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سرطان الثدي لدى النساء العراقيات في العقد الخامس من العمر == Iraqi Female Breast Cancer In Their Fifth Decade (Retrospective Study
Author name:
ضحى محمد كاسب
Supervisor name:
منور عبد الاله النقاش
General topic:
Medicine
Specific topic:
Therapeutic Radiology
Degree:
Higher Diploma
University:
University of Baghdad - Faculty Of Medicine
Language:
English
University location:
Baghdad
Key words:
- Iraqi breast cancer
- molecular classification
- Luminal A like
- DFS
First pages:
19T1570 - p.pdf
Abstract:
the United States, breast cancer remains the most frequent cancer in women and the second most frequent cause of cancer death.Breast cancer incidence generally increases with age. Age of the patients is an important factor both for the occurrence and management of the disease Objective : The aim of this study to assess Iraqi female breast cancer patients’ clinical profile in their fifth decade, Evaluate patients’ molecular profile and 5years DFS.Patients and methods This is aretrospective study was conducted in Baghdad oncology teaching hospital fromJanuary12012 toDecember122016, carried on979breast cancer female patients 285patients of them ranging between(40to49)years with their histopathology reports and immunohistochemichal (IHC) results including ER, PgR, HER2/neu The patients in this study underwent surgical intervention either by a biopsy or mastectomy with axillary clearance, and the formalin - fixed paraffin - embedded tissue blocks were sent to the hospital’s laboratory for H&E and IHC.ResultsThe mean age 45 years, the highest incidence of breast cancer among patients in 5th (40 - 49 years) and 6th (50 - 59 years) decades of life(29% and 28%)respectively , while the lowest incidence in 80 years and more female. Regarding the stage ;stage II and III were the most common stages at diagnosis (40.8% and 39.5%) respectively ,while CIS is the lowest stage(3.1%).XIILuminal A like were 124 patients (58.5%), Luminal B like were 30 patients (14.2%), Triple negative were 29 patients (13.7%) and HER2 overexpressed were 29 patients (13.7%). The highest frequency was seen among patients with Luminal A like followed by Luminal B - like . Denovo metastatic patients occupy only 6.7% from all studied group. DFS was 48 months with (95% CI : 41.4 - 54.5 months).ConclusionsHighest prevelance of breast cancer was seen in 5thand 6th decades. Stage II breast cancer is the most common stage at diagnosis. Luminal A was the most common molecular subtype of the breast cancer patients in the studied group.Her2overexpressed and triple negative were the lowest with the same percentage. Most patient s in our study were overweight or obese.Median DFS was 48 months.
