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دراسة كيميائية حيوية لهرمون اللبتين وعلاقته بالمتغيرات البيوكيميائية للمرضى المصابين بنقص وزيادة نشاط الغدة الدرقية == Biochemical study of leptin hormone and its relationship to biochemical parameter in hypo and hyperthyroid patients

Author name: ماهر خليل ابراهيم
Supervisor name: عبد المنعم حمد السامرائي | خضير عباس خضير
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Doctorate
University: Tikrit University - Faculty Of Medicine
Language: English
University location: Salahaddin
First pages:

Biochemical Investigation In Osteoporotic Patients

Author name: سندس حوام الخزرجي
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
University location: Baghdad

العلاقة بين تغيرات الاندروجين وعدم الاستجابة للانسولين في النوع الثاني لداء السكري عند الذكور == THE RELEVANCE OF ANDROGEN CHANGES WITH INSULIN RESISTANCE IN TYPE ?? DIABETIC MALES

Author name: نعمان عبادي محمد
Supervisor name: ماجد كاظم حسين
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: University of Kufa - Faculty Of Medicine
Language: English
University location: Najaf
First pages:

تاثير هرمون اللبتين وعلاقته بالهرمونات الستيرويدية والدهون في الاشخاص المصابين بمرض السكري == EFFECT OF LEPTIN AND ITS ASSOCIATION WITH STEROID HORMONES AND LIPID PROFILE IN DIABETIC SUBGECTS

Author name: سرى زاحم حسين السامرائي
Supervisor name: عبد المنعم حمد مجيد السامرائي
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Doctorate
University: Tikrit University - Faculty Of Medicine
Language: English
University location: Salahaddin
First pages:

دراسة الدهون الاسفنجية النشطة بايولوجيا والانزيمات الاستقلابية في كل من تضخم البروستات الحميد وسرطان البروستات الخبيث == Bioactive Sphingolipids and metabolizing enzymes in patients with benign prostate hyperplasia and malignant prostate cancer

Author name: رغدة عبد المنعم رزوقي
Supervisor name: رائد جاسم محمد التميمي | اسامة سليمان قدوري الناصري
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: Bioactive Sphingolipids an important molecules of structural and signaling lipids. In this study was highlight on new biomarkers uses to investigate prostate cancer by using new method HPLC fluorescence detector to measure concentration and activity enzymes sphingosine - 1 - phosphate lyase enzyme (SPL) and Acid Ceramidase enzyme (AC) by used new material (BODIPY) aromatic structural is binding with enzymes and give fluorophore product sensitive by HPLC fluorescence detector in patients have BPH and PC in serum and tissue and comparing with healthy men as (control). Eliza method was used to measured sphingosine - 1 - phosphate and Ceramide in patients (BPH and PC) in serum and tissue with controls in serum. Sphingolipids metabolites pathological processes, are established regulators of myriad cellular and sphingolipids research is intricate due to the role of these molecules in vastly different biologics, interconnected metabolic pathways and structural properties. Ceramide and sphingosine - 1 - phosphate (S1P), SGPL and AC have been defined as reciprocal regulators of cellular fate, and not surprisingly have been targeted for their role in cancer and their therapeutic potential, sphingolipid metabolic enzymes and lipids are metabolically interconnected and highlight recent findings to support the reciprocal role of Ceramide and S1P in cellular processes and in cancer. Studies show increase levels markers in serum and tissue in BPH and PC with healthy men and different Km and V max in AC and SPL between healthy, BPH and PC patients also this reaction was noncompetitive inhibition with enzyme because V max was change and Km was not change in all cases these results were accepted with studies in America and Spain (Liu, Y.Y.; Patwardhan, G.A.;et al. 2011).IXAim of study1 - 1 - The main aim of this study is found a new sensitive and specific bio markers for diagnosis prostatic cancer And other goals of conducting this study are : 2 - To measure activity of Acid ceramidase and Sphingosine - 1 - Phospate Lyase in sera and prostate tissue of patients with benign prostatic hyperplasia and prostate cancer and compare these activities of enzymes with normal controls.3 - To determine the concentration of bioactive Sphingolipids Ceramide and Sphingosine - 1 - phosphate in tissues and sera of the patients and control.4 - To correlate the level of bioactive lipids with serum PSA concentration to detect their use as additional biomarker for diagnosis and follow up of patient with prostate cancer.Methods : A case - control study design was employed in this study. On a total of 30 patients with confirmed PC, 30 patients with BPH and age matched 30 healthy men. Prostate tissue samples were obtained for patients were serum and urine samples were collected for patients and controls. Enzyme linked immune assay (Elisa) was used to measure S1P and Ceramide concentration in serum and tissue, while HPLC fluorescence detector was used to estimate activities of SPL and AC and measured Km and V max. Urine and serum samples were undergone biochemistry analysis. HbA1c was used to measure cumulative sugar for three groups. Protein in tissue was measure by brad ford method to PC and BPH patients.Results : The results showed that increase levels of Sphingosine 1 phosphate lyase and Acid ceramidase in serum and tissue in BPH and Malignant cancer in men these levels were different result in patient wereXtaken drugs or not and patients were taken chemotherapy or not and activity, Km and Vmax of enzyme SPL and AC were different in BPH and PC that men is inhibition enzymes was noncompetitive it had same Km but different data of control, BPH and PC men in tissue and serum.The concentration of S1P and Ceramide were different levels with control, and high levels in patients without any drugs or chemotherapy while levels of these markers still low with patients were taken drugs or chemotherapy and level of protein in tissue were raised. Results of biochemistry analysis still normal because we take patients without any D.M., renal failure, and hypertension.

دراسة كيميائية حياتية لارتباط المستضد بضاده الحيوي في مرضى داء CA19 - الكاربوهيدراتي 9 السكري من النوع الثاني باستخدام مقايسة الممتز المناعي المرتبط بالانزيم مع بعض التحويرات == Biochemical Studies of the Binding of CA 19 - 9 to its Antibody in Patients with type 2 Diabetes Mellitus using Enzyme - Linked Immunosorbent Assay with some Modifications

Author name: رسل رياض عباس
Supervisor name: حسن حسين طه السعيد | محمود شاكر خضير
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: University of Baghdad - Faculty Of Medicine
Language: English
University location: Baghdad
First pages:
Abstract: Carbohydrate Antigen CA19 - 9 has been widely utilized for diagnosis of different kinds of cancer such as pancreatic cancer, cancer of upper gastrointestinal tract. It may also be used as an indicator of pancreatic tissue damage that may be caused by diabetes.The method of enzyme linked immunosorbent assay (ELISA) for measurement CA19 - 9 in sera of patients with type 2 diabetes mellitus was developed using external CA19 - 9 antibody (competitive sandwich ELISA technique) and found to be suitable for the determination of a dissociation constant (Kd) of the binding of CA19 - 9 to its antibody in type 2 diabetic patients using scatchard plot. Objectives : - This study was performed to assess CA19 - 9 levels in sera of patients with type 2 diabetes mellitus with non - cancerous tissue by enzyme - linked immunosorbent assays (ELISA) and define the normal range (cutoff value) for the same marker in this patients also investigated the possible relationships of CA19 - 9 with fasting plasma glucose and HbA1c.This study present a new method for determination the dissociation constant (Kd) of the binding of CA19 - 9 to its antibody in type 2 diabetic patients using scatchard plot through development of ELISA (competitive sandwich ELISA technique).Different factors affecting this binding were extensively studied such as divalent cations, different halides, and Polyethylene (PEG - 6000).

دراسة بايوكيميائية لثمار نبات الكزبرة وتقييم الفعالية المضادة لنمو البكتيرية للمستخلص المائي والكحولي == Biochemical Study Of The Fruit Of Coriandrum Sativum L. (Umbelliferae) And Evaluation Of Its Antibacterial Activity

Author name: جدوع محمد هجيج
Supervisor name: عبد المنعم حمد مجيد السامرائي | جاسم محمد مهاوش الجنابي
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Tikrit University - Faculty Of Medicine - Department of Biochemistry
Language: English
University location: Salahaddin
First pages:
Abstract: تضم المملكة النباتية العديد من اصناف النباتات والتي تحتوي على مواد كيمياوية مهمة وتعتبر كمصدر لجسم الانسان بجانب الغذاء يحتوي النبات عدد من المواد التي تعتبر مصدر جيد للدواء بعض هذه النباتات مهمة في علاج الانسان والاخرى ذو تاثير سلبي كالنباتات السامة . تهدف هذه الدراسة الى محاولة فصل وتشخيص المركبات العضوية وتقدير الفعالية البكترية للمستخلص الكحولي والمائي لثمار نبات الكزبرة على بعض العزلات الممرضة والتي تتمثل بالبكتريا التالية Staphylococcus aurus, Pseudomonas aeruginosa , Klebsilla pneumonia, Escherichia Coli استخلصت المركبات الطبيعية الموجودة في النبات بواسطة الماء المقطر والكحول الاثيلي 95% .اظهرت نتائج الكشف الكيماوي التمهيدي احتواء النبات (ثمار الكزبرة) على مركبات الكلوسيدات، العفصيات ، الصابونيات .استخدمت تقنية الاستشراب بالطبقة الرقيقة(TLC) لفصل مكونات النبات باستخدام صفائح السليكا جيل وعدد من المذيبات العضوية واظهرت النتائج ان افضل المذيبات للمستخلص الكحولي هو مزيج ( البنزين - خلات الاثيل (19 : 1) وللمستخلص المائي هو الميثانول .استخدمت تقنية (Preparative TLC ) محاولة لعزل المركبات للمستخلص الكحولي باستخدام صفائح السليكا جيل مزيج البنزين - خلات الاثيل (1 : 19) كمذيب.جرى استخدام عمود الكروموتوقيا باستخدام السليكا جيل ومزيج البنزين خلال الاثيل كمذيب وبعدة احجام.جمعت الاجزاء الثلاثة المتداخلة،واستخدمت تقنية الغاز - سائل - كروموقوكرفيا لفصل (عزل) مكونات الاجزاء الثلاثة وتم تشخيصها بواسطة طيف الكتلة بواسطة جهاز GcMs - Qp 1000 الرباعي الاقطاب في مختبرات،منظمة الطاقة العراقية.جرى تقدير التركيز المثبط الادنى للعزلات البكترية لكلا المستخلصين واظهرت النتائج تقارب القيم . | The plant kingdom include many different classes of plants which contains chemical substances important resource for human body. Besides food, plant contains many substances which are consider to be good resource of drugs. Some of these plants are important to cure human beings, others having negative effects, such as the poisonous plants. The goal of this study is to evaluate the bioactivity of aqueous and alcoholic extracts of coriandrum sativum (fruits) on some pathogenic bacteria, which include staphylococcus aureus, Pseudomonas aeruginosa, klebsiella pnearmania and Escherichia coli. The natural compounds were extracted from the plant by distilled water and ethyl alcohol. The preliminary chemical analysis revealed that the plant contained glycosides, tannins, saponins and volatile oils and some organic constituents were separated and isolated by using chromatography technique (TLC ) , GC - MS - Spectrometry) . Minimal inhibitory concentration (MIC) of aqueous and alcoholic extracts were evaluated on some pathogenic bacteria which were obtained from Microbiology department College of Medicine, Tikrit University.

دراسة مقارنة لعقاري الريباكلينايد والكلبنكلامايد على السيطرة السكرية والببتيد - ج ومقاومة الانسولين لدى مرضى داء السكري النوع الثاني == Comparative Study Of Repaglinide And Glibenclamide On The Glycemic Control, C - Peptide And Insulin Resistance In Type 2 Diabetic Patients

Author name: رغد خليل ابراهيم
Supervisor name: رعد يحيى الحمداني
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: University of Al Mosul - Faculty Of Medicine
Language: English
University location: Mosul
First pages:

دور فرط الليفين والعامل VIII باحداث مرض تصلب الشرايين == The Role Of Hyperfibrinogenemia And Factor Viii As A Risk Factor For Atherosclerosis

Author name: سامي اكريم زبار الجنابي
Supervisor name: جاسم محمد الجنابي | محمد شريف عبد الله
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Tikrit University - Faculty Of Medicine - Department of Biochemistry
Language: English
University location: Salahaddin
First pages:

السيماء الكيميائية المناعية لمرضى النقيي المتعدد

Author name: عبد الحسين علوان فرج
Supervisor name: ناصر محمد فهد الربيعي | عبد الوهاب عبد الرزاق الشيخلي
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Doctorate
Language: English
First pages:

تقييم خميرة الرايبونيكليز, حامض السياليك الكلى,وبعض الدلائل الكيماوية حياتية في مصل المرضى المصابين باضطرابات الغدة الدرقية == Evaluation Of Ribonuclease, Total Sialic Acid, Total Protein, Albumin And Camma Globulin In Pateints With Thyroid Disorders

Author name: منال كمال رشيد العاني
Supervisor name: محمد علي العيد | ابراهيم تحسين ابراهيم
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

تقييم وضعية بعض المعادن عند مرضى اختلالات الغدة الدرقية == Evaluation Of Some Minerals Status In Patients With Thyroid Disorders

Author name: محمد عبد الجليل زيارة الكعبي
Supervisor name: عدنان فاضل النجار
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

دراسة كيمياحياتيه لـ CA 125 , HCG ودلائل كيمياحياتيه اخرى في انواع مختلفة من سرطان المبيض == Biochemical Studies Of CA125, HCG And Other Biochemical Parameters In Patients With Different Types Of Ovarian Cancer

Author name: محمد داود عبد الحسين
Supervisor name: ناصر محمد فهد الربيعي | رياض محمد صالح
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Doctorate
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

دور هرمون النمو الشبيه بالانسولين - 1 والهرمون المصاحب - 3 في الاطفال قصار القامة المصابين بنقص هرمون النمو == Role Of Insulin Like Growth Factor (IGF - 1) And Its Binding Protein (IGFBP - 3) In GH Deficient Short Stature Children

Author name: زينب علي عبد الرحيم
Supervisor name: نهلة مجيد الصقال | عبد الكريم يحيى السامرائي
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

تقييم مستوى البروكولاجين 1 ن الببتيدي - والاستيوبونتين في النساء ما بعد سن الياس المصابات بنخر العظام ويعانين من كسر فقري == Evaluation Of Serum Procollagen ? N - Terminal Peptide And Osteopontin In Postmenopausal Women With Vertebral Osteoporotic Fractures

Author name: رنا علي حمدي
Supervisor name: ختام عبد الوهاب علي | احمد عبد الباري
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

تقييم المدخر المبيضى كمؤشر للخصوبه بواسطة الفحص بالامواج فوق الصوتيه وعلاقته بمرتسم الهرمونات الجنسيه == Evaluation Of Ovarian Reserve As An Index Of Fertility By Ultrasonic Examination And Its Relation To Sex Hormones Profile

Author name: ايمان عبد الرضا مجيد
Supervisor name: نهلة مجيد توفيق | سامية عباس عليوي
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

مستوى هورمون اللبتين وبعض السيتوكينات في مصل دم الحوامل اللاتي يعانين الاسقاط التلقائي المهدد والاسقاط الفائت == Maternal Serum Levels Of Leptin And Some Cytokines In Threatened And Missed Miscarriage

Author name: اماني صفاء صاحب
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

تقييم العناصر المعدنية في المصل والشعر عند النساء المصابات باورام الثدي == Evaluation Of Minerals In Serum And Hair Of Female Patients With Breast Tumors

Author name: امال رشيد فرحان
Supervisor name: عدنان فاضل النجار | نهلة مجيد الصقال
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

قياس مستوى اوكسيد النتريك والنايترات في المصل واللعاب وعلاقته بالسيطرة على سكر الدم والمتلازمة الايضيه في مرضى الذكورالمصابين بداء السكري من النوع الثاني == Determination Of Nitric Oxide And Nitrites In Serum And Saliva, In Relation To The Metabolic Syndrome, Glycemic Control In Male Patients With Type 2 Diabetes Mellitus Diabetes Mellitu

Author name: اسراء عبد الخضر جاسم
Supervisor name: خالد سلطان عبد القادر | مروان صالح محمد النمر
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Mustansiriyah University - Faculty Of Medicine - Department Of Biochemistry
Language: English
University location: Baghdad
First pages:

تقييم التاثير لمثبط مختزل هيدروكسي مثيل كلوتاريل كو - اي على صورة الدهون ووظائف الكلية لدى مرضى زرع الكلية المصابين بارتفاع الكولستيرول == Evaluation The Effect Of HMG - CoA Reductase Inhibitor On Lipid Profile And Renal Function In Hypercholesterolemic Renal Transplant Recipients

Author name: معتز صباح حميد
Supervisor name: حازم حسين عيدان
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Tikrit University - Faculty Of Medicine - Department of Biochemistry
Language: English
University location: Salahaddin
First pages:

الجراثيم الهوائية واللاهوائية المعزولة من قرحة القدم المتسببة عن السكري == Aerobic And Anaerobic Bacteria Isolated From Diabetic Foot Ulcers

Author name: نيبال سامي ميكائيل
Supervisor name: هيثم محمد خليل الحبيب
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: University of Al Mosul - Faculty Of Medicine
Language: English
University location: Mosul
First pages:

تقييم مجموعة فحوصات الشحوم ووظائف الكلية لمرضى داء السكري حسب نظم العلاج الم == Evaluation Of Serum Lipid Profile And Renal Function Tests In Patients With Diabetes Mellitus On Different Therapeutic Regimen

Author name: عبد الباري محمد جاسم الجميلي
Supervisor name: جنان فاضل الدهان | صامت الياس قاسم
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Tikrit University - Faculty Of Medicine - Department of Biochemistry
Language: English
University location: Salahaddin
First pages:

A Study Of Simvastatian As Antoxidant Drug On Spermatozoal Oxidative Stress In Male Infertile And Subfertile Patients

Author name: احمد صادق علي الحلي
Supervisor name: نجاح رايش هادي الموسوي | جاسم محمد الجنابي
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Doctorate
University: Tikrit University - Faculty Of Medicine - Department of Biochemistry
Language: English
University location: Salahaddin
First pages:

تقييم فعالية انزيم الفا ـ اميليز في مصل دم ولعاب الاشخاص الطبيعيين ومرضى داء السكري == Evaluation Of Alpha - Amylase Activity In Serum And Saliva In Diabetes Mellitus

Author name: سرى زاحم حسين السامرائي
Supervisor name: عبد المنعم حمد مجيد السامرائي | جنان فاضل الدهان
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Tikrit University - Faculty Of Medicine - Department of Biochemistry
Language: English
University location: Salahaddin
First pages:

تحديد الفضلات الغازية السامة وعلاقة ذلك بالمعايير الكيميائية الحياتية والدموية لدى الافراد العاملين في منطقة شركة نفط الشمال == Determination Of Toxic Gaseous Wasteproducts And The Relation Of That With Biochemical And Hematological Indices In Individuals Working In The North Oil Company Region

Author name: سالم جاسم خلف
General topic: Medicine
Specific topic: Medical Biochemistry
Degree: Master
University: Tikrit University - Faculty Of Medicine - Department of Biochemistry
Language: English
University location: Salahaddin
First pages:
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