البحث — المستودع الرقمي العراقي

نتائج البحث: 25 من أصل 2,065

التقييم التجريبي لتاثير الروزفستاتين المضاد للالم والمضاد للالتهاب وتداخله مع السليكوكسب والباراسيتامول == Experimental Evaluation of The Antinociceptive And Anti - Inflammatory Effects of Rosuvastatin And Its Interaction With Celecoxib And Paracetamol

اسم المؤلف: سرمد عبد العباس كشمر

اسم المشرف: عبد الله محمد جواد

الموضوع العام: الطب

السنة: 2014

الموضوع الدقيق: الادوية والسموم

الدرجة: ماجستير

الجامعة: جامعة البصرة - كلية الطب - قسم الادوية

اللغة: الانكليزية

مكان الجامعة: البصرة

الصفحات الاولى:

المستخلص: اظهرت الدراسات بان الستاتينات تؤدي الى تقليل الوفيات بدرجة اكبر من ان تعزى الى تاثيرها الخافض للكوليستيرول بمفرده لان الفائدة حدثت بشكل اسرع مما يمكن تفسيره على وفق الالية سالفة الذكر. هذه الفوائد يمكن ان يكون لها علاقة بتاثيرات الستاتينات المضادة للالتها | Studies revealed that statins can result in a larger mortality benefits than can be readily explained by their cholesterol - lowering effect alone since they occur too quickly to be explained by the above cited mechanism. These benefits might be related to the anti - inflammatory and other effects statins may have.AimTo find out the extent to which rosuvastatin (a hydrophilic statin) can be considered as an antinociceptive and anti - inflammatory drug in comparison to two standard drugs; paracetamol and celecoxib, and whether its potential antinociceptive effect differs in different pain models. The interaction of rosuvastatin with paracetamol and celecoxib will also be investigated. MethodsMice (a total of 132) of either sex, 3 - 4 weeks of age, 20 - 25 gm body weight, were used (22 mice for each of six groups). Tests for nociception : tail flick, hot plate and formalin tests; and for inflammation (formalin for chronic inflammation, carrageenan - induced paw edema, and TNF - alpha level in blood) were used. Rosuvastatin (7mg/kg), paracetamol (40mg/kg), celecoxib (6mg/kg) or their combination were administered orally once daily in a volume of 0.2 ml. TNF alpha level in blood was measured using ELISA kit.ResultsThe antinociceptive effect of rosuvastatin when investigated in mice using tail flick, hot plate and formalin tests, showed that rosuvastatin has a mild antinociceptive effect which is much less than that of paracetamol and celecoxib tested in the same pain models. It increased the latency for tail flick by only 13.3% when compared to pre - treatment measurements, and in formalin test, it reduced the licking time by 20.9% in comparison to control. The administration of rosuvastatin with either paracetamol or celecoxib did not add to the antinociceptive effects of the latter two drugs (except in formalin test of pain model). None of the above mentioned drugs significantly reduced hind - paw edema when measured 24 hours after formalin injection, while they produced a significant edema - reducing effect after 14 days. Rosuvastatin and paracetamol had nearly similar effect (54.12% and 58.37% reduction compared with control). Celecoxib reduced the hind - paw edema by 73%. Again there was no additive effect between rosuvastatin and either paracetamol or celecoxib; in contrast, rosuvastatin reduced nearly all the effects of celecoxib when given in combination. Similar trend was found when edema was induced by carrageenan injection. TNF alpha level in blood had been reduced by all the three drugs and their combinations but did not reach statistical significance except in the group of rosuvastatin and paracetamol combination.ConclusionRosuvastatin showed a significant antinociceptive effect in tail flick and in formalin test, but not in hot plate test. It had anti - inflammatory and edema - reducing effects in models of inflammation in mice but the effect was less than that of celecoxib and even paracetamol. These rosuvastatin effects did not add to those of paracetamol and had caused a reduction in celecoxib (except for formalin pain model) effects when given in combination.

تاثير الايتانرسبت على السايتوكينات وموت الخلايا المبرمج جراء انقاص الارواء الدموي واعادته لعضلة القلب في ذكور الفاران == Effect of Etanercept Against Myocardial Ischemia/Reperfusion Injury In Male Mice

اسم المؤلف: سيف محمد حسن

اسم المشرف: نجاح رايش هادي الموسوي | فاضل غالي يوسف العمران

الموضوع العام: الطب

السنة: 2014

الموضوع الدقيق: الادوية والسموم

الدرجة: ماجستير

الجامعة: جامعة الكوفة - كلية الطب - قسم الادوية والعلاجيات

اللغة: الانكليزية

مكان الجامعة: النجف

الصفحات الاولى:

المستخلص: يمثل نقص ارواءعضلة القلب واعادة الارواء مشكلة ذات صلة سريريه مرتبطة بالجلطات والقسطرة وجراحة تغيير الشرايين التاجيه. تشمل اصابة عضلة القلب بسبب نقص التروية الدمويه واعادتها ضعف مقلص القلب، عدم انتظام ضربات القلب وكذلك تلف الخلايا العضلية التي لا رجعة في | Background : Myocardial ischemia - reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia - reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocytes damage. These changes are considered to be the consequence of imbalance between the formation of oxidants and the availability of endogenous antioxidants in the heart. Objective : This study was undertaken to investigate the potential role of etanercept in amelioration of myocardial I/R injury induced by ligation of coronary artery in a mice model.Material & method : adult male Albino mice were randomized into four equal groups.1. Group (1) : Sham group : mice underwent the same anesthetic and surgical procedure as the control group except ligation of LAD coronary artery.2. Group (2) : Control group : mice subjected to regional ischemia for 30 min by ligation of the LAD coronary artery and reperfusion for 2 hours.3. Group (3) : Control vehicle group : mice subjected to regional ischemia for 30 min by ligation of the LAD coronary artery and reperfusion for 2 hours and mice received vehicle of etanercept (normal saline) 5 minutes before reperfusion via I.P injection and.4. Group( 4) : Etanercept treated group : mice subjected to regional ischemia for 30 min by ligation of the LAD coronary artery and reperfusion for 2 hours and mice treated with etanercept 5mg/kg i.p 5 minutes before reperfusion XVIIIResults : Compared with the sham group, the levels of TNF - ? & IL - 1?, IL - 6, Caspase 3 and plasma level of cardiac troponin I increased in the control group but decreased level of Bcl - 2 (p<0.01).Histologically, all mice in the control group showed significant (p<0.01) cardiac injury and apoptosis.Etanercept significantly decreased in myocardium level of TNF - ?, IL - 1B, IL - 6,Caspase 3 , and plasma cTnI (P < 0.01), while significantly increased level of Bcl - 2 (P < 0.01). Histological analysis revealed that etanercept markedly reduced (P < 0.01) the severity of cardiac injury in the mice underwent LAD ligation procedure. : ionsConcluThe results of the present study reveal that etanercept may ameliorate myocardial I/R injury in mice via interfering with inflammatory reactions and apoptosis. : RecommendationAfter studying the results of the present study, the following recommendation to further1. Further measuring the P - selctine and E - selectine to show the effect of etanercept on rolling of eutrophils and platelets that cause further occlusion of blood vessels.2. Further measure the adiponectine (that have a cardioprotective effect ).

العلاقة بين اعتلال الجهاز العصبي اللاارادي الناتج عن السكري مع مستوى اللبتين وامراض القلب حسب فحص ايكو القلب وفحص اجهاد القلب == Relation of Diabetic Autonomic Neuropathy With Leptin And Cardiac Disease Assessed By Echo And Treadmill Test

اسم المؤلف: زينب فلاح حسن

اسم المشرف: احسان محمد عبود عجينة | علاء حسين عباس

الموضوع العام: الطب

السنة: 2014

الموضوع الدقيق: الفسلجة

الدرجة: دكتوراه

الجامعة: جامعة الكوفة - كلية الطب - قسم الفسلجة والفيزياء الطبية

اللغة: الانكليزية

مكان الجامعة: النجف

الصفحات الاولى:

المستخلص: الخلفية : الاعتلال العصبي اللاارادي القلبي له تاثير سلبي على الحياة ونوعيتها للاشخاص المصابين بالسكري. الاعتلال العصبي اللاارادي القلبي يعتبر نوع فرعي من الاعتلال العصبي السكري. هذا النوع من الاعتلال هو الاكثر بروزا لتهديده للحياة وبسبب توفر الفحص القلبي | Background : Cardiac autonomic neuropathy (CAN) has a negative effect on survival and quality of life in people with diabetes mellitus (DM) and is regarded as a subtype of the diabetic autonomic neuropathy. This type of neuropathy is the most prominent focusing because of its life threatening and the availability of the cardiovascular tests that can diagnose it. It has been thought that many factors in DM like leptin causing increase the risk of cardiovascular disease. Researches about the relation of leptin with CAN and cardiovascular disease are yet limited.Aim of study : This study aims to determine the prevalence of CAN in patients with type 2 diabetes mellitus, evaluate the association between CAN the presence of left ventricular dysfunction in these patients, test the association between CAN and ischemic heart disease and assess the relationship between the presence and severity of CAN with fasting serum leptin in these patients.Patients, materials and methods : This cross sectional study included 103 (56 males and 47 females) diabetic patients without hypertension or pre - diagnosis of ischemia. They had attended to the diabetic center in Marjan Medical City in Hilla from March 2013 to February 2014. The patients had undergone thorough assessments that included clinical (history and full examination) and biochemical assessments (measurement of fasting plasma sugar, glycated haemoglobin, lipid profile, blood urea, serum creatinine and serum leptin level). Cardiac autonomic reflex tests were also assessed along with echocardiography and treadmill test. Cardiac autonomic reflex tests included the five tests of Ewing protocol. Patients who had two or more abnormal tests were considered as having CAN (75 patients) and those with less than two abnormal tests were considered as patients without CAN (28 patients). Results : The study found that most diabetic patients (84%) were obese (BMI?25 kg/m2) and most of the diabetic patients presented with CAN (72.8%). Fasting serum leptin level was higher in female than in male in both study groups (with and without CAN). Patients with CAN were older when compared to patients without CAN (p?0.01) and had longer duration of DM (p?0.01) with significantly higher fasting serum leptin levels. The leptin level showed a tendency to increase as the score of CAN increased. However, these changes were not significant (P>0.05). The most abnormal sympathetic response was diastolic blood pressure response to hand grip while the most abnormal parasympathetic response was heart rate response to breathing. On contrary, the lowest abnormal response was found in postural blood pressure test. Echocardiography showed that most of the diabetic patients (89.8%) had a left ventricular hypertrophy by measuring the left ventricular mass index. However, there were no significant changes in echocardiographic results between patients with CAN and those without.Conclusions : This study concludes that CAN is a common complication of type 2 diabetes that affected a large percentage of diabetic patients. The duration of the diabetes and the age of patients are important non modifiable risk factors for the development of CAN. Additionally, heart rate variability is considered as an important test for early detection of CAN. On the other hand, CAN has no impact on the occurrence of left ventricular diastolic dysfunction. Leptin level was high in diabetic patients and even higher in those with CAN and its levels related positively with the severity of CAN. Also, there were high leptin levels in diabetic patients with positive treadmill test results, although these changes were not significant (P>0.05).

فاعليه تطبيق الممرضين للممارسات القياسية على العناية بالاطفال حديثي الولادة المصابين بمتلازمة كرب التنفس في وحده العناية بالاطفال حديثي الولادة في مستشفيات بغداد للاطفال التعليمية == Effectiveness of Nurses Application of Standard Practices On Care of Newborn With Respiratory Distress Syndrome In Neonatal Care Unit At Children And Maternity Teaching Hospitals

اسم المؤلف: محمد عزيز حسن

اسم المشرف: اقبال غانم علي معلة

الموضوع العام: الطب

السنة: 2014

الموضوع الدقيق: التمريض

الدرجة: دكتوراه

الجامعة: جامعة بغداد - كلية التمريض

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى:

المستخلص: اجريت دراسة شبه تجريبية في مستشفيات بغداد للاطفال التعليمية للفترة من 28 من كانون الثاني الى الاول من ايلول لسنة 2014 لتقييم فاعلية تطبيق الممارسات القياسية للممرضين والذين يتعاملون مع الاطفال حديثي الولادة المصابين بمتلازمة كرب التنفستم تقييم الحاجة من | A quasi experimental(interventional) study was carried out at Baghdad pediatric teaching hospitals in Baghdad from the 28th of January to the 1st of September 2014 to assess the effectiveness of the application of standardized practices to nurses dealing with neonate with respiratory distress syndrome. Assessment of needs was done to evaluate the nurses practices towards neonates with respiratory distress syndrome in neonatal care unit(NCU) by using a special format which includes multiples questions related to nurses knowledge and practices for 10 nurses works at the private Nursing home.The result of the assessment revealed that the nurses have poor knowledge and practices towards neonates with RDS. A pretest test was performed before the application of the program for 35 nurses, three of them was out of the study sample.Observation their practices based on the standardized items which was prepared by the researcher and extensive review of the literature. A non - probability (purposive) sample of 32 nurses who work in the neonate intensive wards was chosen to be involved in study sample, and an educational program was designed based on the results and basic nursing guidelines related to care for neonate with respiratory distress syndrome, it consists of two parts : the first part consists of demographic data, and the second part consists of an observational checklist format related to the nurses practices in care of neonate with respiratory distress syndrome. The questionnaire was used to observe the nurses practices in the pre - test applied before the program started , post - test 1 immediately after the application of the program, post test 2 after 1 month from the post test 1,and a post 3 after 2 months from the second post test. The reliability of the questionnaire was conducted through a pilot study and validity through a panel of experts. The data were analyzed through the application of a descriptive statistics frequencies ,percentages ,and application of inferential statistical procedures which include Pearson correlation coefficient and paired test. The finding of the study revealed that the nurses practices towards neonates with respiratory distress syndrome were improved after the implementation of the program in most of the items of the post test 1 ,2,and 3 of the program, and there is a significant association between nurses' practices and their level of education in most of the program items, There was also a significant association between nurses practices and years of their experiences. The study recommended increasing knowledge and practices of the nurses working in the neonatal care unit through regular training courses, in addition to increasing the number of graduated nurses from the College of Nursing in this critical unit.

تاثير البرنامج التثقيفي التمريضي على معارف وممارسات الملاك التمريضي ازاء التاهيل القلبي لمرضى النوبة القلبية == The Effectiveness of Nursing Educational Program On Nurses Knowledge And Practices Toward Cardiac Rehabilitation For Patients With Heart Attack

اسم المؤلف: احمد عجلان علاوي ناصر

اسم المشرف: حكيمة شاكر حسن

الموضوع العام: الطب

السنة: 2014

الموضوع الدقيق: التمريض

الدرجة: دكتوراه

الجامعة: جامعة بغداد - كلية التمريض

اللغة: الانكليزية

مكان الجامعة: بغداد

الصفحات الاولى:

المستخلص: اجريت دراسة شبه تجريبية في مستشفى الشيخ زايد ومستشفى الصدر العام ومستشفى الكرخ العام ومستشفى الكرامة ومدينة الامامين الكاظمين الطبية ومستشفى بغداد التعليمي للفترة من الاول من ايلول2013 الى الاول من ايلول2014 تهدف الدراسة الى تقويم فاعلية البرنامج ال | A quasi - experimental design study was carried out at the AL - Sheikh Zayed hospital; AL - Sader; Al - Karkh ;AL - Karama ;Imameinkadhimein medical city and Baghdad Teaching hospital during the period from 1st September 2013 to 1st September 2014. The objective of the present study is to evaluate the effectiveness of nursing education program on the nurses knowledge and practice toward cardiac rehabilitation phase one for patients with heart attackThe program and instrument were constructed and developed by the researcher for the purpose of the study A random sample composed of (80) nurses was divided into two groups , the experimental group consisted of (40) nurses exposed to the nursing educational program and control group consisted of (40) nurses were not exposed to the program.Reliability of instrument was determined through the use of test and retest for the knowledge test and inter - observation for practice and the instrument validity was determined through a panel of experts. The instrument to measure the effectiveness of nursing educational program on nurses knowledge and practice included (30) items concerning the nurses knowledge and 58 items included nurses practice nurses practices toward cardiac rehabilitation phase one for patients with heart attack.The analysis of data was performed through the application of description statistic(Frequencies, Percents, and Cumulative Percentages , Mean of Score , Standard Deviation , Relative Sufficiency ) and Inferential statistical (Contingency Coefficients , Chi - Square test , Fisher to present the differences between the experimental and control groups. The results of the study shows that the nursing educational program regarding nurses knowledge toward cardiac rehabilitation program phase one is effective. They also shows that there is a good improvement with highly statistically significant differences between pre - post tests of experimental group in overall domains related to nurses practice in items of health assessment heart, assessment chest pain, cardiogenic shock, daily activity living and health education. The study concluded that the nurses working in coronary care unit have deficient knowledge and practices toward cardiac rehabilitation phase one for patient with heart attack. The study also confirms that the instruction oriented program on nurses in the experimental group is successful. The study recommended that the nurses staff can be encouraged and having motivation for being participated in the special training programs and conference to fulfill the nurses needs concerning defects and limitations ed in their practice toward cardiac rehabilitation phase one for patient with heart attack.