Author name: مثنى سعيد علي كريم

Supervisor name: سهام توفيق امين | عبد الرحمن خضيرعبد الحسين الطائي

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Master

University: Tikrit University - Faculty Of Education - Chemistry Department

Language: Arabic

Full text from the source: https://basicedu.uodiyala.edu.iq/uploads/work%202018/science%20dept/%D8%B1%D8%B3%D8%A7%D8%A6%D9%84%20%D8%A7%D9%84%D9%85%D8%A7%D8%AC%D8%B3%D8%AA%D9%8A%D8%B1/%D8%B1%D8%B3%D8%A7%D9%84%D8%A9%20%D9%85%D8%AB%D9%86%D9%89%20%D8%B3%D8%B9%D9%8A%D8%AF.pdf

University location: Salahaddin

First pages:

Abstract: الدراسة تتضمن ثلاثة خطوات : - الخطوة الاولى : _ تحضير قواعد شيف (H1 - H15) التي تحتوي على موقع بارامع رسم المجموعات تحتوي على التحضيرات على التوالي في وسط متعادل خلال التفاعل بين مركبات الامينات الاروماتية ومعوضات البنزلديهايد في الايثانول المطلق. الخطوة | First step Schiff bases [H1 - 15] containing Para donating and with drawing groups have been prepared respectively in a neutral medium, through the reaction between aromatic amines compounds and substituted enz aldehyde in absolute ethanol. Second steppreparation of some of heterocyclic compounds include 3 - chloro - 2 - oxo - zetidine - 2 - one (H16 - 30) through its rection with chloro acetyl chloride in presence of tri ethyl amine in 1,4 - Dioxan and2 - (substituted aryl)thiozoldin - 4 - one (H31 - 40) is prepared from the reaction of thioglycolic acid with Schiff bases in presence of zinc chloride in dry Benzene and2 - (sub.aryl) - 5,7 - di - one oxazipene (H41 - 50) are synthesized by cyclization of Schiff bases using malic anhydride in methanol.Third stepthis part of the research included the preparation of compounds similar to chalcones which are the phenyl propene amide derivatives by the condensation of acetanilide and substituted acetanilide with substituted benzadehydes The phenyl propene amide derivatives were reacted with hydrazaid(iso nazaid) is preparation of Pyrazoline compounds (H56 - 60) are synthesized from the reaction of chalcons (H50 - 55).The structures of the synthesized compounds were supported by means of (FTIR), (UV - Vis), (1H - NMR) and the results are agreement with the proposed structures assigned to the synthesized compounds. Study of the biological activity for prepared compounds The study also includes the biological activity for some of the prepared compounds against four kinds of germs which known by its resistance against antibiotics, these are the compounds (H18,H31,H35,H41,H42,H53,H5) are tested on four types of germs which cause illness and resist the antibiotic agents and these germs( Bacillus submits, E - coli, salmonella, Enter course)and study the biological activity for some of the activity using different concentration and different type of fungous The results showed prominent activity against these bacteria, the detailed antibacterial screening are reported in Table (15) and the Inhibition of the fungus screening are reported in Table (16).

التقدير الطيفي للترايفلوبيرازين والكلوربرومازين في المستحضرات الصيدلانية باستخدام تفاعلات الاكسدة == Spectrophotometric Determination of Trifluoperazine Hydrochloride And Chlorpromazine Hydrochloride In Pharmaceutical Formulation By Oxidation Reactions

Author name: عمر عدنان هاشم شريف ال ابليش

Supervisor name: علي ابراهيم خليل الجبوري | محسن حمزة بكر

General topic: Chemistry

Specific topic: Chemistry

Degree: Master

University: Tikrit University - Faculty Of Education - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: This study contained ageneral introduction about the Ion - Selective electrodes and ageneral introduction about Schiff's Base and the determination of Diphenhydramine Hydrochloride (DPH) and Phenylephrine Hydrochloride (PEH) and Metoclopramide Hydrochloride (METO) and Metformin Hydrochloride (METF ) drugs using new methods applying potentiometric (the first part) and using Schiff's Base as ionophor In ISES membranes ( the second part).The first part includes construction of membrane selective electrodes for DPH and PEH drugs based on complexation of drugs with Ammonium Reinckate (AR) and Phospho Molybdic acid (PMA) as an active substance using Di - n - Butyl phthalate (DBPH) as a plasticizers , poly vinyl chloride was used as a matrix for all electrodes.The Characters of each electrode were as follow : 1. For the Diphenhydramine - Ammonium Reinckate (DP - AR) electrode using (DBPH) as a plasticizers, the optimum condition were (4.5 - 6.5), (20 - 30?C), 10 - 2 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29.40) mv/decade, correlation coefficient r= 0.9971, detection limit (8.88x10 - 7 M) and life time of the electrode was 34 days.2. For the Diphenhydramine - Phospho Molybdic acid (DP - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (4.5 - 6.5), (20 - 30 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 90) mv/decade, correlation coefficient r= 0.9960, detection limit (6.8x10 - 8 M )and life time of the electrode was 40 days.3. For the Phenylephrine - Ammonium Reinckate (PE - AR) electrode using (DBPH) as a plasticizers, the optimum condition were (5 - 6), (25 - 30 ?C), 10 - 3 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29.8) mv/decade, correlation coefficient r= 0.9990, detection limit (2.22x10 - 7 M) and life time of the electrode was 24 days.4. For the Phenylephrine - Phospho Molybdic acid (PE - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (5 - 6), (25 - 30 ?C), 10 - 3 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29.5mv\decade), correlation coefficient r= 0.9990, detection limit (4.87x10 - 7 M ) and life time of the electrode was 26 days.The second part includes the use of Schiff's Base as ionophor in ISES MembranesThe second part includes construction of membrane selective electrodes for METO and METF drugs based on complexation of drugs Schiff METO and Schiff METF as Ionophor with Phospho Molybdic acid (PMA) as an active substance using Nitro benzene (NB) and Di - n - Butyl phthalate (DBPH) as a plasticizers , poly vinyl chloride was used as a matrix for all electrodes.The Characters of each electrode were as follow : 1.For the Metoclopramide - Phospho Molybdic acid (Schiff’s METO - PMA) electrode using (NB) as a plasticizers, the optimum condition were (4 - 6), (20 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (19.90) mv/decade, correlation coefficient r= 0.9970, detection limit (4.5x10 - 7 M) and life time of the electrode was 122 days.2.For the Metoclopramide - Phospho Molybdic acid (Schiff’s METO - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (4 - 6), (20 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively. The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 70) mv/decade, correlation coefficient r= 0.9950, detection limit (3.83x10 - 7 M )and life time of the electrode was 108 days.3.For the Metformin - Phospho Molybdic acid (Schiff’s METF - PMA) electrode using (NB) as a plasticizers, the optimum condition were (5 - 6), (25 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 30) mv/decade, correlation coefficient r= 0.9970, detection limit (3.87x10 - 7M )and life time of the electrode was 102 days.4.For the Metformin - Phospho Molybdic acid (Schiff’s METF - PMA) electrode using (DBPH) as a plasticizers, the optimum condition were (5 - 6), (25 - 35 ?C), 10 - 4 M for pH , temperature and concentration of filling solution respectively.The linear concentration range was from (10 - 5 - 10 - 1) M with a slope of (29. 10) mv/decade, correlation coefficient r= 0.9980, detection limit (2.37x10 - 7 M )and life time of the electrode was 90 days

دراسة مستوى انزيم الرينيين والفا - ل - فيوكوز وبعض المتغيرات الكيموحيوية للمرضى المصابين بالعجز الكلوي المزمن == Level of Renin Enzyme, ? - L - Fucose And Some Biochemical Markers For Chronic Renal Failure Patients

Author name: سروت بهرام عارف محمود الكاكةئي

Supervisor name: صباح حسين خورشيد

General topic: Chemistry

Specific topic: Biochemistry

Degree: Doctorate

University: Tikrit University - College Of Education For Pure Sciences - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: خلفيه البحث : سوفان المفاصل هو مرض مزمن يؤدي الى حدوث تغيرات ضارة في الغضاريف والعظام والاربطة والعضلات , علما ان وصف المرض بشكل دقيق غير محدد لحد الان. والسؤال المطروح عن العلاقة بين العلامات الناتجة عن هذا المرض وتلك الناتجة عن مرض السكري, هل الام السك | خلفيه البحث : سوفان المفاصل هو مرض مزمن يؤدي الى حدوث تغيرات ضارة في الغضاريف والعظام والاربطة والعضلات , علما ان وصف المرض بشكل دقيق غير محدد لحد الان. والسؤال المطروح عن العلاقة بين العلامات الناتجة عن هذا المرض وتلك الناتجة عن مرض السكري, هل الام السكري تخفي الام المفاصل ؟ حيث ان كلا المرضين(السكري والمفاصل) هما من الامراض المزمنة وتتصف بمستويات غير واضحة من التغيرات البايولوجية للمريض.الهدف من البحث : صممت هذه الدراسة لايجاد العلاقة بين داء السكري وسوفان المفاصل من خلال دراسة بعض المتغيرات الحياتية المشتركة بين المرضين مثل الفسفاتين واللبتين وهرمون النمو المشابه للانسولين... , وايضا دراسة تاثير داء السكري على تطور سوفان المفاصل. العينات, المواد وطرائق العمل : تضمنت هذه الدراسة (88)عينة مرضية من النساء فقط تراوحت اعمارهم (40 - 60) سنه ,في بداية التشخيص لمرض سوفان المفاصل من المصابين وغير المصابين بداء السكري الذين يعانون من السمنه)وقد تم جمع العينات من مستشفى الكاظمية التعليمي والمركز الوطني لبحوث وعلاج السكري / مستشفى اليرموك,من شهر ايار - تشرين الاول(2013 ) وقد تم تقسيم عينات المرضى الى ثلاث مجاميع وهي( مجموعة سوفان المفاصل وعددهم 24)و(مجموعة داء السكري وعددهم 20عينه)و(المجموعة الحاملة كلا المرضين عددهم 24عينه) فضلا عن مجموعة السيطرة وعددهم (20عينه) وقد تم تقدير مستويات الدوال في امصال العينات من خلال اجراء الفحوصات المختبرية التالية : هرمون الفس?اتين, هرمون االلبتين, هرمون النمو الشبيه بالانسولين - 1,مستوى الانسولين الصائم , هرمون المناسل المحفز الجربي FSH والمحفز للجسم الاصفر LH , مؤشر معصد البلازما بوساطه العلاقة اللوغاريتمية المتمثلة بالكسر المولي للدهون الثلاثية والدهون عالية الكثافة وفحص مقاومه الانسولين,وفحص السكر الصائم, الدهون في الدم وخضاب الدم المعسل والتي تم قياسها لجميع المرضى وافراد مجموعة السيطرة.النتائج : كانت النتائج المستحصلة من هذه الدراسة كما يلي : ? اظهر المستوى االمصلي للفسفاتين واللبتين وكذلك قيم مؤشر معصد البلازما زياده معنويه في مجاميع المرضى الثلاث وهي (داء السكري , سوفان المفاصل والذين يعانون كلا المرضين) بمجموعه السيطرة بمستوى احتماليه p< 0.05)),في حين لوحظ انخفاض معنوي لدى المرضى الذين يعانون من كلا المرضين (السكري والسوفان) في حالة اخذ الدواء مقارنة بالمرضى بدون دواء تحت احتماليه p< 0.05)).? اظهر المستوى المصلي لهرمون النمو الشبيه بالانسولين انخفاض معنوي في مجاميع المرضى الثلاث وهي (داء السكري , سوفان المفاصل والذين يعانون كلا المرضين) بمجموعه السيطرة تحت احتماليه p< 0.05)), في حين لوحظت زيادة معنوية لدى المرضى الذين يعانون من كلا المرضين (السكري والسوفان) في حالة اخذ الدواء مقارنة بالمرضى بدون دواء تحت احتماليه p< 0.05)), ووجد ايضا ان عامل العمر له تاثير " كبير جدا على قيم مؤشر معصد البلازما ومستوى الفسفاتين ,اللبتين وهرمون النمو الشبيه بالانسولين.? اظهر انخفاض معنوي في مستوى نسبة LH/ FSH في مجاميع المرضى الثلاث وهي (داء السكري , سوفان المفاصل والذين يعانون كلا المرضين) بمجموعه السيطرة تحت احتماليه p< 0.05)), في حين وجدت زياده معنوية في مستوى نسبة LH/FSH في مجموعة المرضى اللذين يعانون من كلا المرضين مقارنة بمجموعة مرضى السكري ومجموعة سوفان المفاصل ولوحدها. ? مستوى الفسفاتين يرتبط ايجابيا مع قيم مؤشر معصد البلازما في مجموعة مرضى داء السكري والمجموعة اللذين يعانون كلا المرضين تحت احتماليه p< 0.01)),في حين لايوجد ارتباط بين مستوى الفسفاتين وقيم مؤشر معصد البلازما في مجموعة مرضى سوفان المفاصل ومجموعة السيطرة. ? اظهر مستوى هرمون النمو الشبيه بالانسولين ارتباطا سلبيا مع قيم مؤشر معصد البلازما عند مجاميع المرضى الثلاثة ( داء السكري , سوفان المفاصل وكلا المرضين) تحت احتماليه p< 0.01)), لكن لايوجد ارتباط مع مجموعة السيطرة. ? اظهر مستوى اللبتين ارتباطا ايجابيا مع قيم مؤشر معصد البلازما عند مجاميع المرضى الثلاث ( داء السكري , سوفان المفاصل وكلا المرضين) تحت احتماليه p< 0.01)), لكن لايوجد ارتباط مع مجموعة السيطرة.? وايضا وجد ارتباط سلبي بين مستوى الفسفاتين ومستوى اللبتين عند المجموعة الحاملة كلا المرضين داء السكري وسوفان المفاصل تحت احتماليه p< 0.01)),في حين كان هناك ارتباطا ايجابيا بين مستوى الفسفاتين ومستوى اللبتين عند مجموعة السكري ومجموعة سوفان المفاصل ولوحدها تحت احتماليه p< 0.01)), وقد وجد ايضا ارتباطا سلبيا بين مستوى الفسفاتين ومستوى هرمون النموالشبيه بالانسولين عند مجاميع المرضى الثلاث تحت احتماليه p< 0.01)) , ولايوجد ارتباط مع مجموعة السيطرة. ? اظهر ارتباطا ايجابيا بين مستوى نسبة LH/FSH وكل من مستوى الفسفاتين , اللبتين وهرمون النمو الشبيه بالانسولين عند مجاميع المرضى الثلاث تحت احتماليه p< 0.01)), لكن لايوجد ارتباط في مجموعة السيطرة. الاستنتاج : نستنتج ان سوفان المفاصل له تاثير مباشر على بعض المؤشرات الحياتية مثل مستويات هرموني اللبتين والفسفاتين واختلال الدهون وقيم مؤشر معصد البلازما. ومن اهم النتائج ان الفسفاتين مؤشر جيد لدراسة تطور المرض ومن الممكن استخدامه كوسيلة للعلاج وكذلك نستنتج ان السيطرة على مستويات السكر عند مرضى سوفان المفاصل مهم جدا خلال العلاج وبالاخص لو تطلب الامر اجراء عملية جراحية.

تحضير، تشخيص وتقييم بايولوجي لبعض الادوية المصاحبة المشتقة من بعض مضادات الالتهابات غير الستيرويدية == Synthesis , Characterization And Biological Evaluation of Some Prodrugs Derived From Non - Steroidal Anti - Inflammatory Drugs (NSAID's)

Author name: مصطفى راجي عايد حمد

Supervisor name: خالد مطني محمد الجنابي | اياد سعدي حميد الدليمي

General topic: Chemistry

Specific topic: Biochemistry

Degree: Master

University: Tikrit University - Faculty Of Education - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: اجري هذا البحث لايجاد العلاقة بين العجز الكلوي المزمن ومستويات بعض المتغيرات الكيموحيوية عن طريق قياس مستوى انزيم الرينيين والفيوكوز الكلي (TF), الفيوكوز المرتبط بالبروتين (PBF) , البروتين المرتبطة بالسكريات السداسية (PBHex) وعدد من المتغيرات الكيموحيوية | This study has been done to determine the relationship between chronic renal failure and the level of some biochemical parameters (Rennin enzyme, Total Fucose(TF), Protein bound Fucose(PBF), protein bound Hexose (PBHex), and some other biochemical parameters including glucose , Urea, createnine, Uric acid, High density lipoproteins Cholestrol(HDL - c.), low density lipoproteins Cholestrol (LDL - c.) and electrolytes (Na+, K+ and Ca+2). Case study included (80) patients with chronic renal failure,Who admitted to the Kirkuk General Hospital Department of Dialysis , there ages were (31 - 60 years) of both sexes , patients has been divided into subgroups according to age {(31 - 35),(36 - 40),(41 - 45),(46 - 50),(51 - 550),(56 - 60)}year and severity compared with (45) normal persons as control with same ages, the results was as follows : Results showed a significant increase (P?0.01) in the level of rennin enzyme (5.013±0.052 ng/mL.h) of patients before dialysis compared with control group (2.58±0.32 ng/mL.h) for different age groups, and there was a significant increase slightly for different age groups.There was a significant increase (P?0.01) in the level of TF and PBF (12.14±0.89 mg/dL),(7.450±0.18 mg/dL) respectively compared with control group (28.76±0.03 mg/dL), (2.26±0.27 mg/dL) respectively for different age groups, and there was no significant correlation between age groups or sex.There was significant decrease (P?0.01) in the level of protein bound hexose PBHex, (123.35±0.9 mg/dL) compared with control group (89.76±0.9 mg/dl) for different age groups, and there was no significant correlation between age groups or sex.There was a significant increase (P?0.01) in the level of glucose (5.072±0.13 mmol/L) compared with control group (7.03±0.46 mmol/L) for different age groups, and there was a significant increase for females (7.40±0.7 mmol/L) compared with males (6.84±0.4 mmol/L).There was a significant increase (P?0.01) in the level of urea, uric acid and createnine, (5.66±0.24 mmol/L) , (336.5±1.4 mmol/L) , (90.8±1.3 mmol/L) respectively when compared with control group (34.27±0.9mmol/L) ,(516±1.8 mmol/L), (866±1.9 mmol/L) respectively for different age groups, and there was significant increase for males compared with females.There was a significant increase (P?0.01) in K+ level (5.896±0.05mmol/L) compared with control group (4.253±0.12mmol/L) and there was no significant correlation for males compared with females.There was a significant decrease (P?0.01) in Na+, Ca+2 level, (2.317±0.044 mmol/L), (144.35±1.6mmol/L) respectively compared with control group (1.89±0.046 mmol/L) , (121.00±1.1mmol/L) respectively and there was no significant correlation for different age groups or males and females, while there was a a significant correlation for male (1.979±1.1mmol/L) compared with female (1.768±0.073mmol/L).Result showed a significant decrease in HDL_c in the serum of patients before dialysis (1.263±0.027 mmol/L) compared with control (0.701±0.014 mmol/L) and there was a significant increase in HDL - c for female group compared with male group.There was significant increase in LDL_c in the serum of patients before dialysis (2.946±0.019mmol/L) compared with control (5.1±0.68mmol/L) and there was a significant increase in LDL - c for female (6.30±1.3 mmol/L) compared with male group(5.076±0.023mmol/L).

تحضير وتشخيص بعض مشتقات السكارين العضوية ومعقدات السكارين ومشتقاته الفوسفينية مع بعض الفلزات == Synthesis And Characterization Some of Organic Saccharin Derivatives And Metal Complexes of Saccharin And Its Phosphine Derrivative

Author name: عفراء صابر شهاب الزوبعي

Supervisor name: احمد عبد الحسن احمد الكاظمي | صبحي عطية محمود الجبوري

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: Tikrit University - Faculty Of Education - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: تضمن البحث تحضير عدد من الادوية المصاحبة المشتقة من مضادات التهاب غير ستيرويدية تم الحصول عليها من معمل ادوية سامراء هي الايبوبروفين، الاندوميثاسين، النابروكسين، الاسبرين، الكابتوبريل والايزونوزايد. عملية تحوير ال | In this study, a number of prodrugs have been synthesized starting from Non - steroidal anti inflammatory drugs such as Ibuprofen, Indomethacin, Naproxen, Aspirin, Captopril and Isoniazid. The modification process started from the conversion of carboxyl group which is existing in these drugs (except in Isoniazid) into esters, chlorides and acid hydrazide.The drugs have been linked to each other and to itself via amide linkage through the reaction of their acid chlorides and acid hydrazides to afford 1,2 - diacyl hydrazine derivatives(M17 - M27). Some acid hydrazides have been treated with isophthaloyl chloride to Benzene - 1,3 - dicarbo hydrazide - 1,3 - Bis substituent(M28 - M30). The same hydrazides have been treated with Benzen - 1,3,5 - tri carbonyl tri chloride to afford Benzen - 1,3,5 - tricarbhydrazide - 1,3 - Tris substituent (M31 - M33). Compounds M28 and M29 have been treated with POCl3 to afford Bis - substituent - 5 - phenyl - 1,3,4 - Oxadizole(M34 - M35). Another modification onto drugs has been done through the linking of these drugs with quinazoline nucleus through amide linkage to afford N - (4 - oxo - 2 - phenylquinazolin - 3(4H) - yl)amide - substit derivatives (M38 - M42). Another modification has been carried out through the reaction of hydrazides with Aromatic aldehydes to afford the mono hydrazide - hydrazones derivatives or Schiff's bases (M43 - M65) and di hydrazide - hydrazones derivatives in which two moles from hydrazide have been treated with one mole of dialdehyde(M66 - M73). In addition, new hydrazones have been synthesized through the reaction of hydrazides with Isatin nucleus which is well known as biological active center to afford the compounds (M74 - M77) with good biological activity. Benzodiazepines have been obtained through the reaction of Isoniazid hydrazones with glycene phthalimide and p - aminobenzoic acid(M82 - M92). Indomethacin hydrazones have been treated with acetic anhydride to afford 1 - [2 - (substituent) - 5 - (5 - methoxy - 2 - methyl - 1H - indol - 3 - ylmethyl) - [1,3,4]oxadiazol - 3 - yl] - ethanone derivatives (93 - M97). The Derivatives of 5 - substit - 2 - Mercapto - 1,3,4 - Oxadiazole(M98 - M103) have been obtained through the reaction of the drug hydrazides with CS2 in the presence of KOH. The oxadizoles have been treated with hydrazine hydrate to afford 4 - amino - 5 - sub - 4H - 1,2,4 - triazole - 3 - thiol derivatives for the Non - steroidal anti - inflammatory drugs(M104 - M107). In addition, 5 - sub - 1,3,4 - Oxadiazole - 2 - amine derivatives have been obtained through the reaction of drug hydrazides with BrCN(M108 - M111). The compound 5 - {1 - [4 - (2 - methylpropyl)phenyl]ethyl} - N3 - phenyl - 4H - 1,2,4 - triazole - 3,4 - diamine (M113) has been synthesized through the reaction of the compound 2 - {2 - [4 - (2 - methylpropyl)phenyl]propanoyl} - N - phenylhydrazinecarbothioamide (M112) with hydrazine hydrate. The ester compound 2 - hydroxyphenyl 2 - [4 - (2 - methylpropyl)phenyl]propanoate (M114) have been obtained through the reaction of Ibuprofen chloride with salicylic acid. The two compounds, 2 - (4 - Isobutyl - phenyl) - propionic acid [1 - (4 - methyl - piperazin - 1 - ylmethyl) - 2 - oxo - 1,2 - dihydro - indol - 3 - ylidene] - hydrazide (M115) and 2 - (4 - Isobutyl - phenyl) - propionic acid [5 - fluoro - 1 - (4 - methyl - piperazin - 1 - ylmethyl) - 2 - oxo - 1,2 - dihydro - indol - 3 - ylidene] - hydrazide (M116) have been obtained through the reaction of M74, M77 with excess of formaldehyde and equimolar of N - methyl piperazine.The synthesized compounds have been identified using Infra - red spectroscopy FTIR, Nuclear Magnetic resonance (1H,13C), Mass spectroscopy and X - Ray. In addition , the changes in physical properties such as melting points, boiling points and color have been considered. Finally, the biological activity of some synthesized compounds has been evaluated and some of them have shown good biological activity especially those containing Isatin nucleus (M74 - M77) and (M115 - M116).

تحضير وتشخيص بعض المشتقات البوليمرية الجديدة للبولي فاينايل الكحول == Synthesis And Identification of Some New Polymeric Derivatives of Poly(Vinyl Alcohol)

Author name: باسل محمد احمد حيود الجميلي

Supervisor name: احمد عبد الحسن احمد الكاظمي

General topic: Chemistry

Specific topic: Chemistry

Degree: Master

University: Tikrit University - College Of Education For Girls - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: تضمنت هذة الدراسة تحضير مركبات مختلفة لل 5,4 - ثنائي فنيل ايميدازول من خلال خطوات كثيرة : شملت الخطوه الاولى من البحث تحضير مركب الازو ايميدازول (H) وذلك عن طريق تفاعل الازدواج لل 5,4 - ثنائي فنيل ايميدازول مع املاح الديازونيوم 4 - امينو اسيتوفينون.اما ا | This study deals with the synthesis of new different compounds of 4,5 - di phenyl imidazole via many steps : The first part of this study includes synthesis of azo compounds of 4,5 - di phenyl imidazole by coupling reaction of 4,5 - di phenyl imidazole with Diazonium salts then of 4 - aminoacetophenone. The second part includes synthesis of new azo - chalcone derivatives (H1 - H4)by react on(H) coumpound with different derivatives of benzaldehyde.The third part includes the synthesis of oxazine compounds (H5 - H7) by reaction of (H1,H2,H3)respectively compounds with urea.The fourth part includes synthesis of Schiff base(H8 - H13) by the reaction of the compound(H) with different derivatives of aniline.The fifth part of includes synthesis of oxazepine derivatives(H14 - H21) from reaction of Schiff bases (H8 - H13)with phthalic anhydride and (H9,H10)with maleic anhydride,and synthesis of titrazoles derivatives (H22)from reaction of Schiff base(H12) with Sodium azid (NaN3).The final part of this research includes the biological activity study of some prepared compounds and showes that there is inhibitory activity against fungul.The chemical reaction are checked by using (T.L.C) Technique, all the prepared compounds were characterized by using FT - IR and (¹H - NMR) and (C.H.N) for some of these compounds , and these identification studies approved the correctness of structures for the prepared derivatives.The following schemes explains the stages of reactions for the prepared compounds

دراسة مستويات الفا ـ ل ـ فيوكوز وبعض الدوال الكيموحيوية في مصول دم النساء اللواتي عانين من الاجهاض المفرد للثلث الثاني من الحمل == Study of The Level ? - L - Fucose And Some Biochemical Parameters In Seram of Single Abortion At The Second Trimester of Pregnancy

Author name: فؤاد احمد عمر

Supervisor name: صباح حسين خورشيد

General topic: Chemistry

Specific topic: Chemistry

Degree: Master

University: Tikrit University

Language: Arabic

University location: Salahaddin

First pages:

Abstract: تضمن البحث اجـراء بعض التحويرات الكيميائيـة الجديدة للبولي(فاينايل الكحول) وتضمنت التفاعلات تحوير مجموعة الهيدروكسيل الى مجموعة الزانثيت للحصول علـى ملح زانثيت الصوديوم البوليمري , وقد استخدم هذا الملح للتفاعل مع كل من : - 1 - اورثو كلورو بنزيل كلورايد و| This research includes some new chemical modifications which have been done on Poly(vinyl alcohol) through the hydroxyl group which has been converted to xanthate group to obtain the polymeric sodium xanthate salt and the later has been used for the reaction with the followings : 1 - O - chlorobenzyl chloride and 1,3 - Dibromopropane to get xanthate esters also the xanthate salt was reacted with ammonium chloride to form the polymeric ammonium xanthate salt.2 - The reaction with iodine to form the polymeric crosslinked Dixanthate.3 - The reaction with diazonium salts prepared from aniline , P - nitro aniline , benzidine , 4,4 - methylene dianiline to form the diazoxanthate polymers. 4 - The reaction with some transition metal ions such as (Ni2+, Mn2+, Co2+) to form some polymeric complexes.The other part of the work includes the oxidation of Poly (vinyl alcohol) to get the oxidized form Poly(oxomethylene) which was reacted with hydrazines to prepare polymeric hydrazones and azine and also gallic acid has been used to esterify the poly(vinyl alcohol) to get poly(vinyl gallate) and phosphorus pentachloride to prepare polymeric trialkyl phosphate.Finally a thermal elimination experiment has been done on one of the polymeric xanthate ester to yield polyene.The polymeric products have been identified spectroscopically using the IR and UV technique , one of the products has been identified by NMR technique and some of the polymeric products have been analyzed for (C.H.N.S.) and also the magnetic susceptibility of some complexes have been measured.

تحضير عدد من المركبات الحلقية غير المتجانسة المشتقة من 2 - امينو - 6 - بروموبنزوثايازول وتقييم تاثيرها البيولوجي == Synthesis of Some Heterocyclic Compounds Derived From 2 - Amino - 6 - Bromobenzothiazole And Evaluation Their Biological Activity

Author name: خالد عبد العزيز عطية البدراني

Supervisor name: خالد مطني محمد الجنابي | احمد خضر احمد الخياط

General topic: Chemistry

Specific topic: Chemistry

Degree: Master

University: Tikrit University - Faculty Of Education - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: اجريت هذه الدراسة لتحديد الدوال المدروسة مع عينات عمرية لنساء مصابات بالاجهاض للثلث االثاني من الحمل ومستويات تركيزالفيوكوز الكلي Total fucose (TF), والفيوكوز المرتبط بالبروتين protein bound fucose (PBF), والسكريات السداسية المرتبطة بالبروتين (PBH) protei | The study was done to determine the relationship between the causes of abortion in women during the second trimester of pregnancy and total fucose (TF) level , protein bound fucose (PBF) , protein bound hexose (PBHex) and other biochemical parameter , which include : thyroid gland hormones ( T3, T4 ,TSH ) and testosterone , progesterone and Prolactin as well as the estimation of the levels of cholesterol , triglyceride , high density lipoprotein( HDL) , low density lipoprotein ( LDL) , and very low density lipoprotein( VLDL) Samples of ( 53) patientshave been collected from Azadi hospital and General Kirkuk hospital who have suffered from abortion where the agesranged between ( 16 - 45) years divided into three age groups first age group( 15 - 24) years & second age group( 25 - 34) years & third age group( 35 - 44) years. also the studyincluded (40) healthy persons at same age groups regarded as control groups1. Significant increase in the levels of (TF & PBF ) and Significantdecrease in the levels of (PBHex in aborted women compared with non - pregnant women2. Significant increase in thyroid hormone (T3) for the first & third age group, and there is no significant difference for the second age group in aborted women compared with non - pregnant women. Significant increase in thyroid hormone (T4) for the first & third age group, and Significant decrease for the second age group in aborted womencompared with non - pregnant women. Significant decrease for the first & third age group and Significant increase for the second age group in thyroid hormone (TSH) in aborted women compared withnon - pregnant women.3. Significant increase in Testosterone hormone level For all age Groups in aborted women compared with non - pregnant women And Significant decrease in progesterone hormone level For all age Groups in aborted women compared with non - pregnant women. 4. Significant increase in Prolactin level in aborted women compared with non - pregnant women.5. Significant decrease in( cholesterol, triglyceride, LDL and VLDL) level in aborted women compared with non - pregnant women. 6. Significant increase in the levels of ( HDL ) for the first age group, and there is no significant difference for the second& third age group in aborted women compared with non - pregnant women.

تحضير وتشخيص عدد من معقدات البلاديوم (??) والبلاتين (II) مع مزيج من ليكاندات الثايويوريا او الحلقات غير المتجانسة الحاوية على الامين مع السكارين او الثايوسكارين == Synthesis And Characterization of Some Palladium (??) And Platinum(II) Mixed Ligand Complexes of Thiourea Or Heterocyclic Amine And Saccharin Or Thiosaccharine

Author name: نور عبد المجيد ضياف الدوري

Supervisor name: صبحي عطية محمود الجبوري | مظهر يونس محمد المهيدي

General topic: Chemistry

Specific topic: Organic Chemistry

Degree: Doctorate

University: Tikrit University - Faculty Of Education - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: تتناول هذه الاطروحة تحضير المركبات الحلقية غير المتجانسة ذات الحلقة الخماسية مثل معوضات الثايادايازول و3,2,1 - ترايازولين والثايازولدين - 4 - اون والحلقة الرباعية مثل الازتدين - 2 - اون والحلقة الثلاثية الاوكسازردين, فضلا عن تحضير الحلقة السداسية البرمدين | The thesis deals with hetero cyclic compounds with five member rings like thiadiazole substituted 1,2,3 - triazoline and thiazoldine - 4 - one, four member ring like azetidine - 2 - one and three member rings oxazirdine. Synthesis including six member ring compounds like pyrimidin - 2,4,6 - trione in addition to synthesis seven member ring compound like oxazepine are synthesized. In the present work 4 - bromo aniline is used as precursor for the synthesis of the required compound; the 2 - aminobenzothiazole - 6 - bromo (K1) is synthesized from the reaction of 4 - bromo aniline with potassium thiocyanate in presence of bromine, the later (K1) was reacted with ethyl chloroformate to give ethylcarbamate (K2),which is used for the synthesis of urea derivatives (K3 - 8).through (K2) reaction with substituted aniline. Pyrmidin - 2,4,6 - trione (K9 - 14) is synthesized from the reaction of malonic acid with urea derivatives in acetyl chloride.Schiff bases (K15 - 20) are prepared through the condensation of 2 - aminobenzothiazole with substituted benzyldehid. Seven member ring are synthesized by cyclaziation of Schiff bases (K15 - 20) by using malic anhydride in absolute ethanol to give 2 - aryl - 3 - N - 6 - bromobenzothiazole - 5 - 7 - dione oxazepene (K21 - 26). four member ring is prepared from the reaction of Schiff bases(K15 - 20) with chloro acetyl chloride in 1,4 - Dioxane in the presence of tri ethyl amine to give azetidine - 2 - one(K27 - 32). Thiazoldine - 4 - one(K33 - 38) is synthesized from the reaction of Schiff bases(K15 - 20) with thioglycolic acid in the presence of Zinc chloride. The Oxazirdine(K74 - 79) is also prepared from the reaction of Schiff bases(K15 - 20) with 3 - chloro per benzoic acid in pyridine. 2 - (2 - chloroacetamide) - 6 - bromobenzothiazole(K39) is prepared from the reaction of 2 - aminobenzothiazole - 6 - bromo (K1) with chloro acetyl chloride. The compound (K39) is used in the preparation of substituted aryl amino acetyl - 2 - amino - 6 - bromobenzothiazole (K40 - 46) through its reaction with substituted amine. The thiazoldine - 4 - one - 2 - imine (K47) is also synthesized from the reaction of compound (K39) with potassium thiocyanate. The thiazoldine - 4 - one - 2 - imine (K47) is reacted with substituted benzeldehyd to give 2 - (5 - (aryldin) - 2 - imino - 4 - oxo - thiazoldin - 3 - yl) 6 - bromobenzothiazole (K48 - 53).The 2 - (6 - bromobenzothiazole - 2 - ylimino) thiozoldine - 4 - one(K95) is prepared from the reaction of 2 - acetylamino - 6 - bromobenzothiazole(K39) with ammonium isothiocyanate in ethanol 96%. The thiazoldine - 4 - one(K95) is used in the preparation of 2 - (6 - bromobenzothiazole - 2 - ylimino) - 5 - (sub.Methyl) thiozoldine - 4 - one(K96 - 100) through its reaction with various amine and formaldehyde.The aminobenzothiazole (K1) is also used for the preparation of thiosemicarbazide (K54) by its reaction with carbon disulphide. The substituted 1,3,4 - thiadiazole (K55 - 60) is synthesized from the reaction of thiosemicarbazide (K54) with various of carboxylic acids in the presence of phosphorous oxychloride. The aminobenzothiazole (K1) is used in the preparation of aryl ( benzothiazole - 2 - ayl ) dithiocarbamate (K61 - 65) through its reaction with carbon disulphide and arylhalid or alkylhalid in ethanol.The 2 - azido - 6 - bromobenzothiazole (K66) is prepared from the reaction of sodium azide with diazonuim salt ( prepared from the reaction of benzothiazole (K1) with sodium nitrate , hydrochloric acid ). 1,2,3 - triazoline (K67 - 71) are synthesized through the reaction of 2 - azidobenzothiazole (K66) with various olefin in ethanol. The treatment of aminobenzothiazole (K1) with phenyl isothiocyanate gives (6 - bromobenzothiazole - 2 - yl) - 3 - phenylthiourea (K72) which is converted to (6 - bromobenzothiazole - 2 - yl) - 3 - phenyl - 2 - thioxydihydropermidine - 4 - 6 - one (K73) through its reaction with malonic acid in dry. Benzene. The 2 - hydrazinobenzothiazole (K80) is prepared from the reaction of 2 - aminobenzothiazole (K1) with a mixture from hydrazine hydrate and hydrochloric acid in ethylene glycol. Pyrazoline compounds (87 - 92) are synthesized from the reaction of chalcons (K81 - 86) ( which are prepared from the condensation of substituted benzaldehyde with acetophenone in a base medium ) with hydrazino (K80). The hydrazino (K80) is used in the preparation of 2 - amino( - 6 - bromobenzothiazole)isoandole - 1,3 - diaone (K93) and 1 - (2 - amino - 6 - bromobenzothiazole)pyrroline - 2,5 - di - one (K94) through its reaction with phathalic anhydride and malic anhydride in ethanol. For furthur work, the preparation of Schiff bases (K101 - 110) carried out. from the condensation of substituted benzaldehyde with hydrazino (K80) in the presence of glacial acetic acid in ethanol. The 3 - ( - 6 - bromobenzothiazole - 2 - ylamino) - 2 - (sub.aryl) - 5,7 - di - one oxazipene (K111 - 120) are synthesized by cyclazition of Schiff bases (K101 - 110) by using malic anhydride in methanol. Schiff bases (K101 - 110) are also used in preparation of 1 - ( - 6 - bromobenzothiazole - 2 - ylamino) - 4 - (sub.aryl) - 3 - chloro - 2 - oxo - zetidine - 2 - one (K121 - 130) through its rection with chloro acetyl chloride in presence of tri ethyl amine in 1,4 - Dioxan. The 3 - (6 - bromobenzothioazol - 2 - ylamino) - 2 - (substituted aryl)thiozoldin - 4 - one (K130 - 140) is prepared from the reaction of thioglycolic acid with Schiff bases (K101 - 110) in presence of zinc chloride in dry. Benzene. In order to show the antibacterial activity of prepared compounds (k11,k23,k41,k56,k61,k62,k89,k97,k112,k118,k126,k137,k139) are evaluated against four types of common bacteria (Bacillus subtillis, Staphylococcus aureus, Eschershia coli, Klebsiella peneuomina). The result of biological study are compared with standered antibiotic (Ciprofloxacine & Gentamycin). The structure of the synthesized compound are confirmed by I.R, 1H - NMR & 13C - NMR spectra and Some chemical physical data.

تحضير وتشخيص معقدات بعض العناصر الانتقالية مع ليكاندات نتروجينية ودراسة فعاليتها الحيوية == Preparation And Identification Complexes of Some Transition Metales With Nitrogeneus Ligands And Study Its Biological Activity

Author name: علي ابراهيم علي بكر الجبوري

Supervisor name: نهلة عبد الحميد عبد الجبار

General topic: Chemistry

Specific topic: Chemistry

Degree: Master

University: Tikrit University - College Of Science - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages:

Abstract: تضمن البحث تحضير كاشفين جديدين هما الكاشف 3 - ((4,5 - diphenyl imidazole) diazenyl) benzene sulfonic acid ويرمز له (DPIDBSA) والكاشـــف2 - ((3 - methoxy phenyl) diazenyl) - 4,5 - diphenyl imidazole ويرمز له (MBDPI) وذلــــك من مفاعلة ملـح الديازونيـوم ل | This thesis included the preparation of the two new reagents 3 - ((4,5 - diphenyl imidazole) diazenyl) benzene sulfonic acid (DPIDBSA) and 2 - ((3 - methoxy phenyl) diazenyl) - 4,5 - diphenyl imidazole (MBDPI) by reacting adiazonium salt solution of (3 - aminobenzene sulfonic acid) and (3 - methoxyaniline) with (4,5 - diphenyl imidazole) in alkaline ethanoic Solution.The identity of these reagents have been characterized by spectral methods such as(UV - Vis) , FTIR , another physical properties (m.p.) and elemental analysis.The ionization constant of the reagent (DPIDBSA) was determine using spectroscopic method , the pKa was equal to 9.9.Six chelating complexes of the above reagents were synthesized with metal ions) Co2+, Ni2+, Cu2+). The two wavelength of maximum absorption for the two reagents were found (422nm) and (416nm) respectively in ethanol and for the complexes formed between these ions with these reagents were found at (476, 492, 504nm) and (455, 458, 496nm) for cobalt(II) , nickel(II) and copper(II) respectively in aqueous medium.It has been prepared after fixing the optimum condition of concentration and acidity function, through the study of UV - Vis spectrum for reacting of metal solution and two reagents solution. For wide range of pH (5 - 11) and concentration which obey to Beer - Lambert Law.The structures were determine according to the mole ratio method and continuous variation method which is obtained from the spectroscopic studies of the complex solutions. The ratios of (metal : reagent) are equal to (1 : 2) for all the complexes ions.The stability of complexes in the solutions was also studied at the optimum conditions.Diagnosis the solid prepared complexes by UV - Vis spectrum in ethanol solution showed high chromic shift from as compared with free reagents in visible region to all the complexes prepared.Micro elemental analysis for all the complexes were prepared and the percentage of Co(II) and Cu(II) were determined , using flame atomic absorption spectroscopy, it was noticed a great accord between theoretical and particle ratio.The infrared spectrum of chelating complexes also studied and it's compared with the two reagents spectrum. They give notice change with free two reagents spectrum. These showed new bands that were not found original in two reagents spectra but other bands have been changed in shape, in trinity and location. This may indicate that a coordination between the metal ions and the two reagents prepared.The Conductivity measurements for solutions at (1×10 - 3M) in ethanol solution have shown non - ionic character for all chelate complexes.From the above observations, it's suggested stereo shapes for complexes, that show the two reagents (DPIDBSA) and (MBDPI) behave as bidentit reagent, we can conclude that the proposed geometrical structure of all chelate complexes are octahedral.The study also included using spectrum method for determination stability constant of complexes in the thermal rang (25 - 45C?) for complexes with reagent (DPIDBSA) while the thermal rang was (10 - 30 C?) for complexes with reagent (MBDPI), and calculating ?G , ?H and ?S for complexes.The bacterial activity of the ligand and it's complexes were studied toward two type of bacteria : 1 - Pseudomonas. aurginosa 2 - StaphylloCoccus. aureusThe complex of Ni(II) with reagent (DPIDBSA) and the complexes of Co(II), Ni(II) and Cu(II) with reagent (MBDPI) and metal ions solution showed high bacterial activity on Pseudomonas. aurginosa while the solution of two reagents and all chelate complexes prepared also the aqueous solution of metal ions don't showed any activity toward the two type of bacteria (StaphylloCoccus. aureus) (G+ve).

دراسة بعض المتغيرات الكيموحيوية على مرضى ضغط الدم

Author name: منال عدنان ابراهيم

Supervisor name: نزار احمد ناجي

General topic: Chemistry

Specific topic: Chemistry

Degree: Doctorate

University: Tikrit University - Faculty Of Education - Chemistry Department

Language: Arabic

University location: Salahaddin

First pages: