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الاعراض السميه في الجهاز الهضمي نتيجة للعلاج الشعاعي الجذري في منطقة الحوض, الانواع, الشده والتواتر Acute Gastrointestinal radiation toxicities in pelvic radiation therapy; types, grade and frequency

اسم المؤلف: هديل ماجد علي رشيد
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • acute toxicities
  • radiation therapy
  • pelvic organ cancer.
الصفحات الاولى:
المستخلص: نوعية الحياة للناجين من السرطان قد تتضرربصورة مباشرة بسمية الامعاء؛ نتيجة للعلاج بالاشعاع في منطقة الحوض. 12000 مريض في المملكة المتحدة يعالج سنويا بالعلاج الاشعاعي الجذري لانواع الامراض السرطانية في منطقة الحوض؛ وهذا ينطوي على مخاطر كبيرة للاثار الجانبية للانسجة المحيطة العادي. الغرض من الدراسة الهدف من هذه الدراسة هو تحديد تواتر وانواع السمية المعدية المعوية الحادة في العلاج الاشعاعي الجذري لمنطقة الحوض في بلدنا وذلك ليمكننا من اجراء مقارنة مع الغرب في هذا الصدد, بطريقة تساعدنا في تطوير الاستراتيجيات الملائمة للوقاية والعلاج. المنهجية البحث عباره عن دراسه تحليليه مستقبليه, تم اجراءها في مركز العلاج النووي والعلاج الشعاعي/ مستشفى الاورام التعليمي في مجمع مدينة الطب في بغداد, من الاول من شهر كانون الثاني ولغاية الثلاثين من شهر نيسان لسنة 2016. الدراسه شملت 53 مريضا مؤكد بالزرع النسيجي مصابين بسرطان المثانة, الرحم، وسرطان عنق الرحم، والمستقيم، وسرطان البروستاتا، يتم علاجهم بالعلاج الاشعاعي الجذرية، التحقوا جميعا بالدراسة بعد موافقة عن علم وفقا لمعايير اشتمال واستبعاد. تم تقييم المرضى للتردد، وانواع ودرجة السمية المعدية المعوية الحادة وفقا لتصنيف معايير اثار الجانبية على اساس المنظمة الاوربية للبحوث والعلاج ولجنة معايير السمية مشتركة، في بداية، خلال وفي نهاية العلاج الشعاعي. وقد تم تحليل البيانات بواسطة برنامج البرمجيات "الحزمة الاحصائية" للعلوم الاجتماعية, اصدار 20).النتيجة من اصل 53 مريضا، 60.37% (n = 32) كانت انثى و39.62% (n = 21) من الذكور. سرطان بطانة الرحم تمثل 30.18% (n = 16) من الحالات، كانت سرطانات عنق الرحم 24.52% (ن = 13)، سرطان المستقيم 11.32% (n = 6)، سرطان المثانة 24.52% (ن = 13) وسرطان البروستاتا 9.43% (ن = 5) من مجموع الحالات. الاسهال لوحظ في 27 من اصل 53 مريضا(50.9%), 15 مريض كان يعاني من الالم (28.3%) بينما الامساك والغثيان والقي مثلوا (22.6%). كان معظم السميه متمثل بالمرحله الاولى ووجد فقط مريضان بوضع المرحله الثالثه (الاسهال 4.7%). الاستنتاج تواتر وشدة السمية الحادة في الجهاز الهضمي كانت ترتبط بزيادة جرعة الاشعاع، جنبا الى جنب مع استخدام العلاج الكيميائي, والتداخل الجراحي | Background : quality of life of cancer survivors is adversely impacted by bowel toxicity; result from pelvic radiation therapy. In the UK, 12000 patients are treated with radical radiation therapy for pelvic cancer, mostly with curative intent; this carries a considerable risk for normal surrounding tissues side effects.Objective : the aim of this study was to determine the frequency and types of acute gastrointestinal toxicity in radical pelvic radiation therapy in our patients so that a comparison could be made with the West in this aspect which would help us in developing appropriate strategies for its prevention and better management. Patients and Methods : a prospective analytic study was carried out in Radiotherapy department / Oncology teaching hospital / Medical city complex, from the 2nd of January to the 30th of April 2016.A total of 53 patients with histologically confirmed uterine, cervical, rectal, urinary bladder or prostatic cancer, treated by radical radiation therapy, were enrolled in the study after informed consent according to inclusion and exclusion criteria. Patients were assessed for the frequency, types and grade of acute gastrointestinal toxicities according to grading criteria of side effect based on RTOG (Radiation Therapy Oncology Group) /EORTC (European Organization for Research and Treatment) and CTC (Common Toxicities Criteria), at the start, during and at the end of the treatment. The data was analyzed by the Statistical Package for Social Sciences (SPSS, version 20) software.Result : Diarrhea occur in 27 out of 53 patients (50.9%), 15 patients had pain (28.3%) while constipation and nausea and vomiting were 22.6% (n=12/53) each. The majority had grade 1 toxicities and only 2 patients developed grade 3 diarrhea (4.7%).Conclusion : The frequency and severity of acute gastrointestinal radiation toxicities were associated with increase dose of radiation therapy, combined with the used of chemotherapy therapy and the presence of surgery.Background : quality of life of cancer survivors is adversely impacted by bowel toxicity; result from pelvic radiation therapy. In the UK, 12000 patients are treated with radical radiation therapy for pelvic cancer, mostly with curative intent; this carries a considerable risk for normal surrounding tissues side effects.Objective : the aim of this study was to determine the frequency and types of acute gastrointestinal toxicity in radical pelvic radiation therapy in our patients so that a comparison could be made with the West in this aspect which would help us in developing appropriate strategies for its prevention and better management. Patients and Methods : a prospective analytic study was carried out in Radiotherapy department / Oncology teaching hospital / Medical city complex, from the 2nd of January to the 30th of April 2016.A total of 53 patients with histologically confirmed uterine, cervical, rectal, urinary bladder or prostatic cancer, treated by radical radiation therapy, were enrolled in the study after informed consent according to inclusion and exclusion criteria. Patients were assessed for the frequency, types and grade of acute gastrointestinal toxicities according to grading criteria of side effect based on RTOG (Radiation Therapy Oncology Group) /EORTC (European Organization for Research and Treatment) and CTC (Common Toxicities Criteria), at the start, during and at the end of the treatment. The data was analyzed by the Statistical Package for Social Sciences (SPSS, version 20) software.Result : Diarrhea occur in 27 out of 53 patients (50.9%), 15 patients had pain (28.3%) while constipation and nausea and vomiting were 22.6% (n=12/53) each. The majority had grade 1 toxicities and only 2 patients developed grade 3 diarrhea (4.7%).Conclusion : The frequency and severity of acute gastrointestinal radiation toxicities were associated with increase dose of radiation therapy, combined with the used of chemotherapy therapy and the presence of surgery.

نوعية الحياة اثناء العلاج الشعاعي الخارجي للراس والرقبة Quality of Life During Head and Neck External Beam Radiotherapy

اسم المؤلف: علي غالب محمود
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: Worldwide, head and neck carcinoma is the sixth most common cancer accounting for 2.8% of all malignancies. Radiotherapy plays an integral role in their management and it is used in approximately 60 - 70% of cases. Even withrecent advancements in the radiation therapy it is still associated with certain treatment - induced reactions that may affect the quality of life of patients during and after treatment. This study aim to evaluate the radiation induced early side effects in patients receiving external beam radiotherapy for the treatment of a head and neck carcinoma.Patients and methods This study is an observational descriptive cross - sectional survey, with the target population being patients whom had external beam radiotherapy for a head and neck tumor whom are within 180 days from starting treatment. Forty patientswere included, all received external beam radiotherapy to the head and neck region at the Oncology Teaching Center / Radiation Therapy Department at the Medical City Complex with either a radical or adjuvant intent. The data were collected from 1st of January 2016 to 1st of March 2016. All patients were evaluated for the early side effects of external beam radiotherapy to the head and neck region including fatigue, skin dermatitis, voice changes, xerostomia, altered taste, oral mucositis, and dysphagia. As well as the incidence of patients who required a tracheostomy and/or a gastrostomy after initiation of radiotherapy, and that of those who developed a significant weight loss (>10% of their initial weight).ResultsIn this study, dysphagia occurred in 88% of the studied patients, only 1 patient (3%) developed a grade 4 dysphagia and required a gastrostomy. Of the 40 patients who were studied, 14 patients (35%) had a significant weight loss ≥10% of their initial weight. Xerostomia occurred in 85% of the studied patients, while fatigue occurred in 83% of the studied patients. Oral mucositis and skin dermatitis had similar incidences, each occurring in 63% of the studied patients.Voice changes and altered taste occurred in 55% and 53% of the studied patients respectively.ConclusionsDysphagia and xerostomia were the two most common early side effects of radiotherapy to the head and neck region. More than half of patients with dysphagia had a grade 2 or higher dysphagia, and about three - quarters of those with xerostomia had a grade 2 or higher xerostomia. To spare the salivary glands and pharynx during radiotherapy plan preparations as much as possible is highly recommended to reduce those two side effects.Although fatigue ranked third in incidence after dysphagia and xerostomia, the majority of those patients complained of only a mild fatigue over baseline.Skin dermatitis and oral mucositis had a similar incidence occurring in 63% of the studied patients. More than half of those patients had only a mild reaction (grade 2 or less). Regular use of soothing agents is recommended to counteract these two side effects.

تقييم الاضرار الجانبية المبكرة للعلاج الشعاعي في مرضى سرطان الثدي Assessment of early side effects of radiotherapy in breast cancer patients

اسم المؤلف: ايلاف علي حسين
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الكلمات الدلالية:
  • Breast cancer
  • Conventional fractionation
  • Hypofractionation
  • Radiation Dermatitis
الصفحات الاولى:
المستخلص: سرطان الثدي هو السرطان الاكثر شيوعا" عند النساء في العراق والعالم. العلاج الشعاعي يلعب دورا" اساسيا" في علاج سرطان الثدي. عند الممارسة العامة لعلاج الاورام بالاشعاع, سرطان الثدي نموذجيا" يشكل حوالي 25% من مجموع حالات المرضى.هذا يجعل فهم ماهية الضرر المتوقع من الاشعاع لسرطان الثدي وعلاجه ذو اهمية اولوية بما انه يؤثر على عدد قيم من المرضى يوميا".الاضرار الجانبية الناتجة عن الاشعاع في مرضى سرطان الثدي يمكن ان تنقسم الى اضرار جانبية مبكرة (حادة ومتوسطة) واخرى متاخرة. الاضرار الجانبية المبكرة تحدث خلال مدة المعالجة وحتى ستة اشهر بعد انتهاء العلاج.هذه الدراسة هي مسح استبياني ((cross - sectional survey مع مكونات تحليلية تهدف لتقييم الاضرار الجانبية المبكرة للعلاج الشعاعي الخارجي المساعد في 60 مريض بسرطان الثدي عولجوا في قسم العلاج الشعاعي في مستشفى الاورام والطب النووي في مدينة الطب من فترة كانون الثاني لنيسان 2016 بعد استئصال الثدي (44 مريض) او عمليات الحفاظ على الثدي (16 مريض).الاضرار الجانبية الناتجة عن الاشعاع الاكثر حدوثا" كانت تهيج جلدي 81.6%, ارهاق 70%, الم في المناطق المشععة 66.6%, حرقة البعوم 58.3%, غثيان 41.6%, صعوبة البلع 35% وتورم الذراع 28.3%.كان هناك فرق ذا قيمة احصائية بين حدوث التهيج الجلدي بين جرع الاشعاع الثلاث المستحدمة. تهيج الجلد الشديد (الدرجة الثانية والثالثة) كان حادثا"بصورة قيمة اكثر في المرضى المستلمين لجلسات الشعاع الاعتيادية (5000 cGy/25 F (CF)) منه في المرضى المستلمين لجلسات العلاج الشعاعي المختصرة (hypofractionation). وهذا متوافق مع المصادر.نسبة حدوث التهيج الجلدي كانت اكثر ايضا" في المرضى المعالجين بعمليات الحفاظ على الثدي 87.5% منها في الذين استاصلوا الثدي 79.5%, لكن العلاقة لم تكن ذات قيمة احصائية.استنتجنا ان هناك الكثير من الاضرار الجانبية الحادة تحدث بعد العلاج الشعاعي لمرضى سرطان الثدي ليس منها فوق الدرجة الثالثة. ولكنها تؤثر على جودة الحياة الصحية ويجب تجنبها ان امكن. تهيج الجلد كان اكثر اضرارالاشعاع الجانبية شيوعا وكان متعلقا بتقسيم الجرع. الارهاق كان الثاني وكان ذو صلة بمرحلة المرض. | Background : Breast cancer is the commonest cancer in women In Iraq and globally. Radiation plays an essential role in the management of breast cancer. In a general radiation oncology practice, breast cancer comprises approximately 25% of total patient caseload. This makes understanding what type of toxicity to expect from radiation for breast cancer and its management of prime importance since it affects significant numbers of patients daily. Radiation induced side effects (RISE) in breast cancer patients can be divided into early (acute and subacute) and late side effects. Early radiation toxicities occur during treatment time and up to six months after treatment has finished. Objectives : assessment of the early side effects of adjuvant external beam radiotherapy (EBRT) in breast cancer patients.Patients and Methods : A cross sectional survey with analytic component conducted on 60 patients treated in the radiotherapy department of oncology teaching hospital of medical city from the first of January to the 30th of April 2016 after mastectomy (44 patients) or breast conserving surgery (BCS) (16 patients).Results : The most prevalent RISE were radiation dermatitis (81.6%), fatigue (70%), pain in the irradiated area (66.6%), sore throat (58.3%), nausea (41.6%), dysphagia (35%), and arm edema (28.3%). There was a significant difference between prevalence of dermatitis with different radiation doses used. Dermatitis was more prevalent with conventional fractionation (CF), than in hypofractionated radiotherapy. The prevalence of dermatitis was also more in patient treated with BCS (87.5%) than those who had mastectomy (79.5%), but this relation was not statistically significant. Fatigue was found to be related to disease stage.Conclusion : Much acute toxicity were developed after radiotherapy to breast cancer patients, none of them was above grade 3; however they affect health related quality of life (HRQL) and should be avoided if possible. Dermatitis was the most common acute toxicity of radiotherapy in breast cancer patients. It was related to dose fractionation. Fatigue was the 2nd common. It was correlated with disease stage.

الحالة السريرية والمرضية النسيجية لمرضى سرطان الرئة في العراق وقت عرض الحالة Clinical And Pathological Profile Of Iraqi Lung Cancer Patients At Time Of Presentation (An Observation Study)

اسم المؤلف: هالة ساطع طه
اسم المشرف: منور عبد الاله النقاش
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: الخلفية العلمية : في جميع انحاء العالم يمثل سرطان الرئة 13% (1.6 مليون) من مجموع حالات السرطان و18% (1.4 مليون) من الوفيات الناجمة عن السرطان على اساس تقديرات عام 2008 وسرطان الرئة في العراق سبب شائع في للوفاة في كلا الجنسين اهداف الدراسة : التقييم السريري والتصويري للحالة المرضية وايجاد علاقة بين الانواع الفرعية النسيجية المرضية وغيرها من معلومات المريض .طريقة البحث : تعتبر هذه الدراسة من نوع دراسة المراقبة (دراسة مقطعية) تتكون من 60 مريض يعانون من مرض سرطان الرئة متوسطة اعمارهم 60 عام 38 ذكور و22 اناث (نسبة الذكور الى الاناث 1.7 : 1) تم جمع حالات المرضى من العيادة الاستشارية في مستشفى الاورام التعليمي في مدينة الطب من شهر كانون الثاني الى شهر نيسان 2016 تم تقييم جميع الحالات واجراء الفحص السريري والتشخيصي والنسيجي.النتيجة . تم دراسة (60) مريضا اثبتت اصابتهم بسرطان الرئة سن الحد الادنى للمرضى هو 32 سنة والحد الاقصى 81 سنة بمتوسط عمر 60 عام 38 من الذكور و22 اناث معظم المرضى لديهم صعوبة التنفس في وقت العرض (21%)، ونفث الدم (20%). تليها السعال (16 %). اما المكان التشريحي الاكثر اصابة بسرطان الرئة الفص العلوي الايمن 14 (23%). ثم الفص العلوي الايسر 9 (15%). يعد الغسل القصبي اختبار الخلايا 22 (36%) اكثر وسيلة مستخدمة لتشخيص المرض يليها فحص الخلايا المسحوبة بواسطة الابرة الناعمة 9 (15 %)، طموح السائل الجنبي 8(13.3%) الخزعة الاستئصالية 7 (11.7%)، الخزعة الجراحية 5 (8.3%)، علم خلايا البلغم 4(6.7%)، الخزعة الماخوذة بمساعدة الجهازالطبقي المقطعي 2 (3.3%) النتيجة التشريحيةالمرضية الرئيسية هي سرطان الخلية الحرشفية (41.7%) ثم الغدية (36.7%) بعدها سرطان الرئة صغير الخلية ، ورم الظهارة المتوسطة (8.3%) اخيرا يمثل سرطان الخلايا القشرية هو الشائع في الذكور 20(52.6%) ولكنه في الاناث 5 (22.7%) ومع ذلك السرطانات الغدية هي الاكثر شيوعا في الاناث 12 (54.5%) من الذكور 10 (26.3%) هنالك علاقة طردية بين نسبة حدوث سرطان الرئة من نوع الخلايا الصغيرة مع التدخين حيث ان جميع المرضى هم مدخنين بينما في الخلايا الحرشفية فان (47.8%) هم مدخنين (P=0.003) اغلب المرضى لديهم ورم خبيث منتشر وقت تشخيص الحالة (56%) و(33.3%) لديهم استسقاء رئويالاستنتاجات : 1 - اكثر عارض مرضي يعاني منه مرضى السرطان في العراق هو ضيق التنفس ثم النفث الدموي.2 - الفص العلوي الايمن هو الاكثر اصابة بالمرض 3 - الغسل القصبي وفحص الخلايا هو اكثر طرق التشخيص شيوعا 4 - سرطان الخلايا الحرشفية هو النوع النسيجي المرضي السائد في الذكور بينما سرطان الرئة من نوع الغدي هو السائد في الاناث 5 - هناك علاقة ذات دلالة احصائية بين سرطان الخلايا الحرشفية والتدخين (P=0.003) واغلب المرضى يعانو من مراحل متقدمة في وقت عرض الحالة | Background; Carcinoma of the lung is currently the leading cause world wide of death . The disease has become an epidemic as incidence rates and lung cancer deaths have risen dramatically over the last century, Throughout the world, lung cancer accounts for 13% (1.6 million) of the total cases of cancer and 18% (1.4 million) of the cancer - related deaths based on 2008 estimates. Among males, lung cancer is the most commonly diagnosed cancer and leading cause of cancer death. Among females worldwide, it is the fourth most commonly diagnosed cancer and the second leading cause of cancer death.Aim of study : 1 - Identify the most common stages of lung cancer at time of presentation2 - Estimate the anatomical distribution of lung cancer according to histopathological subtypes3 - Find the acorrelation between histopathological subtypesAnd other parameters of patient profilePatients &Methods : Methods;An observation study ( A cross sectional study) of 60 patients with lung cancer with mean age of 60 years old.38 male;22 female (male : female 1.7 : 1). cases were collected from consultant clinic at the Oncology Teaching Center in Medical City. The data were collected from 1st January to 30th of April/2016. All patients were evaluated from history ,physical examination ,sent for investigations &review of histopathology samples.Results : A total of 60 lung cancer patients were studied,mean age of patients 60 yrs old , male : female ratio 1.7 : 1 ,most patients are smoker, Sequamous cell carcinoma is commonest type (41.9% ) of all patients, and its male predominant (33.3%) .Most patient diagnosed by bronchial wash and cytology (36%) ,Right upper zone is commonest site of malignancy (23.3%) ,most patients presented in advance stage and metastasis (56%).Conclusions*Lung cancer is commonest cause of cancer related death.*Proper stage of disease is recommended as mediastinscopy found 15% of occult lymph node metastasis in radiologically normal nodes.*Most patients have metastasis at time of presentation so we can use new radiological modalitiy to diagnosed occult metastasis.*use molecular biology to proper diagnose the histopathologiac subtypes and identify the response to treatment and give a prognosis idea*Active surveillance of primary small lung lesion

تصنيف المرضى العراقيين المصابين بالاورام العصبيه الغديه وتقدير مدى استجابتهم لعقارالساندوستاتين (الاوكتيريوتايد) NEUROENDOCRINE TUMORS CLASSIFICATION AND RESPONSE TO LONG ACTING SOMATOSTATIN ANALOGUE; AN IRAQI EXPERIENCE

اسم المؤلف: مروة خالد عبد الفتاح
اسم المشرف: منور عبد الاله النقاش
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: The lack of studies regarding the incidence of neuroendocrine tumors (NETs) is related to the rarity of these tumors (25/1,000,000). Chromogranin A is a useful tumor marker for NETs diagnosis & follow - up. Octereotide LAR is an established treatment for NETs by both providing symptomatic relief & inhibiting tumor growth. However, studies regarding incidence of NETs & their response to SAS - LAR are still insufficient.Aim of studyTo shade the light on the incidence of NETs, the clinico - pathologic characteristics of Iraqi patients with NETs & their response to long acting Octereotide.Patients & methodsThis is a cross - sectional observational study that was conducted in Oncology teaching hospital/medical city complex using patients’ follow - up sheets. Data recruitment included all NET patients diagnosed after October 2013 to April 2016.ResultsIn our registry, 38 patients were recorded; most patients (60.5%) were over the age of 50 years with male to female ratio (1.2 : 1). We found the gastroenteropancreatic tract being the most common primary organ followed by pelvis . With respect to the GI tract we found that pancreas (26.3 %) was the commonest primary organ. Metastatic disease at presentation was found in (44.7%) of patients with the Liver (15.8%)was the most common metastatic site.Notably, most of our patients presented with G3 disease (44.7%) & (13.2%) with G1 . Serial CgA tests were performed in (17/28) patients used SAS - LAR, with a change in mean value from (225.3 U/L) pre - using the agent to (17.5 U/L) two months after use & to (8.7 U/L) four months after use(p=0.001) while the change in mean of CgA level was from (205.9 U/L) to (200.9 U/L) in 10 patients who did not use octereotide.(p=0.2). After a period of 2 years ,the median time of remission following SAS - LAR administration was 3 months compared to 7 months in patients received other modalities of treatment. In our study, a statistically significant difference was demonstrated between the two groups of patients.(p=0.003).Conclusion Plasma CgA is the most reliable marker for NETs, reflecting the clinical evolution of the disease. Aids in diagnosis & response assessment to different therapies.Octreotide LAR provides symptomatic response & contributes to disease stabilization & tumor regression in both functional & non functional NETs.1 - INTRODUCTION Neuroendocrine tumors are thought to arise from cells throughout the diffuse neuroendocrine system that is composed of peptide - and amine - producing cells that may secrete different hormones depending on the site of origin. NETs are composed of monotonous sheets of small round blue cells with uniform nuclei and cytoplasm(1). They compromise a broad family of tumors, the most common of which are carcinoid tumors (most commonly arise in the lungs & bronchi, small intestine, appendix rectum, or thymus)& pancreatic NETOther neuroendocrine tumors arise from parathyroid, adrenal, pituitary gland, & in calcitonin - producing cells of the thyroid (causing medullary thyroid carcinoma)( 2).Most NETs seem to be sporadic; risk factors for sporadic NET are poorly understood. Risk factors for the development of midgut carcinoid tumors include age, male sex, and increased body mass index, and menopausal hormone therapy (1).NET may also arise in the context of inherited genetic syndromes, include multiple endocrine neoplasia (MEN) types 1& 2 (2).The incidence of gastrointestinal (GI) NETs is 6.2 per 100,000 populations and has been steadily increasing. The increasing incidence of NETs reportedIn many studies is likely multifactorial and includes increased awareness and improved endoscopic methods of detection.As these tumors are indolent and patients survive a long time, the prevalence is quite high, making them the second most prevalent GI tract tumor, second only to colon cancer. Some are clinically silent and have been detected only at autopsy (incidence 8%). Further ,patients with GI NETs have a higher risk of other noncarcinoid primary tumors. The overall 5 - year survival rate of all patients with GI NETs is 28.5%.(1) Of all NETs ∼25% are located in the respiratory tract. Typical carcinoids (TCs) comprise ∼1% - 2% and atypical carcinoids (ACs) only 0.1% - 0.2% of pulmonary neoplasms. According to the surveillance, epidemiology and end results program (SEER) database from 2003, the combined incidence has been 1.57/100 000 inhabitants . The prevalence of thymic NET is ∼3% of the total number of NETs at all sites. In the last SEER database, a reported incidence of thymic NETs is 0.02/100 000 population per year . They constitute ∼5% of all thymic tumors. Both bronchial and thymic NETs may be part of multiple endocrine neoplasia type 1 syndrome (MEN - 1, 5% - 15%). The median age at diagnosis for bronchial NETs is 64 years and for thymic NETs 59 years.(3) The incidence of G1NET increased from 2.0 to 3.0; there was a large increase in G2NET from 0.01 in 1990 to 0.2 in 2010, and of the G3 - LCNET from 0.01 to 1.8, respectively. In G3 - SCNET incidence in men decreased from 21.3 to 10.1, whereas in women it increased from 4.5 to 7.7.(4).

عوامل الخطورة وتصنيــف اورام الرحــم وتدريجاتـه Risk factors and histopathological types of uterine cancer 2016

اسم المؤلف: رشا زكــــي شكــــــر
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: سرطان الرحم نسبيا يعتبر من الاورام الشائعه بين النساء حيث انه ياتي في المرتبه الرابعه بين الاورام الخبيثه التي تصيب النساء خاصة النوع الشبيه ببطانة الرحم.ان التصنيف حسب التشريح النسيجي المرضي ومرحلة الورم وعوامل الخطوره للمرض لم يتم تقييمها بصوره جيده في النساء العراقيات من اللواتي اصبن بهذا المرض.الغرض من الدراسةان الغرض من هذه الدراسة هو لمعرفة نوع الورم حسب التشريح النسيجي المرضي ومرحلة المرض عند تشخيص المرض وعوامل الخطوره للمرض بين المريضات العراقيات المرضى وطرق البحثتشمل هذه الدراسة خمسه واربعون مريضة مصابة بسرطان الرحم من مراجعات مستشفى الاورام التعليمي في مدينة الطب في بغداد للفترة من شهر كانون الثاني لغاية شهر نيسان 2016.لقد تم جمع المعلومات الضروريه من خلال الاستبيان المعد مسبقا من قبل فريق البحث وقد تم جمع المعلومات المطلوبه من فايلات المرضى المراجعين لمستشفى الاورام التعليمي في مدينة الطبالنتائجفي هذه الدراسة كانت 77.8% مريضة بعمر اكثر من 50 سنة ,86.7% من المريضات كان لديهن تاريخ احاظه مبكره,86.7% من المريضات كن في مرحلة سن الياس.كانت هناك نسبه قليله من المريضات ممن كان لدين تاريخ دوائي باستخدام الهورمونات او عدم الانجاب او وجود تاريخ مرضي للمرض في العائله وان نسبة 51% كن في المرحله الاولى من المرض اثناء تشخيص المرض ابتدائيا | Uterine cancer is relatively common; it’s the fourth most common malignancy in women. Histopathological types, staging and risk factors for uterine cancer are not yet well evaluated in Iraqi patients with uterine malignancy.Aim of study : - To classify uterine carcinoma patients according to histopathological type, risk factors and stageing.Patients and method : Cross - sectional study was conducted for 45 patients in Oncology Teaching Hospital, Medical city, Baghdad, Iraq between Jan.1st - April 1st2016. The data were collected from the medical records of patients with uterine cancer who’s attending to the hospital for completion of treatment through questionnaire which was developed by research team.Results : - The results of this current study on total of 45 patients showed that 77.8% 35 patients were older than 50 years, 86.7% 39 patients with history of early menarche, 86.7% 39 patients were in post - menopause phase, 33.3% of patients had history of hormonal therapy, infertility and family history of the disease. Endometrioid and Papillary serous types represented the highest percentage (42.2%, 28.9%) respectively. Highest percentages (51%) of patients were in stage one at the time of diagnosis.Recommendation : - - Further studies on uterine tumor. - Early detection programs should be activated. - Close follow up on patients from Stage 1. - Awareness programs on risk factors should be activated. - Patients educational sessions should be conducted regularly in the Hospitals.

معالجة اورام الدماغ في العراق 2016 Management of brain Tumors in Iraq 2016

اسم المؤلف: هدير رياض سعيد
اسم المشرف: خضير جاسم صبيح الرواق
الموضوع العام: الطب
السنة: 2016
الموضوع الدقيق: الاشعة العلاجية
الدرجة: دبلوم عالي
اللغة: الانكليزية
مكان الجامعة: بغداد
الصفحات الاولى:
المستخلص: CNS tumors constitute 2% of all cancers, and are observed in 4 - 5 in 100,000. CNS tumors exhibit different behaviors according to age, histology, and location.Aim of study1 - Detect the rate of incidence of CNS tumors in relation to age, sex, geographical distribution, environmental factors & genetic factors in our country2 - Explaining of the associated clinical features3 - Determine the effect of radiotherapy & chemotherapy on the patient’s outcome.Patients and methodsProspective study of CNS tumors started from the beginning of Jan 2016 to the end of Apr 2016. The patients were taken from the outpatient clinic of Oncology Teaching Hospital / Medical City in BaghdadAll patients (47) underwent surgery and the surgeons then sent them to our out patients clinic with their Histopathological reports seeking for further management.(42) Patients received Chemotherapy and/or Radiotherapy while the remaining (5) patients didn’t followed up after surgery because they didn’t attend to our out patients clinic according to their dates.The outcome of management was divided into : Good outcome, Fair outcome and Poor outcome.ResultsThe 5th decade is the most commonly involved age with male incidence more than females and the incidence is higher in the south of Iraq. There is little IIassociation of CNS tumors with family history and high association with environmental factors. Neurological deficit was the main chief compliant and headache was present in most of the patients at time of diagnosis. Frontal region was the commonest site for CNS tumors with size of 1 - 5cm and mostly associated with edema and +ve enhancement. Meningioma was the commonest histological type.Conclusions1 - There is a poor relationship between family history & CNS tumors2 - There is significant relationship between environmental factors & CNS tumors.3 - Headache is not the dominant chief compliant in compare with neurological deficit .4 - Total resection of the tumor followed by radio and/or chemotherapy has the best prognosis.Recommendations1 - Further researches with larger sample size to be collected from all oncology hospitals in Iraq are needed to generalize the results to national level .2 - Make the total resection of the brain tumor the aim of the surgeon because it is the golden stone in brain tumor management.3 - Use the new technique of radiotherapy like gamma knife and IMRT for the