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تقييم مستوى الثرومبوسبوندين لدى مرضى السكري النوع الثاني Assessment of Thrombospondin Level In Diabetic Patients Type II

اسم المؤلف: وجدان راجح حمزة الكريطي

الجامعة: جامعة الكوفة - كلية العلوم - قسم علوم الحياة

اسم المشرف: ارشد نوري غني الدجيلي

الموضوع العام: علوم الحياة

الموضوع الدقيق: الحيوان

الدرجة: ماجستير

اللغة: الانكليزية

السنة: 2014

مكان الجامعة: النجف

المستخلص: The present study is intended to asses serum levels of Thrombospondin - 1, Fasting blood glucose, Glycated Hemoglobin A1c, Lipid profile and BMI in type 2 diabetic patients, also correlation between Thrombospondin - 1 with all criteria above in both males and females.The study was conducted on randomly selected 65 type 2 diabetic patients (34 males and 31 females) attending the diabetes mellitus center in Al - Sadder Teaching City in Al - Najaf province, Iraq and a group of 24 apparently healthy subjects (12 Males and 12 Females) were included as a control group. The Study was carried out from August 2013 to February 2014.The patients' age was ranging of 35 to 64 years old.The results indicated a significant increase (p<0.05) in serum FBG, Cholesterol, TG, VLDL - C, LDL - C, TSP - 1 levels and a significant decrease (p>0.05) in serum HDL - C level in diabetic patients in comparing with healthy groups. The results also revealed that significant increase (p<0.05) in serum HbA1c level and BMI in diabetic patients in comparing with healthy groups.The results also revealed no significant differences (p> 0.05) in serum Cholesterol, Triglyceride, VLDL - C, LDL - C, HDL - C and TSP - 1 levels between males and females in both patients and health groups, while the results of FBG and HbA1c levels increase significantly (p<0.05) in females than males in both patients and health groups.The results show that Cholesterol, Triglyceride, VLDL - C, LDL - C, TSP - 1, FBG and HbA1c levels increase significantly (p<0.05) in both males and females patients groups in comparing with males and females of healthy groups respectively, and a significant decrease (p<0.05) in serum HDL - C in both males and females patients groups in comparing with males and females of healthy groups respectively.The results indicated a significant increase (p<0.05) in serum TSP - 1 level in females than males patients at same BMI (over weight and obese) except normal weight there is no significant differences (p>0.05) and there is no significant differences (p>0.05) between males and female of control groups at same BMI.The results show that TSP - 1 increase significantly (p<0.05) with increasing age of patients in males and females patients and the ages (55 - 64y) are highly significant(p<0.05) than (45 - 54y) and (35 - 44y), But there is no significant differences (p>0.05) in males and females of healthy groups at different ages. while there is a significant increase (p<0.05) in serum TSP - 1 level at same ages in both males and females patients in comparing with males and females of healthy groups respectively. The results also indicated that TSP - 1 increasing significantly (p<0.05) with increasing duration of disease in males and females patients and the (11 - 15y) reveals a highly significantly (P<0.05) than (6 - 10y) and (1 - 5y). The results have been shown significant positive correlation (P<0.05) between TSP - 1 and FBG, TSP - 1 and HbA1c, TSP - 1 and BMI, TSP - 1 and cholesterol, TSP - 1 and TG, TSP - 1 and LDL - C, TSP - 1 and VLDL - C in (males and females), males, females DM patients. The results have been shown significant negative correlation (P<0.05) between TSP - 1 and HDL - C in (males and females), males, females DM patients. The present study concluded that Thrombospondin - 1 and HbA1c levels were markers for detection and diagnosis of diabetic patients type

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