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دراسة المضاعفات التنفسية من المرضى الذين يعانون من الاورام الخبيثة الدموية بعد العلاج الادوية السمة للخلايا في مستشفى بغداد التعليمي == Study of Respiratory Complications of Patients with Hematological Malignancies Following Cytotoxic Drugs Therapy in Baghdad Teaching Hospital
Author name:
مهند حسن جابر
Supervisor name:
عدنان الجبوري
General topic:
Medicine
Specific topic:
Psychiatry
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
First pages:
19T1403 - p.pdf
Abstract:
Hematological malignancies include lymphoblastic which divided into acute lymphoblastic leukemia is the commonest cancer in children andchronic lymphoblastic leukemia , myeloid leukemia also, acute and chronic , Hodgkin and non Hodgkin lymphoma and multiple myeloma all of these malignancies given cytotoxic drugs and most cytotoxic drugs cause pulmonary toxicity .Aim of study : To assess the respiratory complications following treatment with cytotoxic drugs in patients with hematological malignancies .Patients and method : A hospital based prospective study conducted between first of October 2015 to first of July 2016 in Baghdad teaching hospital hematology unit including 50 patients 25 male and 25 female .Patients information include their age ,sex, residence ,job address and smoking history name of hematological disease, type and duration of cytotoxic drug given.Inclusion criteria : 1 - All patients took chemotherapy mention name of drug , dose and duration of treatment.2 - All patients not have any respiratory signs or symptoms before taking chemotherapy but after took it will develop respiratory disease took the most common symptoms in respiratory disease which include cough ,shortness of breath, chest pain and hemoptysis.3 - All patient in our research have chest x - ray and CT scan findings All patients have oxygen saturation measurement by pulse oximeter .Exclusion criteria : - Exclude any patient have respiratory disease before taking cytotoxic drugs.Results : A total of 50 patients with diagnosis of respiratory disease after taking cytotoxic enrolled in study the mean age of patients was 39.7±18.2 years ( range 16 - 75 years) male to female ratio was 1 : 1 all these patients take cytotoxic drugs for treatment of their malignancies and develop respiratory signs and symptoms , we found that NHL was the most common malignancy in 17 (34%) patients and cytarabin was the most common cytotoxic drug use and cause respiratory complication, the most common respiratory symptom was shortness of breath in 44 patients , right lower zone most common site affected in 22 patients and patch was the commonest lesion in 26 patients, streptococcus viridance was the most significant microorganism in 11(22%) patients and we found only chest pain was significantly associated with deteriorated outcome (P <0.05).The Conclusion : We conclude from this study the following : - most of bacterial infection in hematological diseased patients causedby streptococcus viridance pneumonia were affect 11 patients (22.0%)from all 50 patients and induced by cytotoxic drugs and is the mostcommon cause for mortality and need careful monitoring and follow - up. - invasive fungal infection mostly caused by aspergillus fumigatus werefound in 4 patients and Candida albicans were also, found in 4 patientsand need careful monitoring . - also conclude from this study that pnemocystic jiroveci can affect hematological diseased patients which is found in one patients (2.00%) from 19 patients do cultures for them.
