Author name:
سمى يعقوب يوسف
Supervisor name:
رائد معلك الصالح | مهند عبد الرضا الشريفي
Abstract:
The present study has been designed to evaluate and compare changes in patients pre, post and long periods for cholecystectomy on BMI, liver function (Aspartate Amino Transferase (AST), Alanine Amino Transferase (ALT), Alkaline Phosphatase (ALP), Total Bilirubin (TSB), Total Protein (TP), lipid profile (Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Very Low Density Lipoprotein (VLDL)), oxidative stress (Malondialdehyde (MDA), Nitric Oxide (NO)) and antioxidant state (Albumin (Alb), Ceruloplasmin (CP)). | The study includes (192) subjects : (64) normal subjects (control) and (128) patient’s cholecystectomy, their age range (20-69) years, the patients were divided in to three groups : (64) patients pre and 24 hr post operation cholecystectomy, (64) patients after long periods for cholecystectomy, as well as the patients were divided by age into two groups : a premenopausal group and a postmenopausal group. | The results show that there were a significant decreased in the concentration of serum (AST, ALT, TSB, DB, InB, HDL and Alb) in group pre in comparison with each of post (short and long terms) and control groups (p≤0.05). It was found no significant differences in the concentration of serum (AST, ALT, TSB, DB, InB, HDL and Alb) between each of post (short and long terms) groups (p≤0.05). Also it was found significant differences in the concentration of serum (AST, ALT, TSB, DB, InB, HDL and Alb) between each of post (short and long terms) and control groups (p≤0.05). | -----------------------------INDEX--------------------------------- | XII | While the results showed a significant increase in the concentration of serum (ALP, TP, TC, LDL, NO, MDA and Cp) in all patient groups in comparison with control groups (p≤0.05). It was found no significant differences in the concentration of serum (ALP, TP, TC, LDL, NO, MDA and Cp) between each of post (short and long terms) groups (p≤0.05). Also it was found significant differences in the concentration of serum (ALP, TP, TC, LDL, NO, MDA and Cp) between each of post (short and long terms) and control groups (p≤0.05). | Also the results showed a significant increase in the concentration of serum TG and VLDL in all patient groups in comparison with control groups (p≤0.05). It was found no significant differences in the concentration of serum TG and VLDL between each of post (short and long terms) groups in the group A (p≤0.05). But it was found a significant difference in the concentration of serum TG and VLDL between each of post (short and long terms) in the group B (p≤0.05). Also it was found a significant difference in the concentration of serum TG and VLDL between each of post (short and long terms) groups and control groups (p≤0.05). | The correlation between nitric oxide and each of (ALP, TP, TC, TG, LDL, VLDL, MDA and Cp) in these patient groups were positive. Whereas the correlation between nitric oxide and each of (AST, ALT, TSB, BD, InB, HDL and Alb) in these patient groups were negative. | The above reviewed results lead to conclusion that cholecystectomy causes variant alternations in serum hepatic function and lipid profiles and causes variant effects in serum oxidative stress. Also, age has no effect on each of (ALT, TSB, DB, InB, ALP, TP, TG, VLDL, NO, MDA, Cp and Alb), while age has effect on each of (TC, LDL and HDL). Besides, there are no effect of the period after cholecystectomy on all studied parameters except TG and VLDL.
