مكان الجامعة: القادسية

الصفحات الاولى:

الملخص:

المصادر:

منطقة الفرات الاوسط في كتب الرحالة الاجانب 1831 - 1914م Middle Euphrates Area In Forigner Royagers Books (1831 - 1914)

اسم المؤلف: محمد جبار موسى

اسم المشرف: علي عبد الواحد حسون الصائغ

الموضوع العام: التاريخ

السنة: 2014

الموضوع الدقيق: التاريخ الحديث والمعاصر

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم التاريخ

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

الملخص:

المصادر:

الملكة عالية : سيرتها ونشاطها الاجتماعي في العراق 1911 - 1950

اسم المؤلف: قاسم حلو كوثر الغرابي

اسم المشرف: فرقان فيصل جدعان الغانمي

الموضوع العام: التاريخ

السنة: 2014

الموضوع الدقيق: التاريخ الحديث والمعاصر

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم التاريخ

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

الملخص:

المصادر:

الدغارة دراسة في احوالها الاجتماعية والاقتصادية والسياسية 1921 - 1958 Dagharah Study in its Social, Economic and Political Situations (1921 - 1958)

اسم المؤلف: محمود جبار كاظم العبودي

اسم المشرف: علي عبد الواحد حسون الصائغ

الموضوع العام: التاريخ

السنة: 2014

الموضوع الدقيق: التاريخ الحديث والمعاصر

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم التاريخ

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

الملخص:

تحضير مشتق جديد للبايروزولون ازو واستعماله في تقدير الكميات الضئيلة لبعض الايونات الفلزية بالطرائق الطيفية Preparation of New Pyrozolone Azo Derivative And Use It For Micro Determination of Some Metal Ions By Spectrophotometric Methods

اسم المؤلف: شيماء حسن ملاح

اسم المشرف: حسين جاسم محمد

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: تضمن البحث تحضير الكاشف الجديد 3 - (?4 - انتي بايرايل ازو) - 1 - نايتروزو - 2 - نفثول واجراء دراسة اولية مع (9) ايون فلزي واستحداث طريقة طيفية لتقدير كل من النحاس (II) والكوبلت (II) بهذا الكاشف في الوسط المائي، اذ كان الطول الموجي الاعظم للكاشف (374) نان | The research includes primary study of the reaction of 3 - (4? - Antipyriyl azo) - 1 - Nitroso - 2 - naphthol (APANN) with (9) metal ions and spectrophotometric method for the determination of copper (II) and Cobalt (II) ions with this reagent. The wavelength of maximum absorption (?max) for the reagent is (374) nm and for complexes formed between these ions with this reagent was found at (430.5) nm and (432) nm for both copper (II) and Cobalt (II( respectively in aqueous medium, also the optimum conditions for the reaction of these ions with the reagent were employed ,such as the volume of reagent solution, time, temperature, type of buffer, order of addition and effect of pH, calibration curves of these complexes were constructed. Beer's law was obeyed in the range (0.1 - 2.5) ppm of copper with a correlation coefficient (R2= 0.9971) and molar absorptivity ? = 1.83 × 104 L.mole - 1.cm - 1 and Sandell sensitivity was (0.00349) ?g.cm2 - , as for Cobalt, the range was (0.1 - 2.5) ppm with a correlation coefficient (R2= 0.9965) and molar absorptivity ? = ) 3.3×104 ( L.mol - 1.cm - 1 ,and Sandell sensitivity was (0.0018)µg.cm - 2. The stoichiometry of the formed soluble complexes between copper (II) and Cobalt(II) with reagent was investigated by both the continuous variations method and mole ratio method, the ratio (M : L) was (1 : 2) for Copper complex and Cobalt complex at pH (8.5) for both complexes. The stability constant (Ksta) for the complexes of copper (II) and Cobalt (II( was equal to (8.237 ×108 L.mol - 1) and (1× 108 L.mol - 1) respectively. Precision and accuracy of the analytical procedure were showed for (0.5) ppm of Cu (II) and Co (II) that R.S.D.% was equal to (0.97), (0.73) , (Erel, Re)% (0.6, 99.4)%, (0.4, 99.6)% for these ions, respectively. The analytical procedure were showed for (1) ppm of Cu (II) and Co (II) R.S.D.% was equal to (0.41,0.60) , (Erel, Re)% (0.3, 99.7)%,(0.2, 99.8)% for these ions respectively. The interference of metal ions in the presence of related ions was determined, as well as, masking of these ions by suitable masking agents was studied. The study of effect of three kinds of surfactants on the absorptions of the complexes and calculation of stability constants and treatment of the results statistically and make comparison with aqueous medium were done. The physical properties of precipitants were studied through the establishment of melting point, solubility and molar conductivity as well as the measurement of infrared spectra , and C.H.N, with the suggestion of structural formula of the formed complexes with the reagent (APANN). The method was applied for the determination of the content of copper (II) in tea leaves samples and Cobalt (II) in raw caw milk samples. Finally ,The biological activity of these complexes was tested with four types of bacteria.

تحضير وتشخيص ودراسة الفعالية البايولوجية لبعض مشتقات البريميدين الجديدة بتطبيق تفاعل سوزوكي Synthesis And Characterization And Biological Activity Study of Some New Pyrimidine Derivatives Via Application Suzuki Reaction

اسم المؤلف: رؤى جميل كامل

اسم المشرف: نبيل عبد عبد الرضا

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء العضوية

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: تضمنت الرسالة تحضير وتشخيص عدد من مشتقات البريميدين الجديدة من خلال تطبيق تفاعل سوزوكي، كما شملت الرسالة الفعالية البايولوجية للمركبات المحضرة ضد فيروس الايدز، تم انجاز موضوع الرسالة بتطبيق الاجزاء التالية : الجزء الاول تحضير المركبات 99 , 101 , 103 , 1 | The thesis included a detailed study of the biological importance of Pyrimidines compounds. The literature screening included the synthesis of different derivatives of pyrimidines compounds as well as their chemical reactivity , in addition to the experimental part which included the chemical procedures for preparation of the new derivatives of pyrimidine. New pyrimidine derivatives have been prepared by several parts : The first part include preparation of compounds 99 , 101 , 103 , 105 , 107 , 108 , 110 , 112 , 114 , 116 by Suzuki coupling reaction via reaction of uracil derivatived with the aromatic boronic acids to give new derivatives.The second part includes preparation of pyrimidine derived 117 by nitration of compound 42 using of concentrated nitric acid with concentrated sulfuric acid and preparation of new derivatives starting from compound 117 via Suzuki coupling reaction with some aromatic boronic acids.The third part includes includes preparation of new two compounds derived from compound 120 via Suzuki coupling reaction with the different boronic acides. The fourth part includes preparation of pyrimidine derivatives 126 by reaction of pyrimidine derivatives 120 with para - chloroaniline via coupling reaction to give the new derivative of azo pyrimdine dye.The fifth part includes preparation of new two compounds derived from compound 126 via Suzuki coupling reaction with the different boronic acides.As well as the thesis which us discussed the preparation and identification of new pyrimidine derivatives from throough spectra (I.R) , (1H - NMR) , (13C - NMR) and (C.H.N) and specta (HSQC) , (COSY) and (HMBC). For some of these compounds, and these identification studies approved the correctness of the chemical structures for the prepared derivatives. As well as in the thesis is included biological activity against AIDS. Scheme (1)R NO. R NO.4 - OH 96 4 - CHO 984 - OMe 109 4 - Cl 1004 - CN 111 4 - OEt 1024 - CF3 113 4 - OMe 1043,4 - OMe 115 4 - Br 106 (A) : (Ph3P)4Pd, Na2CO3, n - PrOH, Reflux(B) : NaNO2, HCl, (0 - 5)C°, 16h.

تحضير وتشخيص الليكاند 7 - ]2 - (بنزاميدازوليل) ازو [ - 8 - هيدروكسي كوينولين مع بعض ايونات العناصر الانتقالية ودراستها ضوئيا Preparation And Identification of Ligand 7 - [2 - (Benz Imidazolyl)Azo] - 8 - Hydroxy Quinoline (BIAHQ) And With Some of Transition Elements Ions And Photo Study

اسم المؤلف: سؤدد عبد الباقر جابر

اسم المشرف: حسن عباس حبيب خالد جواد العادلي

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: لقد تضمنت هذه الرسالة تحضير نوع جديد من ليكاندات الازو العضوية غير المتجانسة حلقيا الحاوية على مجموعة ازو واحـدة وهو الليكاند 7 - ]2 - (بنزاميدازوليل ازو[ - 8 - هيدروكسي كوينولين(BIAHQ).وقد تم تشخيص هذا الليكاند بوساطة طيف الكتلة وبروتون طيف الرنين الن | This research included prepare a new ligand of azo organic heterocyclic ring containing one azo group which ligand 7 - [2 - (Benzimidazolyl azo) - 8 - hydroxy quinoline] (BIAHQ). Has been identification this ligand by mass spectrometry , proton nuclear magnetic resonance spectra ,infrared and UV - visible as well as analysis of the elements(C,H,N), included the preparation of four complexes of ligand (BIAHQ) with metal ions Co 2+ , Ni 2+,Cu 2+ and Zn2+ also studied the spectra of infrared spectra of the complexes prepared, and when compared with the spectra of the free ligand gave the obvious changes have shown these spectra a new peaks were not already present in the spectra ligand This is due to corrdenation between the metal ions under study with the atoms donor nitrogen group azo and nitrogen atom imidazole ring (N3) in the molecule of ligand, suffered with other peakes obvious changes in the shape, intensity and location, and an indication of this process for corrdenation between the metal ions under study and ligand, also studied the spectra of UV - visible, as well as a rigorous analysis of the elements (C,H,N) has been shown by the results agreat compatibility between the ratios calculated theoretically and practically of acquired. Through the results that have been reached suggested formulas compositional complexes showing through which that ligand azo imidazole mono - azo behave as ligand Triplalt coordenat through a nitrogen atom imidazole ring (N3),nitrogen group azo away from the ring heterogeneous and Oxygen of hydroxy quinoline group, which leads to the formation of complexes hexagonal symmetry. Studied the kinetics of photochemical dissociation of these complexes claw through irradiation solution single - wavelength light 365=? nm issued by the mercury lamp low pressure and at a temperature of 25 ?c and show that the interaction of dislocation is first order for all complexes. Was calculated photolysis rate constant kd mediated follow spectral changes during the process of irradiation. For access to the optimum conditions for the dissolution of these complexes have been studying the impact of several factors on the behavior of photochemical included : study the effect of the change in the intensity of light on the rate of disintegration and found that the increas in the intensity of the incident light increased the rate of disintegration of the complexes , as well as the study of the disintegration of the complexes in the temperature range 30 - 15?c found it increasing the temperature increases rate of disintegration. Values were calculated activation energy for all complexes , also studied the effect of the acidic function within the range of 9.3 and found that the rate of the disintegration of the four complexes increases with increasing pH solution. It was the study of the effect of the solvent polarity on the rate of disintegration using solvents ( methanol , ethanol,1 - butanol and isopropanol ) and found that the higher the rate of the disintegration of the complexes have been achieved in methanol , while lower rate was in isopropanol.Also thermal stability studied for ligand and complexes were submitted to thermal analysis (TGA and DSC) activation thermodynamic data are calculated and determainTg ,Tc , Tm and Td.

تحضير ودراسة الفعالية الحيوية لبعض مشتقات الكرمارين الجديدة Synthesis And Study Biological Activity of Some New Coumarin Derivatives

اسم المؤلف: قاسم عبد الحسين جابر الشيباني

اسم المشرف: نبيل عبد عبد الرضا

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: تم في هذه الدراسة تحضير المعقدات على النحو الاتي : 1 - اوكسو 1,1 - ثنائي مثيل هايدرازيدو - ثنائي( ثنائي اثيل ثنائي ثايوكارباماتو) موليبدنيوم (VI) 2 - اوكسو 1,1 - ثنائي مثيل هايدرازيدو - ثنائي(ثنائي مثيل ثنائي ثايوكارباماتو) موليبدنيوم (VI) 3 - اوكسو 2,1 | In this study for complexes have been prepared are : 1 - Oxo 1,1 - dimethyl hydrazido - bis (diethyl dithiocarbamato) molybdenum (VI). 2 - Oxo 1,1 - dimethyl hydrazido - bis (dimethyl dithiocarbamato) molybdenum (VI) 3 - Oxo 1,2 - dimethyl hydrazido - bis (diethyl dithiocarbamato) molybdenum (VI). 4 - Oxo 1,2 - dimethyl hydrazido - bis (dimethyl dithiocarbamato) molybdenum (VI). Via two intermediate complexes are di oxo bis (diethyl dithiocarbamato) molybdenum (VI) and di oxo bis (dimethyl di thiocarbamato) molybdenum (VI). All complexes was characterized spectrophometically by UV - vis and FTIR. The kinetic of photo chemical reaction have been studied for these complexes by irradiate there solution by mono wave length light at (?= 366nm)supplied from medium pressure mercury lamp at 293 K for 90 minutes by using ethanol as solvent. Following the photo chemical reaction showed the order of photo dissociation reaction is pseudo - first reaction for all complexes and reaction rate constants were calculated , so the spectrum change were recorded during irradiation period. The effect of several factors have been studied included : period of irradiation , complex concentration , light intensity , PH value , solvent polarity and temperature. Where the periods of irradiation time were followed which last in the complex dissociation , were between 390 - 450 min. study of seven concentration of all complex where the dissociation rate was proportional inversty with concentration , so the dissociation increases when light intensity increase , and notice that changing in pH value between 4 - 10 lead to dissociation increment toward naturalization and decrease when alkalinity rise. According to the solvent effect , the photodissociation take the sequence for all complexes Isopropanol > 1 - butanol > Ethanol > Methanol. Besides the photo dissociation of all complexes was studied in the range 283 - 303 K and found that in the temperature rising the rate of dissociation rises and the activation energy for all complexes and study was calculated. Quantum yields have been calculated for all prepared complexes and the value was more than one , it raters to the photolysis was chain reaction and reaction done by heterogonous splitting of metal - ligand bond according to uv - vis spectrums where oxidation of ligand and the metal was reduced giving opposite complexes

تحضير وتشخيص مشتقات جديدة للاندنول تحمل حلقات غير متجانسة متنوعة Synthesis And Characterization of New Indole Derivatives Bearing Various Hetero Rings

اسم المؤلف: كاظم ماذي لازم العلياوي

اسم المشرف: جمبد هرمز توما خالد فهد علي

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء العضوية

الدرجة: دكتوراه

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: الانكليزية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: تتضمن هذه الاطروحة تحضير وتشخيص بعض مشتقات السكارين العضوية ومعقدات السكارين ومشتقاته الفوسفينية مع بعض الفلزات، حيث استخدم سكارينات الصوديوم والسكارين كمواد اولية للتحضير وكما ياتي : 1 - حضر N - كلور اسيتل سكارين (A2) من تفاعل السكارين مع كلور استيل كلور | This thesis include synthesis and characterization of some organic saccharin derivatives and metal complexes of saccharin and its phosphine derivatives are synthesized in this work according to the following : 1. The N - Chloro acetyl saccharin (A2) is prepared from the reaction of saccharin with chloro acetyl chloride, in presence of Et3N in 1,4 Dioxan. The N - (2 - aryl amino) acetyl saccharine (A3 - A9) is synthesized from the reaction of compound (A2) with the substituted amin.The N - (2 - Saccharin - 2yl) acetyl saccharine A(10) is prepared from reaction of two mole saccharin with mole chloro acetyl chloride in presence of Et3N in 1,4Dioxin.2. Mannich Bases (A11 - A26) are prepared from the reaction of saccharin with substituted primary amin and fromaldehyde in methanol.3. N - Hydroxy methyl saccharin (A27) is prepared from the reaction of saccharin with formaldehyde in H2O or EtOH. The N - methylacetat saccharin (A28) is prepared from the reaction of compound (A27) with acetic anhydride in the presence of NaOH.4. (3 - Benzosulfonamide2 - Carboxylicacid2 - yl)2 - imino thiazolidin - 4 - (one) (A29) is prepared from the reaction of compound (A2) with KSCN in acetone.5. N - Benzoyl Saccharin (A30) is prepared from the reaction of saccharin with Benzoyl Chloride in acetone in the presence of NaHCO3.6. N - acetyl Saccharin(A31) is prepared from the reaction saccharin with acetyl chloride in DMF in the presence of Et3N also N - acetyl saccharin (A49) is prepared from the reaction of sodium saccharin with acetyl chloride in DMF. The N - acetyl saccharine is used in the preparation of ? - ? - Unsaturated carbonyl compounds(A50 - A54) through its reaction with substituted benzaldehyde , and also N - acetyl saccharin is used in the preparation of Schiff bass A(55 - 58) through its reaction with substituted amine.7. N - acetonyl saccharin (A32) is prepared from the reaction of sodium saccharin with chloro aceton in DMF. The N - acetonyl saccharin is used in the preparation of Schiff base A(33 - 38) through its reaction with substituted of amine and also N - Acetonyl saccharin is used in the.preparation.of? - ? - Unsaturated.carbonyl.compound(A39 - A45) through its reaction with substituted benzaldehyde.8. N - saccharinato acetic acid (A46) is prepared from the reaction of sodium saccharin with chloro acetic acid in DMF. The N - saccharinato acetic acid used in the preparation of 5 - (N - Saccharin) methyl )2 - amino - 1,2,3 thiadiazol (A47) through its reaction with thio semicarbazide in toluene and also N - Acetic acid saccharin is used preparation of N - ((1H - benzo[d]imidozol - 2yl)methyl) Saccharin (A48) through its reaction with O - Phenyl diamine.9. N - 3 - bromopropyl saccharin (A59) is prepared from the reaction of sodium saccharin with 1,3 dibromopropan in DMF.10. 2 - ChloroN - (4 - (2 - methaoxazol - 5yl)sulfamoyl)phenyl)acetamide (A60)is prepared from the reaction of4 - aminosulphamethaoxazol with chloroacetyl chlorid in 1,4dioxan in the presence of Et3N.2 - saccharin - N(4 - (2 - methyloxazol - 5yl)sulfamoyl)phenyl acetamide(A61)is.prepared from the reaction of sodium saccharin with (A6o)in DMF11. N - ethyl acetate saccharin A(62) is prepared from the reaction of sodium saccharin with chloro ethyl acetate in DMF. The N - acetic acid saccharin (A63) is prepared from the acidic hydrolysis of N - ethylsaccharin acetate by HCl , CH3COOH.The N - (acetyl thiosemicarbazide)saccharine(A64) is prepared from in the reaction of thiosemicarbazide with (A62)in acetone.The 5 - ((N - Saccharin )methyl) - 1,3,4 - thiadiaezol A(65) is synthesized in ring closur reaction by compound (A64) by sulfuric acid.12. N - Diphenyl phosphin saccharin (66) is prepared from the reaction of sodium saccharin with chloro diphenyl phosphine in dry ether. The N - diphenyl phosphin saccharin is used in the preparation of the complexe of the type [M CL2L2] , M=Pt(II) , Pd(II), Ni(II), L = Diphenyl phosphin saccharin [A70 - 72] through its reaction with Na2PdCl4 , PtCl2(DMSO)2,NiCl2 - 6H2O in CH2Cl2 or aceton in which N - Phenyl phosphin saccharin Ligands berhaves as amono dentat and coordinat through (P) atom to Metal.13. Aqua saccharin complexes of the type [M(Sac)2(H2O)4] 2H2O , (M=Ni,Co,Fe,Zn,Mn,Cd,Cu)(A73 - 79) are prepared from reaction sodium saccharin with divalent metal ions from (Ni,Co,Fe,Zn,Mn,Cd,Cu) in which saccharin Ligands behave amono dentate and coordinate through (N) atom to metal.Treament of (dppe , dppm) with aqua saccharinat complexes(A80 - A88) in CH2Cl2 gave complexes of this type.The treatment of dppe with aqua saccharinat complexes of the (Cd,Zn,Fe,Mn)(A79,A78 ,A76,A75)give complexes (A80 - A83)of this type [M(Sac)2(dppe)2], the dppe in these complexes coordinate as abidentate. but treatment of dppe with aqua saccharinat of the (Ni,Co)(A73,A74) gave complexes (A84,A85)of this type [M(Sac)2(dppe)], but treatment of dppe with aqua saccharinat complexes of the (Cu)(A77) , gave complexes(A86) of this type [Cu(Sac)dppe]. The treatment of dppm with aqua saccharinato complexes of the (Cd,Zn)(A78,A79) gave complexes (A87,A88) of this type [M(Sac)2(dppm)2].The structure of the synthesized compound are confirmed by I.R , H1 - N.M.R,C13 - N.M.R,Elemental analysis , molar conductivity and some chemical physical data.

تحضيروتشخيص بعض المشتقات الجديدة لثنائي هيدروبريميدينون باستخدام تفاعل بكينيلي ودراسة فعاليتها البايلوجية Synthesis And Characterization And Biological Activity Study of Some New Dihydropyrimidinones Derivatives Via Application Biginelli Reaction

اسم المؤلف: احمد ماهر فهيم

اسم المشرف: نبيل عبد عبد الرضا

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء

الدرجة: دكتوراه

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: The present work involved synthesis of new indole derivatives containing other heterocyclic ring. These derivatives could be divided into the following parts : 1. The first part involved synthesis and characterization of novel 1,3 - diazidine[XIII]a - d and [XIV]a - d by the following steps : Scheme(1).a. Synthesis of 3 - [(5 - hydrazinyl - 4 - phenyl - 1,2,4 - triazol - 3 - yl)methyl] - 1H - indole [VI], this compound is synthesized by neucleophilic substitution reaction of 1,2,4 - triazole - 5 - thiol compound [V]a with excess of hydrazine hydrate in absolute ethanol as a solvent.b. Synthesis of 2 - {5 - [(1H - indol - 3 - yl) - propyl] - 4 - phenyl - 1,2,4 - triazol - 3 - yl} - thio - acetohydrazide[VIII]b, by the reaction of ester compounds[VII]b with excess of 80% hydrazine hydrate in ethanol under reflux.c. Synthesis of new Schiff bases[IX]a - d and [X]a - d by condensation reaction of primary amino compounds[VI] or [VIII]b with different aromatic aldehyde in absolute ethanol as a solvent.d. Synthesis of new N - acyl derivatives[XI]a - d and [XII]a - d by reaction of acetyl chloride with the synthesized Schiff bases[IX]a - d, [X] a - d in dry benzene.e. Synthesis of 1, 3 - diazetine derivatives[XIII]a - d and [XIV]a - d by addition reaction of compound[XI]a - d or [XII]a - d with sodium azide in dimethylformamid as a solvent at (55 - 60)0C temperature.2 - While the second part involved synthesis and characterization of novel thiazolidine - 4 - one compounds[XXI]a - d and [XXII]a - d by the following steps : Scheme(2).a. Synthesis of 2 - [5 - (2 - methyl - 1H - indol - 3 - yl) - 4H - 1,2,4 - triazol - yl] - thio - ethyl hydrazide[XVIII] by the reaction of ester compound[XVII] with excess of 80% hydrazine hydrate in ethanol under reflux.b. Synthesis of 2 - {5 - [(1H - indol - 3 - yl) - methylene] - 4 - phenyl - 1,2,4 - triazol - 3 - yl} - IXthio - ethylhydrazide[XVIII], by the reaction of ester compounds[XVII] with excess of hydrazine hydrate in ethanol under reflux. Also synthesize new Schiff bases [XIX]a - d and [XX]a - d by condensation reaction of acid hydrazide compounds [VIII]a or [XVIII] with different aromatic aldehyde in absolute ethanol as a solvent.c. Synthesis of new thiazolidine - 4 - one derivatives, [XXI]a - d and [XXII]a - d by refluxing equimolar amounts from Schiff bases[XIX]a - d and [XX]a - d with excess of thioglycolic acid in dry benzene.3. The third part involved synthesis and characterization of new series of thiazolidine - 4 - one [XXVII]a - c and [XXVIII]a - c by many steps reaction as follows : Scheme(3).a. Synthesis of new Schiff [XXIII]a,b, [XXIV]a,b by condensation reaction of acid hydrazide [III]a,b with two types of aromatic aldehyde in absolute ethanol.b. Synthesis of another type from thiazolidine - 4 - one derivatives [XXV]a, b and [XXVI]a, b from the reaction of Schiff bases [XXIII]a,b, [XXIV] a,b with excess of thioglycolic acid in dry benzene. The alkoxy derivatives of compounds [XXVII] and [XXVIII]; 2 - (4 - N - alkoxyphenyl) - 3 - (2 - methyl - 1H - indol - 3 - yl)amido - 1,3 - thiazolidine - 4 - one[XXVII]a - c and 2 - (4 - N - alkoxyphenyl) - 3 - (1H - indol - 3 - yl) acetamido - 1,3 - thiazolidine - 4 - one [XXVIII]a - c were synthesized by the reaction of terminal OH group of compound[XXV]a or [XXVI]a with different n - alkyl bromide in alkaline media.4 - The fourth part involved synthesis and characterization of amide derivatives of 1,3,4 - thiadiazole[XXXI]a - d, [XXXII]a - d and [XXXIII]a - d by the following steps : Scheme(4)a. Preparation of 2 - amino - 5 - (2 - methyl - 1H - indol - 3 - yl) - 1,3,4 - thiadiazole[XXIX] by cyclization reaction of 2 - (2 - methyl - 1H - indole - 3 - carbonyl) hydrazine carbo - thio amide [XV] in conc. H2SO4 under reflux followed by neutralized with liquid ammonia. While 2 - amino - 5 - [(1H - indol - 3 - yl)methyl] - 1,3,4 - thiadiazole[XXX]aand 2 - amino - 5 - [(1H - indol - 3 - yl)propyl] - 1,3,4 - thiadiazole[XXX]b synthesized by cyclization reaction under reflux of indole - 3 - acetic acid or indole - 3 - butric acid with thiosemicarbazide in the presence of phosphorous oxychloride.b. Synthesis of new amide derived from 2 - amino - 1,3,4 - thiadiazole [XXXI]a - d, [XXXII]a - d and [XXXIII]a - d from the reaction equimolar of suitable 2 - amino - 1,3,4 - thiadiazoles[XXIX] and [XXX]a,b with different acid chlorides in DMF and pyridine as accepter.5. The fifth part involved synthesis and characterization of new hydrazones [XXXVII]a - d and [XXXVIII]a - d. These compounds were synthesized according to the follows steps : Scheme(5)a. Synthesis and characterization of 1 - (2 - methyl - 1H - indole - 3 - yl) carbonyl - 3 - methyl - pyrazol - 5(4H) - one[XXXIV] and 1 - [(1H - indol - 3 - yl) ethanoyl or butanoyl] - 3 - methyl - pyrazol - 5(4H) - one [XXXV]a, b by heating under reflux a solution of equimolar from acid hydrazides[III]a - c with ethylacetoacetate in absolute ethanol.b. Synthesis and characterization of 1 - [4 - acetyl - (1H - indol - 3 - yl)ethanoyl or butanoyl] - 3 - methyl - pyrazol - 5 - one [XXXVI]a, b through reaction of pyrazolone derivatives[XXXV]a,b with acetyl chloride in 1,4 - dioxane in presence of calcium hydroxide.c. Synthesis and characterization of novel hydrazones [XXXVII]a - d and [XXXVIII]a - d by the reaction of 4 - acetyl - pyrazolone compounds[XXXVI]a, b with phenyl hydrazine or substituted phenyl hydrazine in ethanol.The synthesized compounds have been characterized by their melting points, elemental analysis (C.H.N) and by their spectral data, FTIR, 1HNMR and Mass spectroscopy (of some of theme).Study of the biological activity of some of the synthesized compounds against Gram - positive bacteria (Staphylococcus aureus) and Gram - negative bacteria (Escherichia coli). The results showed that most of the tested

تحضير وتشخيص بعض المشتقات الجديدة للمركب بارا - برومو انيلين ودراسة فعاليتها البايولوجية كمضادات (HIV) Preparation And Identification of Some New Derivatives of P - Bromoaniline And Study In Vitro Anti - Hiv Assay

اسم المؤلف: رعد سعد جهاد

اسم المشرف: نجم عبود لعيبي المسعودي نبيل عبد عبد الرضا

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: بهدف التوصل الى ايجاد سطوح انتقائية طبيعية وذات فعالية عالية في امتزاز بعض المواد الدوائية , اجريت دراسة متكاملة لانظمة الامتزاز للمادة الدوائية التتراسيكلين ( Tetracycline ( في درجات حرارية مختلفة على سطح البوكسايت والبوكسايت المعدل )البوليمر(.حيث تم ف | In order to reach to find a natural selective surfaces and highly effective in the adsorption of some pharmaceuticals, it has been a comprehensive study of the adsorption systems for the pharmaceutical substance Tetracycline in different conditions of temperature, on the surface of bauxite and modified bauxite. In this study the bauxite has been activated and used to prepare two complexes : bauxite - urea and bauxite - melamine, these complexes were merged and polymerized with to prepare the complex bauxite polymer - urea - melamine - formaldehyde (modified bauxite).The complexes bauxite - urea and bauxite - Melamine were characterized by X - ray diffraction (XRD) and infrared spectroscopy (FT - IR), while the surface of bauxite and modified bauxite are characterized before and after the adsorption by X - ray diffraction techniques (XRD), infrared spectroscopy (FT - IR), atomic force microscope (AFM) and scanning electron microscopy (SEM), where measurements showed that the presence of two types of minerals included in the structure of bauxite which they are Gibsite and Buhimite in addition to small amounts of other minerals.(UV - visb.) Technique was used to investigate the adsorption quantitatively on the surfaces of bauxite and modified bauxite at the following temperatures (293,298,303,308,313,318 K).Search has been expanded to include also the study of adsorption kinetics of the drug substance (tetracycline) on surfaces mentioned above. It has been found that the surfaces of bauxite and modified bauxite used in the study have a ranking below in its ability to adsorption of drug substance : Bauxite> PolymerResults of the study also showed the applicability of Frendilh equation model for adsorption of drug substance on the surface of the above - mentioned bauxite and applicability to Langmiur equation for the adsorption of drug substance on the surface of modified bauxite. The isotherms of adsorption takes shape (S2max) at low temperatures and then start to turn into shape (L2max) at high temperatures in the adsorption of tetracycline on the surface of bauxite, while taking shape (Lmax)at low temperatures and then start to turn into shape (Smax) at high temperatures when the adsorption of drug substance took place on the surface of the modified bauxite.Thermodynamic quantities Have been calculated, it’s found that the adsorption of drug substance on the surface of bauxite and modified bauxite is endothermic when the adsorption constant calculated at greatest concentration while the adsorption of drug substance on the surface of bauxite was endothermic and exothermic on the surface of modified bauxite if the adsorption constant calculated at infinite dilution.The kinetic study of the adsorption of the drug substance on the above surfaces according to the developed Lagergreen equation then the rate constant of the process has been calculated at temperatures (293,298,303,308,313,318 K), through these values the activation energy value and the value of Arhiniuos coefficient have been calculated adsorption process, it was found that the value of activation energy and the value of the Arhiniuos coefficient follow the order below : Polymer> BauxiteAlso the surface area of the surfaces of bauxite and modified bauxite follow the order : Bauxite> Polymer

تحضير ودراسة طيفية لمعقدات مزيج الليكاند لايونات بعض العناصر الانتقالية

اسم المؤلف: عباس سامي عبد

اسم المشرف: عبد الله محمد علي حبيبان مسلم حسن محمد

الموضوع العام: علوم الكيمياء

السنة: 2014

الموضوع الدقيق: الكيمياء

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم الكيمياء

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: تضمنت الدراسة تحضير عدد من المشتقات الحلقية غير المتجانسة بالاضافة الى بعض المشتقات ثنائية الاريل والتي تعد ذات اهمية في مجال الكيمياء الطبية ,ونواة لتحضير بعض المشتقات الكيميائية الاخرى للمركب بارا - بروموانيلين والتي درس بعضا منها كمضادات للـ(HIV). وك | A new series of heterocyclic derivatives together with new biaryl analogues of biological interest have been synthesized starting from p - bromoaniline. Most of the new synthesized analogues have been tested for their anti - HIV (anti - human immunodeficiency virus - AIDS) activity.The thesis included the preparation of four types of compounds which have been use for further reactions as followings : 1. Preparation of the analogue R1 and its derivatives from treatment of p - bromoaniline with chloroacetylchloride. Reaction of R1 with KSCN or NH4SCN afforded the analogues R2 and R3 bearing benzothiazole backbone, respectively, while treatment of R1 with thiourea, hydrazine hydrate and piperazine gave R4, R5 and R7, respectively. In addition, treatment of R5 with p - toluenesulphonyl chloride (TsCl) yielded R6, meanwhile, fusion of R7 with maliec and phthalic anhydrides gave R8 and R9, respectively (Scheme 1).2. Preparation of the analogue R10 and its derivatives from treatment of p - bromoaniline with NH4SCN in the presence of bromine. Nucleophilic substitution of bromro residue of R10 by ( - SCN) group under microwave irradiation (MWI) afforded R11. Fusion of the latter with maliec, phthalicand succinic anhydrides gave R12, R13 and R14, respectively. In addition, treatment of R10 with p - cyanophenylboronic acid, via Suzuki coupling reaction and under MW, furnished the analogue R21(Scheme 2).3. Preparation of the analogue R15 and its derivatives,via diazotization reaction, from reaction of p - bromoaniline with acetylacetone. Treatmet of R15 with hydrazine hydrate or phenylhydrazine afforded R16 and R17, respectively.Furthermore, treatment of R17 with substituted arylboronic acids, via Suzuki coupling reaction and under MW, gave R23, R24 and R25 (Scheme 3).4. Preparation of the analogue R15 and its derivatives from treatment of p - bromoaniline with dimethylaminobenzaldehyde to give the azomethane derivative, which has been subjected to reflex with maliec and phthalic anhydrides by using ethanol to give the analogues R19 and R20, respectively. Additionally, treatment of R18 with substituted arylboronic acids, via Suzuki coupling reaction and under MWI, gave R27 and R28 (Scheme 4). The structures of the new synthesized analogues have been assigned from their 1H, 13C NMR and the C.H.N. analysis. In addition, most of the compounds have been identified from their 2D NMR : HSQC, HMBC, COSY and ROESY spectra.The thesis included the biological active study of the most new synthesized derivatives against Human Immunodeficiency Virus (HIV - 1 and HIV - 2) (AIDS), which carried out at Rega medical institute college of medicine, Katholiek University, Leuven, Belgium. The study showed that five analogues exhibited remarkable anti - HIV activity, since the analogues, R6, R8, R13, R26 and R28 showed EC50> (3.19, 2.11, 3.41, 2.31 and 3.72) µg/mL. In conclusion, compound R8 being the agent of choice for further pharmacological evaluation by its structural medication which might optimizeits potential activity to be drug in the future for treatment of AIDS.

اسم المؤلف: حسنى مهدي رياح الفتلي

اسم المشرف: ازهار عبد الامير سوسة

الموضوع العام: علوم الحياة

السنة: 2014

الموضوع الدقيق: النبات

الدرجة: دبلوم عالي

الجامعة: جامعة القادسية - كلية التربية - قسم علوم الحياة

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

استجابة نبات السلق (Beta vulgaris var. cilca L.) للشد الملحي وحامضي البرولين والجبرلين Response of Chard Plant (Beta Vulgaris Var. Cilca L.) To Salt Stress, Proline And Gibberellic Acids

اسم المؤلف: حيدر عبد الامير مظهور

اسم المشرف: انتصار حسين مهدي

الموضوع العام: علوم الحياة

السنة: 2014

الموضوع الدقيق: الحيوان

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم علوم الحياة

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: نفذت التجربة في الموسم الشتوي للعام (2012 - 2013) م في احد الحقول التابعة لناحية الحر في محافظة كربلاء, لمعرفة استجابة نبات السلق للشد الملحي والرش بحامضي البرولين والجبرلين والتداخل بينهما في بعض الصفات الكمية والنوعية لبعض الاجزاء الخضرية والتكاثرية (ا | An experiment was conducted in the winter season of the year (2012 - 2013) in a private Al - Hur district in Karbala governorate, to find out chard plant response to salt stress, proline and gibberellic acids and their interaction on some quantity and quality characteristics to some parts of vegetative and reproductive (leaves, flowers and seeds) to chard plant (Beta vulgaris var. cilca L.).The design of the experiment was randomized complete blocks (RCBD) in a factorial arrangement with three replicate. The first factor was four levels of saline water (0(River water), 2, 4 and 6) ds. m - 1 and the second factor was seven concentration of proline acid (PA) and gibberellic acid (GA3) (0(River water), 50PA, 100PA, 150PA, 50GA3, 100GA3 and 150GA3) mg. L - 1. Means were compared by using averages revised least significant difference (RLSD) at 0.05 probability level when the treatments referred to significant effect. The results showed : 1 - The negative effect of salinity levels on the qualities of the vegetative plant chard before flowering stage with the except of the dry weight of the root system, which had increased significantly with the level of salinity 2 ds. m - 1.2 - The negative impact of salinity levels in vegetative qualities of chard plant after flowering except root length, leaves chlorophyll content (a, b and total), nitrogen%, protein% and proline which increased with the level of salinity 2 ds. m - 1. as well as the potassium% in leaves with a salinity level 4 ds. m - 1 and dry weight of shoots with all levels of salinity and especially 6 ds. m - 1.3 - Gibberellic acid was dominant on proline acid in terms of chard plant by 150 mg. L - 1 concentration before flowering and 50 mg. L - 1. concentration after flowering while proline acid was dominant on gibberellic acid in dry weight before flowering and root dry weight of shoots after flowering, by 50 mg. L - 1 and potassium% in leaves and the protein% with 100 mg. L - 1 concentration.4 - The interaction between the salinity levels and acids concentrations add showed a significant difference in most of the traits of the plant, especially in combinations consisting of level 2 ds. m - 1 or comparison of saline with gibberellic acid by 150 mg. L - 1 before flowering and 50 or 100 mg. L - 1 after flowering while gave a combination of salinity level 4 ds. m - 1 with concentration of proline acid 100 mg. L - 1 higher of potassium% in leaves

تاثير المعاملة ببعض مبيدات الافات والمواد الكيمياوية في نمو الفطرين Alternaria tenuissima وFusarium oxysporum المرافقة لبذور وجذور الحنطة Triticum aestiumn Effect of Some Pesticides And Chemicals In The Growth of Fungi Alternaria Tenuissima And Fusarium Oxysporum Associated With The Seeds And Roots of Wheat (Triticum Aestiumn)

اسم المؤلف: مهند جاسم حمود

اسم المشرف: عبد الامير سمير سعدون

الموضوع العام: علوم الحياة

السنة: 2014

الموضوع الدقيق: الاحياء المجهرية - الفطريات

الدرجة: ماجستير

الجامعة: جامعة القادسية - كلية التربية - قسم علوم الحياة

اللغة: العربية

مكان الجامعة: القادسية

الصفحات الاولى:

المستخلص: اذ تم في هذه الدراسة عزل عدة انواع من الفطريات المرافقة لجذور وبذور الحنطة تموز 2 مصدق 1وتم تشخيص تسعة انواع من الفطريات المرافقة للبذور وبنسب تردد مختلفة وهذه الانواع هي Aspergillus niger, Penicillium notatum , Alternaria tenuissima, Rhizopus stotanifer | As it was in this study to isolate several types of fungi associated with the roots and seeds of wheat July 2 certified 1 was diagnosed nine types of fungi associated with seeds and different frequency rates and these types areAspergillus niger, Penicillium notatum, Alternaria tenuissima, Rhizopus stotanifer P. digitatum, Fusarium oxysporum, A.flavus, Fusarium solani, A. alternata. Was diagnosed nine types of fungi isolated from the roots of wheat and the surrounding soil and different frequency rates and these types. A. alternata, A. niger, R. stolanifer, Mucor sp., Trichoderma hazianum, P. notatum, F. oxysporum, F. solani, Alternaria tenuissima. Testing was diagnosed two fungal species tested using a technique monomer chain reaction PCR. These species are fungal Fusarium oxysporum, Alternaria tenuissima. This study tested the effect of pesticides is a fungal pesticide jungles Granstar and insecticide Wide. The transactions chemical which urea and NaCl in the growth of some fungi isolated from the seeds and roots of wheat as it has been test the effect of different treatments and their interaction in the germination of seeds of wheat on the filter paper and compare nets comparison innate Elsa (Carbendazim) and underwent tests the effects of different treatments and their interaction in radial growth and dry weight of the two types of fungi isolated in the germination of their spores and bacterial length of the tube, as well as test the effect of transactions and their interaction in the germination of seeds in the soil sterile and non - sterile. The results showed that the use of urea and sodium chloride concentration of 15 mg / mL in the treatment of seeds of wheat led to increased germination of these seeds and the impact of a negative in some types of pathogenic fungi associated with them as well as the use of pesticides other than fungal pesticide jungles Granstar and insecticide Wide negative effect also in the vitality Activity and fungi.germination The results showed the existence of significant effects on rates of seeds treated with pesticides and salts on the filter paper analogy transactions comparison since given concentration 15 mg / 10 mL of pesticides and 15 mg / ml of salt are high in the germination of the seed treatment, which exceeded ratios germination of seeds of wheat treatment urea fertilizer treatment fungicide Elsa. As rate ratios germination of wheat seed treatment with urea 96.66%, while the rate ratios germination of seeds of wheat pesticide Elsa 93.33%, followed by treatment of pesticide Wide as rate ratios germination 83.33% and 80.00% for wheat seed when the focus 15 mg / ml of sodium chloride salt treatment, and after treatment Karan Star as the rate of germination rates of seeds of wheat 73.33%. The results showed the existence of significant effects in increasing the proportion of seed germination treatment with pesticides and salts in the soil sterile and non - sterile as it gave the Focus 15 mg / 10 mL of pesticides and 15 mg / ml of salts highest rates of germination of these seeds came these results are compatible with the results of seed germination in the filter paper. The results show that as well as the individual transactions were more influential than the transactions overlap in radial growth and dry weight of fungi testers and their spores germination rates and lengths of germ tubes, as growth rates of radiographic Fungi F. oxysporum and A. tenuissima in the treatment of a mixture Wide and Granstar 11.44, 8.55 mm, respectively, while the rates of diameters of the colonies for the treatment of urea pesticide Wide 33.66 and 26.66 mm, while the pesticide mixture Wide treatment with sodium chloride amounted to 37.00 and 15.00 mm, in while rates were diameters of colonies for the treatment of a mixture Granstar with sodium chloride, 52.66 and 25.00 mm, and the growth rates were radiography for the treatment of pesticide Granstar with urea 25.00 and 11.66 mm, and the growth rates for the treatment of sodium chloride with urea 31.24 and 37.33 mm, compared with the fungicide Elsa, which amounted to the radial growth rates of 8.55 - 11.44 mm Fungi testers respectively.