تحضير، تشخيص وتقييم بايولوجي لبعض الادوية المصاحبة المشتقة من بعض مضادات الالتهابات غير الستيرويدية == Synthesis , Characterization And Biological Evaluation of Some Prodrugs Derived From Non - Steroidal Anti - Inflammatory Drugs (NSAID's)
Author name:
مصطفى راجي عايد حمد
Supervisor name:
خالد مطني محمد الجنابي | اياد سعدي حميد الدليمي
Abstract:
اجري هذا البحث لايجاد العلاقة بين العجز الكلوي المزمن ومستويات بعض المتغيرات الكيموحيوية عن طريق قياس مستوى انزيم الرينيين والفيوكوز الكلي (TF), الفيوكوز المرتبط بالبروتين (PBF) , البروتين المرتبطة بالسكريات السداسية (PBHex) وعدد من المتغيرات الكيموحيوية | This study has been done to determine the relationship between chronic renal failure and the level of some biochemical parameters (Rennin enzyme, Total Fucose(TF), Protein bound Fucose(PBF), protein bound Hexose (PBHex), and some other biochemical parameters including glucose , Urea, createnine, Uric acid, High density lipoproteins Cholestrol(HDL - c.), low density lipoproteins Cholestrol (LDL - c.) and electrolytes (Na+, K+ and Ca+2). Case study included (80) patients with chronic renal failure,Who admitted to the Kirkuk General Hospital Department of Dialysis , there ages were (31 - 60 years) of both sexes , patients has been divided into subgroups according to age {(31 - 35),(36 - 40),(41 - 45),(46 - 50),(51 - 550),(56 - 60)}year and severity compared with (45) normal persons as control with same ages, the results was as follows : Results showed a significant increase (P?0.01) in the level of rennin enzyme (5.013±0.052 ng/mL.h) of patients before dialysis compared with control group (2.58±0.32 ng/mL.h) for different age groups, and there was a significant increase slightly for different age groups.There was a significant increase (P?0.01) in the level of TF and PBF (12.14±0.89 mg/dL),(7.450±0.18 mg/dL) respectively compared with control group (28.76±0.03 mg/dL), (2.26±0.27 mg/dL) respectively for different age groups, and there was no significant correlation between age groups or sex.There was significant decrease (P?0.01) in the level of protein bound hexose PBHex, (123.35±0.9 mg/dL) compared with control group (89.76±0.9 mg/dl) for different age groups, and there was no significant correlation between age groups or sex.There was a significant increase (P?0.01) in the level of glucose (5.072±0.13 mmol/L) compared with control group (7.03±0.46 mmol/L) for different age groups, and there was a significant increase for females (7.40±0.7 mmol/L) compared with males (6.84±0.4 mmol/L).There was a significant increase (P?0.01) in the level of urea, uric acid and createnine, (5.66±0.24 mmol/L) , (336.5±1.4 mmol/L) , (90.8±1.3 mmol/L) respectively when compared with control group (34.27±0.9mmol/L) ,(516±1.8 mmol/L), (866±1.9 mmol/L) respectively for different age groups, and there was significant increase for males compared with females.There was a significant increase (P?0.01) in K+ level (5.896±0.05mmol/L) compared with control group (4.253±0.12mmol/L) and there was no significant correlation for males compared with females.There was a significant decrease (P?0.01) in Na+, Ca+2 level, (2.317±0.044 mmol/L), (144.35±1.6mmol/L) respectively compared with control group (1.89±0.046 mmol/L) , (121.00±1.1mmol/L) respectively and there was no significant correlation for different age groups or males and females, while there was a a significant correlation for male (1.979±1.1mmol/L) compared with female (1.768±0.073mmol/L).Result showed a significant decrease in HDL_c in the serum of patients before dialysis (1.263±0.027 mmol/L) compared with control (0.701±0.014 mmol/L) and there was a significant increase in HDL - c for female group compared with male group.There was significant increase in LDL_c in the serum of patients before dialysis (2.946±0.019mmol/L) compared with control (5.1±0.68mmol/L) and there was a significant increase in LDL - c for female (6.30±1.3 mmol/L) compared with male group(5.076±0.023mmol/L).
