unit action potential MUAP and interference pattern were applied.The results of this study reveal that F wave and distal motor latencies of the left median, left ulnar, left peroneal, left tibial, right ulnar, right peroneal and right tibial nerves are significantly different between studied groups. Where there are prolonged latencies which could be considered as an indicator for admission to the RCU.Moreover, the reduced compound motor action potential (CMAP) and decrease conductive velocity (CV) in nearly all nerves are significantly different between studied groups and can also increase the chance for admission to the RCU.Concerning sensory abnormalities recorded in this study there are a reduced sensory nerve action potential of left median nerve or a prolonged left ulnar sensory latency when compared to the right ulnar and median sensory study and also increase the risk for admission to the RCU. Interestingly, what was noticed in this study, there are asymmetrical findings in nerve conductive parameters of the same patient involving not only the motor nerves rather than the sensory nerves too.This study concluded that the neurophysiological study can predict the severity of Guillain - Barre syndrome mainly the prolongation of F wave and motor latencies. The peripheral neurophysiological findings are useful in prediction of respiratory muscles involvement by GBS depending on CMAP and conductive velocity. There are asymmetrical finding changes in the studied neurophysiological parameters more apparently involving the sensory nerves of the same patients. Extremes of an age (<30yrs and >50yrs) represent a risk factor if not an indicator for RCU admission.
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