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عزل وتشخيص الاصابات البكتيرية المسببة لالتهابات المجاري البولية لدى مرضى سرطان البروستات في محافظة كربلاء == Isolation and Identification of Bacterial Causative Agent of Urinary Tract Infections from Patients with Prostate Cancer in Kerbala

اسم المؤلف: احمد عبد الحميد عبد العزيز الصفار

اسم المشرف: حسن علي حسين السعدي

الموضوع العام: علوم الحياة

السنة: 2022

الموضوع الدقيق: التحليلات المرضية

الدرجة: ماجستير

الجامعة: جامعة كربلاء - كلية العلوم الطبية التطبيقية - قسم التحليلات المرضية

اللغة: الانكليزية

مكان الجامعة: كربلاء

الصفحات الاولى:

المستخلص: This study aimed to identify the most common bacterial isolation that were correlated with patients suffering from prostate cancer, study antibiotic susceptibility pattern. During the period extending between (November 2021 to April 2022) from the Imam Hussain Center for Oncological and Hematological Diseases Directorate, urine samples were obtained from so suspected patients suffering from prostate cancer, their age were ranged from 51 to 80 years. Collected 50 urine sample. The Vitek 2 system was the method that used for identification of bacterial species. The results showed that out of 50 urine samples, (58%) had non-significant bacteria growth, (42%) were found with significant bacterial growth.The result of bacterial isolates was (81%) of Escherichia coli, (14.3%) of Enterobacter cloacae and (4.7%) of Klebsiella pneumoniae. The most growth of E.coli isolates was within 8-10 Gleason score group (56%), this indicates that this category (Gs 8-10) is a risk factor and an encouragement for the growth of E. coli in prostate patients. The results of the present study showed that E. coli and Enterococcus are present in large number relatively in the urine of subjects with prostate cancer.Increased levels of these two types of bacteria in urine may indicate that a significant degree of inflammation occurs in those with prostate cancer.Current study showed that Gleason score (8-10) with 25 patients (50%); and documented increasing prostate specific antigen in age group (70-79) years. also, the results revealed there were 17 (34%) patients within the overweight group and severe Gleason scores (8-10) that may indicate that being overweight is a risk factor for the severity of prostate cancer. Vitek 2 compact system was used to check for antibiotic sensitivity among all of the identified isolates. The extracted data show that out of 46 antibiotics tested, E. cloacae isolates (A10: 33, A18 and A39: 11) were resistant to antibiotics and (A10: 5, A18 and A39: 21) sensitive to antibiotics with different percentage, K. pneumoniae was resistant to 3 antibiotics and sensitive to 22 antibiotics and E. coli isolates was resistant to 29 antibiotics, intermediate to 3 antibiotics and sensitive to 32 antibiotics with different percentage among isolates.

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